ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 56/752 489/18639 0.114519427402863 2.83846756298133 1.84239130340706e-12 9.13077663425182e-10 GO:0060589 nucleoside-triphosphatase regulator activity 56/752 490/18639 0.114285714285714 2.83267477203647 2.00236329698505e-12 9.13077663425182e-10 GO:0003779 actin binding 47/752 443/18639 0.106094808126411 2.62965575620767 1.51746847559181e-09 4.61310416579911e-07 GO:0005085 guanyl-nucleotide exchange factor activity 31/752 230/18639 0.134782608695652 3.34070883441258 3.87626168161926e-09 8.83787663409191e-07 GO:0019838 growth factor binding 23/752 136/18639 0.169117647058824 4.19173380788486 5.24161763280884e-09 9.56071056224332e-07 GO:0019199 transmembrane receptor protein kinase activity 16/752 78/18639 0.205128205128205 5.08428805237316 6.97586680069753e-08 1.06033175370602e-05 GO:0051015 actin filament binding 27/752 209/18639 0.129186602870813 3.20200676982592 9.55372757491047e-08 1.24471422118833e-05 GO:0005096 GTPase activator activity 31/752 271/18639 0.114391143911439 2.83528794064536 1.82117682361155e-07 2.07614157891716e-05 GO:0005021 vascular endothelial growth factor receptor activity 12/752 51/18639 0.235294117647059 5.8319774718398 6.35390609546949e-07 6.43862484340908e-05 GO:0038064 collagen receptor activity 12/752 53/18639 0.226415094339623 5.61190285026094 9.91485248047043e-07 9.04234546218903e-05 GO:0008081 phosphoric diester hydrolase activity 15/752 87/18639 0.172413793103448 4.27343176815847 1.86872735194325e-06 0.000116680739370182 GO:0045296 cadherin binding 33/752 334/18639 0.0988023952095808 2.44890670786087 2.11534226336279e-06 0.000116680739370182 GO:0016500 protein-hormone receptor activity 13/752 67/18639 0.194029850746269 4.80920530327088 2.28961724055224e-06 0.000116680739370182 GO:0046332 SMAD binding 14/752 79/18639 0.177215189873418 4.39243872879073 2.92626785283185e-06 0.000116680739370182 GO:0005004 GPI-linked ephrin receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0005008 hepatocyte growth factor receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0005009 insulin receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0005011 macrophage colony-stimulating factor receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0005018 platelet-derived growth factor alpha-receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0005020 stem cell factor receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0008288 boss receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0036332 placental growth factor receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0038062 protein tyrosine kinase collagen receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0060175 brain-derived neurotrophic factor receptor activity 11/752 49/18639 0.224489795918367 5.56418258792879 3.07054577289954e-06 0.000116680739370182 GO:0004713 protein tyrosine kinase activity 19/752 140/18639 0.135714285714286 3.36380129179331 3.58968556411772e-06 0.000119326586783437 GO:0005006 epidermal growth factor receptor activity 11/752 50/18639 0.22 5.45289893617021 3.7943761148242e-06 0.000119326586783437 GO:0005007 fibroblast growth factor receptor activity 11/752 50/18639 0.22 5.45289893617021 3.7943761148242e-06 0.000119326586783437 GO:0005017 platelet-derived growth factor receptor activity 11/752 50/18639 0.22 5.45289893617021 3.7943761148242e-06 0.000119326586783437 GO:0005019 platelet-derived growth factor beta-receptor activity 11/752 50/18639 0.22 5.45289893617021 3.7943761148242e-06 0.000119326586783437 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/752 60/18639 0.2 4.95718085106383 4.01339312731176e-06 0.000122007151070278 GO:0051020 GTPase binding 31/752 315/18639 0.0984126984126984 2.43924772036474 4.64917307010681e-06 0.000128871047922521 GO:0005010 insulin-like growth factor receptor activity 11/752 51/18639 0.215686274509804 5.34597934918648 4.66309712877544e-06 0.000128871047922521 GO:0005030 neurotrophin receptor activity 11/752 51/18639 0.215686274509804 5.34597934918648 4.66309712877544e-06 0.000128871047922521 GO:0005003 ephrin receptor activity 11/752 53/18639 0.207547169811321 5.14424427940586 6.93396941978416e-06 0.000180679431738376 GO:0005005 transmembrane-ephrin receptor activity 11/752 53/18639 0.207547169811321 5.14424427940586 6.93396941978416e-06 0.000180679431738376 GO:0141003 histone H2AX kinase activity 33/752 354/18639 0.0932203389830508 2.31055039668229 7.38123960417898e-06 0.000186991403305867 GO:0140996 histone H3 kinase activity 33/752 357/18639 0.092436974789916 2.29113400679421 8.81181697916125e-06 0.000217199380675542 GO:0035173 histone kinase activity 33/752 360/18639 0.0916666666666667 2.27204122340426 1.04928619514761e-05 0.000251828686835426 GO:0031267 small GTPase binding 28/752 283/18639 0.0989399293286219 2.45231561536727 1.20418860068115e-05 0.000281594872774668 GO:0035401 histone H3Y41 kinase activity 16/752 115/18639 0.139130434782609 3.44847363552266 1.51330489353039e-05 0.000336618064121883 GO:0140801 histone H2AXY142 kinase activity 16/752 115/18639 0.139130434782609 3.44847363552266 1.51330489353039e-05 0.000336618064121883 GO:0005543 phospholipid binding 40/752 497/18639 0.0804828973843058 1.99484138875808 2.78270952976915e-05 0.000604245497892729 GO:0017124 SH3 domain binding 15/752 115/18639 0.130434782608696 3.2329440333025 5.97664611739361e-05 0.00126760494396813 GO:0008035 high-density lipoprotein particle binding 5/752 13/18639 0.384615384615385 9.53304009819967 0.00010359839097699 0.00214731210388669 GO:0004629 phospholipase C activity 7/752 29/18639 0.241379310344828 5.98280447542186 0.000121332902492039 0.00245901349050532 GO:0071889 14-3-3 protein binding 7/752 33/18639 0.212121212121212 5.25761605415861 0.000288570563785228 0.00572122509069843 GO:0050431 transforming growth factor beta binding 6/752 24/18639 0.25 6.19647606382979 0.000304925755708238 0.00591685721714708 GO:0042578 phosphoric ester hydrolase activity 29/752 363/18639 0.0798898071625344 1.98014111130649 0.000386876753271027 0.00735065831214951 GO:0001618 virus receptor activity 11/752 81/18639 0.135802469135802 3.36598699763593 0.000395763580119827 0.00736604867488331 GO:0046965 nuclear retinoid X receptor binding 5/752 17/18639 0.294117647058824 7.28997183979975 0.000435365983191753 0.00788123263636121 GO:0140272 exogenous protein binding 11/752 82/18639 0.134146341463415 3.32493837571354 0.000440726825059673 0.00788123263636121 GO:0004435 phosphatidylinositol phospholipase C activity 6/752 26/18639 0.230769230769231 5.7198240589198 0.000486872270182469 0.00839023366800582 GO:0001540 amyloid-beta binding 11/752 83/18639 0.132530120481928 3.28487887721097 0.000489890171694034 0.00839023366800582 GO:0003712 transcription coregulator activity 36/752 495/18639 0.0727272727272727 1.80261121856867 0.000496790151395082 0.00839023366800582 GO:0001784 phosphotyrosine residue binding 8/752 47/18639 0.170212765957447 4.21887732005432 0.000526640092709103 0.00873265026455822 GO:0035091 phosphatidylinositol binding 24/752 284/18639 0.0845070422535211 2.09458345819598 0.0005429570613183 0.00884244357004088 GO:0034713 type I transforming growth factor beta receptor binding 4/752 11/18639 0.363636363636364 9.01305609284333 0.000691116097399958 0.0108672048418752 GO:0048185 activin binding 4/752 11/18639 0.363636363636364 9.01305609284333 0.000691116097399958 0.0108672048418752 GO:0046875 ephrin receptor binding 6/752 28/18639 0.214285714285714 5.31126519756839 0.000743763840817892 0.0114968241156935 GO:0015245 fatty acid transmembrane transporter activity 5/752 19/18639 0.263157894736842 6.52260638297872 0.000765007241519033 0.0116281100710893 GO:0017166 vinculin binding 4/752 12/18639 0.333333333333333 8.26196808510638 0.0010037037100118 0.0150061931726355 GO:0033218 amide binding 21/752 247/18639 0.0850202429149798 2.10730360065466 0.00108971480061909 0.0158438036002311 GO:0031210 phosphatidylcholine binding 6/752 30/18639 0.2 4.95718085106383 0.00109447327501596 0.0158438036002311 GO:0038024 cargo receptor activity 9/752 65/18639 0.138461538461538 3.43189443535188 0.00114032849171965 0.0162496810070051 GO:0071813 lipoprotein particle binding 6/752 32/18639 0.1875 4.64735704787234 0.00155970990912813 0.0215523551079523 GO:0071814 protein-lipid complex binding 6/752 32/18639 0.1875 4.64735704787234 0.00155970990912813 0.0215523551079523 GO:0030165 PDZ domain binding 10/752 83/18639 0.120481927710843 2.98625352473725 0.00183197075147041 0.0249366764976271 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/752 23/18639 0.217391304347826 5.38824005550416 0.00193656802400816 0.0256508158526248 GO:0008028 monocarboxylic acid transmembrane transporter activity 9/752 70/18639 0.128571428571429 3.18675911854103 0.00194068672569201 0.0256508158526248 GO:0005178 integrin binding 15/752 161/18639 0.093167701863354 2.30924573807321 0.00223625828947006 0.0291352508570956 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/752 24/18639 0.208333333333333 5.16373005319149 0.00236594756829761 0.0299686691984364 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/752 24/18639 0.208333333333333 5.16373005319149 0.00236594756829761 0.0299686691984364 GO:0045309 protein phosphorylated amino acid binding 8/752 59/18639 0.135593220338983 3.36080057699243 0.00242966173060156 0.0303541301138167 GO:0042974 nuclear retinoic acid receptor binding 5/752 25/18639 0.2 4.95718085106383 0.00286052637231785 0.0347840006873851 GO:0120020 cholesterol transfer activity 5/752 25/18639 0.2 4.95718085106383 0.00286052637231785 0.0347840006873851 GO:0005024 transforming growth factor beta receptor activity 4/752 16/18639 0.25 6.19647606382979 0.00324436120483955 0.0379340694719702 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/752 16/18639 0.25 6.19647606382979 0.00324436120483955 0.0379340694719702 GO:0070411 I-SMAD binding 4/752 16/18639 0.25 6.19647606382979 0.00324436120483955 0.0379340694719702 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/752 26/18639 0.192307692307692 4.76652004909984 0.00342568211092151 0.0390527760645053 GO:0005112 Notch binding 5/752 26/18639 0.192307692307692 4.76652004909984 0.00342568211092151 0.0390527760645053 GO:0003714 transcription corepressor activity 17/752 204/18639 0.0833333333333333 2.0654920212766 0.00383155197535521 0.0431404370558512 GO:0038191 neuropilin binding 4/752 17/18639 0.235294117647059 5.8319774718398 0.00410866742688503 0.0454586326793744 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 25/752 349/18639 0.0716332378223496 1.77549457416326 0.00413713433375885 0.0454586326793744 GO:0004620 phospholipase activity 11/752 109/18639 0.100917431192661 2.50132978723404 0.00453905106602022 0.0492811258596481 GO:0140297 DNA-binding transcription factor binding 32/752 488/18639 0.0655737704918033 1.62530519707011 0.00498041314784885 0.0524248925407843 GO:0050997 quaternary ammonium group binding 6/752 40/18639 0.15 3.71788563829787 0.00502865250488951 0.0524248925407843 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/752 18/18639 0.222222222222222 5.50797872340426 0.00511602569751075 0.0524248925407843 GO:0008525 phosphatidylcholine transporter activity 4/752 18/18639 0.222222222222222 5.50797872340426 0.00511602569751075 0.0524248925407843 GO:0098641 cadherin binding involved in cell-cell adhesion 4/752 18/18639 0.222222222222222 5.50797872340426 0.00511602569751075 0.0524248925407843 GO:0004674 protein serine/threonine kinase activity 29/752 433/18639 0.0669745958429561 1.66002592010221 0.00547940710475927 0.0555246586615606 GO:0042169 SH2 domain binding 6/752 41/18639 0.146341463414634 3.62720550077841 0.00569393226100655 0.0570644639784393 GO:0005319 lipid transporter activity 15/752 178/18639 0.0842696629213483 2.08869979679656 0.00575876719980357 0.0570869096328354 GO:0098632 cell-cell adhesion mediator activity 7/752 55/18639 0.127272727272727 3.15456963249516 0.00637220406694214 0.0624887108500133 GO:0097110 scaffold protein binding 8/752 70/18639 0.114285714285714 2.83267477203647 0.00702958152934321 0.0682018973910746 GO:1990782 protein tyrosine kinase binding 11/752 117/18639 0.094017094017094 2.33029869067103 0.00769574668797481 0.0738791682045581 GO:0008526 phosphatidylinositol transfer activity 3/752 11/18639 0.272727272727273 6.75979206963249 0.00846532443883309 0.0769712869146289 GO:0019864 IgG binding 3/752 11/18639 0.272727272727273 6.75979206963249 0.00846532443883309 0.0769712869146289 GO:0120015 sterol transfer activity 5/752 32/18639 0.15625 3.87279753989362 0.00859588120134749 0.0769712869146289 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/752 45/18639 0.133333333333333 3.30478723404255 0.00900656678817337 0.0769712869146289 GO:0008373 sialyltransferase activity 4/752 21/18639 0.19047619047619 4.72112462006079 0.00909211572572174 0.0769712869146289 GO:0005539 glycosaminoglycan binding 18/752 242/18639 0.0743801652892562 1.84357965535432 0.00950973142116638 0.0769712869146289 GO:0140416 transcription regulator inhibitor activity 5/752 33/18639 0.151515151515152 3.75544003868472 0.00980189832315876 0.0769712869146289 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7/752 60/18639 0.116666666666667 2.89168882978723 