category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	66/1680	174/9376	2.11691297208539	MAN1A1/RRBP1/SEC24D/GANAB/TXNDC5/P4HB/CANX/RPN2/SEC61A1/XBP1/ATF6B/WFS1/CKAP4/MOGS/SEC23A/PDIA4/PRKCSH/HYOU1/SEC24A/EDEM2/UGGT1/BCAP29/ATF4/RNF5/RPN1/MAPK9/UGGT2/DDOST/SYVN1/TRAM1/MAN1A2/SKP1/EDEM3/STT3B/MAP2K7/SEL1L/DNAJC10/EDEM1/SIL1/LMAN2/PDIA3/OS9/SEC31A/LMAN1/DNAJC5/BCAP31/STT3A/TUSC3/SEC24C/SSR3/RNF185/ERP29/CUL1/MAN1B1/UBQLN2/MBTPS1/UBQLN4/BAK1/UBXN6/SSR2/DERL3/PREB/MAN1C1/PDIA6/UBE2D4/TRAF2	6.94801254934361
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	28/1680	56/9376	2.79047619047619	MAN1A1/MGAT5/MGAT4B/MGAT4A/GANAB/MAN2A1/RPN2/MOGS/RPN1/DHRSX/MGAT1/DDOST/MAN1A2/STT3B/MGAT5B/STT3A/TUSC3/B4GALT2/FUT8/MAN1B1/B4GALT3/MGAT3/DPAGT1/ALG9/ALG1/DPM2/MAN1C1/DOLK	6.27859336951396
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	53/1680	144/9376	2.05410052910053	FGFR1/PIK3CB/DLX5/DUSP9/AXIN2/PIK3R2/MAPK3/JARID2/AKT3/ID1/BMPR2/IL6ST/SMAD3/ID3/LIFR/KAT6A/JAK1/INHBA/PCGF2/GRB2/TBX3/RAF1/HRAS/FZD8/PCGF3/AKT1/SMAD4/RIF1/KLF4/BMI1/ZFHX3/TCF7/WNT7A/DVL3/ESX1/NRAS/FZD5/BMPR1B/PIK3R3/ACVR1/AKT2/TCF3/AXIN1/MAPK14/FZD9/FZD10/OTX1/ISL1/JAK2/SETDB1/FZD2/ACVR2B/FGFR3	5.95556719476452
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	79/1680	250/9376	1.76358095238095	GAA/LGMN/CTSB/GM2A/AP2A2/NAGLU/CLN3/PSAP/IGF2R/HEXB/SLC15A3/GLB1/CTSV/CLTB/SLC36A1/HEXA/CD68/MAN2B1/SNAP29/ENTPD4/AP3S1/AGA/OSTM1/SCARB2/CD63/PLEKHM1/ARSA/LAMP2/CLN5/SLC38A9/HGSNAT/AP3D1/AP3B1/GGA1/HYAL4/CTSA/AP5B1/OSBPL2/SLC36A4/MITF/CTSL/DMXL1/NAGA/CLTC/CTSO/CLCN7/GUSB/ARSB/CD164/SLC29A2/VPS39/VAMP7/SLC29A1/AP1B1/LAMP1/GGA3/PIKFYVE/SLC11A2/CTSZ/ATP6V0A1/DEPTOR/AP4E1/CLN6/SLC29A3/PPT2/ROGDI/LAPTM4A/TPCN1/VPS18/SPG11/MTOR/BORCS6/PLA2G15/GALNS/AP1G2/ATP6V1C2/TLR7/ZFYVE26/ATP6V1E2	5.71732141540548
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	38/1680	98/9376	2.16404275996113	DGKZ/IMPA2/PIK3CB/INPPL1/ITPR2/INPP5B/PLCG2/PIK3R2/IPMK/SYNJ2/PI4KA/MTMR4/PIP4K2B/MTMR1/CALM3/PIK3C2A/IPPK/PIKFYVE/PIK3C2B/PIK3R3/INPP4A/PIP4P2/DGKH/PIK3C3/PLCB1/PLCD3/SYNJ1/PLCG1/MTMR3/INPP5A/CDS2/PI4K2A/PIP4K2C/DGKQ/PLCB3/CALML4/OCRL/INPP5E	5.41205918494032
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	43/1680	122/9376	1.96705698672912	DIO2/PIK3CB/PLCG2/PIK3R2/MAPK3/MED13L/TBC1D4/AKT3/FOXO1/RXRB/EP300/SLC9A1/RXRA/SLC16A2/MED17/NCOA3/ATP1A1/PFKL/RAF1/HRAS/AKT1/NCOA1/RCAN1/NOTCH3/THRB/MED16/HDAC1/NRAS/MED1/PIK3R3/SLC2A1/NCOR1/AKT2/NCOA2/KAT2A/PLCB1/PLCD3/TP53/PLCG1/MTOR/MED24/MED12/PLCB3	5.02313654966354
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	68/1680	227/9376	1.6718271449549	HLA-G/PIK3CB/IL10RB/CCL3/ITPR2/TAPBP/IL10RA/PXN/TAP1/PIK3R2/MAPK3/RAC3/TAP2/IL1R1/IRF3/CREB3L2/PTK2B/CREB5/CCR1/GNG12/CCL4/ATF6B/CCL4L2/AKT3/BCAR1/ATF4/PTGER3/CRKL/GNAI1/ADCY7/TAPBPL/JAK1/GRB2/NFATC4/RAF1/HRAS/AKT1/RB1/TSC1/PTK2/GNA12/PDIA3/SP1/GNAS/ROCK2/ADCY5/CALM3/TBK1/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/EIF4EBP1/E2F3/PLCB1/MAPK14/TP53/ADCY9/RIPK1/GNA11/MTOR/PLCB3/CALML4/FADD/TRAF2/TRADD	4.78730846564114
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	21/1680	44/9376	2.66363636363636	MAN1A1/MGAT4B/MGAT4A/MAN2A1/RPN2/HEXB/HEXA/RPN1/MGAT1/DDOST/MAN1A2/STT3B/STT3A/TUSC3/B4GALT2/FUT8/MAN1B1/B4GALT3/ALG9/ALG1/MAN1C1	5.16779321386456
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	19/1680	38/9376	2.79047619047619	GFPT1/UGDH/HEXB/GNE/HEXA/PGM3/UGP2/GALK1/GALE/GMPPA/PMM2/UXS1/GALT/HK1/RENBP/GNPDA1/PGM1/GFPT2/GALK2	5.16703214354359
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	30/1680	78/9376	2.14652014652015	IMPA2/PIK3CB/INPPL1/INPP5B/PLCG2/IPMK/SYNJ2/PI4KA/ISYNA1/MTMR4/PIP4K2B/MTMR1/PIK3C2A/IPPK/PIKFYVE/PIK3C2B/INPP4A/PIK3C3/PLCB1/PLCD3/SYNJ1/MINPP1/PLCG1/MTMR3/INPP5A/PI4K2A/PIP4K2C/PLCB3/OCRL/INPP5E	4.75052896557439
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	72/1680	253/9376	1.58825522303783	ITGA5/PIK3CB/CTTN/ITPR2/ACTN4/TECPR1/PLCG2/PXN/PIK3R2/MAPK3/ARPC1B/IL1R1/IRF3/SEPTIN3/ARHGEF2/AKT3/BCAR1/FOXO1/WIPI1/ITGB1/CYTH3/TLN1/CD14/RNF31/MAPK9/CRKL/ELMO1/ACTN1/CYTH1/SKP1/AKT1/PTK2/ATM/FNBP1L/CBX3/ATG16L1/FOXO4/ROCK2/PRKCE/RBCK1/SEPTIN9/MAP3K7/HK1/TBK1/ACTR3B/PIK3R3/ILK/EGFR/ARPC2/CUL1/AKT2/TLN2/RPS6KA5/WIPI2/GSK3A/PIK3C3/PLCB1/PLCD3/MAPK14/TP53/CYTH2/RIPK1/PLCG1/MTOR/PLCB3/DOCK1/TAB1/ELMO2/SEPTIN8/UBE2D4/TRAF2/TRADD	4.43164500977435
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	45/1680	138/9376	1.81987577639752	PTPRF/PIK3CB/FASN/INPPL1/PRKAG2/PIK3R2/MAPK3/CBL/RAPGEF1/AKT3/CBLB/SREBF1/FLOT1/FOXO1/INSR/PPP1R3B/FLOT2/SH2B2/PHKA2/MAPK9/CRKL/PRKAG1/GRB2/RAF1/HRAS/AKT1/TSC1/GYS1/PPP1R3D/CALM3/PRKCI/HK1/SOS1/MKNK1/NRAS/PIK3R3/PHKB/ACACA/AKT2/EIF4EBP1/INPP5A/MTOR/CALML4/PYGB/PRKAB2	4.53321554098661
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	41/1680	122/9376	1.87556596409055	PIK3CB/ITPR2/PLCG2/PIK3R2/MAPK3/CREB3L2/CREB5/ATF6B/AKT3/BCAR1/IGFBP3/ATF4/FOS/EP300/MAPK9/CRKL/GNAI1/ADCY7/GRB2/RAF1/HRAS/AKT1/PTK2/GNAS/ADCY5/SOS1/NRAS/PIK3R3/CSH1/AKT2/PLCB1/SST/MAPK14/ADCY9/PLCG1/GNA11/SSTR2/CACNA1C/MTOR/PLCB3/JAK2	4.54790922998275
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	54/1680	178/9376	1.69309791332263	NOTUM/SFRP1/TCF7L2/TLE3/BAMBI/AXIN2/RAC3/CSNK2B/ANKRD6/CTNND2/TLE6/CSNK1E/CAMK2G/SMAD3/CTBP2/EP300/MAPK9/TLE1/GPC4/SKP1/NFATC4/TCF7L1/FZD8/SMAD4/APCDD1/CSNK1A1/PPARD/ROCK2/FRAT2/SIAH1/MAP3K7/TCF7/WNT7A/DVL3/TBL1Y/FRAT1/FZD5/DAAM2/TLE2/CUL1/AXIN1/CSNK2A2/PLCB1/RYK/TP53/FZD9/CCAR2/FZD10/FRZB/LRP6/PLCB3/LZTS2/CELSR2/FZD2	4.3617989079518
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	60/1680	204/9376	1.64145658263305	FGFR1/ITGA5/FN1/TIMP3/HSPG2/TGFB2/PIK3CB/CTTN/ITPR2/VAV3/PLCG2/PXN/PIK3R2/MAPK3/ERBB2/ERBB3/CBL/AKT3/CAMK2G/TGFB1/VAV2/ITGB1/PPP1R12C/CD63/SLC9A1/GRB2/PAK1/RAF1/HRAS/FZD8/AKT1/PPP1R12B/SDC4/PTK2/TIAM1/MRAS/CTSL/ROCK2/MMP2/GPC3/GPC1/WNT7A/SOS1/RDX/NRAS/FZD5/PIK3R3/EGFR/IQGAP1/AKT2/PTCH1/FRS2/MAPK14/TP53/FZD9/DROSHA/PLCG1/FZD10/MTOR/FZD2	4.32770925736103
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/1680	59/9376	2.27021791767555	TCF7L2/PIK3CB/AXIN2/PIK3R2/MAPK3/ERBB2/AKT3/GRB2/TCF7L1/RAF1/HRAS/AKT1/TCF7/SOS1/NRAS/PIK3R3/ILK/EGFR/AKT2/AXIN1/BAK1/TP53/CDH1/CTNNA3	4.57271297765996
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	27/1680	70/9376	2.15265306122449	EPAS1/TGFB2/PIK3CB/PIK3R2/MAPK3/RAPGEF1/AKT3/EGLN3/TGFB1/ARNT2/PDGFB/EP300/EGLN2/CRKL/ARNT/GRB2/PAK1/RAF1/HRAS/AKT1/PAK2/EGLN1/SOS1/NRAS/PIK3R3/SLC2A1/AKT2	4.52245082737183
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/1680	29/9376	2.88669950738916	LIMD1/TEAD1/CSNK1E/TEAD3/PAK1/RASSF6/WWTR1/RASSF4/SAV1/LATS1/MOB1B/FRMD6/AJUBA/STK3/WTIP	4.75415528742028
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	88/1680	333/9376	1.47484627484627	SPP1/ITGA5/COL4A1/COL4A2/FN1/CCNE1/HLA-G/TCF7L2/PIK3CB/IFNAR2/HES2/AXIN2/PXN/PIK3R2/MAPK3/IRF3/CREB3L2/CREB5/AKT3/FOXO1/LAMA5/STAT2/PARD6G/HEY1/ITGB1/LAMB1/PPP2R3B/EP300/PARD3/LAMA4/MAML2/JAK1/ISG15/GRB2/MAML1/TCF7L1/RAF1/HRAS/FZD8/AKT1/RB1/TSC1/SCRIB/PTK2/IFNAR1/ATM/PPP2R5E/CHD4/LAMC1/GNAS/NOTCH3/CSNK1A1/DLG1/BCAP31/TYK2/LLGL2/PRKCI/TCF7/WNT7A/TBK1/DVL3/RBL2/SOS1/HDAC1/NRAS/FZD5/TRAF3/PIK3R3/EGFR/ATP6V0A1/MAML3/AKT2/ITGA3/AXIN1/BAK1/EIF4EBP1/TP53/FZD9/FZD10/MTOR/FADD/TBP/ATP6V1C2/ATR/NFX1/FZD2/TRADD/ATP6V1E2	4.1221770039919
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	61/1680	212/9376	1.60584007187781	FGFR1/FLT1/PGF/CSF1R/PIK3CB/EFNA1/VAV3/APBB1IP/PIK3R2/MAPK3/RAC3/VASP/RAPGEF1/EVL/PRKD3/AKT3/BCAR1/ID1/VAV2/PARD6G/INSR/PDGFB/ITGB1/TLN1/CTNND1/FLT4/PARD3/CRKL/GNAI1/ADCY7/RAF1/HRAS/AKT1/TIAM1/MRAS/LPAR2/GNAS/RAPGEF2/FGF18/ADCY5/CALM3/PRKCI/NRAS/RAPGEF3/PIK3R3/EGFR/AKT2/TLN2/TEK/EFNA4/PLCB1/MAPK14/ADCY9/PLCG1/PLCB3/CALML4/P2RY1/CDH1/RAP1GAP/FGFR3/ANGPT2	4.16860874337278
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	13/1680	24/9376	3.02301587301587	EXTL3/HS6ST1/NDST1/B4GALT7/EXT2/XYLT1/HS3ST1/GLCE/NDST2/XYLT2/B3GALT6/EXTL1/B3GAT3	4.6361813082161
NA	NA	hsa04517	IgSF CAM signaling	80/1680	299/9376	1.49323140627488	FGFR1/ITGA5/PTPRF/IL1RAP/ESAM/TUBB2A/PIK3CB/TJP2/F11R/TUBB/CABLES1/ACTN4/VAV3/PLCG2/PXN/PIK3R2/MAPK3/ARPC1B/PVR/MPDZ/RASA1/JAM2/MYH10/TJP1/AKT3/LYN/MYH9/BCAR1/NECTIN4/FOXO1/VAV2/PARD6G/TRIO/PMP22/ITGB1/SRGAP2/MTSS2/MAPK9/PARD3/ERC1/TUBA1C/ACTN1/PPFIA1/GRB2/PAK1/GRIP1/AKT1/EPB41L3/PAK2/PTK2/SRGAP1/DYNLL2/GIT1/TUBB6/NRP1/RAPGEF2/NLGN2/MAG/PRKCI/ROBO3/PLXNA3/RDX/ACTR3B/PIK3R3/SLIT3/IQGAP1/PTPRS/ARPC2/AKT2/MTSS1/L1CAM/MAPK14/CD84/DOK1/PLCG1/NTN1/MPP3/CD209/GLDN/CDH1	4.04970043103209
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	17/1680	37/9376	2.56422136422136	GFPT1/UGDH/GNE/PGM3/UGP2/GALK1/GALE/GMPPA/PMM2/UXS1/GALT/HK1/PGM1/NANS/GFPT2/GALK2/TGDS	4.45406588722155
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/1680	184/9376	1.63788819875776	SEMA4C/SEMA7A/PIK3CB/EPHB2/EFNA1/EFNB1/PLCG2/PIK3R2/MAPK3/RAC3/EPHB3/RASA1/NTN4/SEMA4B/SSH2/CAMK2G/BMPR2/PARD6G/ITGB1/PLXNB2/SRGAP2/PARD3/GNAI1/BOC/PAK1/NFATC4/RAF1/HRAS/PAK2/PTK2/SEMA4A/SRGAP1/LIMK2/NRP1/ROCK2/SEMA5A/ROBO3/PLXNA3/NRAS/BMPR1B/PIK3R3/SLIT3/ILK/EFNA4/PTCH1/L1CAM/RYK/SSH3/EFNB2/PLCG1/LRRC4/NTN1/SEMA4G/LRIG2	4.08278227614732
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	24/1680	62/9376	2.16036866359447	TLE3/NCSTN/TLE6/DTX4/NCOR2/HEY1/ITCH/CTBP2/EP300/TLE1/SPEN/MAML2/MAML1/DTX3L/NOTCH3/DTX2/DVL3/HDAC1/MAML3/TLE2/KAT2A/PSEN2/ATXN1L/PTCRA	4.28283624533722
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	49/1680	163/9376	1.67770961145194	HSPG2/CCNE1/DDB1/TGFB2/PIK3CB/PIK3R2/MAPK3/IRF3/CREB3L2/PTK2B/CREB5/ATF6B/AKT3/TGFB1/STAT2/SMAD3/ATF4/FOS/EP300/MAPK9/EGR3/JAK1/GRB2/TICAM2/NFATC4/RAF1/HRAS/MAP2K7/AKT1/RB1/APAF1/IFNAR1/SMAD4/STAT6/TYK2/MAP3K7/TBK1/SOS1/NRAS/TRAF3/PIK3R3/MAVS/AKT2/E2F3/MAPK14/TP53/FADD/JAK2/TAB1	4.07797595887202
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	28/1680	78/9376	2.0034188034188	ITGA5/FN1/PIK3CB/CTTN/DNM2/PXN/PIK3R2/ARPC1B/SEPTIN3/CBL/BCAR1/CLTB/ITGB1/ARHGAP10/CRKL/ELMO1/PTK2/CLTC/SEPTIN9/ACTR3B/PIK3R3/ILK/ARPC2/DOCK1/ELMO2/SEPTIN8/CDH1/CTNNA3	4.15759819372634
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	31/1680	90/9376	1.92232804232804	PPARG/PIK3CB/PRKAG2/PIK3R2/SESN2/CREB3L2/CREB5/ATF6B/AKT3/FOXO1/INSR/EHMT2/ATF4/PRKAG1/ADCY7/HRAS/AKT1/TSC1/ATG13/STK11/ADCY5/NRAS/PIK3R3/AKT2/CAMKK2/EIF4EBP1/TP53/ADCY9/MTOR/ULK1/PRKAB2	4.10771286014059
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	45/1680	148/9376	1.6969111969112	FGFR1/TCF7L2/PIK3CB/AXIN2/PIK3R2/MAPK3/ERBB2/AKT3/HEY1/FOS/FLT4/NCOA3/GRB2/TCF7L1/RAF1/HRAS/FZD8/AKT1/RB1/NCOA1/BRCA2/SP1/NOTCH3/CSNK1A1/FRAT2/FGF18/TCF7/WNT7A/DVL3/SOS1/FRAT1/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/FZD10/LRP6/MTOR/FZD2	3.99265933445912
