ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 94/1983 489/18639 0.192229038854806 1.8068366390392 8.00032664520374e-09 5.66720416596841e-06 GO:0060589 nucleoside-triphosphatase regulator activity 94/1983 490/18639 0.191836734693878 1.80314921732687 8.88973202504848e-09 5.66720416596841e-06 GO:0005096 GTPase activator activity 57/1983 271/18639 0.210332103321033 1.97699449006593 3.47838152111488e-07 0.000147831214647382 GO:0031418 L-ascorbic acid binding 11/1983 20/18639 0.55 5.1696671709531 1.29586540098656e-06 0.000413057096564465 GO:0140597 protein carrier chaperone 41/1983 188/18639 0.218085106382979 2.04986802716709 5.81553454425006e-06 0.00137319721027437 GO:0140713 histone chaperone activity 37/1983 164/18639 0.225609756097561 2.12059518098963 7.21455385004811e-06 0.00137319721027437 GO:0140658 ATP-dependent chromatin remodeler activity 36/1983 158/18639 0.227848101265823 2.14163427105077 7.53912193876126e-06 0.00137319721027437 GO:0000510 H3-H4 histone complex chaperone activity 34/1983 151/18639 0.225165562913907 2.116420033864 1.74155750680245e-05 0.00183732229280068 GO:0140584 chromatin extrusion motor activity 34/1983 151/18639 0.225165562913907 2.116420033864 1.74155750680245e-05 0.00183732229280068 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 34/1983 151/18639 0.225165562913907 2.116420033864 1.74155750680245e-05 0.00183732229280068 GO:0140849 ATP-dependent H2AZ histone chaperone activity 34/1983 151/18639 0.225165562913907 2.116420033864 1.74155750680245e-05 0.00183732229280068 GO:0048029 monosaccharide binding 21/1983 74/18639 0.283783783783784 2.66739583759251 1.8990521190781e-05 0.00183732229280068 GO:0015616 DNA translocase activity 34/1983 152/18639 0.223684210526316 2.10249621785174 2.01745192934977e-05 0.00183732229280068 GO:0140674 ATP-dependent histone chaperone activity 34/1983 152/18639 0.223684210526316 2.10249621785174 2.01745192934977e-05 0.00183732229280068 GO:0061775 cohesin loader activity 34/1983 153/18639 0.222222222222222 2.0887544125063 2.33270265422129e-05 0.00190392937912878 GO:0015399 primary active transmembrane transporter activity 36/1983 166/18639 0.216867469879518 2.03842298087965 2.38924471106357e-05 0.00190392937912878 GO:0003689 DNA clamp loader activity 35/1983 160/18639 0.21875 2.05611762481089 2.5407253282369e-05 0.00190554399617768 GO:0038024 cargo receptor activity 19/1983 65/18639 0.292307692307692 2.74751541952752 2.96867068352815e-05 0.00210280840083244 GO:0042605 peptide antigen binding 15/1983 45/18639 0.333333333333333 3.13313161875946 3.71816582261109e-05 0.00249508495991007 GO:0016887 ATP hydrolysis activity 71/1983 417/18639 0.170263788968825 1.60037658224404 4.23356708933075e-05 0.00269889901944835 GO:0140104 molecular carrier activity 47/1983 249/18639 0.188755020080321 1.77418296483969 6.75510976432317e-05 0.00410131664262478 GO:0031543 peptidyl-proline dioxygenase activity 7/1983 12/18639 0.583333333333333 5.48298033282905 7.44981663037221e-05 0.00431750736532935 GO:0003712 transcription coregulator activity 80/1983 495/18639 0.161616161616162 1.5190941181864 9.06807062287633e-05 0.00502686523659449 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 17/1983 60/18639 0.283333333333333 2.66316187594554 0.000118093474133779 0.00627371581335699 GO:0017154 semaphorin receptor activity 7/1983 13/18639 0.538461538461538 5.06121261491912 0.000146556429304249 0.00747437789451672 GO:0008186 ATP-dependent activity, acting on RNA 20/1983 79/18639 0.253164556962025 2.37959363450085 0.000171468516238751 0.00840855223863107 GO:0008094 ATP-dependent activity, acting on DNA 40/1983 210/18639 0.19047619047619 1.7903609250054 0.000186079383000857 0.00878708197504048 GO:0051213 dioxygenase activity 22/1983 93/18639 0.236559139784946 2.22351276170026 0.000240168201197523 0.0109362305902443 GO:0023026 MHC class II protein complex binding 10/1983 27/18639 0.37037037037037 3.48125735417717 0.000278361029891913 0.012238286659041 GO:0005085 guanyl-nucleotide exchange factor activity 42/1983 230/18639 0.182608695652174 1.71641123462475 0.000335578206046279 0.0142620737569669 GO:0003724 RNA helicase activity 19/1983 77/18639 0.246753246753247 2.31933119830245 0.000352135819579568 0.014483005482708 GO:0045296 cadherin binding 56/1983 334/18639 0.167664670658683 1.57594644296883 0.000388633904450048 0.0147965186472502 GO:0097718 disordered domain specific binding 10/1983 28/18639 0.357142857142857 3.35692673438513 0.000391991700706976 0.0147965186472502 GO:0004386 helicase activity 31/1983 155/18639 0.2 1.87987897125567 0.000394573830593339 0.0147965186472502 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 17/1983 68/18639 0.25 2.34984871406959 0.000601386655488874 0.0219076567356661 GO:0034452 dynactin binding 6/1983 12/18639 0.5 4.69969742813918 0.000753420404498373 0.026683639325984 GO:0003714 transcription corepressor activity 37/1983 204/18639 0.181372549019608 1.704792204325 0.000836539061548404 0.0287185037960264 GO:0019902 phosphatase binding 35/1983 190/18639 0.184210526315789 1.73146747352496 0.000855924034705099 0.0287185037960264 GO:0051020 GTPase binding 52/1983 315/18639 0.165079365079365 1.55164613500468 0.00088566802915264 0.0289545317222978 GO:0140359 ABC-type transporter activity 13/1983 47/18639 0.276595744680851 2.59983261982168 0.000937474118012906 0.0298819875116614 GO:0009055 electron transfer activity 24/1983 116/18639 0.206896551724138 1.94470238405759 0.00104078203686341 0.0323657828536793 GO:0023023 MHC protein complex binding 11/1983 37/18639 0.297297297297297 2.79441468700168 0.00119267031654438 0.0362060631808116 GO:0022853 active monoatomic ion transmembrane transporter activity 24/1983 118/18639 0.203389830508475 1.91174132670068 0.00133464509827691 0.0382425179075328 GO:0031267 small GTPase binding 47/1983 283/18639 0.166077738515901 1.5610302411487 0.00134010752741922 0.0382425179075328 GO:0005044 scavenger receptor activity 9/1983 27/18639 0.333333333333333 3.13313161875946 0.00134973592614822 0.0382425179075328 GO:0005178 integrin binding 30/1983 161/18639 0.186335403726708 1.75144003533137 0.00160368573257408 0.0444499849789555 GO:0019207 kinase regulator activity 47/1983 287/18639 0.163763066202091 1.5392737221083 0.00179953700049235 0.048817227141016 GO:0008559 ABC-type xenobiotic transporter activity 6/1983 14/18639 0.428571428571429 4.02831208126216 0.00202914522894586 0.0538991701438745 GO:0140097 catalytic activity, acting on DNA 53/1983 336/18639 0.157738095238095 1.4826426410201 0.00223557930340755 0.0581706859560127 GO:0019903 protein phosphatase binding 27/1983 144/18639 0.1875 1.76238653555219 0.00243424478863226 0.0620732421101226 GO:0022804 active transmembrane transporter activity 68/1983 457/18639 0.148796498905908 1.39859704644842 0.00272424638112012 0.0681061595280029 GO:0008137 NADH dehydrogenase (ubiquinone) activity 11/1983 41/18639 0.268292682926829 2.52178886387956 0.00295993003551003 0.072575207601448 GO:0001851 complement component C3b binding 5/1983 11/18639 0.454545454545455 4.27245220739926 0.00361086612389699 0.0868651756220504 GO:0140297 DNA-binding transcription factor binding 71/1983 488/18639 0.145491803278689 1.36753490736837 0.00391997902267031 0.0925550602574935 GO:0043394 proteoglycan binding 10/1983 37/18639 0.27027027027027 2.54037698818334 0.00427224632969445 0.0988507587258111 GO:0070006 metalloaminopeptidase activity 8/1983 26/18639 0.307692307692308 2.8921214942395 0.00435826512849629 0.0988507587258111 GO:0048156 tau protein binding 11/1983 43/18639 0.255813953488372 2.40449635858284 0.00441921039009509 0.0988507587258111 GO:0001618 virus receptor activity 17/1983 81/18639 0.209876543209877 1.9727125007004 0.00454299045569982 0.0998674626037461 GO:0019887 protein kinase regulator activity 41/1983 255/18639 0.16078431372549 1.51127525140162 0.00471351937471072 0.101859952589088 GO:0031625 ubiquitin protein ligase binding 47/1983 302/18639 0.155629139072848 1.46281972928835 0.00495946152815341 0.102945299218259 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 53/1983 349/18639 0.151862464183381 1.42741526470703 0.00497992985028245 0.102945299218259 GO:0003713 transcription coactivator activity 41/1983 256/18639 0.16015625 1.50537183245083 0.00505048869333221 0.102945299218259 GO:0140272 exogenous protein binding 17/1983 82/18639 0.207317073170732 1.94865503117966 0.00517614808273491 0.102945299218259 GO:0003954 NADH dehydrogenase activity 11/1983 44/18639 0.25 2.34984871406959 0.0053369147142323 0.102945299218259 GO:0004526 ribonuclease P activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/1983 12/18639 0.416666666666667 3.91641452344932 0.0056518987806103 0.102945299218259 GO:0097110 scaffold protein binding 15/1983 70/18639 0.214285714285714 2.01415604063108 0.00608029375774582 0.104435460653992 GO:0140416 transcription regulator inhibitor activity 9/1983 33/18639 0.272727272727273 2.56347132443955 0.0061827616005025 0.104435460653992 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 6/1983 17/18639 0.352941176470588 3.31743347868648 0.00631954772601512 0.104435460653992 GO:0015278 intracellularly gated calcium channel activity 6/1983 17/18639 0.352941176470588 3.31743347868648 0.00631954772601512 0.104435460653992 GO:0019198 transmembrane receptor protein phosphatase activity 6/1983 17/18639 0.352941176470588 3.31743347868648 0.00631954772601512 0.104435460653992 GO:0038191 neuropilin binding 6/1983 17/18639 0.352941176470588 3.31743347868648 0.00631954772601512 0.104435460653992 GO:1990226 histone methyltransferase binding 6/1983 17/18639 0.352941176470588 3.31743347868648 0.00631954772601512 0.104435460653992 GO:0016776 phosphotransferase activity, phosphate group as acceptor 10/1983 39/18639 0.256410256410256 2.41010124519958 0.00640711246075834 0.104435460653992 GO:0044389 ubiquitin-like protein ligase binding 49/1983 322/18639 0.152173913043478 1.43034269552062 0.00647090305228653 0.104435460653992 GO:0004860 protein kinase inhibitor activity 17/1983 84/18639 0.202380952380952 1.90225848281824 0.00665841179754909 0.106118438023439 GO:0042626 ATPase-coupled transmembrane transporter activity 19/1983 98/18639 0.193877551020408 1.82233165580907 0.00692246516790105 0.10823460255262 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 13/1983 58/18639 0.224137931034483 2.10676091606239 0.0069609705171097 0.10823460255262 GO:0015078 proton transmembrane transporter activity 31/1983 185/18639 0.167567567567568 1.57503373267367 0.00711318734196519 0.108582313109857 GO:0019789 SUMO transferase activity 8/1983 28/18639 0.285714285714286 2.6855413875081 0.00715365827547293 0.108582313109857 GO:0004177 aminopeptidase activity 10/1983 40/18639 0.25 2.34984871406959 0.00774547267215993 0.114831135546557 GO:0140662 ATP-dependent protein folding chaperone 10/1983 40/18639 0.25 2.34984871406959 0.00774547267215993 0.114831135546557 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 7/1983 23/18639 0.304347826086957 2.86068539104124 0.00805457593950099 0.117990197133829 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/1983 13/18639 0.384615384615385 3.61515186779937 0.00838834206468339 0.117990197133829 GO:0005035 death receptor activity 5/1983 13/18639 0.384615384615385 3.61515186779937 0.00838834206468339 0.117990197133829 GO:0032396 inhibitory MHC class I receptor activity 5/1983 13/18639 0.384615384615385 3.61515186779937 0.00838834206468339 0.117990197133829 GO:0051082 unfolded protein binding 22/1983 121/18639 0.181818181818182 1.7089808829597 0.00842126112876737 0.117990197133829 GO:0042277 peptide binding 39/1983 249/18639 0.156626506024096 1.47219437507974 0.0088482450441946 0.120457304276106 GO:0002020 protease binding 24/1983 136/18639 0.176470588235294 1.65871673934324 0.0088807738054541 0.120457304276106 GO:0019838 growth factor binding 24/1983 136/18639 0.176470588235294 1.65871673934324 0.0088807738054541 0.120457304276106 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 11/1983 48/18639 0.229166666666667 2.15402798789713 0.0105953837493548 0.140719940421119 GO:0038187 pattern recognition receptor activity 11/1983 48/18639 0.229166666666667 2.15402798789713 0.0105953837493548 0.140719940421119 GO:0030145 manganese ion binding 14/1983 68/18639 0.205882352941176 1.93516952923378 0.0112620742521556 0.146521884403044 GO:1990841 promoter-specific chromatin binding 14/1983 68/18639 0.205882352941176 1.93516952923378 0.0112620742521556 0.146521884403044 GO:0003725 double-stranded RNA binding 15/1983 75/18639 0.2 1.87987897125567 0.0116099768748416 0.149522429448717 GO:0042813 Wnt receptor activity 5/1983 14/18639 0.357142857142857 3.35692673438513 0.0119212291956487 0.151995672244521 GO:0060590 ATPase regulator activity 11/1983 49/18639 0.224489795918367 2.11006823304208 0.0123825646391255 0.156314553612723 GO:0001848 complement binding 7/1983 25/18639 0.28 2.63183055975794 0.0130779403143114 0.161988901645722 GO:0001540 amyloid-beta binding 16/1983 83/18639 0.192771084337349 1.81193153855969 0.0132278421735342 0.161988901645722 GO:0019210 kinase inhibitor activity 17/1983 90/18639 0.188888888888889 1.77544125063036 0.013250518083138 0.161988901645722 GO:0004857 enzyme inhibitor activity 59/1983 416/18639 0.141826923076923 1.33308725125102 0.0133402624884712 0.161988901645722 GO:0019205 nucleobase-containing compound kinase activity 10/1983 44/18639 0.227272727272727 2.13622610369963 0.0153428768967232 0.176945959793059 GO:0005031 tumor necrosis factor receptor activity 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0008190 eukaryotic initiation factor 4E binding 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0031720 haptoglobin binding 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0033204 ribonuclease P RNA binding 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0035374 chondroitin sulfate binding 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0051880 G-quadruplex DNA binding 4/1983 10/18639 0.4 3.75975794251135 0.0158366226724195 0.176945959793059 GO:0140030 modification-dependent protein binding 28/1983 173/18639 0.161849710982659 1.52128934090054 0.0158657176109223 0.176945959793059 GO:0008157 protein phosphatase 1 binding 7/1983 26/18639 0.269230769230769 2.53060630745956 0.0162904522248749 0.176945959793059 GO:0004129 cytochrome-c oxidase activity 5/1983 15/18639 0.333333333333333 3.13313161875946 0.0163419948813856 0.176945959793059 GO:0015929 hexosaminidase activity 5/1983 15/18639 0.333333333333333 3.13313161875946 0.0163419948813856 0.176945959793059 GO:0019199 transmembrane receptor protein kinase activity 15/1983 78/18639 0.192307692307692 1.80757593389969 0.0164575524589725 0.176945959793059 GO:0031369 translation initiation factor binding 8/1983 32/18639 0.25 2.34984871406959 0.0165149562473522 0.176945959793059 GO:0042910 xenobiotic transmembrane transporter activity 8/1983 32/18639 0.25 2.34984871406959 0.0165149562473522 0.176945959793059 GO:0061659 ubiquitin-like protein ligase activity 53/1983 372/18639 0.14247311827957 1.33916109511493 0.0168131532565916 0.178639753351286 GO:0140311 protein sequestering activity 8/1983 33/18639 0.242424242424242 2.2786411772796 0.0198212585343441 0.207559172973313 GO:0031593 polyubiquitin modification-dependent protein binding 12/1983 59/18639 0.203389830508475 1.91174132670068 0.0199095363441331 0.207559172973313 GO:0035255 ionotropic glutamate receptor binding 7/1983 27/18639 0.259259259259259 2.43688014792402 0.0200233555103667 0.207559172973313 GO:0030291 protein serine/threonine kinase inhibitor activity 10/1983 46/18639 0.217391304347826 2.0433467078866 0.0207538235720572 0.21339616979333 GO:0008238 exopeptidase activity 18/1983 102/18639 0.176470588235294 1.65871673934324 0.0214155318383218 0.218156134344287 GO:0030246 carbohydrate binding 41/1983 280/18639 0.146428571428571 1.3763399610979 0.0216667017613989 0.218156134344287 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/1983 16/18639 0.3125 2.93731089258699 0.0217300620091956 0.218156134344287 GO:0019208 phosphatase regulator activity 20/1983 117/18639 0.170940170940171 1.60673416346639 0.0219862085172087 0.219003248901883 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/1983 60/18639 0.2 1.87987897125567 0.0225533593197368 0.222911109555538 GO:0090482 vitamin transmembrane transporter activity 8/1983 34/18639 0.235294117647059 2.21162231912432 0.0235722709043277 0.231189580023214 GO:0008093 cytoskeletal anchor activity 6/1983 22/18639 0.272727272727273 2.56347132443955 0.0240058287037728 0.231874481797805 GO:0140517 protein-RNA adaptor activity 6/1983 22/18639 0.272727272727273 2.56347132443955 0.0240058287037728 0.231874481797805 GO:0140375 immune receptor activity 25/1983 156/18639 0.16025641025641 1.50631327824974 0.0242811536540505 0.232770457961763 GO:0008201 heparin binding 27/1983 172/18639 0.156976744186047 1.47548640185765 0.0252907127309073 0.238950731749282 GO:0015026 coreceptor activity 12/1983 61/18639 0.19672131147541 1.8490612832023 0.0254472528189033 0.238950731749282 GO:0044183 protein