category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	49/1002	205/9376	2.23661944403875	HLA-E/JUN/HLA-A/SCIN/CCND1/HLA-G/RBPJ/PIK3R3/YWHAE/CHD4/NFKBIA/HLA-F/EGR2/MRPS18B/HLA-B/PIK3R2/IRF7/IRF9/CDKN2A/ACTN4/ATF6B/PRKACA/PMAIP1/CDKN2B/MAD1L1/GTF2H2/SCRIB/GTF2H1/H2BC5/HPN/NFKB2/CCNE1/KAT2A/STAT3/HRAS/DNAJA3/DDX3X/ATF4/SKP2/CREB3/HDAC8/GRB2/PIK3R1/EGR3/H2BC15/GTF2H3/RB1/H2BC11/CDK4	6.19238108451622
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	51/1002	224/9376	2.13045337895637	HLA-E/JUN/HLA-A/EGR1/NRP1/CCND1/HLA-G/CANX/PIK3R3/NFATC2/TNF/IL2RA/SLC25A4/NFKBIA/GPS2/ITGB2/HLA-F/EGR2/HLA-B/PIK3R2/HLA-DRB1/CDKN2A/TNFRSF1A/B2M/FOS/TLN1/ATF6B/PRKACA/CDKN2B/CD4/MAD1L1/SLC2A1/NFKB2/ATM/CCNE1/KAT2A/TGFB2/HRAS/MSX2/ADCY6/CDKN2C/ATF4/CREB3/PIK3R1/FDPS/HLA-DRB3/ADCY7/HLA-DQB2/RB1/CDK4/MSX1	5.92340844845092
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	26/1002	88/9376	2.76465251315551	F13A1/C2/SERPINE2/C1QA/CFD/C4BPB/VSIG4/C1QC/C1QB/CFI/A2M/SERPINE1/CR1/C9/ITGB2/CFHR1/CD59/KLKB1/SERPING1/ITGAM/C3AR1/CFB/PROS1/C4BPA/SERPINF2/TFPI	5.7529745443238
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/1002	155/9376	2.17330500289743	COLEC12/MRC1/HLA-E/CTSL/CD14/HLA-A/TUBA1B/HLA-G/ITGB5/TUBB/CANX/TLR4/SCARB1/NCF4/ITGB2/FCGR2A/HLA-F/HLA-B/HLA-DRB1/CD209/LAMP1/ITGAM/TUBB2A/TAP1/STX7/TAP2/TFRC/RILP/ATP6V0A1/TLR6/RAB5C/HLA-DRB3/DYNC2H1/HLA-DQB2/ATP6AP1/ATP6V0E2	5.09496002916877
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	47/1002	227/9376	1.93741152057119	HLA-E/CCL3/CCL4/HLA-A/CCND1/HLA-G/GNG12/PIK3R3/CCL2/NFATC2/TNF/GNG10/NFKBIA/ITPR2/TAPBP/HLA-F/CCR1/HLA-B/PIK3R2/CDKN2A/TNFRSF1A/GNAS/B2M/CALML4/PTK2/ATF6B/PRKACA/CALM3/PRKCA/TAP1/TAP2/EGFR/CGAS/ARHGEF12/STAT3/HRAS/ADCY6/ATF4/CREB3/GRB2/PIK3R1/ROCK2/PLCB3/GNA11/ADCY7/RB1/CDK4	4.94549107093989
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	50/1002	250/9376	1.87145708582834	CTSB/CTSL/CTSC/LGMN/CLTC/CTSZ/NEU1/CLN8/AP2A2/CTSD/FUCA1/CLN6/PLA2G15/MAN2B1/AP1B1/HEXA/MCOLN1/SCARB2/TPP1/TLR7/CLTA/LAMP1/OSBPL6/ACP2/AP2M1/VPS13C/NCOA7/TPCN1/VPS11/HEXB/GAA/HYAL2/SLC36A1/CTSK/NAGLU/ATP6V0A1/ACP5/AP3D1/CLN3/VPS16/AP1S1/PSAP/CTSO/CTSF/GNPTAB/ATP6AP1/CTNS/ATP6V0E2/PLEKHM1/BORCS5	4.83090835002788
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	40/1002	184/9376	2.03419248459603	PLCG2/NRP1/EPHB3/ENAH/PIK3R3/LRRC4/NFATC2/NCK2/RGMA/WNT5B/SEMA3D/ABLIM3/PIK3R2/EFNA2/PLXNA1/PLXNB2/SEMA4A/PTK2/PRKCA/SEMA4B/SEMA7A/EFNB1/FZD3/SRGAP3/ARHGEF12/PLXNA3/SRGAP1/HRAS/SEMA3B/EPHA2/SMO/UNC5C/PIK3R1/ROCK2/LIMK1/PLXNA2/SEMA4C/EFNA4/PAK6/EPHB6	4.9007020779601
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/1002	82/9376	2.62460444963731	HLA-E/CTSB/CTSL/LGMN/HLA-A/HLA-G/HSP90AA1/CANX/TNF/HSP90AB1/TAPBP/HLA-F/HLA-B/HLA-DRB1/B2M/CD4/TAP1/TAP2/IFI30/HSPA2/HLA-DRB3/HSPA8/HLA-DQB2	5.11100435722746
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/1002	142/9376	2.17458041663153	PLCG2/CSF1R/JUN/FOSB/SQSTM1/LILRB4/PIK3R3/LILRB5/NFATC2/TNF/NFKBIA/NCF4/FCGR2A/ITPR2/PIK3R2/LILRB3/IRF9/TNFRSF1A/FOS/JUNB/SIRPA/NFKB2/TEC1/LILRA6/TGFB2/CTSK/ATP2A2/ACP5/IFNGR2/GRB2/PIK3R1/BLNK/LILRA4	4.87848544378994
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	26/1002	103/9376	2.36203321512315	FN1/HSPB1/CD14/PIK3R3/TNF/COL1A2/TLR4/C9/ITGB2/COL4A1/PIK3R2/GNAS/ACTN4/PTK2/ITGAM/PRKACA/PRKCA/LAMA3/LAMB2/SERPINB6/CXCL1/TGFB2/RAB5C/PIK3R1/PLCB3/GNA11	4.80783109256764
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	31/1002	137/9376	2.11734195841893	CTSB/JUN/CTSL/CTSC/LMNA/TUBA1B/CTSZ/CTSD/PIK3R3/TNF/NFKBIA/ITPR2/PIK3R2/TNFRSF1A/SEPTIN4/FOS/NOL3/PARP1/PMAIP1/DAXX/ATM/CTSK/HRAS/ATF4/PIK3R1/CTSO/SPTAN1/CTSF/TNFRSF10B/CASP6/CSF2RB	4.5570828926738
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	31/1002	139/9376	2.08687660649923	JUN/CTSD/HSP90AA1/PIK3R3/KRT19/KCNJ5/HSP90AB1/SHC2/ITPR2/PIK3R2/GNAS/KRT18/CALML4/POMC/FOS/ATF6B/PRKACA/CALM3/HSP90B1/HBEGF/EGFR/HRAS/ADCY6/ATF4/CREB3/TGFA/GRB2/PIK3R1/PLCB3/HSPA8/ADCY7	4.46555240426674
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	27/1002	115/9376	2.19692788336371	FGFR1/EGR1/MMP14/PDE4C/ITPR2/MMP15/NR4A2/GNAS/MAFB/FOS/MEF2C/ATF6B/PRKACA/PRKCA/HBEGF/EGFR/WNK2/MMP16/RXRB/ADCY6/ATF4/GCM1/CREB3/GATA3/PLCB3/GNA11/ADCY7	4.46725746351423
NA	NA	hsa04517	IgSF CAM signaling	54/1002	299/9376	1.68994452566439	PLCG2/PMP22/NRP2/FGFR1/NRP1/TUBA1B/MAGI1/CD28/EPB41L1/CABLES1/TUBB/PIK3R3/KIRREL1/AFDN/NCK2/CASK/ITGB2/INPP5D/MTSS2/PIK3R2/MTSS1/PLXNA1/ACTN4/BAIAP2/CD209/PTPRF/PTK2/ITGAM/TUBB2A/PRKCA/RAPGEF6/NPHS1/MYLK/CD84/SRGAP3/PPFIA1/PLXNA3/PTPRD/SRGAP1/F11R/SPTBN5/CADM2/ANK2/UNC5C/GRB2/CASKIN2/PIK3R1/SLITRK4/TJP1/SPTAN1/PLXNA2/CDH1/ESAM/PAK6	4.19403084569896
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1002	110/9376	2.21172201052441	PLCG2/IGF1/FLT1/MKNK1/LDHA/PIK3R3/EPAS1/SERPINE1/TLR4/PIK3R2/HMOX1/PRKCA/TFRC/EIF4E/EGFR/SLC2A1/EGLN1/PDK1/EGLN2/STAT3/PDHB/IFNGR2/EGLN3/PIK3R1/PFKL/ENO2	4.42187246034918
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/1002	44/9376	2.97731809109055	HLA-E/HLA-A/HLA-G/CD28/TNF/HLA-F/HLA-B/HLA-DRB1/ICA1/HSPD1/GAD1/PTPRN2/HLA-DRB3/HLA-DQB2	4.54745629429734
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1002	99/9376	2.17391479666929	JUN/IGF1/CCND1/PIK3R3/SHC2/PIK3R2/CDKN2A/GNAS/PTK2/FOS/PRKACA/DLL1/HBEGF/EGFR/CARM1/HRAS/ADCY6/CDKN2C/GRB2/PIK3R1/ADCY7/RB1/CDK4	4.06165860149162
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1002	76/9376	2.33932135728543	PLCG2/IGF1/CCND1/PIK3R3/SHC2/PDGFB/PIK3R2/CDKN2A/CALML4/CALM3/PRKCA/EGFR/HRAS/TGFA/GRB2/PIK3R1/DDB2/RB1/CDK4	4.05511464394841
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	35/1002	180/9376	1.81947216677756	HLA-E/HLA-A/HLA-G/SRSF7/PIK3R3/CCL2/TNF/SRSF3/NFKBIA/TAPBP/HLA-F/HLA-B/TNFRSF14/PIK3R2/IRF7/HLA-DRB1/SRSF1/IRF9/TNFRSF1A/B2M/SRSF2/TAP1/TAP2/DAXX/PML/CGAS/BST2/IFIH1/SRSF6/IFNGR2/PIK3R1/CARD9/HLA-DRB3/OAS3/HLA-DQB2	3.83993611758988
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	19/1002	78/9376	2.27933875838067	JUN/CD14/C2/C1QA/C4BPB/C1QC/C1QB/TNF/TLR4/ITGB2/SERPING1/CALML4/FOS/ITGAM/CALM3/IRF1/TICAM2/C4BPA/NOD1	3.92456122276473
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	23/1002	103/9376	2.08949092107048	JUN/CCL3/C1QA/C1QC/C1QB/PIK3R3/CCL2/SERPINE1/TNF/TLR4/NFKBIA/PIK3R2/TNFRSF1A/GNAS/FOS/PPP2CB/TGFB2/TLR6/IFNGR2/PIK3R1/PLCB3/GNA11/PPP2CA	3.84578604048154
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	44/1002	250/9376	1.64688223552894	DAB2/HLA-E/FOLR2/HLA-A/CLTC/HLA-G/WWP1/AP2A2/DNM1/IL2RA/SNX6/ASAP2/CHMP4A/HLA-F/HLA-B/SNX3/PSD3/RUFY1/CYTH4/VPS28/CLTA/EPS15/BIN1/RAB11FIP5/EPN2/SNX2/AP2M1/TFRC/PML/EGFR/ASAP3/SNX5/CAPZB/EPN1/ARAP2/HRAS/SNX4/AGAP1/RAB5C/CHMP6/RABEP1/ARFGAP1/HSPA8/GRK3	3.58598127655482
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/1002	56/9376	2.50641573994867	CD14/NAIP/TNF/CR1/TLR4/NFKBIA/ITGB2/CLK1/HSPD1/ITGAM/HSF1/CXCL1/NFKB2/VCP/HSPA8	3.91096494089984
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	23/1002	106/9376	2.03035438556849	FOLR2/FGFR1/IGF1/CCND1/HSP90AA1/PIK3R3/HSP90AB1/NFKBIA/PDGFB/PIK3R2/PDGFC/HSP90B1/ETV5/EGFR/SLC46A1/CCNE1/HRAS/ATF4/CREB3/TGFA/GRB2/PIK3R1/RB1	3.69022383997403
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	39/1002	216/9376	1.68950986915059	JUN/CCL3/CD14/HSP90AA1/PIK3R3/CCL2/NFATC2/TNF/HSP90AB1/TLR4/NFKBIA/ABCA1/NCF4/PIK3R2/IRF7/TNFRSF1A/XBP1/CALML4/HSPD1/PTK2/FOS/CALM3/HSP90B1/PRKCA/CXCL1/STAT3/HRAS/RXRB/MIB1/ATF4/TLR6/PIK3R1/TICAM2/ROCK2/HSPA2/PLCB3/HSPA8/TNFRSF10B/CASP6	3.54627692485252
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	10/1002	30/9376	3.11909514304724	FOLR2/ABCG2/TNF/SHMT1/ABCC1/SLC46A1/ABCC5/ABCC3/ATIC/FPGS	4.02115872201971
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1002	205/9376	1.68887590672314	HLA-E/PLCG2/JUN/HLA-A/CCND1/HLA-G/RBPJ/PIK3R3/TNF/NFKBIA/TAPBP/HLA-F/HLA-B/PIK3R2/IRF7/HLA-DRB1/IRF9/B2M/NFKBIB/PSMC4/TAP1/TAP2/NFKB2/CCNE1/ISG15/STAT3/NFKBIE/SKP2/PIK3R1/PSMC3/HLA-DRB3/OAS3/BLNK/DDB2/HLA-DQB2/RB1/CDK4	3.44955123820425
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	25/1002	122/9376	1.91747652236511	PLCG2/IGF1/CSH1/PIK3R3/SHC2/ITPR2/PIK3R2/GNAS/PTK2/FOS/ATF6B/PRKACA/PRKCA/JUNB/STAT3/HRAS/ADCY6/ATF4/SSTR2/CREB3/GRB2/PIK3R1/PLCB3/GNA11/ADCY7	3.52828085535031
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	54/1002	333/9376	1.51739763715812	SPP1/HLA-E/FN1/HLA-A/CCND1/MAGI1/HLA-G/RBPJ/ITGB5/PIK3R3/CHD4/TNF/COL1A2/MX1/WNT5B/COL4A1/HLA-F/HLA-B/PIK3R2/IRF9/TNFRSF1A/GNAS/PTK2/PRKACA/LAMA3/DLG2/LAMB2/FZD3/SCRIB/PPP2CB/EGFR/ATM/FZD9/CCNE1/ITGA9/PALS1/ISG15/HRAS/IRF1/ATP6V0A1/CREB3/PPP2R3B/MX2/GRB2/FZD5/PIK3R1/FZD7/WNT9B/MAML1/ATP6AP1/RB1/CDK4/PPP2CA/ATP6V0E2	3.32539556374267