0.0102072428001996 0.0769712869146289 GO:0098531 ligand-modulated transcription factor activity 7/752 60/18639 0.116666666666667 2.89168882978723 0.0102072428001996 0.0769712869146289 GO:0004676 3-phosphoinositide-dependent protein kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0004711 ribosomal protein S6 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0035175 histone H3S10 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0035979 histone H2AXS139 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0044022 histone H3S28 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0044023 histone H4S1 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0044024 histone H2AS1 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0044025 histone H2BS14 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0072354 histone H3T3 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0072371 histone H2AS121 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0072518 Rho-dependent protein serine/threonine kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0140823 histone H2BS36 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0140855 histone H3S57 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0140995 histone H2A kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0140997 histone H4 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0140998 histone H2B kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:1990244 histone H2AT120 kinase activity 18/752 245/18639 0.073469387755102 1.82100521059488 0.0107114168097696 0.0769712869146289 GO:0005243 gap junction channel activity 4/752 22/18639 0.181818181818182 4.50652804642166 0.0107643558834221 0.0769712869146289 GO:0005025 transforming growth factor beta receptor activity, type I 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0005026 transforming growth factor beta receptor activity, type II 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0016361 activin receptor activity, type I 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0016362 activin receptor activity, type II 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0017002 activin receptor activity 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0035259 nuclear glucocorticoid receptor binding 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/752 12/18639 0.25 6.19647606382979 0.0109525313484402 0.0769712869146289 GO:0004677 DNA-dependent protein kinase activity 18/752 246/18639 0.0731707317073171 1.81360275038921 0.011137794693687 0.0769712869146289 GO:0140857 histone H3T45 kinase activity 18/752 246/18639 0.0731707317073171 1.81360275038921 0.011137794693687 0.0769712869146289 GO:0015026 coreceptor activity 7/752 61/18639 0.114754098360656 2.84428409487269 0.0111405810008016 0.0769712869146289 GO:0098631 cell adhesion mediator activity 8/752 76/18639 0.105263157894737 2.60904255319149 0.011386479992986 0.0780787199519038 GO:0035402 histone H3T11 kinase activity 18/752 247/18639 0.0728744939271255 1.80626022913257 0.0115775467008266 0.0782127599344728 GO:0035403 histone H3T6 kinase activity 18/752 247/18639 0.0728744939271255 1.80626022913257 0.0115775467008266 0.0782127599344728 GO:0004679 AMP-activated protein kinase activity 18/752 248/18639 0.0725806451612903 1.79897692175704 0.0120309550382634 0.0806781690801191 GO:0005154 epidermal growth factor receptor binding 5/752 35/18639 0.142857142857143 3.54084346504559 0.0125521253942241 0.0833608406436611 GO:0005158 insulin receptor binding 4/752 23/18639 0.173913043478261 4.31059204440333 0.0126228375380355 0.0833608406436611 GO:0051219 phosphoprotein binding 9/752 93/18639 0.0967741935483871 2.39863589567605 0.0127052158437159 0.0833608406436611 GO:0005035 death receptor activity 3/752 13/18639 0.230769230769231 5.7198240589198 0.0138171655974307 0.0875087154503947 GO:0005172 vascular endothelial growth factor receptor binding 3/752 13/18639 0.230769230769231 5.7198240589198 0.0138171655974307 0.0875087154503947 GO:0008417 fucosyltransferase activity 3/752 13/18639 0.230769230769231 5.7198240589198 0.0138171655974307 0.0875087154503947 GO:0031994 insulin-like growth factor I binding 3/752 13/18639 0.230769230769231 5.7198240589198 0.0138171655974307 0.0875087154503947 GO:0070123 transforming growth factor beta receptor activity, type III 3/752 13/18639 0.230769230769231 5.7198240589198 0.0138171655974307 0.0875087154503947 GO:0015149 hexose transmembrane transporter activity 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0030552 cAMP binding 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0048027 mRNA 5'-UTR binding 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0050699 WW domain binding 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0055056 D-glucose transmembrane transporter activity 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/752 24/18639 0.166666666666667 4.13098404255319 0.0146742155319831 0.0892192304344573 GO:0035591 signaling adaptor activity 11/752 129/18639 0.0852713178294574 2.11352671944582 0.0153494037843786 0.0927063327904193 GO:0120013 lipid transfer activity 7/752 65/18639 0.107692307692308 2.66925122749591 0.0154972068020328 0.092983240812197 GO:0042805 actinin binding 5/752 37/18639 0.135135135135135 3.34944652098907 0.0157818822556138 0.0940723961903254 GO:0016298 lipase activity 11/752 130/18639 0.0846153846153846 2.09726882160393 0.0161797563633002 0.0952255438482599 GO:0003713 transcription coactivator activity 18/752 256/18639 0.0703125 1.74275889295213 0.0161841658952635 0.0952255438482599 GO:0019763 immunoglobulin receptor activity 3/752 14/18639 0.214285714285714 5.31126519756839 0.0170665035907521 0.0985104511061136 GO:0032454 histone H3K9 demethylase activity 3/752 14/18639 0.214285714285714 5.31126519756839 0.0170665035907521 0.0985104511061136 GO:0098821 BMP receptor activity 3/752 14/18639 0.214285714285714 5.31126519756839 0.0170665035907521 0.0985104511061136 GO:0050840 extracellular matrix binding 7/752 67/18639 0.104477611940299 2.58957208637663 0.0180771101971397 0.103687575470386 GO:0005160 transforming growth factor beta receptor binding 4/752 26/18639 0.153846153846154 3.81321603927987 0.0193787620254341 0.107154566861242 GO:0015145 monosaccharide transmembrane transporter activity 4/752 26/18639 0.153846153846154 3.81321603927987 0.0193787620254341 0.107154566861242 GO:0034237 protein kinase A regulatory subunit binding 4/752 26/18639 0.153846153846154 3.81321603927987 0.0193787620254341 0.107154566861242 GO:0043548 phosphatidylinositol 3-kinase binding 4/752 26/18639 0.153846153846154 3.81321603927987 0.0193787620254341 0.107154566861242 GO:0017046 peptide hormone binding 6/752 53/18639 0.113207547169811 2.80595142513047 0.0193865170308168 0.107154566861242 GO:0051018 protein kinase A binding 6/752 53/18639 0.113207547169811 2.80595142513047 0.0193865170308168 0.107154566861242 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 17/752 243/18639 0.0699588477366255 1.73399330181245 0.0199208425404706 0.109444628897043 GO:0140161 monocarboxylate:sodium symporter activity 3/752 15/18639 0.2 4.95718085106383 0.0207049479914707 0.11307133274384 GO:0005516 calmodulin binding 15/752 207/18639 0.072463768115942 1.79608001850139 0.0209306023899457 0.113623270116848 GO:0015144 carbohydrate transmembrane transporter activity 5/752 40/18639 0.125 3.09823803191489 0.0215929606494957 0.115839883013765 GO:0032451 demethylase activity 5/752 40/18639 0.125 3.09823803191489 0.0215929606494957 0.115839883013765 GO:0016922 nuclear receptor binding 11/752 137/18639 0.0802919708029197 1.99010910079205 0.0229631144715705 0.122469943848376 GO:0019207 kinase regulator activity 19/752 287/18639 0.0662020905923345 1.64087867892357 0.0241600455120567 0.126952109932599 GO:0015562 efflux transmembrane transporter activity 3/752 16/18639 0.1875 4.64735704787234 0.0247343141730009 0.126952109932599 GO:0031435 mitogen-activated protein kinase kinase kinase binding 3/752 16/18639 0.1875 4.64735704787234 0.0247343141730009 0.126952109932599 GO:0170055 lipid transmembrane transporter activity 6/752 56/18639 0.107142857142857 2.65563259878419 0.0247953014117402 0.126952109932599 GO:0045499 chemorepellent activity 4/752 28/18639 0.142857142857143 3.54084346504559 0.0249171356117711 0.126952109932599 GO:0051119 sugar transmembrane transporter activity 4/752 28/18639 0.142857142857143 3.54084346504559 0.0249171356117711 0.126952109932599 GO:0051393 alpha-actinin binding 4/752 28/18639 0.142857142857143 3.54084346504559 0.0249171356117711 0.126952109932599 GO:0141052 histone H3 demethylase activity 4/752 28/18639 0.142857142857143 3.54084346504559 0.0249171356117711 0.126952109932599 GO:0008013 beta-catenin binding 9/752 106/18639 0.0849056603773585 2.10446356884785 0.0274977653870749 0.139322011294513 GO:0003785 actin monomer binding 4/752 29/18639 0.137931034482759 3.41874541452678 0.0280081728681341 0.140348646460101 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 4/752 29/18639 0.137931034482759 3.41874541452678 0.0280081728681341 0.140348646460101 GO:0030169 low-density lipoprotein particle binding 3/752 17/18639 0.176470588235294 4.37398310387985 0.0291540956185972 0.145292542099239 GO:0004879 nuclear receptor activity 6/752 59/18639 0.101694915254237 2.52060043274432 0.0311274055161303 0.151922189822751 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/752 44/18639 0.113636363636364 2.81658002901354 0.0312781862793677 0.151922189822751 GO:0031624 ubiquitin conjugating enzyme binding 4/752 30/18639 0.133333333333333 3.30478723404255 0.0313172935160934 0.151922189822751 GO:0032452 histone demethylase activity 4/752 30/18639 0.133333333333333 3.30478723404255 0.0313172935160934 0.151922189822751 GO:0033612 receptor serine/threonine kinase binding 4/752 30/18639 0.133333333333333 3.30478723404255 0.0313172935160934 0.151922189822751 GO:0019955 cytokine binding 11/752 144/18639 0.0763888888888889 1.89336768617021 0.031622055457453 0.152588966016916 GO:0004706 JUN kinase kinase kinase activity 3/752 18/18639 0.166666666666667 4.13098404255319 0.0339617096028145 0.162103381911425 GO:0070064 proline-rich region binding 3/752 18/18639 0.166666666666667 4.13098404255319 0.0339617096028145 0.162103381911425 GO:0051213 dioxygenase activity 8/752 93/18639 0.0860215053763441 2.13212079615649 0.0341270277708264 0.162103381911425 GO:0140457 protein demethylase activity 4/752 31/18639 0.129032258064516 3.19818119423473 0.0348463030093016 0.164662323028409 GO:0106310 protein serine kinase activity 22/752 361/18639 0.0609418282548476 1.51049832026876 0.0364817744339806 0.171501949916445 GO:0005200 structural constituent of cytoskeleton 9/752 112/18639 0.0803571428571429 1.99172444908815 0.0373274537135661 0.174492910568116 GO:0019209 kinase activator activity 11/752 148/18639 0.0743243243243243 1.84219558654399 0.0375006693764812 0.174492910568116 GO:0005520 insulin-like growth factor binding 3/752 19/18639 0.157894736842105 3.91356382978723 0.0391527244122594 0.179433591276284 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/752 19/18639 0.157894736842105 3.91356382978723 0.0391527244122594 0.179433591276284 GO:0046624 sphingolipid transporter activity 3/752 19/18639 0.157894736842105 3.91356382978723 0.0391527244122594 0.179433591276284 GO:0005201 extracellular matrix structural constituent 12/752 168/18639 0.0714285714285714 1.7704217325228 0.0398284585139148 0.181617770823451 GO:0140938 histone H3 methyltransferase activity 5/752 47/18639 0.106382978723404 2.63679832503395 0.0400780075637092 0.181846482080113 GO:0030296 protein tyrosine kinase activator activity 4/752 33/18639 0.121212121212121 3.00435203094778 0.0425680136047423 0.192188259443193 GO:0032266 phosphatidylinositol-3-phosphate binding 5/752 48/18639 0.104166666666667 2.58186502659574 0.0433124741556328 0.193632237401652 GO:0038187 pattern recognition receptor activity 5/752 48/18639 0.104166666666667 2.58186502659574 0.0433124741556328 0.193632237401652 GO:0008201 heparin binding 12/752 172/18639 0.0697674418604651 1.72924913409203 0.0462571228142314 0.205787785397946 GO:0090482 vitamin transmembrane transporter activity 4/752 34/18639 0.117647058823529 2.9159887359199 0.0467611934872069 0.207020429419091 GO:0002020 protease binding 10/752 136/18639 0.0735294117647059 1.82249295994994 0.0487725506879248 0.214881962451147 GO:0004721 phosphoprotein phosphatase activity 12/752 175/18639 0.0685714285714286 1.69960486322188 0.0515244580880508 0.225914931616838 GO:0019887 protein kinase regulator activity 16/752 255/18639 0.0627450980392157 1.55519399249061 0.0543872612557256 0.237326230934075 GO:0030295 protein kinase activator activity 10/752 139/18639 0.0719424460431655 1.78315857951936 0.0550366777331523 0.237883649728127 GO:0070851 growth factor receptor binding 10/752 139/18639 0.0719424460431655 1.78315857951936 0.0550366777331523 0.237883649728127 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/752 36/18639 0.111111111111111 2.75398936170213 0.0558090472450377 0.240084203242804 GO:0005548 phospholipid transporter activity 6/752 68/18639 0.0882352941176471 2.18699155193993 0.0560854815053399 0.240140653205962 GO:0140517 protein-RNA adaptor activity 3/752 22/18639 0.136363636363636 