category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	13/102	82/9376	14.5729316116691	HLA-DRB1/HSP90AA1/HLA-DRB3/HSP90AB1/HSPA4/IFI30/HSPA8/HLA-E/HLA-G/CTSB/HLA-DRA/TAPBP/HLA-DPA1	12.9458756545061
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	15/102	224/9376	6.15546218487395	HLA-DRB1/HLA-DRB3/ZFP36/JUN/HLA-E/HLA-G/MSX2/HLA-DRA/CDKN1A/ATF4/NFKBIA/CCNE1/GPS2/HLA-DPA1/NFKB2	8.19003556005742
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/102	109/9376	9.27648857708221	HLA-DRB1/HSP90AA1/HLA-DRB3/HSP90AB1/JUN/HLA-DRA/NFKBIA/HLA-DPA1/EBI3/AHR/NFKBIE	9.11469132876518
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/102	205/9376	6.27757054041129	HLA-DRB1/PLCG2/HLA-DRB3/JUN/HLA-E/HLA-G/HLA-DRA/CDKN1A/NFKBIA/CCNE1/TAPBP/HLA-DPA1/NFKB2/NFKBIE	8.01225585110483
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/102	44/9376	14.6238859180036	HLA-DRB1/HLA-DRB3/HSPD1/HLA-E/HLA-G/HLA-DRA/HLA-DPA1	9.49931195025271
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/102	205/9376	5.38077474892396	JUN/REL/CHD4/HLA-E/YWHAE/HLA-G/CDKN1A/ATF4/NFKBIA/CCNE1/NFKB2/EGR3	6.65076626558987
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/102	39/9376	14.1417797888386	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/HLA-DPA1	8.62452108030013
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/102	45/9376	12.2562091503268	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/HLA-DPA1	7.93755037554096
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/102	70/9376	9.1921568627451	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/CD55/HLA-DPA1	7.21469429668436
Human Diseases	Immune disease	hsa05310	Asthma	5/102	32/9376	14.3627450980392	HLA-DRB1/HLA-DRB3/PRG2/HLA-DRA/HLA-DPA1	7.94065699552228
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/102	54/9376	10.2135076252723	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/HLA-DPA1	7.12064785256633
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/102	110/9376	6.68520499108734	PLCG2/FLT1/MKNK2/EPAS1/LDHA/CDKN1A/SERPINE1/GAPDH	6.28996894994751
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/102	180/9376	5.10675381263617	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/BIRC3/NFKBIA/TAPBP/HLA-DPA1/CGAS	5.83428470886172
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/102	93/9376	6.91882774615222	HLA-DRB1/HLA-DRB3/JUN/HLA-DRA/NFKBIA/HLA-DPA1/NFKBIE	6.01568626325534
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/102	95/9376	6.77316821465428	HLA-DRB1/HLA-DRB3/FLT1/JUN/CCL3/HLA-DRA/HLA-DPA1	5.93103936450868
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/102	216/9376	4.2556281771968	HSP90AA1/HSPD1/HSP90AB1/HSPA4/JUN/CCL3/HSPA8/ATF4/NFKBIA/OLR1	5.07652016522493
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/102	105/9376	6.1281045751634	PLCG2/JUN/PLK3/NFKBIA/NFKB2/LSP1/EGR3	5.54166680725996
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/102	78/9376	7.07088989441931	HLA-DRB1/HLA-DRB3/JUN/HLA-DRA/NFKBIA/HLA-DPA1	5.6462104960676
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/102	50/9376	9.1921568627451	HLA-DRB1/HLA-DRB3/HLA-DRA/HLA-DPA1/TNFRSF13B	6.09098786771142
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/102	112/9376	5.74509803921569	HLA-DRB1/HLA-DRB3/HSPA8/HLA-DRA/BIRC3/NFKBIA/HLA-DPA1	5.29794086357394
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	10/102	238/9376	3.86225078266601	PLCG2/JUN/RPS10/RPL36A/RPS9/RPS18/NFKBIA/RPS17/RPL7A/CGAS	4.69053912382098
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/102	155/9376	4.74433902593295	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/HLA-DPA1/OLR1/TUBB4B	4.92951486767512
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/102	300/9376	3.37045751633987	FLT1/NR4A1/MKNK2/JUN/JUND/DUSP9/DUSP2/HSPA8/HSPB1/ATF4/NFKB2	4.37620580912481
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/102	93/9376	5.93042378241619	FN1/CKS2/CDKN1A/BIRC3/NFKBIA/CCNE1	5.01110758615845
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/102	94/9376	5.86733416770964	HSP90AA1/HSP90AB1/FOSB/JUN/JUND/NFKBIA	4.97377902913114
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/102	362/9376	3.04712382190445	HSP90AA1/HSP90AB1/FN1/FLT1/NR4A1/SPP1/MCL1/CSH1/YWHAE/CDKN1A/ATF4/CCNE1	4.16573653105484
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/102	137/9376	4.69672248461428	LMNA/JUN/MCL1/CTSB/BIRC3/ATF4/NFKBIA	4.57105900481419
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/102	66/9376	6.96375519904932	HLA-DRB1/HLA-DRB3/JUN/HLA-DRA/HLA-DPA1	5.09881334439164