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/1680	157/9376	1.67073096754625	PPARG/LRP1/ABCA1/SLC16A1/CEBPB/STAB1/MAPK3/C1QA/ATP11A/CAMK2G/TGFB1/BCAR1/DUSP4/C1QB/ADAM10/EPOR/CRKL/ARNT/RXRA/ELMO1/SGK1/ADAM9/NFATC4/CASP7/PTK2/CPT1B/TGFBRAP1/PPARD/STAB2/DUSP16/CPT1A/VPS39/BSG/RAB5C/SLC2A1/ANO6/MAPK14/ANO4/VPS8/VPS18/AGER/ANO9/PLA2G15/DOCK1/JAK2/CH25H/P2RY6	3.9597158900535
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	79/1680	300/9376	1.46965079365079	FGFR1/FLT1/PGF/IL1RAP/CSF1R/RASGRF2/TGFB2/EFNA1/DUSP9/MAPK3/MAPK8IP3/RAC3/IL1R1/CACNA1A/RASA1/ERBB2/ERBB3/GNG12/AKT3/TGFB1/INSR/PDGFB/DUSP4/CD14/ATF4/FOS/FLT4/MAPK9/DAXX/CRKL/MAP3K10/GRB2/PAK1/RAF1/HRAS/MAP2K7/AKT1/SRF/RPS6KA1/PAK2/GNA12/MRAS/TAOK3/TAOK1/DUSP1/RASGRF1/NF1/RAPGEF2/DUSP16/FGF18/MAP3K7/SOS1/MKNK1/NRAS/MAP3K14/EGFR/PTPRR/AKT2/TEK/RPS6KA5/TAOK2/MAP4K3/EFNA4/MAPK14/TP53/MAP4K2/MAP3K9/CACNA1C/MAPT/CACNB3/MAP3K4/PPP5C/PLA2G4B/TAB1/STK3/TRAF2/TRADD/FGFR3/ANGPT2	3.8627463771637
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	68/1680	250/9376	1.51801904761905	ASAP3/IQSEC1/HLA-G/GRK3/DNM2/ARFGAP1/ARPC1B/VPS28/AP2A2/IL2RB/SH3GL1/IGF2R/CBL/EHD3/CBLB/SH3GL3/CLTB/PARD6G/ITCH/SMAD3/CYTH3/FOLR2/SNX5/PARD3/TFRC/CYTH1/ARF4/FOLR1/GBF1/ARAP1/HRAS/EPN2/HGS/ARFGEF1/WASHC1/GIT1/CLTC/SMURF1/VPS36/WIPF2/GRK5/ARFGEF2/EPN1/ZFYVE9/PRKCI/DAB2/ACTR3B/RAB5C/WASHC4/ACAP3/EGFR/ARPC2/CHMP1A/SNX4/AGAP5/MVB12B/GRK4/CYTH2/PLD2/STAM2/WASHC5/ZFYVE27/VPS25/AGAP9/AGAP4/MVB12A/FGFR3/VPS45	3.87867374808839
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	33/1680	99/9376	1.86031746031746	PIK3CB/PIK3R2/MAPK3/ERBB2/AKT3/CARM1/FOS/MAPK9/ADCY7/NCOA3/GRB2/RAF1/HRAS/AKT1/RB1/PTK2/SP1/GNAS/NOTCH3/ADCY5/MMP2/SOS1/NRAS/MED1/PIK3R3/EGFR/NCOR1/AKT2/E2F3/MAPK14/TP53/ADCY9/MTOR	4.02050221422604
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	45/1680	150/9376	1.67428571428571	CCNE1/TCF7L2/TGFB2/PIK3CB/AXIN2/PIK3R2/MAPK3/ERBB2/AKT3/TGFB1/SMAD3/RXRB/RXRA/GRB2/TCF7L1/RAF1/HRAS/FZD8/AKT1/RB1/SMAD4/CSNK1A1/FRAT2/FGF18/TCF7/WNT7A/DVL3/SOS1/FRAT1/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/FZD10/LRP6/MTOR/CDH1/FZD2/CTNNA3	3.88947167019827
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	35/1680	109/9376	1.79204892966361	PTPRF/PIK3CB/GFPT1/PRKAG2/PIK3R2/CREB3L2/CREB5/SLC27A1/TBC1D4/AKT3/SREBF1/FOXO1/INSR/MLXIP/PPP1R3B/MAPK9/PRKAG1/AKT1/RPS6KA1/GYS1/CPT1B/OGA/PRKCE/PPP1R3D/CPT1A/SLC27A3/PIK3R3/SLC2A1/PPARA/AKT2/GFPT2/PTPA/MTOR/PYGB/PRKAB2	3.88600565651798
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	31/1680	93/9376	1.86031746031746	FGFR1/PTPRF/TCF7L2/ACTN4/SNAI1/MAPK3/RAC3/CSNK2B/ERBB2/TJP1/NECTIN4/INSR/SMAD3/CTNND1/EP300/PARD3/ACTN1/TCF7L1/SMAD4/ROCK2/SMURF1/MAP3K7/TCF7/CCM2/EGFR/IQGAP1/CSNK2A2/PTPRB/FER/CDH1/CTNNA3	3.89550517551464
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	31/1680	93/9376	1.86031746031746	COL4A1/COL4A2/FN1/CCNE1/BIRC7/PIK3CB/PIK3R2/AKT3/LAMA5/ITGB1/RXRB/LAMB1/LAMA4/RXRA/AKT1/RB1/APAF1/PTK2/XIAP/LAMC1/TRAF3/CKS1B/PIK3R3/AKT2/ITGA3/NOS2/BAK1/E2F3/TP53/ZBTB17/TRAF2	3.89550517551464
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	63/1680	232/9376	1.51551724137931	FGFR1/ITGA5/FN1/PIK3CB/ACTN4/VAV3/PXN/PIK3R2/MAPK3/ARPC1B/RAC3/MYH10/GNG12/CHRM5/AKT3/SSH2/MYH9/BCAR1/VAV2/PDGFB/ITGB1/PPP1R12C/ARHGEF7/CRKL/CYFIP1/SLC9A1/ACTN1/CYFIP2/PAK1/RAF1/HRAS/AKT1/PPP1R12B/PAK2/PTK2/TIAM1/GNA12/MRAS/PIP4K2B/GIT1/NCKAP1/LIMK2/LPAR2/ROCK2/FGF18/SOS1/RDX/NRAS/ACTR3B/PIKFYVE/PIK3R3/EGFR/IQGAP1/ARPC2/AKT2/ITGA3/ARHGEF4/SSH3/DIAPH2/PIP4K2C/DOCK1/C9/FGFR3	3.71472636400105
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1680	106/9376	1.79011680143756	FGFR1/CCNE1/TCF7L2/PIK3CB/PIK3R2/MAPK3/CREB3L2/CREB5/ERBB2/AKT3/FOXO1/PDGFB/FOLR2/ATF4/EP300/FOLR1/GRB2/ETV5/TCF7L1/RAF1/HRAS/AKT1/RB1/IL1R2/TCF7/SOS1/NKX3-1/NRAS/PIK3R3/EGFR/AKT2/E2F3/TP53/MTOR	3.82218859311861
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	49/1680	170/9376	1.60862745098039	TCF7L2/TGFB2/SMARCB1/PIK3CB/HMOX1/PLCG2/AXIN2/PIK3R2/MAPK3/AKT3/TGFB1/GSTA3/SMAD3/SMARCA4/GRB2/TCF7L1/RAF1/HRAS/FZD8/PBRM1/AKT1/RB1/SMAD4/SMARCD2/CSNK1A1/SMARCC1/FRAT2/SMARCC2/TCF7/WNT7A/DVL3/SOS1/FRAT1/NRAS/FZD5/PIK3R3/EGFR/AKT2/AXIN1/BAK1/E2F3/TP53/FZD9/PLCG1/FZD10/LRP6/MTOR/FZD2/GSTT1	3.74152164027802
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	32/1680	98/9376	1.822351797862	ASAP3/PIK3CB/INPPL1/DNM2/VAV3/PLCG2/PIK3R2/MAPK3/ARPC1B/VASP/MYO10/AKT3/LYN/VAV2/CRKL/PLPP2/PAK1/RAF1/AKT1/LIMK2/PRKCE/ACTR3B/FCGR3A/PIK3R3/ARPC2/AKT2/GAB2/PLCG1/FCGR2B/PLD2/DOCK1/PLA2G4B	3.82341332634538
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	44/1680	149/9376	1.64806647491211	DGKZ/PIK3CB/DNM2/PLCG2/PIK3R2/MAPK3/PTK2B/AGTR1/AKT3/INSR/PDGFB/AGPAT1/CYTH3/ADCY7/CYTH1/PLPP2/GRB2/RAF1/HRAS/AKT1/TSC1/GNA12/MRAS/LPAR2/GNAS/ADCY5/SOS1/NRAS/RAPGEF3/PIK3R3/LPAR6/EGFR/AKT2/GAB2/DGKH/PLCB1/ADCY9/CYTH2/PLCG1/PLD2/MTOR/DGKQ/PLCB3/PLA2G4B	3.72554813550925
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	23/1680	63/9376	2.03749055177627	PLOD2/PLOD3/PIPOX/KMT2C/PLOD1/EHMT2/COLGALT1/PRDM2/DOT1L/NSD3/NSD1/ASH1L/KMT2D/SUV39H1/KMT5C/SETD1B/ALDH1B1/SETD1A/KMT2B/AADAT/SUV39H2/ALDH3A2/SETDB1	3.86026725736675
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	11/1680	21/9376	2.92335600907029	CHPF/DSEL/B4GALT7/XYLT1/CHST11/CHPF2/CHST14/CSGALNACT1/XYLT2/B3GALT6/B3GAT3	4.12244793766719
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	32/1680	99/9376	1.8039442039442	DGKZ/PIK3CB/PIK3R2/MAPK3/RAC3/AKT3/CHKB/PDGFB/FOS/MAPK9/PLPP2/LYPLA1/GRB2/RAF1/HRAS/AKT1/TSC1/SP1/SOS1/NRAS/PIK3R3/EGFR/AKT2/SLC44A5/DGKH/EIF4EBP1/PLCG1/PLD2/MTOR/DGKQ/PLA2G4B/SLC22A4	3.75705434465918
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	25/1680	71/9376	1.96512407780013	FGFR1/SLC16A3/PIK3CB/IDH2/PIK3R2/MAPK3/ERBB2/LDHA/AKT3/PFKL/RAF1/HRAS/AKT1/HK1/NRAS/IDH1/PIK3R3/SLC2A1/EGFR/AKT2/TIGAR/TP53/MTOR/PDK1/FGFR3	3.81383487404972
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	41/1680	137/9376	1.67021202641641	CSF2RB/CTSB/DAB2IP/PIK3CB/ITPR2/TNFSF10/PIK3R2/MAPK3/AKT3/CTSV/ENDOG/ATF4/FOS/MAPK9/DAXX/TUBA1C/DFFB/PTPN13/RAF1/HRAS/AKT1/APAF1/CASP7/ATM/CASP2/XIAP/CTSL/CTSO/NRAS/MAP3K14/CTSZ/PIK3R3/AKT2/BAK1/TP53/RIPK1/FADD/LMNB2/TRAF2/TRADD/PIDD1	3.69205163505599
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	48/1680	169/9376	1.58512256973795	CTSB/PIK3CB/PIK3R2/MAPK3/AKT3/WIPI1/SNAP29/EIF2AK4/MAPK9/PLEKHM1/ATG9A/LAMP2/GORASP2/DAPK3/RAF1/HRAS/AKT1/MTMR4/TSC1/MRAS/ATG13/SMCR8/CTSL/ATG16L1/STK11/RAB1A/YKT6/BIRC6/VPS39/MAP3K7/TBK1/LAMP1/NRAS/ATG16L2/PIK3R3/DEPTOR/ATG2B/AKT2/GORASP1/CAMKK2/WIPI2/EPG5/PIK3C3/ULK2/MTMR3/VPS18/MTOR/ULK1	3.58623612185698
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	48/1680	170/9376	1.57579831932773	CLDN19/CLDN7/TJP2/CTTN/F11R/PRKAG2/ACTN4/ARPC1B/SYMPK/MPDZ/JAM2/MYH10/VASP/ERBB2/TJP1/AMOTL2/ARHGEF2/MYH9/CGNL1/PARD6G/ITGB1/MAPK9/PARD3/TUBA1C/PRKAG1/ACTN1/RAB8B/MAP2K7/SCRIB/TIAM1/MICALL2/SYNPO/STK11/RAPGEF2/ROCK2/PRKCE/DLG1/LLGL2/PRKCI/RDX/ACTR3B/TJAP1/ARPC2/MARVELD2/ARHGEF18/CLDN23/CLDN14/PRKAB2	3.53970539569012
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/1680	93/9376	1.80030721966206	MMP14/ITPR2/MAPK3/PTK2B/CGA/CAMK2G/ATF4/MAPK9/ADCY7/GRB2/RAF1/HRAS/MAP2K7/GNAS/ADCY5/CALM3/MMP2/SOS1/NRAS/EGFR/PLCB1/MAPK14/ADCY9/GNA11/CACNA1C/PLD2/MAP3K4/PLCB3/CALML4/PLA2G4B	3.62377966273622
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	26/1680	77/9376	1.88447742733457	TGFB2/PIK3CB/PIK3R2/MAPK3/CBL/AKT3/TGFB1/SMAD3/CTBP2/CRKL/GRB2/RAF1/HRAS/AKT1/RB1/SMAD4/BCR/SOS1/HDAC1/NRAS/PIK3R3/AKT2/GAB2/BAK1/E2F3/TP53	3.64100891309452
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	34/1680	110/9376	1.72502164502164	FLT1/EPAS1/PIK3CB/HMOX1/PLCG2/PIK3R2/MAPK3/ERBB2/LDHA/AKT3/CAMK2G/EGLN3/INSR/SERPINE1/EP300/EGLN2/TFRC/ARNT/PFKL/AKT1/EGLN1/HK1/MKNK1/PIK3R3/SLC2A1/EGFR/AKT2/TEK/NOS2/EIF4EBP1/PLCG1/MTOR/PDK1/ANGPT2	3.57362449684921
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	28/1680	86/9376	1.81705426356589	PIK3CB/PLCG2/PIK3R2/MAPK3/ERBB2/ERBB3/CBL/AKT3/CAMK2G/CBLB/MAPK9/CRKL/GRB2/PAK1/RAF1/HRAS/MAP2K7/AKT1/PAK2/PTK2/SOS1/NRAS/PIK3R3/EGFR/AKT2/EIF4EBP1/PLCG1/MTOR	3.55631333922966
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	28/1680	87/9376	1.79616858237548	TCF7L2/TGFB2/PIK3CB/AXIN2/PIK3R2/MAPK3/RAC3/AKT3/TGFB1/SMAD3/FOS/MAPK9/GRB2/TCF7L1/RAF1/HRAS/AKT1/SMAD4/TCF7/SOS1/NRAS/PIK3R3/EGFR/AKT2/AXIN1/BAK1/TP53/MTOR	3.48568333681259
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	27/1680	83/9376	1.81549053356282	CSNK2B/BCORL1/JARID2/MGA/EP300/RING1/SKP1/PCGF2/L3MBTL3/PHC2/HCFC1/PCGF3/L3MBTL1/CBX3/BCOR/BMI1/DCAF7/SFMBT1/HDAC1/FOXK2/PHC1/EED/ASXL2/BAP1/CBX8/RBBP7/UBE2D4	3.48648459932209
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	44/1680	157/9376	1.56408856536245	TCF7L2/TGFB2/LIMD1/AXIN2/TEAD1/DLG5/CSNK1E/TGFB1/ID1/BMPR2/PARD6G/YWHAE/SMAD3/SERPINE1/PARD3/TEAD3/TCF7L1/FZD8/SCRIB/SMAD4/RASSF6/DLG1/WWTR1/LLGL2/PRKCI/TCF7/WNT7A/DVL3/SAV1/LATS1/MOB1B/FZD5/BMPR1B/AMH/AXIN1/FZD9/FZD10/FRMD6/AJUBA/STK3/CDH1/FZD2/CTNNA3/WTIP	3.33014362499842
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	36/1680	122/9376	1.64683840749415	PPARG/PIK3CB/FASN/PRKAG2/PIK3R2/CREB3L2/CREB5/AKT3/SREBF1/FOXO1/INSR/PPP2R3B/PRKAG1/PFKFB4/EEF2K/PFKL/EEF2/AKT1/TSC1/GYS1/CPT1B/PPP2R5E/STK11/CPT1A/MAP3K7/PIK3R3/TBC1D1/ACACA/AKT2/CAMKK2/MLYCD/EIF4EBP1/STRADA/MTOR/ULK1/PRKAB2	3.35984093078077
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	25/1680	77/9376	1.81199752628324	TGFB2/PIK3CB/PIK3R2/MAPK3/RAC3/ERBB2/AKT3/TGFB1/SMAD3/RALBP1/MAPK9/JAK1/RAF1/AKT1/RB1/BRCA2/SMAD4/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLD2/MTOR	3.34264068164809
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1680	69/9376	1.86031746031746	PIK3CB/VAV3/PLCG2/PIK3R2/MAPK3/RAC3/AKT3/LYN/VAV2/MAPK9/GRB2/RAF1/HRAS/MAP2K7/AKT1/SOS1/NRAS/PIK3R3/AKT2/GAB2/MAPK14/PLCG1/PLA2G4B	3.35109064225685
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	22/1680	65/9376	1.88893772893773	SPP1/PIK3CB/ITPR2/PIK3R2/MAPK3/CGA/AKT3/RAF1/HRAS/AKT1/KISS1R/NRAS/PIK3R3/AKT2/KCNN2/PLCB1/GNA11/CACNA1C/KCNJ6/KCNJ5/PLCB3/HCN3	3.35998705180384
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	38/1680	133/9376	1.59455782312925	TGFB2/PIK3CB/FBXO32/PRKAG2/TNFSF10/PIK3R2/MAPK3/PLK2/CCNG2/CSNK1E/AKT3/TGFB1/FOXO1/HOMER1/INSR/SMAD3/DEPP1/EP300/MAPK9/PRKAG1/SGK1/GRB2/RAF1/HRAS/AKT1/SMAD4/ATM/FOXO4/STK11/PLK3/RBL2/SOS1/NRAS/PIK3R3/EGFR/AKT2/MAPK14/PRKAB2	3.22642215650504
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	40/1680	142/9376	1.57209926224011	DDB1/BIRC7/HERC1/UBE2K/CBL/CBLB/ITCH/HERC2/UBE2H/PPIL2/TRIP12/UBE2Q2/SYVN1/UBE2A/CDC34/SKP1/HERC3/UBE2Z/XIAP/UBR5/SMURF1/SIAH1/BIRC6/CUL4B/MGRN1/UBE2L6/UBE2O/HERC4/PRPF19/WWP2/CUL1/FBXW8/TRIM37/KLHL9/UBE3C/UBA7/DET1/SAE1/UBE3B/UBE2D4	3.2094334474376