folding chaperone 14/1983 75/18639 0.186666666666667 1.7545537065053 0.0254880780532568 0.238950731749282 GO:0036121 double-stranded DNA helicase activity 10/1983 48/18639 0.208333333333333 1.95820726172466 0.0274354648044622 0.252004636234047 GO:0140693 molecular condensate scaffold activity 10/1983 48/18639 0.208333333333333 1.95820726172466 0.0274354648044622 0.252004636234047 GO:0004549 tRNA-specific ribonuclease activity 5/1983 17/18639 0.294117647058824 2.7645278989054 0.0281511096271875 0.252004636234047 GO:0004550 nucleoside diphosphate kinase activity 5/1983 17/18639 0.294117647058824 2.7645278989054 0.0281511096271875 0.252004636234047 GO:0030169 low-density lipoprotein particle binding 5/1983 17/18639 0.294117647058824 2.7645278989054 0.0281511096271875 0.252004636234047 GO:0032183 SUMO binding 5/1983 17/18639 0.294117647058824 2.7645278989054 0.0281511096271875 0.252004636234047 GO:0140313 molecular sequestering activity 11/1983 55/18639 0.2 1.87987897125567 0.0282640493972303 0.252004636234047 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 6/1983 23/18639 0.260869565217391 2.45201604946392 0.0296356826205746 0.262399273203004 GO:0003995 acyl-CoA dehydrogenase activity 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0004875 complement receptor activity 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0016208 AMP binding 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0097677 STAT family protein binding 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:1990459 transferrin receptor binding 4/1983 12/18639 0.333333333333333 3.13313161875946 0.0314082045170578 0.265201726882441 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 7/1983 30/18639 0.233333333333333 2.19319213313162 0.0346933463888092 0.29101326740613 GO:0032393 MHC class I receptor activity 5/1983 18/18639 0.277777777777778 2.61094301563288 0.0356559739374556 0.291034252470517 GO:0034185 apolipoprotein binding 5/1983 18/18639 0.277777777777778 2.61094301563288 0.0356559739374556 0.291034252470517 GO:0035615 clathrin adaptor activity 5/1983 18/18639 0.277777777777778 2.61094301563288 0.0356559739374556 0.291034252470517 GO:0015295 solute:proton symporter activity 6/1983 24/18639 0.25 2.34984871406959 0.036065421090464 0.291034252470517 GO:0030215 semaphorin receptor binding 6/1983 24/18639 0.25 2.34984871406959 0.036065421090464 0.291034252470517 GO:0048027 mRNA 5'-UTR binding 6/1983 24/18639 0.25 2.34984871406959 0.036065421090464 0.291034252470517 GO:0061134 peptidase regulator activity 33/1983 226/18639 0.146017699115044 1.37247800998755 0.0375494879503765 0.301104384507736 GO:0005518 collagen binding 13/1983 72/18639 0.180555555555556 1.69711296016137 0.0390127201816628 0.310882613947625 GO:0004713 protein tyrosine kinase activity 22/1983 140/18639 0.157142857142857 1.47704776312946 0.0399646491714781 0.316490234121954 GO:0017147 Wnt-protein binding 7/1983 31/18639 0.225806451612903 2.12244399980479 0.0408382287415238 0.317904487917729 GO:0070325 lipoprotein particle receptor binding 7/1983 31/18639 0.225806451612903 2.12244399980479 0.0408382287415238 0.317904487917729 GO:0008035 high-density lipoprotein particle binding 4/1983 13/18639 0.307692307692308 2.8921214942395 0.0416392544958908 0.317904487917729 GO:0039706 co-receptor binding 4/1983 13/18639 0.307692307692308 2.8921214942395 0.0416392544958908 0.317904487917729 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/1983 13/18639 0.307692307692308 2.8921214942395 0.0416392544958908 0.317904487917729 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/1983 13/18639 0.307692307692308 2.8921214942395 0.0416392544958908 0.317904487917729 GO:0016853 isomerase activity 27/1983 180/18639 0.15 1.40990922844175 0.0419358812672917 0.318263384617839 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/1983 25/18639 0.24 2.25585476550681 0.0433246255460912 0.326857382078499 GO:0050145 nucleoside monophosphate kinase activity 5/1983 19/18639 0.263157894736842 2.47352496217852 0.0442801164987891 0.332100873740918 GO:0046915 transition metal ion transmembrane transporter activity 9/1983 45/18639 0.2 1.87987897125567 0.0447950221149942 0.332289189684231 GO:0061630 ubiquitin protein ligase activity 48/1983 353/18639 0.135977337110482 1.27810468300669 0.0450783985228915 0.332289189684231 GO:0051087 protein-folding chaperone binding 21/1983 134/18639 0.156716417910448 1.47303949240183 0.0450870822081349 0.332289189684231 GO:0005543 phospholipid binding 65/1983 497/18639 0.130784708249497 1.22929711400019 0.0462443593076169 0.338859529409262 GO:0003678 DNA helicase activity 13/1983 74/18639 0.175675675675676 1.65124504231917 0.0473107463901854 0.341304213066641 GO:0071813 lipoprotein particle binding 7/1983 32/18639 0.21875 2.05611762481089 0.0476487450398918 0.341304213066641 GO:0071814 protein-lipid complex binding 7/1983 32/18639 0.21875 2.05611762481089 0.0476487450398918 0.341304213066641 GO:0120015 sterol transfer activity 7/1983 32/18639 0.21875 2.05611762481089 0.0476487450398918 0.341304213066641 GO:0001216 DNA-binding transcription activator activity 64/1983 491/18639 0.130346232179226 1.22517570428068 0.0503847383846263 0.358885706370942 GO:0008198 ferrous iron binding 6/1983 26/18639 0.230769230769231 2.16909112067962 0.051434877542456 0.360326752014458 GO:0030247 polysaccharide binding 6/1983 26/18639 0.230769230769231 2.16909112067962 0.051434877542456 0.360326752014458 GO:0050750 low-density lipoprotein particle receptor binding 6/1983 26/18639 0.230769230769231 2.16909112067962 0.051434877542456 0.360326752014458 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 63/1983 484/18639 0.130165289256198 1.2234749503007 0.0530523548049964 0.364579737113823 GO:0005344 oxygen carrier activity 4/1983 14/18639 0.285714285714286 2.6855413875081 0.0535264646159878 0.364579737113823 GO:0061665 SUMO ligase activity 4/1983 14/18639 0.285714285714286 2.6855413875081 0.0535264646159878 0.364579737113823 GO:0004725 protein tyrosine phosphatase activity 16/1983 98/18639 0.163265306122449 1.53459507857606 0.0539990456677219 0.364579737113823 GO:0000339 RNA cap binding 5/1983 20/18639 0.25 2.34984871406959 0.0540435845604021 0.364579737113823 GO:0016004 phospholipase activator activity 5/1983 20/18639 0.25 2.34984871406959 0.0540435845604021 0.364579737113823 GO:0042288 MHC class I protein binding 5/1983 20/18639 0.25 2.34984871406959 0.0540435845604021 0.364579737113823 GO:0008135 translation factor activity, RNA binding 14/1983 83/18639 0.168674698795181 1.58544009623972 0.054494945314477 0.365689764610306 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/1983 40/18639 0.2 1.87987897125567 0.0567253288958754 0.372498112989425 GO:0098631 cell adhesion mediator activity 13/1983 76/18639 0.171052631578947 1.60779122541604 0.056755691182466 0.372498112989425 GO:0001784 phosphotyrosine residue binding 9/1983 47/18639 0.191489361702128 1.79988412141501 0.0569702996336768 0.372498112989425 GO:0061749 forked DNA-dependent helicase activity 9/1983 47/18639 0.191489361702128 1.79988412141501 0.0569702996336768 0.372498112989425 GO:1990518 single-stranded 3'-5' DNA helicase activity 9/1983 47/18639 0.191489361702128 1.79988412141501 0.0569702996336768 0.372498112989425 GO:0005506 iron ion binding 23/1983 154/18639 0.149350649350649 1.40380572528833 0.0592338594351908 0.383580595591631 GO:0180051 translation factor activity 14/1983 84/18639 0.166666666666667 1.56656580937973 0.0592669626129815 0.383580595591631 GO:0019888 protein phosphatase regulator activity 17/1983 107/18639 0.158878504672897 1.49336179959563 0.0596732477277646 0.384259549762121 GO:0001671 ATPase activator activity 6/1983 27/18639 0.222222222222222 2.0887544125063 0.060409598123053 0.387046420135139 GO:0017124 SH3 domain binding 18/1983 115/18639 0.156521739130435 1.47120962967835 0.0607295605387736 0.387150948434681 GO:0098632 cell-cell adhesion mediator activity 10/1983 55/18639 0.181818181818182 1.7089808829597 0.0625959998791061 0.394347695827127 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/1983 34/18639 0.205882352941176 1.93516952923378 0.0633251839017052 0.394347695827127 GO:0009378 four-way junction helicase activity 9/1983 48/18639 0.1875 1.76238653555219 0.0637860307481109 0.394347695827127 GO:0043138 3'-5' DNA helicase activity 9/1983 48/18639 0.1875 1.76238653555219 0.0637860307481109 0.394347695827127 GO:0001530 lipopolysaccharide binding 8/1983 41/18639 0.195121951219512 1.83402826463968 0.0641867407057015 0.394347695827127 GO:0042287 MHC protein binding 8/1983 41/18639 0.195121951219512 1.83402826463968 0.0641867407057015 0.394347695827127 GO:0001846 opsonin binding 5/1983 21/18639 0.238095238095238 2.23795115625675 0.0649513851950563 0.394347695827127 GO:0005123 death receptor binding 5/1983 21/18639 0.238095238095238 2.23795115625675 0.0649513851950563 0.394347695827127 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/1983 21/18639 0.238095238095238 2.23795115625675 0.0649513851950563 0.394347695827127 GO:0140312 cargo adaptor activity 5/1983 21/18639 0.238095238095238 2.23795115625675 0.0649513851950563 0.394347695827127 GO:0000774 adenyl-nucleotide exchange factor activity 4/1983 15/18639 0.266666666666667 2.50650529500756 0.0670480899740248 0.403237333570196 GO:0004559 alpha-mannosidase activity 4/1983 15/18639 0.266666666666667 2.50650529500756 0.0670480899740248 0.403237333570196 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 26/1983 181/18639 0.143646408839779 1.35018931637148 0.0695596497384944 0.416378185054368 GO:0045499 chemorepellent activity 6/1983 28/18639 0.214285714285714 2.01415604063108 0.0702540554506135 0.41856972289501 GO:0016763 pentosyltransferase activity 9/1983 49/18639 0.183673469387755 1.72641946339807 0.0710964715374317 0.421618610280118 GO:0005154 epidermal growth factor receptor binding 7/1983 35/18639 0.2 1.87987897125567 0.0722078927196761 0.426227144525866 GO:0046332 SMAD binding 13/1983 79/18639 0.164556962025316 1.54673586242555 0.0731787447501878 0.429967279062163 GO:0003779 actin binding 57/1983 443/18639 0.128668171557562 1.20940294990489 0.0747121100384747 0.435774379174737 GO:0019842 vitamin binding 22/1983 150/18639 0.146666666666667 1.37857791225416 0.0748506580700136 0.435774379174737 GO:0008081 phosphoric diester hydrolase activity 14/1983 87/18639 0.160919540229885 1.51254629871146 0.0752473499346294 0.436092596212057 GO:0016504 peptidase activator activity 10/1983 57/18639 0.175438596491228 1.64901664145234 0.0763717221339908 0.437731819473328 GO:0004721 phosphoprotein phosphatase activity 25/1983 175/18639 0.142857142857143 1.34277069375405 0.077803562059497 0.437731819473328 GO:0019787 ubiquitin-like protein transferase activity 61/1983 479/18639 0.127348643006263 1.1970001800271 0.0785880884157818 0.437731819473328 GO:1902936 phosphatidylinositol bisphosphate binding 17/1983 111/18639 0.153153153153153 1.43954695997056 0.078739238485059 0.437731819473328 GO:0004629 phospholipase C activity 6/1983 29/18639 0.206896551724138 1.94470238405759 0.0809655226970198 0.437731819473328 GO:0099604 ligand-gated calcium channel activity 6/1983 29/18639 0.206896551724138 1.94470238405759 0.0809655226970198 0.437731819473328 GO:0004197 cysteine-type endopeptidase activity 14/1983 88/18639 0.159090909090909 1.49535827258974 0.0811409225042709 0.437731819473328 GO:0061135 endopeptidase regulator activity 26/1983 184/18639 0.141304347826087 1.32817536012629 0.0811773260064301 0.437731819473328 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0030957 Tat protein binding 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0031434 mitogen-activated protein kinase kinase binding 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0032395 MHC class II receptor activity 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 3/1983 10/18639 0.3 2.81981845688351 0.081566382771244 0.437731819473328 GO:0005539 glycosaminoglycan binding 33/1983 242/18639 0.136363636363636 1.28173566221978 0.0816142744425946 0.437731819473328 GO:0045505 dynein intermediate chain binding 7/1983 36/18639 0.194444444444444 1.82766011094302 0.0817897380734426 0.437731819473328 GO:0015923 mannosidase activity 4/1983 16/18639 0.25 2.34984871406959 0.0821540992956345 0.437731819473328 GO:0022858 alanine transmembrane transporter activity 4/1983 16/18639 0.25 2.34984871406959 0.0821540992956345 0.437731819473328 GO:0051015 actin filament binding 29/1983 209/18639 0.138755980861244 1.30422225278504 0.0823965777832148 0.437731819473328 GO:0017116 single-stranded DNA helicase activity 10/1983 58/18639 0.172413793103448 1.62058532004799 0.0839126684575845 0.442830220772636 GO:0016779 nucleotidyltransferase activity 20/1983 136/18639 0.147058823529412 1.3822639494527 0.0843982303119612 0.442830220772636 GO:0044325 transmembrane transporter binding 20/1983 136/18639 0.147058823529412 1.3822639494527 0.0843982303119612 0.442830220772636 GO:0003743 translation initiation factor activity 9/1983 51/18639 0.176470588235294 1.65871673934324 0.0872149721110646 0.447684803023295 GO:0005021 vascular endothelial growth factor receptor activity 9/1983 51/18639 0.176470588235294 1.65871673934324 0.0872149721110646 0.447684803023295 GO:0003727 single-stranded RNA binding 14/1983 89/18639 0.157303370786517 1.47855649424603 0.0873220774398771 0.447684803023295 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 14/1983 89/18639 0.157303370786517 1.47855649424603 0.0873220774398771 0.447684803023295 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 14/1983 89/18639 0.157303370786517 1.47855649424603 0.0873220774398771 0.447684803023295 GO:0008235 metalloexopeptidase activity 11/1983 66/18639 0.166666666666667 1.56656580937973 0.0876506390890972 0.447684803023295 GO:0004866 endopeptidase inhibitor activity 23/1983 161/18639 0.142857142857143 1.34277069375405 0.0877813339261363 0.447684803023295 GO:0030547 signaling receptor inhibitor activity 8/1983 44/18639 0.181818181818182 1.7089808829597 0.0900630773765004 0.451388920414104 GO:0003887 DNA-directed DNA polymerase activity 5/1983 23/18639 0.217391304347826 2.0433467078866 0.0901493385131234 0.451388920414104 GO:0005158 insulin receptor binding 5/1983 23/18639 0.217391304347826 2.0433467078866 0.0901493385131234 0.451388920414104 GO:0070577 lysine-acetylated histone binding 5/1983 23/18639 0.217391304347826 2.0433467078866 0.0901493385131234 0.451388920414104 GO:0042578 phosphoric ester hydrolase activity 47/1983 363/18639 0.129476584022039 1.21700153786524 0.0902935964665965 0.451388920414104 GO:0005319 lipid transporter activity 25/1983 178/18639 0.140449438202247 1.32013972700539 0.0906318146086358 0.451388920414104 GO:0036002 pre-mRNA binding 10/1983 59/18639 0.169491525423729 1.59311777225057 0.0918908886050581 0.453770375526701 GO:0045309 protein phosphorylated amino acid binding 10/1983 59/18639 0.169491525423729 1.59311777225057 0.0918908886050581 0.453770375526701 GO:0001968 fibronectin binding 6/1983 30/18639 0.2 1.87987897125567 0.0925335667740724 0.453770375526701 GO:0048019 receptor antagonist activity 6/1983 30/18639 0.2 1.87987897125567 0.0925335667740724 0.453770375526701 GO:0140793 histone H2AXY142 phosphatase activity 14/1983 90/18639 0.155555555555556 1.46212808875441 0.0937922050954792 0.458180312248031 GO:0005080 protein kinase C binding 9/1983 52/18639 0.173076923076923 1.62681834050972 0.0960236590607185 0.463081412276033 GO:0070403 NAD+ binding 4/1983 17/18639 0.235294117647059 2.21162231912432 0.0987704038090029 0.463081412276033 GO:0051539 4 iron, 4 sulfur cluster binding 8/1983 45/18639 0.177777777777778 1.67100353000504 0.0998507650006097 0.463081412276033 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 10/1983 60/18639 0.166666666666667 1.56656580937973 0.100305489054311 0.463081412276033 GO:0016755 aminoacyltransferase activity 62/1983 496/18639 0.125 1.1749243570348 0.100630170988435 0.463081412276033 GO:0031072 heat shock protein binding 19/1983 131/18639 0.145038167938931 1.36327100968923 0.100660099789644 0.463081412276033 GO:0042393 histone binding 33/1983 247/18639 0.133603238866397 1.25578959618294 0.100692857248386 0.463081412276033 GO:0042887 amide transmembrane transporter activity 7/1983 38/18639 0.184210526315789 1.73146747352496 0.10302962042416 0.463081412276033 GO:0043531 ADP binding 7/1983 38/18639 0.184210526315789 1.73146747352496 0.10302962042416 0.463081412276033 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0005114 type II transforming growth factor beta receptor binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0005536 D-glucose binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0034713 type I transforming growth factor beta receptor binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0042608 T cell receptor binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0048185 activin binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0048407 platelet-derived growth factor binding 3/1983 11/18639 0.272727272727273 2.56347132443955 0.10359523783362 0.463081412276033 