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/102	142/9376	4.53134493233913	PLCG2/FOSB/JUN/JUND/SQSTM1/NFKBIA/NFKB2	4.44673814331268
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/102	106/9376	5.2031076581576	HSP90AA1/HSP90AB1/CDKN1A/ATF4/NFKBIA/CCNE1	4.56389619599195
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/102	120/9376	4.59607843137255	PLCG2/JUN/YWHAE/ATF4/NFKBIA/NFKBIE	4.15776829858877
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/102	214/9376	3.43632032252153	PLCG2/JUN/HLA-E/HLA-G/NFKBIA/TAPBP/CGAS/WEE1	3.78092714633481
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/102	174/9376	3.69799414018481	HSP90AA1/HSPH1/HSP90AB1/DNAJA1/DNAJB1/HSPA8/ATF4	3.76726950457911
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/102	56/9376	6.56582633053221	HSPD1/HSPA8/NFKBIA/NFKB2	4.38094586455366
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/102	227/9376	3.23952664766347	CCL3/HLA-E/HLA-G/CDKN1A/ATF4/NFKBIA/TAPBP/CGAS	3.5820737859371
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/102	181/9376	3.55497779222186	HLA-DRB1/HLA-DRB3/HSPD1/PLK3/HLA-DRA/HLA-DPA1/LSP1	3.64001127229302
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/102	139/9376	3.96783749471011	HSP90AA1/HSP90AB1/JUN/HSPA8/ATF4/KRT19	3.69687038268056
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/102	187/9376	3.4409143336479	HSP90AA1/HSP90AB1/JUN/YWHAE/CTSB/BIRC3/NFKBIA	3.53583013996016
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/102	99/9376	4.64250346603288	HLA-DRB1/HLA-DRB3/HLA-DRA/HLA-DPA1/KRT19	3.82090263452503
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/102	100/9376	4.59607843137255	HLA-DRB1/HLA-DRB3/HLA-DRA/CD55/HLA-DPA1	3.79141185369711
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	7/102	196/9376	3.28291316526611	PLCG2/ZFP36/JUN/HLA-E/HLA-G/CDKN1A/NFKBIA	3.3872579129997
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/102	248/9376	2.9652118912081	HSP90AA1/HSP90AB1/JUN/AHNAK/BIRC3/NFKBIA/GAPDH/TUBB4B	3.2892704717539
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/102	157/9376	3.51292618958411	SQSTM1/HLA-E/HLA-G/CDKN1A/SERPINE1/CCNE1	3.32996623251752
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/102	160/9376	3.44705882352941	HLA-DRB1/HLA-DRB3/HLA-E/HLA-G/HLA-DRA/HLA-DPA1	3.27405028901598
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/102	163/9376	3.38361602309636	JUN/CDKN1A/ATF4/NFKBIA/CCNE1/EGR3	3.21945041857506
Genetic Information Processing	Translation	hsa03010	Ribosome	7/102	222/9376	2.89842783960431	RPS10/RPL36A/RPS9/RPS18/MRPL18/RPS17/RPL7A	3.00204574334845
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/102	173/9376	3.18803128187691	HLA-DRB1/HLA-DRB3/DNAJB1/HLA-DRA/NFKBIA/HLA-DPA1	3.04623950244
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/102	49/9376	5.62785114045618	FOSB/JUN/ATF4	3.40610954167689
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/102	91/9376	4.04050851109675	PLCG2/JUN/NFKBIA/NFKBIE	3.05652634800153
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/102	101/9376	3.64045816346341	PLCG2/FN1/JUN/SERPINE1	2.79791938208645
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/102	103/9376	3.56976965543499	JUN/CCL3/SERPINE1/NFKBIA	2.75014034509238
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/102	155/9376	2.9652118912081	NR4A1/CDKN1A/ATF4/CCNE1/AHR	2.58725002430261
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/102	105/9376	3.50177404295051	PLCG2/BIRC3/NFKBIA/NFKB2	2.70353265419546
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/102	217/9376	2.54161019246408	HSP90AA1/HSP90AB1/JUN/PTGES3/ATF4/AHR	2.40953139181226
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/102	109/9376	3.37326857348444	SPP1/JUN/CCL3/NFKBIA	2.6136217414071
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/102	69/9376	3.99658994032396	FOSB/JUN/ATF4	2.61998728676851
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/102	70/9376	3.93949579831933	JUN/EPAS1/CDKN1A	2.58876434211194
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/102	119/9376	3.08980062613281	JUN/BIRC3/ATF4/NFKBIA	2.40599866536086
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/102	71/9376	3.88400994200497	PLCG2/JUN/NFKBIA	2.5581141331531
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/102	75/9376	3.67686274509804	CDKN1A/SERPINE1/CCNE1	2.44086686205898
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/102	78/9376	3.53544494720965	HSPD1/TOB2/PABPC4	2.35808194879246
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/102	136/9376	2.70357554786621	JUN/HSPA8/NFKBIA/CCNE1	2.09868396697019
