category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04517	IgSF CAM signaling	35/385	299/9376	2.85071450288842	JAM3/PXN/PIK3R3/CASKIN2/MYH10/TUBB2B/AFDN/PLCG2/MTSS1/KDR/FGFR1/PTK2/BAIAP2/JAM2/ACTR3B/TRIO/NRP1/PARD3/UNC5B/ABL1/MAGI1/SPTBN1/NECTIN2/TUBB2A/MPP3/GIT1/SORBS1/IL1RAP/VAV2/TUBA1B/PAK2/SPTAN1/ERC1/RAPGEF2/PLCG1	6.73001231356298
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/385	212/9376	3.10159274687577	FLT1/ID1/VEGFC/RAPGEF5/KIT/PIK3R3/RAPGEF1/AFDN/KDR/TEK/FGFR1/CSF1R/PARD3/MAGI1/MAGI3/MRAS/DOCK4/KRAS/PLCB1/TLN1/SIPA1L2/VAV2/IGF1R/RAPGEF2/ARAP3/PLCB4/PLCG1	6.40451069536472
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/385	238/9376	2.86508785332315	FLT1/NTRK2/VEGFC/IGF2/RAPGEF5/RASGRF2/KIT/PIK3R3/GNGT1/AFDN/PLCG2/KDR/TEK/FGFR1/RASA4B/CSF1R/ABL1/GNB4/PLAAT3/MRAS/KRAS/KSR1/NF1/PLD1/IGF1R/SOS1/PAK2/PLCG1	6.03078990896097
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/385	203/9376	2.99916831936536	SPP1/FLT1/FN1/VEGFC/PXN/COL6A2/PIK3R3/RAPGEF1/KDR/PTK2/COL4A1/LAMA2/DOCK1/ROCK2/ITGA2/PARVB/TLN1/COL9A3/PIP5K1C/COL4A2/VAV2/PARVA/IGF1R/SOS1/PAK2	5.95872972572753
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/385	93/9376	4.1898058930317	CDH5/HEG1/AFDN/FGFR1/BAIAP2/ARHGAP29/RASIP1/PARD3/WASF2/NECTIN2/RADIL/ROCK2/SORBS1/CTNNA2/IGF1R/PTPRM	6.39695888242612
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/385	300/9376	2.43532467532468	FLT1/NTRK2/VEGFC/IGF2/RASGRF2/KIT/MEF2C/MECOM/KDR/RPS6KA2/DUSP6/TEK/FGFR1/CSF1R/MAP3K6/CD14/HSPA6/DUSP9/MRAS/KRAS/MAP4K3/IL1RAP/NF1/MAP3K11/STMN1/TAOK1/IGF1R/SOS1/PAK2/RAPGEF2	5.22848105767067
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/385	98/9376	3.72753776835409	FCGR2B/FCGR2A/PLPP3/PIK3R3/PLCG2/ACTR3B/WASF2/DOCK1/LIMK2/PIP5K1C/ASAP2/MARCKSL1/PLD1/VAV2/PLCG1	5.61653708599858
NA	NA	hsa04518	Integrin signaling	19/385	154/9376	3.0046213526733	SPP1/FLT1/FN1/VEGFC/PXN/COL6A2/PIK3R3/KDR/PTK2/COL4A1/FERMT2/LAMA2/ITGA2/PARVB/TLN1/COL9A3/COL4A2/PARVA/IGF1R	5.19029637617623
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	21/385	184/9376	2.77944664031621	EFNB2/PIK3R3/SEMA3G/PLCG2/PTK2/EPHB4/BMPR2/SEMA4C/NRP1/PARD3/UNC5B/TRPC1/ABL1/ABLIM3/KRAS/ROCK2/LIMK2/ARHGEF12/PAK2/RGS3/PLCG1	5.04429964899866
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/385	204/9376	2.62633053221289	FN1/IGF2/PXN/PIK3R3/TIMP3/PLCG2/KDR/FGFR1/PTK2/ITPR2/MRAS/KRAS/ROCK2/CTSL/ITGA2/ARHGEF12/SDC2/VAV2/IGF1R/SOS1/CBL/PLCG1	4.85963756153144
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/385	362/9376	2.15277319365717	SPP1/FLT1/NTRK2/FN1/CSH1/VEGFC/IGF2/KIT/COL6A2/PIK3R3/GNGT1/PPP2R2A/KDR/TEK/FGFR1/PTK2/COL4A1/CSF1R/LAMA2/MAGI1/GNB4/CCNE1/KRAS/ITGA2/JAK2/COL9A3/YWHAH/COL4A2/DDIT4/IGF1R/SOS1/RPTOR	4.62861844260578
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/385	138/9376	3.0000376435159	FN1/FCGR2A/PXN/PIK3R3/RPS6KA2/PTK2/BAIAP2/ACTR3B/WASF2/DOCK1/ROCK2/ARHGEF7/GIT2/ARHGEF12/PIP5K1C/VAV2/PLCG1	4.89779651811447
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/385	65/9376	4.12131868131868	SPP1/GPER1/PIK3R3/KCNJ6/CGA/ITPR2/TRPC1/GNA11/KRAS/PLCB1/PLCB4	5.22526873138022
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/385	232/9376	2.30935960591133	FN1/PXN/PIK3R3/MYH10/FGFR1/PTK2/BAIAP2/ACTR3B/WASF2/DOCK1/MRAS/KRAS/ROCK2/GIT1/ARHGEF7/ITGA2/LIMK2/ARHGEF12/PIP5K1C/VAV2/SOS1/PAK2	4.17875420445907
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/385	52/9376	4.21498501498501	SCARB1/PLTP/ANGPTL4/CETP/CD36/APOE/ABCA1/APOA1/VAPB	4.81051415094527
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/385	76/9376	3.52481203007519	PLTP/FABP4/PPARG/ANGPTL4/CD36/SCD/SORBS1/ME3/FABP5/APOA1/NR1H3	4.57305449625844
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/385	116/9376	2.93918495297806	JAM3/PXN/PIK3R3/PECAM1/CDH5/AFDN/PLCG2/PTK2/JAM2/CLDN5/ROCK2/VAV2/CTNNA2/PLCG1	4.34865283385923
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	22/385	250/9376	2.14308571428571	GRK5/ACTR3B/AGAP1/PARD3/PSD3/FOLR2/HLA-G/HSPA6/IQSEC1/TFRC/GIT1/GIT2/PIP5K1C/ASAP2/MVB12B/PLD1/IGF1R/DAB2/EPS15/CBL/SNX32/ARAP3	3.79071010895939
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/385	157/9376	2.48185954173215	SLC2A1/PPARG/C1QA/PECAM1/MERTK/CD24/C1QB/C1QC/PTK2/CD36/ABCA1/XKR6/DOCK1/JAK2/NR1H3/PROS1	3.87460079971043
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/385	193/9376	2.27128726196084	PXN/PIK3R3/GNGT1/PLCG2/GRK5/PREX1/PTK2/PARD3/GNB4/KRAS/PLCB1/ROCK2/JAK2/CCL3/VAV2/SOS1/PLCB4/PLCG1	3.69268329663479
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/385	78/9376	3.12221112221112	FN1/PXN/PIK3R3/PTK2/ACTR3B/WASF2/DOCK1/SEPTIN11/CTNNA2/CBL	3.89451266782993
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/385	216/9376	2.14218374218374	PPARG/PIK3R3/PTK2/CD36/ABCA1/ERO1A/CD14/HSPA6/KRAS/PLCB1/TNFRSF10A/ROCK2/JAK2/APOA1/CCL3/VAV2/MIB1/PLCB4/PLCG1	3.51420519965223
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/385	93/9376	2.88049155145929	FN1/PIK3R3/PTK2/COL4A1/LAMA2/CCNE1/ITGA2/RARB/BIRC7/COL4A2/RB1	3.77120976536965
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/385	200/9376	2.19179220779221	FCGR2A/MYH10/TUBB2B/MYO1E/BAIAP2L1/BAIAP2/ACTR3B/WASF2/CLDN5/ABL1/MYO1C/TUBB2A/TNFRSF10A/ROCK2/ARHGEF12/RIPK1/TUBA1B/PAK2	3.52533863940215
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/385	68/9376	3.22322383498854	KIT/PIK3R3/DUSP6/CSF1R/PER2/CD14/KRAS/RUNX1T1/SOS1	3.80733825922437