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	39/1680	138/9376	1.57722567287785	ITGA5/FN1/PIK3CB/VAV3/PXN/PIK3R2/MAPK3/ARPC1B/RAC3/IRF3/PTK2B/AKT3/PKN1/BCAR1/VAV2/ITGB1/FOS/MAPK9/ARHGEF7/CRKL/ELMO1/MAP2K7/AKT1/RPS6KA1/PTK2/ROCK2/WIPF2/MAP3K7/TBK1/ACTR3B/PIK3R3/ARPC2/AKT2/MAPK14/PLCG1/DOCK1/TAB1/ELMO2/TRAF2	3.19156690107845
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	43/1680	156/9376	1.53833943833944	CLDN19/SCARB1/CLDN7/PIK3CB/IFNAR2/PIK3R2/MAPK3/IRF3/AKT3/STAT2/YWHAE/RXRA/OAS3/JAK1/GRB2/RAF1/HRAS/AKT1/RB1/OAS1/APAF1/IFNAR1/IFIT1/TYK2/TBK1/SOS1/NRAS/TRAF3/PIK3R3/PPARA/EGFR/MAVS/AKT2/BAK1/E2F3/TP53/CLDN23/RIPK1/CLDN14/FADD/CXCL10/TRAF2/TRADD	3.16782210707399
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	9/1680	18/9376	2.79047619047619	HEXB/GLB1/HEXA/MAN2B1/MAN2B2/AGA/GBA2/ENGASE/MAN2C1	3.55239321474629
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	8/1680	15/9376	2.97650793650794	HEXB/GLB1/HEXA/ST3GAL5/B3GALT4/ST8SIA1/ST6GALNAC6/SLC33A1	3.57923998968927
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	53/1680	203/9376	1.45709594182501	SPP1/ITGA5/COL4A1/COL4A2/FLT1/FN1/PGF/PIK3CB/ACTN4/VAV3/PXN/PARVA/PIK3R2/MAPK3/RAC3/VASP/ERBB2/FLNB/RAPGEF1/AKT3/BCAR1/LAMA5/VAV2/PDGFB/ITGB1/TLN1/LAMB1/FLT4/PPP1R12C/MAPK9/CRKL/LAMA4/ACTN1/GRB2/PAK1/RAF1/HRAS/AKT1/PPP1R12B/PAK2/PTK2/XIAP/LAMC1/RASGRF1/ROCK2/SOS1/PIK3R3/ILK/EGFR/AKT2/TLN2/ITGA3/DOCK1	3.07614949352257
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	30/1680	101/9376	1.65770862800566	TCF7L2/POMC/MAPK3/CREB3L2/EDNRB/CAMK2G/EP300/GNAI1/ADCY7/TCF7L1/RAF1/HRAS/FZD8/MITF/GNAS/ADCY5/CALM3/TCF7/WNT7A/DVL3/NRAS/FZD5/PLCB1/ADCY9/FZD9/FZD10/MC1R/PLCB3/CALML4/FZD2	3.10488140503044
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	30/1680	101/9376	1.65770862800566	COL4A1/COL4A2/FN1/TGFB2/PIK3CB/PLCG2/PIK3R2/MAPK3/AGTR1/AKT3/TGFB1/FOXO1/SMAD3/SERPINE1/MAPK9/HRAS/AKT1/SMAD4/PRKCE/MMP2/NRAS/PIK3R3/AKT2/PLCB1/PLCD3/MAPK14/PLCG1/AGER/PLCB3/JAK2	3.10488140503044
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1680	214/9376	1.43435692033823	HLA-G/DDB1/PIK3CB/ITPR2/TAPBP/PLCG2/PXN/TAP1/PIK3R2/MAPK3/RAC3/TAP2/IRF3/PTK2B/GNG12/AKT3/FOS/MAPK9/CRKL/GNAI1/TAPBPL/SKP1/PAK1/NFATC4/RAF1/HRAS/MAP2K7/AKT1/PAK2/PTK2/ATM/PDIA3/LIMK2/CALM3/CUL4B/MAP3K7/AP1B1/TBK1/NRAS/PIK3R3/CUL1/AKT2/BAK1/MAPK14/RIPK1/PLCG1/GNA11/MTOR/CALML4/AP1G2/FADD/TAB1/ATR/TRAF2/TRADD	3.00307540915769
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1680	110/9376	1.62354978354978	TGFB2/BAMBI/MAPK3/FST/LRRC32/TGFB1/ID1/BMPR2/FBN1/SMAD3/ID3/EP300/RGMB/NOG/TFRC/INHBA/SKP1/SMAD4/E2F4/SP1/LTBP1/SMURF1/ZFYVE9/HDAC1/BMPR1B/ACVR1/NCOR1/CUL1/AMH/SMAD6/GREM1/ACVR2B	3.07347069814999
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1680	76/9376	1.76240601503759	PIK3CB/PLCG2/PIK3R2/MAPK3/AKT3/CAMK2G/PDGFB/GRB2/RAF1/HRAS/AKT1/RB1/CALM3/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLCG1/MTOR/CALML4	3.11787992288593
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	51/1680	196/9376	1.45218658892128	HLA-G/TCF7L2/PIK3CB/IFNAR2/ITPR2/PLCG2/PIK3R2/MAPK3/IRF3/CCR1/GNG12/AKT3/LYN/STAT2/IL6ST/PDGFB/FOS/EP300/MAPK9/JAK1/NFATC4/TCF7L1/RAF1/HRAS/MAP2K7/AKT1/RB1/IFNAR1/RCAN1/CALM3/TYK2/TCF7/TBK1/NRAS/TRAF3/PIK3R3/AKT2/BAK1/E2F3/PIK3C3/MAPK14/TP53/PLCG1/MTOR/CD200R1/CALML4/FADD/JAK2/TRAF2/TRADD/ANGPT2	2.98904272198645
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	42/1680	155/9376	1.51225806451613	SCARB1/CCNE1/TCF7L2/CYP11A1/POMC/ITPR2/AXIN2/MAPK3/CREB3L2/CREB5/AGTR1/ATF6B/CAMK2G/ATF4/ARNT/GNAI1/ADCY7/TCF7L1/FZD8/RB1/SP1/KMT2D/GNAS/ADCY5/TCF7/WNT7A/DVL3/FZD5/EGFR/AXIN1/E2F3/PLCB1/ADCY9/FZD9/FZD10/GNA11/ASH2L/CACNA1C/PLCB3/MEN1/CRH/FZD2	3.00450818780617
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	9/1680	19/9376	2.64360902255639	NAGLU/HEXB/GLB1/HEXA/HGSNAT/HYAL4/GUSB/ARSB/GALNS	3.35053957459761
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	34/1680	120/9376	1.58126984126984	PIK3CB/PLCG2/PIK3R2/MAPK3/MAGED1/RAPGEF1/AKT3/CAMK2G/YWHAE/SH2B2/ATF4/MAPK9/CRKL/GRB2/RAF1/HRAS/MAP2K7/BEX3/AKT1/RPS6KA1/CALM3/SOS1/NRAS/PIK3R3/AKT2/RPS6KA5/FRS2/MAPK14/TP53/PLCG1/PSEN2/CALML4/ZNF274/SH2B1	2.99408751367398
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	50/1680	193/9376	1.44584258573896	GRK3/PIK3CB/CCL3/VAV3/PLCG2/PXN/PIK3R2/MAPK3/RAC3/PTK2B/CCR1/GNG12/CCL4/CCL4L2/AKT3/LYN/BCAR1/STAT2/VAV2/PARD3/CRKL/CXCR6/ELMO1/GNAI1/ADCY7/XCR1/GRB2/PAK1/RAF1/HRAS/AKT1/PTK2/TIAM1/ROCK2/ADCY5/GRK5/SOS1/NRAS/PIK3R3/AKT2/GSK3A/PLCB1/GRK4/ADCY9/PLCG1/PLCB3/CCL8/JAK2/CCL13/CXCL10	2.92398850334366
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	15/1680	41/9376	2.0418118466899	MAPK3/ERBB2/TYMP/DAPK3/RAF1/HRAS/RB1/MMP2/NRAS/EGFR/RPS6KA5/E2F3/TP53/CDH1/FGFR3	3.1234302233168
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	38/1680	139/9376	1.52572798903734	POMC/PIK3CB/ITPR2/PIK3R2/MAPK3/CREB3L2/CREB5/ATF6B/AKT3/ATF4/FOS/KRT23/GNAI1/ADCY7/NCOA3/GRB2/RAF1/HRAS/AKT1/NCOA1/SP1/GNAS/ADCY5/CALM3/MMP2/SOS1/NRAS/PIK3R3/EGFR/AKT2/KRT15/NCOA2/PLCB1/ADCY9/KCNJ6/KCNJ5/PLCB3/CALML4	2.9174994089878
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	39/1680	144/9376	1.51150793650794	PIK3CB/ITPR2/PIK3R2/CACNA1A/XBP1/AKT3/PSMC4/PSMA2/WIPI1/MAPK9/PSMA6/AKT1/ATXN2/PUM1/ATG13/SP1/SLC1A6/PIK3R3/NFYA/ATG2B/AKT2/BEAN1/VLDLR/PUM2/WIPI2/PIK3C3/PLCB1/SLC25A4/GRIN2D/ULK2/KAT5/MTOR/PLCB3/ULK1/ATXN1L/PSMA8/TBP/GRIN3B/TRAF2	2.88997093012353
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	22/1680	70/9376	1.75401360544218	POMC/PRKAG2/ACSL4/AKT3/RXRB/MAPK9/PRKAG1/RXRA/ACSL5/AKT1/CPT1B/STK11/CPT1A/SLC2A1/PPARA/AKT2/CAMKK2/MTOR/JAK2/PRKAB2/TRAF2/TRADD	2.95838320175811
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	51/1680	200/9376	1.42314285714286	CLDN19/CLDN7/TUBB2A/CTTN/TUBB/SEC24D/BAIAP2L1/TNFSF10/MAPK3/ARPC1B/IL1R1/MYH10/TJP1/ARHGEF2/MYO10/MYH9/ITGB1/CYTH3/SEC24A/FOS/MAPK9/CYFIP1/TUBA1C/CYTH1/CYFIP2/PAK1/PAK2/CASP7/GNA12/NCKAP1/LPAR2/TUBB6/TMBIM6/ROCK2/RAB1A/WIPF2/SEC24C/MAP3K7/MYO1C/ACTR3B/ARPC2/BAK1/MAPK14/CYTH2/CLDN23/RIPK1/CLDN14/FADD/TAB1/TRAF2/TRADD	2.82607093869742
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	31/1680	109/9376	1.58724333770205	SPP1/PIK3CB/IFNAR2/CCL3/PIK3R2/MAPK3/IRF3/CCL4/CCL4L2/AKT3/STAT2/CD14/FOS/MAPK9/JAK1/TICAM2/MAP2K7/AKT1/IFNAR1/TYK2/MAP3K7/TBK1/TRAF3/PIK3R3/AKT2/MAPK14/RIPK1/FADD/TAB1/CXCL10/TLR7	2.88117418835713
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	56/1680	224/9376	1.3952380952381	CCNE1/HLA-G/TGFB2/PIK3CB/PIK3R2/MAPK3/IL1R1/CREB3L2/CANX/CREB5/IL2RB/CRTC3/ATF6B/AKT3/TGFB1/SMAD3/TLN1/ATF4/FOS/EP300/MAPK9/ADCY7/JAK1/NFATC4/HRAS/AKT1/RB1/SRF/SMAD4/ATM/XIAP/IL1R2/NRP1/ADCY5/DLG1/NRAS/MAP3K14/PIK3R3/SLC2A1/HLA-DQA1/AKT2/TLN2/MSX2/TCF3/KAT2A/E2F3/TP53/NFYB/ADCY9/SLC25A4/TRRAP/KAT5/VAC14/TBP/RANBP3/ATR	2.79725816780389
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	33/1680	119/9376	1.54765906362545	MMP14/DAB2IP/PIK3CB/CEBPB/PIK3R2/MAPK3/CREB3L2/CREB5/ATF6B/AKT3/ITCH/ATF4/FOS/MAPK9/MAP2K7/AKT1/CASP7/XIAP/FRMD8/MAP3K7/RHBDF1/MAP3K14/TRAF3/PIK3R3/AKT2/RPS6KA5/MAPK14/RIPK1/FADD/TAB1/CXCL10/TRAF2/TRADD	2.80903000316981
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	32/1680	115/9376	1.55296066252588	FGFR1/GCM1/MMP14/ITPR2/WNK2/MAPK3/CREB3L2/CREB5/GATA3/ATF6B/RXRB/ATF4/FOS/RXRA/GNAI1/SGK1/ADCY7/MMP15/RAF1/WNK1/GNA12/SP1/GNAS/PTH1R/ADCY5/EGFR/PLCB1/ADCY9/GNA11/LRP6/PLD2/PLCB3	2.78754549681048
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1680	80/9376	1.67428571428571	PIK3CB/PLCG2/PIK3R2/MAPK3/ERBB2/ERBB3/AKT3/PDGFB/JAK1/GRB2/RAF1/HRAS/AKT1/NF1/SOS1/NRAS/PIK3R3/EGFR/AKT2/EIF4EBP1/PLCG1/MTOR/JAK2/FGFR3	2.82975375012313
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	30/1680	107/9376	1.56475300400534	ITPR2/PRKAG2/CREB3L2/CREB5/LDHA/AKT3/CAMK2G/FOXO1/ATF4/EP300/PHKA2/PRKAG1/PFKL/AKT1/GYS1/CPT1B/GNAS/CALM3/CPT1A/SLC2A1/PHKB/PPARA/ACACA/AKT2/SIK2/PLCB1/PLCB3/CALML4/PYGB/PRKAB2	2.74499619627202
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	21/1680	68/9376	1.72352941176471	CSF1R/TCF7L2/PIK3CB/PIK3R2/MAPK3/CEBPA/AKT3/CD14/GRB2/TCF7L1/RAF1/HRAS/AKT1/PPARD/TCF7/SOS1/NRAS/PIK3R3/AKT2/EIF4EBP1/MTOR	2.79762956345087
NA	NA	hsa04519	Cadherin signaling	92/1680	404/9376	1.27090994813767	FGFR1/KRT7/TCF7L2/LIMD1/ACTN4/VAV3/LHFPL6/NCSTN/AXIN2/MAPK3/ARPC1B/RAC3/MPDZ/ANKRD6/PKP2/PTK2B/VASP/ERBB2/CTNND2/TJP1/LIMA1/AMOTL2/TMC4/TEAD1/FAT2/EVL/FMN1/VAV2/YWHAE/GABRE/RERE/ADAM10/CTNND1/EP300/KRT23/FLT4/MAPK9/CYFIP1/TMC1/ACTN1/CYFIP2/TEAD3/TCF7L1/RAF1/HRAS/FZD8/PTK2/MRAS/TAOK3/TAOK1/NCKAP1/CSNK1A1/ROCK2/ATN1/WWTR1/TCF7/WNT7A/DVL3/SAV1/MYO1C/LATS1/NRAS/ACTR3B/MOB1B/FZD5/PCDH12/DAAM2/EGFR/ARPC2/CDH8/TAOK2/KRT15/AXIN1/RYK/MAPK14/FZD9/DSP/FZD10/SCN1B/LRP6/PSEN2/CDH23/LHFPL5/AJUBA/CELSR2/MYO7A/STK3/FAT1/CDH1/FZD2/CTNNA3/WTIP	2.60063110583555
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	35/1680	130/9376	1.5025641025641	COL4A1/COL4A2/PIK3CB/PIK3R2/MAPK3/CREB3L2/EDNRB/CREB5/GNG12/ATF6B/AKT3/TGFB1/ATF4/FOS/MAPK9/GNAI1/ADCY7/GRB2/RAF1/HRAS/MAP2K7/AKT1/GNAS/ADCY5/MMP2/SOS1/NRAS/PIK3R3/EGFR/AKT2/NOS2/PLCB1/MAPK14/ADCY9/PLCB3	2.69583896047831
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	12/1680	32/9376	2.09285714285714	GAA/AKR1B1/GALM/GLB1/UGP2/PFKL/GALK1/GALE/GALT/HK1/B4GALT2/PGM1	2.89320841083738
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	38/1680	144/9376	1.47275132275132	TCF7L2/FASN/PRKAG2/C1QA/IRF3/LPIN2/AKT3/SREBF1/FOXO1/CD14/C1QB/MAPK9/PRKAG1/ACADVL/TCF7L1/MAP2K7/AKT1/CPT1B/C3AR1/CPT1A/MAP3K7/TCF7/TBK1/MAP3K14/TRAF3/PPARA/ACACA/AKT2/CAMKK2/ALDH1B1/MLYCD/MAPK14/RIPK1/FADD/ALDH3A2/PRKAB2/TAB1/TRADD	2.67099976836346
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	41/1680	158/9376	1.44822182037372	PIK3CB/GRB10/CASTOR1/PIK3R2/MAPK3/SESN2/LPIN2/AKT3/INSR/SGK1/SLC38A9/GRB2/RAF1/HRAS/FZD8/AKT1/TSC1/RPS6KA1/STK11/WNT7A/DVL3/SOS1/CASTOR2/NRAS/FZD5/PIK3R3/DEPTOR/WDR59/AKT2/EIF4EBP1/FZD9/ULK2/FZD10/LRP6/STRADA/MTOR/ULK1/ATP6V1C2/DEPDC5/FZD2/ATP6V1E2	2.65467240988878
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	60/1680	248/9376	1.35023041474654	TCF7L2/TUBB2A/PIK3CB/TUBB/DNM2/GSDMD/TNFSF10/MAPK3/ARPC1B/AKT3/PKN1/CYTH3/CD14/FOS/DYNLRB1/MAPK9/CYFIP1/PLEKHM1/TUBA1C/ELMO1/SNX9/CYTH1/RHOB/SKP1/CYFIP2/PAK1/TCF7L1/RAF1/HRAS/MAP2K7/AKT1/PLEKHM2/CASP7/DYNLL2/DYNC1LI2/NCKAP1/TUBB6/ROCK2/PIK3C2A/VPS39/MAP3K7/TCF7/RILP/ACTR3B/RAB5C/PIK3C2B/ARPC2/AKT2/FBXO22/BAK1/PIK3C3/MAPK14/CYTH2/RIPK1/VPS18/FADD/TAB1/ELMO2/TRAF2/TRADD	2.61155774249214