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/102	86/9376	3.20656634746922	PLCG2/JUN/CDKN1A	2.1558102741762
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/102	201/9376	2.28660618476246	FLT1/REL/CDKN1A/BIRC3/FUS	1.93371651023693
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/102	142/9376	2.58933996133665	HSP90AA1/HSP90AB1/JUN/SQSTM1	2.00132775590557
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/102	203/9376	2.26407804501111	FN1/FLT1/SPP1/JUN/BIRC3	1.90949439936401
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/102	143/9376	2.57123268887975	HLA-DRB1/HLA-DRB3/HLA-DRA/HLA-DPA1	1.98558866583716
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	7/102	333/9376	1.93228522640287	FN1/SPP1/CHD4/HLA-E/HLA-G/CDKN1A/CCNE1	1.81663146363262
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/102	88/9376	3.13368983957219	SERPINE2/CD55/SERPINE1	2.10893745573719
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/102	90/9376	3.0640522875817	JUN/NFKBIA/NFKBIE	2.06338271539546
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/102	158/9376	2.3271283196823	YWHAE/CDKN1A/CCNE1/WEE1	1.76431158807425
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/102	105/9376	2.62633053221289	JUN/SQSTM1/ATF4	1.7574879365073
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/102	52/9376	3.53544494720965	PLTP/APOC2	1.92267953070872
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/102	168/9376	2.18860877684407	HSP90AA1/HSP90AB1/SQSTM1/BIRC3	1.63028336325275
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/102	55/9376	3.34260249554367	PSAP/HEXB	1.82726220193038
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/102	115/9376	2.39795396419437	JUND/CDKN1A/ATF4	1.58184900743451
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/102	60/9376	3.0640522875817	PLCG2/HSPB1	1.68203008127981
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/102	253/9376	1.81663179105634	PLCG2/JUN/SQSTM1/NFKBIA/CGAS	1.38092433915045
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/102	122/9376	2.26036644165863	JUN/NFKBIA/NFKBIE	1.46948168387931
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/102	122/9376	2.26036644165863	PLCG2/CSH1/ATF4	1.46948168387931
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/102	15/9376	6.1281045751634	HEXB	2.08445996442537
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/102	65/9376	2.82835595776772	NR4A1/ATF4	1.55121303164609
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/102	16/9376	5.74509803921569	MIF	1.99213807078241
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/102	16/9376	5.74509803921569	HEXB	1.99213807078241
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/102	67/9376	2.74392742171495	LDHA/GAPDH	1.50233391370624
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/102	130/9376	2.12126696832579	JUN/ATF4/NFKBIA	1.35006891624363
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/102	200/9376	1.83843137254902	JUN/NFKBIA/GAPDH/TUBB4B	1.25692103432085
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/102	133/9376	2.0734188412207	PLCG2/HLA-E/HLA-G	1.30749710592506
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/102	70/9376	2.62633053221289	NFKBIA/NFKBIE	1.43228185346883
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/102	18/9376	5.10675381263617	HEXB	1.82892366504721
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/102	275/9376	1.67130124777184	STIP1/HSPA8/ATF4/TUBB4B/MT-CO1	1.18492652782647
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	4/102	204/9376	1.80238369857747	PLCG2/FN1/CDKN1A/TIMP3	1.21511487074613
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/102	19/9376	4.83797729618163	HEXB	1.75615589292625
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/102	73/9376	2.51839914047811	PLCG2/CDKN1A	1.36580295222548
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/102	138/9376	1.99829497016198	FN1/JUN/NFKBIA	1.23897238171707
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/102	75/9376	2.45124183006536	CDKN1A/BIRC3	1.32329836422399
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/102	76/9376	2.41898864809082	OLR1/PLTP	1.30255605262995
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/102	76/9376	2.41898864809082	PLCG2/CDKN1A	1.30255605262995
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/102	77/9376	2.38757321110262	CDKN1A/NFKBIA	1.28213962865933
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	6/102	368/9376	1.49872122762148	SQSTM1/HNRNPA2B1/ATF4/TUBB4B/MT-CO1/FUS	1.02357519515133