3.37989603481625 0.05695841858561 0.242415296292655 GO:0030159 signaling receptor complex adaptor activity 5/752 52/18639 0.0961538461538462 2.38326002454992 0.0577775824369896 0.242415296292655 GO:0004955 prostaglandin receptor activity 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0005031 tumor necrosis factor receptor activity 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0005131 growth hormone receptor binding 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0031434 mitogen-activated protein kinase kinase binding 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0051864 histone H3K36 demethylase activity 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0070097 delta-catenin binding 2/752 10/18639 0.2 4.95718085106383 0.0590089865975542 0.242415296292655 GO:0022829 wide pore channel activity 4/752 37/18639 0.108108108108108 2.67955721679126 0.0606608248195133 0.245878543268427 GO:0030551 cyclic nucleotide binding 4/752 37/18639 0.108108108108108 2.67955721679126 0.0606608248195133 0.245878543268427 GO:0043394 proteoglycan binding 4/752 37/18639 0.108108108108108 2.67955721679126 0.0606608248195133 0.245878543268427 GO:0008146 sulfotransferase activity 5/752 53/18639 0.0943396226415094 2.33829285427539 0.0617766517501327 0.249293391133279 GO:0140103 catalytic activity, acting on a glycoprotein 3/752 23/18639 0.130434782608696 3.2329440333025 0.063608755742746 0.255555882103015 GO:0000146 microfilament motor activity 4/752 38/18639 0.105263157894737 2.60904255319149 0.0657283927630986 0.262913571052394 GO:0008237 metallopeptidase activity 12/752 184/18639 0.0652173913043478 1.61647201665125 0.0697204978403937 0.273759450033349 GO:0005518 collagen binding 6/752 72/18639 0.0833333333333333 2.0654920212766 0.0701715773151079 0.273759450033349 GO:0004954 prostanoid receptor activity 2/752 11/18639 0.181818181818182 4.50652804642166 0.0702409115217145 0.273759450033349 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/752 11/18639 0.181818181818182 4.50652804642166 0.0702409115217145 0.273759450033349 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/752 11/18639 0.181818181818182 4.50652804642166 0.0702409115217145 0.273759450033349 GO:0070697 activin receptor binding 2/752 11/18639 0.181818181818182 4.50652804642166 0.0702409115217145 0.273759450033349 GO:0070300 phosphatidic acid binding 3/752 24/18639 0.125 3.09823803191489 0.0705994043442836 0.273985773455262 GO:0030331 nuclear estrogen receptor binding 4/752 40/18639 0.1 2.47859042553192 0.076499754506728 0.29542222475234 GO:0004222 metalloendopeptidase activity 8/752 110/18639 0.0727272727272727 1.80261121856867 0.0767709070902463 0.29542222475234 GO:0004709 MAP kinase kinase kinase activity 3/752 25/18639 0.12 2.9743085106383 0.0779187173859697 0.298249845870381 GO:0043178 alcohol binding 7/752 92/18639 0.0760869565217391 1.88588401942646 0.0781597732050669 0.298249845870381 GO:0008179 adenylate cyclase binding 2/752 12/18639 0.166666666666667 4.13098404255319 0.0820985875563693 0.307227757238522 GO:0015166 polyol transmembrane transporter activity 2/752 12/18639 0.166666666666667 4.13098404255319 0.0820985875563693 0.307227757238522 GO:0070410 co-SMAD binding 2/752 12/18639 0.166666666666667 4.13098404255319 0.0820985875563693 0.307227757238522 GO:0070679 inositol 1,4,5 trisphosphate binding 2/752 12/18639 0.166666666666667 4.13098404255319 0.0820985875563693 0.307227757238522 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/752 41/18639 0.0975609756097561 2.41813700051894 0.0821968999629379 0.307227757238522 GO:0042562 hormone binding 7/752 94/18639 0.074468085106383 1.84575882752377 0.0854211688685861 0.31210231891383 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/752 26/18639 0.115384615384615 2.8599120294599 0.0855543637373437 0.31210231891383 GO:0019865 immunoglobulin binding 3/752 26/18639 0.115384615384615 2.8599120294599 0.0855543637373437 0.31210231891383 GO:0050681 nuclear androgen receptor binding 3/752 26/18639 0.115384615384615 2.8599120294599 0.0855543637373437 0.31210231891383 GO:0070412 R-SMAD binding 3/752 26/18639 0.115384615384615 2.8599120294599 0.0855543637373437 0.31210231891383 GO:0120014 phospholipid transfer activity 3/752 26/18639 0.115384615384615 2.8599120294599 0.0855543637373437 0.31210231891383 GO:0048487 beta-tubulin binding 4/752 42/18639 0.0952380952380952 2.36056231003039 0.0880965947548613 0.32009599369097 GO:0005044 scavenger receptor activity 3/752 27/18639 0.111111111111111 2.75398936170213 0.0934934449506193 0.334093849196124 GO:0008375 acetylglucosaminyltransferase activity 4/752 43/18639 0.0930232558139535 2.30566551212271 0.0941945639590529 0.334093849196124 GO:0017154 semaphorin receptor activity 2/752 13/18639 0.153846153846154 3.81321603927987 0.0945133915489036 0.334093849196124 GO:0043560 insulin receptor substrate binding 2/752 13/18639 0.153846153846154 3.81321603927987 0.0945133915489036 0.334093849196124 GO:0045159 myosin II binding 2/752 13/18639 0.153846153846154 3.81321603927987 0.0945133915489036 0.334093849196124 GO:0046975 histone H3K36 methyltransferase activity 2/752 13/18639 0.153846153846154 3.81321603927987 0.0945133915489036 0.334093849196124 GO:0070700 BMP receptor binding 2/752 13/18639 0.153846153846154 3.81321603927987 0.0945133915489036 0.334093849196124 GO:0001216 DNA-binding transcription activator activity 26/752 491/18639 0.0529531568228106 1.31249187502708 0.0964466048828871 0.339611211016189 GO:0044325 transmembrane transporter binding 9/752 136/18639 0.0661764705882353 1.64024366395494 0.0993815944995844 0.347264422159468 GO:0140789 histone phosphatase activity 9/752 136/18639 0.0661764705882353 1.64024366395494 0.0993815944995844 0.347264422159468 GO:0004725 protein tyrosine phosphatase activity 7/752 98/18639 0.0714285714285714 1.7704217325228 0.101055032344095 0.351764082052729 GO:0050698 proteoglycan sulfotransferase activity 3/752 28/18639 0.107142857142857 2.65563259878419 0.101722602071281 0.352741494635013 GO:0004065 arylsulfatase activity 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:0005545 1-phosphatidylinositol binding 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:0008195 phosphatidate phosphatase activity 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:0019992 diacylglycerol binding 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:0071933 Arp2/3 complex binding 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:1990825 sequence-specific mRNA binding 2/752 14/18639 0.142857142857143 3.54084346504559 0.107421206208596 0.364193829227655 GO:0030971 receptor tyrosine kinase binding 6/752 81/18639 0.0740740740740741 1.83599290780142 0.108597149761306 0.366817039193744 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/752 181/18639 0.0607734806629834 1.5063256729752 0.115848195904776 0.389865515369579 GO:0001965 G-protein alpha-subunit binding 3/752 30/18639 0.1 2.47859042553192 0.118995981979526 0.397525038700834 GO:0001968 fibronectin binding 3/752 30/18639 0.1 2.47859042553192 0.118995981979526 0.397525038700834 GO:0004953 icosanoid receptor activity 2/752 15/18639 0.133333333333333 3.30478723404255 0.12076216901123 0.397599632268021 GO:0034483 heparan sulfate sulfotransferase activity 2/752 15/18639 0.133333333333333 3.30478723404255 0.12076216901123 0.397599632268021 GO:0050700 CARD domain binding 2/752 15/18639 0.133333333333333 3.30478723404255 0.12076216901123 0.397599632268021 GO:0051371 muscle alpha-actinin binding 2/752 15/18639 0.133333333333333 3.30478723404255 0.12076216901123 0.397599632268021 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 25/752 484/18639 0.0516528925619835 1.28026364955161 0.124061762509297 0.406993983483736 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/752 48/18639 0.0833333333333333 2.0654920212766 0.127487226512879 0.415469613306013 GO:0070273 phosphatidylinositol-4-phosphate binding 3/752 31/18639 0.0967741935483871 2.39863589567605 0.12801201901205 0.415469613306013 GO:0070325 lipoprotein particle receptor binding 3/752 31/18639 0.0967741935483871 2.39863589567605 0.12801201901205 0.415469613306013 GO:1901981 phosphatidylinositol phosphate binding 11/752 185/18639 0.0594594594594595 1.47375646923519 0.1291433521889 0.417655096440698 GO:0042277 peptide binding 14/752 249/18639 0.0562248995983936 1.39358497821072 0.132911271690088 0.425854707629047 GO:0042054 histone methyltransferase activity 5/752 67/18639 0.0746268656716418 1.84969434741188 0.133170101801531 0.425854707629047 GO:0003688 DNA replication origin binding 2/752 16/18639 0.125 3.09823803191489 0.13448043398812 0.425854707629047 GO:0005159 insulin-like growth factor receptor binding 2/752 16/18639 0.125 3.09823803191489 0.13448043398812 0.425854707629047 GO:0005521 lamin binding 2/752 16/18639 0.125 3.09823803191489 0.13448043398812 0.425854707629047 GO:0015378 sodium:chloride symporter activity 2/752 16/18639 0.125 3.09823803191489 0.13448043398812 0.425854707629047 GO:0042910 xenobiotic transmembrane transporter activity 3/752 32/18639 0.09375 2.32367852393617 0.137261914433891 0.433158705756778 GO:0030145 manganese ion binding 5/752 68/18639 0.0735294117647059 1.82249295994994 0.139287928809165 0.438036520944686 GO:0019888 protein phosphatase regulator activity 7/752 107/18639 0.0654205607476635 1.62150775502088 0.141444149669377 0.443288881438049 GO:0016279 protein-lysine N-methyltransferase activity 5/752 69/18639 0.072463768115942 1.79608001850139 0.145526656280523 0.450012752634217 GO:0005496 steroid binding 7/752 108/18639 0.0648148148148148 1.60649379432624 0.146354026326436 0.450012752634217 GO:0140311 protein sequestering activity 3/752 33/18639 0.0909090909090909 2.25326402321083 0.146731304516806 0.450012752634217 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0008429 phosphatidylethanolamine binding 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0008484 sulfuric ester hydrolase activity 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0019198 transmembrane receptor protein phosphatase activity 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0036041 long-chain fatty acid binding 2/752 17/18639 0.117647058823529 2.9159887359199 0.148523945770723 0.450012752634217 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/752 89/18639 0.0674157303370786 1.67095983743725 0.150102285080324 0.451793016479391 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/752 89/18639 0.0674157303370786 1.67095983743725 0.150102285080324 0.451793016479391 GO:0016278 lysine N-methyltransferase activity 5/752 70/18639 0.0714285714285714 1.7704217325228 0.15188290162315 0.45415477468955 GO:0016782 transferase activity, transferring sulphur-containing groups 5/752 70/18639 0.0714285714285714 1.7704217325228 0.15188290162315 0.45415477468955 GO:0019210 kinase inhibitor activity 6/752 90/18639 0.0666666666666667 1.65239361702128 0.155732989058819 0.461624978084991 GO:0140793 histone H2AXY142 phosphatase activity 6/752 90/18639 0.0666666666666667 1.65239361702128 0.155732989058819 0.461624978084991 GO:0008376 acetylgalactosaminyltransferase activity 3/752 34/18639 0.0882352941176471 2.18699155193993 0.156405831390639 0.461624978084991 GO:0051427 hormone receptor binding 3/752 34/18639 0.0882352941176471 2.18699155193993 0.156405831390639 0.461624978084991 GO:0000400 four-way junction DNA binding 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0015373 monoatomic anion:sodium symporter activity 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0030228 lipoprotein particle receptor activity 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0031690 adrenergic receptor binding 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0034185 apolipoprotein binding 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0035615 clathrin adaptor activity 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:1901611 phosphatidylglycerol binding 2/752 18/18639 0.111111111111111 2.75398936170213 0.162844225291711 0.469980802107724 GO:0004864 protein phosphatase inhibitor activity 4/752 53/18639 0.0754716981132075 1.87063428342031 0.16493577175148 0.473872910942679 GO:0005343 organic acid:sodium symporter activity 3/752 35/18639 0.0857142857142857 2.12450607902736 0.166271196821993 0.473872910942679 GO:0043015 gamma-tubulin binding 3/752 35/18639 0.0857142857142857 2.12450607902736 0.166271196821993 0.473872910942679 GO:0140566 histone reader activity 3/752 35/18639 0.0857142857142857 2.12450607902736 0.166271196821993 0.473872910942679 GO:0043539 protein serine/threonine kinase activator activity 5/752 73/18639 0.0684931506849315 1.69766467502186 0.171621375391487 0.487597178682355 GO:0015485 cholesterol binding 4/752 54/18639 0.0740740740740741 1.83599290780142 0.172856367393723 0.488065037346981 GO:0051287 NAD binding 4/752 54/18639 0.0740740740740741 1.83599290780142 0.172856367393723 0.488065037346981 GO:0045505 dynein intermediate chain binding 3/752 36/18639 0.0833333333333333 2.0654920212766 0.176313210419898 0.488777353212514 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0008381 mechanosensitive monoatomic ion channel activity 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0042577 lipid phosphatase activity 