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	38/1002	214/9376	1.66157404816535	HLA-E/PLCG2/JUN/HLA-A/HLA-G/GNG12/PIK3R3/NFATC2/TNF/AP1B1/GNG10/TLR4/NFKBIA/ITPR2/TAPBP/HLA-F/HLA-B/PIK3R2/TNFRSF1A/B2M/CALML4/PTK2/FOS/CALM3/PRKCA/CD4/TAP1/TAP2/SKP1/CGAS/ATM/BST2/HRAS/AP1S1/PIK3R1/LIMK1/GNA11/PAK6	3.38643874437822
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1002	98/9376	2.00513259195894	ATP1B1/KCNJ5/SCARB1/ITPR2/NR4A1/NR4A2/GNAS/ATP2B4/CALML4/POMC/CYP11A1/ATF6B/PRKACA/CALM3/PRKCA/ADCY6/ATF4/CREB3/PLCB3/GNA11/ADCY7	3.45988950897609
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/1002	204/9376	1.65128566396619	PLCG2/FN1/CTSL/FGFR1/IGF1/CCND1/TIMP3/ITGB5/PIK3R3/TNF/COL1A2/TLR4/WNT5B/ITPR2/PIK3R2/TWIST1/PTK2/HSPG2/PRKACA/PRKCA/FZD3/HBEGF/EGFR/ARHGEF12/FZD9/STAT3/TGFB2/HRAS/SMO/ANK2/GRB2/FZD5/PIK3R1/ROCK2/FZD7/WNT9B	3.25317630211528
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	29/1002	155/9376	1.75071791900071	CCND1/SCARB1/WNT5B/ITPR2/NR4A1/CDKN2A/GNAS/POMC/CYP11A1/ATF6B/PRKACA/CDKN2B/FZD3/KMT2A/EGFR/FZD9/CCNE1/ADCY6/CDKN2C/ATF4/CREB3/FZD5/PLCB3/FZD7/WNT9B/GNA11/ADCY7/RB1/CDK4	3.25991773753967
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	20/1002	95/9376	1.96995482718773	JUN/CCL3/CTSL/FLT1/CD28/CCL2/TNF/TLR4/ITGB2/HLA-DRB1/FOS/CXCL1/TGFB2/CTSK/ATP6V0A1/ACP5/HLA-DRB3/HLA-DQB2/ATP6AP1/ATP6V0E2	3.28676721072191
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/1002	157/9376	1.72841577990516	STAB1/C1QA/C1QC/ITGB5/C1QB/ALOX5/NFATC2/ADAM9/GAS6/PLA2G15/ABCA1/SLC16A1/LRP1/TIMD4/S1PR1/PTK2/DUSP2/EPOR/PROS1/SIRPA/VPS11/SLC2A1/ATP2A2/VPS16/RAB5C/DUSP8/ANO5/DOCK1/DNMT3A	3.18375972746272
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/1002	109/9376	1.88862641689099	PIK3R3/PYGL/TNF/NFKBIA/PCK2/PIK3R2/TNFRSF1A/TBC1D4/PTPRF/RPS6KA1/PPP1R3C/PYGM/PPP1R3B/SLC2A1/SREBF1/SLC27A3/PRKAG1/STAT3/MLXIP/CREB3/PIK3R1/PTPA	3.22786905111364
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	16/1002	70/9376	2.13880809808954	JUN/PIK3R3/EPAS1/PDGFB/PIK3R2/SLC2A1/EGLN1/EGLN2/TGFB2/HRAS/TGFA/FLCN/GRB2/EGLN3/PIK3R1/PAK6	3.30804236940731
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/1002	90/9376	1.97542692392992	JUN/CD28/PIK3R3/NFATC2/TLR4/NFKBIA/PIK3R2/FOS/NFKBIB/CD4/EGFR/STAT3/HRAS/NFKBIE/BATF2/IFNGR2/PIK3R1/TICAM2/BATF	3.21628610611209
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	29/1002	160/9376	1.69600798403194	SIGLEC1/HLA-E/HLA-A/HLA-G/CD28/LRRC4/CD99/ITGB2/HLA-F/HLA-B/HLA-DRB1/PTPRF/ITGAM/CD4/CLDN7/CLDN23/CD276/PTPRD/ITGA9/F11R/OCLN/SLITRK4/HLA-DRB3/SDC3/CLDN19/CDH1/ESAM/HLA-DQB2/PTPRM	3.07153876280846
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1002	91/9376	1.95371893575486	PLCG2/JUN/LILRB4/PIK3R3/LILRB5/NFATC2/NFKBIA/INPP5D/PIK3R2/LILRB3/FOS/NFKBIB/LILRA6/HRAS/NFKBIE/GRB2/PIK3R1/BLNK/LILRA4	3.16230072991921
NA	NA	hsa04518	Integrin signaling	28/1002	154/9376	1.70132462348031	SPP1/FN1/IGF1/FLT1/CCND1/ITGB5/PIK3R3/COL1A2/NCK2/PDGFB/ITGB2/COL4A1/ICAM4/PIK3R2/PDGFC/ACTN4/PTK2/ITGAM/TLN1/LAMA3/LAMB2/EGFR/ITGA9/VEGFB/FBN1/PIK3R1/PGF/CDH1	3.03542781462114
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1002	73/9376	2.05091187488038	PLCG2/CCND1/PIK3R3/PIK3R2/CDKN2A/PRKCA/EGFR/STAT3/HRAS/RXRB/TGFA/GRB2/PIK3R1/DDB2/RB1/CDK4	3.11795066912933
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/1002	275/9376	1.49716566866267	MT-CO3/MT-ATP6/MT-ND1/EGR1/C1QA/MT-CO1/MT-ND5/TUBA1B/MT-CYB/MT-ND4/C1QC/RYR3/C1QB/TUBB/MT-ND2/PIK3R3/TNF/SLC25A4/C9/NCF4/ITPR2/NDUFS1/PIK3R2/GRIN2C/NDUFS3/MT-CO2/NDUFA7/MT-ND6/RYR1/NDUFA3/NDUFA6/TUBB2A/ATF6B/PRKACA/PSMC4/MT-ND4L/COX4I2/PSMA2/ATF4/CREB3/PIK3R1/PSMA6/PSMC3/HSPA8	2.8945159136552
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	19/1002	93/9376	1.91170347477089	JUN/MAF/RBPJ/IL12RB2/NFATC2/IL2RA/NFKBIA/HLA-DRB1/FOS/NFKBIB/DLL1/CD4/NFKBIE/GATA3/IFNGR2/HLA-DRB3/MAML1/HLA-DQB2/IL4R	3.05635593604152
NA	NA	hsa04981	Folate transport and metabolism	9/1002	31/9376	2.71663125362179	FOLR2/SLCO2B1/ABCG2/SHMT1/ABCC1/SLC46A1/ABCC5/ABCC3/FPGS	3.31147308802434
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/1002	156/9376	1.67951276933313	CCND1/RSAD2/PIK3R3/YWHAE/TNF/MX1/SCARB1/NFKBIA/IFIT1/PIK3R2/IRF7/IRF9/TNFRSF1A/CLDN7/CLDN23/PPP2CB/EGFR/STAT3/HRAS/OCLN/MX2/GRB2/PIK3R1/OAS3/CLDN19/RB1/CDK4/PPP2CA	2.96038013768271
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	55/1002	362/9376	1.4216870127149	SPP1/CSF1R/FN1/FGFR1/IGF1/CSH1/FLT1/CCND1/MAGI1/GNG12/ITGB5/HSP90AA1/PIK3R3/YWHAE/IL2RA/COL1A2/GNG10/HSP90AB1/TLR4/PDGFB/COL4A1/PCK2/LPAR6/PIK3R2/EFNA2/NR4A1/PDGFC/PTK2/ATF6B/HSP90B1/PRKCA/LAMA3/LAMB2/EPOR/EIF4E/PPP2CB/EGFR/CCNE1/ITGA9/HRAS/EPHA2/VEGFB/ATF4/CREB3/PPP2R3B/TGFA/GRB2/PIK3R1/PGF/EFNA4/BRCA1/CDK4/IL4R/PPP2CA/SGK3	2.83034094902263
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1002	101/9376	1.85292780775084	PLCG2/JUN/FN1/EGR1/CCND1/PIK3R3/CCL2/SERPINE1/TNF/COL1A2/COL4A1/PIK3R2/PRKCA/STAT3/TGFB2/HRAS/VEGFB/PIK3R1/PLCB3/CDK4	2.98104836567183
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	34/1002	203/9376	1.56723007187595	SPP1/JUN/FN1/IGF1/FLT1/CCND1/ITGB5/PIK3R3/COL1A2/SHC2/PDGFB/COL4A1/PIK3R2/PDGFC/ACTN4/PTK2/TLN1/PRKCA/ZYX/LAMA3/LAMB2/ARHGAP5/MYLK/EGFR/ITGA9/EMP2/HRAS/VEGFB/GRB2/PIK3R1/ROCK2/PGF/DOCK1/PAK6	2.82621104904789
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1002	130/9376	1.72749884845693	JUN/GNG12/PIK3R3/COL1A2/GNG10/SHC2/NFKBIA/COL4A1/PIK3R2/GNAS/FOS/ATF6B/PRKACA/PRKCA/EGFR/HRAS/VEGFB/ADCY6/ATF4/CREB3/GRB2/PIK3R1/PLCB3/ADCY7	2.8892163410624
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/1002	116/9376	1.77465758138895	PLCG2/PIK3R3/AFDN/NCF4/CD99/ITGB2/PIK3R2/ACTN4/PTK2/ITGAM/PRKCA/CTNND1/CLDN7/CLDN23/SIPA1/ARHGAP5/F11R/OCLN/PIK3R1/ROCK2/CLDN19/ESAM	2.90393103079631
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1002	89/9376	1.89248469353428	TUBA1B/TUBB/HTR2B/PDGFB/ITPR2/PDGFC/GNAS/TUBB2A/PRKACA/PRKCA/EGFR/HRAS/ADCY6/GRB2/PLCB3/TJP1/GNA11/ADCY7	2.92624764884742
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1002	110/9376	1.78639085465433	NBL1/TNF/RGMA/BMP2/ID3/ID2/CDKN2B/TFRC/HFE/SKP1/PPP2CB/RGMB/TGFB2/LTBP1/BMPR1A/FBN1/HAMP/SMAD7/NOG/ID1/PPP2CA	2.86973417422823
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	35/1002	212/9376	1.54483485858472	CSF1R/FGFR1/IGF1/FLT1/MAGI1/ENAH/PIK3R3/AFDN/PDGFB/ITGB2/PIK3R2/EFNA2/PDGFC/GNAS/CALML4/ITGAM/TLN1/CALM3/PRKCA/RAPGEF6/CTNND1/SIPA1/EGFR/P2RY1/HRAS/EPHA2/VEGFB/ADCY6/PIK3R1/PGF/PLCB3/CDH1/ADCY7/ID1/EFNA4	2.77551319849422
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1002	63/9376	2.07939676203149	POLE/POLR2J3/POLR2A/GTF2H2/GTF2H1/POLD4/CDK7/POLR2F/POLD3/POLD1/DDB2/GTF2H3/XPA/ERCC5	2.97344291272282
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	34/1002	205/9376	1.55194002239424	MT-CO3/MT-ATP6/MT-ND1/MT-CO1/MT-ND5/MT-CYB/MT-ND4/CTSD/MT-ND2/PIK3R3/COL1A2/PDK4/SLC25A4/NCF4/NDUFS1/PIK3R2/TBC1D4/NDUFS3/MT-CO2/NDUFA7/MT-ND6/NDUFA3/NDUFA6/PARP1/PRKCA/MT-ND4L/COX4I2/SLC2A1/TGFB2/PDHB/ATP2A2/PIK3R1/PTPA/PLCB3	2.76384377662625
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/1002	154/9376	1.64056302978459	JUN/CCND1/RYR3/NFATC2/EEF2K/KCNJ5/ITPR2/RCAN1/GNAS/CACNB4/CALML4/RYR1/FOS/MEF2C/PRKACA/CALM3/PRKCA/MYLK/EGFR/PRKAG1/HRAS/ADCY6/TRPM2/ROCK2/PLCB3/KCNJ2/ADCY7	2.77244341996315
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/1002	45/9376	2.28733643823464	ABCG2/ABCA6/ABCA9/ABCA1/ABCC1/TAP1/TAP2/ABCD4/ABCC5/ABCC3/ABCA8	2.99424439356014
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/1002	39/9376	2.39930395619018	HLA-E/HLA-A/HLA-G/CD28/TNF/HLA-F/HLA-B/HLA-DRB1/HLA-DRB3/HLA-DQB2	3.02896117625099
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/1002	105/9376	1.78234008174128	PLCG2/JUN/PIK3R3/NFATC2/TNF/NFKBIA/ITPR2/EGR2/PIK3R2/IRF9/CALML4/CD209/CALM3/NFKB2/ARHGEF12/HRAS/IRF1/PIK3R1/CARD9/EGR3	2.78855979038734
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	38/1002	238/9376	1.49402036263607	F13A1/PLCG2/JUN/C2/C1QA/NRP1/CFD/C1QC/RPS4Y1/C1QB/PIK3R3/CCL2/TNF/RPS9/MX1/TLR4/C9/NFKBIA/TLR7/FCGR2A/PIK3R2/IRF9/TNFRSF1A/FOS/NFKBIB/PRKCA/C3AR1/HBEGF/CFB/EGFR/CGAS/IFIH1/ISG15/STAT3/ADAR/MX2/PIK3R1/OAS3	2.67030440691397
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/1002	163/9376	1.60738645408569	JUN/PIK3R3/NFATC2/TNF/TLR4/NFKBIA/EGR2/PIK3R2/IRF7/HSPG2/FOS/ATF6B/PRKCA/IFIH1/CCNE1/STAT3/TGFB2/HRAS/DDX3X/ATF4/CREB3/GRB2/PIK3R1/TICAM2/EGR3/DDB2/ATP6AP1/RB1	2.7058977989104
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/1002	78/9376	1.91944316495215	JUN/TNF/CR1/TLR4/NFKBIA/NCF4/ITGB2/FCGR2A/HLA-DRB1/FOS/NFKBIB/ITGAM/TGFB2/IFNGR2/HLA-DRB3/HLA-DQB2	2.8205281580577