GO:0004622 lysophospholipase activity 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0015149 hexose transmembrane transporter activity 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0035035 histone acetyltransferase binding 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0050431 transforming growth factor beta binding 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0055056 D-glucose transmembrane transporter activity 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0060229 lipase activator activity 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0140033 acetylation-dependent protein binding 5/1983 24/18639 0.208333333333333 1.95820726172466 0.104381948361192 0.463081412276033 GO:0004864 protein phosphatase inhibitor activity 9/1983 53/18639 0.169811320754717 1.59612365483972 0.105328321223568 0.463081412276033 GO:0005003 ephrin receptor activity 9/1983 53/18639 0.169811320754717 1.59612365483972 0.105328321223568 0.463081412276033 GO:0005005 transmembrane-ephrin receptor activity 9/1983 53/18639 0.169811320754717 1.59612365483972 0.105328321223568 0.463081412276033 GO:0140296 general transcription initiation factor binding 9/1983 53/18639 0.169811320754717 1.59612365483972 0.105328321223568 0.463081412276033 GO:0030276 clathrin binding 8/1983 46/18639 0.173913043478261 1.63467736630928 0.110210319480731 0.48288026576609 GO:0002039 p53 binding 11/1983 69/18639 0.159420289855072 1.49845425245017 0.111765303390721 0.488016307613592 GO:1990782 protein tyrosine kinase binding 17/1983 117/18639 0.145299145299145 1.36572403894643 0.114145562483559 0.49588549179285 GO:0051219 phosphoprotein binding 14/1983 93/18639 0.150537634408602 1.41496266653653 0.114938704784274 0.49588549179285 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 9/1983 54/18639 0.166666666666667 1.56656580937973 0.115123220055438 0.49588549179285 GO:0051287 NAD binding 9/1983 54/18639 0.166666666666667 1.56656580937973 0.115123220055438 0.49588549179285 GO:0070064 proline-rich region binding 4/1983 18/18639 0.222222222222222 2.0887544125063 0.116803098058016 0.498526162770694 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1983 18/18639 0.222222222222222 2.0887544125063 0.116803098058016 0.498526162770694 GO:0008378 galactosyltransferase activity 6/1983 32/18639 0.1875 1.76238653555219 0.118161610100805 0.498526162770694 GO:0030515 snoRNA binding 6/1983 32/18639 0.1875 1.76238653555219 0.118161610100805 0.498526162770694 GO:0015662 P-type ion transporter activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0019211 phosphatase activator activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0019707 protein-cysteine S-acyltransferase activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0120020 cholesterol transfer activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0140358 P-type transmembrane transporter activity 5/1983 25/18639 0.2 1.87987897125567 0.119646279064967 0.498526162770694 GO:0004222 metalloendopeptidase activity 16/1983 110/18639 0.145454545454545 1.36718470636776 0.121686108953691 0.505373905263701 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 13/1983 86/18639 0.151162790697674 1.4208387573444 0.122455351072895 0.506917443564742 GO:0005201 extracellular matrix structural constituent 23/1983 168/18639 0.136904761904762 1.28682191484763 0.124181548262341 0.51239959234461 GO:0005165 neurotrophin receptor binding 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0008179 adenylate cyclase binding 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0016801 hydrolase activity, acting on ether bonds 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0016803 ether hydrolase activity 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0017166 vinculin binding 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0070008 serine-type exopeptidase activity 3/1983 12/18639 0.25 2.34984871406959 0.127657582272474 0.51670926157906 GO:0019955 cytokine binding 20/1983 144/18639 0.138888888888889 1.30547150781644 0.129860508302433 0.523006270934803 GO:0030414 peptidase inhibitor activity 23/1983 169/18639 0.136094674556213 1.27920758399055 0.13003371598928 0.523006270934803 GO:0032266 phosphatidylinositol-3-phosphate binding 8/1983 48/18639 0.166666666666667 1.56656580937973 0.132600412881915 0.531652598818998 GO:0004435 phosphatidylinositol phospholipase C activity 5/1983 26/18639 0.192307692307692 1.80757593389969 0.135887088951279 0.532485341874143 GO:0005160 transforming growth factor beta receptor binding 5/1983 26/18639 0.192307692307692 1.80757593389969 0.135887088951279 0.532485341874143 GO:0015145 monosaccharide transmembrane transporter activity 5/1983 26/18639 0.192307692307692 1.80757593389969 0.135887088951279 0.532485341874143 GO:0034237 protein kinase A regulatory subunit binding 5/1983 26/18639 0.192307692307692 1.80757593389969 0.135887088951279 0.532485341874143 GO:0052742 phosphatidylinositol kinase activity 5/1983 26/18639 0.192307692307692 1.80757593389969 0.135887088951279 0.532485341874143 GO:0046624 sphingolipid transporter activity 4/1983 19/18639 0.210526315789474 1.97881996974281 0.136142559807144 0.532485341874143 GO:0140036 ubiquitin-modified protein reader activity 4/1983 19/18639 0.210526315789474 1.97881996974281 0.136142559807144 0.532485341874143 GO:0019212 phosphatase inhibitor activity 9/1983 56/18639 0.160714285714286 1.51061703047331 0.136149193294879 0.532485341874143 GO:0031406 carboxylic acid binding 25/1983 187/18639 0.133689839572193 1.25660359041155 0.137095025099903 0.534544822637236 GO:0008083 growth factor activity 22/1983 162/18639 0.135802469135802 1.27646102986496 0.138413636426055 0.537183874605744 GO:0016651 oxidoreductase activity, acting on NAD(P)H 13/1983 88/18639 0.147727272727273 1.38854696740476 0.139347321088245 0.537183874605744 GO:0001727 lipid kinase activity 7/1983 41/18639 0.170731707317073 1.60477473155972 0.139878467740476 0.537183874605744 GO:0016877 ligase activity, forming carbon-sulfur bonds 7/1983 41/18639 0.170731707317073 1.60477473155972 0.139878467740476 0.537183874605744 GO:0042169 SH2 domain binding 7/1983 41/18639 0.170731707317073 1.60477473155972 0.139878467740476 0.537183874605744 GO:0008376 acetylgalactosaminyltransferase activity 6/1983 34/18639 0.176470588235294 1.65871673934324 0.146917898903399 0.559044079348419 GO:0120013 lipid transfer activity 10/1983 65/18639 0.153846153846154 1.44606074711975 0.148765783220744 0.559044079348419 GO:0043177 organic acid binding 25/1983 189/18639 0.132275132275132 1.24330619792042 0.149046524566357 0.559044079348419 GO:0004364 glutathione transferase activity 5/1983 27/18639 0.185185185185185 1.74062867708859 0.153041064139512 0.559044079348419 GO:0005385 zinc ion transmembrane transporter activity 5/1983 27/18639 0.185185185185185 1.74062867708859 0.153041064139512 0.559044079348419 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/1983 27/18639 0.185185185185185 1.74062867708859 0.153041064139512 0.559044079348419 GO:0005172 vascular endothelial growth factor receptor binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0005542 folic acid binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0035673 oligopeptide transmembrane transporter activity 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0043560 insulin receptor substrate binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0046974 histone H3K9 methyltransferase activity 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0051011 microtubule minus-end binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0071714 icosanoid transmembrane transporter activity 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0071837 HMG box domain binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0089720 caspase binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0097157 pre-mRNA intronic binding 3/1983 13/18639 0.230769230769231 2.16909112067962 0.153463080605448 0.559044079348419 GO:0005516 calmodulin binding 27/1983 207/18639 0.130434782608696 1.22600802473196 0.154962795960386 0.562699850865956 GO:0015095 magnesium ion transmembrane transporter activity 4/1983 20/18639 0.2 1.87987897125567 0.156667303618829 0.562699850865956 GO:0016505 peptidase activator activity involved in apoptotic process 4/1983 20/18639 0.2 1.87987897125567 0.156667303618829 0.562699850865956 GO:0043024 ribosomal small subunit binding 4/1983 20/18639 0.2 1.87987897125567 0.156667303618829 0.562699850865956 GO:0032813 tumor necrosis factor receptor superfamily binding 8/1983 50/18639 0.16 1.50390317700454 0.157114625026102 0.562699850865956 GO:0048020 CCR chemokine receptor binding 8/1983 50/18639 0.16 1.50390317700454 0.157114625026102 0.562699850865956 GO:0015103 inorganic anion transmembrane transporter activity 22/1983 165/18639 0.133333333333333 1.25325264750378 0.158125953511942 0.564735548256936 GO:0034061 DNA polymerase activity 6/1983 35/18639 0.171428571428571 1.61132483250486 0.1623751415621 0.578291356122004 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 13/1983 91/18639 0.142857142857143 1.34277069375405 0.16692127271287 0.580166176690907 GO:0072341 modified amino acid binding 13/1983 91/18639 0.142857142857143 1.34277069375405 0.16692127271287 0.580166176690907 GO:0004518 nuclease activity 27/1983 209/18639 0.129186602870813 1.214275890524 0.167199188227675 0.580166176690907 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/1983 43/18639 0.162790697674419 1.5301340463709 0.167516103470327 0.580166176690907 GO:0008375 acetylglucosaminyltransferase activity 7/1983 43/18639 0.162790697674419 1.5301340463709 0.167516103470327 0.580166176690907 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/1983 43/18639 0.162790697674419 1.5301340463709 0.167516103470327 0.580166176690907 GO:0030165 PDZ domain binding 12/1983 83/18639 0.144578313253012 1.35894865391976 0.16870040076056 0.580166176690907 GO:0005010 insulin-like growth factor receptor activity 8/1983 51/18639 0.156862745098039 1.47441487941621 0.170119211614947 0.580166176690907 GO:0005272 sodium channel activity 8/1983 51/18639 0.156862745098039 1.47441487941621 0.170119211614947 0.580166176690907 GO:0046875 ephrin receptor binding 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0046966 nuclear thyroid hormone receptor binding 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0051119 sugar transmembrane transporter activity 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0051959 dynein light intermediate chain binding 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0141052 histone H3 demethylase activity 5/1983 28/18639 0.178571428571429 1.67846336719257 0.171038239941446 0.580166176690907 GO:0001786 phosphatidylserine binding 9/1983 59/18639 0.152542372881356 1.43380599502551 0.171092143086887 0.580166176690907 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/1983 59/18639 0.152542372881356 1.43380599502551 0.171092143086887 0.580166176690907 GO:0070063 RNA polymerase binding 9/1983 59/18639 0.152542372881356 1.43380599502551 0.171092143086887 0.580166176690907 GO:0008237 metallopeptidase activity 24/1983 184/18639 0.130434782608696 1.22600802473196 0.17170886689948 0.580713011397446 GO:0010314 phosphatidylinositol-5-phosphate binding 4/1983 21/18639 0.19047619047619 1.7903609250054 0.17824751971854 0.590810550501423 GO:0019200 carbohydrate kinase activity 4/1983 21/18639 0.19047619047619 1.7903609250054 0.17824751971854 0.590810550501423 GO:0036122 BMP binding 4/1983 21/18639 0.19047619047619 1.7903609250054 0.17824751971854 0.590810550501423 GO:0061891 calcium ion sensor activity 4/1983 21/18639 0.19047619047619 1.7903609250054 0.17824751971854 0.590810550501423 GO:0070182 DNA polymerase binding 4/1983 21/18639 0.19047619047619 1.7903609250054 0.17824751971854 0.590810550501423 GO:0016409 palmitoyltransferase activity 6/1983 36/18639 0.166666666666667 1.56656580937973 0.178492222259831 0.590810550501423 GO:0004620 phospholipase activity 15/1983 109/18639 0.137614678899083 1.29349470499244 0.180500784704857 0.590810550501423 GO:0005347 ATP transmembrane transporter activity 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0005545 1-phosphatidylinositol binding 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0008191 metalloendopeptidase inhibitor activity 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0032036 myosin heavy chain binding 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0042043 neurexin family protein binding 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0098847 sequence-specific single stranded DNA binding 3/1983 14/18639 0.214285714285714 2.01415604063108 0.180718521329847 0.590810550501423 GO:0004842 ubiquitin-protein transferase activity 54/1983 449/18639 0.120267260579065 1.13043947046555 0.186110162498725 0.606880964669756 GO:0004175 endopeptidase activity 49/1983 405/18639 0.120987654320988 1.13721073569788 0.187618042369061 0.61023725515447 GO:0016417 S-acyltransferase activity 5/1983 29/18639 0.172413793103448 1.62058532004799 0.189803389367369 0.61110939758433 GO:0035250 UDP-galactosyltransferase activity 5/1983 29/18639 0.172413793103448 1.62058532004799 0.189803389367369 0.61110939758433 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/1983 29/18639 0.172413793103448 1.62058532004799 0.189803389367369 0.61110939758433 GO:0051861 glycolipid binding 5/1983 29/18639 0.172413793103448 1.62058532004799 0.189803389367369 0.61110939758433 GO:0004519 endonuclease activity 17/1983 127/18639 0.133858267716535 1.25818671304514 0.191179634473413 0.612447321491461 GO:0042826 histone deacetylase binding 17/1983 127/18639 0.133858267716535 1.25818671304514 0.191179634473413 0.612447321491461 GO:0140789 histone phosphatase activity 18/1983 136/18639 0.132352941176471 1.24403755450743 0.19568684766277 0.622759195576284 GO:0008009 chemokine activity 7/1983 45/18639 0.155555555555556 1.46212808875441 0.19733333382823 0.622759195576284 GO:0141110 transporter inhibitor activity 7/1983 45/18639 0.155555555555556 1.46212808875441 0.19733333382823 0.622759195576284 GO:0051018 protein kinase A binding 8/1983 53/18639 0.150943396226415 1.41877658207975 0.197504518534521 0.622759195576284 GO:0005126 cytokine receptor binding 34/1983 275/18639 0.123636363636364 1.1621070004126 0.199365197506351 0.622759195576284 GO:0008194 UDP-glycosyltransferase activity 19/1983 145/18639 0.131034482758621 1.23164484323648 0.199738644738108 0.622759195576284 GO:0016209 antioxidant activity 12/1983 86/18639 0.13953488372093 1.31154346831791 0.200520063638453 0.622759195576284 GO:0035091 phosphatidylinositol binding 35/1983 284/18639 0.123239436619718 1.15837612665402 0.200726176824977 0.622759195576284 GO:0008649 rRNA methyltransferase activity 4/1983 22/18639 0.181818181818182 1.7089808829597 0.200748258338708 0.622759195576284 GO:0015377 chloride:monoatomic cation symporter activity 4/1983 22/18639 0.181818181818182 1.7089808829597 0.200748258338708 0.622759195576284 GO:0070034 telomerase RNA binding 4/1983 22/18639 0.181818181818182 1.7089808829597 0.200748258338708 0.622759195576284 GO:0140035 ubiquitin-like protein reader activity 4/1983 22/18639 0.181818181818182 1.7089808829597 0.200748258338708 0.622759195576284 GO:0140784 metal ion sensor activity 4/1983 22/18639 0.181818181818182 1.7089808829597 0.200748258338708 0.622759195576284 GO:0016922 nuclear receptor binding 18/1983 137/18639 0.131386861313869 1.23495698841614 0.204344478291703 0.626204966973338 GO:0032182 ubiquitin-like protein binding 16/1983 120/18639 0.133333333333333 1.25325264750378 0.204483469941502 0.626204966973338 GO:0004867 serine-type endopeptidase inhibitor activity 13/1983 95/18639 0.136842105263158 1.28623298033283 0.207561570611193 0.626204966973338 GO:0016846 carbon-sulfur lyase activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0017081 chloride channel regulator activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0034483 heparan sulfate sulfotransferase activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0042809 nuclear vitamin D receptor binding 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0047372 monoacylglycerol lipase activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0048531 beta-1,3-galactosyltransferase activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0050700 CARD domain binding 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0050780 dopamine receptor binding 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0140776 protein-containing complex destabilizing activity 3/1983 15/18639 0.2 1.87987897125567 0.209136129168802 0.626204966973338 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/1983 30/18639 0.166666666666667 1.56656580937973 0.209257353886028 0.626204966973338 GO:0032452 histone demethylase activity 5/1983 30/18639 0.166666666666667 1.56656580937973 0.209257353886028 0.626204966973338 GO:0015179 L-amino acid transmembrane transporter activity 9/1983 62/18639 0.145161290322581 1.3644282855888 0.209717271292247 0.626204966973338 GO:0140463 chromatin-protein