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0042800 histone H3K4 methyltransferase activity 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0042834 peptidoglycan binding 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0043395 heparan sulfate proteoglycan binding 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0097001 ceramide binding 2/752 19/18639 0.105263157894737 2.60904255319149 0.177396166571647 0.488777353212514 GO:0048029 monosaccharide binding 5/752 74/18639 0.0675675675675676 1.67472326049454 0.17841187088782 0.490095259788228 GO:0140313 molecular sequestering activity 4/752 55/18639 0.0727272727272727 1.80261121856867 0.1809053441475 0.495452474061622 GO:0001221 transcription coregulator binding 7/752 115/18639 0.0608695652173913 1.50870721554117 0.182872989084043 0.499341814504931 GO:0019212 phosphatase inhibitor activity 4/752 56/18639 0.0714285714285714 1.7704217325228 0.189076025726278 0.514738314813033 GO:0016505 peptidase activator activity involved in apoptotic process 2/752 20/18639 0.1 2.47859042553192 0.19213784404741 0.516360299514967 GO:0030742 GTP-dependent protein binding 2/752 20/18639 0.1 2.47859042553192 0.19213784404741 0.516360299514967 GO:0031418 L-ascorbic acid binding 2/752 20/18639 0.1 2.47859042553192 0.19213784404741 0.516360299514967 GO:0140939 histone H4 methyltransferase activity 2/752 20/18639 0.1 2.47859042553192 0.19213784404741 0.516360299514967 GO:0016757 glycosyltransferase activity 14/752 267/18639 0.052434456928839 1.29963542911786 0.192502743240229 0.516360299514967 GO:0019208 phosphatase regulator activity 7/752 117/18639 0.0598290598290598 1.48291734860884 0.193949424411287 0.518715176138105 GO:0016504 peptidase activator activity 4/752 57/18639 0.0701754385964912 1.73936170212766 0.197361697590724 0.526297860241931 GO:0001846 opsonin binding 2/752 21/18639 0.0952380952380952 2.36056231003039 0.207030329924281 0.543425485559892 GO:0005123 death receptor binding 2/752 21/18639 0.0952380952380952 2.36056231003039 0.207030329924281 0.543425485559892 GO:0015174 basic amino acid transmembrane transporter activity 2/752 21/18639 0.0952380952380952 2.36056231003039 0.207030329924281 0.543425485559892 GO:0036122 BMP binding 2/752 21/18639 0.0952380952380952 2.36056231003039 0.207030329924281 0.543425485559892 GO:0140312 cargo adaptor activity 2/752 21/18639 0.0952380952380952 2.36056231003039 0.207030329924281 0.543425485559892 GO:0000217 DNA secondary structure binding 3/752 39/18639 0.0769230769230769 1.90660801963993 0.207359724753117 0.543425485559892 GO:0033293 monocarboxylic acid binding 5/752 79/18639 0.0632911392405063 1.56872811742526 0.213773589829185 0.55862897972555 GO:0016791 phosphatase activity 14/752 273/18639 0.0512820512820513 1.27107201309329 0.21479261337987 0.559688181149832 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/752 40/18639 0.075 1.85894281914894 0.217969992610932 0.563149913024356 GO:0008093 cytoskeletal anchor activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0008970 phospholipase A1 activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0015377 chloride:monoatomic cation symporter activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0016881 acid-amino acid ligase activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0050321 tau-protein kinase activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0061133 endopeptidase activator activity 2/752 22/18639 0.0909090909090909 2.25326402321083 0.222037521058148 0.563149913024356 GO:0005126 cytokine receptor binding 14/752 275/18639 0.0509090909090909 1.26182785299807 0.222464308443514 0.563149913024356 GO:1901681 sulfur compound binding 14/752 275/18639 0.0509090909090909 1.26182785299807 0.222464308443514 0.563149913024356 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/752 122/18639 0.0573770491803279 1.42214204743634 0.222743900223445 0.563149913024356 GO:0033192 calmodulin-dependent protein phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0140791 histone H2AXS140 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/752 81/18639 0.0617283950617284 1.52999408983452 0.228501391739877 0.563149913024356 GO:0001727 lipid kinase activity 3/752 41/18639 0.0731707317073171 1.81360275038921 0.228688920977879 0.563149913024356 GO:0017080 sodium channel regulator activity 3/752 41/18639 0.0731707317073171 1.81360275038921 0.228688920977879 0.563149913024356 GO:0046943 carboxylic acid transmembrane transporter activity 10/752 188/18639 0.0531914893617021 1.31839916251698 0.229088396636004 0.563149913024356 GO:0005342 organic acid transmembrane transporter activity 10/752 189/18639 0.0529100529100529 1.31142350557244 0.233884548138709 0.572113463245269 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/752 82/18639 0.0609756097560976 1.51133562532434 0.235973978400023 0.572113463245269 GO:0033549 MAP kinase phosphatase activity 5/752 82/18639 0.0609756097560976 1.51133562532434 0.235973978400023 0.572113463245269 GO:0003887 DNA-directed DNA polymerase activity 2/752 23/18639 0.0869565217391304 2.15529602220166 0.23712597489771 0.572113463245269 GO:0005283 amino acid:sodium symporter activity 2/752 23/18639 0.0869565217391304 2.15529602220166 0.23712597489771 0.572113463245269 GO:0017134 fibroblast growth factor binding 2/752 23/18639 0.0869565217391304 2.15529602220166 0.23712597489771 0.572113463245269 GO:0031681 G-protein beta-subunit binding 2/752 23/18639 0.0869565217391304 2.15529602220166 0.23712597489771 0.572113463245269 GO:0008307 structural constituent of muscle 3/752 42/18639 0.0714285714285714 1.7704217325228 0.239503715302726 0.576325562944819 GO:0004857 enzyme inhibitor activity 20/752 416/18639 0.0480769230769231 1.19163001227496 0.240605783821103 0.577453881170648 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/752 83/18639 0.0602409638554217 1.49312676236862 0.243513544649962 0.582898563571563 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/752 43/18639 0.0697674418604651 1.72924913409203 0.250401901653502 0.591427906641401 GO:0048156 tau protein binding 3/752 43/18639 0.0697674418604651 1.72924913409203 0.250401901653502 0.591427906641401 GO:0004860 protein kinase inhibitor activity 5/752 84/18639 0.0595238095238095 1.475351443769 0.251115976449734 0.591427906641401 GO:0017018 myosin phosphatase activity 5/752 84/18639 0.0595238095238095 1.475351443769 0.251115976449734 0.591427906641401 GO:0051117 ATPase binding 5/752 84/18639 0.0595238095238095 1.475351443769 0.251115976449734 0.591427906641401 GO:0005540 hyaluronic acid binding 2/752 24/18639 0.0833333333333333 2.0654920212766 0.252264754038931 0.591427906641401 GO:0030215 semaphorin receptor binding 2/752 24/18639 0.0833333333333333 2.0654920212766 0.252264754038931 0.591427906641401 GO:0035035 histone acetyltransferase binding 2/752 24/18639 0.0833333333333333 2.0654920212766 0.252264754038931 0.591427906641401 GO:0042826 histone deacetylase binding 7/752 127/18639 0.0551181102362205 1.36615220304909 0.252919809435807 0.591443246680657 GO:0001223 transcription coactivator binding 3/752 44/18639 0.0681818181818182 1.68994801740812 0.261371343111537 0.609643644290849 GO:0140030 modification-dependent protein binding 9/752 173/18639 0.0520231213872832 1.28944010576805 0.264843670057067 0.614337164776652 GO:0016209 antioxidant activity 5/752 86/18639 0.0581395348837209 1.44104094507669 0.266493001276475 0.614337164776652 GO:0001848 complement binding 2/752 25/18639 0.08 1.98287234042553 0.267425278965275 0.614337164776652 GO:0003707 nuclear steroid receptor activity 2/752 25/18639 0.08 1.98287234042553 0.267425278965275 0.614337164776652 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/752 25/18639 0.08 1.98287234042553 0.267425278965275 0.614337164776652 GO:0017025 TBP-class protein binding 2/752 25/18639 0.08 1.98287234042553 0.267425278965275 0.614337164776652 GO:0016758 hexosyltransferase activity 10/752 197/18639 0.050761421319797 1.2581677286964 0.273509969823202 0.626736413263217 GO:0008143 poly(A) binding 2/752 26/18639 0.0769230769230769 1.90660801963993 0.282581188567603 0.639488942862665 GO:0030507 spectrin binding 2/752 26/18639 0.0769230769230769 1.90660801963993 0.282581188567603 0.639488942862665 GO:0050750 low-density lipoprotein particle receptor binding 2/752 26/18639 0.0769230769230769 1.90660801963993 0.282581188567603 0.639488942862665 GO:0052742 phosphatidylinositol kinase activity 2/752 26/18639 0.0769230769230769 1.90660801963993 0.282581188567603 0.639488942862665 GO:0097602 cullin family protein binding 2/752 26/18639 0.0769230769230769 1.90660801963993 0.282581188567603 0.639488942862665 GO:0030291 protein serine/threonine kinase inhibitor activity 3/752 46/18639 0.0652173913043478 1.61647201665125 0.28347720844886 0.639928747785546 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/752 132/18639 0.053030303030303 1.31440401353965 0.284221714629338 0.640025194424583 GO:0004386 helicase activity 8/752 155/18639 0.0516129032258065 1.27927247769389 0.288886894371327 0.648928196223277 GO:0008514 organic anion transmembrane transporter activity 13/752 269/18639 0.0483271375464684 1.19783180416041 0.291784435410539 0.650525745914053 GO:0015631 tubulin binding 18/752 385/18639 0.0467532467532468 1.15882149765128 0.293576969271153 0.650525745914053 GO:0032934 sterol binding 4/752 68/18639 0.0588235294117647 1.45799436795995 0.294180185320632 0.650525745914053 GO:0005504 fatty acid binding 3/752 47/18639 0.0638297872340425 1.58207899502037 0.294591154673798 0.650525745914053 GO:0061749 forked DNA-dependent helicase activity 3/752 47/18639 0.0638297872340425 1.58207899502037 0.294591154673798 0.650525745914053 GO:0140359 ABC-type transporter activity 3/752 47/18639 0.0638297872340425 1.58207899502037 0.294591154673798 0.650525745914053 GO:1990518 single-stranded 3'-5' DNA helicase activity 3/752 47/18639 0.0638297872340425 1.58207899502037 0.294591154673798 0.650525745914053 GO:0008266 poly(U) RNA binding 2/752 27/18639 0.0740740740740741 1.83599290780142 0.297708208056962 0.65582098006751 GO:0009378 four-way junction helicase activity 3/752 48/18639 0.0625 1.54911901595745 0.305731416551192 0.668650004543615 GO:0036121 double-stranded DNA helicase activity 3/752 48/18639 0.0625 1.54911901595745 0.305731416551192 0.668650004543615 GO:0043138 3'-5' DNA helicase activity 3/752 48/18639 0.0625 1.54911901595745 0.305731416551192 0.668650004543615 GO:0140658 ATP-dependent chromatin remodeler activity 8/752 158/18639 0.0506329113924051 1.25498249394021 0.306676698673875 0.669112797106637 GO:0046625 sphingolipid binding 2/752 28/18639 0.0714285714285714 1.7704217325228 0.312784023902014 0.675969264925679 GO:0046966 nuclear thyroid hormone receptor binding 2/752 28/18639 0.0714285714285714 1.7704217325228 0.312784023902014 0.675969264925679 GO:0051959 dynein light intermediate chain binding 2/752 28/18639 0.0714285714285714 1.7704217325228 0.312784023902014 0.675969264925679 GO:0097718 disordered domain specific binding 2/752 28/18639 0.0714285714285714 1.7704217325228 0.312784023902014 0.675969264925679 GO:0035254 glutamate receptor binding 3/752 49/18639 0.0612244897959184 1.5175043421624 0.316887701284561 0.683218873691537 GO:0004181 metallocarboxypeptidase activity 2/752 29/18639 0.0689655172413793 1.70937270726339 0.327788165440446 0.68598960641352 GO:0005416 amino acid:monoatomic cation symporter activity 2/752 29/18639 0.0689655172413793 1.70937270726339 0.327788165440446 0.68598960641352 GO:0000182 rDNA binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0001094 TFIID-class transcription factor complex binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0004935 adrenergic receptor activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0005345 purine nucleobase transmembrane transporter activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0008140 cAMP response element binding protein binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0008519 ammonium channel activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0015203 polyamine transmembrane transporter activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0015279 store-operated calcium channel activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0015643 toxic substance binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0019911 structural constituent of myelin sheath 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0031720 haptoglobin binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0042975 peroxisome proliferator activated receptor binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0043121 neurotrophin binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0043208 glycosphingolipid binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0051880 G-quadruplex DNA binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0070513 death domain binding 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0070739 protein-glutamic acid ligase activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0070740 tubulin-glutamic acid ligase activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0140135 mechanosensitive monoatomic cation channel activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0140999 