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	22/1680	73/9376	1.68193085453359	PIK3CB/PLCG2/PIK3R2/MAPK3/ERBB2/AKT3/RXRB/RXRA/GRB2/RAF1/HRAS/AKT1/RB1/SOS1/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/PLCG1	2.732738088926
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	88/1680	388/9376	1.26578301423662	BACE2/SLC39A1/TUBB2A/LRP1/MME/PIK3CB/SLC39A7/TUBB/ITPR2/NCSTN/AXIN2/PIK3R2/MAPK3/CSNK2B/NDUFA6/XBP1/NDUFS1/CHRM5/CSNK1E/AKT3/PSMC4/PSMA2/WIPI1/INSR/NDUFS3/SLC39A14/ADAM10/ATF4/SLC39A4/NDUFA7/MAPK9/PSMA6/TUBA1C/RAF1/HRAS/MAP2K7/FZD8/AKT1/APAF1/CASP7/ATG13/TUBB6/CSNK1A1/SDHA/FRAT2/CALM3/SLC39A11/APOE/WNT7A/DVL3/FRAT1/NRAS/SLC11A2/FZD5/PIK3R3/NDUFA13/ATG2B/AKT2/MT-ND2/AXIN1/WIPI2/NOS2/CSNK2A2/SLC39A9/PIK3C3/PLCB1/FZD9/SLC39A13/SLC25A4/GRIN2D/MT-ND5/ULK2/FZD10/LRP6/CACNA1C/COX4I2/MAPT/AGER/MTOR/PSEN2/PLCB3/CALML4/ULK1/FADD/PSMA8/IDE/FZD2/TRAF2	2.49815455068066
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	13/1680	37/9376	1.96087516087516	PPARG/TCF7L2/MAPK3/RXRB/RXRA/TCF7L1/HRAS/NCOA4/TCF7/NRAS/BAK1/TP53/CDH1	2.73605857446076
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1680	62/9376	1.71029185867896	PIK3CB/PRKAG2/PIK3R2/EIF4EBP2/AKT3/FOXO1/INSR/PRKAG1/ADCY7/HRAS/AKT1/ADCY5/HDAC1/NRAS/PIK3R3/AKT2/ADCY9/MTOR/PRKAB2	2.62163553063798
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	45/1680	180/9376	1.3952380952381	ITGA5/HLA-G/PIK3CB/IFNAR2/TAPBP/TAP1/PIK3R2/TAP2/IRF3/AKT3/SRSF1/NXF1/STAT2/DAXX/SRSF6/OAS3/TAPBPL/JAK1/HCFC1/AKT1/OAS1/APAF1/TSC1/IFNAR1/PDIA3/TYK2/SRSF5/MAP3K7/SRSF7/TBK1/TRAF3/POU2F1/PIK3R3/HLA-DQA1/MAVS/AKT2/BAK1/EIF4EBP1/TP53/MTOR/FADD/JAK2/TAB1/TRAF2/TRADD	2.50151619246644
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	40/1680	157/9376	1.42189869578405	CCNE1/HLA-G/TGFB2/PIK3CB/ITPR2/PIK3R2/MAPK3/RAD50/AKT3/TGFB1/FOXO1/IGFBP3/SMAD3/SERPINE1/NFATC4/RAF1/HRAS/AKT1/RB1/TSC1/MRAS/ATM/E2F4/CALM3/RBL2/TRPM7/LIN37/NRAS/ZFP36L1/PIK3R3/AKT2/EIF4EBP1/TRPV4/E2F3/MAPK14/TP53/SLC25A4/MTOR/CALML4/ATR	2.49071393825831
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	28/1680	103/9376	1.51715210355987	COL4A1/COL4A2/FN1/TGFB2/SERPINB6/PIK3CB/ACTN4/PIK3R2/IL1R1/TGFB1/LAMA5/CD14/LAMB1/LAMA4/ACTN1/PTK2/IL1R2/PRDX1/LAMC1/GNAS/RAB5C/PIK3R3/NOS2/PLCB1/GNAL/GNA11/PLCB3/C9	2.46566759537671
NA	NA	hsa04518	Integrin signaling	39/1680	154/9376	1.41335807050093	SPP1/ITGA5/COL4A1/COL4A2/FLT1/FN1/PGF/PIK3CB/ACTN4/PXN/PARVA/PIK3R2/RAC3/LIMS2/FERMT2/ERBB2/FLNB/AKT3/TGFB1/LAMA5/FBN1/PDGFB/ITGB1/TLN1/LAMB1/FLT4/LAMA4/ACTN1/AKT1/PTK2/LAMC1/PIK3R3/ILK/EGFR/AKT2/TLN2/ITGA3/MTOR/CDH1	2.41647314101711
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	36/1680	140/9376	1.43510204081633	SPP1/ITPR2/PRKAG2/MAPK3/AGTR1/GNG12/AKT3/HDAC5/SMAD3/SERPINE1/SLC9A1/PRKAG1/GNAI1/ADCY7/RAF1/HRAS/AKT1/SMAD4/MRAS/NOTCH3/PRKCE/ADCY5/CALM3/NRAS/AKT2/NOS2/TFAM/PIK3C3/PLCB1/ADCY9/MTOR/PLCB3/CALML4/MEF2B/PRKAB2/CDH1	2.42337668672394
Human Diseases	Infectious disease: viral	hsa05162	Measles	35/1680	136/9376	1.43627450980392	CCNE1/PIK3CB/IFNAR2/PIK3R2/CSNK2B/IRF3/IL2RB/ADAR/AKT3/CBLB/STAT2/FOS/MAPK9/OAS3/JAK1/AKT1/OAS1/APAF1/CD46/IFNAR1/TYK2/MAP3K7/TBK1/TRAF3/PIK3R3/MAVS/AKT2/CSNK2A2/BAK1/TP53/FCGR2B/FADD/CD209/TLR7/TRADD	2.39442400236868
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1680	142/9376	1.4148893360161	PPARG/CSF1R/TGFB2/PIK3CB/IFNAR2/ITPR2/PLCG2/PIK3R2/MAPK3/IL1R1/AKT3/TGFB1/STAT2/FHL2/FOS/MAPK9/JAK1/GRB2/MAP2K7/AKT1/IFNAR1/MITF/FOSB/TYK2/MAP3K7/FCGR3A/MAP3K14/PIK3R3/AKT2/LILRB5/GAB2/TNFRSF11A/MAPK14/FCGR2B/TAB1/TRAF2	2.3274976911898
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	32/1680	125/9376	1.42872380952381	PIK3CB/PIK3R2/MAPK3/RAC3/SGPP1/AKT3/ACER2/S1PR2/PPP2R3B/MAPK9/GNAI1/ABCC1/RAF1/HRAS/AKT1/CERS5/GNA12/SPTLC2/PPP2R5E/ROCK2/PRKCE/NRAS/PIK3R3/AKT2/GAB2/PLCB1/MAPK14/TP53/PLD2/PLCB3/TRAF2/TRADD	2.25447808818165
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1680	116/9376	1.44334975369458	CLDN19/ESAM/CLDN7/PIK3CB/F11R/ACTN4/VAV3/PLCG2/PXN/PIK3R2/JAM2/PTK2B/VASP/BCAR1/VAV2/ITGB1/CTNND1/GNAI1/ACTN1/PTK2/CD99L2/ROCK2/MMP2/RAPGEF3/PIK3R3/MAPK14/CLDN23/PLCG1/CLDN14/CTNNA3	2.24480035490442
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	15/1680	49/9376	1.70845481049563	GALNT7/PLOD3/GALNT2/GALNT6/COLGALT1/GALNT3/GALNT1/EOGT/GALNT14/B4GALT2/POFUT2/GALNT12/B4GALT3/POMT1/POMT2	2.32298793790819
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	26/1680	98/9376	1.48066083576288	SCARB1/CYP11A1/POMC/ITPR2/CREB3L2/CREB5/AGTR1/ATF6B/PRKD3/CAMK2G/DAGLB/ATF4/ADCY7/ATP1A1/GNAS/PRKCE/ADCY5/CALM3/PLCB1/ADCY9/ATF1/GNA11/CACNA1C/KCNJ5/PLCB3/CALML4	2.23476746775045
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/1680	17/9376	2.29803921568627	MYH10/DAG1/MYH9/TFRC/LAMP2/LAMP1/CD209	2.50267986715984
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1680	71/9376	1.57209926224011	PIK3CB/PIK3R2/MAPK3/CGA/AKT3/FOS/MAPK9/SOCS7/GRB2/RAF1/HRAS/AKT1/GALT/SOS1/NRAS/PIK3R3/AKT2/TNFRSF11A/MAPK14/JAK2	2.26073742012815
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	14/1680	45/9376	1.7362962962963	ABCA1/TAP1/TAP2/ABCA7/ABCD1/ABCC1/ABCC10/ABCG1/ABCD4/ABCB6/ABCG2/ABCB10/ABCA4/ABCC3	2.31314324317796
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1680	33/9376	1.86031746031746	SNAP23/SNAP29/STX16/BET1/YKT6/VAMP7/STX5/STX6/GOSR2/BET1L/STX1A	2.31302476215462
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/1680	104/9376	1.4489010989011	LPCAT1/DGKZ/LPIN2/CHKB/AGPAT1/CRLS1/GDPD5/PLPP2/GPAT4/LYPLA1/PLA2G10/LCAT/PLPP5/GPAM/LYPLA2/PTDSS2/LPCAT3/DGKH/LPCAT4/PLD2/CDS2/PNPLA6/DGKQ/LCLAT1/GPD2/PLA2G15/PLA2G4B	2.1507422976961
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/1680	105/9376	1.43510204081633	PIK3CB/ITPR2/PLCG2/PIK3R2/MAPK3/KSR1/AKT3/CBLB/STAT2/MAPK9/EGR3/PAK1/NFATC4/RAF1/HRAS/AKT1/MRAS/CALM3/PLK3/NRAS/MAP3K14/PIK3R3/AKT2/MAPK14/IL17D/CALML4/CD209	2.09474049697078
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	47/1680	201/9376	1.30499881544658	HPGD/FLT1/PPARG/CSF1R/ASPSCR1/CEBPB/CEBPA/IL2RB/MYCN/FOXO1/ARNT2/IGFBP3/CD14/RXRB/RXRA/EWSR1/DOT1L/BMP2K/ETV5/ETV4/AFF1/PTK2/MAF/ATM/MITF/IL1R2/SP1/SIX4/BMI1/HDAC1/FUT8/NCOR1/MLLT1/FUS/TCF3/BAK1/TP53/ATF1/ZBTB17/LDB1/MLLT3/MEN1/PTCRA/ELANE/ETV7/LYL1/DEFA3	2.04221233229091
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	50/1680	216/9376	1.29188712522046	PPARG/ABCA1/PIK3CB/HSPA2/CCL3/VAV3/TNFSF10/PIK3R2/MAPK3/IRF3/XBP1/AKT3/LYN/CAMK2G/VAV2/CD14/RXRB/ATF4/FOS/MAPK9/RXRA/TICAM2/HRAS/MAP2K7/AKT1/APAF1/CASP7/PTK2/ROCK2/CALM3/MAP3K7/ABCG1/TBK1/NRAS/TRAF3/POU2F1/PIK3R3/AKT2/VLDLR/PLCB1/CYP2J2/MAPK14/TP53/PLCG1/AGER/PLCB3/CALML4/JAK2/TAB1/TRAF2	2.02769125201468
Human Diseases	Cancer: specific types	hsa05218	Melanoma	20/1680	73/9376	1.52902804957599	FGFR1/PIK3CB/PIK3R2/MAPK3/AKT3/PDGFB/RAF1/HRAS/AKT1/RB1/MITF/FGF18/NRAS/PIK3R3/EGFR/AKT2/BAK1/E2F3/TP53/CDH1	2.12000247763438
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	29/1680	115/9376	1.40737060041408	PIK3CB/ITPR2/KCNJ2/PIK3R2/MAPK3/CACNA1A/CREB3L2/CREB5/GNG12/CHRM5/AKT3/CAMK2G/ATF4/FOS/GNAI1/ADCY7/HRAS/AKT1/ADCY5/NRAS/PIK3R3/AKT2/PLCB1/ADCY9/GNA11/CACNA1C/KCNJ6/PLCB3/JAK2	2.05360735342381
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	17/1680	60/9376	1.58126984126984	PIK3CB/PLCG2/PXN/PIK3R2/MAPK3/RAC3/AKT3/RAF1/HRAS/AKT1/PTK2/NRAS/PIK3R3/AKT2/MAPK14/PLCG1/PLA2G4B	2.11031081833892
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	8/1680	22/9376	2.02943722943723	AOC1/MAOA/HNMT/ALDH3B2/CARNMT1/CNDP2/ALDH1B1/ALDH3A2	2.25850094993387
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	18/1680	65/9376	1.54549450549451	SCARB1/CYP11A1/POMC/ITPR2/CREB3L2/CREB5/AGTR1/ATF6B/ATF4/ADCY7/SP1/GNAS/ADCY5/PLCB1/ADCY9/GNA11/CACNA1C/PLCB3	2.06184799635169
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	47/1680	205/9376	1.27953542392567	CCNE1/HLA-G/PIK3CB/IFNAR2/TAPBP/PLCG2/TAP1/PIK3R2/TAP2/IRF3/NCOR2/AKT3/PSMC4/LYN/STAT2/MAPK9/OAS3/TAPBPL/JAK1/ISG15/MAP2K7/AKT1/RB1/OAS1/APAF1/IFNAR1/PDIA3/TYK2/MAP3K7/TBK1/HDAC1/MAP3K14/TRAF3/PIK3R3/HLA-DQA1/MAVS/AKT2/BAK1/E2F3/MAPK14/TP53/RIPK1/FADD/TAB1/CXCL10/TRAF2/TRADD	1.8906589056805
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	47/1680	205/9376	1.27953542392567	CCNE1/HLA-G/DDB1/PIK3CB/ACTN4/PXN/PIK3R2/MAPK3/IRF3/CREB3L2/CREB5/ATF6B/LYN/HDAC5/IL6ST/YWHAE/MRPS18B/ATF4/EP300/EGR3/ACTN1/JAK1/GRB2/HRAS/RB1/SRF/SCRIB/CHD4/DNAJA3/GTF2H4/DLG1/RBL2/HDAC1/HDAC10/NRAS/TRAF3/PIK3R3/SND1/BAK1/KAT2A/HDAC6/H2BC15/TP53/VAC14/TBP/TRAF2/TRADD	1.8906589056805
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	8/1680	23/9376	1.94120082815735	MGAT5B/B4GALT2/B4GALT3/B4GAT1/CRPPA/POMT1/CHST10/POMT2	2.11143881503565
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	8/1680	23/9376	1.94120082815735	MME/PRCP/AGTR1/CTSA/LNPEP/THOP1/ENPEP/PREP	2.11143881503565
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/1680	105/9376	1.38195011337868	PLCG2/CSNK2B/IL1R1/CCL4/CCL4L2/LYN/CD14/ERC1/TICAM2/ATM/XIAP/TRIM25/MAP3K7/MAP3K14/TRAF3/TNFRSF11A/CSNK2A2/PPP1R13L/RIPK1/CARD14/PLCG1/CCL13/TAB1/TRAF2/TRADD/PIDD1	1.83884766161016
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	26/1680	105/9376	1.38195011337868	CSNK2B/ATF4/MAPK9/ATG9A/RHOT2/HRAS/MRAS/MITF/PINK1/SP1/SMURF1/TOMM40/SIAH1/TBK1/CITED2/NRAS/RAB5C/MFN2/CSNK2A2/MFN1/TP53/TOMM70/NLRX1/ULK1/CCZ1B/TRAF2	1.83884766161016
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	53/1680	238/9376	1.24281712685074	FGFR1/FLT1/PGF/CSF1R/RASGRF2/PIK3CB/EFNA1/PLCG2/PIK3R2/MAPK3/RAC3/RGL2/RASA1/KSR1/GNG12/AKT3/INSR/PDGFB/RALBP1/FLT4/MAPK9/GRB2/PAK1/RAF1/HRAS/AKT1/PAK2/TIAM1/PLA2G10/MRAS/RASGRF1/NF1/FOXO4/FGF18/CALM3/TBK1/SOS1/NRAS/RAB5C/PIK3R3/EGFR/AKT2/TEK/RGL1/GAB2/EFNA4/PLCG1/PLD2/CALML4/RALGAPA2/PLA2G4B/FGFR3/ANGPT2	1.77276009523154
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/1680	91/9376	1.41057038199895	PIK3CB/INPPL1/VAV3/PLCG2/PIK3R2/MAPK3/RAC3/AKT3/LYN/VAV2/FOS/GRB2/RAF1/HRAS/AKT1/CD22/SOS1/NRAS/BANK1/PIK3R3/AKT2/LILRB5/FCGR2B	1.83876025733345
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	16/1680	59/9376	1.5134786117837	MGLL/PIK3CB/PIK3R2/CGA/AKT3/INSR/PTGER3/GNAI1/ADCY7/AKT1/GNAS/ADCY5/PIK3R3/AKT2/ADCY9/FABP4	1.84849408844025
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/1680	50/9376	1.56266666666667	PYCR1/AOC1/MAOA/SAT1/ALDH18A1/OAT/P4HA2/PYCR3/CNDP2/ALDH1B1/NOS2/P4HA1/GATM/ALDH3A2	1.86378680920974
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/1680	20/9376	1.95333333333333	UGDH/GNE/UGP2/GMPPA/NANS/CYB5R2/TGDS	1.99398744380987
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/1680	55/9376	1.52207792207792	GM2A/SGPP1/PSAP/HEXB/GLB1/ACER2/HEXA/ARSA/UGCG/PLPP2/CERS5/SPTLC2/ACER3/SMPD4/GBA2	1.81423344255157