adaptor activity 8/1983 54/18639 0.148148148148148 1.39250294167087 0.21183170087871 0.631040697711109 GO:0003697 single-stranded DNA binding 16/1983 121/18639 0.132231404958678 1.24289518760706 0.213953978054086 0.635877207503402 GO:0140299 molecular sensor activity 10/1983 71/18639 0.140845070422535 1.32385843046174 0.219653599774862 0.651298464448719 GO:1901682 sulfur compound transmembrane transporter activity 9/1983 63/18639 0.142857142857143 1.34277069375405 0.223314951331848 0.659679232936147 GO:0043274 phospholipase binding 4/1983 23/18639 0.173913043478261 1.63467736630928 0.224032241459884 0.659679232936147 GO:0140102 catalytic activity, acting on a rRNA 4/1983 23/18639 0.173913043478261 1.63467736630928 0.224032241459884 0.659679232936147 GO:0048306 calcium-dependent protein binding 11/1983 80/18639 0.1375 1.29241679273828 0.227875422294495 0.66944968531217 GO:0070273 phosphatidylinositol-4-phosphate binding 5/1983 31/18639 0.161290322580645 1.51603142843199 0.229318297344517 0.670598231913438 GO:0140457 protein demethylase activity 5/1983 31/18639 0.161290322580645 1.51603142843199 0.229318297344517 0.670598231913438 GO:0140098 catalytic activity, acting on RNA 46/1983 387/18639 0.118863049095607 1.11724073227081 0.232380313856677 0.677997483220283 GO:0005024 transforming growth factor beta receptor activity 3/1983 16/18639 0.1875 1.76238653555219 0.238439674524149 0.689366405937165 GO:0005159 insulin-like growth factor receptor binding 3/1983 16/18639 0.1875 1.76238653555219 0.238439674524149 0.689366405937165 GO:0015562 efflux transmembrane transporter activity 3/1983 16/18639 0.1875 1.76238653555219 0.238439674524149 0.689366405937165 GO:0017070 U6 snRNA binding 3/1983 16/18639 0.1875 1.76238653555219 0.238439674524149 0.689366405937165 GO:1901981 phosphatidylinositol phosphate binding 23/1983 185/18639 0.124324324324324 1.16857341456434 0.244433439035679 0.705096458756768 GO:0004521 RNA endonuclease activity 10/1983 73/18639 0.136986301369863 1.28758833647649 0.245849649011245 0.705696278128388 GO:0043539 protein serine/threonine kinase activator activity 10/1983 73/18639 0.136986301369863 1.28758833647649 0.245849649011245 0.705696278128388 GO:0033218 amide binding 30/1983 247/18639 0.121457489878543 1.14162690562085 0.246998998815646 0.705696278128388 GO:0005315 phosphate transmembrane transporter activity 4/1983 24/18639 0.166666666666667 1.56656580937973 0.247962300079622 0.705696278128388 GO:0043998 histone H2A acetyltransferase activity 4/1983 24/18639 0.166666666666667 1.56656580937973 0.247962300079622 0.705696278128388 GO:0070300 phosphatidic acid binding 4/1983 24/18639 0.166666666666667 1.56656580937973 0.247962300079622 0.705696278128388 GO:0015144 carbohydrate transmembrane transporter activity 6/1983 40/18639 0.15 1.40990922844175 0.248530838385876 0.705739017688179 GO:0051059 NF-kappaB binding 5/1983 32/18639 0.15625 1.46865544629349 0.249902869056316 0.706580912369465 GO:0015294 solute:monoatomic cation symporter activity 15/1983 116/18639 0.129310344827586 1.215438990036 0.249935679591081 0.706580912369465 GO:0004601 peroxidase activity 8/1983 57/18639 0.140350877192982 1.31921331316188 0.256997165093271 0.722388942133288 GO:0005004 GPI-linked ephrin receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0005008 hepatocyte growth factor receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0005009 insulin receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0005011 macrophage colony-stimulating factor receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0005020 stem cell factor receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0008288 boss receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0035254 glutamate receptor binding 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0036332 placental growth factor receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0038062 protein tyrosine kinase collagen receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0060175 brain-derived neurotrophic factor receptor activity 7/1983 49/18639 0.142857142857143 1.34277069375405 0.262326337417814 0.722388942133288 GO:0016757 glycosyltransferase activity 32/1983 267/18639 0.119850187265918 1.12651923371126 0.262968776078546 0.722597391164109 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1983 17/18639 0.176470588235294 1.65871673934324 0.268368803963109 0.729539233829046 GO:0008429 phosphatidylethanolamine binding 3/1983 17/18639 0.176470588235294 1.65871673934324 0.268368803963109 0.729539233829046 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/1983 17/18639 0.176470588235294 1.65871673934324 0.268368803963109 0.729539233829046 GO:0045125 bioactive lipid receptor activity 3/1983 17/18639 0.176470588235294 1.65871673934324 0.268368803963109 0.729539233829046 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/1983 33/18639 0.151515151515152 1.42415073579975 0.270927266510146 0.729539233829046 GO:0016758 hexosyltransferase activity 24/1983 197/18639 0.121827411167513 1.14510394188163 0.271035761603644 0.729539233829046 GO:0004709 MAP kinase kinase kinase activity 4/1983 25/18639 0.16 1.50390317700454 0.272403446939556 0.729539233829046 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/1983 25/18639 0.16 1.50390317700454 0.272403446939556 0.729539233829046 GO:0051117 ATPase binding 11/1983 84/18639 0.130952380952381 1.23087313594121 0.278851170522038 0.729539233829046 GO:0005006 epidermal growth factor receptor activity 7/1983 50/18639 0.14 1.31591527987897 0.279453825481581 0.729539233829046 GO:0005007 fibroblast growth factor receptor activity 7/1983 50/18639 0.14 1.31591527987897 0.279453825481581 0.729539233829046 GO:0005017 platelet-derived growth factor receptor activity 7/1983 50/18639 0.14 1.31591527987897 0.279453825481581 0.729539233829046 GO:0005019 platelet-derived growth factor beta-receptor activity 7/1983 50/18639 0.14 1.31591527987897 0.279453825481581 0.729539233829046 GO:0050840 extracellular matrix binding 9/1983 67/18639 0.134328358208955 1.26260527920157 0.280681214010924 0.729539233829046 GO:0004402 histone acetyltransferase activity 6/1983 42/18639 0.142857142857143 1.34277069375405 0.286115053167255 0.729539233829046 GO:0042056 chemoattractant activity 6/1983 42/18639 0.142857142857143 1.34277069375405 0.286115053167255 0.729539233829046 GO:0017022 myosin binding 10/1983 76/18639 0.131578947368421 1.23676248108926 0.287016338172713 0.729539233829046 GO:0051536 iron-sulfur cluster binding 10/1983 76/18639 0.131578947368421 1.23676248108926 0.287016338172713 0.729539233829046 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0005345 purine nucleobase transmembrane transporter activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0005381 iron ion transmembrane transporter activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0005522 profilin binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0008140 cAMP response element binding protein binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0008239 dipeptidyl-peptidase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0015187 glycine transmembrane transporter activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0016783 sulfurtransferase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0031419 cobalamin binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0043422 protein kinase B binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0045322 unmethylated CpG binding 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0050308 sugar-phosphatase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0051864 histone H3K36 demethylase activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0141109 transporter activator activity 2/1983 10/18639 0.2 1.87987897125567 0.288722132875736 0.729539233829046 GO:0015020 glucuronosyltransferase activity 5/1983 34/18639 0.147058823529412 1.3822639494527 0.292308191959585 0.729539233829046 GO:0015035 protein-disulfide reductase activity 5/1983 34/18639 0.147058823529412 1.3822639494527 0.292308191959585 0.729539233829046 GO:0032934 sterol binding 9/1983 68/18639 0.132352941176471 1.24403755450743 0.295637545812774 0.729539233829046 GO:0005030 neurotrophin receptor activity 7/1983 51/18639 0.137254901960784 1.29011301948919 0.296847968596727 0.729539233829046 GO:0030544 Hsp70 protein binding 7/1983 51/18639 0.137254901960784 1.29011301948919 0.296847968596727 0.729539233829046 GO:0005112 Notch binding 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0005227 calcium-activated cation channel activity 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0008143 poly(A) binding 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0015216 purine nucleotide transmembrane transporter activity 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0030507 spectrin binding 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0050681 nuclear androgen receptor binding 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0070412 R-SMAD binding 4/1983 26/18639 0.153846153846154 1.44606074711975 0.297224602937425 0.729539233829046 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0015172 acidic amino acid transmembrane transporter activity 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0016854 racemase and epimerase activity 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0030228 lipoprotein particle receptor activity 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0070628 proteasome binding 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:1901611 phosphatidylglycerol binding 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:1990381 ubiquitin-specific protease binding 3/1983 18/18639 0.166666666666667 1.56656580937973 0.298681945144127 0.729539233829046 GO:0051540 metal cluster binding 10/1983 77/18639 0.12987012987013 1.2207006306855 0.301151768242272 0.731431895093036 GO:0005200 structural constituent of cytoskeleton 14/1983 112/18639 0.125 1.1749243570348 0.302516883501507 0.731431895093036 GO:0015108 chloride transmembrane transporter activity 15/1983 121/18639 0.12396694214876 1.16521423838162 0.304872408566516 0.731431895093036 GO:0008200 ion channel inhibitor activity 6/1983 43/18639 0.13953488372093 1.31154346831791 0.30534731528027 0.731431895093036 GO:0016791 phosphatase activity 32/1983 273/18639 0.117216117216117 1.10176056923409 0.306892891230665 0.731431895093036 GO:0030295 protein kinase activator activity 17/1983 139/18639 0.122302158273381 1.14956627738656 0.308478405475182 0.731431895093036 GO:0019209 kinase activator activity 18/1983 148/18639 0.121621621621622 1.1431696446825 0.309846576164475 0.731431895093036 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 15/1983 122/18639 0.122950819672131 1.15566330200144 0.316263447330876 0.731431895093036 GO:0019905 syntaxin binding 8/1983 61/18639 0.131147540983607 1.23270752213487 0.321114752004097 0.731431895093036 GO:0004896 cytokine receptor activity 12/1983 96/18639 0.125 1.1749243570348 0.322056579657814 0.731431895093036 GO:1901681 sulfur compound binding 32/1983 275/18639 0.116363636363636 1.09374776509421 0.322061172290265 0.731431895093036 GO:0016405 CoA-ligase activity 4/1983 27/18639 0.148148148148148 1.39250294167087 0.322300000989236 0.731431895093036 GO:0000287 magnesium ion binding 27/1983 230/18639 0.117391304347826 1.10340722225876 0.323114909481257 0.731431895093036 GO:0016248 channel inhibitor activity 6/1983 44/18639 0.136363636363636 1.28173566221978 0.324796463164955 0.731431895093036 GO:0016782 transferase activity, transferring sulphur-containing groups 9/1983 70/18639 0.128571428571429 1.20849362437865 0.326100276394665 0.731431895093036 GO:0003756 protein disulfide isomerase activity 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0008301 DNA binding, bending 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0043395 heparan sulfate proteoglycan binding 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0046527 glucosyltransferase activity 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0097001 ceramide binding 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:1990380 K48-linked deubiquitinase activity 3/1983 19/18639 0.157894736842105 1.48411497730711 0.329158079894811 0.731431895093036 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0002162 dystroglycan binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0004016 adenylate cyclase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0005225 volume-sensitive anion channel activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0008172 S-methyltransferase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0008199 ferric iron binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0008526 phosphatidylinositol transfer activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0010854 adenylate cyclase regulator activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0015205 nucleobase transmembrane transporter activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0015217 ADP transmembrane transporter activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0019107 myristoyltransferase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0019203 carbohydrate phosphatase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0019864 IgG binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0032050 clathrin heavy chain binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0032794 GTPase activating protein binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0034511 U3 snoRNA binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0035252 UDP-xylosyltransferase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0042285 xylosyltransferase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0043522 leucine zipper domain binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0050998 nitric-oxide synthase binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0070990 snRNP binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0097493 structural molecule activity conferring elasticity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0140031 phosphorylation-dependent protein binding 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0140537 transcription regulator activator activity 2/1983 11/18639 0.181818181818182 1.7089808829597 0.329861442885095 0.731431895093036 GO:0016860 intramolecular oxidoreductase activity 7/1983 53/18639 0.132075471698113 1.24142950931978 0.332264139510778 0.732935601862011 GO:0038064 collagen receptor activity 7/1983 53/18639 0.132075471698113 1.24142950931978 0.332264139510778 0.732935601862011 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/1983 53/18639 0.132075471698113 1.24142950931978 0.332264139510778 0.732935601862011 GO:0004033 aldo-keto reductase (NADPH) activity 5/1983 36/18639 0.138888888888889 1.30547150781644 0.335813938762285 0.739486652714876 GO:0008013 beta-catenin binding 13/1983 106/18639 0.122641509433962 1.1527559729398 0.336922432316591 0.740648450351128 GO:0035401 histone H3Y41 kinase activity 14/1983 115/18639 0.121739130434783 1.1442741564165 0.338303004318903 0.741127715647081 GO:0140801 histone H2AXY142 kinase activity 14/1983 115/18639 0.121739130434783 1.1442741564165 0.338303004318903 0.741127715647081 GO:0004674 protein serine/threonine kinase activity 49/1983 433/18639 0.113163972286374 1.06367285902457 0.344417543915506 0.753228762422418 GO:0008514 organic anion transmembrane transporter activity 31/1983 269/18639 0.115241635687732 1.08320163771238 0.345919870092113 0.755218894464803 GO:0046625 sphingolipid binding 4/1983 28/18639 0.142857142857143 1.34277069375405 0.347510294497201 0.757394231596463 GO:0015485 cholesterol binding 7/1983 54/18639 0.12962962962963 1.21844007396201 0.350200885690022 0.760657801115466 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/1983 54/18639 0.12962962962963 1.21844007396201 0.350200885690022 0.760657801115466 GO:0141108 transporter regulator activity 20/1983 170/18639 0.117647058823529 1.10581115956216 0.351508401393175 0.762199339755609 GO:0030971 receptor tyrosine kinase binding 10/1983 81/18639 0.123456790123457 1.16041911805906 0.359162605731532 0.775781686172557 GO:0001614 purinergic nucleotide receptor activity 3/1983 20/18639 0.15 1.40990922844175 0.359597628649397 0.775781686172557 GO:0016502 nucleotide receptor activity 3/1983 20/18639 0.15 1.40990922844175 0.359597628649397 0.775781686172557 GO:0004180 carboxypeptidase activity 6/1983 46/18639 0.130434782608696 1.22600802473196 0.364121481984913 0.777817667437749 GO:0019001 guanyl nucleotide binding 45/1983 400/18639 0.1125 1.05743192133132 0.368028022559301 0.777817667437749 GO:0032561 guanyl ribonucleotide binding 45/1983 400/18639 0.1125 1.05743192133132 0.368028022559301 0.777817667437749 GO:0000340 RNA 7-methylguanosine cap binding 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0004300 enoyl-CoA hydratase activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0005247 voltage-gated chloride channel activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0008504 