histone H3K4 trimethyltransferase activity 1/752 10/18639 0.1 2.47859042553192 0.337623539742936 0.68598960641352 GO:0008276 protein methyltransferase activity 5/752 95/18639 0.0526315789473684 1.30452127659574 0.337729532104902 0.68598960641352 GO:0030246 carbohydrate binding 13/752 280/18639 0.0464285714285714 1.15077412613982 0.341870065870259 0.689942883579308 GO:0031406 carboxylic acid binding 9/752 187/18639 0.0481283422459893 1.19290448287632 0.342489993500179 0.689942883579308 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/752 30/18639 0.0666666666666667 1.65239361702128 0.342701892830512 0.689942883579308 GO:0008187 poly-pyrimidine tract binding 2/752 30/18639 0.0666666666666667 1.65239361702128 0.342701892830512 0.689942883579308 GO:0035064 methylated histone binding 4/752 74/18639 0.0540540540540541 1.33977860839563 0.349410450104226 0.69084815787803 GO:0043177 organic acid binding 9/752 189/18639 0.0476190476190476 1.1802811550152 0.353907109848512 0.69084815787803 GO:0072349 modified amino acid transmembrane transporter activity 2/752 31/18639 0.0645161290322581 1.59909059711736 0.357508091024888 0.69084815787803 GO:0003725 double-stranded RNA binding 4/752 75/18639 0.0533333333333333 1.32191489361702 0.358656021805933 0.69084815787803 GO:0019902 phosphatase binding 9/752 190/18639 0.0473684210526316 1.17406914893617 0.359634746286177 0.69084815787803 GO:0008170 N-methyltransferase activity 5/752 98/18639 0.0510204081632653 1.264586951802 0.361888330197102 0.69084815787803 GO:0019903 protein phosphatase binding 7/752 144/18639 0.0486111111111111 1.20487034574468 0.36236615115515 0.69084815787803 GO:0001851 complement component C3b binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0003953 NAD+ nucleosidase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0005114 type II transforming growth factor beta receptor binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0005536 D-glucose binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0008432 JUN kinase binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0015205 nucleobase transmembrane transporter activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0032794 GTPase activating protein binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0035252 UDP-xylosyltransferase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0042285 xylosyltransferase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0048407 platelet-derived growth factor binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0097493 structural molecule activity conferring elasticity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0140031 phosphorylation-dependent protein binding 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0140537 transcription regulator activator activity 1/752 11/18639 0.0909090909090909 2.25326402321083 0.364361802565058 0.69084815787803 GO:0140034 methylation-dependent protein binding 4/752 76/18639 0.0526315789473684 1.30452127659574 0.367898771294055 0.696107218714062 GO:0008194 UDP-glycosyltransferase activity 7/752 145/18639 0.0482758620689655 1.19656089508437 0.368989140268267 0.696724836282939 GO:0070717 poly-purine tract binding 2/752 32/18639 0.0625 1.54911901595745 0.372191169464288 0.699155534561674 GO:0003925 G protein activity 3/752 54/18639 0.0555555555555556 1.37699468085106 0.372576304601945 0.699155534561674 GO:0140463 chromatin-protein adaptor activity 3/752 54/18639 0.0555555555555556 1.37699468085106 0.372576304601945 0.699155534561674 GO:0004032 aldose reductase (NADPH) activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0004875 complement receptor activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0005078 MAP-kinase scaffold activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0005095 GTPase inhibitor activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0005165 neurotrophin receptor binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0008603 cAMP-dependent protein kinase regulator activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0016208 AMP binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0031543 peptidyl-proline dioxygenase activity 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0034452 dynactin binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0035197 siRNA binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0042301 phosphate ion binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0097677 STAT family protein binding 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/752 12/18639 0.0833333333333333 2.0654920212766 0.390022094838574 0.712825952891342 GO:0008186 ATP-dependent activity, acting on RNA 4/752 79/18639 0.0506329113924051 1.25498249394021 0.395559993487444 0.721501428121098 GO:0015020 glucuronosyltransferase activity 2/752 34/18639 0.0588235294117647 1.45799436795995 0.401132663191098 0.724908046142226 GO:0015035 protein-disulfide reductase activity 2/752 34/18639 0.0588235294117647 1.45799436795995 0.401132663191098 0.724908046142226 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/752 34/18639 0.0588235294117647 1.45799436795995 0.401132663191098 0.724908046142226 GO:0016831 carboxy-lyase activity 2/752 34/18639 0.0588235294117647 1.45799436795995 0.401132663191098 0.724908046142226 GO:0019842 vitamin binding 7/752 150/18639 0.0466666666666667 1.15667553191489 0.402178638098721 0.724908046142226 GO:0004722 protein serine/threonine phosphatase activity 5/752 103/18639 0.0485436893203883 1.2031992356951 0.402196788758735 0.724908046142226 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 6/752 128/18639 0.046875 1.16183926196809 0.41347978889627 0.727091022279795 GO:0002161 aminoacyl-tRNA editing activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0005542 folic acid binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0032396 inhibitory MHC class I receptor activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0035325 Toll-like receptor binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0035673 oligopeptide transmembrane transporter activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0046974 histone H3K9 methyltransferase activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0051011 microtubule minus-end binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0061459 L-arginine transmembrane transporter activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0089720 caspase binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0097157 pre-mRNA intronic binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0140666 annealing activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0140852 histone ubiquitin ligase activity 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:1901338 catecholamine binding 1/752 13/18639 0.0769230769230769 1.90660801963993 0.414647820112714 0.727091022279795 GO:0034061 DNA polymerase activity 2/752 35/18639 0.0571428571428571 1.41633738601824 0.415366691455892 0.727091022279795 GO:0017116 single-stranded DNA helicase activity 3/752 58/18639 0.0517241379310345 1.28202953044754 0.416508265876474 0.727692602450851 GO:0005506 iron ion binding 7/752 154/18639 0.0454545454545455 1.12663201160542 0.42870554239475 0.738839076800354 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/752 36/18639 0.0555555555555556 1.37699468085106 0.429428660928597 0.738839076800354 GO:0016409 palmitoyltransferase activity 2/752 36/18639 0.0555555555555556 1.37699468085106 0.429428660928597 0.738839076800354 GO:0031072 heat shock protein binding 6/752 131/18639 0.0458015267175573 1.13523225596882 0.435124664343808 0.738839076800354 GO:0005344 oxygen carrier activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0008191 metalloendopeptidase inhibitor activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0008474 palmitoyl-(protein) hydrolase activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0008559 ABC-type xenobiotic transporter activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0015926 glucosidase activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0030983 mismatched DNA binding 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0034236 protein kinase A catalytic subunit binding 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0042813 Wnt receptor activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0043176 amine binding 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0061665 SUMO ligase activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0070742 C2H2 zinc finger domain binding 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0098599 palmitoyl hydrolase activity 1/752 14/18639 0.0714285714285714 1.7704217325228 0.438280636566877 0.738839076800354 GO:0140375 immune receptor activity 7/752 156/18639 0.0448717948717949 1.11218801145663 0.44192065506708 0.742886175712726 GO:0005179 hormone activity 6/752 132/18639 0.0454545454545455 1.12663201160542 0.442310519092116 0.742886175712726 GO:0000287 magnesium ion binding 10/752 230/18639 0.0434782608695652 1.07764801110083 0.450303492303451 0.745382980002107 GO:0005109 frizzled binding 2/752 38/18639 0.0526315789473684 1.30452127659574 0.457000283376997 0.745382980002107 GO:0042887 amide transmembrane transporter activity 2/752 38/18639 0.0526315789473684 1.30452127659574 0.457000283376997 0.745382980002107 GO:0043531 ADP binding 2/752 38/18639 0.0526315789473684 1.30452127659574 0.457000283376997 0.745382980002107 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/752 86/18639 0.0465116279069767 1.15283275606136 0.459126806457006 0.745382980002107 GO:0004089 carbonate dehydratase activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0004129 cytochrome-c oxidase activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0005041 low-density lipoprotein particle receptor activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0005523 tropomyosin binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0015250 water channel activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0015929 hexosaminidase activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0030553 cGMP binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0031005 filamin binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0033130 acetylcholine receptor binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0045504 dynein heavy chain binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0047372 monoacylglycerol lipase activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0050780 dopamine receptor binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0120283 protein serine/threonine kinase binding 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:0140776 protein-containing complex destabilizing activity 1/752 15/18639 0.0666666666666667 1.65239361702128 0.460960527106566 0.745382980002107 GO:1902936 phosphatidylinositol bisphosphate binding 5/752 111/18639 0.045045045045045 1.11648217366302 0.46590450513 0.752044086156743 GO:1901682 sulfur compound transmembrane transporter activity 3/752 63/18639 0.0476190476190476 1.1802811550152 0.469908697840389 0.756774009304701 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/752 39/18639 0.0512820512820513 1.27107201309329 0.470494367626936 0.756774009304701 GO:0008094 ATP-dependent activity, acting on DNA 9/752 210/18639 0.0428571428571429 1.06225303951368 0.474797507768536 0.762350927966382 GO:0008083 growth factor activity 7/752 162/18639 0.0432098765432099 1.07099586288416 0.481209774903508 0.763342618125492 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0016722 oxidoreductase activity, acting on metal ions 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0022858 alanine transmembrane transporter activity 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0140328 floppase activity 1/752 16/18639 0.0625 1.54911901595745 0.482725866647795 0.763342618125492 GO:0004177 aminopeptidase activity 2/752 40/18639 0.05 1.23929521276596 0.483785124206726 0.763342618125492 GO:0015036 disulfide oxidoreductase activity 2/752 40/18639 0.05 1.23929521276596 0.483785124206726 0.763342618125492 GO:0071949 FAD binding 2/752 40/18639 0.05 1.23929521276596 0.483785124206726 0.763342618125492 GO:0001530 lipopolysaccharide binding 2/752 41/18639 0.0487804878048781 1.20906850025947 0.496866980782564 0.778595681226287 GO:0004812 aminoacyl-tRNA ligase activity 2/752 41/18639 0.0487804878048781 1.20906850025947 0.496866980782564 0.778595681226287 GO:0016875 ligase activity, forming carbon-oxygen bonds 2/752 41/18639 0.0487804878048781 1.20906850025947 0.496866980782564 0.778595681226287 GO:0140318 protein transporter activity 2/752 41/18639 0.0487804878048781 1.20906850025947 0.496866980782564 0.778595681226287 GO:0008235 metalloexopeptidase activity 3/752 66/18639 0.0454545454545455 1.12663201160542 0.500874527697024 0.779788624571787 GO:0008569 minus-end-directed microtubule motor activity 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0015278 intracellularly gated calcium channel activity 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0032183 SUMO binding 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0048038 quinone binding 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0070403 NAD+ binding 