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/1002	65/9376	2.01541532319975	SCARB1/ITPR2/NR4A1/GNAS/POMC/CYP11A1/ATF6B/PRKACA/ADCY6/ATF4/CREB3/PLCB3/GNA11/ADCY7	2.84154964831342
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1002	18/9376	3.11909514304724	NEU1/FUCA1/MAN2B1/HEXA/HEXB/MAN2B2	3.11277843382511
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1002	53/9376	2.1186306632019	CLTC/AP2A2/DNM1/ATP1B1/GNAS/ATP2B4/CLTA/PRKACA/PRKCA/AP2M1/ADCY6/PLCB3	2.82487888957783
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	18/1002	93/9376	1.81108750241453	JUN/EGR1/MMP14/ITPR2/GNAS/CALML4/PRKACA/CALM3/PRKCA/HBEGF/EGFR/HRAS/ADCY6/ATF4/GRB2/PLCB3/GNA11/ADCY7	2.71905523150133
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1002	93/9376	1.81108750241453	FN1/CCND1/PIK3R3/BIRC7/NFKBIA/COL4A1/PIK3R2/PTK2/LAMA3/CDKN2B/LAMB2/CCNE1/RXRB/SKP2/PIK3R1/DDB2/RB1/CDK4	2.71905523150133
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/1002	136/9376	1.65128566396619	JUN/CCND1/CD28/PIK3R3/IL2RA/MX1/TLR4/NFKBIA/TLR7/PIK3R2/IRF7/IRF9/CD209/FOS/NFKBIB/IFIH1/CCNE1/STAT3/ADAR/MX2/PIK3R1/OAS3/HSPA8/CDK4	2.64641535596381
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/1002	173/9376	1.56856229737058	RSAD2/PIK3R3/CCL2/TNF/MX1/SLC25A4/TLR4/NFKBIA/TLR7/DNAJB1/PIK3R2/IRF7/HLA-DRB1/IRF9/TNFRSF1A/NFKBIB/PRKCA/PML/IFIH1/ADAR/IFNGR2/MX2/PIK3R1/FDPS/HLA-DRB3/OAS3/HLA-DQB2/TNFRSF10B/CDK4	2.61089507196031
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1002	73/9376	1.92272988270035	FGFR1/IGF1/CCND1/PIK3R3/PDGFB/PIK3R2/PDGFC/CDKN2A/EGFR/HRAS/PIK3R1/CDH1/DDB2/RB1/CDK4	2.73764748877605
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	32/1002	196/9376	1.52772007006395	HLA-E/PLCG2/JUN/HLA-A/CCND1/HLA-G/GNG12/PIK3R3/CD200R1/NFATC2/GNG10/NFKBIA/PDGFB/ITPR2/HLA-F/CCR1/HLA-B/RCAN1/PIK3R2/IRF7/IRF9/TNFRSF1A/CALML4/FOS/CALM3/CXCL1/STAT3/HRAS/PIK3R1/MAP1LC3A/RB1/CDK4	2.58263675357905
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	16/1002	80/9376	1.87145708582834	PLCG2/IGF1/PIK3R3/GAS6/SHC2/PDGFB/PIK3R2/PDGFC/PRKCA/EIF4E/EGFR/STAT3/HRAS/TGFA/GRB2/PIK3R1	2.70767142776025
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	20/1002	109/9376	1.71693310626454	JUN/HSP90AA1/NFATC2/IL2RA/HSP90AB1/NFKBIA/HLA-DRB1/FOS/NFKBIB/CD4/EBI3/STAT3/RXRB/NFKBIE/GATA3/IL27RA/IFNGR2/HLA-DRB3/HLA-DQB2/IL4R	2.60420593113422
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1002	75/9376	1.87145708582834	IGF1/CCND1/SERPINE1/CDKN2A/SESN1/PMAIP1/ATM/CCNE1/CCNG2/ZMAT3/GTSE1/STEAP3/DDB2/TNFRSF10B/CDK4	2.62098681191812
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1002	69/9376	1.89857965228962	JUN/FOSB/GRIA4/GRIN2C/GNAS/CALML4/FOS/ATF6B/PRKACA/CALM3/PRKCA/ARC/ATF4/CREB3	2.59136917950254
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/1002	133/9376	1.61817717947563	IGF1/CCND1/PIK3R3/KLF2/DEPP1/PCK2/PIK3R2/S1PR1/CSNK1E/CDKN2B/EGFR/ATM/PRKAG1/STAT3/TGFB2/HRAS/SKP2/CCNG2/GRB2/PIK3R1/FOXO4/PLK2/SGK3	2.4836210572625
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1002	70/9376	1.87145708582834	HLA-E/HLA-A/CCND1/HLA-G/CD28/ITGB2/HLA-F/HLA-B/HLA-DRB1/EIF4G1/EIF4G3/DMD/HLA-DRB3/HLA-DQB2	2.53143349426176
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	26/1002	157/9376	1.54961414750118	CCND1/SERPINE1/YWHAE/WNT5B/ITGB2/BMP2/ID2/CSNK1E/DLG2/FZD3/SCRIB/PPP2CB/LIMD1/FZD9/PALS1/TGFB2/DLG5/BMPR1A/SAV1/FZD5/SMAD7/FZD7/WNT9B/CDH1/ID1/PPP2CA	2.40225354355425
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	9/1002	38/9376	2.2161991805862	HEXA/GALE/AMDHD2/HEXB/GALT/UGP2/PGM1/NAGK/RENBP	2.59849921924956
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1002	15/9376	3.11909514304724	HEXA/B3GALT4/HEXB/ST6GALNAC6/SLC33A1	2.84110957436536
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	55/1002	388/9376	1.32641932629586	MT-CO3/MT-ATP6/MT-ND1/DKK2/MT-CO1/MT-ND5/TUBA1B/MT-CYB/MT-ND4/RYR3/TUBB/MT-ND2/PIK3R3/TNF/BACE2/SLC39A1/SLC25A4/WNT5B/ITPR2/NDUFS1/SLC39A7/PIK3R2/GRIN2C/LRP1/TNFRSF1A/SLC39A12/NDUFS3/MT-CO2/XBP1/NDUFA7/CALML4/MT-ND6/NDUFA3/NDUFA6/TUBB2A/CALM3/CSNK1E/PSMC4/FZD3/MT-ND4L/COX4I2/PSMA2/FZD9/PSEN2/HRAS/ATP2A2/NAE1/ATF4/FZD5/PIK3R1/PSMA6/PSMC3/PLCB3/FZD7/WNT9B	2.27150248210139
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1002	107/9376	1.66157404816535	LDHA/PYGL/ITPR2/PCK2/GNAS/CALML4/PRKACA/CALM3/PYGM/SLC2A1/PRKAG1/PDHB/ATF4/CREB3/PLCB3/PHKA1/PFKL/ACACA/PHKB	2.38071237312117
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	18/1002	100/9376	1.68431137724551	CSF1R/CCL3/CCL4/CCL2/TNF/IL2RA/IL34/CCR1/TNFRSF14/CCL13/TNFRSF1A/CCL8/TNFRSF10D/CXCL1/CCL14/CCL18/ACKR3/TNFRSF10B	2.37972301748858
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/1002	45/9376	2.07939676203149	HLA-E/HLA-A/HLA-G/CD28/TNF/HLA-F/HLA-B/HLA-DRB1/HLA-DRB3/HLA-DQB2	2.51059288554891
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1002	122/9376	1.61068027878669	JUN/CD28/PIK3R3/NFATC2/TNF/NCK2/NFKBIA/PIK3R2/FOS/NFKBIB/CD4/PPP2CB/TEC1/HRAS/NFKBIE/PPP2R3B/GRB2/PIK3R1/CDK4/PAK6/PPP2CA	2.34845413899935
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1002	122/9376	1.61068027878669	PLCG2/CCND1/PIK3R3/ATP1B1/DIO2/RCAN1/PIK3R2/TBC1D4/PRKACA/PRKCA/SLC2A1/MED16/KAT2A/HRAS/RXRB/ATP2A2/PIK3R1/PLCB3/MED17/PFKL/PFKFB2	2.34845413899935
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/1002	138/9376	1.55954757152362	MKNK1/PIK3R3/PYGL/SHC2/PCK2/PIK3R2/CALML4/PTPRF/FLOT1/PRKACA/CALM3/PPP1R3C/PYGM/PPP1R3B/EIF4E/SREBF1/PRKAG1/HRAS/GRB2/PIK3R1/PHKA1/ACACA/PHKB	2.29055434484339
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/1002	66/9376	1.843101675437	JUN/MAF/IL12RB2/TNF/TLR4/HLA-DRB1/STAT3/TGFB2/GATA3/IFNGR2/HLA-DRB3/HLA-DQB2/IL4R	2.37755241630025
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/1002	170/9376	1.48615709756957	PLCG2/CCND1/PIK3R3/SHC2/WNT5B/PIK3R2/HMOX1/CDKN2A/PRKCA/FZD3/SMARCB1/EGFR/FZD9/TGFB2/HRAS/TGFA/GRB2/FZD5/PIK3R1/PBRM1/FZD7/WNT9B/DDB2/GSTA4/GSTM3/RB1/CDK4	2.21268008292969
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	24/1002	148/9376	1.51739763715812	JUN/FGFR1/IGF1/CCND1/PIK3R3/SHC2/WNT5B/PIK3R2/FOS/DLL1/FZD3/EGFR/NFKB2/FZD9/HRAS/GRB2/FZD5/PIK3R1/FZD7/WNT9B/DDB2/RB1/BRCA1/CDK4	2.19459571309823
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	29/1002	187/9376	1.45112982590968	CTSB/JUN/ANTXR1/HSP90AA1/CCL2/YWHAE/NAIP/TNF/GSDMD/HSP90AB1/TLR4/NFKBIA/ITPR2/IRF7/IRF9/NFKBIB/CARD18/RNF31/CXCL1/IFI16/RIPK3/SHARPIN/TRPM2/CARD9/ATG16L1/MAP1LC3A/PLCB3/OAS3/NOD1	2.15546630946967
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1002	75/9376	1.74669328010645	CANX/ATP1B1/ITPR2/GNAS/ATF6B/PRKACA/HSP90B1/PRKCA/GPX3/ADCY6/ATF4/CREB3/PLCB3/ADCY7	2.24574826636087
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/1002	119/9376	1.57265301330113	JUN/MMP14/PIK3R3/CCL2/TNF/NFKBIA/PIK3R2/TNFRSF1A/FOS/ATF6B/JUNB/CXCL1/RHBDF2/RIPK3/IRF1/BAG4/ATF4/CREB3/PIK3R1/RPS6KA4	2.17461770625231
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/1002	157/9376	1.49001360336652	HLA-E/HLA-A/CCND1/HLA-G/SQSTM1/PIK3R3/SERPINE1/NFATC2/SLC25A4/ITPR2/HLA-F/HLA-B/PIK3R2/CDKN2A/RAD50/CALML4/CALM3/CDKN2B/ATM/CCNE1/TGFB2/HRAS/PIK3R1/RB1/CDK4	2.14175148225143
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	25/1002	157/9376	1.49001360336652	JUN/MT-CO3/MT-CO1/MT-CYB/PIK3R3/TNF/NDUFS1/PIK3R2/TNFRSF1A/NDUFS3/MT-CO2/XBP1/NDUFA7/NDUFA3/NDUFA6/FOS/GSK3A/MAP3K11/CEBPA/COX4I2/SREBF1/PRKAG1/MLXIP/ATF4/PIK3R1	2.14175148225143
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	17/1002	97/9376	1.63993662160216	GRIA4/GNG12/RYR3/GNG10/KCNJ5/GRIN2C/GNAS/CALML4/RYR1/FOS/PRKACA/CALM3/PRKCA/PER3/ADCY6/PLCB3/ADCY7	2.19141820241243
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1002	142/9376	1.51561665401591	JUN/CTSL/SQSTM1/HSP90AA1/PIK3R3/CCL2/KLF2/TNF/HSP90AB1/PDGFB/PIK3R2/HMOX1/TNFRSF1A/CALML4/PTK2/FOS/MEF2C/CALM3/HSP90B1/BMPR1A/PIK3R1/GSTA4/GSTM3	2.14155481019007
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1002	48/9376	1.94943446440452	SCARB1/CHMP4A/LAMP1/HSPG2/CLDN7/CLDN23/TGOLN2/EGFR/OCLN/CLDN19	2.2811002031837
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	37/1002	253/9376	1.3684567623646	PLCG2/JUN/CD14/SQSTM1/PIK3R3/NAIP/TNF/TLR4/NFKBIA/ITPR2/PIK3R2/H3-7/CYTH4/TNFRSF1A/ACTN4/H3C12/PTK2/GSK3A/NFKBIB/TLN1/SKP1/RNF31/EGFR/CGAS/FNBP1L/ATM/SHARPIN/PIK3R1/ROCK2/ATG16L1/FOXO4/MAP1LC3A/PLCB3/TECPR1/SEPTIN8/DOCK1/NOD1	2.05509061271194
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	17/1002	98/9376	1.62320257444295	PLCG2/PIK3R3/ITPR2/INPP5D/PIK3R2/CDS1/CALML4/PI4K2A/CALM3/PRKCA/PIP4K2B/INPP4B/DGKZ/ITPK1/PIK3R1/PLCB3/DGKH	2.14520160477509
