category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	26/715	109/9376	3.1279399499583	NFKBIA/IL1B/EBI3/HLA-DRB5/HSP90AA1/HLA-DQA2/IL2RB/HLA-DRA/HSP90AB1/CD247/GATA3/RORA/CD3D/IL2RG/CD3E/IFNG/HLA-DPA1/NFKB1/NFATC2/LCK/CD3G/HLA-DPB1/STAT1/PRKCQ/TBX21/IL23A	6.42033479437481
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	22/715	82/9376	3.51819887429644	CTSS/CD74/B2M/HSPA6/HLA-DRB5/HSP90AA1/KLRC1/CALR/CTSL/HLA-DQA2/HLA-DRA/HSP90AB1/KLRD1/HSPA8/IFI30/PDIA3/IFNG/HLA-DPA1/KLRC3/HSPA5/HLA-DPB1/TAPBP	6.58036914592978
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	24/715	100/9376	3.14718881118881	IL1B/CD59/CD7/HLA-DRB5/CD55/CD44/HLA-DQA2/HLA-DRA/IL7R/ITGA6/CSF3/CD37/CSF3R/CD3D/CD3E/CD2/HLA-DPA1/ITGA5/IL1A/CD3G/IL1R2/HLA-DPB1/IL3RA/CD34	6.20218198563652
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	32/715	160/9376	2.62265734265734	NEGR1/NCAM2/PTPRC/HLA-DRB5/VCAN/HLA-DQA2/ITGB1/JAM2/HLA-DRA/SELL/ITGA6/ITGB8/CLDN4/ICAM3/CLDN3/CD2/HLA-DPA1/CDH15/NRXN3/ICAM2/NRXN2/NCAM1/JAML/HLA-DPB1/CXADR/SPN/NLGN1/TIGIT/NEO1/ITGAL/CD34/CDH1	5.94798983184269
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	22/715	88/9376	3.27832167832168	SERPINE1/SERPINB2/CLU/PROCR/CD59/CD55/F2R/ITGAX/F10/C5AR1/C6/PLAU/A2M/VWF/C1S/VTN/SERPINA1/F5/PROS1/C3/CFH/PLAUR	6.16949923931682
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	22/715	93/9376	3.10206782464847	NFKBIA/HLA-DRB5/RUNX3/HLA-DQA2/IL2RB/HLA-DRA/CD247/GATA3/STAT4/CD3D/IL2RG/CD3E/IFNG/HLA-DPA1/NFKB1/NFATC2/LCK/CD3G/HLA-DPB1/STAT1/PRKCQ/TBX21	5.85327142643226
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	22/715	95/9376	3.03676113360324	CXCL8/CXCL2/IL1B/HLA-DRB5/IL15/CCL5/CTSL/HLA-DQA2/MMP1/HLA-DRA/ATP6V0E1/IFNG/HLA-DPA1/CCL20/CCL3L1/LTB/IL1A/CXCL3/HLA-DPB1/ATP6V0C/ITGAL/IL23A	5.73269920728826
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	31/715	174/9376	2.33627521903384	SSR4/CRYAB/HSP90B1/HSPA6/HSP90AA1/CALR/MAP3K5/DNAJA1/PDIA6/HSP90AB1/OSTC/HSPA8/SEC62/MARCHF6/SEC61B/PDIA3/TMEM258/P4HB/HSPH1/SSR3/SEC61G/PRKN/KRTCAP2/LMAN2/HSPA5/SELENOS/UBE2D1/DAD1/ERN1/HERPUD1/DNAJC1	5.11192018157321
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	44/715	298/9376	1.93618998451213	CXCL8/PRL/CXCL2/IL1B/XCL2/EBI3/XCL1/IL15/CCL5/IL32/IL2RB/IL7R/TNFSF10/CSF3/TNFRSF18/ACVRL1/CSF3R/TNFSF14/IL2RG/IFNG/CXCR4/GDF15/CCL20/CCL3L1/LTB/IL19/CX3CR1/IL1A/TNFRSF12A/CCR7/OSM/ACKR4/IL1R2/CXCL3/EDA/CXCR2/BMP8B/TNFSF9/BMP7/IL3RA/CXCL16/IL1RL1/IL23A/CSF2RB	4.71880111441409