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0070492 oligosaccharide binding 1/752 17/18639 0.0588235294117647 1.45799436795995 0.503613486702613 0.779788624571787 GO:0019894 kinesin binding 2/752 42/18639 0.0476190476190476 1.1802811550152 0.509735144056556 0.785267654357397 GO:0042056 chemoattractant activity 2/752 42/18639 0.0476190476190476 1.1802811550152 0.509735144056556 0.785267654357397 GO:0051879 Hsp90 protein binding 2/752 42/18639 0.0476190476190476 1.1802811550152 0.509735144056556 0.785267654357397 GO:0016874 ligase activity 7/752 167/18639 0.0419161676646707 1.03893011848643 0.51335703897169 0.789513692313965 GO:0016887 ATP hydrolysis activity 17/752 417/18639 0.0407673860911271 1.01045652839431 0.517773532286201 0.794965423308106 GO:0005372 water transmembrane transporter activity 1/752 18/18639 0.0555555555555556 1.37699468085106 0.523658737373842 0.797290097637636 GO:0015280 ligand-gated sodium channel activity 1/752 18/18639 0.0555555555555556 1.37699468085106 0.523658737373842 0.797290097637636 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/752 18/18639 0.0555555555555556 1.37699468085106 0.523658737373842 0.797290097637636 GO:0032393 MHC class I receptor activity 1/752 18/18639 0.0555555555555556 1.37699468085106 0.523658737373842 0.797290097637636 GO:1990381 ubiquitin-specific protease binding 1/752 18/18639 0.0555555555555556 1.37699468085106 0.523658737373842 0.797290097637636 GO:0016410 N-acyltransferase activity 4/752 94/18639 0.0425531914893617 1.05471933001358 0.528720512236735 0.803655178599837 GO:0016755 aminoacyltransferase activity 20/752 496/18639 0.0403225806451613 0.999431623198353 0.533797249964191 0.810021783639505 GO:0043014 alpha-tubulin binding 2/752 44/18639 0.0454545454545455 1.12663201160542 0.534814793887544 0.810217760839601 GO:0061659 ubiquitin-like protein ligase activity 15/752 372/18639 0.0403225806451613 0.999431623198353 0.538374006835295 0.811673342194954 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0005229 intracellularly calcium-gated chloride channel activity 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0008301 DNA binding, bending 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0030506 ankyrin binding 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0034987 immunoglobulin receptor binding 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0050145 nucleoside monophosphate kinase activity 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0141147 intracellularly calcium-gated channel activity 1/752 19/18639 0.0526315789473684 1.30452127659574 0.542895546862853 0.811673342194954 GO:0008528 G protein-coupled peptide receptor activity 5/752 122/18639 0.040983606557377 1.01581574816882 0.549657929619187 0.820438677271192 GO:0004180 carboxypeptidase activity 2/752 46/18639 0.0434782608695652 1.07764801110083 0.558999344662547 0.826142803588805 GO:0001972 retinoic acid binding 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0015095 magnesium ion transmembrane transporter activity 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0016004 phospholipase activator activity 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0016408 C-acyltransferase activity 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0140664 ATP-dependent DNA damage sensor activity 1/752 20/18639 0.05 1.23929521276596 0.561356478589981 0.826142803588805 GO:0031625 ubiquitin protein ligase binding 12/752 302/18639 0.0397350993377483 0.984870367761026 0.563142667280484 0.826142803588805 GO:0061134 peptidase regulator activity 9/752 226/18639 0.0398230088495575 0.98704928450386 0.563674448907203 0.826142803588805 GO:0061630 ubiquitin protein ligase activity 14/752 353/18639 0.0396600566572238 0.983010367066482 0.56485191359733 0.826142803588805 GO:0043495 protein-membrane adaptor activity 2/752 47/18639 0.0425531914893617 1.05471933001358 0.570750819773159 0.826142803588805 GO:0000510 H3-H4 histone complex chaperone activity 6/752 151/18639 0.0397350993377483 0.984870367761026 0.573263972845764 0.826142803588805 GO:0140584 chromatin extrusion motor activity 6/752 151/18639 0.0397350993377483 0.984870367761026 0.573263972845764 0.826142803588805 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/752 151/18639 0.0397350993377483 0.984870367761026 0.573263972845764 0.826142803588805 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/752 151/18639 0.0397350993377483 0.984870367761026 0.573263972845764 0.826142803588805 GO:0003678 DNA helicase activity 3/752 74/18639 0.0405405405405405 1.00483395629672 0.578574720654534 0.826142803588805 GO:0031491 nucleosome binding 3/752 74/18639 0.0405405405405405 1.00483395629672 0.578574720654534 0.826142803588805 GO:0005248 voltage-gated sodium channel activity 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0009975 cyclase activity 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0010314 phosphatidylinositol-5-phosphate binding 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0015125 bile acid transmembrane transporter activity 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0035613 RNA stem-loop binding 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0051428 peptide hormone receptor binding 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0070182 DNA polymerase binding 1/752 21/18639 0.0476190476190476 1.1802811550152 0.579072786023267 0.826142803588805 GO:0003924 GTPase activity 13/752 331/18639 0.0392749244712991 0.97346451758051 0.5795357803905 0.826142803588805 GO:0015616 DNA translocase activity 6/752 152/18639 0.0394736842105263 0.978390957446808 0.579749335851793 0.826142803588805 GO:0140674 ATP-dependent histone chaperone activity 6/752 152/18639 0.0394736842105263 0.978390957446808 0.579749335851793 0.826142803588805 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/752 48/18639 0.0416666666666667 1.0327460106383 0.58227340252194 0.827154740031167 GO:0140693 molecular condensate scaffold activity 2/752 48/18639 0.0416666666666667 1.0327460106383 0.58227340252194 0.827154740031167 GO:0061775 cohesin loader activity 6/752 153/18639 0.0392156862745098 0.971996245306633 0.586184686235414 0.831415915780245 GO:0001653 peptide receptor activity 5/752 128/18639 0.0390625 0.968199384973404 0.592575636754303 0.833772871718214 GO:0031490 chromatin DNA binding 5/752 128/18639 0.0390625 0.968199384973404 0.592575636754303 0.833772871718214 GO:0001222 transcription corepressor binding 2/752 49/18639 0.0408163265306122 1.0116695614416 0.593566411085233 0.833772871718214 GO:0008238 exopeptidase activity 4/752 102/18639 0.0392156862745098 0.971996245306633 0.593646111063237 0.833772871718214 GO:0015171 amino acid transmembrane transporter activity 4/752 102/18639 0.0392156862745098 0.971996245306633 0.593646111063237 0.833772871718214 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/752 22/18639 0.0454545454545455 1.12663201160542 0.59607446530732 0.833772871718214 GO:0031683 G-protein beta/gamma-subunit complex binding 1/752 22/18639 0.0454545454545455 1.12663201160542 0.59607446530732 0.833772871718214 GO:0034062 5'-3' RNA polymerase activity 1/752 22/18639 0.0454545454545455 1.12663201160542 0.59607446530732 0.833772871718214 GO:0097747 RNA polymerase activity 1/752 22/18639 0.0454545454545455 1.12663201160542 0.59607446530732 0.833772871718214 GO:0140097 catalytic activity, acting on DNA 13/752 336/18639 0.0386904761904762 0.958978438449848 0.60135210429171 0.839866951170045 GO:0032813 tumor necrosis factor receptor superfamily binding 2/752 50/18639 0.04 0.991436170212766 0.604629590623613 0.843001001012508 GO:0003724 RNA helicase activity 3/752 77/18639 0.038961038961039 0.965684581376071 0.605676767251834 0.843001001012508 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/752 130/18639 0.0384615384615385 0.953304009819967 0.606369141079173 0.843001001012508 GO:0004602 glutathione peroxidase activity 1/752 23/18639 0.0434782608695652 1.07764801110083 0.612390305780484 0.846212058896669 GO:0005212 structural constituent of eye lens 1/752 23/18639 0.0434782608695652 1.07764801110083 0.612390305780484 0.846212058896669 GO:0016849 phosphorus-oxygen lyase activity 1/752 23/18639 0.0434782608695652 1.07764801110083 0.612390305780484 0.846212058896669 GO:0070577 lysine-acetylated histone binding 1/752 23/18639 0.0434782608695652 1.07764801110083 0.612390305780484 0.846212058896669 GO:0005272 sodium channel activity 2/752 51/18639 0.0392156862745098 0.971996245306633 0.615463080024585 0.847855290123983 GO:0016830 carbon-carbon lyase activity 2/752 51/18639 0.0392156862745098 0.971996245306633 0.615463080024585 0.847855290123983 GO:0061135 endopeptidase regulator activity 7/752 184/18639 0.0380434782608696 0.942942009713229 0.616368483938816 0.847855290123983 GO:0015370 solute:sodium symporter activity 3/752 79/18639 0.0379746835443038 0.941236870455158 0.623089992922544 0.850862135746586 GO:0005080 protein kinase C binding 2/752 52/18639 0.0384615384615385 0.953304009819967 0.626067380627836 0.850862135746586 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0004622 lysophospholipase activity 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0005315 phosphate transmembrane transporter activity 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0015295 solute:proton symporter activity 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0060229 lipase activator activity 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0070840 dynein complex binding 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0140033 acetylation-dependent protein binding 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0140612 DNA damage sensor activity 1/752 24/18639 0.0416666666666667 1.0327460106383 0.628047938464899 0.850862135746586 GO:0003689 DNA clamp loader activity 6/752 160/18639 0.0375 0.929471409574468 0.629749935996651 0.850862135746586 GO:0099106 ion channel regulator activity 6/752 160/18639 0.0375 0.929471409574468 0.629749935996651 0.850862135746586 GO:0005246 calcium channel regulator activity 2/752 53/18639 0.0377358490566038 0.935317141710157 0.636443326827562 0.85368759962296 GO:0140296 general transcription initiation factor binding 2/752 53/18639 0.0377358490566038 0.935317141710157 0.636443326827562 0.85368759962296 GO:0015101 organic cation transmembrane transporter activity 3/752 81/18639 0.037037037037037 0.917996453900709 0.639970114607924 0.85368759962296 GO:0005251 delayed rectifier potassium channel activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0005537 D-mannose binding 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0008483 transaminase activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0015271 outward rectifier potassium channel activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0015662 P-type ion transporter activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0019707 protein-cysteine S-acyltransferase activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0140358 P-type transmembrane transporter activity 1/752 25/18639 0.04 0.991436170212766 0.643073882610717 0.85368759962296 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/752 54/18639 0.037037037037037 0.917996453900709 0.646592058451624 0.857110403063781 GO:0044389 ubiquitin-like protein ligase binding 12/752 322/18639 0.0372670807453416 0.923698295229285 0.651889637718046 0.86278295599952 GO:0140713 histone chaperone activity 6/752 164/18639 0.0365853658536585 0.906801375194603 0.653407734759627 0.86278295599952 GO:0001637 G protein-coupled chemoattractant receptor activity 1/752 26/18639 0.0384615384615385 0.953304009819967 0.657493590372441 0.86278295599952 GO:0004950 chemokine receptor activity 1/752 26/18639 0.0384615384615385 0.953304009819967 0.657493590372441 0.86278295599952 GO:0008157 protein phosphatase 1 binding 1/752 26/18639 0.0384615384615385 0.953304009819967 0.657493590372441 0.86278295599952 GO:0008198 ferrous iron binding 1/752 26/18639 0.0384615384615385 0.953304009819967 0.657493590372441 0.86278295599952 GO:0070006 metalloaminopeptidase activity 1/752 26/18639 0.0384615384615385 0.953304009819967 0.657493590372441 0.86278295599952 GO:0030170 pyridoxal phosphate binding 2/752 56/18639 0.0357142857142857 0.885210866261398 0.666213810408334 0.870916527168347 GO:0004364 glutathione transferase activity 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0005104 fibroblast growth factor receptor binding 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0008320 protein transmembrane transporter activity 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0008395 steroid hydroxylase activity 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0035255 ionotropic glutamate receptor binding 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/752 27/18639 0.037037037037037 0.917996453900709 0.671331489692268 0.870916527168347 GO:0004601 peroxidase activity 2/752 57/18639 0.0350877192982456 0.86968085106383 0.675690411981953 0.873395354829984 GO:0070279 vitamin B6 binding 2/752 57/18639 0.0350877192982456 0.86968085106383 0.675690411981953 0.873395354829984 GO:0016247 channel regulator activity 6/752 168/18639 0.0357142857142857 0.885210866261398 0.676115263717071 0.873395354829984 GO:0020037 heme