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	35/1002	238/9376	1.37607138663849	PLCG2/CSF1R/FGFR1/IGF1/FLT1/GNG12/RGL1/PIK3R3/GNG10/AFDN/SHC2/PDGFB/PIK3R2/EFNA2/PDGFC/RGL2/CALML4/PRKACA/CALM3/PRKCA/RASA3/EGFR/RASA4/HRAS/RALBP1/EPHA2/VEGFB/TGFA/RAB5C/GRB2/PIK3R1/FOXO4/PGF/EFNA4/PAK6	2.03276050342641
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1002	144/9376	1.49456642271014	FGFR1/IGF1/PIK3R3/WNT5B/KLF4/ID3/PIK3R2/ID2/ZFHX3/DUSP9/FZD3/FZD9/STAT3/HRAS/BMPR1A/GRB2/FZD5/PIK3R1/DLX5/FZD7/WNT9B/ID1/SETDB1	2.06876422116613
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/1002	99/9376	1.60680658884252	C2/C1QA/CFD/C1QC/C1QB/CFI/KRT19/ITGB2/FCGR2A/HLA-DRB1/KRT18/ITGAM/C3AR1/CFB/PTAFR/HLA-DRB3/HLA-DQB2	2.09950603570792
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1002	71/9376	1.7133057828006	FGFR1/LDHA/PIK3R3/IDH1/PIK3R2/EGFR/SLC2A1/PDK1/HRAS/PDHB/TIGAR/PIK3R1/PFKL	2.08689092833562
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1002	50/9376	1.87145708582834	HBA2/HBA1/CCL2/TNF/CR1/GYPC/TLR4/ITGB2/LRP1/TGFB2	2.1371564847249
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	29/1002	193/9376	1.40601698158088	PLCG2/CCL3/CCL4/GNG12/PIK3R3/CCL2/GNG10/SHC2/NFKBIA/CCR1/PIK3R2/CCL13/CCL8/PTK2/GSK3A/NFKBIB/PRKACA/CXCL1/CCL14/STAT3/HRAS/CCL18/ADCY6/GRB2/PIK3R1/ROCK2/PLCB3/ADCY7/GRK3	1.97144007827432
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	30/1002	201/9376	1.39660976554354	CSF1R/CD14/MAF/NUPR1/IGF1/FLT1/FUS/MLF1/H3-7/HPGD/HHEX/ID2/H3C12/TSPAN7/PTK2/ITGAM/MEF2C/BMP2K/CEBPA/ETV5/PML/KMT2A/ETV1/ATM/RXRB/NFKBIZ/MLLT1/TAF15/CDKN2C/DDB2	1.96612631710313
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1002	86/9376	1.63208466787356	PLCG2/JUN/PIK3R3/NCK2/SHC2/PIK3R2/PTK2/PRKCA/HBEGF/EGFR/HRAS/TGFA/GRB2/PIK3R1/PAK6	2.03689970522631
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1002	101/9376	1.57498863658821	WNT5B/GNAS/CALML4/POMC/PRKACA/CALM3/PRKCA/FZD3/FZD9/HRAS/ADCY6/CREB3/FZD5/PLCB3/FZD7/WNT9B/ADCY7	2.00962956044445
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/1002	109/9376	1.54523979563808	SPP1/JUN/CCL3/CD14/CCL4/PIK3R3/TNF/TLR4/NFKBIA/TLR7/PIK3R2/IRF7/IRF9/FOS/CTSK/TLR6/PIK3R1/TICAM2	1.9805428111548
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	42/1002	300/9376	1.31001996007984	CSF1R/JUN/HSPB1/CD14/FGFR1/IGF1/FLT1/MKNK1/GNG12/TNF/PDGFB/EFNA2/NR4A1/PDGFC/TNFRSF1A/CACNB4/RPS6KA1/FOS/DUSP2/MEF2C/PRKACA/PRKCA/DUSP9/MAP3K11/DAXX/EGFR/NFKB2/MAP3K9/TGFB2/HRAS/EPHA2/VEGFB/ATF4/TGFA/GRB2/PGF/STMN1/DUSP8/RPS6KA4/HSPA8/EFNA4/TAOK2	1.88780034206995
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/1002	140/9376	1.47043056743656	SPP1/EGR1/CCND1/GNG12/RYR3/SERPINE1/KLF2/GNG10/ITPR2/CALML4/RYR1/MEF2C/PRKACA/CALM3/MYLK/PRKAG1/HRAS/ADCY6/MAP1LC3A/PLCB3/CDH1/ADCY7	1.93986099084837
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	38/1002	268/9376	1.32677927726636	MT-CO3/MT-ATP6/MT-ND1/MT-CO1/MT-ND5/TUBA1B/MT-CYB/MT-ND4/RYR3/TUBB/MT-ND2/SLC39A1/SLC25A4/ITPR2/NDUFS1/SLC39A7/SLC39A12/NDUFS3/GNAS/MT-CO2/XBP1/NDUFA7/CALML4/MT-ND6/NDUFA3/NDUFA6/TUBB2A/PRKACA/CALM3/PSMC4/MT-ND4L/DAXX/COX4I2/PSMA2/ATF4/PSMA6/UBA7/PSMC3	1.87742853600322
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	20/1002	125/9376	1.49716566866267	CTSD/PIK3R3/TNF/ABCC1/PIK3R2/SGPP1/TNFRSF1A/S1PR1/PRKCA/SPTLC3/PPP2CB/ORMDL2/HRAS/PPP2R3B/PIK3R1/ROCK2/PLCB3/ADORA3/PPP2CA/S1PR2	1.9355964543712
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1002	73/9376	1.66636589834031	MX1/CHMP4A/BICD1/FEZ1/CD4/SMARCB1/BST2/KAT2A/MLLT1/NELFE/MX2/CHMP6/BICD2	1.97704112806949
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	23/1002	149/9376	1.44441318704872	MT-ND1/MT-ND5/MT-ND4/GRIA4/GNG12/MT-ND2/GABRA3/GNG10/GABRB2/KCNJ5/ITPR2/NDUFS1/NDUFS3/NDUFA7/MT-ND6/NDUFA3/NDUFA6/PRKACA/PRKCA/MT-ND4L/ADCY6/PLCB3/ADCY7	1.89148469634162
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/1002	181/9376	1.39583815793827	MRC1/CD14/CTSD/TNF/CR1/TLR4/ITGB2/FCGR2A/HLA-DRB1/TNFRSF1A/CALML4/HSPD1/CD209/LAMP1/ITGAM/CALM3/ARHGEF12/TGFB2/HSPA9/ATP6V0A1/TLR6/IFNGR2/RAB5C/CARD9/HLA-DRB3/HLA-DQB2/ATP6AP1	1.86009060094773
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	36/1002	254/9376	1.32622943090198	PLCG2/FGFR1/FLT1/RYR3/NFATC2/SLC25A4/HTR2B/MCOLN1/PDGFB/ITPR2/GRIN2C/HRH1/PDGFC/GNAS/ATP2B4/CALML4/RYR1/PRKACA/CALM3/PRKCA/TRDN/MYLK/TPCN1/EGFR/ADRB3/ATP2A2/VEGFB/PDE1B/TGFA/PTAFR/PLCB3/GNA11/ORAI3/PHKA1/ADCY7/PHKB	1.82325739432729
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/1002	120/9376	1.48157019294744	PLCG2/JUN/PIK3R3/YWHAE/SHC2/NFKBIA/PIK3R2/MAGED1/CALML4/RPS6KA1/NFKBIB/CALM3/PSEN2/HRAS/NFKBIE/ATF4/GRB2/PIK3R1/BEX3	1.8365026904846
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/1002	26/9376	2.15937356057117	SCARB1/ABCC1/SLC46A1/ABCD4/TCN2/PLB1	2.04765733457996
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1002	90/9376	1.55954757152362	IGF1/PIK3R3/PIK3R2/SESN1/ATF6B/PRKACA/EHMT2/EIF4E/PRKAG1/HRAS/ADCY6/ATF4/CREB3/PIK3R1/ADCY7	1.84500246594534
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/1002	68/9376	1.65128566396619	CSF1R/CD14/CCND1/PIK3R3/PIK3R2/ITGAM/CEBPA/PML/STAT3/HRAS/GRB2/PIK3R1	1.86445028863012
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1002	76/9376	1.60058829709003	ATP1B1/ITPR2/GNAS/CALML4/PRKACA/CALM3/PRKCA/MYLK/ADCY6/SSTR2/PLCB3/KCNJ2/ADCY7	1.81842422303342
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	16/1002	99/9376	1.51228855420472	PLCG2/IGF1/PIK3R3/HTR2B/ITPR2/PIK3R2/HRH1/GNAS/CALML4/PRKACA/CALM3/PRKCA/ADCY6/PIK3R1/PLCB3/ADCY7	1.7724806080773
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/1002	170/9376	1.37607138663849	JUN/TUBA1B/CCND1/MAGI1/AFDN/ACTN4/PRKACA/RAPGEF6/DLG2/CLDN7/CLDN23/SCRIB/ARHGAP17/PPP2CB/PRKAG1/PALS1/F11R/OCLN/RAB13/CGNL1/ROCK2/TJP1/CLDN19/CDK4/PPP2CA	1.71163944974733
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	32/1002	227/9376	1.31908869485698	JUN/MT-CO3/MT-ATP6/MT-ND1/MT-CO1/MT-ND5/MT-CYB/MT-ND4/EPHX1/MT-ND2/PIK3R3/SLC25A4/NFKBIA/NDUFS1/PIK3R2/HMOX1/NDUFS3/MT-CO2/NDUFA7/MT-ND6/NDUFA3/PTK2/NDUFA6/FOS/MT-ND4L/COX4I2/EGFR/HRAS/GRB2/PIK3R1/GSTA4/GSTM3	1.68341252120682
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/1002	77/9376	1.57980143608886	CCND1/PIK3R3/PIK3R2/CDKN2A/EGFR/STAT3/TGFB2/RALBP1/TGFA/PIK3R1/DDB2/RB1/CDK4	1.76709356808536
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1002	77/9376	1.57980143608886	CCND1/PIK3R3/SHC2/NFKBIA/PIK3R2/CDKN2A/TGFB2/HRAS/GRB2/PIK3R1/DDB2/RB1/CDK4	1.76709356808536
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1002	41/9376	1.82581179105204	RAD50/ATM/TOP3A/POLD4/RAD51C/POLD3/POLD1/BRCA1	1.83302702258835
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/1002	41/9376	1.82581179105204	CCND1/CDKN2A/HBEGF/EGFR/HRAS/CDH1/RB1/CDK4	1.83302702258835
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1002	63/9376	1.63381174159617	COLGALT1/EHMT2/AASS/KMT2A/PLOD2/PIPOX/GCDH/SETDB2/PLOD1/PLOD3/SETDB1	1.74597802897121
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1002	71/9376	1.58151303027747	PLCG2/JUN/NFKBIA/HBEGF/EGFR/CXCL1/F11R/ATP6V0A1/TJP1/ATP6AP1/NOD1/ATP6V0E2	1.70131000877398
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/1002	133/9376	1.40711059084838	GRIA4/GNG12/SCN1A/GNG10/KCNJ5/ITPR2/GNAS/CALML4/FOS/GSK3A/ATF6B/PRKACA/CALM3/PRKCA/PPP2CB/ATF4/CREB3/PPP2R3B/PLCB3/PPP2CA	1.63562886116773
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1002	149/9376	1.38161261369878	PLCG2/DNM1/PIK3R3/SHC2/PDGFB/LPAR6/PIK3R2/PDGFC/CYTH4/GNAS/PRKCA/EGFR/HRAS/ADCY6/DGKZ/GRB2/AGPAT1/PIK3R1/AGPAT2/PLCB3/ADCY7/DGKH	1.62419667052551
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/1002	248/9376	1.28285364754362	JUN/CD14/CYFIP1/TUBA1B/HSP90AA1/TUBB/NAIP/TNF/GSDMD/HSP90AB1/DYNLRB1/TLR4/NFKBIA/CYTH4/TNFRSF1A/RHOB/FOS/TUBB2A/HSP90B1/RILP/SKP1/VPS11/RIPK3/HRAS/GCC2/VPS16/TLR6/RAB5C/ROCK2/DCTN4/DYNC2H1/NOD1/TNFRSF10B/PLEKHM1	1.56153897697626
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	30/1002	217/9376	1.29363393029609	JUN/CCND1/EPHX1/HSP90AA1/PIK3R3/HSP90AB1/KLF4/PIK3R2/GNAS/RPS6KA1/FOS/ATF6B/PRKACA/HSP90B1/PRKCA/DLL1/EGFR/ADRB3/STAT3/HRAS/RXRB/ADCY6/ATF4/CREB3/GRB2/PIK3R1/ADCY7/GSTA4/GSTM3/RB1	1.5137881327817
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1002	44/9376	1.70132462348031	GNAS/PRKACA/NSF/ADCY6/CREB3/RAB5C/DCTN4/DYNC2H1	1.61291351541334
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	20/1002	138/9376	1.35612832306402	MT-CO3/MT-ATP6/MT-ND1/MT-CO1/MT-ND5/MT-CYB/MT-ND4/MT-ND2/NDUFS1/NDUFS3/MT-CO2/NDUFA7/MT-ND6/NDUFA3/NDUFA6/MT-ND4L/COX4I2/ATP6V0A1/ATP6AP1/ATP6V0E2	1.45784079715489
