category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	37/1293	82/9376	3.27195216267708	B2M/HSPA1A/HLA-A/HLA-B/HLA-DRA/HSPA1B/CD74/HSP90AA1/IFI30/HLA-E/HLA-C/LGMN/CTSL/HLA-G/HSPA4/HLA-DRB1/CTSB/HLA-DPB1/NFYB/CTSS/NFYC/CANX/TAPBP/HLA-DPA1/PSME1/CREB1/PDIA3/TNF/HLA-DMA/HSPA6/PSME2/CD4/HLA-DRB5/HLA-DQA1/HLA-DMB/HLA-F/TAPBPL	8.26424885268767
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	58/1293	174/9376	2.41711781386955	HSPA1A/HSPA1B/MAN1A2/HSP90AA1/SIL1/SSR1/TRAM1/SAR1A/DNAJB11/DNAJC3/VCP/TUSC3/MBTPS1/NGLY1/MAN1B1/RPN2/OS9/ATF6/UBE2D3/UBQLN1/PLAA/DDOST/CANX/PRKCSH/FBXO6/DNAJB12/SEL1L/PREB/BAX/SEC23B/UBE4B/CKAP4/NPLOC4/UBE2G2/SEC23A/CUL1/PDIA3/STT3A/SKP1/UBXN8/SEC24B/HERPUD1/RNF185/SYVN1/NFE2L2/RRBP1/PDIA4/HSPA6/STT3B/XBP1/P4HB/DNAJC10/MAP2K7/DNAJC5/MAN1A1/DNAJB1/PPP1R15A/BCAP29	7.54636971073595
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	65/1293	224/9376	2.10418738260966	B2M/FOS/HLA-A/HLA-B/NFKBIA/HLA-DRA/JUN/VDAC3/HLA-E/HLA-C/TNFRSF1A/EGR1/KAT5/HLA-G/TGFBR2/SLC25A6/LTBR/XPO1/HLA-DRB1/MAPK3/SLC25A5/ZFP36/HLA-DPB1/NFYB/CANX/PIK3R1/NRAS/DLG1/HLA-DPA1/VAC14/CREB1/ICAM1/RANBP3/MAPK1/BAX/ITGB2/POLB/AKT2/CDC23/ANAPC4/SPI1/TBP/ANAPC7/JAK1/TLN2/TNF/HLA-DMA/ELK4/PIK3CA/CDK2/TCF3/CD4/IKBKG/IL1R2/CREB3L2/MAP2K1/HLA-DRB5/HLA-DQA1/TGFBR1/HLA-DMB/ADCY7/GPS2/NRP1/ATF2/HLA-F	6.68971159357919
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	52/1293	169/9376	2.23118567434113	GABARAPL1/RPS6KB2/ATG3/DAPK1/BECN1/RAB1A/LAMP2/RB1CC1/CTSL/ATG12/RAB8A/UBC/RHEB/WIPI2/MAP1LC3B/MAPK3/CTSB/BIRC6/WIPI1/PIK3R1/NRAS/NBR1/HIF1A/IGF1R/PRKAA1/STK11/VPS16/MAPK1/ATG4B/ULK1/SNAP29/DAPK3/RPS6KB1/UVRAG/AKT2/CFLAR/CAMKK2/DDIT4/ATG13/ATG4D/SQSTM1/ATG4A/PIK3C3/IRS2/TANK/PIK3CA/ATG16L2/MAP3K7/MTMR14/WDR45B/VMP1/MAP2K1	6.4596121914251
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	68/1293	250/9376	1.97236813611756	LGMN/ARL8B/LAMP2/CTSL/ATP6V0C/AP2M1/ACP2/AP3B1/ATP6V0B/GNPTG/PSAP/ARL8A/HEXB/LAMTOR3/M6PR/ATP6V0D1/SCARB2/AP2B1/CTSB/AGA/BORCS6/DNASE2/CTSS/ROGDI/LAPTM5/FUCA1/ATP6V1H/AP1G2/OSBPL2/VPS26B/PPT1/AP3D1/VPS16/ARSA/CLTC/CTBS/GUSB/SNAP29/CD68/GNPTAB/SLC17A5/ATP6V1C1/NCOA7/OSBPL3/ABCA5/GALNS/LITAF/VPS13C/AP1M1/NAGLU/ATP6V1A/NEU1/HGSNAT/MFSD8/VAMP7/AP1G1/TFE3/MAN2B1/CTSC/SLC15A4/HEXA/DMXL1/TCIRG1/NAGA/AP3M2/ENTPD4/TELO2/SLC15A3	6.23245429316876
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	40/1293	119/9376	2.43742972827182	FOS/NFKBIA/JUN/JUNB/TNFRSF1A/CYLD/DNM1L/CXCL2/MAPK3/CCL2/RPS6KA4/PIK3R1/TAB2/CREB1/IL1B/RHBDF1/BIRC2/CXCL3/ICAM1/MAPK1/TAB3/AKT2/SOCS3/CFLAR/CCL5/IRF1/RPS6KA5/TNF/PIK3CA/MAP3K7/TNFRSF1B/CEBPB/MAP2K7/PTGS2/IKBKG/TNFAIP3/CREB3L2/MAP2K1/CXCL1/ATF2	6.31136914858468
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	53/1293	180/9376	2.13512073558477	B2M/HLA-A/HLA-B/NFKBIA/HLA-DRA/CD74/HLA-E/HLA-C/TNFRSF1A/CYCS/EIF4EBP1/HLA-G/ITGA5/RHEB/HLA-DRB1/HLA-DPB1/CCL2/EIF2B4/PIK3R1/EIF2B5/TAPBP/TAB2/IFIH1/HLA-DPA1/IL1B/BIRC2/BAX/IRAK1/AKT2/IFNGR2/SOCS3/SRSF7/IRF3/EIF2AK2/PDIA3/CCL5/TNFRSF14/JAK1/TNF/HLA-DMA/CASP9/PIK3CA/IRF7/MAP3K7/IFNGR1/IKBKG/HLA-DRB5/HLA-DQA1/NECTIN2/HLA-DMB/HLA-F/MYD88/TAPBPL	6.15003290790141
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	67/1293	250/9376	1.94336272235112	HSPA1A/HLA-A/HLA-B/HSPA1B/HLA-E/HLA-C/RAB11B/ACTR3/CAPZA1/SH3GL1/SNX6/VPS37A/USP8/AP2M1/RAB8A/HLA-G/SNX2/CYTH2/TGFBR2/ARPC5/EGFR/ARAP2/CHMP1A/AP2B1/ACTR2/SNX1/PSD4/ACAP3/SPART/RAB5C/VPS36/VPS26B/IGF1R/EPS15/CLTC/HGS/FOLR2/IST1/VPS37C/SMURF2/RNF41/ARFGAP2/SNX4/RBSN/DAB2/WASHC1/EPN1/CXCR4/RAB35/ARFGEF1/HSPA6/LDLR/STAM2/EHD1/DNM2/EHD4/GRK6/SNX5/RUFY2/TGFBR1/ARRB2/VPS45/PLD1/WASHC4/VPS37B/PLD2/HLA-F	6.04654228223477
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	53/1293	181/9376	2.12332448842685	HLA-DRA/CD74/TNFRSF1A/CD14/CYCS/LAMP2/ATP6V0C/ATP6V0B/HSPA9/CAMK2D/CALM3/ATP6V0D1/RIPK2/HLA-DRB1/MAPK3/HLA-DPB1/NFYB/CTSS/NFYC/FCER1G/RAB5C/ATP6V1H/HSPD1/CEBPG/FCGR3A/HLA-DPA1/FCGR2A/MRC1/CREB1/IL1B/MAPK1/BAX/ITGB2/IRAK1/AKT2/IFNGR2/MALT1/LSP1/JAK1/TNF/HLA-DMA/PIK3C3/CASP9/PLK3/IL10RA/CEBPB/IFNGR1/HLA-DRB5/HLA-DQA1/HLA-DMB/TCIRG1/CR1/MYD88	6.10333570688883
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	38/1293	112/9376	2.46028063197437	HSPA1A/NFKBIA/HLA-DRA/HSPA1B/GNAI3/TNFRSF1A/LAMA3/CYCS/LAMC1/GNAI2/HLA-DRB1/MAPK3/HLA-DPB1/TAB2/HLA-DPA1/LAMB2/PPIF/BIRC2/MAPK1/IRAK1/AKT2/IFNGR2/LAMA5/JAK1/TNF/HLA-DMA/HSPA6/LDLR/CASP9/ALOX5/MAP3K7/IL10RA/IFNGR1/IKBKG/HLA-DRB5/HLA-DQA1/HLA-DMB/MYD88	6.21791347696749
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	47/1293	155/9376	2.19879749519747	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/CD14/DYNC1LI1/LAMP2/CTSL/ATP6V0C/ATP6V0B/HLA-G/ITGA5/M6PR/ATP6V0D1/HLA-DRB1/OLR1/HLA-DPB1/CTSS/DYNC1H1/CANX/RAB5C/ATP6V1H/FCGR3A/HLA-DPA1/FCGR2A/TUBA1C/MRC1/HGS/ITGB2/TUBB/CD36/CYBB/ATP6V1C1/MSR1/NCF1/ATP6V1A/HLA-DMA/PIK3C3/TUBB2A/SCARB1/HLA-DRB5/HLA-DQA1/COLEC12/HLA-DMB/TCIRG1/HLA-F	6.01895749154072
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	29/1293	78/9376	2.6960160231622	FOS/NFKBIA/HLA-DRA/JUN/HLA-DRB1/MAPK3/HLA-DPB1/TAB2/FCGR3A/HLA-DPA1/FCGR2A/IL1B/MAPK1/ITGB2/IRAK1/CYBB/IFNGR2/NCF1/JAK1/TNF/HLA-DMA/MAP3K7/PTGS2/IFNGR1/HLA-DRB5/HLA-DQA1/HLA-DMB/CR1/MYD88	6.01562966917372
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	31/1293	87/9376	2.58381559413642	FOS/JUN/RPS6KB2/GADD45G/CYCS/EREG/TGFBR2/EGFR/MAPK3/APC/DDB2/PIK3R1/NRAS/ARAF/MSH3/MAPK1/BAX/MLH1/RPS6KB1/RAC3/AKT2/SOS2/GSK3B/MSH2/POLK/CASP9/SOS1/PIK3CA/CTNNB1/MAP2K1/TGFBR1	5.93578785399286
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	43/1293	142/9376	2.19583238020544	HUWE1/UBE2R2/UBA2/UBC/MID1/UBE2F/UBE2A/UBA1/UBE2D3/SAE1/BIRC6/CUL2/DDB2/UBE3A/FANCL/TRIP12/UBE4A/HERC4/BIRC2/UBA6/UBE4B/UBE2W/COP1/SMURF2/UBE2G2/CDC23/SOCS3/CUL1/ANAPC4/SKP1/UBE2H/ANAPC7/SYVN1/UBE3B/RCHY1/UBE2Z/BRCA1/VHL/CUL4B/ERCC8/PRPF19/TRIM37/KLHL9	5.74272681600706
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	64/1293	248/9376	1.87131701718933	FOS/CXCL8/NFKBIA/JUN/HSP90AA1/FLNA/RHOG/ARL8B/TNFRSF1A/ACTR3/CD14/KLC1/DYNC1LI1/CYCS/DYNLL2/ACTR1A/GCC2/DCTN1/CYTH2/ARL8A/ARPC5/M6PR/RIPK2/MAPK3/CASP4/TNFSF10/ACTR2/ABI1/DYNC1H1/RAB5C/TAB2/TUBA1C/IL1B/BIRC2/VPS16/DYNLRB1/MAPK1/BAX/TAB3/TUBB/IRAK1/AKT2/CYFIP1/EXOC4/KPNA1/SKP1/PLEKHM2/FYCO1/TNF/PIK3C3/TUBB2A/PIK3CA/SNX9/DCTN5/MAP3K7/PIK3C2A/CTNNB1/DNM2/MAP2K7/IKBKG/NAIP/MAP2K1/PTPRC/MYD88	5.56176752608574
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/1293	56/9376	2.97823444923213	HSPA1A/CXCL8/NFKBIA/HSPA1B/SAR1A/CD14/VCP/CYCS/RAB1A/EEF1G/CXCL2/HSPD1/BCL2L13/IL1B/CXCL3/ITGB2/TNF/HSPA6/CASP9/NAIP/CXCL1/CR1/MYD88	5.93830403177903
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	57/1293	216/9376	1.91355160264673	HSPA1A/FOS/CCL3/CXCL8/NFKBIA/HSPA1B/JUN/SOD2/HSP90AA1/TNFRSF1A/CD14/CYCS/PTK2/HSPA4/CAMK2D/CCL3L1/ATF6/CALM3/CXCL2/MAPK3/TNFSF10/OLR1/CCL2/PIK3R1/NRAS/HSPD1/TAB2/RXRA/RAP1B/IL1B/CXCL3/ICAM1/MAPK1/BAX/IRAK1/CD36/CYBB/AKT2/IRF3/CCL5/NCF1/ABCA1/NFE2L2/TNF/HSPA6/GSK3B/LDLR/CASP9/XBP1/TANK/PIK3CA/IRF7/MAP3K7/MAP2K7/IKBKG/CXCL1/MYD88	5.43263883462661
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	64/1293	253/9376	1.83433446744251	CXCL8/NFKBIA/JUN/RPS6KB2/SEPTIN2/TNFRSF1A/UBE2V1/ACTR3/CD14/CYCS/ILK/VCL/BECN1/PTK2/ROCK1/ATG12/UBC/SEPTIN9/ITGA5/CYTH2/CBX3/WIPI2/MAP1LC3B/ARPC5/EGFR/GSK3A/RIPK2/UBE2D3/PLCG2/MAPK3/CASP4/ACTR2/WIPI1/PIK3R1/HK1/TAB2/IL1B/MAPK1/BAX/TAB3/RPS6KB1/AKT2/IRF3/MALT1/CUL1/ACTN1/SKP1/CCL5/TIFA/SQSTM1/RPS6KA5/PLCD3/TLN2/TNF/GSK3B/DOCK1/PIK3C3/PIK3CA/MAP3K7/IKBKG/NAIP/ACTN4/CD44/MYD88	5.3805939580786
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	59/1293	227/9376	1.88471300905247	B2M/CCL4/HLA-A/HLA-B/CCL3/CXCL8/NFKBIA/CCL4L2/GNAI3/HLA-E/RPS6KB2/HLA-C/TNFRSF1A/GNG5/CYCS/PTK2/ROCK1/EIF4EBP1/HLA-G/AKAP13/RHEB/GNAI2/CCL3L1/EGFR/CALM3/MAPK3/GNG12/CCL2/PIK3R1/TAPBP/NRAS/CREB1/IL1B/MAPK1/BAX/RPS6KB1/RAC3/AKT2/IRF3/SOS2/PDIA3/CCL5/CXCR4/JAK1/TNF/GSK3B/CASP9/SOS1/PIK3CA/CTNNB1/IL10RA/PTGS2/IKBKG/CREB3L2/MAP2K1/ADCY7/ATF2/HLA-F/TAPBPL	5.39668586909746
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	23/1293	59/9376	2.82679879927117	GADD45G/CDH1/ILK/EGFR/MAPK3/APC/DDB2/PIK3R1/NRAS/ERBB2/ARAF/MAPK1/BAX/MLH1/AKT2/SOS2/GSK3B/POLK/CASP9/SOS1/PIK3CA/CTNNB1/MAP2K1	5.62959674349648
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	31/1293	95/9376	2.36623112305125	FOS/FLT1/CCL3/CXCL8/HLA-DRA/JUN/CTSL/ATP6V0C/ATP6V0B/CCL3L1/CXCL2/ATP6V0D1/HLA-DRB1/HLA-DPB1/CCL2/ATP6V1H/HLA-DPA1/IL1B/CXCL3/ICAM1/ITGB2/ATP6V1C1/CCL5/ATP6V1A/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/CXCL1/HLA-DMB/TCIRG1	5.35287623380189
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1293	105/9376	2.27899679593415	JUN/GABARAPL1/HUWE1/PHB2/VCP/BECN1/USP8/UBC/MAP1LC3B/CCZ1/RAB5C/NRAS/TBC1D15/NBR1/HIF1A/BCL2L13/MFN1/RHOT1/TOMM40/ULK1/SMURF2/OPA1/USP15/CITED2/CSNK2A2/RABGEF1/SQSTM1/TOMM70/TFE3/NLRX1/MFN2/ARIH1/MTX3	5.27107780475367
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	52/1293	205/9376	1.83936770226171	B2M/HLA-A/HLA-B/NFKBIA/HLA-DRA/JUN/ADRM1/HLA-E/HLA-C/GADD45G/CYCS/HLA-G/RBPJ/PLCG2/HLA-DRB1/HLA-DPB1/SAP30L/DDB2/SAP30/PIK3R1/TAPBP/CD58/TAB2/HLA-DPA1/ICAM1/BAX/IRAK1/USP7/AKT2/IRF3/EIF2AK2/PDIA3/ISG15/JAK1/TNF/HLA-DMA/POLK/CASP9/PIK3CA/CDK2/IRF7/MAP3K7/MAP2K7/IKBKG/TNFAIP3/HLA-DRB5/HLA-DQA1/CD44/HLA-DMB/HLA-F/MYD88/TAPBPL	4.85981177740301
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	18/1293	44/9376	2.96646277156718	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/HLA-G/HLA-DRB1/ICA1/HLA-DPB1/HSPD1/HLA-DPA1/IL1B/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB/HLA-F	5.22905624612135