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/385	110/9376	2.65671782762692	ID1/SMAD6/LRRC32/LTBP1/IGSF1/BMPR2/ID2/SMAD7/SMAD9/TFRC/SKI/ACVR2B	3.61668549505092
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/385	115/9376	2.54120835686053	PDE4D/LRP5/MEF2C/MEF2A/FGFR1/ITPR2/GNA11/PLCB1/KL/PLD1/PDE4B/PLCB4	3.44106865350306
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/385	86/9376	2.83177287828451	NRG3/PIK3R3/PLCG2/PTK2/ABL1/KRAS/SOS1/CBL/PAK2/PLCG1	3.53122180206403
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/385	101/9376	2.65233380480905	FN1/VEGFC/PIK3R3/PLCG2/COL4A1/KRAS/PLCB1/JAK2/COL4A2/PLCB4/PLCG1	3.45472529607554
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/385	89/9376	2.73631985991537	TUBB2B/GJA1/ITPR2/TUBB2A/GNA11/KRAS/PLCB1/TUBA1B/SOS1/PLCB4	3.40564219015006
NA	NA	hsa04081	Hormone signaling	18/385	219/9376	2.00163671944494	GPER1/CSH1/IGF2/PIK3R3/ADRB2/GNGT1/CGA/RAMP2/GNB4/VIPR1/GNA11/NPR1/PLCB1/SMAD9/JAK2/DIO2/IGF1R/PLCB4	3.10361392391962
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/385	122/9376	2.39540131999148	CSH1/PIK3R3/PLCG2/PTK2/ITPR2/GNA11/KRAS/PLCB1/JAK2/SOS1/PLCB4/PLCG1	3.21015720892512
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/385	155/9376	2.19964809384164	FCGR2B/SCARB1/FCGR2C/FCGR2A/TUBB2B/CD36/CD14/HLA-G/TUBB2A/TFRC/MRC1/CTSL/ITGA2/TUBA1B	3.11632476147791
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/385	80/9376	2.73974025974026	PIK3R3/PLCG2/KDR/KRAS/JAK2/NF1/IGF1R/SOS1/PLCG1	3.23365254890717
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	13/385	144/9376	2.198556998557	ID1/PIK3R3/FGFR1/BMPR2/ID2/KLF4/LIFR/DUSP9/KRAS/SMAD9/JAK2/ACVR2B/IGF1R	2.99919044921893
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/385	99/9376	2.45992391446937	GPER1/PIK3R3/JAG2/NOTCH1/PTK2/DLL4/KRAS/RB1/IGF1R/SOS1	3.0217327097144
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/385	233/9376	1.88136670196756	FN1/COL6A2/MYH10/FBLN2/COL4A1/FMNL2/LAMA2/SPTBN1/FMNL3/ITGA2/CSRP2/TLN1/COL9A3/SDC2/PDLIM4/COL4A2/SPTAN1/TMOD2	2.81904652595106
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/385	115/9376	2.32944099378882	PIK3R3/GNGT1/KCNJ6/ITPR2/KCNQ1/GNB4/GNA11/KRAS/PLCB1/JAK2/PLCB4	2.96825390937238
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	19/385	253/9376	1.82889995380114	PXN/PIK3R3/PLCG2/PTK2/ACTR3B/WASF2/ITPR2/CD14/DOCK1/NOD1/SEPTIN11/PLCB1/TECPR1/ROCK2/TLN1/RIPK1/PLCB4/PLCG1/RPTOR	2.76570301226798
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/385	149/9376	2.12477991806851	PLPP3/KIT/PIK3R3/PLCG2/DGKH/MRAS/KRAS/PLCB1/PIP5K1C/PLD1/SOS1/PLCB4/PLCG1	2.86379833221387
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/385	201/9376	1.93856690573108	FLT1/PPARG/MEF2C/DUSP6/PTK2/CSF1R/ID2/PER2/CD14/HPGD/NSD2/HOXA11/RUNX1T1/FUT8/IGF1R/FLI1	2.7833782748383
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/385	103/9376	2.36439288866473	FN1/PIK3R3/PTK2/COL4A1/LAMA2/CD14/GNA11/PLCB1/COL4A2/PLCB4	2.88111062293422
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/385	59/9376	2.88936825885978	FABP4/PIK3R3/ADRB2/MGLL/CGA/PLAAT3/NPR1	3.01242731710295
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/385	333/9376	1.68205608205608	SPP1/FN1/PXN/COL6A2/PIK3R3/PPP2R2A/NOTCH1/PTK2/COL4A1/LFNG/PARD3/LAMA2/MAGI1/HLA-G/CCNE1/KRAS/ITGA2/COL9A3/COL4A2/RB1/SOS1/UBR4/MAML2	2.62239399318367
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/385	170/9376	2.0055614973262	JAM3/MYH10/CGNL1/AFDN/PPP2R2A/JAM2/ACTR3B/PARD3/CLDN5/MAGI1/ROCK2/AMOTL1/TUBA1B/RAPGEF2	2.73784977921268
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/385	89/9376	2.46268787392383	SPP1/FN1/COL6A2/COL4A1/CD36/LAMA2/ITGA2/COL9A3/COL4A2	2.86893656489001
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/385	60/9376	2.84121212121212	PXN/PIK3R3/PLCG2/KDR/PTK2/KRAS/PLCG1	2.96057941189216
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/385	227/9376	1.82381143085989	PXN/PIK3R3/GNGT1/PTK2/ITPR2/HLA-G/GNB4/GNA11/KRAS/PLCB1/ROCK2/ARHGEF12/RIPK1/CCL3/RB1/SOS1/PLCB4	2.59995560703927
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/385	140/9376	2.08742115027829	SPP1/GNGT1/MEF2C/APLNR/MEF2A/KLF2/ITPR2/GNB4/MRAS/KRAS/PLCB1/PLCB4	2.68245123521239
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/385	62/9376	2.74956011730205	NRARP/JAG2/NOTCH1/DLL4/LFNG/NCOR2/MAML2	2.86001691777248
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/385	142/9376	2.05802085238705	PIK3R3/PECAM1/CDH5/MEF2C/KDR/MEF2A/PTK2/BMPR2/KLF2/CTSL/SDC2/ACVR2B	2.62878742392846
NA	NA	hsa04519	Cadherin signaling	26/385	404/9376	1.56728815738717	CDH5/LRP5/AFDN/MYO1E/PRICKLE2/KDR/FGFR1/PTK2/GJA1/WWTR1/ACTR3B/MYO1C/KRT7/MRAS/KRAS/TMC6/ROCK2/AMOTL1/TEAD1/YWHAH/LIMA1/VAV2/TAOK1/CTNNA2/IGF1R/ATN1	2.41191374022575
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/385	99/9376	2.21393152302243	PLPP3/PIK3R3/WASF2/DGKH/KRAS/PIP5K1C/PLD1/SOS1/PLCG1	2.51258065856367
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/385	15/9376	4.87064935064935	ST3GAL5/ST6GALNAC3/ST3GAL2	3.104419055704
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/385	70/9376	2.43532467532468	SLC2A1/EPAS1/PIK3R3/RAPGEF1/KRAS/SOS1/PAK2	2.49419067442865
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/385	103/9376	2.12795359979826	C1QA/PIK3R3/C1QB/PPP2R2A/C1QC/GNA11/PLCB1/CCL3/PLCB4	2.38183526574669