monoamine transmembrane transporter activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0010853 cyclase activator activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0015132 prostaglandin transmembrane transporter activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0035251 UDP-glucosyltransferase activity 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0035259 nuclear glucocorticoid receptor binding 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0043047 single-stranded telomeric DNA binding 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0045295 gamma-catenin binding 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1983 12/18639 0.166666666666667 1.56656580937973 0.370302215007619 0.777817667437749 GO:0003785 actin monomer binding 4/1983 29/18639 0.137931034482759 1.2964682560384 0.372743399317974 0.780374111872606 GO:0106222 lncRNA binding 4/1983 29/18639 0.137931034482759 1.2964682560384 0.372743399317974 0.780374111872606 GO:0005109 frizzled binding 5/1983 38/18639 0.131578947368421 1.23676248108926 0.379793350674042 0.792531132748615 GO:0042162 telomeric DNA binding 5/1983 38/18639 0.131578947368421 1.23676248108926 0.379793350674042 0.792531132748615 GO:0061733 protein-lysine-acetyltransferase activity 6/1983 47/18639 0.127659574468085 1.19992274761 0.383889108401299 0.799768975836039 GO:0031490 chromatin DNA binding 15/1983 128/18639 0.1171875 1.10149158472012 0.386502955720043 0.8016514107674 GO:0031491 nucleosome binding 9/1983 74/18639 0.121621621621622 1.1431696446825 0.388465734227465 0.8016514107674 GO:0035064 methylated histone binding 9/1983 74/18639 0.121621621621622 1.1431696446825 0.388465734227465 0.8016514107674 GO:0043178 alcohol binding 11/1983 92/18639 0.119565217391304 1.12384068933763 0.388669056983924 0.8016514107674 GO:0005254 chloride channel activity 10/1983 83/18639 0.120481927710843 1.1324572115998 0.388733603786326 0.8016514107674 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/1983 21/18639 0.142857142857143 1.34277069375405 0.38982264680454 0.8016514107674 GO:0005248 voltage-gated sodium channel activity 3/1983 21/18639 0.142857142857143 1.34277069375405 0.38982264680454 0.8016514107674 GO:0072542 protein phosphatase activator activity 3/1983 21/18639 0.142857142857143 1.34277069375405 0.38982264680454 0.8016514107674 GO:0008187 poly-pyrimidine tract binding 4/1983 30/18639 0.133333333333333 1.25325264750378 0.397895098615196 0.812301520894231 GO:0015215 nucleotide transmembrane transporter activity 4/1983 30/18639 0.133333333333333 1.25325264750378 0.397895098615196 0.812301520894231 GO:0022839 monoatomic ion-gated channel activity 4/1983 30/18639 0.133333333333333 1.25325264750378 0.397895098615196 0.812301520894231 GO:0031210 phosphatidylcholine binding 4/1983 30/18639 0.133333333333333 1.25325264750378 0.397895098615196 0.812301520894231 GO:0004527 exonuclease activity 10/1983 84/18639 0.119047619047619 1.11897557812838 0.403582581254473 0.812301520894231 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/1983 48/18639 0.125 1.1749243570348 0.403657772735533 0.812301520894231 GO:0046982 protein heterodimerization activity 41/1983 369/18639 0.111111111111111 1.04437720625315 0.408158471317765 0.812301520894231 GO:0002161 aminoacyl-tRNA editing activity 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0009982 pseudouridine synthase activity 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0035325 Toll-like receptor binding 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0045159 myosin II binding 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0070123 transforming growth factor beta receptor activity, type III 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0140666 annealing activity 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0140852 histone ubiquitin ligase activity 2/1983 13/18639 0.153846153846154 1.44606074711975 0.40972751217165 0.812301520894231 GO:0016298 lipase activity 15/1983 130/18639 0.115384615384615 1.08454556033981 0.410364214558078 0.812301520894231 GO:0016798 hydrolase activity, acting on glycosyl bonds 15/1983 130/18639 0.115384615384615 1.08454556033981 0.410364214558078 0.812301520894231 GO:0016874 ligase activity 19/1983 167/18639 0.11377245508982 1.06939222915742 0.414456461285814 0.812301520894231 GO:0015291 secondary active transmembrane transporter activity 32/1983 287/18639 0.111498257839721 1.04801615122268 0.416825509386046 0.812301520894231 GO:0008970 phospholipase A1 activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0016881 acid-amino acid ligase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0032931 histone H3K56 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0043992 histone H3K9 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0043993 histone H3K18 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0043994 histone H3K23 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0043999 histone H2AK5 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044012 histone H2AK9 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044014 histone H2BK5 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044015 histone H2BK12 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044016 histone H3K4 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044017 histone H3K27 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0044018 histone H3K36 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0046972 histone H4K16 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0050321 tau-protein kinase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0061133 endopeptidase activator activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0140908 histone H3K122 acetyltransferase activity 3/1983 22/18639 0.136363636363636 1.28173566221978 0.419676497614934 0.812301520894231 GO:0140034 methylation-dependent protein binding 9/1983 76/18639 0.118421052631579 1.11308623298033 0.419942370787318 0.812301520894231 GO:0015276 ligand-gated monoatomic ion channel activity 21/1983 186/18639 0.112903225806452 1.0612219999024 0.420795558615439 0.812301520894231 GO:0016500 protein-hormone receptor activity 8/1983 67/18639 0.119402985074627 1.12231580373473 0.421323742731916 0.812301520894231 GO:0061980 regulatory RNA binding 7/1983 58/18639 0.120689655172414 1.1344097240336 0.422513181218015 0.812301520894231 GO:0016411 acylglycerol O-acyltransferase activity 4/1983 31/18639 0.129032258064516 1.2128251427456 0.422869439544186 0.812301520894231 GO:0016878 acid-thiol ligase activity 4/1983 31/18639 0.129032258064516 1.2128251427456 0.422869439544186 0.812301520894231 GO:0072349 modified amino acid transmembrane transporter activity 4/1983 31/18639 0.129032258064516 1.2128251427456 0.422869439544186 0.812301520894231 GO:0015036 disulfide oxidoreductase activity 5/1983 40/18639 0.125 1.1749243570348 0.423670989329148 0.812301520894231 GO:0032451 demethylase activity 5/1983 40/18639 0.125 1.1749243570348 0.423670989329148 0.812301520894231 GO:0008234 cysteine-type peptidase activity 21/1983 187/18639 0.112299465240642 1.0555470159457 0.430836238225529 0.821383785435716 GO:0016741 transferase activity, transferring one-carbon groups 24/1983 215/18639 0.111627906976744 1.04923477465433 0.433580213495318 0.821383785435716 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 15/1983 132/18639 0.113636363636364 1.06811305184981 0.434298731519762 0.821383785435716 GO:0004879 nuclear receptor activity 7/1983 59/18639 0.11864406779661 1.1151824405754 0.44053866539027 0.821383785435716 GO:0022834 ligand-gated channel activity 21/1983 188/18639 0.111702127659574 1.04993240415875 0.440883910342619 0.821383785435716 GO:0015605 organophosphate ester transmembrane transporter activity 6/1983 50/18639 0.12 1.1279273827534 0.443004521671492 0.821383785435716 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/1983 41/18639 0.121951219512195 1.1462676653998 0.445409049087649 0.821383785435716 GO:0017080 sodium channel regulator activity 5/1983 41/18639 0.121951219512195 1.1462676653998 0.445409049087649 0.821383785435716 GO:0140318 protein transporter activity 5/1983 41/18639 0.121951219512195 1.1462676653998 0.445409049087649 0.821383785435716 GO:0070717 poly-purine tract binding 4/1983 32/18639 0.125 1.1749243570348 0.447578949613881 0.821383785435716 GO:0005161 platelet-derived growth factor receptor binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0008494 translation activator activity 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0019763 immunoglobulin receptor activity 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0019992 diacylglycerol binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0031404 chloride ion binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0032454 histone H3K9 demethylase activity 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0034236 protein kinase A catalytic subunit binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0044548 S100 protein binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0046030 inositol trisphosphate phosphatase activity 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0070742 C2H2 zinc finger domain binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:1901612 cardiolipin binding 2/1983 14/18639 0.142857142857143 1.34277069375405 0.44789567731195 0.821383785435716 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0004602 glutathione peroxidase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0008171 O-methyltransferase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0017134 fibroblast growth factor binding 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0044013 histone H2B acetyltransferase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0071617 lysophospholipid acyltransferase activity 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0140103 catalytic activity, acting on a glycoprotein 3/1983 23/18639 0.130434782608696 1.22600802473196 0.449023136038192 0.821383785435716 GO:0001221 transcription coregulator binding 13/1983 115/18639 0.11304347826087 1.06254028810103 0.452351120799515 0.82628607309367 GO:0140996 histone H3 kinase activity 39/1983 357/18639 0.109243697478992 1.02682464816486 0.455560749659607 0.830958448949928 GO:0098531 ligand-modulated transcription factor activity 7/1983 60/18639 0.116666666666667 1.09659606656581 0.458470721783399 0.835071671819762 GO:0016830 carbon-carbon lyase activity 6/1983 51/18639 0.117647058823529 1.10581115956216 0.462492062081461 0.841194549434897 GO:0035198 miRNA binding 5/1983 42/18639 0.119047619047619 1.11897557812838 0.466935264752567 0.848066185982226 GO:0005525 GTP binding 41/1983 378/18639 0.108465608465608 1.01951108229474 0.472425803985894 0.855817994801896 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/1983 61/18639 0.114754098360656 1.07861908186801 0.476276125273308 0.855817994801896 GO:0035173 histone kinase activity 39/1983 360/18639 0.108333333333333 1.01826777609682 0.477567959146598 0.855817994801896 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0005540 hyaluronic acid binding 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0070840 dynein complex binding 3/1983 24/18639 0.125 1.1749243570348 0.477746112603701 0.855817994801896 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/1983 52/18639 0.115384615384615 1.08454556033981 0.481799848569763 0.855817994801896 GO:0005041 low-density lipoprotein particle receptor activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0031386 protein tag activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0051371 muscle alpha-actinin binding 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0120283 protein serine/threonine kinase binding 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0141047 molecular tag activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0141050 histone H3K deacetylase activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0141051 histone H4K deacetylase activity 2/1983 15/18639 0.133333333333333 1.25325264750378 0.484627915487819 0.855817994801896 GO:0003823 antigen binding 19/1983 174/18639 0.109195402298851 1.02637070269706 0.488388389136444 0.861265831464684 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 29/1983 268/18639 0.108208955223881 1.0170986971346 0.490801782063616 0.862945340951909 GO:0016831 carboxy-lyase activity 4/1983 34/18639 0.117647058823529 1.10581115956216 0.495896233280556 0.862945340951909 GO:0019825 oxygen binding 4/1983 34/18639 0.117647058823529 1.10581115956216 0.495896233280556 0.862945340951909 GO:0001217 DNA-binding transcription repressor activity 30/1983 278/18639 0.107913669064748 1.01432318592932 0.495971500976138 0.862945340951909 GO:0033192 calmodulin-dependent protein phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0140791 histone H2AXS140 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:1990439 MAP kinase serine/threonine phosphatase activity 9/1983 81/18639 0.111111111111111 1.04437720625315 0.497896618210635 0.862945340951909 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 14/1983 128/18639 0.109375 1.02805881240545 0.498526795671216 0.862945340951909 GO:0008146 sulfotransferase activity 6/1983 53/18639 0.113207547169811 1.06408243655981 0.500889513556016 0.862945340951909 GO:0034212 protein N-acetyltransferase activity 6/1983 53/18639 0.113207547169811 1.06408243655981 0.500889513556016 0.862945340951909 GO:0015085 calcium ion transmembrane transporter activity 16/1983 147/18639 0.108843537414966 1.02306338571737 0.500966510006711 0.862945340951909 GO:0043130 ubiquitin binding 11/1983 100/18639 0.11 1.03393343419062 0.500971944628166 0.862945340951909 GO:0141003 histone H2AX kinase activity 38/1983 354/18639 0.107344632768362 1.00897458909203 0.502452073625804 0.862945340951909 GO:0042379 chemokine receptor binding 8/1983 72/18639 0.111111111111111 1.04437720625315 0.504209673993864 0.862945340951909 GO:0005537 D-mannose binding 3/1983 25/18639 0.12 1.1279273827534 0.505747385194267 0.862945340951909 GO:0015645 fatty acid ligase activity 3/1983 25/18639 0.12 1.1279273827534 0.505747385194267 0.862945340951909 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/1983 25/18639 0.12 1.1279273827534 0.505747385194267 0.862945340951909 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/1983 25/18639 0.12 1.1279273827534 0.505747385194267 0.862945340951909 GO:0120515 fatty acid-CoA ligase activity 3/1983 25/18639 0.12 1.1279273827534 0.505747385194267 0.862945340951909 GO:0035591 signaling adaptor activity 14/1983 129/18639 0.108527131782946 1.02008936424726 0.510713851098477 0.862945340951909 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 9/1983 82/18639 0.109756097560976 1.03164089885982 0.513181451813823 0.862945340951909 GO:0033549 MAP kinase phosphatase activity 9/1983 82/18639 0.109756097560976 1.03164089885982 0.513181451813823 0.862945340951909 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 18/1983 167/18639 0.107784431137725 1.01310842762282 0.513821460040048 0.862945340951909 GO:0010485 histone H4 acetyltransferase activity 4/1983 35/18639 0.114285714285714 1.07421655500324 0.5193713988188 0.862945340951909 GO:0043015 gamma-tubulin binding 4/1983 35/18639 0.114285714285714 1.07421655500324 0.5193713988188 0.862945340951909 GO:0017069 snRNA binding 6/1983 54/18639 0.111111111111111 1.04437720625315 0.519725592039265 0.862945340951909 GO:0000062 fatty-acyl-CoA binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0003688 DNA replication origin binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0005521 lamin binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0008142 oxysterol binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0008296 3'-5'-DNA exonuclease activity 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0016722 oxidoreductase activity, acting on metal ions 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0030275 LRR domain binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0055102 lipase inhibitor activity 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0070411 I-SMAD binding 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0140328 floppase activity 2/1983 16/18639 0.125 1.1749243570348 0.519797664196915 0.862945340951909 GO:0005125 cytokine activity 25/1983 234/18639 0.106837606837607 1.00420885216649 0.5227223831239 0.866672351733384 GO:0008509 monoatomic anion transmembrane transporter activity 16/1983 149/18639 0.10738255033557 1.00933099127821 0.52365624396408 0.867093131239223 GO:0016247 channel regulator activity 18/1983 168/18639 0.107142857142857 1.00707802031554 0.524476839215683 0.867325512321654 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 9/1983 83/18639 0.108433734939759 1.01921149043982 0.528317000898249 0.870046301450442 GO:0015171 amino acid transmembrane transporter activity 11/1983 102/18639 0.107843137254902 1.01366022959865 0.5283866036411 0.870046301450442 GO:0004536 DNA nuclease activity 7/1983 64/18639 0.109375 1.02805881240545 0.528628497333655 