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	45/1293	173/9376	1.88619020157451	CXCL8/NFKBIA/HLA-DRA/RAB11B/TNFRSF1A/DNAJC3/CYCS/SLC25A6/XPO1/HLA-DRB1/MAPK3/SLC25A5/TNFSF10/HLA-DPB1/CCL2/KPNA6/PIK3R1/IFIH1/HLA-DPA1/IL1B/ICAM1/MAPK1/BAX/AKT2/IFNGR2/SOCS3/IRF3/KPNA1/EIF2AK2/CCL5/JAK1/TNF/HLA-DMA/CASP9/PIK3CA/NLRX1/IRF7/IFNGR1/IKBKG/DNAJB1/MAP2K1/HLA-DRB5/HLA-DQA1/HLA-DMB/MYD88	4.70526291699351
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	31/1293	103/9376	2.18244618145503	FOS/CCL3/CXCL8/NFKBIA/SERPINE1/JUN/C1QA/GNAI3/TNFRSF1A/C1QB/GNAI2/CCL3L1/TGFBR2/MAPK3/PPP2R2D/CCL2/C1QC/PIK3R1/IL1B/MAPK1/IRAK1/AKT2/IFNGR2/CFLAR/CCL5/TNF/PIK3CA/IFNGR1/IKBKG/TGFBR1/MYD88	4.82601288199531
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	26/1293	80/9376	2.35668986852282	RPS6KB2/EIF4EBP1/EGFR/PLCG2/MAPK3/EIF4E/PIK3R1/NRAS/ERBB2/ERBB3/ARAF/IGF1R/MAPK1/BAX/SHC1/RPS6KB1/PDGFB/AKT2/HGF/SOS2/JAK1/GAB1/GSK3B/SOS1/PIK3CA/MAP2K1	4.87389455347549
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	49/1293	196/9376	1.81283836040217	FOS/HLA-A/HLA-B/CXCL8/NFKBIA/JUN/HLA-E/HLA-C/ATG3/TNFRSF1A/GNG5/CYCS/BECN1/UBC/HLA-G/MAP1LC3B/CALM3/CXCL2/PLCG2/MAPK3/ZFP36/GNG12/PIK3R1/NRAS/HIF1A/CREB1/CXCL3/ICAM1/MAPK1/BAX/PDGFB/AKT2/IRF3/EIF2AK2/JAK1/IL6ST/GSK3B/PIK3C3/CASP9/PIK3CA/IRF7/CTNNB1/MAP2K7/PTGS2/IFNGR1/IKBKG/MAP2K1/CXCL1/HLA-F	4.59948807772657
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	31/1293	105/9376	2.14087577799875	CCL4/CXCL8/NFKBIA/CCL4L2/GADD45G/TNFRSF1A/CD14/CYLD/BCL2A1/CXCL2/LTBR/PLCG2/PARP1/TAB2/IL1B/BIRC2/CXCL3/ICAM1/TAB3/IRAK1/CFLAR/MALT1/CSNK2A2/TNF/ERC1/MAP3K7/PTGS2/IKBKG/TNFAIP3/CXCL1/MYD88	4.70184523566225
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	27/1293	86/9376	2.27658770841202	JUN/RPS6KB2/PTK2/EIF4EBP1/EREG/CAMK2D/EGFR/PLCG2/MAPK3/PIK3R1/NRAS/ERBB2/ERBB3/ARAF/NCK2/MAPK1/SHC1/RPS6KB1/AKT2/SOS2/GAB1/GSK3B/SOS1/PIK3CA/MAP2K7/NCK1/MAP2K1	4.75653436066024
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	38/1293	142/9376	1.94050303366992	FOS/FOSB/NFKBIA/JUN/JUNB/TYROBP/TNFRSF1A/CYLD/TGFBR2/JUND/PLCG2/MAPK3/CSF1R/PIK3R1/TAB2/FCGR3A/FCGR2A/GAB2/CREB1/IL1B/MAPK1/AKT2/IFNGR2/SOCS3/SPI1/NCF1/SQSTM1/JAK1/TNF/PIK3CA/MAP3K7/LILRB5/MAP2K7/IFNGR1/IKBKG/MAP2K1/SIRPA/TGFBR1	4.51656275695125
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	28/1293	93/9376	2.18320318672089	FN1/NFKBIA/COL4A1/GADD45G/LAMA3/CYCS/MAX/LAMC1/PTK2/COL4A2/CKS1B/DDB2/PIK3R1/TRAF4/RXRA/LAMB2/BIRC2/BAX/AKT2/LAMA5/FHIT/POLK/CASP9/PIK3CA/CDK2/PTGS2/IKBKG/ZBTB17	4.5862237706026
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	23/1293	70/9376	2.3825875593857	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/EIF4G1/CYCS/HLA-G/HLA-DRB1/HLA-DPB1/HLA-DPA1/DAG1/ICAM1/ITGB2/RAC3/EIF4G2/HLA-DMA/CASP9/HLA-DRB5/HLA-DQA1/HLA-DMB/EIF4G3/HLA-F	4.64364222807962
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	51/1293	214/9376	1.72812628748618	B2M/FOS/HLA-A/HLA-B/NFKBIA/JUN/GNAI3/HLA-E/RPS6KB2/HLA-C/TNFRSF1A/GNG5/CYCS/PTK2/HLA-G/GNAI2/CALM3/PLCG2/MAPK3/GNG12/PIK3R1/TAPBP/NRAS/AP1G2/TAB2/MAPK1/BAX/IRAK1/RPS6KB1/RAC3/AKT2/IRF3/CUL1/AP1M1/PDIA3/SKP1/CXCR4/AP1G1/TNF/CASP9/PIK3CA/MAP3K7/TNFRSF1B/CD4/MAP2K7/CUL4B/IKBKG/MAP2K1/HLA-F/MYD88/TAPBPL	4.30940255517167
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	66/1293	300/9376	1.59529775715391	HSPA1A/FOS/FLT1/HSPA1B/JUN/FLNA/CDC25B/GADD45G/NR4A1/TNFRSF1A/CD14/DUSP1/MAX/EREG/LAMTOR3/TGFBR2/EGFR/JUND/DUSP3/MAPK3/MAP4K4/GNG12/TAOK3/RPS6KA4/CSF1R/DUSP2/DUSP7/NRAS/ERBB2/ERBB3/TAB2/ARAF/RAP1B/IL1B/IGF1R/MAPK1/IRAK1/TAOK1/PPP5C/RAC3/PDGFB/AKT2/HGF/SOS2/DUSP6/RASA2/FGFR1/STK4/MAP3K6/RPS6KA5/TNF/DUSP5/HSPA6/ELK4/SOS1/MAP3K7/MAP2K7/IKBKG/MAP2K1/TGFBR1/ARRB2/MAP4K3/ATF2/PTPRR/NTF4/MYD88	4.19127581440212
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	16/1293	42/9376	2.76242035870806	FTL/SAT1/VDAC3/PCBP2/SLC39A8/MAP1LC3B/GSS/HMOX1/FTH1/NCOA4/PRNP/CYBB/ACSL1/GCLM/SLC39A14/SLC3A2	4.57824320094176
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	23/1293	73/9376	2.28467300215067	GADD45G/EGFR/PLCG2/MAPK3/DDB2/PIK3R1/NRAS/ERBB2/ARAF/RXRA/MAPK1/BAX/AKT2/HGF/SOS2/STK4/FHIT/RASSF1/POLK/CASP9/SOS1/PIK3CA/MAP2K1	4.40698049332722
NA	NA	hsa04518	Integrin signaling	39/1293	154/9376	1.83638171573206	SPP1/FN1/FLT1/COL4A1/FLNA/CDH1/LAMA3/ILK/VCL/LAMC1/PTK2/COL4A2/ITGA5/EGFR/FERMT2/FBN1/PIK3R1/ERBB2/LAMB2/NCK2/IGF1R/ICAM1/COL1A1/ITGB2/RAC3/PDGFB/AKT2/HGF/ACTN1/LAMA5/TLN2/ICAM3/GSK3B/LIMS1/PIK3CA/CTNNB1/ACTN4/COL6A1/FERMT3	4.18553466153714
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	29/1293	103/9376	2.04164320200632	PPP2R5C/RNPS1/WDR33/UPF2/FIP1L1/DAZAP1/PABPC4/PPP2R5E/TARDBP/CPSF6/PPP2R2D/GSPT1/RBM8A/CPSF3/UPF3B/ETF1/NCBP2/CASC3/CSTF2T/PPP2R3C/DDX39B/CSTF2/PPP2R5D/FUS/RNGTT/PNN/SMG5/CPSF2/CPSF7	4.25134233605415
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	45/1293	187/9376	1.74497810092187	CXCL8/NFKBIA/JUN/VDAC3/GABARAPL1/HSP90AA1/ATG12/DNM1L/MAP1LC3B/CXCL2/RIPK2/MAPK3/CASP4/CTSB/CCL2/TAB2/PKN2/YWHAE/IL1B/GBP3/BIRC2/CXCL3/MFN1/MAPK1/TAB3/CYBB/IRF3/ANTXR2/ERBIN/CCL5/JAK1/TNF/GPSM3/TANK/MCU/NLRX1/MFN2/IRF7/MAP3K7/TRPM7/IKBKG/TNFAIP3/NAIP/CXCL1/MYD88	4.11555865211327
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/1293	39/9376	2.78898209292641	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/HLA-G/HLA-DRB1/HLA-DPB1/HLA-DPA1/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB/HLA-F	4.4774756099655
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	26/1293	90/9376	2.09483543868695	SOD2/RPS6KB2/RB1CC1/EIF4EBP1/RHEB/EIF4E/PIK3R1/NRAS/CREB1/IGF1R/PRKAA1/STK11/BAX/ULK1/PRKAG2/RPS6KB1/AKT2/CAMKK2/SESN3/ATG13/IRS2/PIK3CA/CREB3L2/EHMT1/ADCY7/ATF2	4.17401853188735
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	30/1293	110/9376	1.97764184771145	FLT1/SERPINE1/RPS6KB2/PFKL/EIF4EBP1/CAMK2D/EGFR/LTBR/PLCG2/MAPK3/CUL2/EIF4E/PIK3R1/HMOX1/HK1/ERBB2/LDHA/HIF1A/EPAS1/IGF1R/MAPK1/CYBB/RPS6KB1/TIMP1/AKT2/IFNGR2/PIK3CA/VHL/IFNGR1/MAP2K1	4.12504403525938
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/1293	44/9376	2.6368557969486	MAN1A2/TUSC3/MAN1B1/RPN2/HEXB/DDOST/ALG13/B4GALT3/MGAT2/ALG2/STT3A/STT3B/MAN1A1/MGAT1/HEXA/ALG12	4.35259245829136
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	70/1293	333/9376	1.52430853126909	SPP1/FN1/HLA-A/HLA-B/COL4A1/PPP2R5C/HLA-E/RPS6KB2/HLA-C/TNFRSF1A/LAMA3/LAMC1/PTK2/ATP6V0C/TADA3/EIF4EBP1/PPP2R5E/ATP6V0B/COL4A2/HLA-G/ITGA5/RHEB/EGFR/RBPJ/ATP6V0D1/MAPK3/PPP2R2D/APC/RBL2/PIK3R1/ATP6V1H/NRAS/DLG1/UBE3A/LAMB2/CREB1/FZD1/COL1A1/MAPK1/NFX1/BAX/ATP6V1C1/DVL3/RPS6KB1/AKT2/PPP2R3C/IRF3/SOS2/EIF2AK2/ISG15/TBP/LAMA5/ATP6V1A/IRF1/PPP2R5D/MAML2/JAK1/TNF/GSK3B/SOS1/PIK3CA/CDK2/CTNNB1/PTGS2/IKBKG/CREB3L2/MAP2K1/TCIRG1/COL6A1/HLA-F	3.89629101469484
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1293	101/9376	2.01027620163408	FN1/CXCL8/SERPINE1/JUN/COL4A1/EGR1/COL4A2/TGFBR2/PLCG2/MAPK3/CCL2/PIK3R1/NRAS/THBD/IL1B/ICAM1/COL1A1/MAPK1/BAX/CYBB/AKT2/PIM1/PLCD3/TNF/COL3A1/PIK3CA/MMP2/TGFBR1	4.08265293001145
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	23/1293	77/9376	2.16598869035064	RPS6KB2/GADD45G/TGFBR2/EGFR/MAPK3/DDB2/PIK3R1/ERBB2/ARAF/MAPK1/BAX/RPS6KB1/RAC3/AKT2/JAK1/POLK/CASP9/PIK3CA/IKBKG/MAP2K1/TGFBR1/PLD1/PLD2	4.10884906308796
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	23/1293	77/9376	2.16598869035064	NFKBIA/GADD45G/TGFBR2/MAPK3/DDB2/PIK3R1/NRAS/ARAF/GAB2/CTBP2/MAPK1/BAX/SHC1/AKT2/SOS2/POLK/SOS1/PIK3CA/CTBP1/IKBKG/MAP2K1/TGFBR1/BCR	4.10884906308796
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	35/1293	138/9376	1.83911138011814	FN1/FOS/CXCL8/NFKBIA/JUN/RHOG/ACTR3/PTK2/ROCK1/ITGA5/ARPC5/MAPK3/ACTR2/CCL2/PIK3R1/TAB2/PKN2/FCGR2A/IL1B/MAPK1/IRAK1/RAC3/AKT2/IRF3/FYB1/TNF/GSK3B/DOCK1/PIK3CA/MAP3K7/CD4/MAP2K7/IKBKG/MAP2K1/MYD88	3.97163003707406
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1293	45/9376	2.57825900146086	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/HLA-G/HLA-DRB1/HLA-DPB1/HLA-DPA1/IL1B/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB/HLA-F	4.24442680297288
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	21/1293	68/9376	2.23938856284973	RPS6KB2/CD14/EIF4EBP1/BCL2A1/MAPK3/CSF1R/PIK3R1/NRAS/ARAF/MAPK1/PPARD/RPS6KB1/AKT2/SOS2/SPI1/DUSP6/PIM1/SOS1/PIK3CA/IKBKG/MAP2K1	4.10234673290114
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1293	41/9376	2.65293418595439	CXCL8/DAPK1/CDH1/EGFR/MAPK3/NRAS/ERBB2/TYMP/ARAF/MAPK1/DAPK3/RASSF1/RPS6KA5/MMP2/MAP2K1	4.24217851685874
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1293	78/9376	2.13821960457691	XRN1/PFKL/EXOSC8/EXOSC1/DHX36/PABPC4/HSPA9/CNOT4/MTREX/HSPD1/CNOT8/BTG2/DDX6/CNOT9/PAN3/EXOSC6/DIS3/BTG3/CNOT1/PNPT1/CNOT6L/CNOT10/CNOT6	4.03717154190663
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	24/1293	83/9376	2.09677689877841	MAX/TFDP1/CBX3/UBE2D3/SUZ12/BMI1/RBBP7/AEBP2/PHF19/USP7/RBBP4/PCGF5/PCGF1/FOXK2/KDM2A/PHC2/SKP1/FBRSL1/PCGF3/BAP1/EED/MBD5/L3MBTL2/RYBP	4.01400568521295
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	26/1293	93/9376	2.02726010195511	AFDN/CDH1/VCL/ROCK1/TGFBR2/EGFR/MAPK3/HEG1/PTPN1/ERBB2/IQGAP1/RAP1B/IGF1R/MAPK1/SMURF2/RAC3/ACTN1/FGFR1/KRIT1/CSNK2A2/PTPRM/MAP3K7/CTNNB1/ACTN4/TGFBR1/NECTIN2	3.98177147513848
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	26/1293	94/9376	2.0056935051258	FOS/FOSB/CXCL8/NFKBIA/JUN/HSP90AA1/ELAVL1/JUND/CXCL2/MAPK3/CCL2/TRAF4/TAB2/IL1B/CXCL3/MAPK1/TAB3/S100A9/TNF/GSK3B/MAP3K7/CEBPB/PTGS2/IKBKG/TNFAIP3/CXCL1	3.91929001806094
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	33/1293	133/9376	1.79920799679012	SOD2/GABARAPL1/GADD45G/ATG12/PRMT1/TGFBR2/EGFR/MAPK3/TNFSF10/RBL2/PIK3R1/NRAS/CDKN2D/ARAF/CCNG2/IGF1R/PRKAA1/STK11/MAPK1/USP7/PRKAG2/AKT2/SOS2/HOMER3/STK4/SGK1/IRS2/SOS1/PIK3CA/CDK2/PLK3/MAP2K1/TGFBR1	3.71259671405198