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/385	122/9376	1.99616776665957	SLC2A1/PIK3R3/PLCG2/NOTCH1/DIO3/KRAS/PLCB1/DIO2/PLCB4/PLCG1	2.291709984523
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/385	29/9376	3.35906851768921	TPTEP2-CSNK1E/RASSF4/WWTR1/TEAD1	2.63278525255941
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/385	73/9376	2.33524283935243	PIK3R3/PLCG2/KRAS/RARB/RB1/SOS1/PLCG1	2.36985722023909
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/385	43/9376	2.83177287828451	SCARB1/PLPP3/CD36/ABCA1/APOA1	2.49119213122846
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/385	91/9376	2.1409447695162	PDE10A/PDE4D/GNGT1/KCNJ6/GRK5/PDE8A/GNB4/PDE4B	2.26311367031413
Organismal Systems	Immune system	hsa04611	Platelet activation	10/385	126/9376	1.93279736136879	FCGR2A/PIK3R3/PLCG2/ITPR2/PLCB1/ROCK2/ITGA2/ARHGEF12/TLN1/PLCB4	2.18129156130857
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/385	60/9376	2.43532467532468	ITPR2/GNA11/KRAS/PLCB1/IGF1R/PLCB4	2.30793216826616
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/385	76/9376	2.24306220095694	PIK3R3/PLCG2/KRAS/RB1/IGF1R/SOS1/PLCG1	2.25149085139845
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/385	110/9376	1.99253837072019	SLC2A1/FLT1/EPAS1/PIK3R3/PLCG2/TEK/TFRC/IGF1R/PLCG1	2.16675348620294
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/385	93/9376	2.09490294651585	CGA/ITPR2/GNA11/KRAS/PLCB1/PLD1/SOS1/PLCB4	2.19576029513577
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/385	77/9376	2.21393152302243	PIK3R3/MECOM/ABL1/KRAS/RB1/SOS1/CBL	2.2132650805147
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/385	148/9376	1.81003861003861	KIT/PIK3R3/LRP5/JAG2/NOTCH1/FGFR1/DLL4/KRAS/RB1/IGF1R/SOS1	2.0553926002853
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/385	130/9376	1.87332667332667	VEGFC/PIK3R3/GNGT1/COL4A1/GNB4/KRAS/PLCB1/COL4A2/SOS1/PLCB4	2.07483449828394
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/385	133/9376	1.83107118445464	PIK3R3/PLCG2/ULBP1/HLA-G/KRAS/TNFRSF10A/ULBP2/VAV2/SOS1/PLCG1	1.99742082025494
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/385	98/9376	1.98802014312218	PIK3R3/PLCG2/ITPR2/DGKH/PLCB1/PIP5K1C/PLCB4/PLCG1	2.0345279320946
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/385	134/9376	1.81740647412289	MYH10/PPP1R14A/ITPR2/RAMP2/GNA11/NPR1/PLCB1/ROCK2/ARHGEF12/PLCB4	1.9720571398288
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/385	65/9376	2.24799200799201	SCARB1/PDE8A/ITPR2/GNA11/PLCB1/PLCB4	2.08921109382463
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/385	214/9376	1.59320305862362	PXN/PIK3R3/GNGT1/PLCG2/PTK2/ITPR2/HLA-G/GNB4/GNA11/KRAS/LIMK2/RIPK1/PAK2/PLCG1	1.81646539525973
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/385	120/9376	1.82649350649351	NTRK2/PIK3R3/RAPGEF1/PLCG2/RPS6KA2/ABL1/KRAS/SOS1/PLCG1	1.88551677239788
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/385	157/9376	1.70627843494086	ID1/PPP2R2A/TPTEP2-CSNK1E/BMPR2/WWTR1/ID2/PARD3/SMAD7/TEAD1/YWHAH/CTNNA2	1.84669795737949
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/385	36/9376	2.70591630591631	GALNT18/ST6GALNAC3/GALNT2/ST3GAL2	2.12201054041608
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/385	52/9376	2.34165834165834	SCARB1/CYP1B1/HSD17B2/CGA/IGF1R	2.00749502974318
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/385	178/9376	1.64179191594922	LRP5/PRICKLE2/TPTEP2-CSNK1E/NOTUM/RSPO3/SOX17/CCN4/RUVBL1/PLCB1/ROCK2/CCDC88C/PLCB4	1.78883195791156
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/385	69/9376	2.11767363071711	PIK3R3/PLCG2/KRAS/VAV2/SOS1/PLCG1	1.92817610822327
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/385	69/9376	2.11767363071711	AQP1/ADRB2/ITPR2/NPR1/PLCB1/PLCB4	1.92817610822327
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/385	88/9376	1.93719008264463	F13A1/C1QA/C1QB/C1QC/VSIG4/CD46/PROS1	1.82776316647608
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/385	106/9376	1.83798088703749	PIK3R3/FGFR1/FOLR2/CCNE1/KRAS/RB1/IGF1R/SOS1	1.79539157495289
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/385	71/9376	2.05802085238705	JAM3/PLCG2/JAM2/NOD1/GIT1/PLCG1	1.8517280997312
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/385	125/9376	1.75343376623377	PIK3R3/SPTLC2/PPP2R2A/ACER2/KRAS/PLCB1/ROCK2/PLD1/PLCB4	1.75476009676818
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/385	323/9376	1.43254392666157	PIK3R3/TIMP3/ZFPM2/PLCG2/CYP1B1/NOTCH1/IGF2BP1/BMPR2/ABL1/DICER1/CCNE1/KRAS/FSCN1/STMN1/DDIT4/ST14/SOS1/PLCG1/RPTOR	1.63699451249597
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/385	91/9376	1.87332667332667	FCGR2B/PIK3R3/PLCG2/KRAS/VAV2/SOS1/LILRB5	1.73228151428718
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/385	12/9376	4.05887445887446	FCGR2B/CD46	2.19398461508886
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/385	115/9376	1.69413890457369	GNGT1/KCNJ6/ITPR2/TRPC1/GNB4/KRAS/PLCB1/PLCB4	1.54980967698037
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/385	97/9376	1.75745079662605	GNGT1/KCNJ6/PER2/GNB4/RASD1/PLCB1/PLCB4	1.5516783855611
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/385	116/9376	1.6795342588446	GNGT1/GLUL/ITPR2/TRPC1/GNB4/PLCB1/PLD1/PLCB4	1.52386629026327
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/385	155/9376	1.57117720988689	SCARB1/PDE8A/ITPR2/KMT2D/RASD1/CCNE1/GNA11/PLCB1/RB1/PLCB4	1.48374651824966