0.870046301450442 GO:0004715 non-membrane spanning protein tyrosine kinase activity 5/1983 45/18639 0.111111111111111 1.04437720625315 0.529738031379931 0.870046301450442 GO:0140303 intramembrane lipid transporter activity 5/1983 45/18639 0.111111111111111 1.04437720625315 0.529738031379931 0.870046301450442 GO:0001637 G protein-coupled chemoattractant receptor activity 3/1983 26/18639 0.115384615384615 1.08454556033981 0.532946008966898 0.870046301450442 GO:0004112 cyclic-nucleotide phosphodiesterase activity 3/1983 26/18639 0.115384615384615 1.08454556033981 0.532946008966898 0.870046301450442 GO:0004529 DNA exonuclease activity 3/1983 26/18639 0.115384615384615 1.08454556033981 0.532946008966898 0.870046301450442 GO:0004950 chemokine receptor activity 3/1983 26/18639 0.115384615384615 1.08454556033981 0.532946008966898 0.870046301450442 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1983 26/18639 0.115384615384615 1.08454556033981 0.532946008966898 0.870046301450442 GO:0046943 carboxylic acid transmembrane transporter activity 20/1983 188/18639 0.106382978723404 0.999935623008337 0.535330882667769 0.872822091306145 GO:0008374 O-acyltransferase activity 6/1983 55/18639 0.109090909090909 1.02538852977582 0.538275550518277 0.87415044714346 GO:0099106 ion channel regulator activity 17/1983 160/18639 0.10625 0.998685703479576 0.540395501048364 0.87415044714346 GO:0004722 protein serine/threonine phosphatase activity 11/1983 103/18639 0.106796116504854 1.00381886814623 0.541911405437614 0.87415044714346 GO:0005253 monoatomic anion channel activity 11/1983 103/18639 0.106796116504854 1.00381886814623 0.541911405437614 0.87415044714346 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/1983 36/18639 0.111111111111111 1.04437720625315 0.542316081325864 0.87415044714346 GO:0055106 ubiquitin-protein transferase regulator activity 4/1983 36/18639 0.111111111111111 1.04437720625315 0.542316081325864 0.87415044714346 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1983 36/18639 0.111111111111111 1.04437720625315 0.542316081325864 0.87415044714346 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1983 36/18639 0.111111111111111 1.04437720625315 0.542316081325864 0.87415044714346 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1983 36/18639 0.111111111111111 1.04437720625315 0.542316081325864 0.87415044714346 GO:0017018 myosin phosphatase activity 9/1983 84/18639 0.107142857142857 1.00707802031554 0.543285131255502 0.87460674539238 GO:0005342 organic acid transmembrane transporter activity 20/1983 189/18639 0.105820105820106 0.994644958336335 0.545318902622089 0.876378792659396 GO:0019003 GDP binding 8/1983 75/18639 0.106666666666667 1.00260211800303 0.552160822455495 0.876378792659396 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0005092 GDP-dissociation inhibitor activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0016018 cyclosporin A binding 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0016805 dipeptidase activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0017110 nucleoside diphosphate phosphatase activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0032977 membrane insertase activity 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0048038 quinone binding 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0051787 misfolded protein binding 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:1901567 fatty acid derivative binding 2/1983 17/18639 0.117647058823529 1.10581115956216 0.553321512228089 0.876378792659396 GO:0030170 pyridoxal phosphate binding 6/1983 56/18639 0.107142857142857 1.00707802031554 0.556509788384562 0.879244089455163 GO:0170055 lipid transmembrane transporter activity 6/1983 56/18639 0.107142857142857 1.00707802031554 0.556509788384562 0.879244089455163 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1983 27/18639 0.111111111111111 1.04437720625315 0.559276759964106 0.881073443058725 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1983 27/18639 0.111111111111111 1.04437720625315 0.559276759964106 0.881073443058725 GO:0016829 lyase activity 21/1983 200/18639 0.105 0.986936459909228 0.559740775590249 0.881073443058725 GO:0019213 deacetylase activity 4/1983 37/18639 0.108108108108108 1.01615079527334 0.56468387549381 0.886066637879834 GO:0022829 wide pore channel activity 4/1983 37/18639 0.108108108108108 1.01615079527334 0.56468387549381 0.886066637879834 GO:0043495 protein-membrane adaptor activity 5/1983 47/18639 0.106382978723404 0.999935623008337 0.569702560020145 0.886066637879834 GO:0099095 ligand-gated monoatomic anion channel activity 5/1983 47/18639 0.106382978723404 0.999935623008337 0.569702560020145 0.886066637879834 GO:0140938 histone H3 methyltransferase activity 5/1983 47/18639 0.106382978723404 0.999935623008337 0.569702560020145 0.886066637879834 GO:0001664 G protein-coupled receptor binding 31/1983 297/18639 0.104377104377104 0.981081617995385 0.57335826592409 0.886066637879834 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/1983 57/18639 0.105263157894737 0.989409984871407 0.574401614694738 0.886066637879834 GO:0070279 vitamin B6 binding 6/1983 57/18639 0.105263157894737 0.989409984871407 0.574401614694738 0.886066637879834 GO:0008173 RNA methyltransferase activity 7/1983 67/18639 0.104477611940299 0.982026328267889 0.578830088830587 0.886066637879834 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1983 67/18639 0.104477611940299 0.982026328267889 0.578830088830587 0.886066637879834 GO:0042054 histone methyltransferase activity 7/1983 67/18639 0.104477611940299 0.982026328267889 0.578830088830587 0.886066637879834 GO:0015297 antiporter activity 14/1983 135/18639 0.103703703703704 0.974752059169608 0.581907187628913 0.886066637879834 GO:0015081 sodium ion transmembrane transporter activity 17/1983 164/18639 0.103658536585366 0.974327515589831 0.5830244371655 0.886066637879834 GO:0005242 inward rectifier potassium channel activity 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0016866 intramolecular transferase activity 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0036408 histone H3K14 acetyltransferase activity 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0050698 proteoglycan sulfotransferase activity 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0051393 alpha-actinin binding 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0051537 2 iron, 2 sulfur cluster binding 3/1983 28/18639 0.107142857142857 1.00707802031554 0.584688735820134 0.886066637879834 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0003746 translation elongation factor activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0004706 JUN kinase kinase kinase activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0004970 glutamate-gated receptor activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0008308 voltage-gated monoatomic anion channel activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0008409 5'-3' exonuclease activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0008525 phosphatidylcholine transporter activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0017075 syntaxin-1 binding 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0017128 phospholipid scramblase activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0022851 GABA-gated chloride ion channel activity 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0031690 adrenergic receptor binding 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0050811 GABA receptor binding 2/1983 18/18639 0.111111111111111 1.04437720625315 0.585151458113584 0.886066637879834 GO:0000146 microfilament motor activity 4/1983 38/18639 0.105263157894737 0.989409984871407 0.586435701943194 0.886957912191664 GO:0015631 tubulin binding 40/1983 385/18639 0.103896103896104 0.976560504548402 0.588578625856229 0.889144251145369 GO:0008408 3'-5' exonuclease activity 6/1983 58/18639 0.103448275862069 0.972351192028796 0.591927203172821 0.893144596503369 GO:0099094 ligand-gated monoatomic cation channel activity 14/1983 136/18639 0.102941176470588 0.967584764616891 0.593367507799994 0.894259541897155 GO:0015293 symporter activity 15/1983 146/18639 0.102739726027397 0.965691252357366 0.596957541242614 0.897061922731842 GO:0008168 methyltransferase activity 21/1983 204/18639 0.102941176470588 0.967584764616891 0.59762635376805 0.897061922731842 GO:0008170 N-methyltransferase activity 10/1983 98/18639 0.102040816326531 0.959121924110037 0.604209512937635 0.897061922731842 GO:0000217 DNA secondary structure binding 4/1983 39/18639 0.102564102564103 0.964040498079832 0.607539385541133 0.897061922731842 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1983 39/18639 0.102564102564103 0.964040498079832 0.607539385541133 0.897061922731842 GO:0005416 amino acid:monoatomic cation symporter activity 3/1983 29/18639 0.103448275862069 0.972351192028796 0.609143966954999 0.897061922731842 GO:0010484 histone H3 acetyltransferase activity 3/1983 29/18639 0.103448275862069 0.972351192028796 0.609143966954999 0.897061922731842 GO:0016279 protein-lysine N-methyltransferase activity 7/1983 69/18639 0.101449275362319 0.953561797013747 0.610811129619928 0.897061922731842 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0004890 GABA-A receptor activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0005520 insulin-like growth factor binding 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0008381 mechanosensitive monoatomic ion channel activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0015245 fatty acid transmembrane transporter activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0120227 acyl-CoA binding 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0141147 intracellularly calcium-gated channel activity 2/1983 19/18639 0.105263157894737 0.989409984871407 0.615268326139322 0.897061922731842 GO:0016278 lysine N-methyltransferase activity 7/1983 70/18639 0.1 0.939939485627837 0.626303501956987 0.897061922731842 GO:0004677 DNA-dependent protein kinase activity 25/1983 246/18639 0.101626016260163 0.955223054499834 0.627112901226757 0.897061922731842 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1983 40/18639 0.1 0.939939485627837 0.627969207342464 0.897061922731842 GO:0050997 quaternary ammonium group binding 4/1983 40/18639 0.1 0.939939485627837 0.627969207342464 0.897061922731842 GO:0001965 G-protein alpha-subunit binding 3/1983 30/18639 0.1 0.939939485627837 0.6326160634372 0.897061922731842 GO:0043995 histone H4K5 acetyltransferase activity 3/1983 30/18639 0.1 0.939939485627837 0.6326160634372 0.897061922731842 GO:0043996 histone H4K8 acetyltransferase activity 3/1983 30/18639 0.1 0.939939485627837 0.6326160634372 0.897061922731842 GO:0043997 histone H4K12 acetyltransferase activity 3/1983 30/18639 0.1 0.939939485627837 0.6326160634372 0.897061922731842 GO:0008017 microtubule binding 28/1983 276/18639 0.101449275362319 0.953561797013747 0.634754505563132 0.897061922731842 GO:0035403 histone H3T6 kinase activity 25/1983 247/18639 0.101214574898785 0.951355754684045 0.635356719780616 0.897061922731842 GO:0016836 hydro-lyase activity 6/1983 61/18639 0.0983606557377049 0.924530641601151 0.642109792750277 0.897061922731842 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0010851 cyclase regulator activity 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0016408 C-acyltransferase activity 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0052745 inositol phosphate phosphatase activity 2/1983 20/18639 0.1 0.939939485627837 0.643676181415981 0.897061922731842 GO:0004540 RNA nuclease activity 12/1983 121/18639 0.0991735537190083 0.932171390705293 0.645477059984878 0.897061922731842 GO:0005262 calcium channel activity 13/1983 131/18639 0.099236641221374 0.932764375050525 0.646930333391138 0.897061922731842 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1983 41/18639 0.0975609756097561 0.917014132319841 0.647705440667308 0.897061922731842 GO:0140828 metal cation:monoatomic cation antiporter activity 4/1983 41/18639 0.0975609756097561 0.917014132319841 0.647705440667308 0.897061922731842 GO:0005164 tumor necrosis factor receptor binding 3/1983 31/18639 0.0967741935483871 0.909618857059197 0.655088915997165 0.897061922731842 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/1983 31/18639 0.0967741935483871 0.909618857059197 0.655088915997165 0.897061922731842 GO:0005452 solute:inorganic anion antiporter activity 3/1983 31/18639 0.0967741935483871 0.909618857059197 0.655088915997165 0.897061922731842 GO:0008327 methyl-CpG binding 3/1983 31/18639 0.0967741935483871 0.909618857059197 0.655088915997165 0.897061922731842 GO:0047499 calcium-independent phospholipase A2 activity 3/1983 31/18639 0.0967741935483871 0.909618857059197 0.655088915997165 0.897061922731842 GO:0052689 carboxylic ester hydrolase activity 9/1983 92/18639 0.0978260869565217 0.919506018548971 0.655200591480811 0.897061922731842 GO:0030159 signaling receptor complex adaptor activity 5/1983 52/18639 0.0961538461538462 0.903787966949843 0.661182863281335 0.897061922731842 GO:0008307 structural constituent of muscle 4/1983 42/18639 0.0952380952380952 0.895180462502702 0.666733880237282 0.897061922731842 GO:0016859 cis-trans isomerase activity 4/1983 42/18639 0.0952380952380952 0.895180462502702 0.666733880237282 0.897061922731842 GO:0043175 RNA polymerase core enzyme binding 4/1983 42/18639 0.0952380952380952 0.895180462502702 0.666733880237282 0.897061922731842 GO:0048487 beta-tubulin binding 4/1983 42/18639 0.0952380952380952 0.895180462502702 0.666733880237282 0.897061922731842 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1983 21/18639 0.0952380952380952 0.895180462502702 0.670397606111922 0.897061922731842 GO:0009975 cyclase activity 2/1983 21/18639 0.0952380952380952 0.895180462502702 0.670397606111922 0.897061922731842 GO:0015125 bile acid transmembrane transporter activity 2/1983 21/18639 0.0952380952380952 0.895180462502702 0.670397606111922 0.897061922731842 GO:0005507 copper ion binding 6/1983 63/18639 0.0952380952380952 0.895180462502702 0.673418835428398 0.897061922731842 GO:0004090 carbonyl reductase (NADPH) activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0004935 adrenergic receptor activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0004955 prostaglandin receptor activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0005131 growth hormone receptor binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0005337 nucleoside transmembrane transporter activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0008519 ammonium channel activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0015203 polyamine transmembrane transporter activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0015279 store-operated calcium channel activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0015643 toxic substance binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0016868 intramolecular phosphotransferase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0019911 structural constituent of myelin sheath 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0032052 bile acid binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0043121 neurotrophin binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0043208 glycosphingolipid binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0043295 glutathione binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0050815 phosphoserine residue binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0051378 serotonin binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0071723 lipopeptide binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0097177 mitochondrial ribosome binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0098505 G-rich strand telomeric DNA binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0099122 RNA polymerase II C-terminal domain binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0140940 histone H2A methyltransferase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0140999 histone H3K4 trimethyltransferase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:1905394 retromer complex binding 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:1990259 histone H2AQ104 methyltransferase activity 1/1983 10/18639 0.1 0.939939485627837 0.675394285329999 0.897061922731842 GO:0022884 macromolecule transmembrane transporter activity 3/1983 32/18639 0.09375 0.881193267776097 0.676555464243712 0.897061922731842 GO:0047498 calcium-dependent phospholipase A2 activity 3/1983 32/18639 0.09375 0.881193267776097 0.676555464243712 0.897061922731842 GO:0005246 calcium channel regulator activity 5/1983 53/18639 0.0943396226415094 0.886735363799846 0.677880087211056 0.897061922731842 GO:0005544 calcium-dependent phospholipid binding 5/1983 53/18639 0.0943396226415094 0.886735363799846 0.677880087211056 0.897061922731842 GO:0003924 GTPase activity 33/1983 331/18639 0.0996978851963746 0.937099789296635 0.681076396479376 0.897061922731842 GO:0106310 