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	46/1293	205/9376	1.62713296738536	HLA-A/HLA-B/NFKBIA/JUN/VDAC3/HLA-E/HLA-C/HLA-G/YWHAG/RBPJ/LTBR/ATP6V0D1/MAPK3/HNRNPK/RBL2/PIK3R1/NRAS/DLG1/UBE3A/HDAC3/YWHAE/VAC14/CREB1/MAPK1/BAX/USP7/POLB/IRF3/ACTN1/EIF2AK2/RASA2/TBP/GTF2A1/JAK1/IL6ST/PIK3CA/CDK2/IRF7/IKBKG/CREB3L2/ACTN4/HDAC8/GTF2B/ATF2/SCIN/HLA-F	3.63100482980794
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	35/1293	144/9376	1.76248173927988	CXCL8/NFKBIA/C1QA/TNFRSF1A/CD14/ACADVL/C1QB/CXCL2/C5AR1/C1QC/ADH5/TAB2/ACADM/CPT1A/IL1B/PRKAA1/CXCL3/TAB3/IRAK1/PRKAG2/AKT2/IRF3/CAMKK2/ALDH7A1/TNF/GSK3B/LPIN3/C3AR1/MAP3K7/CTNNB1/MAP2K7/IKBKG/CXCL1/C2/MYD88	3.68774944721226
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	38/1293	163/9376	1.69049957534435	FOS/CXCL8/NFKBIA/JUN/VDAC3/PCNA/CYCS/TGFBR2/MAPK3/DDB2/PIK3R1/NRAS/TAB2/IFIH1/ARAF/CREB1/MAPK1/BAX/IRAK1/AKT2/IRF3/SOS2/HSPG2/JAK1/TNF/CASP9/SOS1/PIK3CA/CDK2/IRF7/MAP3K7/MAP2K7/IKBKG/CREB3L2/MAP2K1/TGFBR1/ATF2/MYD88	3.55676599868086
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	28/1293	109/9376	1.8627329941747	SPP1/CCL4/FOS/CCL3/CXCL8/NFKBIA/JUN/CCL4L2/CD14/CCL3L1/MAPK3/PIK3R1/TAB2/IL1B/MAPK1/IRAK1/AKT2/IRF3/CCL5/JAK1/TNF/PIK3CA/IRF7/MAP3K7/MAP2K7/IKBKG/MAP2K1/MYD88	3.62342007483647
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	45/1293	203/9376	1.60744288114478	SPP1/FN1/FLT1/JUN/COL4A1/FLNA/LAMA3/ILK/VCL/LAMC1/PTK2/ROCK1/COL4A2/ITGA5/EGFR/MAPK3/PIK3R1/ERBB2/LAMB2/RAP1B/IGF1R/BIRC2/PPP1R12A/COL1A1/MAPK1/VASP/SHC1/RAC3/PDGFB/AKT2/HGF/ARHGAP35/SOS2/ACTN1/LAMA5/TLN2/GSK3B/DOCK1/SOS1/PIK3CA/CTNNB1/ZYX/MAP2K1/ACTN4/COL6A1	3.49942250289823
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	39/1293	170/9376	1.66354578954552	RPS6KB2/GADD45G/PHF10/SMARCA2/TGFBR2/EGFR/PLCG2/MAPK3/SMARCC1/APC/DDB2/PIK3R1/SMARCE1/HMOX1/NRAS/SMARCA4/ARAF/PBRM1/IGF1R/FZD1/MAPK1/BAX/SMARCD1/SHC1/DVL3/RPS6KB1/AKT2/HGF/SOS2/NFE2L2/GAB1/GSK3B/POLK/SOS1/PIK3CA/CTNNB1/TXNRD1/MAP2K1/TGFBR1	3.49187335734677
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1293	37/9376	2.54777283083548	GADD45G/CDH1/MAPK3/DDB2/NRAS/RXRA/NCOA4/MAPK1/BAX/POLK/CTNNB1/PAX8/MAP2K1	3.77273676703258
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1293	70/9376	2.07181526903105	JUN/MAPK3/CUL2/PIK3R1/NRAS/ARAF/HIF1A/EPAS1/RAP1B/MAPK1/PDGFB/AKT2/HGF/SOS2/GAB1/TFE3/SOS1/PIK3CA/VHL/MAP2K1	3.59986361094155
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	36/1293	156/9376	1.67338925575584	NFKBIA/TNFRSF1A/CYCS/EGFR/YWHAG/MAPK3/PPP2R2D/PIK3R1/NRAS/ARAF/RXRA/YWHAE/MAPK1/BAX/AKT2/SOCS3/CFLAR/IRF3/SOS2/EIF2AK2/JAK1/TNF/CLDN15/GSK3B/LDLR/CASP9/SOS1/PIK3CA/CDK2/IRF7/CTNNB1/SCARB1/IKBKG/MAP2K1/CLDN12/CLDN19	3.39204521483754
Human Diseases	Cancer: specific types	hsa05214	Glioma	21/1293	76/9376	2.00366345097081	GADD45G/CAMK2D/EGFR/CALM3/PLCG2/MAPK3/DDB2/PIK3R1/NRAS/ARAF/IGF1R/MAPK1/BAX/SHC1/PDGFB/AKT2/SOS2/POLK/SOS1/PIK3CA/MAP2K1	3.51359776709419
Genetic Information Processing	Transcription	hsa03040	Spliceosome	51/1293	243/9376	1.52188899391787	HSPA1A/HSPA1B/BCAS2/U2SURP/SNRPD3/CDC5L/HNRNPM/CCDC12/PRPF40A/RBM17/XAB2/DDX42/THOC2/HNRNPC/SNRNP40/HNRNPK/DHX15/USP39/PRPF18/CRNKL1/SF3B1/RBM8A/RBM22/DDX23/TCERG1/PRPF38A/RBMX/RBM25/SNRNP70/ISY1/SNRNP27/NCBP2/CASC3/GPKOW/PRPF4/SF3A1/SF1/DDX5/SRSF7/YJU2/DDX39B/SMNDC1/SF3B3/SNRNP200/PRPF38B/HSPA6/FUS/AQR/EFTUD2/PRPF19/THOC1	3.29665239955705
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	36/1293	157/9376	1.66273072546441	HLA-A/HLA-B/CXCL8/SERPINE1/VDAC3/HLA-E/HLA-C/GADD45G/EIF4EBP1/HIPK3/HLA-G/RHEB/TGFBR2/SLC25A6/CALM3/MAPK3/SLC25A5/RBL2/PIK3R1/MRE11/NRAS/MAPK1/ZFP36L2/HIPK2/RBBP4/AKT2/SQSTM1/RAD9A/PIK3CA/MCU/CDK2/TRPM7/ZFP36L1/MAP2K1/TGFBR1/HLA-F	3.34921968988771
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	31/1293	130/9376	1.72916889761437	FOS/NFKBIA/JUN/GNAI3/COL4A1/GNG5/COL4A2/GNAI2/TGFBR2/EGFR/MAPK3/GNG12/PIK3R1/NRAS/CREB1/COL1A1/MAPK1/SHC1/AKT2/SOS2/COL3A1/SOS1/PIK3CA/MAP2K7/MMP2/CREB3L2/MAP2K1/TGFBR1/ARRB2/ADCY7/ATF2	3.3482777630313
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/1293	125/9376	1.74032482598608	GNAI3/PPP2R5C/SPTLC1/TNFRSF1A/ROCK1/PPP2R5E/GNAI2/MAPK3/PPP2R2D/ORMDL1/ORMDL3/FCER1G/PIK3R1/CERS5/NRAS/GAB2/MAPK1/BAX/RAC3/AKT2/PPP2R3C/S1PR3/SGMS1/NSMAF/PPP2R5D/TNF/PIK3CA/MAP2K1/PLD1/PLD2	3.33258772612545
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	44/1293	204/9376	1.56401740897442	FN1/TIMP3/FLNA/RPS6KB2/EIF4B/PTK2/ROCK1/CTSL/ITGA5/CAMK2D/EGFR/PLCG2/MAPK3/PIK3R1/PLAUR/NRAS/ERBB2/ERBB3/ARAF/IQGAP1/HIF1A/IGF1R/PPP1R12A/FZD1/COL1A1/MAPK1/RPS6KB1/DDX5/AKT2/HGF/SOS2/HSPG2/FGFR1/TIAM1/GAB1/TNF/SOS1/PIK3CA/CTNNB1/DCN/MMP2/MAP2K1/CD44/DROSHA	3.257423169088
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/1293	48/9376	2.26604795050271	ACAT1/AACS/ACADM/HADH/OXCT1/HMGCS1/HIBADH/ACADSB/IVD/ALDH7A1/DBT/MCCC2/ACSF3/ABAT/ALDH6A1	3.51702224933179
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	27/1293	109/9376	1.79620681581132	FOS/NFKBIA/HLA-DRA/JUN/HSP90AA1/TGFBR2/EBI3/HLA-DRB1/MAPK3/HLA-DPB1/HIF1A/RXRA/HLA-DPA1/IL1B/GATA3/MAPK1/IFNGR2/JAK1/HLA-DMA/IL6ST/CD4/IFNGR1/IKBKG/HLA-DRB5/HLA-DQA1/TGFBR1/HLA-DMB	3.3440146367558
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/1293	78/9376	1.95228746504849	FOS/CXCL8/JUN/C1QA/GNAI3/CD14/C1QB/ITGA5/GNAI2/CALM3/MAPK3/C1QC/IL1B/MAPK1/ITGB2/IRAK1/IRF3/IRF1/TNF/C2/MYD88	3.37768549948426
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	32/1293	137/9376	1.69374678928086	FOS/NFKBIA/JUN/GADD45G/TNFRSF1A/SPTAN1/CYCS/CTSL/BCL2A1/MAPK3/TNFSF10/CTSB/CTSS/PARP1/PARP4/MCL1/PIK3R1/NRAS/TUBA1C/BIRC2/MAPK1/BAX/AKT2/CFLAR/PARP2/ENDOG/TNF/CASP9/PIK3CA/CTSC/IKBKG/MAP2K1	3.27150356166276
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1293	44/9376	2.30724882233003	TAF10/TAF7/TAF13/GTF2I/CCNH/GTF2F1/TAF6/ERCC3/TAF8/TBP/TAF2/GTF2A1/TAF3/GTF2B	3.47612867046137
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	43/1293	200/9376	1.55904098994586	FOS/CXCL8/NFKBIA/JUN/TNFRSF1A/ACTR3/CYCS/RAB1A/ROCK1/CYTH2/NCL/ARPC5/MAPK3/CASP4/TNFSF10/ACTR2/ABI1/TAB2/FCGR2A/TUBA1C/NCK2/IL1B/BAIAP2L1/MAPK1/BAX/TAB3/TUBB/IRAK1/CYFIP1/SEC24B/TNF/CLDN15/CASP9/TUBB2A/MAP3K7/NCK1/IKBKG/NAIP/CLDN12/CLDN19/MYH10/MYH9/MYD88	3.19617506461364
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1293	362/9376	1.40219541688565	SPP1/FN1/FLT1/CSH1/COL4A1/PPP2R5C/HSP90AA1/RPS6KB2/CDC37/NR4A1/LAMA3/EIF4B/GNG5/LAMC1/PTK2/EIF4EBP1/EREG/PPP2R5E/COL4A2/ITGA5/RHEB/EGFR/YWHAG/MAPK3/PPP2R2D/GNG12/RBL2/EIF4E/CSF1R/MCL1/PIK3R1/NRAS/ERBB2/ERBB3/PKN2/RXRA/YWHAE/LAMB2/CREB1/IGF1R/PRKAA1/STK11/COL1A1/MAPK1/RPS6KB1/PDGFB/AKT2/HGF/PPP2R3C/SOS2/DDIT4/FGFR1/LAMA5/PPP2R5D/JAK1/CSF3R/GSK3B/CASP9/LPAR6/SGK1/SOS1/PIK3CA/CDK2/BRCA1/IKBKG/CREB3L2/MAP2K1/COL6A1/ATF2/NTF4	3.12126927313152
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	32/1293	138/9376	1.6814732618223	PYGL/RPS6KB2/PRKAR1A/EIF4EBP1/RHEB/CALM3/PHKB/MAPK3/PRKAR2A/PYGB/EIF4E/PIK3R1/HK1/PTPN1/NRAS/ARAF/PRKAA1/MAPK1/SHC1/PRKAG2/RPS6KB1/AKT2/SOCS3/SOS2/FLOT1/GSK3B/IRS2/SOS1/PIK3CA/SOCS2/PHKA1/MAP2K1	3.22550705454051
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	29/1293	122/9376	1.72368237546435	PPP2R5C/RPS6KB2/RAB11B/PFKL/EIF4EBP1/PPP2R5E/RAB8A/ELAVL1/RHEB/PPP2R2D/PIK3R1/CPT1A/CREB1/IGF1R/PRKAA1/STK11/EEF2/ULK1/CD36/PRKAG2/RPS6KB1/AKT2/PPP2R3C/CAMKK2/PPP2R5D/IRS2/PIK3CA/MAP3K7/CREB3L2	3.21782020964175
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	26/1293	106/9376	1.77863386303609	NFKBIA/HSP90AA1/EGFR/MAPK3/PIK3R1/NRAS/ERBB2/ARAF/CREB1/IGF1R/MAPK1/FOLR2/PDGFB/AKT2/SOS2/FGFR1/GSK3B/CASP9/SOS1/PIK3CA/CDK2/CTNNB1/IKBKG/IL1R2/CREB3L2/MAP2K1	3.22437068629811
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	35/1293	158/9376	1.60631247124243	CDKN1C/PPP2R5C/CDC25B/GADD45G/PRKDC/PCNA/PPP2R5E/TFDP1/RAD21/ATRX/TFDP2/YWHAG/PDS5A/SMC1A/RBL2/STAG2/CCNH/CDKN2D/YWHAE/STAG1/NIPBL/CDC23/CUL1/ANAPC4/ESCO1/SKP1/ANAPC7/PPP2R5D/GSK3B/ORC2/CDK2/WAPL/CDC14B/HDAC8/ZBTB17	3.07401019956197
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1293	32/9376	2.49265274555298	GABARAPL1/ATG3/BECN1/ATG12/WIPI2/WIPI1/ATG4B/ATG13/ATG4D/ATG4A/PIK3C3	3.38271936517543
Human Diseases	Immune disease	hsa05310	Asthma	11/1293	32/9376	2.49265274555298	PRG2/HLA-DRA/HLA-DRB1/HLA-DPB1/FCER1G/HLA-DPA1/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB	3.38271936517543
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/1293	71/9376	1.94050303366992	CXCL8/NFKBIA/JUN/ADAM10/ATP6V0C/ATP6V0B/EGFR/CXCL2/ATP6V0D1/PLCG2/ATP6V1H/CXCL3/ATP6V1C1/CCL5/ATP6V1A/IKBKG/F11R/CXCL1/TCIRG1	3.18148439661496
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1293	71/9376	1.94050303366992	PFKL/SLC16A3/EGFR/MAPK3/PIK3R1/HK1/NRAS/ERBB2/LDHA/HIF1A/IDH2/MAPK1/SIRT6/AKT2/FGFR1/PIK3CA/MAP2K1/IDH1/SCO2	3.18148439661496
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/1293	103/9376	1.7600372431089	FN1/CXCL8/COL4A1/CD14/LAMA3/VCL/LAMC1/PTK2/COL4A2/CXCL2/PIK3R1/RAB5C/LAMB2/IL1B/CXCL3/COL1A1/ITGB2/ACTN1/LAMA5/TNF/COL3A1/PIK3CA/IL1R2/CXCL1/ACTN4	3.10200124417183
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1293	388/9376	1.36430103411709	MT-ATP6/APOE/MT-ND1/ADRM1/VDAC3/NDUFV1/MT-CO3/MT-ND2/TNFRSF1A/MT-ND4/KLC1/APH1A/CYCS/BECN1/SLC39A8/RB1CC1/ADAM10/MT-CO1/PSMB4/NDUFA13/SDHD/WIPI2/SLC25A6/ATF6/CALM3/SLC39A13/SLC39A3/MAPK3/SLC25A5/APC/WIPI1/PIK3R1/MT-CYB/NRAS/ARAF/TUBA1C/NCSTN/MT-ND3/PPIF/CDK5/IL1B/FZD1/MAPK1/TUBB/ULK1/CYBB/SDHA/DVL3/AKT2/APH1B/MT-ATP8/EIF2AK2/MT-ND4L/CSNK2A2/ATG13/SLC39A14/TNF/NDUFA6/GSK3B/PIK3C3/CASP9/TUBB2A/IRS2/XBP1/PIK3CA/MCU/CTNNB1/MAP2K7/PTGS2/IKBKG/MAP2K1/SLC39A7/IDE	2.93118578743563
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/1293	98/9376	1.77584165916947	RPS6KB2/ACTR3/ARPC5/PLCG2/MAPK3/ACTR2/PIK3R1/FCGR3A/FCGR2A/GAB2/PLPP1/MAPK1/VASP/RPS6KB1/AKT2/NCF1/DOCK1/PIK3CA/DNM2/MAP2K1/PLD1/PTPRC/PLD2/SCIN	3.08785970723714