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1680	51/9376	1.53202614379085	TJP2/PLCG2/TJP1/SEC61A1/KDELR3/PDIA4/KDELR2/GNAS/KDELR1/ATP6V0A1/ADCY9/PLCG1/ATP6V1C2/ATP6V1E2	1.77992372305123
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	17/1680	65/9376	1.4596336996337	DGKZ/MGLL/AKR1B1/LIPG/LPIN2/AGPAT1/ABHD16A/PLPP2/GPAT4/PLPP5/GPAM/ALDH1B1/PNPLA3/DGKH/DGKQ/LCLAT1/ALDH3A2	1.73731323248865
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1680	142/9376	1.29698189134809	PIK3CB/HMOX1/PIK3R2/RAC3/IL1R1/ARHGEF2/AKT3/BMPR2/GSTA3/PDGFB/FOS/MAPK9/MAP2K7/AKT1/SDC4/PTK2/IL1R2/CTSL/DUSP1/CALM3/MMP2/MAP3K7/GPC1/BMPR1B/PIK3R3/ACVR1/AKT2/TRPV4/MAPK14/TP53/CALML4/ACVR2B/GSTT1	1.66604587400395
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1680	56/9376	1.49489795918367	GRK3/CSNK1E/GLI3/BOC/SCUBE2/HHAT/CSNK1G2/CSNK1G3/CSNK1A1/SMURF1/MGRN1/CSNK1G1/CUL1/PTCH1/DHH	1.73543946668746
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	22/1680	89/9376	1.37956126270733	TUBB2A/TUBB/ITPR2/MAPK3/TJP1/PDGFB/TUBA1C/GNAI1/ADCY7/GRB2/RAF1/HRAS/TUBB6/GNAS/ADCY5/SOS1/NRAS/EGFR/PLCB1/ADCY9/GNA11/PLCB3	1.68091949023254
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/1680	99/9376	1.35295815295815	IL1RAP/PIK3CB/ITPR2/PLCG2/PIK3R2/IL1R1/CAMK2G/MAPK9/ADCY7/GNAS/PRKCE/ADCY5/CALM3/PIK3R3/F2RL1/TRPV4/PLCB1/CYP2J2/MAPK14/ADCY9/PLCG1/PLCB3/CALML4/PLA2G4B	1.64947138812427
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1680	90/9376	1.3642328042328	PIK3CB/PIK3R2/MAPK3/CSNK2B/CD274/AKT3/FOS/JAK1/TICAM2/RAF1/HRAS/AKT1/NRAS/BATF3/PIK3R3/EGFR/AKT2/CSNK2A2/MAPK14/PLCG1/MTOR/JAK2	1.62216012673289
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1680	57/9376	1.46867167919799	FASN/ACSL4/FADS1/ACADVL/ELOVL2/ACSL5/FADS2/CPT1B/CPT1A/CPT2/ACACA/TECR/PPT2/HSD17B8/ACADS	1.65817068284271
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1680	154/9376	1.26839826839827	ITPR2/PRKAG2/KCNJ2/MAPK3/CAMK2G/FOS/PPP1R12C/PRKAG1/GNAI1/ADCY7/EEF2K/NFATC4/RAF1/HRAS/EEF2/PPP1R12B/RCAN1/GNAS/ROCK2/ADCY5/CALM3/NRAS/EGFR/CAMKK2/PLCB1/ADCY9/CACNA1C/KCNJ6/KCNJ5/CACNB3/PLCB3/CALML4/TRPM2/PRKAB2/PLA2G4B	1.56904449910447
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	18/1680	72/9376	1.3952380952381	IRF3/ADAR/MAPK9/ISG15/OTUD5/TRIM25/MAP3K7/TBK1/TRAF3/MAVS/MAPK14/RIPK1/NLRX1/FADD/DHX58/CXCL10/TRAF2/TRADD	1.57288852678804
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	49/1680	226/9376	1.21002949852507	POMC/PIK3CB/VAV3/PIK3R2/MAPK3/RAC3/CREB3L2/CREB5/CGA/GLI3/AKT3/CAMK2G/VAV2/HCAR1/HCAR2/FOS/EP300/PTGER3/MAPK9/SLC9A1/GNAI1/ADCY7/ATP1A1/PDE10A/PAK1/RAF1/AKT1/TIAM1/GNAS/ROCK2/ADCY5/CALM3/RAPGEF3/PIK3R3/PPARA/AKT2/AMH/PTCH1/SST/ADCY9/GRIN2D/SSTR2/CACNA1C/PLD2/GIPR/CALML4/EDN3/CRH/GRIN3B	1.4932472290588
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1680	126/9376	1.28450491307634	PIK3CB/ITPR2/PLCG2/APBB1IP/PIK3R2/MAPK3/VASP/AKT3/LYN/SNAP23/ITGB1/TLN1/GNAI1/ADCY7/AKT1/GNAS/ROCK2/ADCY5/PRKCI/PIK3R3/AKT2/TLN2/PLCB1/MAPK14/ADCY9/PLCB3/PLA2G4B/P2RY1/GP1BB	1.50214524129273
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/1680	63/9376	1.41738473167045	TCF7L2/AXIN2/GLI3/TCF7L1/FZD8/TCF7/WNT7A/DVL3/FZD5/AXIN1/BAK1/PTCH1/TP53/FZD9/FZD10/FZD2	1.55299401101407
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/1680	54/9376	1.44691358024691	CENPX/BRCA2/RAD51C/FANCE/FAN1/TOP3B/RPA4/EME2/REV1/RMI1/FAAP100/MUS81/ATR/POLI	1.53876972059825
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	19/1680	78/9376	1.35946275946276	TOB2/LSM2/CNOT6/DCP2/PFKL/EXOSC4/CNOT3/PARN/CNOT1/EDC4/PABPC1L/TENT4A/PAN2/PABPC3/CNOT8/PNPT1/DCP1B/EXOSC10/CNOT10	1.48940972041012
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/1680	83/9376	1.34480780263913	ECH1/IDH2/ACSL4/PIPOX/ABCD1/FAR2/PEX6/ACSL5/AGXT/PRDX1/IDH1/ABCD4/FAR1/MLYCD/NOS2/PHYH/PEX26/AMACR/CRAT/PRDX5	1.47416437610284
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	24/1680	103/9376	1.3004160887656	TGFB2/PIK3CB/CCL3/PIK3R2/MAPK3/C1QA/AKT3/TGFB1/C1QB/FOS/SERPINE1/MAPK9/GNAI1/AKT1/GNAS/PIK3R3/AKT2/NOS2/PLCB1/MAPK14/GNAL/GNA11/PLCB3/FADD	1.43231790047898
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1680	69/9376	1.37501725327812	CREB3L2/CREB5/ATF6B/CAMK2G/ATF4/FOS/MAOA/FOSB/GNAS/ADCY5/CALM3/HDAC1/GRIN2D/CACNA1C/CALML4/STX1A/GRIN3B	1.46075938954145
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	11/1680	41/9376	1.49732868757259	RAD50/POLD4/BRCA2/ATM/POLD1/RAD51C/TOP3B/RPA4/BARD1/XRCC2/MUS81	1.49102878664911
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1680	32/9376	1.56964285714286	WIPI1/ATG9A/ATG13/ATG16L1/ATG2B/WIPI2/PIK3C3/ULK2/MTOR	1.50806124682537
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/1680	60/9376	1.3952380952381	ITPR2/MAPK3/CACNA1A/LYN/GNAI1/RAF1/HRAS/GNA12/GNAS/NRAS/PLCB1/GNA11/PLCB3/CRH/PLA2G4B	1.43491915283012
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	18/1680	75/9376	1.33942857142857	PIK3CB/PIK3R2/MAPK3/ERBB2/AKT3/GSTA3/AKT1/APAF1/ATM/XIAP/PIK3R3/TOP2B/AKT2/BAK1/TP53/FADD/ATP7B/GSTT1	1.37886565847036
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	18/1680	75/9376	1.33942857142857	ITPR2/GPX3/CREB3L2/CANX/CREB5/ATF6B/CGA/PDIA4/ATF4/GPX8/TTR/ADCY7/ATP1A1/GNAS/ADCY5/PLCB1/ADCY9/PLCB3	1.37886565847036
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	34/1680	155/9376	1.2242089093702	ITGA5/SCARB1/HLA-G/TUBB2A/MRC2/TUBB/TAP1/TAP2/CANX/SEC61A1/ITGB1/CD14/COLEC12/TFRC/TUBA1C/LAMP2/MRC1/HGS/CTSL/DYNC1LI2/TUBB6/RILP/LAMP1/FCGR3A/PIKFYVE/RAB5C/ATP6V0A1/HLA-DQA1/PIK3C3/FCGR2B/MARCO/CD209/ATP6V1C2/ATP6V1E2	1.3150354296875
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1680	42/9376	1.46167800453515	HMOX1/ACSL4/SLC39A14/SAT1/TFRC/ACSL5/NCOA4/SLC11A2/LPCAT3/GPX4/TP53	1.40099853344327
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1680	47/9376	1.42492401215805	PIK3CB/PIK3R2/MAPK3/CACNA1A/INSR/MAPK9/PRKCE/HK1/PIK3R3/CACNA1C/MTOR/MAFA	1.36442731595946
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	18/1680	76/9376	1.3218045112782	ANGPTL4/PPARG/ACSL4/PLTP/SLC27A1/PLIN2/RXRB/RXRA/FABP7/ACSL5/FADS2/CPT1B/PPARD/CPT1A/CPT2/PPARA/ILK/FABP4	1.3160282120268
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/1680	76/9376	1.3218045112782	CA2/ITPR2/KCNJ2/CAMK2G/SLC9A1/GNAI1/ADCY7/ATP1A1/GNAS/ADCY5/CALM3/SLC4A2/PLCB1/SST/ADCY9/SSTR2/PLCB3/CALML4	1.3160282120268
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	96/1680	480/9376	1.11619047619048	TUBB2A/HIP1/TUBB/ITPR2/GPX3/AXIN2/MAPK3/CSNK2B/NDUFA6/XBP1/NDUFS1/CHRM5/DNAH11/CSNK1E/PSMC4/CAMK2G/PSMA2/WIPI1/NDUFS3/ATF4/NDUFA7/GPX8/MAPK9/PSMA6/DAXX/MAP3K10/TUBA1C/RAF1/HRAS/MAP2K7/FZD8/ATXN2/APAF1/CASP7/ATG13/SMCR8/PINK1/TUBB6/CSNK1A1/SDHA/FRAT2/TOMM40/RAB1A/CALM3/WNT7A/TBK1/UBE2L6/DVL3/FRAT1/HTT/NRAS/FZD5/GPR37/DNAH14/NDUFA13/ATG2B/MFN2/MT-ND2/FUS/AXIN1/WIPI2/NOS2/CSNK2A2/BAK1/UBA7/PIK3C3/PLCB1/MAPK14/MFN1/FZD9/SLC25A4/GRIN2D/MT-ND5/ULK2/PLCG1/FZD10/LRP6/CACNA1C/COX4I2/SPG11/MAPT/AGER/MTOR/PSEN2/ALS2/PLCB3/CALML4/ULK1/ATXN1L/FADD/VAPB/STX1A/DNAH8/PSMA8/FZD2/TRAF2	1.22096021510079
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	40/1680	187/9376	1.19378660555131	CTSB/IFNAR2/ITPR2/GSDMD/MAPK3/IRF3/PKN1/STAT2/YWHAE/RNF31/MAPK9/OAS3/JAK1/ANTXR2/OAS1/IFNAR1/XIAP/ATG16L1/P2RX7/RBCK1/TP53BP1/TYK2/MAP3K7/TBK1/TRPM7/TRAF3/MAVS/MFN2/PLCB1/MAPK14/MFN1/RIPK1/NLRX1/PLCB3/FADD/TRPM2/NLRP7/TAB1/TRAF2/DEFA3	1.25059930373446
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/1680	52/9376	1.3952380952381	ANGPTL4/SCARB1/LRP1/ABCA1/MYLIP/PLTP/LIPG/SOAT1/LCAT/APOE/STARD3NL/STARD3/VAPB	1.33526383526383
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1680	67/9376	1.33276474769012	ITPR2/MAPK3/CAMK2G/ATF4/EP300/RAF1/HRAS/RPS6KA1/CALM3/NRAS/RAPGEF3/PLCB1/GRIN2D/CACNA1C/PLCB3/CALML4	1.27711776969911
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	27/1680	122/9376	1.23512880562061	PIK3CB/VAV3/PIK3R2/MAPK3/AKT3/CBLB/VAV2/PPP2R3B/FOS/MAPK9/GRB2/PAK1/RAF1/HRAS/MAP2K7/AKT1/PAK2/PPP2R5E/DLG1/MAP3K7/SOS1/NRAS/MAP3K14/PIK3R3/AKT2/MAPK14/PLCG1	1.22131799221719
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/1680	112/9376	1.24574829931973	TGFB2/BIRC7/IL10RB/IL10RA/MAPK3/AKT3/TGFB1/LAMA5/ITGB1/LAMB1/MAPK9/LAMA4/GNAI1/JAK1/AKT1/XIAP/LAMC1/TYK2/MAP3K7/HLA-DQA1/AKT2/NOS2/MAPK14/JAK2/TAB1	1.22238499074384
NA	NA	hsa03272	Virion - Hepatitis viruses	12/1680	48/9376	1.3952380952381	CLDN19/SCARB1/HSPG2/CLDN7/DPP4/CD63/LAMP2/LAMP1/EGFR/CHMP1A/CLDN23/CLDN14	1.2826049071735
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/1680	133/9376	1.21689939133548	ITPR2/CACNA1A/CREB3L2/CREB5/GNG12/ATF6B/AKT3/CAMK2G/PPP2R3B/ATF4/FOS/MAOA/MAPK9/GNAI1/AKT1/PPP2R5E/GNAS/ADCY5/CALM3/AKT2/GSK3A/PLCB1/MAPK14/GNAL/CACNA1C/KCNJ6/KCNJ5/PLCB3/CALML4	1.17702429387616
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	24/1680	108/9376	1.24021164021164	DDX39B/NXF1/NUP50/ACIN1/XPOT/NUP58/UPF2/TNPO3/XPO7/POM121/NUP93/NUP155/RANGAP1/UPF1/NUP62/IPO9/NUP133/IPO4/AAAS/THOC6/NUP160/NUP107/NUP43/NCBP1	1.17306118122569
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	23/1680	103/9376	1.24623208506704	DDX39B/SYMPK/NXF1/CPSF1/PABPN1/PPP2R3B/PCF11/ACIN1/PAPOLA/UPF2/DAZAP1/PPP2R5E/NUDT21/UPF1/SMG7/MSI2/PABPC1L/FUS/CPSF2/PABPC3/SMG5/CPSF4/NCBP1	1.17398047675455
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1680	44/9376	1.3952380952381	CDK7/TAF5L/TAF9/TAF4B/TAF1/TAF3/GTF2H4/TAF4/TAF6/TBP/ERCC3	1.22773749785541
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1680	12/9376	1.86031746031746	NECTIN4/CD46/FCGR2B/CD209	1.39324151599763
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	38/1680	181/9376	1.17169166008945	MRC2/TGFB2/IL10RB/CEBPB/IL10RA/MAPK3/KSR1/AKT3/CAMK2G/TGFB1/CD14/EP300/MAPK9/LAMP2/JAK1/RAF1/AKT1/APAF1/MRC1/CALM3/PLK3/LAMP1/FCGR3A/RAB5C/ATP6V0A1/NFYA/HLA-DQA1/AKT2/NOS2/PIK3C3/MAPK14/NFYB/FCGR2B/CALML4/FADD/CD209/JAK2/TRADD	1.08973367086426
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1680	31/9376	1.44024577572965	SHMT1/GCSH/GLDC/HYI/AGXT/AMT/PCCA/MCEE	1.1470811448402
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/1680	157/9376	1.17306642402184	PPARG/PIK3CB/PRKAG2/PIK3R2/NDUFA6/CEBPA/XBP1/NDUFS1/AKT3/TGFB1/SREBF1/INSR/MLXIP/ITCH/NDUFS3/ATF4/FOS/NDUFA7/MAPK9/PRKAG1/RXRA/AKT1/CASP7/SDHA/PIK3R3/NDUFA13/PPARA/AKT2/GSK3A/MAPK14/COX4I2/PRKAB2/TRAF2	1.02171198646311
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1680	173/9376	1.16135425268373	PIK3CB/IFNAR2/TNFSF10/PIK3R2/MAPK3/IRF3/ADAR/AKT3/NXF1/STAT2/PABPN1/EP300/OAS3/JAK1/RAF1/AKT1/OAS1/APAF1/IFNAR1/TRIM25/TYK2/TBK1/TRAF3/PIK3R3/HLA-DQA1/MAVS/AKT2/BAK1/SLC25A4/NLRX1/FADD/JAK2/CXCL10/CPSF4/TLR7/TRADD	1.00079817870546