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	10/385	156/9376	1.56110556110556	SCARB1/PIK3R3/PPP2R2A/CLDN5/KRAS/RIPK1/YWHAH/RB1/SOS1/NR1H3	1.46235702509091
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/385	62/9376	1.96397151235861	PIK3R3/HSPA6/KRAS/IGF1R/RPTOR	1.57581028873006
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/385	137/9376	1.59984832685563	PIK3R3/DAB2IP/ITPR2/KRAS/TNFRSF10A/CTSL/RIPK1/TUBA1B/SPTAN1	1.46352874225632
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/385	14/9376	3.47903525046382	FUT8/ST3GAL2	1.92076576224857
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/385	99/9376	1.72194674012856	PIK3R3/PLCG2/ITPR2/PLCB1/IL1RAP/PLCB4/PLCG1	1.49427655626222
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/385	138/9376	1.58825522303783	PIK3R3/RAPGEF1/PHKA2/PHKB/KRAS/SORBS1/SOS1/CBL/RPTOR	1.44055007789379
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/385	63/9376	1.93279736136879	MECOM/PLOD2/KMT2D/NSD2/NSD1	1.53718021588064
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/385	100/9376	1.70472727272727	KIT/CD24/CD36/CSF1R/CD14/TFRC/ITGA2	1.46606326909151
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/385	139/9376	1.57682892646921	GPER1/PIK3R3/KCNJ6/ITPR2/HSPA6/KRAS/PLCB1/SOS1/PLCB4	1.41775426824338
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/385	160/9376	1.52207792207792	JAM3/PECAM1/CDH5/JAM2/SIGLEC1/CLDN5/HLA-G/NECTIN2/SDC2/PTPRM	1.37827567152844
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/385	142/9376	1.54351563929029	FCGR2B/FCGR2C/FCGR2A/PPARG/PIK3R3/PLCG2/CSF1R/ITPR2/LILRB5	1.3504337594587
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/385	31/9376	2.35676581483033	GLUL/PCCA/AFMID	1.56569833853289
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/385	226/9376	1.40085047695667	PDE10A/PIK3R3/PDE4D/ADRB2/AFDN/GLI3/CGA/NPR1/ROCK2/PLD1/VAV2/PDE4B/ARAP3	1.26222878893113
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/385	16/9376	3.04415584415584	FUT9/ST3GAL2	1.69335523193629
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/385	67/9376	1.81740647412289	RPS6KA2/ITPR2/KRAS/PLCB1/PLCB4	1.38942773399755
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/385	105/9376	1.62354978354978	PIK3R3/PLCG2/ITPR2/MRAS/KRAS/ARHGEF12/KSR1	1.32958006809707
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/385	49/9376	1.98802014312218	GALNT18/LFNG/GALNT2/FUT11	1.43484455685638
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/385	166/9376	1.4670630574245	ADRB2/MEF2C/MEF2A/ITPR2/GTF2I/GNA11/NPR1/PLCB1/ROCK2/PLCB4	1.25635320200503
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/385	17/9376	2.86508785332315	GLUL/CA4	1.59265252641456
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/385	17/9376	2.86508785332315	MYH10/TFRC	1.59265252641456
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/385	128/9376	1.52207792207792	PDE10A/PDE4D/PDE9A/PDE8A/ADSS1/NPR1/IMPDH1/PDE4B	1.23063257382436
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/385	51/9376	1.9100585688821	PLPP3/PEDS1/PLAAT3/PLD1	1.34847225482494
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/385	51/9376	1.9100585688821	PLCG2/ERO1A/KCNQ1/PLCG1	1.34847225482494
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	14/385	254/9376	1.34230493915533	FLT1/NTRK2/VEGFC/ADRB2/PHKA2/PLCG2/KDR/FGFR1/ITPR2/PHKB/GNA11/PLCB1/PLCB4/PLCG1	1.14445044971744
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/385	34/9376	2.14881588999236	NPAS2/TPTEP2-CSNK1E/PER2	1.38861536084045
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/385	90/9376	1.62354978354978	PPARG/PIK3R3/KRAS/KL/IGF1R/RPTOR	1.22995734965376
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/385	71/9376	1.71501737698921	PIK3R3/CGA/KRAS/JAK2/SOS1	1.25140989970078
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/385	71/9376	1.71501737698921	SLC2A1/KIT/PIK3R3/FGFR1/KRAS	1.25140989970078
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/385	194/9376	1.38085419734904	DYNLT5/MYH10/TUBB2B/DNAH8/MYO1E/KIF26A/MYO1C/TUBB2A/MYO15B/TUBA1B/MYO9A	1.10918240347739
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/385	73/9376	1.66803059953745	PIK3R3/FGFR1/KRAS/RB1/IGF1R	1.18565484344576
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/385	93/9376	1.57117720988689	JAG2/NOTCH1/DLL4/JAK2/PLCG1/MAML2	1.14546064831318
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/385	196/9376	1.3667638483965	PIK3R3/GNGT1/PLCG2/PREX1/ITPR2/HLA-G/GNB4/KRAS/JAK2/RB1/PLCG1	1.07375505218052
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/385	55/9376	1.77114521841795	PLPP3/SPTLC2/PSAP/ACER2	1.18685664292925
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/385	37/9376	1.97458757458757	GLUL/ADSS1/NAT8L	1.22908961316814
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/385	37/9376	1.97458757458757	PLCB1/APOA1/PLCB4	1.22908961316814
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/385	56/9376	1.73951762523191	MGAT4A/MGAT5/FUT8/TUSC3	1.1485412316848
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/385	158/9376	1.38721025809633	PIK3R3/LRP5/RPS6KA2/KRAS/GRB10/DDIT4/IGF1R/SOS1/RPTOR	1.01570841365435
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/385	21/9376	2.31935683364255	CHSY1/CHST3	1.25245469879083