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/1293	120/9376	1.69198246970869	NFKBIA/JUN/CAMK2D/CALM3/RIPK2/PLCG2/MAPK3/PIK3R1/NRAS/ARHGDIB/YWHAE/RAP1B/PRDM4/MAPK1/BAX/IRAK1/SHC1/AKT2/MAGED1/SOS2/RPS6KA5/GAB1/GSK3B/SOS1/PIK3CA/MAP2K7/MAP2K1/NTF4	3.05121389688162
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1293	33/9376	2.41711781386955	STX5/BET1/BET1L/GOSR2/SNAP29/STX4/VAMP7/STX2/STX3/STX11/BNIP1	3.26150736917761
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	24/1293	99/9376	1.7579038646324	FOS/JUN/RPS6KB2/CHPT1/EIF4EBP1/RHEB/EGFR/MAPK3/PIK3R1/NRAS/SLC22A5/HIF1A/PLPP1/MAPK1/RPS6KB1/RAC3/PDGFB/AKT2/SOS2/SOS1/PIK3CA/MAP2K1/PLD1/PLD2	3.03198153321767
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/1293	78/9376	1.85932139528427	FN1/RHOG/SEPTIN2/ACTR3/CDH1/ILK/VCL/PTK2/SEPTIN9/ITGA5/ARPC5/ACTR2/PIK3R1/CLTC/SHC1/GAB1/DOCK1/PIK3CA/CTNNB1/DNM2	3.04794247827308
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	27/1293	116/9376	1.68781502520202	GNAI3/AFDN/VCL/PTK2/ROCK1/GNAI2/PLCG2/PIK3R1/RAP1B/ICAM1/ITGB2/VASP/SIPA1/CYBB/ARHGAP35/ACTN1/PECAM1/NCF1/CXCR4/CLDN15/PIK3CA/CTNNB1/MMP2/CLDN12/F11R/ACTN4/CLDN19	2.98121825015794
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	12/1293	38/9376	2.28990108682379	UAP1/HEXB/GALK1/GMPPB/GMPPA/PGM3/HK1/GNPNAT1/NAGK/UGDH/GFPT1/HEXA	3.18654373442894
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	28/1293	122/9376	1.66424505217248	FOS/NFKBIA/JUN/PPP2R5C/PPP2R5E/MAPK3/PPP2R2D/PIK3R1/NRAS/DLG1/NCK2/MAPK1/AKT2/PPP2R3C/MALT1/SOS2/PPP2R5D/TNF/GSK3B/SOS1/PIK3CA/MAP3K7/CD4/MAP2K7/NCK1/IKBKG/MAP2K1/PTPRC	2.95353490081012
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/1293	227/9376	1.46943726129515	FOS/MT-ATP6/NFKBIA/MT-ND1/JUN/SOD2/VDAC3/NDUFV1/MT-CO3/MT-ND2/MT-ND4/PTK2/MT-CO1/NDUFA13/SDHD/SLC25A6/EGFR/MAPK3/SLC25A5/PIK3R1/MT-CYB/HMOX1/PTPN1/NRAS/ARAF/HIF1A/MT-ND3/PPIF/CBR1/MAPK1/SDHA/AKT2/HGF/MT-ATP8/SOS2/MT-ND4L/NCF1/NFE2L2/NDUFA6/SOS1/PIK3CA/MAP2K7/IKBKG/MAP2K1/PLD1/PLD2	2.86353360755101
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	27/1293	117/9376	1.67338925575584	ACTR6/RSF1/PHF10/KAT5/SMARCA2/BPTF/MCRS1/BAZ1B/INO80E/SMARCC1/SMARCE1/SMARCA1/EPC1/SMARCA4/RBBP7/MRGBP/PBRM1/GATAD2A/SMARCA5/BAZ2B/SMARCD1/BRD9/INO80/RBBP4/ING3/EPC2/DPF2	2.93140404504496
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	40/1293	193/9376	1.50287117960801	CCL4/CCL3/CXCL8/NFKBIA/CCL4L2/GNAI3/GNG5/PTK2/ROCK1/GNAI2/CCL3L1/GSK3A/CXCL2/PLCG2/MAPK3/GNG12/CCL2/PIK3R1/NRAS/RAP1B/CXCL3/MAPK1/SHC1/RAC3/AKT2/SOS2/CCL5/NCF1/TIAM1/CXCR4/GSK3B/SOS1/PIK3CA/GRK6/IKBKG/MAP2K1/CXCL1/ARRB2/ADCY7/CXCL16	2.82320048379314
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	15/1293	54/9376	2.01426484489129	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/HLA-G/HLA-DRB1/HLA-DPB1/CGA/HLA-DPA1/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB/HLA-F	2.98945702545798
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1293	50/9376	2.03037896365043	CXCL8/HBA2/HBA1/CCL2/GYPC/IL1B/ICAM1/ITGB2/CD36/HGF/PECAM1/TNF/CR1/MYD88	2.9216816394017
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/1293	275/9376	1.39753357238276	HSPA1A/MT-ATP6/HSPA1B/MT-ND1/ADRM1/C1QA/VDAC3/NDUFV1/MT-CO3/MT-ND2/MT-ND4/KLC1/EGR1/CYCS/C1QB/LAMC1/MT-CO1/PSMB4/NDUFA13/STIP1/SDHD/SLC25A6/MAPK3/SLC25A5/C1QC/PIK3R1/MT-CYB/TUBA1C/MT-ND3/PPIF/CREB1/IL1B/PRNP/MAPK1/BAX/TUBB/CYBB/SDHA/MT-ATP8/CCL5/MT-ND4L/CSNK2A2/NCF1/TNF/NDUFA6/HSPA6/GSK3B/CASP9/TUBB2A/PIK3CA/MCU/CREB3L2/ATF2	2.67604993084542
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	22/1293	93/9376	1.71537393242355	FOS/NFKBIA/HLA-DRA/JUN/RBPJ/HLA-DRB1/MAPK3/HLA-DPB1/HLA-DPA1/MAF/GATA3/MAPK1/IFNGR2/MAML2/JAK1/HLA-DMA/CD4/IFNGR1/IKBKG/HLA-DRB5/HLA-DQA1/HLA-DMB	2.77286688421023
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	32/1293	150/9376	1.54695540087651	RPS6KB2/GADD45G/CDH1/TGFBR2/EGFR/MAPK3/APC/DDB2/PIK3R1/NRAS/ERBB2/ARAF/RXRA/FZD1/MAPK1/BAX/SHC1/MLH1/DVL3/RPS6KB1/AKT2/HGF/SOS2/GAB1/GSK3B/POLK/SOS1/PIK3CA/CDK2/CTNNB1/MAP2K1/TGFBR1	2.70078137960717
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1293	99/9376	1.68465787027272	FOS/JUN/RPS6KB2/NCOR1/PTK2/EGFR/MAPK3/PIK3R1/NRAS/ERBB2/ARAF/IGF1R/MAPK1/BAX/SHC1/RPS6KB1/AKT2/SOS2/SOS1/PIK3CA/MMP2/MAP2K1/ADCY7	2.73896217727543
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	33/1293	157/9376	1.52416983167571	C1QA/STAB1/C1QB/PTK2/ADAM10/CAMK2D/CD47/MAPK3/TMEM30A/C1QC/DUSP2/DUSP7/RAB5C/ANO6/HIF1A/RXRA/CPT1A/CREB1/VPS16/MAPK1/PPARD/CD36/PECAM1/ABCA1/DUSP5/DOCK1/SGK1/ALOX5/CEBPB/PTGS2/MAP2K1/SIRPA/ADAM9	2.64897922133186
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1293	62/9376	1.87131701718933	HSPA1A/HSPA1B/SOD2/RPS6KB2/EIF4EBP2/PIK3R1/NRAS/IGF1R/PRKAA1/PRKAG2/RPS6KB1/AKT2/HSPA6/IRS2/PIK3CA/ADCY7	2.75297669704763
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	33/1293	158/9376	1.51452318717143	RPS6KB2/TNFRSF1A/EIF4B/EIF4EBP1/RHEB/LAMTOR3/MAPK3/EIF4E/PIK3R1/ATP6V1H/NRAS/IGF1R/PRKAA1/STK11/FZD1/MAPK1/ULK1/ATP6V1C1/DVL3/RPS6KB1/AKT2/SOS2/DDIT4/ATP6V1A/TNF/GSK3B/LPIN3/SGK1/SOS1/PIK3CA/SLC3A2/MAP2K1/TELO2	2.60863762547234
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1293	73/9376	1.78800495820488	GADD45G/CDH1/EGFR/MAPK3/DDB2/PIK3R1/NRAS/ARAF/IGF1R/MAPK1/BAX/PDGFB/AKT2/HGF/FGFR1/POLK/PIK3CA/MAP2K1	2.70319565651362
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1293	90/9376	1.69198246970869	FOS/NFKBIA/JUN/RPS6KB2/EGFR/MAPK3/PIK3R1/NRAS/HIF1A/MAPK1/RPS6KB1/AKT2/IFNGR2/CSNK2A2/JAK1/PIK3CA/CD4/IFNGR1/IKBKG/MAP2K1/MYD88	2.63815688663611
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/1293	136/9376	1.54624448387244	HSPA1A/FOS/NFKBIA/HSPA1B/JUN/CD46/CYCS/PIK3R1/TAB2/IFIH1/IL1B/BAX/IRAK1/AKT2/IRF3/EIF2AK2/CSNK2A2/JAK1/HSPA6/GSK3B/RCHY1/CASP9/PIK3CA/CDK2/IRF7/MAP3K7/IKBKG/TNFAIP3/MYD88	2.56636925728125
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1293	142/9376	1.5319760792131	FOS/JUN/HSP90AA1/TNFRSF1A/DUSP1/PTK2/CTSL/CALM3/CCL2/PIK3R1/HMOX1/THBD/IL1B/PRKAA1/ICAM1/RAC3/PDGFB/AKT2/PECAM1/NCF1/SQSTM1/NFE2L2/TNF/PIK3CA/MAP3K7/CTNNB1/MAP2K7/MMP2/IKBKG/IL1R2	2.55470026246196
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	17/1293	69/9376	1.78656534068619	PLCG2/MAPK3/FCER1G/PIK3R1/NRAS/GAB2/MAPK1/RAC3/AKT2/SOS2/TNF/ALOX5AP/SOS1/PIK3CA/ALOX5/MAP2K7/MAP2K1	2.62272710972298
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/1293	109/9376	1.59662828072117	NFKBIA/PYGL/RPS6KB2/TNFRSF1A/MLX/PYGB/PIK3R1/PTPA/PTPN1/OGA/CPT1A/CREB1/PRKAA1/CD36/PRKAG2/RPS6KB1/AKT2/SOCS3/TNF/GSK3B/GFPT1/IRS2/PIK3CA/CREB3L2	2.50579832251379
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	30/1293	144/9376	1.51069863366847	ADRM1/VDAC3/CYCS/BECN1/RB1CC1/KAT5/PSMB4/WIPI2/SLC25A6/RBPJ/SLC25A5/WIPI1/PIK3R1/PPIF/ULK1/NOP56/AKT2/AFG3L2/OPA1/PUM2/TBP/ATG13/ATXN2/PIK3C3/ATXN1/XBP1/PIK3CA/MCU/PUM1/GTF2B	2.46999830550913
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	45/1293	238/9376	1.3710542221529	FOS/RPS18/CXCL8/NFKBIA/RPS9/RPL7A/JUN/C1QA/F13A1/RPS25/RPS17/TNFRSF1A/C1QB/EGFR/PLCG2/MAPK3/RPL17/C5AR1/RPL22L1/CCL2/C1QC/PIK3R1/TAB2/IFIH1/CFD/FCGR2A/IL1B/RPS10/MAPK1/IRAK1/CYBB/IRF3/EIF2AK2/ISG15/JAK1/TNF/IL6ST/PIK3CA/RPS4Y1/C3AR1/MAP3K7/IKBKG/C2/NRP1/MYD88	2.31899007873813
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/1293	56/9376	1.81283836040217	MAN1A2/TUSC3/MAN1B1/RPN2/DDOST/ALG13/B4GALT3/MGAT2/ALG2/STT3A/STT3B/MAN1A1/MGAT1/ALG12	2.43999456921521
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	30/1293	148/9376	1.46986894086662	FOS/JUN/RPS6KB2/GADD45G/EGFR/MAPK3/APC/DDB2/PIK3R1/NRAS/ERBB2/ARAF/IGF1R/FZD1/MAPK1/BAX/NCOA1/SHC1/DVL3/RPS6KB1/AKT2/SOS2/FGFR1/GSK3B/POLK/SOS1/PIK3CA/BRCA1/CTNNB1/MAP2K1	2.30437107054534
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	82/1293	480/9376	1.23877287960815	MT-ATP6/MT-ND1/ADRM1/VDAC3/NDUFV1/MT-CO3/MT-ND2/TNFRSF1A/MT-ND4/KLC1/VCP/CYCS/GPX8/BECN1/RAB1A/ACTR1A/RB1CC1/MT-CO1/DCTN1/RAB8A/UBC/PSMB4/CAMK2D/NDUFA13/SDHD/UBA1/WIPI2/MAP1LC3B/SLC25A6/ATF6/TARDBP/CALM3/MAPK3/SLC25A5/APC/WIPI1/MT-CYB/NRAS/DNAL4/ARAF/TUBA1C/MT-ND3/PPIF/CDK5/IL1B/FZD1/MFN1/PRNP/MAPK1/BAX/TOMM40/TUBB/ULK1/CYBB/SDHA/DVL3/UBE2G2/MT-ATP8/MT-ND4L/CSNK2A2/ATG13/SQSTM1/ATXN2/TNF/NDUFA6/GSK3B/HTT/PIK3C3/CASP9/TUBB2A/ATXN1/XBP1/TANK/FUS/MCU/MFN2/DCTN5/CTNNB1/TNFRSF1B/MAP2K7/PTGS2/MAP2K1	2.14786430138827
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/1293	52/9376	1.81283836040217	APOE/VDAC3/PLTP/APOC1/APOC2/CD36/MYLIP/STARD3/ABCA1/LDLR/NCEH1/SCARB1/ANGPTL4	2.35073320414224
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1293	63/9376	1.72651272419254	ACAT1/KMT5B/NSD3/KMT2E/ASH1L/HADH/NSD1/PHYKPL/ALDH7A1/GCDH/KMT2A/PLOD1/EHMT1/KMT2C/SETD2	2.31402107219066
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	24/1293	115/9376	1.51332593564007	FOS/GNAI3/EGR1/AKAP13/NR4A2/GNAI2/EGFR/JUND/MAPK3/WNK1/ARAF/RXRA/CREB1/GATA3/MAPK1/FGFR1/SGK1/CREB3L2/MAP2K1/ARRB2/ADCY7/PLD1/PLD2/ATF2	2.2151941545889
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/1293	308/9376	1.2948845431444	MT-ATP6/MT-ND1/SOD2/ADRM1/VDAC3/NDUFV1/MT-CO3/MT-ND2/MT-ND4/KLC1/CYCS/GPX8/BECN1/ACTR1A/RB1CC1/POLR2H/AP2M1/MT-CO1/DCTN1/PSMB4/NDUFA13/SDHD/WIPI2/SLC25A6/REST/AP2B1/SLC25A5/WIPI1/MT-CYB/DNAL4/TUBA1C/POLR2B/MT-ND3/PPIF/CREB1/CLTC/BAX/TFAM/TUBB/ULK1/SDHA/POLR2A/MT-ATP8/TBP/MT-ND4L/ATG13/RCOR1/NDUFA6/HTT/PIK3C3/CASP9/TUBB2A/DCTN5/MAP2K7/CREB3L2	2.10460318187173
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1293	37/9376	1.95982525448883	UAP1/GALK1/GMPPB/GMPPA/PGM3/HK1/GNPNAT1/NAGK/UGDH/GFPT1	2.33959916816845
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	25/1293	122/9376	1.48593308229686	FOS/CSH1/JUNB/GNAI3/PTK2/GNAI2/PLCG2/MAPK3/PIK3R1/NRAS/CREB1/MAPK1/SHC1/AKT2/SOCS3/SOS2/GSK3B/IRS2/SOS1/PIK3CA/SOCS2/CREB3L2/MAP2K1/ADCY7/ATF2	2.16067897431524