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/102	22/9376	4.17825311942959	AOC1	1.56514045796367
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/102	148/9376	1.86327503974563	JUN/CDKN1A/NFKB2	1.1101417279979
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/102	83/9376	2.21497755728798	NFKBIA/CGAS	1.16595425525557
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	4/102	227/9376	1.61976332383174	JUN/NFKBIA/MT-CO1/AHR	0.991297852204215
NA	NA	hsa04518	Integrin signaling	3/102	154/9376	1.79067990832697	FN1/FLT1/SPP1	1.03753004755154
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/102	156/9376	1.76772247360483	YWHAE/CDKN1A/NFKBIA	1.01403576048725
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/102	157/9376	1.75646309479206	YWHAE/SERPINE1/BIRC3	1.0024156587823
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/102	157/9376	1.75646309479206	JUN/ATF4/MT-CO1	1.0024156587823
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/102	87/9376	2.11313950867703	JUN/CDKN1A	1.09389823251869
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/102	26/9376	3.53544494720965	MAFA	1.35764814914242
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/102	89/9376	2.06565322758317	FN1/SPP1	1.0593155891019
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/102	93/9376	1.97680792747206	JUN/ATF4	0.992792877770882
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/102	243/9376	1.51311224078109	HNRNPU/HSPA8/RBM25/FUS	0.849886560289329
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/102	323/9376	1.42293449887695	PLCG2/MCL1/CDKN1A/TIMP3/CCNE1	0.811204388350533
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/102	168/9376	1.64145658263305	MCL1/CSH1/CDKN1A	0.879815137906236
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/102	98/9376	1.87595038015206	NR4A1/ATF4	0.914150155552429
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/102	250/9376	1.47074509803922	HSPA8/ACAP1/HLA-E/HLA-G	0.791166257511609
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/102	99/9376	1.85700138641315	JUN/CDKN1A	0.898974808307858
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/102	32/9376	2.87254901960784	LDHA	1.11274063546937
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/102	32/9376	2.87254901960784	BIRC3	1.11274063546937
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/102	178/9376	1.54923992068738	NOTUM/CACYBP/JUN	0.775849657230773
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/102	103/9376	1.78488482771749	PABPC4/FUS	0.839975453205119
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/102	103/9376	1.78488482771749	FN1/HSPB1	0.839975453205119
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/102	34/9376	2.70357554786621	BHLHE40	1.04359767573131
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/102	107/9376	1.71816016126077	LDHA/ATF4	0.783517923612308
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/102	37/9376	2.48436671966084	MIF	0.948733118583049
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/102	37/9376	2.48436671966084	HBA2	0.948733118583049
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/102	37/9376	2.48436671966084	CDKN1A	0.948733118583049
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/102	110/9376	1.67130124777184	HSP90AA1/HSP90AB1	0.742710950821544
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/102	38/9376	2.41898864809082	HEXB	0.919170257321039
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/102	38/9376	2.41898864809082	TNFRSF13B	0.919170257321039
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/102	193/9376	1.42883267296556	PLCG2/CCL3/NFKBIA	0.631286362800444
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/102	41/9376	2.24198947871832	CDKN1A	0.835804802647989
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/102	42/9376	2.18860877684407	AOC1	0.809621174580506
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/102	44/9376	2.0891265597148	HEXB	0.75939808996525
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/102	47/9376	1.95577805590321	LDHA	0.688875304316203
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/102	47/9376	1.95577805590321	MAFA	0.688875304316203
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/102	298/9376	1.23384655875773	CSH1/CCL3/EBI3/TNFRSF13B	0.430225555913986
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/102	50/9376	1.83843137254902	AOC1	0.623385929208569
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/102	50/9376	1.83843137254902	HBA2	0.623385929208569