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/385	98/9376	1.49101510734164	SCARB1/ITPR2/GNA11/NPR1/PLCB1/PLCB4	1.01109674526489
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/385	78/9376	1.56110556110556	PLCG2/PLCB1/PIP5K1C/PLCB4/PLCG1	1.02969619414615
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/385	78/9376	1.56110556110556	C1QA/C1QB/C1QC/CD14/NOD1	1.02969619414615
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/385	99/9376	1.47595434868162	FCGR2B/FCGR2C/FCGR2A/C1QA/C1QB/C1QC	0.98512450511149
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/385	59/9376	1.65106757649131	PIK3R3/KRAS/CTNNA2/SOS1	1.03806854143196
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/385	122/9376	1.3973174366617	PPARG/PIK3R3/PPP2R2A/CD36/SCD/IGF1R/RPTOR	0.914039147919817
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/385	122/9376	1.3973174366617	PIK3R3/PPP2R2A/KRAS/VAV2/SOS1/PAK2/PLCG1	0.914039147919817
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/385	23/9376	2.11767363071711	FUT9/LARGE1	1.1104920651122
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/385	23/9376	2.11767363071711	AQP1/CA4	1.1104920651122
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/385	42/9376	1.73951762523191	AOC1/CYP1B1/AFMID	0.993919657882042
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/385	103/9376	1.41863573319884	COL6A2/COL4A1/COL15A1/KCNQ1/COL9A3/COL4A2	0.884009194184105
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/385	104/9376	1.404995004995	PLPP3/GDPD5/DGKH/PLAAT3/GPD1L/PLD1	0.859392638390183
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/385	24/9376	2.02943722943723	HS6ST1/HS3ST3A1	1.04487718469646
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/385	63/9376	1.54623788909503	PTGR3/PLAAT3/HPGD/HPGDS	0.900159146086305
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/385	235/9376	1.2435700469743	PPARG/MGLL/RPS6KA2/FGFR1/KDM3A/NPR1/KRAS/COX4I2/SLC25A29/SOS1/MT-ND1/RPTOR	0.78247948609367
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/385	105/9376	1.39161410018553	PLCG2/CARD10/CD14/RIPK1/ERC1/PLCG1	0.835029240212829
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/385	170/9376	1.28928953399542	IGF2/PIK3R3/LRP5/PLCG2/KRAS/RB1/IGF1R/SOS1/PLCG1	0.787650769131384
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/385	149/9376	1.30755687265754	GNGT1/KCNJ6/MGLL/ITPR2/GNB4/PLCB1/MT-ND1/PLCB4	0.783069509713579
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/385	44/9376	1.66044864226682	MGAT4A/FUT8/TUSC3	0.908636187289229
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/385	150/9376	1.29883982683983	PIK3R3/LRP5/CCNE1/KRAS/RARB/CTNNA2/RB1/SOS1	0.763465443678494
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/385	107/9376	1.36560262167739	SLC2A1/PHKA2/ITPR2/PHKB/PLCB1/PLCB4	0.787039905760712
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/385	217/9376	1.23449637919684	PIK3R3/ADRB2/CYP1B1/RPS6KA2/DLL4/KLF4/KRAS/JAK2/RB1/SOS1/PAQR7	0.723192615300399
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/385	26/9376	1.87332667332667	SCARB1/APOA1	0.922719284587055
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/385	109/9376	1.34054569283927	SLC2A1/PIK3R3/RPS6KA2/CD36/PPARGC1B/NR1H3	0.739998881595057
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/385	154/9376	1.26510372744139	KCNJ6/MEF2C/ITPR2/NPR1/KRAS/PLCB1/ROCK2/PLCB4	0.686397415659027
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/385	89/9376	1.36815992995768	GNGT1/KCNJ6/GLUL/GNB4/PLCL1	0.722114063849786
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/385	133/9376	1.28174982911825	PIK3R3/TPTEP2-CSNK1E/KLF2/KRAS/PLK2/IGF1R/SOS1	0.677165789538668
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/385	133/9376	1.28174982911825	GNGT1/KCNJ6/PPP2R2A/ITPR2/GNB4/PLCB1/PLCB4	0.677165789538668
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/385	90/9376	1.35295815295815	SLC2A1/AQP1/SCARB1/ABCG2/SLC10A1	0.69621301426759
NA	NA	hsa03272	Virion - Hepatitis viruses	3/385	48/9376	1.52207792207792	SCARB1/CLDN5/SLC10A1	0.750366923690586
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/385	48/9376	1.52207792207792	PIK3R3/PLCB1/PLCB4	0.750366923690586
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/385	157/9376	1.24092977086608	PIK3R3/HIPK2/ITPR2/HLA-G/CCNE1/MRAS/KRAS/RB1	0.62995625198092
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/385	205/9376	1.18796325625594	PXN/PIK3R3/H2BC15/HLA-G/CCNE1/KRAS/YWHAH/RB1/UBR4/H2BC6	0.563058537590963
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/385	50/9376	1.46119480519481	AMD1/P4HA2/AOC1	0.676602670487506
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/385	50/9376	1.46119480519481	PECAM1/CD36/SDC2	0.676602670487506
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/385	30/9376	1.62354978354978	ABCG2/FOLR2	0.70783311385372
NA	NA	hsa04981	Folate transport and metabolism	2/385	31/9376	1.57117720988689	ABCG2/FOLR2	0.659134537996585
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/385	75/9376	1.29883982683983	CGA/ITPR2/PLCB1/PLCB4	0.537670599942295
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/385	53/9376	1.37848566527812	PLCB1/KL/PLCB4	0.57177022087214
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/385	76/9376	1.28174982911825	ITPR2/KCNQ1/PLCB1/PLCB4	0.510318117753459
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/385	77/9376	1.26510372744139	PIK3R3/KRAS/PLD1/RB1	0.483342603378025