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1293	70/9376	1.65745221522484	NFKBIA/TNFRSF1A/RXRA/CPT1A/PRKAA1/STK11/CD36/PRKAG2/AKT2/SOCS3/CAMKK2/ACSL1/TNF/IRS2/TNFRSF1B/IKBKG	2.20815878809079
NA	NA	hsa03272	Virion - Hepatitis viruses	12/1293	48/9376	1.81283836040217	TGOLN2/LAMP2/EGFR/CHMP1A/DPP4/IST1/HSPG2/CLDN15/LDLR/SCARB1/CLDN12/CLDN19	2.25802711304075
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1293	43/9376	1.85499739203943	ACADVL/ACAT1/ECI2/ADH5/ACADM/CPT1A/HADH/ACADSB/ALDH7A1/GCDH/ACSL1	2.24743425561335
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/1293	18/9376	2.41711781386955	HEXB/AGA/FUCA1/NEU1/MAN2B1/HEXA	2.40685152828623
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	31/1293	160/9376	1.40494972931168	HLA-A/HLA-B/HLA-DRA/HLA-E/HLA-C/CDH1/HLA-G/HLA-DRB1/VSIR/HLA-DPB1/CD58/HLA-DPA1/GLG1/ICAM1/ITGB2/SIGLEC1/PECAM1/PTPRM/CLDN15/HLA-DMA/ICAM3/CD4/HLA-DRB5/CLDN12/HLA-DQA1/F11R/NECTIN2/HLA-DMB/PTPRC/CLDN19/HLA-F	2.066276719261
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1293	71/9376	1.6341078178273	FOS/MAPK3/PIK3R1/CGA/NRAS/MAPK1/SHC1/AKT2/SOCS3/SOS2/IRF1/GSK3B/SOS1/PIK3CA/SOCS2/MAP2K1	2.14502671013941
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/1293	66/9376	1.64803487309288	HLA-DRA/JUN/HLA-DRB1/HLA-DPB1/HLA-DPA1/MAF/IL1B/GATA3/IFNGR2/TNF/HLA-DMA/IFNGR1/HLA-DRB5/HLA-DQA1/HLA-DMB	2.11297381925859
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1293	44/9376	1.81283836040217	PCNA/PARP1/PARP4/APTX/XRCC1/POLB/PARP2/NTHL1/OGG1/POLL/NEIL2	2.1614329887164
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1293	44/9376	1.81283836040217	RAB11B/DYNC1LI1/DYNLL2/DCTN1/DYNC1H1/RAB5C/ARHGDIB/CREB1/STX4/DCTN5/CREB3L2	2.1614329887164
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	28/1293	144/9376	1.40998539142391	REST/MAPK3/SMAD5/APC/PIK3R1/NRAS/BMI1/ZFHX3/IGF1R/FZD1/MAPK1/DVL3/PCGF5/PCGF1/AKT2/RIF1/FGFR1/ID3/JAK1/PCGF3/IL6ST/GSK3B/ID2/PIK3CA/TCF3/CTNNB1/MAP2K1/SMARCAD1	1.98289784882787
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1293	34/9376	1.91947591101406	FBXL3/CSNK1D/NR1D2/CREB1/PRKAA1/PRKAG2/BHLHE40/CUL1/SKP1	2.14811977983511
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/1293	19/9376	2.28990108682379	HEXB/GUSB/GALNS/NAGLU/HGSNAT/HEXA	2.25093785865317
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	37/1293	201/9376	1.3348262554205	FLT1/CXCL8/GADD45G/CD14/MAX/NCOR1/PTK2/KLF3/HPGD/TGFBR2/BCL2A1/DDB2/CSF1R/EWSR1/BMI1/RXRA/MAF/IGF1R/BIRC2/BAX/DDX5/NR4A3/SPI1/DUSP6/KMT2A/ELK4/ID2/POLK/TFE3/FUS/TCF3/PAX8/CEBPB/KDM6A/IL1R2/NUPR1/ZBTB17	1.91916851142517
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/1293	139/9376	1.4085362800247	HSPA1A/FOS/HSPA1B/JUN/GNAI3/HSP90AA1/GNAI2/EGFR/CALM3/MAPK3/PIK3R1/NRAS/CREB1/FKBP5/MAPK1/NCOA1/SHC1/AKT2/SOS2/HSPA6/SOS1/PIK3CA/MMP2/CREB3L2/MAP2K1/ADCY7/ATF2	1.94075703730418
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	26/1293	133/9376	1.41755781565282	HLA-A/HLA-B/HLA-E/HLA-C/TYROBP/HLA-G/PLCG2/MAPK3/TNFSF10/FCER1G/PIK3R1/NRAS/FCGR3A/ARAF/ICAM1/MAPK1/ITGB2/SHC1/RAC3/IFNGR2/SOS2/TNF/SOS1/PIK3CA/IFNGR1/MAP2K1	1.93970002871041
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	13/1293	57/9376	1.65381745159496	ACADVL/ELOVL5/ACAT1/MECR/ACADM/PPT1/CPT1A/HADH/HSD17B4/CBR4/ACADSB/ACSL1/ACSF3	1.98019469062961
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1293	122/9376	1.42649575900498	PFKL/NCOR1/RHEB/PLCG2/MAPK3/DIO2/PIK3R1/NRAS/HDAC3/HIF1A/RXRA/MAPK1/ATP1A1/NCOA1/THRA/AKT2/MED24/ATP1B1/PLCD3/GSK3B/CASP9/PIK3CA/CTNNB1/MAP2K1	1.89639366548361
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	47/1293	268/9376	1.27169258117764	MT-ATP6/MT-ND1/ADRM1/VDAC3/GNAI3/NDUFV1/MT-CO3/MT-ND2/MT-ND4/KLC1/CYCS/DUSP1/SLC39A8/MT-CO1/UBC/PSMB4/CAMK2D/NDUFA13/GNAI2/SDHD/UBA1/SLC25A6/ATF6/CALM3/SLC39A13/SLC39A3/SLC25A5/MT-CYB/TUBA1C/MT-ND3/PPIF/MFN1/BAX/TUBB/SDHA/UBE2G2/MT-ATP8/MT-ND4L/SLC39A14/NFE2L2/NDUFA6/CASP9/TUBB2A/XBP1/MCU/MFN2/SLC39A7	1.80481327644542
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1293	75/9376	1.54695540087651	SERPINE1/GADD45G/CYCS/SHISA5/DDB2/RRM2B/CCNG2/BAX/CD82/COP1/ZMAT3/SESN3/GORAB/RCHY1/CASP9/CDK2	1.90202550319734
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1293	20/9376	2.1754060324826	UAP1/GMPPB/GMPPA/CYB5R4/UGDH/CYB5R2	2.10453628420482
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1293	100/9376	1.45027068832173	CCL4/CCL3/CXCL8/CCL4L2/TNFRSF1A/CCL3L1/CXCL2/LTBR/TNFSF10/CCL2/CSF1R/CXCL3/CCL5/TNFRSF14/CXCR4/TNF/IL6ST/IL10RA/TNFRSF1B/CXCL1	1.8104724372678
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1293	88/9376	1.48323138578359	SERPINE2/SERPINE1/C1QA/F13A1/CD46/C1QB/TFPI/C5AR1/C1QC/PLAUR/THBD/CFD/ITGB2/VSIG4/A2M/C3AR1/C2/CR1	1.82152014148139
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	21/1293	108/9376	1.40998539142391	RNPS1/UPF2/THOC2/NUP42/XPO1/KPNB1/KPNA6/RBM8A/UPF3B/TMEM33/TNPO1/NCBP2/CASC3/AAAS/KPNA1/DDX39B/IPO8/XPOT/XPO6/PNN/THOC1	1.71390149917629
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/1293	91/9376	1.43433364779072	FOS/NFKBIA/JUN/PLCG2/MAPK3/PIK3R1/NRAS/MAPK1/RAC3/AKT2/MALT1/SOS2/GSK3B/SOS1/PIK3CA/LILRB5/IKBKG/MAP2K1	1.66514412255236
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	36/1293	205/9376	1.27340840925811	MT-ATP6/MT-ND1/VDAC3/NDUFV1/MT-CO3/MT-ND2/MT-ND4/MT-CO1/CAMK2D/NDUFA13/SDHD/TGFBR2/SLC25A6/SLC25A5/PARP1/PIK3R1/PTPA/MT-CYB/MT-ND3/PPIF/COL1A1/CD36/CYBB/SDHA/AKT2/MT-ATP8/MT-ND4L/NCF1/NDUFA6/GSK3B/COL3A1/GFPT1/PIK3CA/MMP2/PDK4/TGFBR1	1.58299325048283
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1293	110/9376	1.38434929339802	RPS6KB2/NCOR1/ROCK1/TFDP1/TGFBR2/MAPK3/SMAD5/LTBP1/FBN1/MAPK1/SMURF2/RPS6KB1/CUL1/NOG/SKP1/ID3/TNF/ID2/DCN/TGIF1/TGFBR1	1.62171634111104
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/1293	105/9376	1.38121017935403	NFKBIA/JUN/CYLD/CALM3/PLCG2/MAPK3/FCER1G/PIK3R1/NRAS/IL1B/MAPK1/AKT2/MALT1/LSP1/IRF1/TNF/PIK3CA/PLK3/PTGS2/IKBKG	1.57106610565946
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/1293	99/9376	1.39167389283399	HLA-DRA/C1QA/C1QB/HLA-DRB1/C5AR1/HLA-DPB1/C1QC/FCGR3A/CFD/HLA-DPA1/FCGR2A/ICAM1/ITGB2/HLA-DMA/C3AR1/HLA-DRB5/HLA-DQA1/C2/HLA-DMB	1.56688475350644
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1293	75/9376	1.45027068832173	CYCS/MAPK3/TOP2B/PIK3R1/ERBB2/BIRC2/MSH3/MAPK1/BAX/MLH1/AKT2/MSH2/CASP9/PIK3CA/BRCA1	1.56580651943047
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1293	23/9376	1.89165741955009	FNTA/PCYOX1/ACAT1/ZMPSTE24/IDI1/HMGCS1	1.71232063282712
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1293	23/9376	1.89165741955009	PCNA/RPA2/PMS2/MSH3/MLH1/MSH2	1.71232063282712
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/1293	100/9376	1.37775715390565	HLA-DRA/CD14/ITGA5/HLA-DRB1/HLA-DPB1/CSF1R/HLA-DPA1/IL1B/CD36/CSF3R/TNF/HLA-DMA/CD4/IL1R2/HLA-DRB5/HLA-DQA1/CD44/HLA-DMB/CR1	1.5189061443818
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	28/1293	157/9376	1.29323500869454	FOS/CXCL8/JUN/NDUFV1/MT-CO3/TNFRSF1A/CYCS/MT-CO1/NDUFA13/SDHD/MLX/GSK3A/PIK3R1/MT-CYB/RXRA/IL1B/PRKAA1/BAX/SDHA/PRKAG2/AKT2/SOCS3/TNF/NDUFA6/GSK3B/IRS2/XBP1/PIK3CA	1.48191177373877
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	40/1293	235/9376	1.23427292623126	MT-ATP6/MT-ND1/NDUFV1/MT-CO3/RPS6KB2/MT-ND2/MT-ND4/MT-CO1/SMARCA2/NDUFA13/RHEB/SDHD/PNPLA2/SMARCC1/SMARCE1/MT-CYB/NRAS/SMARCA4/MT-ND3/CPT1A/CREB1/PRKAA1/SIRT6/SMARCD1/SDHA/PRKAG2/RPS6KB1/MT-ATP8/SOS2/FGFR1/MT-ND4L/ACSL1/NDUFA6/SOS1/COX19/CREB3L2/KDM3A/NDUFAF7/ADCY7/ATF2	1.45464758449282
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/1293	170/9376	1.27965060734271	JUN/AFDN/ACTR3/PCNA/ROCK1/RAB8A/HSPA4/ARPC5/PPP2R2D/ACTR2/ERBB2/DLG1/TUBA1C/PRKAA1/STK11/VASP/PRKAG2/AMOTL2/ACTN1/TIAM1/CLDN15/MAP2K7/MICALL2/CLDN12/F11R/ACTN4/CLDN19/MYH10/WHAMM/MYH9	1.47164599720341
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1293	29/9376	1.75032669280209	MOB1A/TEAD1/RASSF1/TEAD3/LATS1/RASSF4/SAV1	1.61849695085431
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	25/1293	140/9376	1.2948845431444	SPP1/SERPINE1/GNAI3/RPS6KB2/CDH1/EGR1/GNG5/BECN1/GNAI2/MAP1LC3B/CALM3/MAPK3/GNG12/NRAS/PRKAA1/MAPK1/TFAM/PRKAG2/RPS6KB1/AKT2/PIK3C3/CCN2/MAP2K1/TGFBR1/ADCY7	1.40595906377363
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1293	78/9376	1.3944910464632	IP6K2/ITPKC/PPIP5K2/PLCG2/SACM1L/PI4KA/PIP4K2C/PLCD3/MINPP1/PIK3C3/PIK3CA/PIK3C2A/ALDH6A1/MTMR14/MTM1	1.39922737221716
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1293	60/9376	1.45027068832173	PTK2/PLCG2/MAPK3/PIK3R1/NRAS/MAPK1/RAC3/AKT2/CASP9/PIK3CA/PTGS2/MAP2K1	1.39937197695588
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	29/1293	168/9376	1.25172172503959	FTL/VDAC3/HSP90AA1/PYGL/TNFRSF1A/CYLD/CAMK2D/DNM1L/SLC25A6/CHMP1A/GLUL/SLC25A5/TNFSF10/PARP1/PYGB/FTH1/IL1B/BIRC2/BAX/CYBB/IFNGR2/CFLAR/EIF2AK2/SQSTM1/JAK1/TNF/TRPM7/IFNGR1/TNFAIP3	1.3167135235287
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1293	54/9376	1.47712755292028	RPA2/FANCL/PMS2/RAD51C/MLH1/POLI/REV1/RMI1/POLK/BRCA1/TELO2	1.4062917809894
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/1293	93/9376	1.32551622050911	JUN/EGR1/CAMK2D/EGFR/CALM3/MAPK3/CGA/NRAS/MAPK1/SOS2/SOS1/MAP2K7/MMP2/MAP2K1/ADCY7/PLD1/PLD2	1.26173614554992
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1293	32/9376	1.58623356535189	TNFRSF1A/CYCS/BECN1/BIRC6/BIRC2/BAX/CASP9	1.32854988539014
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1293	50/9376	1.45027068832173	AOC1/SAT1/SRM/GOT2/OAT/GAMT/ALDH7A1/AMD1/PYCR1/L3HYPDH	1.27676092897864
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/1293	50/9376	1.45027068832173	HLA-DRA/LTBR/HLA-DRB1/HLA-DPB1/HLA-DPA1/CXCR4/HLA-DMA/HLA-DRB5/HLA-DQA1/HLA-DMB	1.27676092897864