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/1002	138/9376	1.35612832306402	JUN/FN1/PIK3R3/CCL2/NFATC2/TNF/TLR4/NFKBIA/FCGR2A/PIK3R2/BAIAP2/PTK2/RPS6KA1/FOS/CD4/ARHGEF12/PIK3R1/ROCK2/LIMK1/DOCK1	1.45784079715489
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1002	52/9376	1.61953017042837	PLTP/ANGPTL4/SCARB1/ABCA1/APOC2/LRP1/MYLIP/LIPG/CIDEB	1.54958720223505
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1002	17/9376	2.20171421862158	NRP2/CD209/LAMP1/TFRC	1.71539427963389
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1002	83/9376	1.46559892263665	CCL4/GSDMD/NFKBIA/IRF7/NFKBIB/ZDHHC11B/CGAS/IFI16/RIPK3/G3BP1/POLR3D/ADAR/POLR2F	1.47375762477492
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1002	60/9376	1.55954757152362	PLCG2/HSPB1/PIK3R3/NFATC2/SHC2/PIK3R2/PTK2/PRKCA/HRAS/PIK3R1	1.5040106833311
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1002	60/9376	1.55954757152362	IGF1/ITPR2/GNAS/RYR1/PRKCA/PPP2CB/HRAS/PLCB3/GNA11/PPP2CA	1.5040106833311
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/1002	99/9376	1.41777051956693	JUN/PIK3R3/PDGFB/PIK3R2/PDGFC/FOS/PRKCA/CHKB/EGFR/HRAS/DGKZ/GRB2/PIK3R1/LYPLA1/DGKH	1.44545518044668
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/1002	115/9376	1.3832508895253	GNG12/PIK3R3/GNG10/ITPR2/PIK3R2/FOS/PRKACA/PRKCA/HRAS/ADCY6/ATF4/CREB3/PIK3R1/PLCB3/GNA11/KCNJ2/ADCY7	1.43039561566476
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	39/1002	298/9376	1.22461118032392	CSF1R/CCL3/CCL4/CSH1/IL12RB2/CCL2/TNF/IL2RA/IL34/TNFRSF25/BMP2/TNFSF9/CCR1/TNFRSF14/EDA/TNFRSF21/CCL13/TNFRSF1A/CCL8/CD4/EPOR/TNFRSF10D/CXCL1/CCL14/TNFSF18/GDF15/EBI3/TGFB2/CCL18/BMPR1A/IL27RA/IFNGR2/GDF11/ACKR3/INHA/TNFRSF10B/IL4R/TNFRSF4/CSF2RB	1.36300495163773
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	60/1002	480/9376	1.16966067864271	MT-CO3/MT-ATP6/MT-ND1/DKK2/MT-CO1/MT-ND5/TUBA1B/MT-CYB/SQSTM1/MT-ND4/GRIA4/RYR3/TUBB/MT-ND2/FUS/TNF/SLC25A4/WNT5B/ITPR2/NDUFS1/GRIN2C/TNFRSF1A/NDUFS3/MT-CO2/XBP1/NDUFA7/CALML4/MT-ND6/RYR1/NDUFA3/NDUFA6/TUBB2A/CALM3/CSNK1E/PRKCA/PSMC4/FZD3/MT-ND4L/DAXX/COX4I2/SMCR8/PSMA2/GPX3/VCP/FZD9/PSEN2/HRAS/ATP2A2/ATF4/FZD5/PSMA6/UBA7/DCTN4/PSMC3/MAP1LC3A/PLCB3/FZD7/WNT9B/WDR41/HTT	1.31994991416421
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1002	69/9376	1.49174115537042	PLCG2/PIK3R3/ALOX5/TNF/INPP5D/PIK3R2/PRKCA/ALOX5AP/HRAS/GRB2/PIK3R1	1.41810786731364
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1002	69/9376	1.49174115537042	CTSB/ITPR2/GNAS/CALML4/PRKACA/CALM3/ADRB3/ADCY6/PDE1B/PLCB3/KCNJ2	1.41810786731364
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/1002	174/9376	1.29066005919196	RRBP1/HSP90AA1/CANX/HSPH1/MAN1C1/WFS1/PPP1R15A/HSP90AB1/MAN1A1/DNAJB1/HYOU1/XBP1/TXNDC5/ATF6B/HSP90B1/SKP1/RNF5/VCP/P4HB/ATF4/BCAP29/DNAJB2/DNAJB11/HSPA8	1.33866493623096
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/1002	166/9376	1.29649135464012	ATP1B1/NFATC2/SLC25A4/ITPR2/GTF2I/ATP2B4/CALML4/MEF2C/ATF6B/CALM3/MYLK/ADRB3/ATP2A2/CNGA1/ADCY6/ATF4/CREB3/ROCK2/PLCB3/GNA11/ADCY7/ADORA3/IRAG1	1.33318151669853
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1002	54/9376	1.55954757152362	HLA-E/HLA-A/HLA-G/CD28/HLA-F/HLA-B/HLA-DRB1/HLA-DRB3/HLA-DQB2	1.42637056000853
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1002	93/9376	1.40862361298908	RYR3/ATP1B1/ITPR2/GNAS/ATP2B4/CALML4/PRKACA/CALM3/PRH1/PRKCA/ADRB3/ADCY6/PLCB3/ADCY7	1.36985241334058
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/1002	158/9376	1.30291316101973	CCND1/CDKN1C/YWHAE/CDC14B/CDKN2A/CDKN2B/ATRX/MAD1L1/SKP1/PPP2CB/ATM/CCNE1/DDX11/TGFB2/CDKN2C/CDK7/SKP2/HDAC8/ORC6/RB1/CDK4/PPP2CA	1.32825468160107
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	21/1002	150/9376	1.31001996007984	CCND1/PIK3R3/SHC2/WNT5B/PIK3R2/CDKN2B/FZD3/EGFR/FZD9/CCNE1/TGFB2/HRAS/RXRB/GRB2/FZD5/PIK3R1/FZD7/WNT9B/CDH1/DDB2/RB1	1.32398047671162
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/1002	200/9376	1.26323353293413	JUN/CYFIP1/TUBA1B/TUBB/NAIP/TNF/NCK2/TLR4/NFKBIA/FCGR2A/CYTH4/TNFRSF1A/BAIAP2/FOS/NFKBIB/TUBB2A/CLDN7/CLDN23/MYO5A/ARHGEF12/OCLN/MYO1C/ROCK2/NCL/TJP1/CLDN19/TNFRSF10B	1.30161495158793
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1002	32/9376	1.75449101796407	GALE/GAA/GALT/UGP2/PGM1/PFKL	1.47882120358925
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1002	62/9376	1.50923958534544	IGF1/PIK3R3/PIK3R2/PRKACA/PRKAG1/HRAS/ADCY6/PIK3R1/HSPA8/ADCY7	1.39156310132083
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1002	70/9376	1.47043056743656	TNF/NFKBIA/PCK2/TNFRSF1A/POMC/NFKBIB/SLC2A1/PRKAG1/STAT3/RXRB/NFKBIE	1.36652018154344
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1002	47/9376	1.59272943474753	LDHA/PCK2/ACSS1/PDHB/ME1/GLO1/ACACA/ADH5	1.40909702443699
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1002	78/9376	1.43958237371411	BTG2/TOB2/HSPD1/PARN/LSM2/CNOT3/DHX36/HSPA9/PFKL/ENO2/NUDT16/DCP1B	1.34848407178166
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1002	78/9376	1.43958237371411	FN1/CLTC/DNM1/PIK3R3/SHC2/PIK3R2/CLTA/PTK2/PIK3R1/SEPTIN8/CDH1/DOCK1	1.34848407178166
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	13/1002	86/9376	1.41447337882375	ATP1B1/GNAS/ATF6B/PRKACA/PRKCA/SLC2A1/ADCY6/ATF4/CREB3/PLCB3/GNA11/TRPM4/ADCY7	1.33564496349899
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1002	63/9376	1.48528340145107	WNT5B/BMP2/FZD3/FZD9/GLI3/SMO/FZD5/FZD7/WNT9B/DDB2	1.33682306772067
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1002	71/9376	1.44972027775435	CCND1/PIK3R3/SHC2/PIK3R2/FOS/STAT3/HRAS/IRF1/GALT/GRB2/PIK3R1	1.31572908921235
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1002	144/9376	1.29962297626968	CD14/C2/C1QA/CCND1/C1QC/C1QB/TNF/TRA2B/TLR4/NFKBIA/TNFRSF1A/C3AR1/CXCL1/SREBF1/PRKAG1/TRA2A/SCD/ACADVL/ACACA/ADH5	1.25331859318181
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1002	87/9376	1.39821506412462	JUN/CCND1/PIK3R3/PIK3R2/FOS/PMAIP1/EGFR/TGFB2/HRAS/TGFA/GRB2/PIK3R1/DDB2	1.29076104665946
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1002	33/9376	1.70132462348031	IDH1/BCAT1/ACY1/PDHB/CS/BCKDHB	1.39600155945437
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	24/1002	178/9376	1.26165646235619	JUN/NOTUM/DKK2/ROR1/CCND1/NFATC2/PRICKLE2/LZTS2/WNT5B/MCC/PRKACA/CSNK1E/PRKCA/SFRP1/FZD3/SKP1/FZD9/FZD5/ROCK2/PLCB3/TLE4/FZD7/WNT9B/DAAM1	1.21912372936164
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1002	19/9376	1.96995482718773	HEXA/HEXB/HYAL2/NAGLU	1.46390540798381
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/1002	112/9376	1.33675506130596	ALOX5/TNF/BIRC7/TLR4/NFKBIA/HLA-DRB1/TNFRSF1A/NFKBIB/LAMA3/LAMB2/STAT3/TGFB2/IFNGR2/HLA-DRB3/HSPA8/HLA-DQB2	1.24015763278416
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1002	49/9376	1.52772007006395	JUN/FOSB/GRIN2C/GNAS/ATF6B/PRKACA/ATF4/CREB3	1.28110192493685
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1002	105/9376	1.33675506130596	PLCG2/CD14/CCL4/TNF/TLR4/NFKBIA/EDA/CCL13/TNFRSF1A/PARP1/CXCL1/NFKB2/ATM/TICAM2/BLNK	1.20032405993711
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/1002	105/9376	1.33675506130596	LMNA/IGF1/TPM1/ITGB5/TNF/GNAS/CACNB4/PRKACA/ITGA9/TGFB2/ATP2A2/ADCY6/DMD/ADCY7/TTN	1.20032405993711
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1002	65/9376	1.43958237371411	SPP1/PIK3R3/KCNJ5/ITPR2/PIK3R2/PRKCA/HRAS/PIK3R1/PLCB3/GNA11	1.23013225317104
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1002	122/9376	1.30388403520827	IGF1/CCND1/PIK3R3/EEF2K/PCK2/PIK3R2/PPP2CB/SREBF1/PRKAG1/SCD/CREB3/PPP2R3B/PIK3R1/PFKL/ACACA/PPP2CA/PFKFB2	1.16862742264839
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1002	42/9376	1.55954757152362	FTL/SLC40A1/NCOA4/HMOX1/TFRC/MAP1LC3A/STEAP3	1.25713171467007
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/1002	50/9376	1.49716566866267	AOC1/LAP3/CNDP2/GATM/P4HA1/GAMT/SMOX/P4HA2	1.21924630603591
Human Diseases	Substance dependence	hsa05032	Morphine addiction	13/1002	91/9376	1.33675506130596	GNG12/PDE4C/GABRA3/GNG10/GABRB2/KCNJ5/GNAS/PRKACA/PRKCA/ADCY6/PDE1B/ADCY7/GRK3	1.11659812576642
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1002	51/9376	1.46780947908105	PLCG2/GNAS/PRKACA/PRKCA/ATP6V0A1/TJP1/ATP6AP1/ATP6V0E2	1.15873121360411
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/1002	235/9376	1.19454707606064	MT-CO3/MT-ATP6/MT-ND1/FGFR1/MT-CO1/MT-ND5/MT-CYB/MT-ND4/MT-ND2/NDUFS1/NDUFS3/GNAS/MT-CO2/NDUFA7/MT-ND6/NDUFA3/NDUFA6/RPS6KA1/PRKACA/MT-ND4L/COX4I2/SMARCB1/ADRB3/PRKAG1/KDM3A/HRAS/ADCY6/CREB3/GRB2/ADCY7	1.04475583488577