protein serine kinase activity 36/1983 361/18639 0.0997229916897507 0.937335775141333 0.685980980016752 0.897061922731842 GO:0008276 protein methyltransferase activity 9/1983 95/18639 0.0947368421052632 0.890468986384266 0.692831481025048 0.897061922731842 GO:0003925 G protein activity 5/1983 54/18639 0.0925925925925926 0.870314338544293 0.694018301004095 0.897061922731842 GO:0004407 histone deacetylase activity 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0005243 gap junction channel activity 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0033558 protein lysine deacetylase activity 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0033691 sialic acid binding 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0034062 5'-3' RNA polymerase activity 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0097747 RNA polymerase activity 2/1983 22/18639 0.0909090909090909 0.854490441479852 0.69546971696162 0.897061922731842 GO:0004676 3-phosphoinositide-dependent protein kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0004711 ribosomal protein S6 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0035175 histone H3S10 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0035979 histone H2AXS139 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0044022 histone H3S28 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0044023 histone H4S1 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0044024 histone H2AS1 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0044025 histone H2BS14 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0072354 histone H3T3 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0072371 histone H2AS121 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0072518 Rho-dependent protein serine/threonine kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0140823 histone H2BS36 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0140855 histone H3S57 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0140995 histone H2A kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0140997 histone H4 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0140998 histone H2B kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:1990244 histone H2AT120 kinase activity 24/1983 245/18639 0.0979591836734694 0.920757047145636 0.696962582154829 0.897061922731842 GO:0019956 chemokine binding 3/1983 33/18639 0.0909090909090909 0.854490441479852 0.697016540767333 0.897061922731842 GO:0030296 protein tyrosine kinase activator activity 3/1983 33/18639 0.0909090909090909 0.854490441479852 0.697016540767333 0.897061922731842 GO:0071889 14-3-3 protein binding 3/1983 33/18639 0.0909090909090909 0.854490441479852 0.697016540767333 0.897061922731842 GO:0004252 serine-type endopeptidase activity 17/1983 176/18639 0.0965909090909091 0.907896094072342 0.69974099518401 0.897061922731842 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/1983 44/18639 0.0909090909090909 0.854490441479852 0.702635348737236 0.897061922731842 GO:0000149 SNARE binding 10/1983 106/18639 0.0943396226415094 0.886735363799846 0.702741948706773 0.897061922731842 GO:0019843 rRNA binding 6/1983 65/18639 0.0923076923076923 0.867636448271849 0.702915512221351 0.897061922731842 GO:0140857 histone H3T45 kinase activity 24/1983 246/18639 0.0975609756097561 0.917014132319841 0.704513899011918 0.897061922731842 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0004954 prostanoid receptor activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0008046 axon guidance receptor activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0008432 JUN kinase binding 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0008503 benzodiazepine receptor activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0019206 nucleoside kinase activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0034056 estrogen response element binding 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0047676 arachidonate-CoA ligase activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0050786 RAGE receptor binding 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0070697 activin receptor binding 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0180030 inositol phosphate kinase activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:1900750 oligopeptide binding 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:1990948 ubiquitin ligase inhibitor activity 1/1983 11/18639 0.0909090909090909 0.854490441479852 0.709947569574489 0.897061922731842 GO:0035402 histone H3T11 kinase activity 24/1983 247/18639 0.097165991902834 0.913301524496683 0.711956824130982 0.897061922731842 GO:0030332 cyclin binding 3/1983 34/18639 0.0882352941176471 0.829358369671621 0.716479796330569 0.897061922731842 GO:0005283 amino acid:sodium symporter activity 2/1983 23/18639 0.0869565217391304 0.81733868315464 0.718940819906709 0.897061922731842 GO:0016493 C-C chemokine receptor activity 2/1983 23/18639 0.0869565217391304 0.81733868315464 0.718940819906709 0.897061922731842 GO:0016849 phosphorus-oxygen lyase activity 2/1983 23/18639 0.0869565217391304 0.81733868315464 0.718940819906709 0.897061922731842 GO:0016917 GABA receptor activity 2/1983 23/18639 0.0869565217391304 0.81733868315464 0.718940819906709 0.897061922731842 GO:0031681 G-protein beta-subunit binding 2/1983 23/18639 0.0869565217391304 0.81733868315464 0.718940819906709 0.897061922731842 GO:0004679 AMP-activated protein kinase activity 24/1983 248/18639 0.0967741935483871 0.909618857059197 0.719289803812304 0.897061922731842 GO:0005496 steroid binding 10/1983 108/18639 0.0925925925925926 0.870314338544293 0.724787982547507 0.897061922731842 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/1983 229/18639 0.0960698689956332 0.902998632480891 0.725758841843085 0.897061922731842 GO:0070851 growth factor receptor binding 13/1983 139/18639 0.0935251798561151 0.879080094472077 0.728985512764981 0.897061922731842 GO:0004623 phospholipase A2 activity 3/1983 35/18639 0.0857142857142857 0.805662416252431 0.734958708597298 0.897061922731842 GO:0140566 histone reader activity 3/1983 35/18639 0.0857142857142857 0.805662416252431 0.734958708597298 0.897061922731842 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1983 46/18639 0.0869565217391304 0.81733868315464 0.73565273285596 0.897061922731842 GO:0003720 telomerase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0004000 adenosine deaminase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0004032 aldose reductase (NADPH) activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0004859 phospholipase inhibitor activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0005025 transforming growth factor beta receptor activity, type I 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0005026 transforming growth factor beta receptor activity, type II 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0005095 GTPase inhibitor activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0015166 polyol transmembrane transporter activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0015368 calcium:monoatomic cation antiporter activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016273 arginine N-methyltransferase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016274 protein-arginine N-methyltransferase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016361 activin receptor activity, type I 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016362 activin receptor activity, type II 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016423 tRNA (guanine) methyltransferase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0016840 carbon-nitrogen lyase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0017002 activin receptor activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0035197 siRNA binding 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0035497 cAMP response element binding 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0036009 protein-glutamine N-methyltransferase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0070410 co-SMAD binding 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0097371 MDM2/MDM4 family protein binding 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:1990817 poly(A) RNA polymerase activity 1/1983 12/18639 0.0833333333333333 0.783282904689864 0.740824419989659 0.897061922731842 GO:0004806 triacylglycerol lipase activity 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0019957 C-C chemokine binding 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0050699 WW domain binding 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/1983 24/18639 0.0833333333333333 0.783282904689864 0.74086761147971 0.897061922731842 GO:0000993 RNA polymerase II complex binding 3/1983 36/18639 0.0833333333333333 0.783282904689864 0.752471674712883 0.908524039070952 GO:0004190 aspartic-type endopeptidase activity 3/1983 36/18639 0.0833333333333333 0.783282904689864 0.752471674712883 0.908524039070952 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1983 36/18639 0.0833333333333333 0.783282904689864 0.752471674712883 0.908524039070952 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 23/1983 243/18639 0.0946502057613169 0.889654657178611 0.754401757448018 0.908737268462532 GO:0008080 N-acetyltransferase activity 6/1983 69/18639 0.0869565217391304 0.81733868315464 0.756331288597762 0.908737268462532 GO:0000049 tRNA binding 7/1983 80/18639 0.0875 0.822447049924357 0.760563442241749 0.908737268462532 GO:0000030 mannosyltransferase activity 2/1983 25/18639 0.08 0.751951588502269 0.761312848548009 0.908737268462532 GO:0003707 nuclear steroid receptor activity 2/1983 25/18639 0.08 0.751951588502269 0.761312848548009 0.908737268462532 GO:0017025 TBP-class protein binding 2/1983 25/18639 0.08 0.751951588502269 0.761312848548009 0.908737268462532 GO:0042974 nuclear retinoic acid receptor binding 2/1983 25/18639 0.08 0.751951588502269 0.761312848548009 0.908737268462532 GO:0008236 serine-type peptidase activity 18/1983 194/18639 0.0927835051546392 0.872108801097993 0.764526957180357 0.908737268462532 GO:0015459 potassium channel regulator activity 5/1983 59/18639 0.0847457627118644 0.796558886125285 0.76624177263295 0.908737268462532 GO:0003964 RNA-directed DNA polymerase activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0004465 lipoprotein lipase activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0004535 poly(A)-specific ribonuclease activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0004993 G protein-coupled serotonin receptor activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0019855 calcium channel inhibitor activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0031432 titin binding 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0031994 insulin-like growth factor I binding 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0061459 L-arginine transmembrane transporter activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0070700 BMP receptor binding 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:1901338 catecholamine binding 1/1983 13/18639 0.0769230769230769 0.723030373559874 0.768415828974493 0.908737268462532 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/1983 70/18639 0.0857142857142857 0.805662416252431 0.768521393595335 0.908737268462532 GO:0042805 actinin binding 3/1983 37/18639 0.0810810810810811 0.762113096455003 0.769041186408684 0.908737268462532 GO:0070001 aspartic-type peptidase activity 3/1983 37/18639 0.0810810810810811 0.762113096455003 0.769041186408684 0.908737268462532 GO:0015101 organic cation transmembrane transporter activity 7/1983 81/18639 0.0864197530864197 0.81229338264134 0.771824319752351 0.911181488596525 GO:0001098 basal transcription machinery binding 5/1983 60/18639 0.0833333333333333 0.783282904689864 0.779009362465595 0.913625214512584 GO:0001099 basal RNA polymerase II transcription machinery binding 5/1983 60/18639 0.0833333333333333 0.783282904689864 0.779009362465595 0.913625214512584 GO:0001222 transcription corepressor binding 4/1983 49/18639 0.0816326530612245 0.76729753928803 0.77986827975303 0.913625214512584 GO:0008066 glutamate receptor activity 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0019865 immunoglobulin binding 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0043548 phosphatidylinositol 3-kinase binding 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0051139 metal cation:proton antiporter activity 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0097602 cullin family protein binding 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0120014 phospholipid transfer activity 2/1983 26/18639 0.0769230769230769 0.723030373559874 0.780343418513102 0.913625214512584 GO:0017171 serine hydrolase activity 18/1983 198/18639 0.0909090909090909 0.854490441479852 0.793010907408912 0.916741443519211 GO:0005313 L-glutamate transmembrane transporter activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0008174 mRNA methyltransferase activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0008331 high voltage-gated calcium channel activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0015386 potassium:proton antiporter activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0015926 glucosidase activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0016530 metallochaperone activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0043176 amine binding 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0098599 palmitoyl hydrolase activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0098821 BMP receptor activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:1901474 azole transmembrane transporter activity 1/1983 14/18639 0.0714285714285714 0.671385346877026 0.793071225256228 0.916741443519211 GO:0046873 metal ion transmembrane transporter activity 43/1983 450/18639 0.0955555555555556 0.898164397377711 0.795630937285534 0.918867250941173 GO:0008266 poly(U) RNA binding 2/1983 27/18639 0.0740740740740741 0.696251470835434 0.798028751197021 0.919138805579225 GO:0008320 protein transmembrane transporter activity 2/1983 27/18639 0.0740740740740741 0.696251470835434 0.798028751197021 0.919138805579225 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1983 27/18639 0.0740740740740741 0.696251470835434 0.798028751197021 0.919138805579225 GO:0003684 damaged DNA binding 6/1983 74/18639 0.0810810810810811 0.762113096455003 0.812738071966989 0.925428481794834 GO:0030331 nuclear estrogen receptor binding 3/1983 40/18639 0.075 0.704954614220877 0.813360219266095 0.925428481794834 GO:0061791 GTPase motor activity 3/1983 40/18639 0.075 0.704954614220877 0.813360219266095 0.925428481794834 GO:1990606 membrane scission GTPase motor activity 3/1983 40/18639 0.075 0.704954614220877 0.813360219266095 0.925428481794834 GO:0051019 mitogen-activated protein kinase binding 2/1983 28/18639 0.0714285714285714 0.671385346877026 0.814439521610628 0.925428481794834 GO:0004089 carbonate dehydratase activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0004953 icosanoid receptor activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0015116 sulfate transmembrane transporter activity 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0030553 cGMP binding 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0031005 filamin binding 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0033130 acetylcholine receptor binding 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0045504 dynein heavy chain binding 1/1983 15/18639 0.0666666666666667 0.626626323751891 0.815102890239685 0.925428481794834 GO:0140767 enzyme-substrate adaptor activity 12/1983 139/18639 0.0863309352517986 0.811458548743456 0.816625132744643 0.926331889901619 GO:0050660 flavin adenine dinucleotide binding 7/1983 86/18639 0.0813953488372093 0.765067023185449 0.82230023285059 0.931940263897336 GO:0008227 G protein-coupled amine receptor activity 3/1983 41/18639 0.0731707317073171 0.68776059923988 0.826438228102841 0.935798171253217 GO:0004181 metallocarboxypeptidase activity 2/1983 29/18639 0.0689655172413793 0.648234128019198 0.829646599733267 0.936105676690191 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1983 29/18639 0.0689655172413793 0.648234128019198 0.829646599733267 0.936105676690191 GO:0043236 laminin binding 2/1983 29/18639 0.0689655172413793 0.648234128019198 0.829646599733267 0.936105676690191 GO:0097472 cyclin-dependent protein kinase activity 2/1983 29/18639 0.0689655172413793 0.648234128019198 0.829646599733267 0.936105676690191 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0004708 MAP kinase kinase activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0015378 sodium:chloride symporter activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0015385 sodium:proton antiporter activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0022841 potassium ion leak channel activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0097027 ubiquitin-protein transferase activator activity 