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	38/1293	232/9376	1.18772168440142	FN1/ACTR3/VCL/PTK2/ROCK1/ITGA5/ARPC5/EGFR/MAPK3/ACTR2/APC/GNG12/PIK3R1/NRAS/ARAF/IQGAP1/PPP1R12A/MAPK1/ITGB2/RAC3/PDGFB/AKT2/CYFIP1/ARHGAP35/SOS2/ACTN1/FGFR1/TIAM1/PIP4K2C/CXCR4/DOCK1/SOS1/PIK3CA/MAP2K1/ACTN4/MYH10/SCIN/MYH9	1.1579476812749
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1293	63/9376	1.38121017935403	PCNA/RPA2/POLR2H/DDB2/XPC/CCNH/POLR2B/POLR2A/ERCC3/POLR2M/CUL4B/ERCC8	1.21419537275032
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1293	21/9376	1.72651272419254	CHPF/B4GALT7/CSGALNACT2/CHST14/CHPF2	1.33299827576288
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	14/1293	76/9376	1.33577563398054	PLTP/ILK/UBC/PLIN2/OLR1/ACADM/RXRA/CPT1A/PPARD/HMGCS1/CD36/ACSL1/ANGPTL4/ME3	1.17547422560571
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1293	51/9376	1.42183400815856	PAFAH1B1/CHPT1/PAFAH1B3/PLD3/PLPP1/CEPT1/LPCAT1/ENPP2/PLD1/PLD2	1.20809439271165
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1293	27/9376	1.61141187591304	ACAT1/AACS/HADH/OXCT1/HMGCS1/ABAT	1.27242379934212
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/1293	89/9376	1.30361410186223	SPP1/FN1/COL4A1/LAMA3/LAMC1/COL4A2/ITGA5/CD47/DAG1/LAMB2/COL1A1/CD36/HSPG2/LAMA5/CD44/COL6A1	1.1510066452703
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1293	89/9376	1.30361410186223	GNAI3/GNAI2/EGFR/MAPK3/NRAS/CSNK1D/TUBA1C/MAPK1/TUBB/PDGFB/SOS2/GUCY1B1/TUBB2A/SOS1/MAP2K1/ADCY7	1.1510066452703
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	26/1293	155/9376	1.21635606117307	GNAI3/NR4A1/USP8/CAMK2D/GNAI2/EGFR/MAPK3/APC/RAP1B/CREB1/FZD1/MAPK1/DVL3/ASH2L/KMT2A/GSK3B/LDLR/CDK2/NCEH1/CTNNB1/SCARB1/CREB3L2/MAP2K1/CYP11A1/ADCY7/ATF2	1.08628683364355
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1293	149/9376	1.21667004053837	CXCL8/CYTH2/RHEB/EGFR/PLCG2/MAPK3/FCER1G/PIK3R1/NRAS/GAB2/PLPP1/MAPK1/SHC1/PDGFB/AKT2/SOS2/GAB1/LPAR6/SOS1/PIK3CA/DNM2/MAP2K1/ADCY7/PLD1/PLD2	1.06625320529279
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1293	34/9376	1.49292570856649	POLR2H/POLR2B/POLR2A/POLR2M/POLR1E/CRCP/POLR3B	1.15159456803292
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1293	59/9376	1.35194725182534	TK2/UMPS/RRM2B/TYMP/UPP1/DCK/CDADC1/NT5C2/UCKL1/CANT1/ENTPD4	1.084586383322
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1293	59/9376	1.35194725182534	GNAI3/GNAI2/PNPLA2/PIK3R1/CGA/ABHD5/AKT2/IRS2/PIK3CA/PTGS2/ADCY7	1.084586383322
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	13/1293	72/9376	1.30927214917934	CXCL8/NFKBIA/CYLD/ATG12/IFIH1/IRF3/ISG15/TNF/TANK/NLRX1/IRF7/MAP3K7/IKBKG	1.05358801312519
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1293	47/9376	1.38855704201017	MAPK3/PIK3R1/HK1/MAPK1/SOCS3/TNF/IRS2/PIK3CA/SOCS2	1.06803326135247
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/1293	138/9376	1.20855890693478	MT-ATP6/MT-ND1/NDUFV1/MT-CO3/MT-ND2/MT-ND4/CYCS/ATP6V0C/MT-CO1/ATP6V0B/NDUFA13/SDHD/ATP6V0D1/ATP6V1H/MT-CYB/MT-ND3/SDHA/ATP6V1C1/MT-ATP8/MT-ND4L/ATP6V1A/NDUFA6/TCIRG1	0.987138106939838
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1293	17/9376	1.70620080979027	LAMP2/DAG1/MYH10/MYH9	1.16556516561725
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1293	54/9376	1.34284322992753	SRM/GOT2/GSS/TST/LDHA/LACC1/SDSL/AMD1/GCLM/MAT2B	1.01050046987225
Organismal Systems	Immune system	hsa04611	Platelet activation	21/1293	126/9376	1.20855890693478	GNAI3/ROCK1/GNAI2/PLCG2/MAPK3/FCER1G/PIK3R1/FCGR2A/RAP1B/PPP1R12A/COL1A1/MAPK1/VASP/AKT2/ARHGAP35/GUCY1B1/TLN2/COL3A1/PIK3CA/ADCY7/FERMT3	0.942631089602143
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1293	55/9376	1.3184278984743	SPTLC1/PSAP/HEXB/CERS5/PLPP1/ARSA/CERK/SGMS1/NEU1/HEXA	0.947239527823968
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1293	30/9376	1.45027068832173	ACO2/SDHD/IDH2/SDHA/IDH1/CS	0.987916016567825
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1293	30/9376	1.45027068832173	IL1B/FOLR2/GGH/TNF/IKBKG/GART	0.987916016567825
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/1293	62/9376	1.28653044931767	APH1A/TLE1/RBPJ/NCSTN/CTBP2/DVL3/APH1B/TLE4/MAML2/ATXN1/CTBP1	0.905309588134345
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1293	18/9376	1.61141187591304	MECR/CBR4/ACSL1/ACSF3	1.03842996930183
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	37/1293	238/9376	1.12731124932572	FLT1/AFDN/GNG5/EGFR/CALM3/PLCG2/MAPK3/GNG12/CSF1R/PIK3R1/RAB5C/NRAS/GAB2/RAP1B/IGF1R/MAPK1/SHC1/RAC3/PDGFB/AKT2/HGF/SOS2/RASA2/FGFR1/STK4/TIAM1/RALGAPA1/RASSF1/GAB1/SOS1/PIK3CA/RALGAPB/IKBKG/MAP2K1/PLD1/PLD2/NTF4	0.795661405993751
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1293	37/9376	1.37187767814218	HBA2/HBA1/IL1B/ICAM1/THOP1/TNF/MYD88	0.906461569304316
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1293	116/9376	1.18772168440142	PFKL/ACO2/GOT2/ACAT1/SDHD/PGD/HK1/ADH5/IDH2/TKT/SDSL/SDHA/PRPS1/ALDH6A1/ME3/IDH1/CS/ACSS2/ME2	0.813647988168809
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/1293	157/9376	1.15467411490584	SERPINE1/CDH1/MOB1A/TGFBR2/YWHAG/PPP2R2D/APC/CSNK1D/DLG1/TEAD1/YWHAE/BIRC2/FZD1/ITGB2/DVL3/RASSF1/GSK3B/ID2/TP53BP2/CTNNB1/TEAD3/LATS1/SAV1/CCN2/TGFBR1	0.781671305182922
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1293	31/9376	1.403487762892	ACO2/ACAT1/GLUL/AFMID/CS/ACSS2	0.899953713071297
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	18/1293	110/9376	1.18658510862687	GNAI3/HSP90AA1/CDC25B/GNAI2/MAPK3/PIK3R1/ARAF/IGF1R/MAPK1/AKT2/CDC23/ANAPC4/ANAPC7/PIK3CA/CDK2/CPEB2/MAP2K1/ADCY7	0.787273776394919
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1293	13/9376	1.67338925575584	PRKDC/MRE11/POLL	0.971692741171006
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1293	38/9376	1.33577563398054	PNP/BST1/SIRT5/NADSYN1/SIRT6/NT5C2/NADK	0.82949286078148
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1293	38/9376	1.33577563398054	MAPK3/PIK3R1/MAPK1/ATP1A1/ATP1B1/SGK1/PIK3CA	0.82949286078148
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1293	51/9376	1.27965060734271	ATP6V0C/ATP6V0B/ATP6V0D1/PLCG2/ATP6V1H/ATP6V1C1/ATP6V1A/PDIA4/TCIRG1	0.800894010712716
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/1293	98/9376	1.18389443944631	IP6K2/ITPKC/PPIP5K2/CALM3/PLCG2/PIK3R1/SACM1L/PI4KA/PIP4K2C/PLCD3/PIK3C3/PIK3CA/PIK3C2A/MTMR14/PIP4P2/MTM1	0.731902216438205
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1293	32/9376	1.35962877030162	ECHDC1/LDHA/DBT/ABAT/ALDH6A1/ACSS2	0.815007515443821
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1293	85/9376	1.19434056685319	PNP/HPRT1/TK2/RRM2B/TYMP/LACC1/UPP1/IMPDH1/DCK/NT5C2/UCKL1/AMPD3/CANT1/ENTPD4	0.719847182591234
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/1293	79/9376	1.19326069292294	ATP6V0C/AP2M1/ATP6V0B/ATP6V0D1/AP2B1/ATP6V1H/CLTC/ATP6V1C1/ATP6V1A/DNM2/STX2/STX3/TCIRG1	0.689897027503786
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	24/1293	154/9376	1.13008105583512	GMPPB/GSS/GMPPA/FLAD1/UMPS/COASY/PDXK/RDH11/NADSYN1/GUSB/COQ2/MTHFD2/GGCX/UGDH/PANK3/AFMID/GGH/NADK/GCLM/MAT2B/MTHFD2L/NFS1/HMBS/PHOSPHO2	0.65096923780869
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1293	33/9376	1.3184278984743	ACO2/GOT2/IDH2/DBT/IDH1/CS	0.732864217259268
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1293	107/9376	1.15208419165745	PYGL/PFKL/PRMT1/CAMK2D/CALM3/PHKB/PYGB/LDHA/PPP4R3A/CPT1A/CREB1/PRKAA1/PRKAG2/AKT2/PHKA1/CREB3L2/ATF2	0.632787851473881
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	54/1293	368/9376	1.06405729849692	MT-ATP6/MT-ND1/ADRM1/NDUFV1/MT-CO3/MT-ND2/TNFRSF1A/MT-ND4/KLC1/VCP/CYCS/GPX8/BECN1/RAB1A/ACTR1A/RB1CC1/MT-CO1/DCTN1/RAB8A/PSMB4/NDUFA13/SDHD/WIPI2/MAP1LC3B/ATF6/TARDBP/UBQLN1/WIPI1/MT-CYB/DNAL4/TUBA1C/MT-ND3/BAX/TOMM40/TUBB/ULK1/SDHA/SRSF7/MT-ATP8/MT-ND4L/ATG13/SQSTM1/ATXN2/TNF/NDUFA6/PIK3C3/CASP9/TUBB2A/XBP1/TANK/FUS/MCU/DCTN5/TNFRSF1B	0.501391481261689
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1293	75/9376	1.16021655065739	PFKL/ACO2/GOT2/GLUL/IDH2/TKT/SDSL/MAT2B/PRPS1/PYCR1/IDH1/CS	0.557149568129881
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1293	75/9376	1.16021655065739	GPX8/TTF1/CANX/CGA/CREB1/ATP1A1/ATP1B1/PDIA4/PAX8/CREB3L2/ADCY7/ATF2	0.557149568129881
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1293	28/9376	1.2948845431444	ATP6V0C/ATP6V0D1/ATP6V1C1/ATP6V1A/TCIRG1	0.624985992669235
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1293	83/9376	1.13575415350497	SOD2/ECI2/IDH2/HSD17B4/PEX13/CRAT/PXMP2/ACSL1/PXMP4/PEX14/ECH1/MPV17L2/IDH1	0.496835723443078
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1293	83/9376	1.13575415350497	CCL4/NFKBIA/CCL4L2/POLR2H/G3BP1/DNASE2/DDX41/IL1B/IRF3/CCL5/IRF7/IKBKG/POLR3B	0.496835723443078
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1293	49/9376	1.18389443944631	FOSB/JUN/GNAI3/GNAI2/CDK5/CREB1/CREB3L2/ATF2	0.516171783557824
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1293	36/9376	1.20855890693478	PCNA/RPA2/RNASEH2C/RNASEH2B/RNASEH1/PRIM2	0.501424055959755
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1293	16/9376	1.35962877030162	HEXB/HEXA/NAGA	0.575804568381894
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	31/1293	212/9376	1.06033941834844	FLT1/GNAI3/AFDN/CDH1/GNAI2/EGFR/CALM3/MAPK3/RGS14/CSF1R/PIK3R1/NRAS/RAP1B/IGF1R/MAPK1/ITGB2/VASP/SIPA1/RAC3/PDGFB/AKT2/HGF/FGFR1/KRIT1/TIAM1/TLN2/FYB1/PIK3CA/CTNNB1/MAP2K1/ADCY7	0.355406299123849
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1293	23/9376	1.26110494636672	THOP1/LNPEP/PREP/NLN	0.501420587317666
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1293	65/9376	1.11559283717056	SPP1/MAPK3/PIK3R1/CGA/NRAS/MAPK1/AKT2/PIK3CA/MAP2K1/ARRB2	0.374014164266626