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	35/1680	168/9376	1.16269841269841	CSF2RB/PIK3CB/IFNAR2/IL10RB/CSF2RA/IL10RA/PIK3R2/IL2RB/IL13RA1/AKT3/STAT2/IL6ST/PDGFB/LIFR/EPOR/EP300/JAK1/SOCS7/GRB2/RAF1/HRAS/AKT1/IFNAR1/IL11/STAT6/TYK2/SOS1/PIK3R3/CSH1/EGFR/AKT2/MTOR/IL11RA/STAM2/JAK2	0.994175487764718
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1680	41/9376	1.36120789779326	PIPOX/SHMT1/GCSH/GLDC/MAOA/PHGDH/AGXT/AMT/GATM/PSAT1	1.08292842748219
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1680	13/9376	1.71721611721612	RAD50/POLM/DCLRE1C/XRCC4	1.20898790037078
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1680	71/9376	1.25767940979209	F11R/PLCG2/JAM2/TJP1/LYN/ADAM10/MAPK9/PAK1/GIT1/MAP3K14/EGFR/ATP6V0A1/MAPK14/PLCG1/ATP6V1C2/ATP6V1E2	1.0182594569909
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/1680	117/9376	1.19251119251119	MBD3/SMARCB1/MORF4L2/MBD2/SMARCA4/INO80D/SRCAP/PBRM1/EP400/BAZ2A/CHD4/TFPT/SMARCD2/SMARCC1/INO80B/SMARCC2/SMARCA1/HDAC1/MTA3/BICRA/MTA2/NFRKB/TRRAP/KAT5/RBBP7	0.978981810390512
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1680	32/9376	1.3952380952381	BIRC7/MAPK9/APAF1/CASP7/XIAP/BIRC6/BAK1/FADD	1.04634552548803
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/1680	37/9376	1.35752895752896	GFPT1/RIMKLB/AGXT/ADSL/GPT2/GFPT2/GPT/IL4I1/PPAT	1.01805126169997
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1680	18/9376	1.55026455026455	FASN/ACSL4/ACSL5/ACACA/HSD17B8	1.09175205181328
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	5/1680	18/9376	1.55026455026455	CD320/HCFC1/PRDX1/ABCD4/ZNF76	1.09175205181328
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1680	78/9376	1.21636141636142	ITGA5/SERPING1/MAPK3/C1QA/IRF3/ITGB1/CD14/C1QB/FOS/MAPK9/GNAI1/TICAM2/CASP7/CALM3/NOS2/MAPK14/CALML4	0.896478948562069
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1680	33/9376	1.35295815295815	IDH2/ACY1/AGXT/IDH1/GPT2/GPT/AADAT/DBT	0.948953131202649
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/1680	48/9376	1.27896825396825	PIK3CB/PIK3R2/AKT3/ATP1A1/AKT1/HK1/PIK3R3/AKT2/SLC37A4/PLCB1/PLCB3	0.905292419420651
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1680	14/9376	1.59455782312925	B3GNT7/B4GALT2/FUT8/B4GALT3	1.04011544854177
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1680	79/9376	1.20096443640747	SLC6A2/DNM2/AP2A2/CACNA1A/SLC1A3/SLC17A8/CLTB/SLC6A4/NSF/SLC6A11/CLTC/SLC1A6/ATP6V0A1/SYT1/STX1A/ATP6V1C2/ATP6V1E2	0.838048376686895
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	41/1680	205/9376	1.11619047619048	TGFB2/PIK3CB/PDK3/GFPT1/PIK3R2/NDUFA6/AGTR1/TBC1D4/NDUFS1/AKT3/CAMK2G/TGFB1/INSR/SMAD3/NDUFS3/NDUFA7/MAPK9/AKT1/GYS1/CPT1B/SP1/SDHA/MMP2/CPT2/PIK3R3/NDUFA13/SLC2A1/PPARA/AKT2/GFPT2/MT-ND2/PDK4/PTPA/PLCB1/MAPK14/SLC25A4/MT-ND5/COX4I2/AGER/MTOR/PLCB3	0.785863041899108
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1680	19/9376	1.46867167919799	GCSH/GLDC/AMT/LIPT2/DBT	0.955399360246651
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1680	49/9376	1.25286686103013	CREB3L2/CREB5/ATF6B/ATF4/MAOA/GNAI1/FOSB/GNAS/ADCY5/GRIN2D/GRIN3B	0.829137807193018
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1680	85/9376	1.1818487394958	IMPDH2/TYMP/ENTPD4/GMPR2/UCK2/AMPD2/AK6/ADA/CANT1/NME2/AMPD3/AK1/ADSL/GDA/CTPS2/CMPK2/NME6/ENTPD6	0.786857841921282
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1680	34/9376	1.31316526610644	PRKAG2/CSNK1E/NFIL3/PRKAG1/SKP1/CUL1/PRKAB2/CRY1	0.854674731145616
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1680	362/9376	1.07918968692449	FGFR1/SPP1/ITGA5/COL4A1/COL4A2/FLT1/FN1/PGF/CSF1R/CCNE1/PIK3CB/IFNAR2/EFNA1/PIK3R2/MAPK3/CREB3L2/CREB5/IL2RB/ERBB2/ERBB3/GNG12/ATF6B/AKT3/PKN1/LAMA5/YWHAE/INSR/PDGFB/ITGB1/LAMB1/PPP2R3B/ATF4/EPOR/FLT4/LAMA4/RXRA/SGK1/JAK1/GRB2/PHLPP1/RAF1/HRAS/AKT1/TSC1/PTK2/IFNAR1/GYS1/PPP2R5E/LPAR2/LAMC1/STK11/FGF18/RBL2/SOS1/NRAS/PIK3R3/LPAR6/CSH1/EGFR/AKT2/TEK/ITGA3/EFNA4/EIF4EBP1/TP53/MTOR/TCL1B/JAK2/FGFR3/ANGPT2	0.717913109614136
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/1680	235/9376	1.09244174265451	FGFR1/PPARG/MGLL/SMARCB1/PRKAG2/ACSL4/NDUFA6/CREB3L2/CREB5/NDUFS1/NDUFS3/SMARCA4/NDUFA7/PRKAG1/ADCY7/GRB2/ACSL5/HRAS/TSC1/RPS6KA1/KDM1A/CPT1B/KDM3A/SMARCD2/GNAS/SDHA/SMARCC1/ADCY5/CPT1A/SMARCC2/CPT2/SOS1/NRAS/NDUFA13/COX19/KDM3B/MT-ND2/FRS2/MAPK14/ADCY9/MT-ND5/COX4I2/MTOR/SLC25A20/PRKAB2/KLB	0.670521874033685
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	27/1680	134/9376	1.12452025586354	ADM/ITPR2/MAPK3/MYH10/AGTR1/MYH9/CALD1/PPP1R12C/ADCY7/RAF1/PPP1R12B/PLA2G10/GNA12/GNAS/ROCK2/PRKCE/ADCY5/CALM3/ACTG2/PLCB1/ADCY9/GNA11/CACNA1C/PLCB3/CALML4/EDN3/PLA2G4B	0.678292743669213
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1680	30/9376	1.30222222222222	SHMT1/FOLR2/FOLR1/ABCC1/ABCG2/ABCC3/ATIC	0.774607830873195
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1680	109/9376	1.12643075578855	IL1RAP/MAPK3/EBI3/IL1R1/IL2RB/GATA3/TGFB1/IL6ST/SMAD3/RXRB/FOS/MAPK9/RXRA/JAK1/SMAD4/STAT6/TYK2/HLA-DQA1/MAPK14/PLCG1/MTOR/JAK2	0.620303384995203
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1680	36/9376	1.24021164021164	GAA/UGP2/GYS1/HK1/PGM1/AGL/PYGB/GBE1	0.674651686731543
NA	NA	hsa04981	Folate transport and metabolism	7/1680	31/9376	1.26021505376344	SHMT1/FOLR2/FOLR1/ABCC1/SLCO2B1/ABCG2/ABCC3	0.678002602707365
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/1680	16/9376	1.3952380952381	MIF/MAOA/ALDH3B2/IL4I1	0.739245371686994
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1680	16/9376	1.3952380952381	HEXB/HEXA/ST8SIA1/NAGA	0.739245371686994
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1680	116/9376	1.10656814449918	GRK3/ITPR2/MAPK3/CACNA1A/SLC1A3/GNG12/SLC17A8/HOMER1/GNAI1/ADCY7/SHANK2/GNAS/ADCY5/SLC1A6/PLCB1/ADCY9/GRIN2D/CACNA1C/PLD2/GRIK2/PLCB3/PLA2G4B/GRIN3B	0.539583492715915
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1680	154/9376	1.08719851576994	TPM1/MAPK3/CREB3L2/CREB5/AGTR1/ATF6B/AKT3/CAMK2G/PPP2R3B/ATF4/SLC9A1/GNAI1/ADCY7/ATP1A1/AKT1/PPP2R5E/GNAS/ADCY5/CALM3/RAPGEF3/AKT2/RPS6KA5/PLCB1/MAPK14/ADCY9/SCN1B/CACNA1C/CACNB3/PLCB3/CALML4	0.509758696713664
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1680	32/9376	1.22083333333333	LDHA/ACACA/MLYCD/PCCA/MCEE/DBT/ACADS	0.584629804150691
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	32/1680	166/9376	1.0758462421113	ITPR2/MAPK3/CREB3L2/EDNRB/VASP/CREB5/AGTR1/ATF6B/AKT3/INSR/ATF4/GNAI1/ADCY7/ATP1A1/NFATC4/RAF1/AKT1/SRF/GNA12/ROCK2/PRKCE/ADCY5/CALM3/AKT2/PLCB1/ADCY9/SLC25A4/GNA11/CACNA1C/PLCB3/CALML4/MEF2B	0.460644665852924
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1680	43/9376	1.16810631229236	ACSL4/ACADVL/ACSL5/CPT1B/CPT1A/CPT2/ALDH1B1/ALDH3A2/ACADS	0.516196868611899
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	17/1680	86/9376	1.10321151716501	CREB3L2/CREB5/ATF6B/CAMK2G/ATF4/ADCY7/ATP1A1/GNAS/ADCY5/SLC2A1/KCNN2/PLCB1/ADCY9/GNA11/CACNA1C/PLCB3/STX1A	0.44923882246707
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1680	44/9376	1.14155844155844	CREB3L2/CREB5/NSF/DYNLL2/DYNC1LI2/GNAS/RAB5C/AQP3/ADCY9	0.439726354653581
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	30/1680	158/9376	1.05967450271248	CCNE1/TGFB2/CDK7/CDKN1C/TGFB1/YWHAE/SMAD3/EP300/SKP1/RB1/SMAD4/ATM/PPP2R5E/E2F4/PDS5B/PDS5A/MCM4/RBL2/HDAC1/CUL1/CDC14A/MAU2/E2F3/TP53/ZBTB17/DDX11/TFDP2/ORC2/ATR/TTK	0.353432717292884
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	50/1680	268/9376	1.04122245913291	SLC39A1/TUBB2A/SLC39A7/TUBB/ITPR2/NDUFA6/XBP1/NDUFS1/PSMC4/CAMK2G/PSMA2/NDUFS3/SLC39A14/ATF4/SLC39A4/MAOA/NDUFA7/MAPK9/PSMA6/DAXX/TUBA1C/GNAI1/APAF1/PINK1/DUSP1/TUBB6/GNAS/SDHA/ADCY5/CALM3/SLC39A11/UBE2L6/SLC11A2/GPR37/NDUFA13/MFN2/MT-ND2/UBA7/SLC39A9/MFN1/TP53/SLC39A13/SLC25A4/MT-ND5/GNAL/PLCG1/COX4I2/MAPT/CALML4/PSMA8	0.319887692905585
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	22/1680	115/9376	1.06766045548654	ITPR2/MAPK3/CACNA1A/GNG12/MAOA/GNAI1/RAF1/HRAS/SLC6A4/DUSP1/GNAS/ADCY5/NRAS/RAPGEF3/KCNN2/PLCB1/CYP2J2/CACNA1C/KCNJ6/KCNJ5/PLCB3/PLA2G4B	0.3410850188549
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	57/1680	308/9376	1.03283858998145	PPARG/TUBB2A/HIP1/TUBB/GPX3/NDUFA6/AP2A2/CREB3L2/SLC1A3/CREB5/NDUFS1/DNAH11/PSMC4/PSMA2/CLTB/WIPI1/NDUFS3/NDUFA7/GPX8/EP300/MAPK9/PSMA6/MAP3K10/TUBA1C/RCOR1/MAP2K7/TAF4B/APAF1/ATG13/SP1/TUBB6/CLTC/SDHA/TAF4/HDAC1/HTT/DNAH14/NDUFA13/ATG2B/MT-ND2/WIPI2/TFAM/PIK3C3/PLCB1/TP53/SLC25A4/MT-ND5/ULK2/COX4I2/MTOR/PLCB3/ULK1/STX1A/DNAH8/PSMA8/TBP/TRAF2	0.273786388622372
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1680	94/9376	1.06869300911854	CEBPB/MAPK3/SRSF1/FOS/MAPK9/MAPK6/FOSB/MAP3K7/TBK1/TRAF3/MAPK14/IL17D/MAPK15/IL17B/FADD/CXCL10/TRAF2/TRADD	0.31272560076839
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1680	149/9376	1.04876957494407	MGLL/ITPR2/MAPK3/NDUFA6/CACNA1A/GNG12/SLC17A8/NDUFS1/DAGLB/NDUFS3/GABRE/NDUFA7/MAPK9/GNAI1/ADCY7/ADCY5/NDUFA13/MT-ND2/PLCB1/MAPK14/ADCY9/MT-ND5/CACNA1C/KCNJ6/KCNJ5/FAAH/PLCB3/NAPEPLD	0.28036228695074
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1680	51/9376	1.09430438842204	LPCAT1/GDPD3/PLA2G7/PLPP2/PLA2G10/GDPD1/LPCAT4/PLD2/PLA2G4B/PAFAH2	0.315500695030141
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1680	35/9376	1.11619047619048	AKR1B1/PFKFB4/PFKL/GMPPA/PMM2/HK1/TIGAR	0.321747823156599
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	40/1680	217/9376	1.02874698266403	PIK3CB/PIK3R2/MAPK3/CACNA1A/CREB3L2/CREB5/ATF6B/AKT3/GSTA3/KLF5/RXRB/ATF4/FOS/ARNT/RXRA/GNAI1/ADCY7/GRB2/RAF1/HRAS/AKT1/RB1/RPS6KA1/KLF4/XIAP/GNAS/FGF18/ADCY5/SOS1/NRAS/PIK3R3/PPARA/EGFR/AKT2/EIF4EBP1/ADCY9/CACNA1C/MTOR/JAK2/GSTT1	0.200173164098328
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/1680	30/9376	1.11619047619048	B3GALT4/MPPE1/GPAA1/PIGN/DPM2/PIGW	0.297800909768476
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1680	52/9376	1.07326007326007	SCARB1/CYP11A1/CGA/INSR/ADCY7/GNAS/ADCY5/CYP2J2/ADCY9/PLA2G4B	0.247500247500247
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1680	63/9376	1.06303854875283	DDB1/CDK7/POLD4/ERCC5/GTF2H4/POLD1/CUL4B/RPA4/UVSSA/LIG1/POLE/ERCC3	0.234552155955403
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1680	69/9376	1.05148378191856	CTSB/ITPR2/KCNJ2/AGTR1/GNAI1/GNAS/ADCY5/CALM3/PLCB1/CACNA1C/PLCB3/CALML4/EDN3	0.200538554397851
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1680	36/9376	1.08518518518519	GALNT7/GALNT2/GALNT6/GALNT3/GALNT1/GALNT14/GALNT12	0.239248725911406
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/1680	36/9376	1.08518518518519	POLD4/POLD1/MCM4/RPA4/DNA2/LIG1/POLE	0.239248725911406
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1680	97/9376	1.03564064801178	MAPK3/GNG12/CAMK2G/FOS/GNAI1/ADCY7/GNAS/ADCY5/CALM3/RPS6KA5/PLCB1/ADCY9/GRIN2D/CACNA1C/KCNJ6/KCNJ5/PLCB3/CALML4	0.164849874563809