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/385	169/9376	1.15281641435488	PIK3R3/TAX1BP1/MRAS/KRAS/CTSL/DDIT4/IGF1R/RPTOR	0.41482630694594
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/385	78/9376	1.24888444888445	FCGR2C/FCGR2A/JAK2/MARCKSL1	0.456732899409397
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/385	102/9376	1.19378660555131	ITPR2/TRPC1/KCNQ1/PLCB1/PLCB4	0.407194871660512
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/385	224/9376	1.08719851576994	SLC2A1/PIK3R3/NRP1/HLA-G/CRTC1/CCNE1/KRAS/TLN1/TRRAP/RB1	0.273329873469522
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	11/385	248/9376	1.08018433179724	TUBB2B/ACTR3B/PODXL/SNX9/CD14/NOD1/TUBB2A/TNFRSF10A/ROCK2/RIPK1/TUBA1B	0.264813147509123
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/385	83/9376	1.1736504459396	BCOR/AUTS2/CBX2/DCAF7	0.328813003880247
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/385	37/9376	1.31639171639172	PPARG/KRAS	0.39901367763083
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/385	275/9376	1.06268713105077	C1QA/PIK3R3/TUBB2B/C1QB/NOTCH1/C1QC/ITPR2/HSPA6/TUBB2A/COX4I2/TUBA1B/MT-ND1	0.218329383352698
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/385	109/9376	1.11712141069939	SPP1/PIK3R3/CD14/RIPK1/CCL3	0.254502449306536
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/385	38/9376	1.28174982911825	PIK3R3/KRAS	0.360114433973073
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/385	181/9376	1.07638659682859	FCGR2B/FCGR2C/FCGR2A/CD14/MRC1/ARHGEF12/KSR1/JAK2	0.214729931996471
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/385	86/9376	1.1327091513138	SLC2A1/GNA11/PLCB1/PLCB4	0.25583163393684
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/385	86/9376	1.1327091513138	GJA1/LAMA2/ITGA2/CTNNA2	0.25583163393684
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/385	87/9376	1.1196895058964	PIK3R3/KRAS/SOS1/MSH3	0.232082943042191
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/385	65/9376	1.123996003996	PLPP3/MGLL/DGKH	0.207576511291276
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/385	41/9376	1.18796325625594	ALAS1/PHGDH	0.249585718726053
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/385	41/9376	1.18796325625594	KRAS/RB1	0.249585718726053
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/385	163/9376	1.04584495259342	PIK3R3/CCNE1/KRAS/JAK2/SLC10A1/RB1/SOS1	0.122179065404433
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/385	90/9376	1.08236652236652	PIK3R3/KRAS/JAK2/PLCG1	0.162468678881415
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/385	66/9376	1.10696576151122	CYP1B1/HSD17B2/STS	0.180448766942209
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	10/385	238/9376	1.02324566190112	F13A1/FCGR2A/C1QA/PIK3R3/RPS4Y1/PLCG2/C1QB/C1QC/NRP1/PLCG1	0.0751652009156741
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/385	42/9376	1.15967841682127	CP/TFRC	0.214609513016511
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/385	117/9376	1.04073704073704	CECR2/RUVBL1/SMARCA1/TRRAP/BAZ2B	0.091751330402652
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/385	93/9376	1.04745147325792	ADRB2/ITPR2/PLCB1/PLCB4	0.0951610014905919
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/385	143/9376	1.02181454908728	FCGR2A/C1QA/C1QB/C1QC/H2BC15/H2BC6	0.0543944820236763
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/385	144/9376	1.01471861471861	C1QA/C1QB/C1QC/SCD/CD14/RIPK1	0.0368308964387588
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/385	19/9376	1.28174982911825	HYAL2	0.25438069596202
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/385	95/9376	1.0253998632946	FLT1/TEK/CTSL/CCL3	0.0514882106981347
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/385	195/9376	0.999107559107559	FCGR2A/PIK3R3/PLCG2/H2BC15/PLCB1/H2BC6/PLCB4/PLCG1	-0.00260593619443439
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/385	70/9376	1.04371057513915	SLC2A1/CD36/JAK2	0.0759566882394125
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/385	70/9376	1.04371057513915	LAMA2/ABL1/HLA-G	0.0759566882394125
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/385	45/9376	1.08236652236652	ABCG2/ABCA1	0.114605351138053
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/385	20/9376	1.21766233766234	SQLE	0.201634658720651
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/385	46/9376	1.05883681535855	CP/ALAS1	0.0827750126629141
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/385	227/9376	0.965547228102294	PIK3R3/CYP1B1/PTK2/ABL1/KRAS/PLD1/COX4I2/SOS1/MT-ND1	-0.108733229617834
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/385	101/9376	0.964485019930564	KIT/KRAS/PLCB1/PLCB4	-0.07425527437519
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/385	22/9376	1.10696576151122	AOC1	0.103936825711078
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	8/385	205/9376	0.950370605004751	SLC2A1/PIK3R3/CD36/PDK4/PLCB1/COX4I2/MT-ND1/PLCB4	-0.14866870857727
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/385	23/9376	1.05883681535855	GLUL	0.0584587618392904
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/385	23/9376	1.05883681535855	MSH3	0.0584587618392904
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/385	23/9376	1.05883681535855	PREP	0.0584587618392904