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/102	133/9376	1.38227922748047	PLK3/CDKN1A	0.46564208153601
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/102	51/9376	1.80238369857747	PLCG2	0.602552569778301
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/102	138/9376	1.33219664677465	YWHAE/CCNE1	0.412285429612085
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/102	54/9376	1.70225127087872	LDHA	0.542734016980503
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/102	140/9376	1.31316526610644	SPP1/SERPINE1	0.391514473296619
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/102	142/9376	1.29466998066832	BIRC3/HERC2	0.371054164300824
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/102	59/9376	1.55799268860086	CDKN1A	0.450887966458403
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/102	238/9376	1.1586752347998	PLCG2/FLT1/REL	0.260030463199563
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/102	150/9376	1.22562091503268	CDKN1A/CCNE1	0.292126152587564
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/102	62/9376	1.48260594560405	HSPA8	0.399827419755143
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/102	63/9376	1.45907251789605	PTGES3	0.383406036507734
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/102	63/9376	1.45907251789605	CDKN1A	0.383406036507734
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/102	154/9376	1.19378660555131	JUN/CDKN1A	0.254286752395079
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/102	65/9376	1.41417797888386	SPP1	0.351396715467757
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/102	250/9376	1.10305882352941	CTSB/PSAP/HEXB	0.173207674503541
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/102	67/9376	1.37196371085748	ATF4	0.320434033280857
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/102	254/9376	1.08568781843446	PLCG2/FLT1/P2RX5	0.145192134092241
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/102	69/9376	1.33219664677465	PLCG2	0.290447144450677
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/102	69/9376	1.33219664677465	CTSB	0.290447144450677
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/102	71/9376	1.29466998066832	LDHA	0.261371998474993
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/102	72/9376	1.27668845315904	NFKBIA	0.24715796518506
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/102	73/9376	1.25919957023905	CDKN1A	0.233150512806932
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/102	169/9376	1.08782921452605	SQSTM1/CTSB	0.120830189840551
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/102	170/9376	1.08143021914648	HSPA4/JUN	0.112363887766745
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/102	170/9376	1.08143021914648	PLCG2/CDKN1A	0.112363887766745
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/102	75/9376	1.22562091503268	GAPDH	0.205729866388993
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/102	75/9376	1.22562091503268	ATF4	0.205729866388993
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	3/102	268/9376	1.02897278314311	ATF4/TUBB4B/MT-CO1	0.0504659299049161
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/102	77/9376	1.19378660555131	CDKN1A	0.179061893450129
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/102	78/9376	1.17848164906988	PLCG2	0.165996250609027
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/102	78/9376	1.17848164906988	FN1	0.165996250609027
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/102	78/9376	1.17848164906988	JUN	0.165996250609027
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/102	80/9376	1.14901960784314	PLCG2	0.140375892488603
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/102	83/9376	1.10748877864399	RYBP	0.103151698646954
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/102	184/9376	0.999147485080989	PLCG2/SEMA7A	-0.00122477995458916
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/102	480/9376	0.957516339869281	SQSTM1/ATF4/TUBB4B/MT-CO1/FUS	-0.10020683278399
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/102	86/9376	1.06885544915641	ATF4	0.0672716163258124
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/102	86/9376	1.06885544915641	LMNA	0.0672716163258124
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/102	388/9376	0.947645037396402	ATF4/GAPDH/TUBB4B/MT-CO1	-0.110457284675354
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/102	87/9376	1.05656975433852	MT-CO1	0.0555919126062345
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/102	191/9376	0.96252951442357	FOSB/ATF4	-0.0548679333882008