binding 5/752 142/18639 0.0352112676056338 0.87274310758166 0.683200898641845 0.877224117957863 GO:0005242 inward rectifier potassium channel activity 1/752 28/18639 0.0357142857142857 0.885210866261398 0.684611025462277 0.877224117957863 GO:0019789 SUMO transferase activity 1/752 28/18639 0.0357142857142857 0.885210866261398 0.684611025462277 0.877224117957863 GO:0051019 mitogen-activated protein kinase binding 1/752 28/18639 0.0357142857142857 0.885210866261398 0.684611025462277 0.877224117957863 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/752 28/18639 0.0357142857142857 0.885210866261398 0.684611025462277 0.877224117957863 GO:0141108 transporter regulator activity 6/752 170/18639 0.0352941176470588 0.87479662077597 0.687103595238224 0.877224117957863 GO:0009055 electron transfer activity 4/752 116/18639 0.0344827586206897 0.854686353631695 0.693478910436034 0.877224117957863 GO:0015294 solute:monoatomic cation symporter activity 4/752 116/18639 0.0344827586206897 0.854686353631695 0.693478910436034 0.877224117957863 GO:0001786 phosphatidylserine binding 2/752 59/18639 0.0338983050847458 0.840200144248107 0.693985634531047 0.877224117957863 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/752 59/18639 0.0338983050847458 0.840200144248107 0.693985634531047 0.877224117957863 GO:0031593 polyubiquitin modification-dependent protein binding 2/752 59/18639 0.0338983050847458 0.840200144248107 0.693985634531047 0.877224117957863 GO:0070888 E-box binding 2/752 59/18639 0.0338983050847458 0.840200144248107 0.693985634531047 0.877224117957863 GO:0004197 cysteine-type endopeptidase activity 3/752 88/18639 0.0340909090909091 0.844974008704062 0.694805015058991 0.877224117957863 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0016417 S-acyltransferase activity 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0043236 laminin binding 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0051861 glycolipid binding 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0097472 cyclin-dependent protein kinase activity 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0099604 ligand-gated calcium channel activity 1/752 29/18639 0.0344827586206897 0.854686353631695 0.697354699034485 0.877224117957863 GO:0003727 single-stranded RNA binding 3/752 89/18639 0.0337078651685393 0.835479918718623 0.702099732055146 0.881976522912249 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0016769 transferase activity, transferring nitrogenous groups 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0048019 receptor antagonist activity 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0051721 protein phosphatase 2A binding 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0070566 adenylyltransferase activity 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0098918 structural constituent of synapse 1/752 30/18639 0.0333333333333333 0.826196808510638 0.709584106144967 0.883943925153943 GO:0016836 hydro-lyase activity 2/752 61/18639 0.0327868852459016 0.812652598535054 0.711419781867318 0.883943925153943 GO:0019905 syntaxin binding 2/752 61/18639 0.0327868852459016 0.812652598535054 0.711419781867318 0.883943925153943 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/752 91/18639 0.032967032967033 0.817117722702829 0.716288948931548 0.887575436719527 GO:0072341 modified amino acid binding 3/752 91/18639 0.032967032967033 0.817117722702829 0.716288948931548 0.887575436719527 GO:0032182 ubiquitin-like protein binding 4/752 120/18639 0.0333333333333333 0.826196808510638 0.718550303215067 0.889169438985266 GO:0017147 Wnt-protein binding 1/752 31/18639 0.032258064516129 0.799545298558682 0.721319973315637 0.890181076676401 GO:0047499 calcium-independent phospholipase A2 activity 1/752 31/18639 0.032258064516129 0.799545298558682 0.721319973315637 0.890181076676401 GO:0052689 carboxylic ester hydrolase activity 3/752 92/18639 0.0326086956521739 0.808236008325624 0.723184816745215 0.890584131685288 GO:0003697 single-stranded DNA binding 4/752 121/18639 0.0330578512396694 0.81936873571303 0.724576124682548 0.890584131685288 GO:0015108 chloride transmembrane transporter activity 4/752 121/18639 0.0330578512396694 0.81936873571303 0.724576124682548 0.890584131685288 GO:0005507 copper ion binding 2/752 63/18639 0.0317460317460317 0.786854103343465 0.728014453116661 0.892009292161251 GO:0004842 ubiquitin-protein transferase activity 16/752 449/18639 0.0356347438752784 0.883239349855471 0.730191592319979 0.892009292161251 GO:0022884 macromolecule transmembrane transporter activity 1/752 32/18639 0.03125 0.774559507978723 0.732582192794712 0.892009292161251 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/752 32/18639 0.03125 0.774559507978723 0.732582192794712 0.892009292161251 GO:0043425 bHLH transcription factor binding 1/752 32/18639 0.03125 0.774559507978723 0.732582192794712 0.892009292161251 GO:0047498 calcium-dependent phospholipase A2 activity 1/752 32/18639 0.03125 0.774559507978723 0.732582192794712 0.892009292161251 GO:0051059 NF-kappaB binding 1/752 32/18639 0.03125 0.774559507978723 0.732582192794712 0.892009292161251 GO:0046906 tetrapyrrole binding 5/752 152/18639 0.0328947368421053 0.81532579787234 0.739013489187799 0.898640402852363 GO:0019787 ubiquitin-like protein transferase activity 17/752 479/18639 0.0354906054279749 0.879666748101097 0.74064947231903 0.899218678074571 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/752 33/18639 0.0303030303030303 0.751088007736944 0.743389856094458 0.899218678074571 GO:0003774 cytoskeletal motor activity 5/752 153/18639 0.0326797385620915 0.809996871088861 0.744176624422677 0.899218678074571 GO:0019001 guanyl nucleotide binding 14/752 400/18639 0.035 0.86750664893617 0.744418971432348 0.899218678074571 GO:0032561 guanyl ribonucleotide binding 14/752 400/18639 0.035 0.86750664893617 0.744418971432348 0.899218678074571 GO:0004896 cytokine receptor activity 3/752 96/18639 0.03125 0.774559507978723 0.74946343180931 0.904114616150914 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/752 34/18639 0.0294117647058824 0.728997183979975 0.753761286182439 0.905705260867437 GO:0019825 oxygen binding 1/752 34/18639 0.0294117647058824 0.728997183979975 0.753761286182439 0.905705260867437 GO:0030332 cyclin binding 1/752 34/18639 0.0294117647058824 0.728997183979975 0.753761286182439 0.905705260867437 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/752 67/18639 0.0298507462686567 0.739877738964751 0.758781164333161 0.910466967794528 GO:0004175 endopeptidase activity 14/752 405/18639 0.0345679012345679 0.856796690307329 0.76029850372304 0.910466967794528 GO:0042626 ATPase-coupled transmembrane transporter activity 3/752 98/18639 0.0306122448979592 0.758752171081198 0.761834312318814 0.910466967794528 GO:0001664 G protein-coupled receptor binding 10/752 297/18639 0.0336700336700337 0.834542230818827 0.763569473619266 0.910466967794528 GO:0004623 phospholipase A2 activity 1/752 35/18639 0.0285714285714286 0.708168693009118 0.763714068380279 0.910466967794528 GO:0016229 steroid dehydrogenase activity 1/752 35/18639 0.0285714285714286 0.708168693009118 0.763714068380279 0.910466967794528 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 2/752 68/18639 0.0294117647058824 0.728997183979975 0.765986743745655 0.911984217096655 GO:0008080 N-acetyltransferase activity 2/752 69/18639 0.0289855072463768 0.718432007400555 0.773004524548402 0.91349449867855 GO:0004033 aldo-keto reductase (NADPH) activity 1/752 36/18639 0.0277777777777778 0.688497340425532 0.773265080021755 0.91349449867855 GO:0055106 ubiquitin-protein transferase regulator activity 1/752 36/18639 0.0277777777777778 0.688497340425532 0.773265080021755 0.91349449867855 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/752 36/18639 0.0277777777777778 0.688497340425532 0.773265080021755 0.91349449867855 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/752 36/18639 0.0277777777777778 0.688497340425532 0.773265080021755 0.91349449867855 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/752 36/18639 0.0277777777777778 0.688497340425532 0.773265080021755 0.91349449867855 GO:0140597 protein carrier chaperone 6/752 188/18639 0.0319148936170213 0.791039497510186 0.77475465908679 0.914070179931633 GO:0005262 calcium channel activity 4/752 131/18639 0.0305343511450382 0.756821503979211 0.779601382074045 0.918600078102751 GO:0019213 deacetylase activity 1/752 37/18639 0.027027027027027 0.669889304197815 0.782430518919978 0.918786459580706 GO:0030280 structural constituent of skin epidermis 1/752 37/18639 0.027027027027027 0.669889304197815 0.782430518919978 0.918786459580706 GO:0004866 endopeptidase inhibitor activity 5/752 161/18639 0.031055900621118 0.769748579357737 0.78278188497172 0.918786459580706 GO:0042393 histone binding 8/752 247/18639 0.0323886639676113 0.80278232405892 0.783979824082783 0.919009768076475 GO:0140299 molecular sensor activity 2/752 71/18639 0.028169014084507 0.698194486065328 0.786490325769674 0.92055344563899 GO:0008017 microtubule binding 9/752 276/18639 0.0326086956521739 0.808236008325624 0.787315446928084 0.92055344563899 GO:0005501 retinoid binding 1/752 38/18639 0.0263157894736842 0.652260638297872 0.79122593069141 0.922759653184867 GO:0019840 isoprenoid binding 1/752 38/18639 0.0263157894736842 0.652260638297872 0.79122593069141 0.922759653184867 GO:0051087 protein-folding chaperone binding 4/752 134/18639 0.0298507462686567 0.739877738964751 0.794303977479992 0.925166318597385 GO:0015081 sodium ion transmembrane transporter activity 5/752 164/18639 0.0304878048780488 0.755667812662169 0.796044460548734 0.926010903087303 GO:0004521 RNA endonuclease activity 2/752 73/18639 0.0273972602739726 0.679065870008744 0.799266106823415 0.926260569236053 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/752 39/18639 0.0256410256410256 0.635536006546645 0.79966623498258 0.926260569236053 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/752 39/18639 0.0256410256410256 0.635536006546645 0.79966623498258 0.926260569236053 GO:0015103 inorganic anion transmembrane transporter activity 5/752 165/18639 0.0303030303030303 0.751088007736944 0.8003216321908 0.926260569236053 GO:0016779 nucleotidyltransferase activity 4/752 136/18639 0.0294117647058824 0.728997183979975 0.8036606676596 0.927597187487553 GO:0099094 ligand-gated monoatomic cation channel activity 4/752 136/18639 0.0294117647058824 0.728997183979975 0.8036606676596 0.927597187487553 GO:0015399 primary active transmembrane transporter activity 5/752 166/18639 0.0301204819277108 0.746563381184312 0.80452782379677 0.927597187487553 GO:0000149 SNARE binding 3/752 106/18639 0.0283018867924528 0.701487856282617 0.806430667090481 0.92767445207042 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/752 40/18639 0.025 0.619647606382979 0.8077657506435 0.92767445207042 GO:0140662 ATP-dependent protein folding chaperone 1/752 40/18639 0.025 0.619647606382979 0.8077657506435 0.92767445207042 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/752 167/18639 0.029940119760479 0.742092941776022 0.808663584864017 0.92767445207042 GO:0019003 GDP binding 2/752 75/18639 0.0266666666666667 0.660957446808511 0.811359667580751 0.928081321061619 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/752 41/18639 0.024390243902439 0.604534250129735 0.815538219890023 0.928081321061619 GO:0008227 G protein-coupled amine receptor activity 1/752 41/18639 0.024390243902439 0.604534250129735 0.815538219890023 0.928081321061619 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/752 41/18639 0.024390243902439 0.604534250129735 0.815538219890023 0.928081321061619 GO:0046982 protein heterodimerization activity 12/752 369/18639 0.032520325203252 0.806045666839647 0.815766663185693 0.928081321061619 GO:0030414 peptidase inhibitor activity 5/752 169/18639 0.029585798816568 0.73331077678459 0.816726109261041 0.928081321061619 GO:0140767 enzyme-substrate adaptor activity 4/752 139/18639 0.0287769784172662 0.713263431807745 0.81704518520306 0.928081321061619 GO:0017022 myosin binding 2/752 76/18639 0.0263157894736842 0.652260638297872 0.817159321066316 0.928081321061619 GO:0016829 lyase activity 6/752 200/18639 0.03 0.743577127659574 0.822088923412702 0.931232146804087 GO:0004520 DNA endonuclease activity 1/752 42/18639 0.0238095238095238 0.590140577507599 0.822996831495717 0.931232146804087 GO:0016859 cis-trans isomerase activity 1/752 42/18639 0.0238095238095238 0.590140577507599 0.822996831495717 0.931232146804087 GO:0005245 voltage-gated calcium channel activity 1/752 43/18639 0.0232558139534884 0.576416378030678 0.830154243052163 0.9370057792866 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/752 43/18639 0.0232558139534884 0.576416378030678 0.830154243052163 0.9370057792866 GO:0016835 carbon-oxygen lyase activity 2/752 79/18639 0.0253164556962025 0.627491246970105 0.833611386166107 0.937794365269749 GO:0008168 methyltransferase activity 6/752 204/18639 0.0294117647058824 0.728997183979975 0.835996746966368 0.937794365269749 GO:0003954 NADH dehydrogenase activity 1/752 44/18639 0.0227272727272727 0.563316005802708 0.837022602335061 0.937794365269749 GO:0016790 thiolester hydrolase activity 1/752 44/18639 