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/385	158/9376	0.924806838730889	ABL1/CCNE1/PDS5B/DDX11/YWHAH/RB1	-0.197242518640358
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/385	187/9376	0.911618862421001	CARD18/ITPR2/NOD1/PLCB1/NLRP1/RIPK1/PLCB4	-0.252614496221546
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/385	54/9376	0.901972101972102	AMD1/PHGDH	-0.149487206108526
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/385	54/9376	0.901972101972102	CGA/HLA-G	-0.149487206108526
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/385	82/9376	0.890972442191954	HLA-G/HSPA6/CTSL	-0.205188908067167
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/385	136/9376	0.895339954163484	FCGR2B/PIK3R3/HSPA6/CCNE1/CD46	-0.254405439780244
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/385	26/9376	0.936663336663337	PLAAT3	-0.06691878591034
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/385	110/9376	0.885572609208973	PIK3R3/RPS6KA2/KRAS/IGF1R	-0.249799861877038
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/385	191/9376	0.892527367920038	NTRK2/GNGT1/H2BC15/GNB4/KRAS/SOS1/H2BC6	-0.310518151816771
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/385	138/9376	0.882364012798796	RPS6KA2/ITPR2/CCNE1/YWHAH/IGF1R	-0.288073142216554
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/385	56/9376	0.869758812615955	GLI3/TPTEP2-CSNK1E	-0.202276955504951
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/385	56/9376	0.869758812615955	CD14/HSPA6	-0.202276955504951
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/385	27/9376	0.901972101972102	SCD	-0.105550670544998
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/385	112/9376	0.869758812615955	LAMA2/HSPA6/JAK2/BIRC7	-0.286926122409798
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/385	298/9376	0.898945349952061	TNFRSF19/CSH1/ACVRL1/BMPR2/CSF1R/LIFR/TNFRSF10A/IL1RAP/TNFRSF25/CCL3/ACVR2B	-0.366843940144387
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/385	28/9376	0.869758812615955	FUT9	-0.142817035774951
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/385	86/9376	0.849531863485352	SCN9A/PLCB1/PLCB4	-0.290066727417692
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/385	29/9376	0.839767129422302	GNGT1	-0.178824284020988
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/385	30/9376	0.811774891774892	PLAAT3	-0.213666924398499
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/385	119/9376	0.818596529520899	VEGFC/PIK3R3/DAB2IP/RIPK1	-0.412093670762971
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/385	31/9376	0.785588604943444	KL	-0.247429262539718
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/385	32/9376	0.761038961038961	PCCA	-0.280186803248637
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/385	32/9376	0.761038961038961	RPTOR	-0.280186803248637
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/385	32/9376	0.761038961038961	BIRC7	-0.280186803248637
Human Diseases	Immune disease	hsa05310	Asthma	1/385	32/9376	0.761038961038961	PRG2	-0.280186803248637
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/385	205/9376	0.831574279379158	PIK3R3/PLCG2/NCOR2/HLA-G/CCNE1/RIPK1/RB1	-0.504532331661387
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/385	34/9376	0.716271963330787	POLR1B	-0.342952350722265
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/385	154/9376	0.790689829650868	ADRB2/PPP2R2A/KCNQ1/PLCB1/PLCB4	-0.541938664482029
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/385	35/9376	0.695807050092764	FCSK	-0.37307700762302
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/385	157/9376	0.775581106791298	PPARG/PIK3R3/MAP3K11/COX4I2/NR1H3	-0.586785453417646
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/385	36/9376	0.676479076479076	KL	-0.402431706277522
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/385	36/9376	0.676479076479076	POLA1	-0.402431706277522
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/385	100/9376	0.730597402597403	CSF1R/TNFRSF10A/CCL3	-0.560445533945789
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/385	37/9376	0.658195858195858	FCSK	-0.431062257906481
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/385	70/9376	0.695807050092764	CYP1B1/HPGDS	-0.528601808307897
NA	NA	hsa04382	Cornified envelope formation	7/385	217/9376	0.785588604943444	SPTLC2/PPP2R2A/COL4A1/CLDN5/KRT7/COL4A2/ST14	-0.661250028986578
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/385	38/9376	0.640874914559125	FCSK	-0.459010489105902
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/385	39/9376	0.624442224442224	HLA-G	-0.486314687627435
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/385	105/9376	0.695807050092764	TAX1BP1/MRAS/KRAS	-0.648623243439906
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/385	388/9376	0.815959298433525	PIK3R3/TUBB2B/LRP5/TPTEP2-CSNK1E/APOE/ITPR2/TUBB2A/KRAS/PLCB1/COX4I2/TUBA1B/MT-ND1/PLCB4	-0.766143665511952
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	10/385	308/9376	0.790689829650868	PPARG/TUBB2B/DNAH8/TUBB2A/PLCB1/HIP1/COX4I2/TUBA1B/MT-ND1/PLCB4	-0.772897562749052
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/385	75/9376	0.649419913419913	GLUL/PHGDH	-0.630761326134645
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/385	75/9376	0.649419913419913	PIK3R3/MSH3	-0.630761326134645