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1293	101/9376	1.07693367944683	GNAI3/CAMK2D/GNAI2/CALM3/MAPK3/NRAS/CREB1/FZD1/MAPK1/DVL3/GSK3B/CTNNB1/CREB3L2/MAP2K1/ADCY7	0.310898654548263
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1293	73/9376	1.09266969668076	XPO1/CPSF6/NELFB/NELFCD/HGS/SUPT5H/BICD2/NELFA/CXCR4/CD4/CPSF7	0.317896884974585
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1293	59/9376	1.10613866058437	SRM/GPX8/GSS/PGD/RRM2B/IDH2/GCLM/IDH1/GGT7	0.327084656626251
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1293	52/9376	1.11559283717056	CGA/IGF1R/LDLR/ALOX5/SCARB1/PTGS2/CYP11A1/ADCY7	0.334295148623902
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/1293	166/9376	1.0483884493892	VDAC3/GNAI3/ROCK1/GNAI2/SLC25A6/CALM3/MAPK3/SLC25A5/GTF2I/PPIF/CREB1/PPP1R12A/MAPK1/ATP1A1/VASP/AKT2/ATP1B1/GUCY1B1/IRS2/CREB3L2/MAP2K1/RGS2/ADCY7/ATF2	0.251573299341267
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/1293	138/9376	1.05092078863894	PPP2R5C/PPP2R5E/CAMK2D/CALM3/YWHAG/MAPK3/SMC1A/YWHAE/IGF1R/MAPK1/CDC23/CUL1/ANAPC4/SKP1/ANAPC7/PPP2R5D/CDK2/CPEB2/MAP2K1/ADCY7	0.241015124406282
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1293	60/9376	1.0877030162413	GNAI3/GNAI2/MAPK3/NRAS/ARAF/IGF1R/MAPK1/GUCY1B1/MAP2K1	0.272567471980071
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1293	39/9376	1.11559283717056	MTHFD2/MTHFS/ALDH7A1/MAT2B/MTHFD2L/GART	0.289306478340028
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	19/1293	133/9376	1.03590763451552	FOS/GNAI3/PPP2R5C/GNG5/PPP2R5E/CAMK2D/GNAI2/CALM3/GSK3A/PPP2R2D/GNG12/CREB1/AKT2/PPP2R3C/PPP2R5D/GSK3B/CREB3L2/ARRB2/ATF2	0.166803343368847
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1293	47/9376	1.07998881045235	ACAT1/ADH5/LDHA/ALDH7A1/ME3/ACSS2/ME2	0.219866585500968
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1293	12/9376	1.20855890693478	COQ2/GGCX	0.289126083809059
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/1293	63/9376	1.03590763451552	GADD45G/APC/DDB2/FZD1/BAX/DVL3/GSK3B/POLK/CTNNB1	0.114369673309976
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	30/1293	217/9376	1.00249125920857	FOS/JUN/GNAI3/HSP90AA1/RPS6KB2/EIF4EBP1/GNAI2/EGFR/MAPK3/PAQR7/KPNB1/KPNA6/PIK3R1/NRAS/RXRA/CREB1/MAPK1/RPS6KB1/AKT2/SOS2/KPNA1/SOS1/PIK3CA/CREB3L2/MAP2K1/KLF5/ARRB2/ADCY7/ATF2/PAQR8	0.0148498944118556
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1293	115/9376	1.00888395709338	FOS/GNAI3/GNG5/CAMK2D/GNAI2/MAPK3/GNG12/PIK3R1/NRAS/CREB1/MAPK1/AKT2/PIK3CA/CREB3L2/MAP2K1/ADCY7	0.0383376105832899
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1293	42/9376	1.03590763451552	AOC1/ACAT1/HADH/ALDH7A1/GCDH/AFMID	0.0932773403180067
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1293	35/9376	1.03590763451552	PFKL/GMPPB/GMPPA/HK1/ENOSF1	0.0851182612407025
NA	NA	hsa04517	IgSF CAM signaling	41/1293	299/9376	0.994332746173763	AFDN/ACTR3/CDH1/SPTAN1/VCL/DYNLL2/EPB41L2/PTK2/ITGA5/ARPC5/PLCG2/MAPK3/ACTR2/PIK3R1/IQGAP1/TUBA1C/NCK2/RAP1B/ICAM1/MAPK1/ITGB2/TUBB/AKT2/ACTN1/FGFR1/PMP22/ICAM3/GSK3B/TUBB2A/PIK3CA/ERC1/CTNNB1/TRIO/NCK1/MAP2K1/F11R/ACTN4/NECTIN2/NRP1/MYH10/MYH9	-0.0398323291509223
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1293	65/9376	1.00403355345351	NR4A1/CREB1/LDLR/NCEH1/SCARB1/CREB3L2/CYP11A1/ADCY7/ATF2	0.0130510346563446
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1293	28/9376	1.03590763451552	ELOVL5/MECR/PPT1/HADH	0.0761035772264899
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1293	43/9376	1.01181675929423	GOT2/ACAT1/PLPP1/CD36/ABCA1/SCARB1	0.0310613691637664
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	21/1293	154/9376	0.988820923855727	FOS/JUN/GNAI3/ROCK1/CAMK2D/GNAI2/EGFR/CALM3/MAPK3/NRAS/PRKAA1/PPP1R12A/MAPK1/EEF2/PRKAG2/CAMKK2/GUCY1B1/PTGS2/MAP2K1/RGS2/ADCY7	-0.0559438469369992
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1293	36/9376	1.00713242244565	PYGL/PYGB/HK1/GBE1/AGL	0.0171480002656201
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1293	104/9376	0.976143732524243	CHPT1/LYPLA2/PLD3/PLPP1/CEPT1/GPAT4/LPCAT1/LPGAT1/SGMS1/LPIN3/LCLAT1/PLD1/PLD2/MBOAT1	-0.0978432939051462
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1293	97/9376	0.971830873617656	FOS/GNAI3/GNG5/CAMK2D/GNAI2/CALM3/MAPK3/GNG12/CREB1/MAPK1/RPS6KA5/GUCY1B1/ADCY7	-0.111533997816878
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1293	37/9376	0.979912627244414	GOT2/MIF/ADH5/PNMT/FAH	-0.0489634966051062
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1293	14/9376	1.03590763451552	B4GALT3/B3GNT2	0.0537731040423705
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1293	98/9376	0.961914232050129	NR4A1/CAMK2D/NR4A2/CALM3/CREB1/ATP1A1/ATP1B1/LDLR/SCARB1/CREB3L2/CYP11A1/ADCY7/ATF2	-0.151581842611397
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1293	30/9376	0.966847125547821	MPPE1/PIGQ/PIGS/PIGN	-0.0727390356868329
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/1293	233/9376	0.964772346308449	FN1/FBLN1/COL4A1/SPTAN1/VCL/CAPZA1/EMD/SUN2/COL4A2/PDLIM5/ITGA5/FBN1/SYNE2/DAG1/INF2/PKP2/COL1A1/ATP1A1/FBN2/HSPG2/ATP1B1/BGN/TLN2/SYNE1/COL3A1/AMPD3/DCN/ZYX/COL6A1/MYH10/MYH9	-0.21777896535743
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1293	61/9376	0.950997172669989	FTL/MT2A/HMOX1/FTH1/ATP1A1/ATP1B1/SLC30A1/TRPM7	-0.153565351265052
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1293	46/9376	0.945828709775043	ADRM1/PSMB4/PSME1/PSMB8/PSME2/PSMB9	-0.147301064283418
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1293	15/9376	0.966847125547821	HEXB/HEXA	-0.0513930399186444
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1293	31/9376	0.935658508594666	PFKL/PGD/TKT/PRPS1	-0.143509591665793
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1293	24/9376	0.906419180201083	B4GALT7/HS2ST1/EXT2	-0.18358569098604
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1293	48/9376	0.906419180201083	PIK3R1/HK1/ATP1A1/AKT2/ATP1B1/PIK3CA	-0.259963159541323
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	23/1293	178/9376	0.936972635713479	NOTUM/JUN/CAMK2D/TLE1/APC/CELSR1/APCDD1/CTBP2/FZD1/TBL1XR1/PPARD/DVL3/RAC3/CUL1/SKP1/TLE4/CSNK2A2/SFRP1/GSK3B/CHD8/MAP3K7/CTNNB1/CTBP1	-0.339540087089809
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1293	16/9376	0.906419180201083	GOT2/MIF	-0.14983301671873
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/1293	56/9376	0.906419180201083	CSNK1D/CSNK1G2/SMURF2/CUL1/CSNK1G3/GSK3B/ARRB2	-0.280912790556651
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1293	41/9376	0.88431139531813	RPA2/MRE11/RAD51C/TOPBP1/BRCA1	-0.296909409701286
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/1293	143/9376	0.912757775866825	HLA-DRA/C1QA/SNRPD3/C1QB/HLA-DRB1/HLA-DPB1/C1QC/FCGR3A/HLA-DPA1/FCGR2A/ACTN1/TNF/HLA-DMA/HLA-DRB5/HLA-DQA1/ACTN4/C2/HLA-DMB	-0.420457342521717
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	16/1293	128/9376	0.906419180201083	PNP/NUDT5/HPRT1/RRM2B/LACC1/IMPDH1/DCK/NT5C2/FHIT/GUCY1B1/PRPS1/AMPD3/CANT1/GART/ADCY7/ENTPD4	-0.426350258820538
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1293	82/9376	0.88431139531813	HPRT1/TK2/UMPS/RRM2B/TYMP/UPP1/GUSB/IMPDH1/CDADC1/UCKL1	-0.420818463617923
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1293	67/9376	0.865833246759243	CAMK2D/CALM3/MAPK3/NRAS/ARAF/RAP1B/MAPK1/MAP2K1	-0.440787639568203
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1293	18/9376	0.805705937956518	TCN2/ZNF143	-0.329991589682563
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	19/1293	154/9376	0.894647502536134	GNAI3/PPP2R5C/PPP2R5E/CAMK2D/GNAI2/CALM3/MAPK3/PPP2R2D/CREB1/MAPK1/ATP1A1/AKT2/PPP2R3C/ATP1B1/RPS6KA5/PPP2R5D/CREB3L2/ADCY7/ATF2	-0.527219236767459
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1293	69/9376	0.840736630911149	FOS/FOSB/JUN/CAMK2D/CALM3/CREB1/CREB3L2/ATF2	-0.531048514457483
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1293	53/9376	0.820907936785886	AP2M1/AP2B1/CLTC/ATP1A1/ATP1B1/DNM2	-0.522919748542492
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1293	37/9376	0.783930101795531	GOT2/GLUL/GFPT1/ABAT	-0.526676029559817
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1293	10/9376	0.725135344160866	TST	-0.34780869356937
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1293	46/9376	0.788190591479202	FTL/HMOX1/FTH1/GUSB/HMBS	-0.575946247002638
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1293	63/9376	0.805705937956518	HPGD/PTGR1/CBR1/LTA4H/PTGDS/ALOX5/PTGS2	-0.618847459650253
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1293	20/9376	0.725135344160866	SC5D/CYP51A1	-0.492138567842079
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/1293	168/9376	0.863256362096269	CSH1/EGFR/MCL1/PIK3R1/PDGFB/PTPN2/AKT2/IFNGR2/SOCS3/SOS2/PIM1/JAK1/CSF3R/IL6ST/STAM2/SOS1/PIK3CA/SOCS2/IL10RA/IFNGR1	-0.715282708538706
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	22/1293	184/9376	0.867009650627123	GNAI3/ILK/PTK2/ROCK1/EFNB2/CAMK2D/GNAI2/PLCG2/MAPK3/PIK3R1/NRAS/NCK2/CDK5/MAPK1/SEMA4D/EPHB4/RAC3/CXCR4/GSK3B/PIK3CA/NCK1/NRP1	-0.728656161841435
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1293	21/9376	0.690605089677015	COASY/PANK3	-0.567674685186999
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1293	65/9376	0.780914986019394	PNPLA2/PLPP1/GPAT4/ALDH7A1/LPIN3/LCLAT1/MBOAT1	-0.708875224564218
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	27/1293	226/9376	0.866312136829353	FOS/NFKBIA/JUN/GNAI3/AFDN/ROCK1/CAMK2D/GNAI2/CALM3/MAPK3/PIK3R1/CGA/RAP1B/CREB1/PPP1R12A/MAPK1/ATP1A1/RAC3/AKT2/ATP1B1/TIAM1/PIK3CA/CREB3L2/MAP2K1/ADCY7/PLD1/PLD2	-0.813643698903962