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1002	75/9376	1.37240186294079	PIK3R3/PIK3R2/CDKN2A/PMAIP1/ATM/TOP2A/PIK3R1/GSTA4/XPA/GSTM3/BRCA1	1.12003262968912
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1002	59/9376	1.42738252308941	CCND1/PIK3R3/PIK3R2/EGFR/HRAS/GRB2/PIK3R1/CDH1/DDB2	1.13908920832655
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/1002	67/9376	1.39660976554354	ITPR2/GRIN2C/CALML4/RPS6KA1/PRKACA/CALM3/PRKCA/HRAS/ATF4/PLCB3	1.12694393425793
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/1002	133/9376	1.26639953176354	HLA-E/PLCG2/HLA-A/HLA-G/PIK3R3/NFATC2/TNF/SHC2/ITGB2/HLA-B/PIK3R2/PRKCA/ULBP2/HRAS/IFNGR2/GRB2/PIK3R1/TNFRSF10B	1.07030073043788
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/1002	100/9376	1.31001996007984	CSF1R/CD14/TNF/IL2RA/CR1/CD59/HLA-DRB1/ITGAM/CD4/EPOR/TFRC/HLA-DRB3/HLA-DQB2/IL4R	1.07810809437734
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1002	21/9376	1.78234008174128	CSGALNACT1/CHSY1/CHSY3/B4GALT7	1.24147035415094
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	7/1002	44/9376	1.48865904554527	GTF2I/GTF2H2/GTF2H1/TAF15/CDK7/GTF2H3/GTF2F1	1.12382305226601
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1002	44/9376	1.48865904554527	POLE/PARP1/POLG2/POLD4/POLD3/POLD1/TDP1	1.12382305226601
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1002	52/9376	1.43958237371411	IGF1/ALOX5/SCARB1/GNAS/CYP11A1/PRKACA/ADCY6/ADCY7	1.09949644609639
Organismal Systems	Immune system	hsa04611	Platelet activation	17/1002	126/9376	1.26249089123341	PLCG2/PIK3R3/COL1A2/FCGR2A/ITPR2/PIK3R2/GNAS/TLN1/PRKACA/MYLK/P2RY1/ARHGEF12/ADCY6/PIK3R1/ROCK2/PLCB3/ADCY7	1.02608104366808
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/1002	169/9376	1.21810816237348	CTSB/CTSL/SQSTM1/CTSD/PIK3R3/PIK3R2/LAMP1/PRKACA/STX7/SMCR8/PPP2CB/VPS11/HRAS/ATG9A/VPS16/WDFY3/PIK3R1/ATG16L1/MAP1LC3A/WDR41/PPP2CA/PLEKHM1	0.989712875375298
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1002	29/9376	1.61332507398995	RASSF4/CSNK1E/DCHS1/LIMD1/SAV1	1.14421231628452
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	38/1002	308/9376	1.15447028021878	MT-CO3/MT-ATP6/MT-ND1/CLTC/MT-CO1/MT-ND5/TUBA1B/MT-CYB/MT-ND4/GRIA4/AP2A2/TUBB/MT-ND2/POLR2J3/SLC25A4/POLR2A/NDUFS1/NDUFS3/MT-CO2/NDUFA7/MT-ND6/CLTA/NDUFA3/NDUFA6/TUBB2A/PSMC4/AP2M1/MT-ND4L/COX4I2/PSMA2/GPX3/CREB3/POLR2F/PSMA6/DCTN4/PSMC3/PLCB3/HTT	0.953493106577803
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1002	37/9376	1.51739763715812	HBA2/HBA1/TNF/APOL1/PRKCA/PLCB3	1.09075731971699
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1002	37/9376	1.51739763715812	CCND1/NCOA4/HRAS/RXRB/CDH1/DDB2	1.09075731971699
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1002	128/9376	1.24276447105788	PDE4C/AK1/NME2/NME4/AK6/PDE9A/IMPDH2/ADCY6/PDE1B/HDDC3/NME1/ATIC/AK3/PGM1/ADCY7/ENPP4/NUDT16	0.956575431587632
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1002	154/9376	1.21523187391451	TPM1/ATP1B1/SCN1B/GNAS/ATP2B4/CACNB4/CALML4/ATF6B/PRKACA/CALM3/PRKCA/PPP2CB/ATP2A2/ADCY6/ATF4/CREB3/PPP2R3B/PLCB3/ADCY7/PPP2CA	0.931552657357212
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1002	62/9376	1.35831562681089	RBPJ/DLL1/DTX2/DTX1/KAT2A/PSEN2/DTX3L/TLE4/MAML1	0.979143843576989
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1002	38/9376	1.4774661203908	IGF1/PIK3R3/ATP1B1/PIK3R2/PRKCA/PIK3R1	1.02014156961987
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1002	23/9376	1.62735398767682	LARGE1/POMT1/B3GALNT2/B4GAT1	1.04196740711922
NA	NA	hsa04519	Cadherin signaling	48/1002	404/9376	1.1117566846505	CYFIP1/FGFR1/PCDH12/ENAH/KRT7/YWHAE/MYO7A/GABRA3/PRICKLE2/AFDN/GABRB2/KRT19/SCN1B/NFKBIA/WNT5B/FMN1/DSC2/KRT8/ACTN4/KRT18/PTK2/CTNND1/TMC6/FZD3/DCHS1/LIMD1/EGFR/ATN1/FZD9/PCDH18/TMIE/LHFPL2/PALS1/PSEN2/HRAS/SAV1/DSP/FZD5/MYO1C/ROCK2/RERE/LIMA1/TJP1/FZD7/WNT9B/CDH1/DAAM1/TAOK2	0.794278085628726
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1002	89/9376	1.26165646235619	GNG12/GABRA3/GNG10/GABRB2/PRKACA/PRKCA/GAD1/SLC12A5/NSF/SLC38A2/ADCY6/ADCY7	0.85791007209707
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1002	16/9376	1.75449101796407	HEXA/HEXB/GBGT1	1.04479037151332
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	20/1002	158/9376	1.18446651001794	IGF1/PIK3R3/TNF/WNT5B/PIK3R2/PRR5/TNFRSF1A/RPS6KA1/PRKCA/FZD3/EIF4E/FZD9/HRAS/SKP2/FLCN/GRB2/FZD5/PIK3R1/FZD7/WNT9B	0.808873753471466
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/1002	98/9376	1.24127255692696	PLCG2/SCIN/PIK3R3/ASAP2/FCGR2A/INPP5D/PIK3R2/PRKCA/BIN1/ASAP3/PIK3R1/LIMK1/DOCK1	0.830513700574079
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1002	56/9376	1.33675506130596	CCND1/DHH/PRKACA/CSNK1E/GLI3/MEGF8/SMO/GRK3	0.874285367253968
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1002	24/9376	1.55954757152362	HS6ST1/HS2ST1/NDST2/B4GALT7	0.949387277778787
Human Diseases	Immune disease	hsa05310	Asthma	5/1002	32/9376	1.46207584830339	PRG2/TNF/HLA-DRB1/HLA-DRB3/HLA-DQB2	0.905680181563257
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/1002	168/9376	1.16966067864271	SQSTM1/HSP90AA1/PYGL/TNF/FTL/SLC25A4/HSP90AB1/TLR4/CHMP4A/IRF9/TNFRSF1A/PARP1/PYGM/RNF31/RIPK3/STAT3/SHARPIN/IFNGR2/TICAM2/CHMP6/TNFRSF10B	0.767549169450955
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/1002	232/9376	1.12932755179297	FN1/CYFIP1/FGFR1/SCIN/ENAH/GNG12/ITGB5/PIK3R3/C9/PDGFB/ITGB2/PIK3R2/PDGFC/ACTN4/BAIAP2/PTK2/ITGAM/PIP4K2B/MYLK/EGFR/ARHGEF12/ITGA9/HRAS/PIK3R1/ROCK2/LIMK1/DOCK1/PAK6	0.689953720340964
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	28/1002	233/9376	1.12448065242905	FN1/LMNA/TPM1/ITGB5/ATP1B1/COL1A2/COL4A1/DSC2/INF2/FBLN1/HSPG2/TLN1/COL27A1/ZYX/CAPZB/SUN1/ITGA9/AGRN/SPTBN5/FBN1/DSP/ANK2/DMD/SPTAN1/SDC3/DAAM1/ENO2/TTN	0.665561937286757
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	43/1002	368/9376	1.09337846047036	MT-CO3/MT-ATP6/MT-ND1/MT-CO1/HNRNPA2B1/MT-ND5/TUBA1B/MT-CYB/SQSTM1/MT-ND4/CHCHD10/TUBB/MT-ND2/SRSF7/FUS/TNF/SRSF3/NDUFS1/GRIN2C/TNFRSF1A/NDUFS3/MT-CO2/XBP1/NDUFA7/MT-ND6/NDUFA3/NDUFA6/TUBB2A/PSMC4/MT-ND4L/DAXX/COX4I2/SMCR8/PSMA2/GPX3/VCP/ATF4/PSMA6/DCTN4/PSMC3/MAP1LC3A/NUP160/WDR41	0.632134437783053
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/1002	93/9376	1.20739166827635	FGFR1/AFDN/ACTN4/BAIAP2/PTPRF/CTNND1/EGFR/HEG1/ROCK2/TJP1/CDH1/PTPRM	0.695251004260205
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1002	10/9376	1.87145708582834	SELENBP1/TST	0.953722326383761
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1002	59/9376	1.26878446496837	PIK3R3/PIK3R2/GNAS/PRKACA/ADRB3/ADCY6/PIK3R1/ADCY7	0.71638278794858
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1002	34/9376	1.37607138663849	POLR2J3/POLR2A/POLR1A/POLR3D/POLR2F	0.759876194608442
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1002	18/9376	1.55954757152362	ABCD4/CD320/TCN2	0.821929878444873
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1002	35/9376	1.33675506130596	HSD17B14/TIGAR/ENOSF1/PFKL/PFKFB2	0.690405891229428
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/1002	104/9376	1.16966067864271	PLD3/PLA2G15/CDS1/PTDSS2/CHKB/DGKZ/ETNK1/AGPAT1/PLB1/AGPAT2/LYPLA1/DGKH/MBOAT1	0.601816622068742
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1002	61/9376	1.22718497431367	ATP1B1/FTL/SLC40A1/HMOX1/ATP2B4/HMOX2/SLC46A1/CLCN2	0.615752399580926
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1002	44/9376	1.27599346761023	MAN1C1/HEXA/MAN1A1/MGAT4B/HEXB/ALG3	0.63473258911868
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1002	19/9376	1.4774661203908	PDHB/LIAS/BCKDHB	0.720616276322582
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	10/1002	79/9376	1.18446651001794	CLTC/AP2A2/DNM1/CLTA/AP2M1/SYT1/NSF/ATP6V0A1/SLC6A2/ATP6V0E2	0.569524854978489
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1002	36/9376	1.29962297626968	PYGL/PYGM/GAA/UGP2/PGM1	0.623025678285683
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/1002	195/9376	1.10367981984748	PLCG2/PIK3R3/CR1/GSDMD/SLC25A4/TLR4/NCF4/TLR7/ITGB2/FCGR2A/PIK3R2/H3-7/H3C12/ITGAM/PRKCA/AZU1/H2BC5/CLCN5/HDAC8/PIK3R1/H2BC15/PLCB3/H2BC11	0.506080456800754
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1002	54/9376	1.21298144451837	LDHA/MAT2A/BCAT1/ADI1/AHCY/TST/DNMT3A	0.542921599073137
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/1002	143/9376	1.11240456150636	C2/C1QA/CD28/C1QC/C1QB/TNF/C9/FCGR2A/HLA-DRB1/H3-7/ACTN4/H3C12/H2BC5/HLA-DRB3/H2BC15/HLA-DQB2/H2BC11	0.468525850177322