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/385	75/9376	0.649419913419913	CCNE1/TNFRSF10A	-0.630761326134645
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/385	41/9376	0.59398162812797	SYCP3	-0.539128706206697
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/385	168/9376	0.724799010513296	CSH1/PIK3R3/LIFR/JAK2/SOS1	-0.744790246669522
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/385	109/9376	0.670272846419635	IL1RAP/JAK2/PLCG1	-0.716490415270505
NA	NA	hsa04082	Neuroactive ligand signaling	6/385	199/9376	0.734268746329048	ADRB2/GNGT1/GNB4/GNA11/PLCB1/PLCB4	-0.784026627983331
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/385	79/9376	0.61653789248726	CYP1B1/HPGDS	-0.708233701785653
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/385	44/9376	0.553482880755608	GTF2I	-0.614312130913097
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/385	44/9376	0.553482880755608	POLG2	-0.614312130913097
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/385	44/9376	0.553482880755608	HLA-G	-0.614312130913097
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/385	144/9376	0.676479076479076	PIK3R3/ITPR2/PLCB1/PLCB4	-0.80955754721272
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/385	45/9376	0.541183261183261	HLA-G	-0.6384007962133
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/385	116/9376	0.629825347066726	PCCA/PHGDH/ME3	-0.830122496066705
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/385	47/9376	0.518154186239293	ME3	-0.685253838215626
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/385	47/9376	0.518154186239293	PIK3R3	-0.685253838215626
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/385	48/9376	0.507359307359307	PCCA	-0.708057677578679
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/385	180/9376	0.676479076479076	PIK3R3/HLA-G/NECTIN2/JAK2/SRSF4	-0.906882766389435
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/385	85/9376	0.573017570664629	ADSS1/IMPDH1	-0.818276804998621
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/385	480/9376	0.761038961038961	TUBB2B/DNAH8/LRP5/TPTEP2-CSNK1E/ITPR2/TUBB2A/KRAS/PLCB1/HIP1/VAPB/COX4I2/TUBA1B/MT-ND1/PLCB4/PLCG1	-1.1121473555554
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/385	57/9376	0.427249943039417	SCD	-0.897490617599717
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/385	59/9376	0.412766894122826	HPGDS	-0.936290234239027
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/385	99/9376	0.491984782893874	LAMA2/ITGA2	-1.05148369949142
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/385	168/9376	0.579839208410637	GLUL/TNFRSF10A/JAK2/RIPK1	-1.13710223278039
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/385	268/9376	0.636092265943012	TUBB2B/ITPR2/TUBB2A/COX4I2/TUBA1B/MT-ND1/PLCG1	-1.25071735398305
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/385	63/9376	0.386559472273758	GLI3	-1.01090406329671
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/385	174/9376	0.559844752948201	ERO1A/HSPA6/TUSC3/MARCHF6	-1.21269447015786
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/385	105/9376	0.46387136672851	LAMA2/ITGA2	-1.14317407132415
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/385	250/9376	0.584477922077922	HYAL2/AP3B2/AP3D1/PSAP/CTSL/RPTOR	-1.37795768207924
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/385	72/9376	0.338239538239538	RIPK1	-1.1663911539874
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/385	73/9376	0.33360611990749	HPGDS	-1.18274991014091
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/385	73/9376	0.33360611990749	BICD1	-1.18274991014091
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/385	154/9376	0.474413897790521	ADSS1/ALAS1/AFMID	-1.36082938457607
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/385	82/9376	0.296990814063985	IMPDH1	-1.32305712540462
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/385	83/9376	0.293412611484901	FAR2	-1.33794716428403
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/385	83/9376	0.293412611484901	RIPK1	-1.33794716428403
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/385	368/9376	0.595595708639187	NRG3/TUBB2B/DNAH8/NUP210L/TUBB2A/VAPB/COX4I2/TUBA1B/MT-ND1	-1.63771180748839
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/385	87/9376	0.279922376474101	COX4I2	-1.39626053959457
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/385	173/9376	0.422310637339539	PIK3R3/TNFRSF10A/JAK2	-1.58695537773092
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/385	138/9376	0.352945605119518	COX4I2/MT-ND1	-1.58454055729931
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/385	142/9376	0.343003475397842	BIRC7/CBL	-1.6323914576374
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/385	103/9376	0.236439288866473	PPP2R2A	-1.61236759175354
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/385	108/9376	0.225493025493025	NUP210L	-1.67515964530424
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/385	243/9376	0.300657367324034	RBM17/HSPA6/SRSF4	-2.28559046819437
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/385	370/9376	0.394917514917515	CSH1/ADRB2/APLNR/CGA/VIPR1/PTH2R	-2.45731864971561
Genetic Information Processing	Translation	hsa03010	Ribosome	1/385	222/9376	0.10969930969931	RPS4Y1	-2.77792008231932
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/385	449/9376	0.0542388569114627	ANO2	-4.24975481035499