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/102	89/9376	1.03282661379158	TUBB4B	0.0326313877974329
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/102	90/9376	1.02135076252723	ATF4	0.0213438364058217
NA	NA	hsa04519	Cadherin signaling	4/102	404/9376	0.910114540865851	KRT7/YWHAE/NFKBIA/KRT19	-0.193681290226713
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	2/102	205/9376	0.896795791487327	GAPDH/MT-CO1	-0.156681661984923
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/102	98/9376	0.93797519007603	PLCG2	-0.0647296820971341
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/102	98/9376	0.93797519007603	PLCG2	-0.0647296820971341
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/102	99/9376	0.928500693206576	PLCG2	-0.0750011337645336
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/102	99/9376	0.928500693206576	JUN	-0.0750011337645336
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/102	99/9376	0.928500693206576	LMNA	-0.0750011337645336
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/102	100/9376	0.91921568627451	CCL3	-0.085172392787525
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/102	103/9376	0.892442413858747	COL26A1	-0.115106992738514
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/102	105/9376	0.875443510737628	LMNA	-0.134601498869028
NA	NA	hsa04382	Cornified envelope formation	2/102	217/9376	0.847203397488028	KRT7/KRT19	-0.238820560550643
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/102	109/9376	0.84331714337111	NFKBIA	-0.172550938889228
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/102	226/9376	0.813465209092487	JUN/NFKBIA	-0.297684139017922
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/102	115/9376	0.799317988064791	ATF4	-0.227080897883939
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/102	116/9376	0.792427315753888	GAPDH	-0.235909744938634
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/102	116/9376	0.792427315753888	PLCG2	-0.235909744938634
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/102	117/9376	0.785654432713256	CHD4	-0.244668226385693
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	2/102	233/9376	0.789026340149794	FN1/LMNA	-0.341990479219892
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/102	122/9376	0.753455480552877	PLCG2	-0.287450255428572
Organismal Systems	Immune system	hsa04611	Platelet activation	1/102	126/9376	0.729536258948024	PLCG2	-0.32053513083388
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/102	133/9376	0.691139613740233	ATF4	-0.376212942853044
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/102	138/9376	0.666098323387326	MT-CO1	-0.4144015224929
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/102	138/9376	0.666098323387326	MKNK2	-0.4144015224929
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/102	144/9376	0.638344226579521	DUSP9	-0.458649504806076
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/102	144/9376	0.638344226579521	NFKBIA	-0.458649504806076
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/102	149/9376	0.616923279378866	PLCG2	-0.494311612486197
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/102	154/9376	0.596893302775656	ATF4	-0.528956542761379
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/102	157/9376	0.585487698264019	DUSP2	-0.549284723707849
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/102	166/9376	0.553744389321994	ATF4	-0.608359223184327
NA	NA	hsa04517	IgSF CAM signaling	2/102	299/9376	0.61485999081907	PLCG2/TUBB4B	-0.709798767926692
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/102	308/9376	0.596893302775656	TUBB4B/MT-CO1	-0.754382828712145
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/102	194/9376	0.473822518698201	TUBB4B	-0.776634460187284
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/102	195/9376	0.471392659627954	PLCG2	-0.782271809246498
NA	NA	hsa04082	Neuroactive ligand signaling	1/102	199/9376	0.461917430288698	P2RX5	-0.80459489861744
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/102	212/9376	0.433592304846467	FLT1	-0.874795848817745
NA	NA	hsa04081	Hormone signaling	1/102	219/9376	0.419733190079685	CSH1	-0.91122443932787
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/102	370/9376	0.496873343932167	P2RX5/CSH1	-1.03553407976593
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/102	232/9376	0.396213657876944	FN1	-0.976587917776663
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/102	235/9376	0.391155611180642	MT-CO1	-0.991278217087322