NA	NA	hsa04519	Cadherin signaling	50/1293	404/9376	0.897444732872359	NFKBIA/AFDN/LIMA1/ACTR3/CDH1/MOB1A/APH1A/VCL/PTK2/ROCK1/ADAM10/ARPC5/EGFR/YWHAG/MAPK3/ACTR2/APC/TAOK3/NRAS/ERBB2/FAT1/TEAD1/NCSTN/YWHAE/CELSR1/IGF1R/FZD1/PKP2/MAPK1/VASP/TMC6/TAOK1/DVL3/RAC3/AMOTL2/APH1B/CYFIP1/ARHGAP35/ACTN1/ERBIN/FGFR1/CDH11/GSK3B/CTNNB1/TEAD3/LATS1/SAV1/IKBKG/MAP2K1/ACTN4	-0.842757510403033
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	23/1293	195/9376	0.855287841830765	VDAC3/SLC25A6/PLCG2/MAPK3/SLC25A5/C5AR1/CASP4/CLCN3/PIK3R1/FCGR3A/HDAC3/FCGR2A/PPIF/MAPK1/ITGB2/CYBB/AKT2/NCF1/PIK3CA/MAP3K7/MAP2K1/HDAC8/CR1	-0.816725176942755
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1293	31/9376	0.701743881446	GUSB/UGDH/ALDH7A1	-0.665241244034338
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1293	31/9376	0.701743881446	ALDH7A1/ABAT/ALDH6A1	-0.665241244034338
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1293	31/9376	0.701743881446	SRPRA/OXA1L/GET1	-0.665241244034338
NA	NA	hsa04981	Folate transport and metabolism	3/1293	31/9376	0.701743881446	FOLR2/SLCO2B1/MTHFS	-0.665241244034338
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/1293	49/9376	0.739934024653945	GALNT1/GALNT6/B4GALT3/GXYLT1/POFUT2	-0.729977038681853
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1293	22/9376	0.659213949237151	AOC1/ALDH7A1	-0.640019311893359
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1293	12/9376	0.604279453467388	CD46	-0.548589046535111
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1293	67/9376	0.757604090914338	PFKL/HK1/ADH5/LDHA/ALDH7A1/MINPP1/ACSS2	-0.796360633510514
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1293	32/9376	0.679814385150812	PFKL/GALK1/HK1	-0.725619594395144
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1293	23/9376	0.630552473183362	GOT2/GLUL	-0.709479458191783
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1293	23/9376	0.630552473183362	POMGNT1/B4GALT3	-0.709479458191783
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1293	23/9376	0.630552473183362	ATP1A1/ATP1B1	-0.709479458191783
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	35/1293	298/9376	0.851669028376856	CCL4/CCL3/CXCL8/CSH1/CCL4L2/IL1RN/TNFRSF1A/CCL3L1/TGFBR2/CXCL2/LTBR/EBI3/TNFSF10/CCL2/CSF1R/RELL1/TNFSF12/IL1B/CXCL3/GDF15/IFNGR2/CCL5/TNFRSF14/CXCR4/CSF3R/TNF/IL6ST/IL10RA/TNFRSF1B/CD4/IFNGR1/IL1R2/CXCL1/TGFBR1/CXCL16	-1.04074299300496
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/1293	115/9376	0.756662967820034	GNAI3/GNG5/DUSP1/GNAI2/MAPK3/GNG12/NRAS/ARAF/MAPK1/ALOX5/PTGS2/MAP2K1	-1.05009066141952
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/1293	149/9376	0.778668825944554	MT-ND1/GNAI3/NDUFV1/MT-ND2/MT-ND4/GNG5/NDUFA13/GNAI2/MAPK3/GNG12/MT-ND3/MAPK1/MT-ND4L/NDUFA6/PTGS2/ADCY7	-1.08919107220109
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1293	26/9376	0.557796418585282	TCN2/SCARB1	-0.903029078752051
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1293	15/9376	0.483423562773911	NFS1	-0.800788284517727
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/1293	134/9376	0.757604090914338	ROCK1/CALD1/CALM3/MAPK3/ARAF/PRKCH/PPP1R12A/MAPK1/ADM/GUCY1B1/MAP2K1/ADCY7/MYH10/MYH9	-1.13029892434533
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1293	27/9376	0.537137291971012	ELOVL5/HSD17B4	-0.963274592343371
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1293	38/9376	0.572475271705947	CD4/IKBKG/PTPRC	-1.05614783813649
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1293	28/9376	0.517953817257762	B4GALT3/B3GNT2	-1.021661253659
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1293	28/9376	0.517953817257762	CBR1/GGH	-1.021661253659
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/1293	76/9376	0.667887816990271	GNAI3/CAMK2D/GNAI2/CALM3/ATP1A1/ATP1B1/ADCY7	-1.16264931588277
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1293	17/9376	0.426550202447568	HSD17B4	-0.946463242453485
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1293	17/9376	0.426550202447568	GGT7	-0.946463242453485
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1293	17/9376	0.426550202447568	TXNRD1	-0.946463242453485
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1293	17/9376	0.426550202447568	GLUL	-0.946463242453485
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1293	69/9376	0.630552473183362	GNAI3/GNAI2/CALM3/CTSB/CREB1/GUCY1B1	-1.23188754205314
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1293	191/9376	0.759304025299336	FOSB/GNAI3/GNG5/GNAI2/CALM3/MAPK3/GNG12/NRAS/HDAC3/ARAF/CREB1/MAPK1/SHC1/SOS2/CAMKK2/SOS1/CREB3L2/MAP2K1/HDAC8/ATF2	-1.344140113119
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1293	41/9376	0.530586837190878	GAMT/SDSL/ALDH7A1	-1.20472699501329
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1293	89/9376	0.651807050931116	GNAI3/GABARAPL1/GNG5/GNAI2/GLUL/GNG12/ABAT/ADCY7	-1.32000587507759
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1293	116/9376	0.687628343600821	GNAI3/GNG5/GNAI2/MAPK3/GLUL/GNG12/MAPK1/HOMER3/ADCY7/PLD1/PLD2	-1.35392227382032
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1293	19/9376	0.381650181137298	DBT	-1.07904941811986
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1293	194/9376	0.74756221047512	KLC1/DYNC1LI1/DYNLL2/CAPZA1/ACTR1A/DCTN1/DYNC1H1/MYO15B/DNAL4/TUBA1C/HOOK3/KIFC2/DYNLRB1/TUBB/KIF1B/TUBB2A/DCTN5/KIF2A/MYH10/MYH9	-1.42097095393192
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	35/1293	323/9376	0.785750372929731	TIMP3/DICER1/CDC25B/ROCK1/ITGA5/EGFR/PLCG2/MAPK3/HNRNPK/APC/MCL1/PIK3R1/HMOX1/NRAS/ERBB2/ERBB3/BMI1/RECK/MAPK1/SHC1/PDGFB/SOS2/DDIT4/PIM1/ZEB2/RASSF1/RPS6KA5/IRS2/SOS1/PIK3CA/BRCA1/SOX4/PTGS2/MAP2K1/CD44	-1.56719734364388
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1293	103/9376	0.633613407519203	COL4A1/COL4A2/DPP4/COL1A1/ATP1A1/ATP1B1/COL3A1/SLC3A2/COL6A1	-1.49536312335745
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1293	45/9376	0.483423562773911	ABCB7/ABCA5/ABCA1	-1.38923387981135
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1293	86/9376	0.590226442921635	CAMK2D/CREB1/ATP1A1/ATP1B1/CREB3L2/ADCY7/ATF2	-1.52680618142387
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1293	36/9376	0.402852968978259	GUSB/UGDH	-1.43568016681678
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1293	36/9376	0.402852968978259	GALNT1/GALNT6	-1.43568016681678
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/1293	99/9376	0.585967954877468	CAMK2D/CALM3/PLCG2/PIK3R1/PRKCH/IL1B/PIK3CA/ADCY7	-1.65632816185827
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1293	90/9376	0.563994156569563	RXRA/ATP1A1/ATP1B1/LDLR/NCEH1/SCARB1/ADCY7	-1.66225572006735
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1293	91/9376	0.557796418585282	GNAI3/GNG5/GNAI2/GNG12/GRK6/ARRB2/ADCY7	-1.69531579768167
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/1293	183/9376	0.673622997307909	XRN1/NOP58/XPO1/GTPBP4/GNL3/DKC1/RBM28/RIOK1/UTP15/NOP56/UTP6/CSNK2A2/WDR43/LSG1/RIOK2/FCF1/DROSHA	-1.78326167397424
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1293	93/9376	0.545800796680222	CALM3/BST1/ATP1A1/LYZ/ATP1B1/GUCY1B1/ADCY7	-1.76052533177069
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1293	29/9376	0.250046670400299	CALM3	-1.61769158539094
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/1293	102/9376	0.497641902855496	RAB8A/BST1/RAP1B/RAB3D/ATP1A1/ATP1B1/ADCY7	-2.04022731676068
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/1293	86/9376	0.421590316372597	EMD/ITGA5/DAG1/PKP2/CTNNB1	-2.15514023563229
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/1293	87/9376	0.416744450667165	MT-CO3/MT-CO1/MT-CYB/ATP1A1/ATP1B1	-2.18591180584472
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/1293	99/9376	0.439475966158101	EMD/ITGA5/DAG1/PRKAA1/PRKAG2/TNF	-2.24236687374276
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1293	68/9376	0.319912651835676	ADH5/RDH11/ALDH1A2	-2.25107298425794
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/1293	254/9376	0.599521347534574	FLT1/VDAC3/CAMK2D/ITPKC/SLC25A6/EGFR/CALM3/PHKB/PLCG2/SLC25A5/ERBB2/ERBB3/PPIF/PDGFB/HGF/FGFR1/PLCD3/CXCR4/MCU/PHKA1/ADCY7	-2.58791380051297
NA	NA	hsa04382	Cornified envelope formation	17/1293	217/9376	0.56807838021819	COL4A1/PPP2R5C/SPTLC1/LAMA3/PPP2R5E/COL4A2/PRSS8/PPP2R2D/ABHD5/PKP2/S100A9/PPP2R3C/LAMA5/PPP2R5D/CLDN15/CLDN12/CLDN19	-2.57459778809495
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/1293	105/9376	0.345302544838508	EMD/ITGA5/DAG1/TNF/ADCY7	-2.69817816252616
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1293	70/9376	0.207181526903105	CBR1/PTGS2	-2.66280809188685
NA	NA	hsa04081	Hormone signaling	15/1293	219/9376	0.496668043945799	CSH1/GNAI3/GNG5/GNAI2/SMAD5/DIO2/GNG12/PIK3R1/CGA/IGF1R/STK11/THRA/IRS2/PIK3CA/ADCY7	-3.01438392946741
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/1293	79/9376	0.183578568141991	ADH5/CBR1	-2.91444013011895
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1293	66/9376	0.109868991539525	CYP11A1	-2.90234923255073
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1293	73/9376	0.0993336087891597	ADH5	-3.08967278865261
Genetic Information Processing	Translation	hsa03010	Ribosome	12/1293	222/9376	0.391965050897766	RPS18/RPS9/RPL7A/RPS25/RPS17/MRPL35/MRPS25/RPL17/RPL22L1/RPS10/RPS4Y1/MRPS17	-3.66689257529227
NA	NA	hsa04082	Neuroactive ligand signaling	6/1293	199/9376	0.218633772108804	GNAI3/GNG5/TAC3/GNAI2/GNG12/ADCY7	-4.45583827673652
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/1293	370/9376	0.195982525448883	CSH1/TAC3/C5AR1/CGA/NMB/THRA/ADM/S1PR3/LPAR6/C3AR1	-6.31101176498688
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1293	449/9376	0.0646000306602108	CAMK2D/CALM3/ARRB2/RGS2	-8.12393361121641