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1680	53/9376	1.05300988319856	DNM2/AP2A2/CLTB/ATP1A1/CLTC/GNAS/PTH1R/PLCB1/ADCY9/PLCB3	0.180810933980472
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1680	42/9376	1.06303854875283	AOC1/MAOA/KYAT1/ALDH1B1/IL4I1/AADAT/ALDH3A2/ALDH8A1	0.191295477552667
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1680	31/9376	1.08018433179724	ALDH3B2/CNDP2/ALDH1B1/MLYCD/ALDH3A2/ACADS	0.208924060574524
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/1680	59/9376	1.04051654560129	IDH2/GPX3/GSTA3/TXNDC12/GPX8/PRDX6/HPGDS/IDH1/GPX4/GGT7/GSTT1	0.145857282677932
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1680	48/9376	1.04642857142857	HIBADH/ALDH1B1/IL4I1/ALDH3A2/PCCA/MCEE/DBT/ACADS/AUH	0.150667443914959
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	43/1680	238/9376	1.00832332933173	RPS4Y1/PIK3CB/IFNAR2/F13A1/PLCG2/PIK3R2/MAPK3/C1QA/IRF3/RPS17/AGTR1/ADAR/RPS9/STAT2/IL6ST/C1QB/FOS/MAPK9/OAS3/JAK1/ISG15/OAS1/IFNAR1/RPL7A/C3AR1/NRP1/TYK2/MAP3K7/RPS18/RPL17/TBK1/TRAF3/PIK3R3/EGFR/RPS25/MAVS/RPS10/RPL36A/MAPK14/PLCG1/CXCL10/C9/TLR7	0.0607669907396439
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1680	37/9376	1.05585585585586	HBA2/HBA1/LAMA4/F2RL1/PLCB1/THOP1/PLCB3	0.159047605319578
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1680	93/9376	1.02017409114183	MAPK3/IL2RB/GATA3/FOS/MAPK9/MAML2/JAK1/MAML1/MAF/NOTCH3/STAT6/TYK2/HLA-DQA1/MAML3/MAPK14/PLCG1/JAK2	0.0913479966166394
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	42/1680	233/9376	1.00600858369099	ITGA5/COL4A1/FBLN1/COL4A2/TPM1/FN1/HSPG2/COL27A1/BGN/SYNE1/FMNL2/INF2/PKP2/MYH10/TNNI2/DAG1/MYH9/SYNE3/FHL2/FBN1/ITGB1/TLN1/SYNE2/CSRP1/MYOZ1/CSRP2/ATP1A1/PDLIM3/AMPD2/SUN2/SDC4/COL11A1/PDLIM5/TNNT3/AMPD3/DAAM2/ACTG2/TLN2/ITGA3/DIAPH2/DSP/LMNB2	0.0433923793720806
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/1680	368/9376	1.00093167701863	TUBB2A/TUBB/GPX3/NDUFA6/XBP1/NDUFS1/DNAH11/PSMC4/NXF1/PSMA2/WIPI1/NDUFS3/ATF4/NDUFA7/GPX8/NUP50/PSMA6/DAXX/TUBA1C/NUP58/ATXN2/APAF1/ATG13/SMCR8/SETX/PINK1/TUBB6/SDHA/TOMM40/RAB1A/POM121/NUP93/SRSF7/NUP155/TBK1/NUP62/DNAH14/NDUFA13/ATG2B/UBQLN2/MT-ND2/FUS/WIPI2/NOS2/UBQLN4/HDAC6/PIK3C3/MAPK14/TP53/GRIN2D/MT-ND5/ULK2/NUP133/COX4I2/SPG11/MTOR/NUP160/ALS2/ULK1/NUP107/VAPB/DNAH8/PSMA8/NUP43/NCBP1/TRAF2	0.00851888691435675
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1680	38/9376	1.0280701754386	PIK3CB/PIK3R2/MAPK3/INSR/SGK1/ATP1A1/PIK3R3	0.081006103034278
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1680	44/9376	1.01471861471861	POLD4/POLG2/POLG/LIG3/POLD1/PARG/LIG1/POLE	0.045720783052666
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1680	27/9376	1.03350970017637	FADS1/ELOVL2/FADS2/ACOT7/TECR	0.0814662252727607
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1680	254/9376	0.988751406074241	FGFR1/FLT1/ITPR2/P2RX4/PLCG2/CACNA1A/PTK2B/EDNRB/AGTR1/ERBB2/ERBB3/CHRM5/CAMK2G/PDGFB/PHKA2/FLT4/PTGER3/STIM2/ADCY7/NFATC4/P2RX7/GNAS/FGF18/CALM3/PHKB/EGFR/NOS2/PLCB1/PLCD3/MST1/ADCY9/SLC25A4/GRIN2D/GNAL/PLCG1/GNA11/TPCN1/CACNA1C/TACR3/PLCB3/CALML4/CASQ1/P2RX6/GRIN3B/FGFR3	-0.0849137093548109
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1680	154/9376	0.97847866419295	QPRT/DHRS3/NAPRT/PDXK/SHMT1/UGDH/RDH13/UGP2/RFK/CPOX/AK6/GMPPA/NMNAT2/PMM2/GUSB/NME2/AK1/ADSL/ALDH1B1/EARS2/NMNAT3/LIPT2/ALDH3A2/PSAT1/CTPS2/CMPK2/NME6	-0.125812784720819
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/1680	75/9376	0.967365079365079	CCNE1/SESN2/CCNG2/IGFBP3/SERPINE1/SHISA5/APAF1/ATM/SIAH1/PPP1R13L/TP53/ATR/PIDD1	-0.132573316209085
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1680	23/9376	0.970600414078675	ACY1/GPT2/NOS2/GPT	-0.0659534341696133
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1680	23/9376	0.970600414078675	POLD4/POLD1/RPA4/LIG1	-0.0659534341696133
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1680	128/9376	0.959226190476191	IMPDH2/ENTPD4/GMPR2/ADCY7/PDE10A/AMPD2/AK6/ADA/CANT1/ADCY5/NME2/AMPD3/AK1/ADSL/PGM1/GDA/ADCY9/PRUNE1/PPAT/NME6/ATIC/ENTPD6	-0.217005186418717
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/1680	82/9376	0.952845528455285	LGMN/HLA-G/CTSB/HSPA2/TAPBP/TAP1/TAP2/CANX/TAPBPL/PDIA3/CTSL/NFYA/HLA-DQA1/NFYB	-0.200371626612525
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1680	83/9376	0.94136546184739	GSDMD/IRF3/ADAR/CCL4/CCL4L2/GSDME/CASP7/TBK1/MAVS/POLR3A/RIPK1/POLR3B/FADD/CXCL10	-0.250681529513661
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1680	36/9376	0.93015873015873	AKR1B1/UGDH/UGP2/DCXR/GUSB/CRPPA	-0.19615423490873
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1680	89/9376	0.940609951845907	SPP1/ITGA5/COL4A1/COL4A2/FN1/HSPG2/DAG1/LAMA5/ITGB1/LAMB1/LAMA4/SDC4/LAMC1/ITGA3/GP1BB	-0.263013903884708
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1680	54/9376	0.93015873015873	LDHA/PHGDH/DNMT1/KYAT1/ADI1/MTAP/IL4I1/PSAT1/CDO1	-0.240470721924589
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1680	78/9376	0.93015873015873	TGFB2/MAPK3/TGFB1/ITGB1/FOS/JAK1/MAP3K7/FCGR3A/HLA-DQA1/NOS2/MAPK14/JAK2/TAB1	-0.289382595134031
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1680	73/9376	0.917416829745597	SMARCB1/NELFE/EP300/SUPT4H1/ELL/TNPO3/HGS/MLLT1/KAT2A/NELFB/SERINC5/MLLT3	-0.330939967532075
NA	NA	hsa04081	Hormone signaling	37/1680	219/9376	0.942900630571863	DIO2/POMC/PIK3CB/PIK3R2/AGTR1/GNG12/CGA/INSR/EPOR/GUCA2A/GNAI1/ADCY7/SLC16A2/SMAD4/GNA12/GNAS/THRB/STK11/PTH1R/ADCY5/RAPGEF3/BMPR1B/PIK3R3/ACVR1/CSH1/AMH/PLCB1/SST/ADCY9/GNA11/SSTR2/GIPR/MC1R/GUCA2B/PLCB3/JAK2/CRH	-0.399470315018639
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1680	38/9376	0.881203007518797	QPRT/NAPRT/NMNAT2/NMRK1/NMNAT3/SIRT5	-0.342829400341498
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1680	116/9376	0.914121510673235	IDH2/SHMT1/GCSH/GLDC/PHGDH/PFKL/ADPGK/AGXT/SDHA/H6PD/HK1/AMT/IDH1/GPT2/GPT/PCCA/PSAT1/MCEE/ACADS	-0.434826142820375
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1680	26/9376	0.858608058608059	SCARB1/ABCC1/ABCD4/SLC5A6	-0.337297619181385
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1680	75/9376	0.892952380952381	PYCR1/IDH2/SHMT1/PHGDH/PFKL/ALDH18A1/ACY1/IDH1/PYCR3/GPT2/GPT/PSAT1	-0.434861111144974
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1680	160/9376	0.906904761904762	CLDN19/PTPRF/ESAM/HLA-G/CLDN7/CD276/F11R/PVR/JAM2/CD274/ITGB1/SIGLEC1/SDC4/CD22/PDCD1LG2/CD99L2/GLG1/NLGN2/MAG/HLA-DQA1/PTPRS/L1CAM/CLDN23/CLDN14/LRRC4/CDH1	-0.55491181891791
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1680	59/9376	0.851331719128329	TYMP/ENTPD4/UCK2/CANT1/NME2/CTPS2/CMPK2/NME6/ENTPD6	-0.535197439626995
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/1680	90/9376	0.868148148148148	CA2/SCARB1/SLC9A1/RXRA/ADCY7/ATP1A1/GNAS/ADCY5/SLC2A1/SLC4A2/KCNN2/ADCY9/ABCG2/ABCC3	-0.587220080740612
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1680	28/9376	0.797278911564626	ELOVL2/ACOT7/TECR/PPT2	-0.501910571007303
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1680	28/9376	0.797278911564626	ST3GAL6/ST8SIA1/B4GALT2/B4GALT3	-0.501910571007303
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1680	28/9376	0.797278911564626	CA2/ATP6V0A1/ATP6V1C2/ATP6V1E2	-0.501910571007303
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/1680	133/9376	0.881203007518797	HLA-G/PIK3CB/IFNAR2/VAV3/TNFSF10/PLCG2/PIK3R2/MAPK3/RAC3/PTK2B/VAV2/GRB2/PAK1/RAF1/HRAS/IFNAR1/SOS1/NRAS/FCGR3A/PIK3R3/PLCG1	-0.644662695127286
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/1680	103/9376	0.866944059177069	COL4A1/COL4A2/COL27A1/MME/PRCP/DPP4/SLC36A1/COL21A1/ATP1A1/SLC36A4/COL11A1/COL16A1/COL23A1/MEP1A/COL26A1/CTRB2	-0.634381489316482
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1680	91/9376	0.858608058608059	GRK3/CACNA1A/GNG12/GABRE/GNAI1/ADCY7/PDE10A/GNAS/ADCY5/GRK5/GRK4/ADCY9/KCNJ6/KCNJ5	-0.633230973147461
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1680	67/9376	0.832977967306325	LDHA/GALM/PFKL/ADPGK/ALDH3B2/HK1/PGM1/ALDH1B1/MINPP1/ALDH3A2	-0.641013831438042
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/1680	110/9376	0.862510822510822	PIK3CB/PIK3R2/MAPK3/AKT3/MAPK9/STK10/GNAI1/ADCY7/RAF1/AKT1/RPS6KA1/ADCY5/PIK3R3/AKT2/MAPK14/SPDYE10/ADCY9	-0.677682792094167
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1680	43/9376	0.778737541528239	SCARB1/ABCA1/SLC27A1/AGPAT1/PLPP2/PLA2G10	-0.679421174892342
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1680	30/9376	0.744126984126984	IDH2/ACLY/SDHA/IDH1	-0.655812932440961
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1680	100/9376	0.837142857142857	CSF1R/IL10RB/CCL3/TNFSF10/IL10RA/IL2RB/CCR1/CCL4/CCL4L2/ACKR3/IL6ST/XCR1/CCL8/CCL13/CXCL10	-0.764952011340267
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1680	100/9376	0.837142857142857	ITGA5/CSF1R/MME/CSF2RA/IL1R1/CD14/EPOR/TFRC/IL11/CD22/IL1R2/HLA-DQA1/ITGA3/IL11RA/GP1BB	-0.764952011340267
Human Diseases	Substance dependence	hsa05034	Alcoholism	30/1680	191/9376	0.87658937920718	MAPK3/CREB3L2/CREB5/GNG12/ATF6B/HDAC5/ATF4/MAOA/GNAI1/GRB2/RAF1/HRAS/FOSB/GNAS/ADCY5/CALM3/SLC29A2/SLC29A1/SOS1/HDAC1/HDAC10/NRAS/CAMKK2/HDAC6/H2BC15/SLC29A3/GRIN2D/CALML4/CRH/GRIN3B	-0.805076944777005
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	48/1680	298/9376	0.898945349952061	IL1RAP/CSF1R/INHA/CSF2RB/TGFB2/GDF15/IFNAR2/IL10RB/TNFRSF25/CCL3/TNFSF10/CSF2RA/IL10RA/EBI3/IL1R1/IL2RB/CCR1/CCL4/IL13RA1/CCL4L2/TGFB1/BMPR2/ACKR3/IL6ST/RELT/LIFR/EPOR/CXCR6/INHBA/XCR1/RELL2/IFNAR1/IL11/IL1R2/RELL1/BMPR1B/ACVR1/CSH1/AMH/TNFRSF11A/IL17D/IL17B/IL11RA/CCL8/CCL13/CXCL10/GDF9/ACVR2B	-0.828279847436211
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	36/1680	227/9376	0.88508495909377	PIK3CB/HMOX1/PIK3R2/MAPK3/NDUFA6/NDUFS1/PRKD3/AKT3/GSTA3/NDUFS3/FOS/NDUFA7/MAPK9/ARNT/GRB2/RAF1/HRAS/MAP2K7/AKT1/PTK2/SDHA/SOS1/NRAS/MAP3K14/PIK3R3/NDUFA13/EGFR/CBR1/AKT2/MT-ND2/MAPK14/SLC25A4/MT-ND5/COX4I2/PLD2/GSTT1	-0.81886204255237
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1680	31/9376	0.720122887864823	PFKL/H6PD/PGM1/SHPK	-0.729233023691156
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1680	31/9376	0.720122887864823	UGDH/GUSB/ALDH1B1/ALDH3A2	-0.729233023691156
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1680	17/9376	0.656582633053221	AMACR/CH25H	-0.662124626054805
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1680	17/9376	0.656582633053221	GGT7/CDO1	-0.662124626054805
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1680	38/9376	0.734335839598997	TAP1/TAP2/ADA/DCLRE1C/AICDA	-0.766664903717274