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1983 16/18639 0.0625 0.587462178517398 0.834789905309203 0.936110052127735 GO:0022836 gated channel activity 29/1983 318/18639 0.0911949685534591 0.857177518339851 0.835913750896043 0.936546601399345 GO:0004520 DNA endonuclease activity 3/1983 42/18639 0.0714285714285714 0.671385346877026 0.838723177938653 0.937223533629959 GO:0019894 kinesin binding 3/1983 42/18639 0.0714285714285714 0.671385346877026 0.838723177938653 0.937223533629959 GO:0031492 nucleosomal DNA binding 3/1983 42/18639 0.0714285714285714 0.671385346877026 0.838723177938653 0.937223533629959 GO:0016769 transferase activity, transferring nitrogenous groups 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:0031624 ubiquitin conjugating enzyme binding 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:0033612 receptor serine/threonine kinase binding 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:0051721 protein phosphatase 2A binding 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:0070566 adenylyltransferase activity 2/1983 30/18639 0.0666666666666667 0.626626323751891 0.8437202094687 0.937875559784301 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 10/1983 122/18639 0.0819672131147541 0.770442201334292 0.84836139728362 0.940940815448386 GO:0005245 voltage-gated calcium channel activity 3/1983 43/18639 0.0697674418604651 0.655771734158956 0.850249013395597 0.940940815448386 GO:0004659 prenyltransferase activity 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0008569 minus-end-directed microtubule motor activity 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0030548 acetylcholine receptor regulator activity 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0036041 long-chain fatty acid binding 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0046965 nuclear retinoid X receptor binding 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0070402 NADPH binding 1/1983 17/18639 0.0588235294117647 0.55290557978108 0.852381679876773 0.940940815448386 GO:0043021 ribonucleoprotein complex binding 15/1983 177/18639 0.0847457627118644 0.796558886125285 0.856973677283968 0.945191555827906 GO:0016835 carbon-oxygen lyase activity 6/1983 79/18639 0.0759493670886076 0.713878090350256 0.858346107284902 0.945887024017502 GO:0001046 core promoter sequence-specific DNA binding 3/1983 44/18639 0.0681818181818182 0.640867831109889 0.861050013248648 0.946412730079332 GO:0001223 transcription coactivator binding 3/1983 44/18639 0.0681818181818182 0.640867831109889 0.861050013248648 0.946412730079332 GO:0043014 alpha-tubulin binding 3/1983 44/18639 0.0681818181818182 0.640867831109889 0.861050013248648 0.946412730079332 GO:0005548 phospholipid transporter activity 5/1983 68/18639 0.0735294117647059 0.69113197472635 0.862482253468699 0.947170433395858 GO:0000400 four-way junction DNA binding 1/1983 18/18639 0.0555555555555556 0.522188603126576 0.868101104686372 0.948325843183968 GO:0015280 ligand-gated sodium channel activity 1/1983 18/18639 0.0555555555555556 0.522188603126576 0.868101104686372 0.948325843183968 GO:0015373 monoatomic anion:sodium symporter activity 1/1983 18/18639 0.0555555555555556 0.522188603126576 0.868101104686372 0.948325843183968 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1983 18/18639 0.0555555555555556 0.522188603126576 0.868101104686372 0.948325843183968 GO:0099602 neurotransmitter receptor regulator activity 1/1983 18/18639 0.0555555555555556 0.522188603126576 0.868101104686372 0.948325843183968 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1983 32/18639 0.0625 0.587462178517398 0.868740850854019 0.948325843183968 GO:0043425 bHLH transcription factor binding 2/1983 32/18639 0.0625 0.587462178517398 0.868740850854019 0.948325843183968 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1983 46/18639 0.0652173913043478 0.61300401236598 0.880614516437651 0.952360624009772 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0008574 plus-end-directed microtubule motor activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0022821 solute:potassium antiporter activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0022840 leak channel activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0022842 narrow pore channel activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0030506 ankyrin binding 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0042577 lipid phosphatase activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0042800 histone H3K4 methyltransferase activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0042834 peptidoglycan binding 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0070003 threonine-type peptidase activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0099589 serotonin receptor activity 1/1983 19/18639 0.0526315789473684 0.494704992435703 0.882147370161209 0.952360624009772 GO:0016410 N-acyltransferase activity 7/1983 94/18639 0.074468085106383 0.699954936105836 0.884350228382081 0.953602062046589 GO:0140101 catalytic activity, acting on a tRNA 11/1983 139/18639 0.079136690647482 0.743837003014835 0.885492175022969 0.953602062046589 GO:0070888 E-box binding 4/1983 59/18639 0.0677966101694915 0.637247108900228 0.886111312345202 0.953602062046589 GO:0004497 monooxygenase activity 8/1983 106/18639 0.0754716981132075 0.709388291039877 0.888181022810917 0.953602062046589 GO:0005504 fatty acid binding 3/1983 47/18639 0.0638297872340425 0.599961373805002 0.889445736315034 0.953602062046589 GO:0008175 tRNA methyltransferase activity 2/1983 34/18639 0.0588235294117647 0.55290557978108 0.890028591243484 0.953602062046589 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1983 34/18639 0.0588235294117647 0.55290557978108 0.890028591243484 0.953602062046589 GO:0051427 hormone receptor binding 2/1983 34/18639 0.0588235294117647 0.55290557978108 0.890028591243484 0.953602062046589 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/1983 34/18639 0.0588235294117647 0.55290557978108 0.890028591243484 0.953602062046589 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1983 60/18639 0.0666666666666667 0.626626323751891 0.893761451622317 0.953796462234001 GO:0005326 neurotransmitter transmembrane transporter activity 1/1983 20/18639 0.05 0.469969742813918 0.894698485358326 0.953796462234001 GO:0030742 GTP-dependent protein binding 1/1983 20/18639 0.05 0.469969742813918 0.894698485358326 0.953796462234001 GO:0061608 nuclear import signal receptor activity 1/1983 20/18639 0.05 0.469969742813918 0.894698485358326 0.953796462234001 GO:0140664 ATP-dependent DNA damage sensor activity 1/1983 20/18639 0.05 0.469969742813918 0.894698485358326 0.953796462234001 GO:0140939 histone H4 methyltransferase activity 1/1983 20/18639 0.05 0.469969742813918 0.894698485358326 0.953796462234001 GO:0046906 tetrapyrrole binding 12/1983 152/18639 0.0789473684210526 0.742057488653555 0.895552742453547 0.953909562763803 GO:0016407 acetyltransferase activity 7/1983 96/18639 0.0729166666666667 0.685372541603631 0.896668399368103 0.954300675454367 GO:0005343 organic acid:sodium symporter activity 2/1983 35/18639 0.0571428571428571 0.537108277501621 0.899426765949313 0.954926189658363 GO:0016229 steroid dehydrogenase activity 2/1983 35/18639 0.0571428571428571 0.537108277501621 0.899426765949313 0.954926189658363 GO:0004843 cysteine-type deubiquitinase activity 8/1983 108/18639 0.0740740740740741 0.696251470835434 0.899572844427567 0.954926189658363 GO:0003774 cytoskeletal motor activity 12/1983 153/18639 0.0784313725490196 0.737207439708107 0.900251984289688 0.954926189658363 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1983 21/18639 0.0476190476190476 0.447590231251351 0.905913529320646 0.956950911254203 GO:0008373 sialyltransferase activity 1/1983 21/18639 0.0476190476190476 0.447590231251351 0.905913529320646 0.956950911254203 GO:0015174 basic amino acid transmembrane transporter activity 1/1983 21/18639 0.0476190476190476 0.447590231251351 0.905913529320646 0.956950911254203 GO:0035613 RNA stem-loop binding 1/1983 21/18639 0.0476190476190476 0.447590231251351 0.905913529320646 0.956950911254203 GO:0051428 peptide hormone receptor binding 1/1983 21/18639 0.0476190476190476 0.447590231251351 0.905913529320646 0.956950911254203 GO:0022824 transmitter-gated monoatomic ion channel activity 4/1983 63/18639 0.0634920634920635 0.596786975001801 0.914065535396728 0.963964894649155 GO:0022835 transmitter-gated channel activity 4/1983 63/18639 0.0634920634920635 0.596786975001801 0.914065535396728 0.963964894649155 GO:0005048 signal sequence binding 3/1983 51/18639 0.0588235294117647 0.55290557978108 0.919190248959225 0.968026744925809 GO:0043022 ribosome binding 8/1983 112/18639 0.0714285714285714 0.671385346877026 0.919435598513847 0.968026744925809 GO:0005212 structural constituent of eye lens 1/1983 23/18639 0.0434782608695652 0.40866934157732 0.924888928848677 0.972859221376505 GO:0160215 deacylase activity 4/1983 65/18639 0.0615384615384615 0.578424298847899 0.925603309745562 0.972859221376505 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1983 39/18639 0.0512820512820513 0.482020249039916 0.930006353560346 0.972859221376505 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1983 53/18639 0.0566037735849057 0.532041218279907 0.931141734758608 0.972859221376505 GO:0017046 peptide hormone binding 3/1983 53/18639 0.0566037735849057 0.532041218279907 0.931141734758608 0.972859221376505 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1983 53/18639 0.0566037735849057 0.532041218279907 0.931141734758608 0.972859221376505 GO:0101005 deubiquitinase activity 8/1983 115/18639 0.0695652173913043 0.653870946523712 0.932022887624954 0.972859221376505 GO:0015370 solute:sodium symporter activity 5/1983 79/18639 0.0632911392405063 0.594898408625213 0.932739280700619 0.972859221376505 GO:0033293 monocarboxylic acid binding 5/1983 79/18639 0.0632911392405063 0.594898408625213 0.932739280700619 0.972859221376505 GO:0030552 cAMP binding 1/1983 24/18639 0.0416666666666667 0.391641452344932 0.932889855690806 0.972859221376505 GO:0140612 DNA damage sensor activity 1/1983 24/18639 0.0416666666666667 0.391641452344932 0.932889855690806 0.972859221376505 GO:0019783 ubiquitin-like protein peptidase activity 9/1983 127/18639 0.0708661417322835 0.666098848082719 0.93318182568115 0.972859221376505 GO:0071855 neuropeptide receptor binding 2/1983 40/18639 0.05 0.469969742813918 0.936145623786359 0.97385145677147 GO:0050661 NADP binding 3/1983 54/18639 0.0555555555555556 0.522188603126576 0.936486661596948 0.97385145677147 GO:0008139 nuclear localization sequence binding 1/1983 25/18639 0.04 0.375975794251135 0.940038897655089 0.97385145677147 GO:0008483 transaminase activity 1/1983 25/18639 0.04 0.375975794251135 0.940038897655089 0.97385145677147 GO:0017056 structural constituent of nuclear pore 1/1983 25/18639 0.04 0.375975794251135 0.940038897655089 0.97385145677147 GO:0022832 voltage-gated channel activity 13/1983 175/18639 0.0742857142857143 0.698240760752107 0.940270356278202 0.97385145677147 GO:0003777 microtubule motor activity 4/1983 68/18639 0.0588235294117647 0.55290557978108 0.940304447783147 0.97385145677147 GO:0140223 general transcription initiation factor activity 4/1983 68/18639 0.0588235294117647 0.55290557978108 0.940304447783147 0.97385145677147 GO:0004812 aminoacyl-tRNA ligase activity 2/1983 41/18639 0.0487804878048781 0.45850706615992 0.941771644077822 0.97385145677147 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/1983 41/18639 0.0487804878048781 0.45850706615992 0.941771644077822 0.97385145677147 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1983 130/18639 0.0692307692307692 0.650727336203887 0.943433682536965 0.97405323076747 GO:0042562 hormone binding 6/1983 94/18639 0.0638297872340425 0.599961373805002 0.94349469803751 0.97405323076747 GO:0020037 heme binding 10/1983 142/18639 0.0704225352112676 0.661929215230871 0.944373497565241 0.974171690449582 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/1983 56/18639 0.0535714285714286 0.50353901015777 0.946043824574275 0.975105801400323 GO:0051879 Hsp90 protein binding 2/1983 42/18639 0.0476190476190476 0.447590231251351 0.94692406738478 0.975224705909204 GO:0005179 hormone activity 9/1983 132/18639 0.0681818181818182 0.640867831109889 0.949476043562334 0.977063725215477 GO:0008395 steroid hydroxylase activity 1/1983 27/18639 0.037037037037037 0.348125735417717 0.95213433088322 0.978220202962213 GO:0015252 proton channel activity 1/1983 27/18639 0.037037037037037 0.348125735417717 0.95213433088322 0.978220202962213 GO:0030527 structural constituent of chromatin 6/1983 98/18639 0.0612244897959184 0.575473154466022 0.956564239863744 0.981877334479826 GO:0008527 taste receptor activity 1/1983 28/18639 0.0357142857142857 0.335692673438513 0.957234138634057 0.981877334479826 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1983 73/18639 0.0547945205479452 0.515035334590595 0.959034138240019 0.982932898919633 GO:0005216 monoatomic ion channel activity 37/1983 448/18639 0.0825892857142857 0.776289307326561 0.96210940821957 0.985292767453776 GO:0005244 voltage-gated monoatomic ion channel activity 12/1983 173/18639 0.069364161849711 0.651981146100233 0.963116163789565 0.985532190073592 GO:0098918 structural constituent of synapse 1/1983 30/18639 0.0333333333333333 0.313313161875945 0.965862237382399 0.987549601172862 GO:0015106 bicarbonate transmembrane transporter activity 1/1983 32/18639 0.03125 0.293731089258699 0.97275029839098 0.992999704122097 GO:0140142 nucleocytoplasmic carrier activity 1/1983 32/18639 0.03125 0.293731089258699 0.97275029839098 0.992999704122097 GO:0019239 deaminase activity 1/1983 33/18639 0.0303030303030303 0.284830147159951 0.9756543752594 0.994371965192434 GO:0042923 neuropeptide binding 1/1983 33/18639 0.0303030303030303 0.284830147159951 0.9756543752594 0.994371965192434 GO:0016597 amino acid binding 2/1983 51/18639 0.0392156862745098 0.368603719854054 0.977318858275092 0.995272798962255 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1983 34/18639 0.0294117647058824 0.27645278989054 0.978249095987155 0.995425057768254 GO:0015079 potassium ion transmembrane transporter activity 10/1983 160/18639 0.0625 0.587462178517398 0.980117686505829 0.995917621915362 GO:0000175 3'-5'-RNA exonuclease activity 1/1983 35/18639 0.0285714285714286 0.26855413875081 0.980567399811797 0.995917621915362 GO:0030594 neurotransmitter receptor activity 5/1983 97/18639 0.0515463917525773 0.484504889498885 0.981536933407423 0.995917621915362 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1983 69/18639 0.0434782608695652 0.40866934157732 0.98206545193394 0.995917621915362 GO:0005484 SNAP receptor activity 1/1983 36/18639 0.0277777777777778 0.261094301563288 0.982638720289824 0.995917621915362 GO:0030280 structural constituent of skin epidermis 1/1983 37/18639 0.027027027027027 0.254037698818334 0.98448935823345 0.996209469640991 GO:0030551 cyclic nucleotide binding 1/1983 37/18639 0.027027027027027 0.254037698818334 0.98448935823345 0.996209469640991 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/1983 38/18639 0.0263157894736842 0.247352496217852 0.986142814992028 0.997091268132304 GO:0004532 RNA exonuclease activity 1/1983 40/18639 0.025 0.234984871406959 0.988939948408413 0.998336052431296 GO:0071949 FAD binding 1/1983 40/18639 0.025 0.234984871406959 0.988939948408413 0.998336052431296 GO:0005261 monoatomic cation channel activity 24/1983 341/18639 0.0703812316715543 0.661540986952143 0.99128910721437 0.999915832039812 GO:0016790 thiolester hydrolase activity 1/1983 44/18639 0.0227272727272727 0.213622610369963 0.992954886620173 0.999999999999322 GO:0005249 voltage-gated potassium channel activity 4/1983 98/18639 0.0408163265306122 0.383648769644015 0.99459459396777 0.999999999999322 GO:0022843 voltage-gated monoatomic cation channel activity 7/1983 143/18639 0.048951048951049 0.46011023771992 0.995380709918349 0.999999999999322 GO:0008188 neuropeptide receptor activity 1/1983 48/18639 0.0208333333333333 0.195820726172466 0.995512812515638 0.999999999999322 GO:0005267 potassium channel activity 5/1983 124/18639 0.0403225806451613 0.379007857107999 0.997836303938366 0.999999999999322 GO:0003735 structural constituent of ribosome 7/1983 175/18639 0.04 0.375975794251135 0.999610639532872 0.999999999999322 GO:0003730 mRNA 3'-UTR binding 11/1983 262/18639 0.0419847328244275 0.394631081752145 0.999957209645918 0.999999999999322 GO:0008528 G protein-coupled peptide receptor activity 2/1983 122/18639 0.0163934426229508 0.154088440266858 0.999983651064333 0.999999999999322 GO:0001653 peptide receptor activity 2/1983 128/18639 0.015625 0.146865544629349 0.999991330682375 0.999999999999322 GO:0045182 translation regulator activity 8/1983 356/18639 0.0224719101123595 0.211222356320862 0.999999999830347 0.999999999999322 GO:0030371 translation repressor activity 4/1983 329/18639 0.0121580547112462 0.114278356915238 0.999999999999322 0.999999999999322