0.0227272727272727 0.563316005802708 0.837022602335061 0.937794365269749 GO:0019205 nucleobase-containing compound kinase activity 1/752 44/18639 0.0227272727272727 0.563316005802708 0.837022602335061 0.937794365269749 GO:0030547 signaling receptor inhibitor activity 1/752 44/18639 0.0227272727272727 0.563316005802708 0.837022602335061 0.937794365269749 GO:0048306 calcium-dependent protein binding 2/752 80/18639 0.025 0.619647606382979 0.838791240849004 0.938123809829997 GO:0005525 GTP binding 12/752 378/18639 0.0317460317460317 0.786854103343465 0.83937393511105 0.938123809829997 GO:0008009 chemokine activity 1/752 45/18639 0.0222222222222222 0.550797872340426 0.843613567812019 0.938262894932392 GO:0042605 peptide antigen binding 1/752 45/18639 0.0222222222222222 0.550797872340426 0.843613567812019 0.938262894932392 GO:0051539 4 iron, 4 sulfur cluster binding 1/752 45/18639 0.0222222222222222 0.550797872340426 0.843613567812019 0.938262894932392 GO:0140303 intramembrane lipid transporter activity 1/752 45/18639 0.0222222222222222 0.550797872340426 0.843613567812019 0.938262894932392 GO:0015293 symporter activity 4/752 146/18639 0.0273972602739726 0.679065870008744 0.845370794884671 0.939072064476029 GO:0015085 calcium ion transmembrane transporter activity 4/752 147/18639 0.0272108843537415 0.674446374294399 0.849099819964895 0.939568188404514 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/752 46/18639 0.0217391304347826 0.538824005550416 0.849938328326452 0.939568188404514 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/752 46/18639 0.0217391304347826 0.538824005550416 0.849938328326452 0.939568188404514 GO:0030276 clathrin binding 1/752 46/18639 0.0217391304347826 0.538824005550416 0.849938328326452 0.939568188404514 GO:0005254 chloride channel activity 2/752 83/18639 0.0240963855421687 0.597250704947449 0.853465773104148 0.942325405654943 GO:0099095 ligand-gated monoatomic anion channel activity 1/752 47/18639 0.0212765957446809 0.52735966500679 0.856007621990654 0.943204101570385 GO:0008509 monoatomic anion transmembrane transporter activity 4/752 149/18639 0.0268456375838926 0.66539340282736 0.856330039583639 0.943204101570385 GO:0022853 active monoatomic ion transmembrane transporter activity 3/752 118/18639 0.0254237288135593 0.63015010818608 0.859997378296729 0.946100855255268 GO:0050660 flavin adenine dinucleotide binding 2/752 86/18639 0.0232558139534884 0.576416378030678 0.866912292242043 0.951970639544033 GO:0016763 pentosyltransferase activity 1/752 49/18639 0.0204081632653061 0.505834780720799 0.867420615637162 0.951970639544033 GO:0016741 transferase activity, transferring one-carbon groups 6/752 215/18639 0.027906976744186 0.691699653636814 0.869765482789134 0.953396779211166 GO:0048020 CCR chemokine receptor binding 1/752 50/18639 0.02 0.495718085106383 0.872783697780295 0.955556701531368 GO:0015276 ligand-gated monoatomic ion channel activity 5/752 186/18639 0.0268817204301075 0.666287748798902 0.8747071928892 0.9565143404256 GO:0005048 signal sequence binding 1/752 51/18639 0.0196078431372549 0.485998122653317 0.87793011013541 0.956597682728188 GO:0016597 amino acid binding 1/752 51/18639 0.0196078431372549 0.485998122653317 0.87793011013541 0.956597682728188 GO:0030544 Hsp70 protein binding 1/752 51/18639 0.0196078431372549 0.485998122653317 0.87793011013541 0.956597682728188 GO:0140104 molecular carrier activity 7/752 249/18639 0.0281124497991968 0.696792489105358 0.879499258294663 0.956982083456541 GO:0022834 ligand-gated channel activity 5/752 188/18639 0.0265957446808511 0.659199581258488 0.880381543881621 0.956982083456541 GO:0005267 potassium channel activity 3/752 124/18639 0.0241935483870968 0.599658973919012 0.88155337000877 0.957115087438093 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/752 52/18639 0.0192307692307692 0.476652004909984 0.882868595027715 0.957403280220304 GO:0005544 calcium-dependent phospholipid binding 1/752 53/18639 0.0188679245283019 0.467658570855078 0.887607542493102 0.959120946390651 GO:0016860 intramolecular oxidoreductase activity 1/752 53/18639 0.0188679245283019 0.467658570855078 0.887607542493102 0.959120946390651 GO:0034212 protein N-acetyltransferase activity 1/752 53/18639 0.0188679245283019 0.467658570855078 0.887607542493102 0.959120946390651 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/752 54/18639 0.0185185185185185 0.458998226950355 0.892155004456149 0.961755749484643 GO:0050661 NADP binding 1/752 54/18639 0.0185185185185185 0.458998226950355 0.892155004456149 0.961755749484643 GO:0022836 gated channel activity 9/752 318/18639 0.0283018867924528 0.701487856282617 0.898986194973859 0.967975690455915 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/752 130/18639 0.0230769230769231 0.57198240589198 0.900104771487511 0.968037207071475 GO:0016407 acetyltransferase activity 2/752 96/18639 0.0208333333333333 0.516373005319149 0.90395201700903 0.970123481368206 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/752 229/18639 0.0262008733624454 0.649412338567314 0.904172104345367 0.970123481368206 GO:0008408 3'-5' exonuclease activity 1/752 58/18639 0.0172413793103448 0.427343176815847 0.908579948795302 0.970125858585098 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/752 58/18639 0.0172413793103448 0.427343176815847 0.908579948795302 0.970125858585098 GO:0061980 regulatory RNA binding 1/752 58/18639 0.0172413793103448 0.427343176815847 0.908579948795302 0.970125858585098 GO:0005249 voltage-gated potassium channel activity 2/752 98/18639 0.0204081632653061 0.505834780720799 0.910098663420141 0.970125858585098 GO:0030527 structural constituent of chromatin 2/752 98/18639 0.0204081632653061 0.505834780720799 0.910098663420141 0.970125858585098 GO:0015459 potassium channel regulator activity 1/752 59/18639 0.0169491525423729 0.420100072124053 0.912279850765375 0.970125858585098 GO:0036002 pre-mRNA binding 1/752 59/18639 0.0169491525423729 0.420100072124053 0.912279850765375 0.970125858585098 GO:0001098 basal transcription machinery binding 1/752 60/18639 0.0166666666666667 0.413098404255319 0.915830203414699 0.970125858585098 GO:0001099 basal RNA polymerase II transcription machinery binding 1/752 60/18639 0.0166666666666667 0.413098404255319 0.915830203414699 0.970125858585098 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/752 60/18639 0.0166666666666667 0.413098404255319 0.915830203414699 0.970125858585098 GO:0043130 ubiquitin binding 2/752 100/18639 0.02 0.495718085106383 0.915875399387905 0.970125858585098 GO:0005216 monoatomic ion channel activity 13/752 448/18639 0.0290178571428571 0.719233828837386 0.918051074142711 0.970305768427923 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7/752 268/18639 0.0261194029850746 0.647393021594157 0.919231458034996 0.970305768427923 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/752 61/18639 0.0163934426229508 0.406326299267527 0.919237043773822 0.970305768427923 GO:0046873 metal ion transmembrane transporter activity 13/752 450/18639 0.0288888888888889 0.716037234042553 0.920815565256091 0.970723536001237 GO:0015179 L-amino acid transmembrane transporter activity 1/752 62/18639 0.0161290322580645 0.399772649279341 0.92250616548133 0.970723536001237 GO:0140101 catalytic activity, acting on a tRNA 3/752 139/18639 0.0215827338129496 0.534947573855809 0.923047438477635 0.970723536001237 GO:0005253 monoatomic anion channel activity 2/752 103/18639 0.0194174757281553 0.481279694278042 0.923890382948546 0.970723536001237 GO:0004536 DNA nuclease activity 1/752 64/18639 0.015625 0.387279753989362 0.928653268942774 0.973224708649122 GO:0004497 monooxygenase activity 2/752 106/18639 0.0188679245283019 0.467658570855078 0.931181681485714 0.973224708649122 GO:0019843 rRNA binding 1/752 65/18639 0.0153846153846154 0.381321603927987 0.931541707260676 0.973224708649122 GO:0160215 deacylase activity 1/752 65/18639 0.0153846153846154 0.381321603927987 0.931541707260676 0.973224708649122 GO:0022843 voltage-gated monoatomic cation channel activity 3/752 143/18639 0.020979020979021 0.519984005356346 0.931606546766101 0.973224708649122 GO:0001217 DNA-binding transcription repressor activity 7/752 278/18639 0.0251798561151079 0.624105502831777 0.935175940557818 0.975414687813114 GO:0005261 monoatomic cation channel activity 9/752 341/18639 0.0263929618768328 0.654173426093467 0.935841942803153 0.975414687813114 GO:0003777 microtubule motor activity 1/752 68/18639 0.0147058823529412 0.364498591989988 0.939524969162184 0.977020264396707 GO:1990841 promoter-specific chromatin binding 1/752 68/18639 0.0147058823529412 0.364498591989988 0.939524969162184 0.977020264396707 GO:0002039 p53 binding 1/752 69/18639 0.0144927536231884 0.359216003700278 0.941973799230034 0.978451144530514 GO:0008234 cysteine-type peptidase activity 4/752 187/18639 0.0213903743315508 0.530179770167254 0.946871558687333 0.98241963768242 GO:0042379 chemokine receptor binding 1/752 72/18639 0.0138888888888889 0.344248670212766 0.948741920828903 0.983241627040863 GO:0044183 protein folding chaperone 1/752 75/18639 0.0133333333333333 0.330478723404255 0.95472154149025 0.988307927247667 GO:0051536 iron-sulfur cluster binding 1/752 76/18639 0.0131578947368421 0.326130319148936 0.956555704429236 0.988307927247667 GO:0051540 metal cluster binding 1/752 77/18639 0.012987012987013 0.32189486045869 0.958315662963374 0.988307927247667 GO:0004540 RNA nuclease activity 2/752 121/18639 0.0165289256198347 0.409684367856515 0.958732267790581 0.988307927247667 GO:0015079 potassium ion transmembrane transporter activity 3/752 160/18639 0.01875 0.464735704787234 0.95905675624139 0.988307927247667 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 2/752 122/18639 0.0163934426229508 0.406326299267527 0.960132481953326 0.988307927247667 GO:0004519 endonuclease activity 2/752 127/18639 0.015748031496063 0.390329200871168 0.966476728845157 0.991628403713485 GO:0019783 ubiquitin-like protein peptidase activity 2/752 127/18639 0.015748031496063 0.390329200871168 0.966476728845157 0.991628403713485 GO:0008135 translation factor activity, RNA binding 1/752 83/18639 0.0120481927710843 0.298625352473725 0.967476821407354 0.991628403713485 GO:0004527 exonuclease activity 1/752 84/18639 0.0119047619047619 0.295070288753799 0.968794854943767 0.991628403713485 GO:0180051 translation factor activity 1/752 84/18639 0.0119047619047619 0.295070288753799 0.968794854943767 0.991628403713485 GO:0005244 voltage-gated monoatomic ion channel activity 3/752 173/18639 0.0173410404624277 0.429813368589349 0.972664632974573 0.993950051166657 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/752 88/18639 0.0113636363636364 0.281658002901354 0.973554656917223 0.993950051166657 GO:0022832 voltage-gated channel activity 3/752 175/18639 0.0171428571428571 0.424901215805471 0.974332615946262 0.993950051166657 GO:0140098 catalytic activity, acting on RNA 9/752 387/18639 0.0232558139534884 0.576416378030678 0.976197960113987 0.994740267736263 GO:0016853 isomerase activity 3/752 180/18639 0.0166666666666667 0.413098404255319 0.978090121588137 0.995556016616497 GO:0004867 serine-type endopeptidase inhibitor activity 1/752 95/18639 0.0105263157894737 0.260904255319149 0.980206327829564 0.996395585062972 GO:0015078 proton transmembrane transporter activity 3/752 185/18639 0.0162162162162162 0.401933582518689 0.981320293537197 0.996395585062972 GO:0003730 mRNA 3'-UTR binding 5/752 262/18639 0.0190839694656489 0.473013439987007 0.982192577819749 0.996395585062972 GO:0005125 cytokine activity 4/752 234/18639 0.0170940170940171 0.423690671031097 0.986337447692289 0.999114033637788 GO:0004843 cysteine-type deubiquitinase activity 1/752 108/18639 0.00925925925925926 0.229499113475177 0.988446150791942 0.999114033637788 GO:0022804 active transmembrane transporter activity 10/752 457/18639 0.0218818380743982 0.542361143442432 0.98984068888693 0.999114033637788 GO:0015291 secondary active transmembrane transporter activity 5/752 287/18639 0.0174216027874564 0.431810178664097 0.991246725979286 0.999114033637788 GO:0101005 deubiquitinase activity 1/752 115/18639 0.00869565217391304 0.215529602220167 0.991354996160733 0.999114033637788 GO:0004518 nuclease activity 3/752 209/18639 0.0143540669856459 0.355778529980658 0.991445395221709 0.999114033637788 GO:0051082 unfolded protein binding 1/752 121/18639 0.00826446280991736 0.204842183928257 0.993258454029876 0.999658909411827 GO:0004252 serine-type endopeptidase activity 2/752 176/18639 0.0113636363636364 0.281658002901354 0.994178323285666 0.999658909411827 GO:0008236 serine-type peptidase activity 2/752 194/18639 0.0103092783505155 0.255524786137311 0.996995789264649 0.999950799945009 GO:0017171 serine hydrolase activity 2/752 198/18639 0.0101010101010101 0.250362669245648 0.997409301719825 0.999950799945009 GO:0003823 antigen binding 1/752 174/18639 0.00574712643678161 0.142447725605282 0.999253285564632 0.999950799945009 GO:0003735 structural constituent of ribosome 1/752 175/18639 0.00571428571428571 0.141633738601824 0.99928369603067 0.999950799945009 GO:0045182 translation regulator activity 3/752 356/18639 0.00842696629213483 0.208869979679656 0.999950799945009 0.999950799945009