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1680	39/9376	0.715506715506716	SHMT1/GCSH/GLDC/AMT/ATIC	-0.831779845442377
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1680	86/9376	0.778737541528239	ITGA5/TCF7L2/PKP2/DAG1/ITGB1/TCF7L1/TCF7/ITGA3/DSP/CACNA1C/CACNB3/CTNNA3	-0.963067776061379
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1680	26/9376	0.643956043956044	FADS2/PLA2G10/PLA2G4B	-0.849360844156233
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1680	93/9376	0.780133128520225	ITPR2/SLC9A1/ADCY7/ATP1A1/GNAS/ADCY5/CALM3/SLC4A2/PLCB1/ADCY9/PRH1/PLCB3/CALML4	-0.995554054497076
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1680	61/9376	0.731928181108509	HMOX1/SLC39A4/HMOX2/ATP1A1/TRPM7/SLC11A2/MT1H/ATP7B	-0.981369143215007
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	5/1680	41/9376	0.680603948896632	CACNA1A/SLC17A8/GABRE/GRIN2D/GRIN3B	-0.957573368352421
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/1680	194/9376	0.834266077565047	KIF12/TPM1/MYO7B/TUBB2A/KIF21A/TUBB/MYH10/TNNI2/MYO10/DNAH11/MYH9/MYO9B/DYNLRB1/TUBA1C/KIF26B/KIF3C/KIF2A/MYO19/DYNLL2/DYNC1LI2/TUBB6/KIF16B/TNNT3/MYO1C/DNAH14/ACTG2/MYO9A/DNAH8/MYO7A	-1.08981148208475
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1680	88/9376	0.761038961038961	SERPING1/F13A1/C1QA/TFPI/C1QB/SERPINE1/SERPINE2/PROCR/CD46/VSIG4/C3AR1/C9	-1.05224066141543
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1680	95/9376	0.763709273182957	FLT1/TGFB2/CCL3/TGFB1/FOS/IL11/CTSL/ATP6V0A1/HLA-DQA1/TEK/TNFRSF11A/ATP6V1C2/ATP6V1E2	-1.0814808756962
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1680	56/9376	0.697619047619048	EEF1G/CLK4/HSF1/CD14/APAF1/CASP7/RAB1A	-1.06034755043653
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1680	20/9376	0.558095238095238	SOAT1/LSS	-0.924285888039741
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1680	63/9376	0.708692365835223	HPGD/PLA2G10/PTGES/HPGDS/CBR1/GPX4/CYP2J2/PLA2G4B	-1.08388969910327
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1680	21/9376	0.531519274376417	ALDH1B1/ALDH3A2	-1.00412372544452
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	24/1680	168/9376	0.797278911564626	IFNAR2/TNFSF10/CAMK2G/STAT2/RNF31/MAPK9/JAK1/TICAM2/IFNAR1/XIAP/STAT6/RBCK1/TYK2/TRPM7/CHMP1A/RIPK1/SLC25A4/FADD/PYGB/USP21/JAK2/PLA2G4B/TRAF2/TRADD	-1.23873572970266
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1680	37/9376	0.603346203346203	MIF/MAOA/ALDH3B2/IL4I1	-1.12945787925101
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1680	30/9376	0.558095238095238	PLA2G10/CYP2J2/PLA2G4B	-1.13261985354568
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1680	46/9376	0.606625258799172	HMOX1/HMOX2/CPOX/GUSB/EARS2	-1.24954618735174
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1680	23/9376	0.485300207039337	CA2/ATP1A1	-1.15464955877225
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1680	102/9376	0.711297852474323	CA2/ITPR2/SLC9A1/ADCY7/ATP1A1/PLA2G10/GNAS/ADCY5/SLC4A2/PLCB1/ADCY9/PLCB3/CTRB2	-1.36969636772272
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1680	89/9376	0.689780631353665	CACNA1A/GNG12/GABRE/GNAI1/ADCY7/NSF/SLC6A11/ADCY5/ADCY9/CACNA1C/KCNJ6	-1.37383298623742
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/1680	195/9376	0.772747252747253	PIK3CB/GSDMD/PLCG2/PIK3R2/MAPK3/AKT3/HDAC5/RAF1/AKT1/MAP3K7/HDAC1/HDAC10/FCGR3A/PIK3R3/AKT2/HDAC6/H2BC15/PLCB1/MAPK14/SLC25A4/PLCG1/AGER/MTOR/PLCB3/FPR3/ELANE/TLR7	-1.49826696391544
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1680	15/9376	0.372063492063492	AK1	-1.13712442974709
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1680	105/9376	0.690975056689342	ITGA5/TPM1/TGFB2/DAG1/TGFB1/ITGB1/ADCY7/GNAS/ADCY5/ITGA3/ADCY9/CACNA1C/CACNB3	-1.48775919807785
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1680	99/9376	0.676479076479076	ITGA5/TPM1/TGFB2/PRKAG2/DAG1/TGFB1/ITGB1/PRKAG1/ITGA3/CACNA1C/CACNB3/PRKAB2	-1.51190304667809
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/1680	50/9376	0.558095238095238	LRP1/HBA2/TGFB2/HBA1/TGFB1	-1.46377298489052
NA	NA	hsa04082	Neuroactive ligand signaling	27/1680	199/9376	0.757214644651831	SLC6A2/POMC/P2RX4/SLC1A3/GNG12/SLC17A8/CHRM5/GABRE/GNAI1/ADCY7/SLC6A4/SLC6A11/GNAS/ADCY5/SLC1A6/PLCB1/ADCY9/GRIN2D/GNAL/GNA11/GRIK2/TACR3/PLCB3/P2RX6/P2RY1/GRIN3B/P2RY6	-1.61735892244828
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	39/1680	275/9376	0.79148051948052	TUBB2A/PIK3CB/TUBB/ITPR2/PIK3R2/MAPK3/C1QA/CSNK2B/NDUFA6/CREB3L2/CREB5/ATF6B/NDUFS1/PSMC4/PSMA2/NDUFS3/C1QB/ATF4/NDUFA7/MAPK9/PSMA6/TUBA1C/APAF1/LAMC1/TUBB6/SDHA/PIK3R3/NDUFA13/MT-ND2/CSNK2A2/MAPK14/SLC25A4/GRIN2D/MT-ND5/CACNA1C/COX4I2/PSMA8/C9/GRIN3B	-1.63974446493227
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/1680	66/9376	0.591919191919192	TGFB2/GATA3/TGFB1/SMAD3/MAF/STAT6/HLA-DQA1	-1.55435798058819
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1680	17/9376	0.328291316526611	KYAT1	-1.29508552469773
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1680	17/9376	0.328291316526611	CA2	-1.29508552469773
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	46/1680	323/9376	0.794810555801268	SOX4/ITGA5/TPM1/TIMP3/CCNE1/TGFB2/PIK3CB/EFNA1/HMOX1/PLCG2/PIK3R2/MAPK3/ERBB2/ERBB3/SLC7A1/BMPR2/HDAC5/RECK/PDGFB/DNMT1/EP300/CRKL/TRIM71/GRB2/ABCC1/RAF1/HRAS/ATM/NOTCH3/BMI1/PRKCE/SOS1/HDAC1/RDX/NRAS/PIK3R3/EGFR/RPS6KA5/EFNA4/BAK1/BMF/E2F3/TP53/PLCG1/MTOR/FGFR3	-1.75334656000732
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	17/1680	138/9376	0.687508626639061	CCNE1/ITPR2/MAPK3/CAMK2G/YWHAE/ADCY7/SKP1/RPS6KA1/PPP2R5E/ADCY5/CALM3/REC8/CUL1/MAPK14/SPDYE10/ADCY9/CALML4	-1.72781144525146
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1680	28/9376	0.398639455782313	AKR1B1/CBR1	-1.48888907641093
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1680	46/9376	0.485300207039337	PSMC4/PSMA2/PSMA6/PSMA8	-1.63493253776654
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1680	29/9376	0.384893267651888	CALM3/CALML4	-1.54996220249577
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1680	47/9376	0.474974670719352	LDHA/ACACA/ALDH1B1/ALDH3A2	-1.68585177665759
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1680	31/9376	0.360061443932412	BAG6/SEC61A1	-1.66739010795684
Human Diseases	Immune disease	hsa05310	Asthma	2/1680	32/9376	0.348809523809524	PRG2/HLA-DQA1	-1.723948802536
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1680	50/9376	0.446476190476191	TGFB1/MAP3K14/HLA-DQA1/AICDA	-1.83350185090166
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1680	82/9376	0.544483159117305	IMPDH2/GSTA3/TYMP/UCK2/GUSB/NME2/NME6/GSTT1	-1.93560965412395
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1680	23/9376	0.242650103519669	FNTB	-1.69899762107356
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1680	99/9376	0.563732563732564	C1QA/C1QB/KRT23/C3AR1/FCGR3A/HLA-DQA1/KRT15/FCGR2B/FPR3/DEFA3	-2.03879878581182
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1680	34/9376	0.328291316526611	POLR3A/POLR3B	-1.83319320687584
NA	NA	hsa04382	Cornified envelope formation	26/1680	217/9376	0.668685538731622	CLDN19/COL4A1/COL4A2/KRT7/PRSS8/PCSK6/CLDN7/PKP2/SLC27A1/TJP1/PADI1/LAMA5/PPP2R3B/KRT23/UGCG/TCHH/KAZN/SPTLC2/PPP2R5E/GBA2/SPRR2G/KRT15/CLDN23/DSP/CLDN14/S100A13	-2.30703391721875
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1680	26/9376	0.214652014652015	MAFA	-1.87348729410593
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1680	27/9376	0.206701940035273	ACADS	-1.92860569093094
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1680	39/9376	0.286202686202686	HLA-G/HLA-DQA1	-2.08694634182667
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1680	54/9376	0.31005291005291	HLA-G/CGA/HLA-DQA1	-2.37555925295199
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1680	44/9376	0.253679653679654	HLA-G/HLA-DQA1	-2.31831264655282
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1680	73/9376	0.382257012393999	GSTA3/MAOA/ALDH3B2/HPGDS/GSTT1	-2.47551460705273
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1680	45/9376	0.248042328042328	HLA-G/HLA-DQA1	-2.36234491032231
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1680	86/9376	0.38936877076412	CACNA1A/SCN9A/PLCB1/CACNA1C/PLCB3/P2RY1	-2.65783569429552
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1680	68/9376	0.328291316526611	DHRS3/RDH13/RDH10/CYP26A1	-2.59725733378056
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/1680	87/9376	0.384893267651888	TPM1/SLC9A1/ATP1A1/CACNA1C/COX4I2/CACNB3	-2.69298153025573
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1680	79/9376	0.353224834237493	GSTA3/ALDH3B2/HPGDS/CBR1/GSTT1	-2.69713829689574
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1680	70/9376	0.31891156462585	GSTA3/HPGDS/CBR1/GSTT1	-2.67226025045129
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/1680	70/9376	0.31891156462585	HLA-G/RAC3/DAG1/HLA-DQA1	-2.67226025045129
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/1680	138/9376	0.485300207039337	NDUFA6/NDUFS1/NDUFS3/NDUFA7/SDHA/NDUFA13/ATP6V0A1/MT-ND2/MT-ND5/COX4I2/ATP6V1C2/ATP6V1E2	-2.84585197850826
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/1680	243/9376	0.551205173427396	DDX39B/PRPF8/PUF60/SRSF1/PRPF31/SNRNP70/SRSF6/ACIN1/LSM2/DHX16/SF3B1/RBM25/SNRNP200/SRSF5/SRSF7/PRPF3/PRPF19/FUS/DDX23/DHX38/PRPF40B/SNRNP27/THOC6/NCBP1	-3.3117077128742
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	15/1680	183/9376	0.457455113192818	CSNK2B/NXF1/FBL/AK6/GNL3/RMRP/LSG1/UTP6/CSNK2A2/NOL6/DROSHA/EMG1/GNL3L/BMS1/WDR36	-3.46290310031927
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/1680	143/9376	0.39027639027639	ACTN4/C1QA/C1QB/ACTN1/FCGR3A/HLA-DQA1/H2BC15/TRIM21/ELANE/C9	-3.43271195559278
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1680	66/9376	0.169119769119769	CYP11A1/HSD17B8	-3.16477837773225
Genetic Information Processing	Translation	hsa03010	Ribosome	17/1680	222/9376	0.427370227370227	RPS4Y1/RPS17/RPS9/MRPS24/MRPS18B/MRPS12/MRPL38/RPL7A/MRPL45/MRPL46/RPS18/RPL17/RPS25/RPS10/RPL36A/MRPS28/MRPS5	-4.03415617563783
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	35/1680	370/9376	0.527927927927928	ADM/POMC/P2RX4/EDNRB/AGTR1/CHRM5/CGA/S1PR2/GABRE/PTGER3/CHRNE/KISS1R/P2RX7/C3AR1/LPAR2/THRB/PTH1R/LPAR6/CSH1/F2RL1/SST/GRIN2D/SSTR2/GIPR/GRIK2/CHRNA10/TACR3/MC1R/EDN3/P2RX6/CRH/FPR3/P2RY1/GRIN3B/P2RY6	-4.328634818316
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/1680	449/9376	0.136727118464312	GRK3/CAMK2G/NCALD/ANO2/CALM3/OR56A3/OR6C76/GNAL/CALML4/OR8A1/OR2C3	-8.75842975292128