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1002	37/9376	1.2644980309651	GALE/GALT/UGP2/PGM1/NAGK	0.557604330994931
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1002	72/9376	1.16966067864271	TNF/NFKBIA/IRF7/NFKBIB/IFIH1/ISG15/ADAR/DDX3X/TBKBP1	0.499879835105087
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1002	99/9376	1.13421641565354	LMNA/IGF1/TPM1/ITGB5/TNF/CACNB4/PRKAG1/ITGA9/TGFB2/ATP2A2/DMD/TTN	0.464378897554826
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	17/1002	144/9376	1.10467952982923	RBPJ/PIK3R3/SLC25A4/ITPR2/PIK3R2/GRIN2C/XBP1/RYR1/PRKCA/PSMC4/PSMA2/ATP2A2/PIK3R1/PSMA6/PSMC3/PLCB3/NOP56	0.437872965197494
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1002	55/9376	1.19092723643622	NEU1/HEXA/SGPP1/SPTLC3/HEXB/PSAP/UGCG	0.491214296142203
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/1002	83/9376	1.12738378664358	IDH1/HSD17B4/ECH1/PHYH/DECR2/ABCD4/PXMP2/PMVK/PIPOX/CRAT	0.403207176201268
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1002	30/9376	1.2476380572189	IDH1/PCK2/PDHB/CS	0.469913744532414
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1002	48/9376	1.16966067864271	PIK3R3/ATP1B1/PIK3R2/SLC37A4/PIK3R1/PLCB3	0.407624773519162
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1002	75/9376	1.12287425149701	SHMT1/IDH1/MAT2A/BCAT1/ACY1/CS/ASL/PFKL/ENO2	0.369555538574621
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/1002	94/9376	1.09500148638892	JUN/FOSB/HSP90AA1/CCL2/TNF/HSP90AB1/NFKBIA/SRSF1/FOS/HSP90B1/CXCL1	0.320203862051979
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1002	67/9376	1.11728781243483	LDHA/PCK2/ACSS1/PDHB/PGM1/PFKL/ENO2/ADH5	0.333266601755687
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/1002	168/9376	1.05826442353388	CSH1/CCND1/IL12RB2/PIK3R3/IL2RA/PDGFB/PIK3R2/IRF9/EPOR/EGFR/PIAS2/STAT3/HRAS/IL27RA/IFNGR2/GRB2/PIK3R1/IL4R/CSF2RB	0.263589714775034
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1002	59/9376	1.11018640684732	HPGDS/LAP3/IDH1/GPX3/TXNDC12/GSTA4/GSTM3	0.293676367570614
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1002	32/9376	1.16966067864271	LDHA/ACSS1/ACACA/BCKDHB	0.332539159537265
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1002	32/9376	1.16966067864271	PPP2CB/ATG9A/ATG16L1/PPP2CA	0.332539159537265
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1002	32/9376	1.16966067864271	BIRC7/TNFRSF1A/SEPTIN4/PMAIP1	0.332539159537265
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1002	23/9376	1.22051549075762	IDI1/PMVK/FDPS	0.366252480493834
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1002	23/9376	1.22051549075762	POLD4/POLD3/POLD1	0.366252480493834
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1002	87/9376	1.07555004932663	MT-CO3/MT-CO1/MT-CYB/TPM1/ATP1B1/MT-CO2/CACNB4/TRDN/COX4I2/ATP2A2	0.244885413760995
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1002	78/9376	1.07968678028558	PLCG2/PLCH1/INPP5D/PI4K2A/PIP4K2B/INPP4B/ITPK1/PLCB3/ISYNA1	0.244451007074636
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/1002	226/9376	1.03509794570152	JUN/GRIA4/PIK3R3/PDE4C/ATP1B1/AFDN/NFKBIA/PIK3R2/GRIN2C/GNAS/ATP2B4/CALML4/POMC/FOS/PRKACA/CALM3/GLI3/ATP2A2/CNGA1/ADCY6/SSTR2/CREB3/PIK3R1/ROCK2/ADCY7	0.184747423746086
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/1002	134/9376	1.04745732415765	ITPR2/ADM/GNAS/CALML4/PRKACA/CALM3/PRKCA/MYLK/ARHGEF12/ADCY6/ROCK2/PLCB3/GNA11/ADCY7/IRAG1	0.191392839211113
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1002	116/9376	1.04866129809347	GRIA4/GNG12/GNG10/ITPR2/GRIN2C/GNAS/PRKACA/PRKCA/SLC38A2/ADCY6/PLCB3/ADCY7/GRK3	0.182414859064681
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/1002	154/9376	1.03294709282733	SHMT1/CMPK2/MAT2A/AK1/NAPRT/NME2/NME4/BCAT1/AK6/DHRS3/PDXP/NME1/LIAS/UGP2/AK3/UROS/FPGS	0.142599473383237
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1002	89/9376	1.05138038529682	SPP1/FN1/ITGB5/COL1A2/COL4A1/HSPG2/LAMA3/LAMB2/ITGA9/AGRN	0.168464213180285
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1002	90/9376	1.03969838101575	EPHX1/ABCG2/ATP1B1/SCARB1/GNAS/PRKACA/SLC2A1/ABCC3/ADCY6/ADCY7	0.130897915736907
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1002	34/9376	1.10085710931079	CSNK1E/SKP1/PRKAG1/PER3	0.203788214539073
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/1002	138/9376	1.01709624229801	IGF1/YWHAE/ITPR2/CALML4/RPS6KA1/PRKACA/CALM3/MAD1L1/SKP1/PPP2CB/CCNE1/ADCY6/REC8/ADCY7/PPP2CA	0.0699848843407149
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1002	63/9376	1.03969838101575	HPGDS/ALOX5/LTC4S/HPGD/PRXL2B/PTGR2/PLB1	0.109358183969054
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1002	36/9376	1.03969838101575	DHDH/UGP2/XYLB/DCXR	0.0825474436810788
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1002	36/9376	1.03969838101575	POLE/POLD4/POLD3/POLD1	0.0825474436810788
NA	NA	hsa04382	Cornified envelope formation	23/1002	217/9376	0.991786013227002	KRT7/KRT19/S100A13/COL4A1/S100A1/KRT8/KRT18/PRSS8/LAMA3/CLDN7/CLDN23/SPTLC3/PPP2CB/OCLN/DSP/PPP2R3B/ST14/TJP1/CLDN19/COL17A1/PPP2CA/UGCG/TCHH	-0.0423460452518267
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1002	65/9376	1.00770766159988	ABHD16A/DGKZ/AGPAT1/AGPAT2/LIPG/DGKH/MBOAT1	0.021569206814246
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1002	46/9376	1.01709624229801	FTL/BLVRB/HMOX1/HMOX2/UROS	0.0402060843025434
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/1002	46/9376	1.01709624229801	PSMC4/PSMA2/PSMB8/PSMA6/PSMC3	0.0402060843025434
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1002	27/9376	1.03969838101575	GAD1/ACSM5/OXCT1	0.0714537652022966
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1002	27/9376	1.03969838101575	HSD17B4/SCD/HACD2	0.0714537652022966
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/1002	85/9376	0.990771398379711	CMPK2/AK1/NME2/NME4/AK6/IMPDH2/NME1/AK3/NUDT16	-0.029564269483895
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1002	191/9376	0.979820463784473	FOSB/GNG12/GNG10/SHC2/GRIN2C/H3-7/GNAS/H3C12/CALML4/ATF6B/PRKACA/CALM3/H2BC5/HRAS/ATF4/CREB3/HDAC8/GRB2/H2BC15/H2BC11	-0.0974633432291505
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/1002	57/9376	0.984977413593865	HSD17B4/SCD/MECR/ACADVL/ACACA/HACD2	-0.0393505224968588
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1002	115/9376	0.976412392606092	GNG12/ALOX5/GNG10/GABRB2/KCNJ5/HTR2B/ITPR2/GNAS/PRKACA/PRKCA/HRAS/PLCB3	-0.0880353082599705
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1002	18/9376	1.03969838101575	MECR/ACACA	0.0583136933181262
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1002	28/9376	1.00256629597947	SLC12A7/ATP6V0A1/ATP6V0E2	0.00470413122363712
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1002	38/9376	0.984977413593865	NNMT/SIRT2/NAPRT/NMRK1	-0.0320968634665877
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1002	38/9376	0.984977413593865	CD4/TAP1/TAP2/BLNK	-0.0320968634665877
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/1002	117/9376	0.959721582476074	CHD4/INO80D/SMARCA1/TFPT/SMARCB1/SRCAP/MBD3/CECR2/PBRM1/MRGBP/RBBP7/BRD8	-0.151647867994548
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1002	39/9376	0.959721582476074	SHMT1/MAT2A/ATIC/AHCY	-0.0871874637251573
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/1002	49/9376	0.954825043789971	COLGALT1/GALNT1/POMT1/C1GALT1C1/PLOD3	-0.109667466982243
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1002	29/9376	0.967995044393971	CALML4/CALM3/CNGA1	-0.0597080829393222
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1002	30/9376	0.935728542914172	B3GALT4/PIGW/PIGQ	-0.121960418382136
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1002	110/9376	0.935728542914172	IGF1/HSP90AA1/PIK3R3/HSP90AB1/PIK3R2/RPS6KA1/PRKACA/MAD1L1/ADCY6/PIK3R1/ADCY7	-0.234542398013669
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1002	20/9376	0.935728542914172	NPL/UGP2	-0.0995270330615698
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1002	41/9376	0.912905895526021	GATM/SHMT1/GAMT/PIPOX	-0.193319892908716
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1002	41/9376	0.912905895526021	GRIA4/GABRA3/GABRB2/GRIN2C	-0.193319892908716
NA	NA	hsa04081	Hormone signaling	22/1002	219/9376	0.940001275986839	IGF1/CSH1/GNG12/PIK3R3/GNG10/SLC40A1/DIO2/PIK3R2/GNAS/POMC/PRKACA/EPOR/ADRB3/STAT3/BMPR1A/ADCY6/SSTR2/HAMP/PIK3R1/PLCB3/GNA11/ADCY7	-0.310771000095854
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1002	31/9376	0.905543751207263	CNDP2/GAD1/SMOX	-0.182211133120727
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1002	31/9376	0.905543751207263	SHMT1/ACSS1/CS	-0.182211133120727
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/1002	142/9376	0.922549267661859	WWP1/BIRC7/HERC2/SKP1/TRIM32/PML/PIAS2/HERC3/KLHL9/SKP2/UBA7/RHOBTB2/DDB2/BRCA1	-0.321682760049814
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1002	43/9376	0.870445156199229	SCARB1/ABCA1/AGPAT1/AGPAT2	-0.294530497249663
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1002	22/9376	0.850662311740156	AOC1/CNDP2	-0.242568890911186
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/1002	86/9376	0.870445156199229	SCN9A/GABRA3/PRKACA/P2RY1/ADCY6/PDE1B/PKD1L3/PLCB3	-0.417491890819316
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/1002	86/9376	0.870445156199229	LMNA/ITGB5/DSC2/CACNB4/ITGA9/ATP2A2/DSP/DMD	-0.417491890819316
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1002	23/9376	0.81367699383841	ACY1/ASL	-0.309462446131547
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1002	23/9376	0.81367699383841	ATP1B1/PCK2	-0.309462446131547
NA	NA	hsa04082	Neuroactive ligand signaling	19/1002	199/9376	0.893409161576345	GRIA4/GNG12/GABRA3/GNG10/GABRB2/HTR2B/GRIN2C/HRH1/GNAS/POMC/PRKACA/PRKCA/P2RY1/ADCY6/PLCB3/GNA11/ADCY7/ADORA3/SLC6A2	-0.525713429506583
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1002	12/9376	0.77977378576181	CD209	-0.264047435821329
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1002	79/9376	0.829126557012557	HPGDS/EPHX1/AKR7A2/DHDH/GSTA4/ADH5/GSTM3	-0.527557402303728
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1002	47/9376	0.796364717373763	PIK3R3/TNF/PIK3R2/PIK3R1	-0.484102617480501
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1002	13/9376	0.719791186857055	RAD50	-0.349702692209555
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1002	37/9376	0.758698818579058	RIMKLB/GAD1/ASL	-0.508701646449179
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1002	102/9376	0.825642831983093	ATP1B1/ITPR2/GNAS/ATP2B4/PRKCA/ATP2A2/ADCY6/PLCB3/ADCY7	-0.612434104533681
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/1002	103/9376	0.817626882158014	DDX39B/FUS/PCF11/CPSF1/PPP2CB/PNN/PPP2R3B/UPF1/PPP2CA	-0.64375753592024
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1002	14/9376	0.66837753065298	B3GNT2	-0.429513351973574
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1002	50/9376	0.748582834331337	CD28/HLA-DRB1/HLA-DRB3/HLA-DQB2	-0.61657405134207
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/1002	83/9376	0.789168650650506	PHF1/CBX4/SKP1/RING1/SCML2/EPOP/RBBP7	-0.667343272372383
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/1002	105/9376	0.802053036783576	JUN/SQSTM1/CITED2/VCP/HRAS/ATG9A/ATF4/RAB5C/MAP1LC3A	-0.705558816603167
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1002	51/9376	0.733904739540527	ENPP2/PLD3/PLB1/TMEM86A	-0.659099265564655
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1002	15/9376	0.623819028609448	AK1	-0.50435270120759
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/1002	28/9376	0.66837753065298	MECR/HACD2	-0.607878290343316
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1002	28/9376	0.66837753065298	GCNT2/B3GNT2	-0.607878290343316
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1002	28/9376	0.66837753065298	QDPR/FPGS	-0.607878290343316
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	30/1002	323/9376	0.86909771787694	PLCG2/FSCN1/CCND1/TIMP3/TPM1/PIK3R3/PDGFB/ABCC1/PIK3R2/EFNA2/HMOX1/CDKN2A/PRKCA/FZD3/EGFR/ATM/CCNE1/STAT3/MMP16/TGFB2/HRAS/GRB2/PIK3R1/STMN1/ST14/SPRY2/EFNA4/BRCA1/BMF/DNMT3A	-0.828142817723613
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/1002	76/9376	0.738733060195399	PLTP/ANGPTL4/PCK2/SCD/RXRB/ME1	-0.791047934700737
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1002	16/9376	0.584830339321357	MIF	-0.574911103901511
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1002	54/9376	0.693132254010497	TOP3A/CENPX/RAD51C/BRCA1	-0.782251842329952
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/1002	43/9376	0.652833867149422	GCDH/ACADVL/ADH5	-0.78924886740603
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1002	17/9376	0.550428554655395	HSD17B4	-0.641743497481012
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1002	17/9376	0.550428554655395	GAD1	-0.641743497481012
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1002	17/9376	0.550428554655395	SEPHS1	-0.641743497481012
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1002	17/9376	0.550428554655395	CA8	-0.641743497481012
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1002	31/9376	0.603695834138175	PGM1/PFKL	-0.764491836644904
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/1002	56/9376	0.66837753065298	MAN1C1/MAN1A1/MGAT4B/ALG3	-0.860960103400817
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1002	103/9376	0.726779450807123	SLC7A8/ATP1B1/COL1A2/COL4A1/COL27A1/SLC38A2/SLC36A1/COL17A1	-0.964439219948939
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/1002	82/9376	0.684679421644516	NME2/NME4/IMPDH2/NME1/GSTA4/GSTM3	-0.991998298575476
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/1002	116/9376	0.725996283295478	SHMT1/IDH1/ACSS1/PDHB/CS/ME1/PFKL/ENO2/ADH5	-1.02714788392715
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/1002	59/9376	0.634392232484184	CMPK2/NME2/NME4/NME1	-0.974442893563286
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/1002	194/9376	0.771734880753956	TUBA1B/TPM1/TUBB/MYO7A/DYNLRB1/KIF26A/TUBB2A/MYO18B/KIFC3/MYO5A/CAPZB/KIF16B/MYO19/MYO1C/DCTN4/DYNC2H1	-1.11128331620078
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1002	20/9376	0.467864271457086	MSMO1	-0.824034379323433
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/1002	48/9376	0.584830339321357	BCAT1/OXCT1/BCKDHB	-0.997481798729243
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1002	21/9376	0.44558502043532	BCAT1	-0.879783328363798
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1002	36/9376	0.519849190507873	GALNT1/C1GALT1C1	-0.99840902552813
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1002	37/9376	0.505799212386039	MIF/ADH5	-1.04185463517123
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1002	68/9376	0.550428554655395	RDH10/ALDH1A1/DHRS3/ADH5	-1.28699840547408
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/1002	243/9376	0.731639601455525	HNRNPU/DDX39B/SRSF7/FUS/PRPF8/TRA2B/SRSF3/CWC25/SRSF1/DHX16/PRPF31/SRSF2/PUF60/LSM2/TRA2A/SRSF6/RBM25/HSPA8/PPIL1	-1.46611439150952
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1002	26/9376	0.359895593428528	PLB1	-1.13053680676253
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1002	26/9376	0.359895593428528	HHEX	-1.13053680676253
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1002	42/9376	0.44558502043532	AOC1/GCDH	-1.2456003553033
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1002	70/9376	0.534702024522384	HPGDS/EPHX1/GSTA4/GSTM3	-1.35161088146598
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1002	73/9376	0.512727968720094	HPGDS/GSTA4/ADH5/GSTM3	-1.44568749511002
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1002	30/9376	0.311909514304724	PLB1	-1.30570874421124
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1002	31/9376	0.301847917069088	HSD17B14	-1.34677254016908
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/1002	31/9376	0.301847917069088	BAG6	-1.34677254016908
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/1002	33/9376	0.283554103913385	STX7	-1.42610077375912
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/1002	108/9376	0.346566127005249	DDX39B/PNN/NUP160/UPF1	-2.36250931612164
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/1002	183/9376	0.409061658104556	RMRP/RPP25/AK6/DKC1/POP7/RPP38/BMS1/NOP56	-2.79249307468412
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1002	66/9376	0.141777051956693	CYP11A1	-2.42019450712994
Genetic Information Processing	Translation	hsa03010	Ribosome	8/1002	222/9376	0.337199474924026	RPS4Y1/RPS9/MRPS18B/MRPL38/MRPL22/MRPS12/MRPL14/MRPL27	-3.45705984506244
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/1002	370/9376	0.455219291147435	CSH1/GRIA4/GABRA3/GABRB2/HTR2B/LPAR6/ADM/GRIN2C/HRH1/POMC/S1PR1/C3AR1/P2RY1/ADRB3/SSTR2/PTAFR/ADORA3/S1PR2	-3.6983638197644
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1002	449/9376	0.104201396761044	CALML4/PRKACA/CALM3/PDE1B/GRK3	-6.72874088858758