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	20/715	94/9376	2.79006100282696	S100A8/S100A9/CXCL8/JUND/NFKBIA/TNFAIP3/CEBPB/CXCL2/IL1B/HSP90B1/HSP90AA1/FOSL1/MMP1/HSP90AB1/CSF3/PTGS2/IFNG/CCL20/NFKB1/CXCL3	5.01147555103594
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	16/715	66/9376	3.17897859716042	IL1B/HLA-DRB5/HLA-DQA2/HLA-DRA/GATA3/STAT4/RORA/IL2RG/IFNG/HLA-DPA1/NFKB1/IL1A/HLA-DPB1/STAT1/TBX21/IL23A	5.10393025956452
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/715	105/9376	2.62265734265734	CXCL8/NFKBIA/TNFAIP3/CXCL2/BCL2A1/IL1B/PLAU/PTGS2/TNFSF14/LTB/NFKB1/RELB/GADD45A/GADD45B/BIRC3/LCK/CARD11/CXCL3/EDA/PRKCQ/LYN	4.80410861965005
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/715	45/9376	3.49687645687646	GZMB/IL1B/HLA-DRB5/KLRC1/PRF1/HLA-DQA2/HLA-DRA/KLRD1/IFNG/HLA-DPA1/IL1A/HLA-DPB1	4.82385068453873
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	35/715	238/9376	1.92842451665981	CXCL8/NFKBIA/RPL39/RPL37/RPL34/RPLP1/RPL28/RPS21/RPL41/RPS28/IL1B/RPS4X/RPL12/RPS29/RPL36/RPL30/RPS11/RPS15A/MMP1/RPL35A/CSF3/C5AR1/FAU/RPS27/C6/NRP1/EGFR/VWF/ISG15/C1S/NFKB1/C3/STAT1/RPS26/RPL26L1	4.16834965328587
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/715	70/9376	2.80999000999001	ACTB/HLA-DRB5/CD55/PRF1/SSPN/HLA-DQA2/HLA-DRA/RAC2/SGCD/HLA-DPA1/DTNA/HLA-DPB1/CXADR/SNTB1/ITGAL	4.36715205652023
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/715	78/9376	2.68990496682804	NFKBIA/FCGR3B/IL1B/HLA-DRB5/HLA-DQA2/ITGB1/HLA-DRA/PTGS2/CYBA/IFNG/HLA-DPA1/NFKB1/IL1A/C3/HLA-DPB1/STAT1	4.30595466058153
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	23/715	138/9376	2.18554778554779	ATP5F1E/NDUFA4/MT-CO2/COX6C/MT-ND3/ATP6V0E1/NDUFS5/UQCRQ/COX7A2/COX6B1/COX7A1/UQCR11/NDUFA1/NDUFB1/NDUFA2/ATP5PF/COX7B/ATP5ME/UQCR10/NDUFB2/ATP6V0C/COX17/COX6A1	4.03110645853999
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/715	44/9376	3.27832167832168	GZMB/IL1B/HLA-DRB5/PRF1/HLA-DQA2/HLA-DRA/HSPD1/IFNG/HLA-DPA1/IL1A/HLA-DPB1	4.35219810469234
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/715	205/9376	1.91901756779806	VIM/NFKBIA/TNFAIP3/B2M/HLA-DRB5/CALR/RUNX3/CD44/HLA-DQA2/HLA-DRA/CD247/PDIA3/CD3D/CD3E/ISG15/HLA-DPA1/SEM1/NFKB1/RELB/GADD45A/MAP2K3/GADD45B/IRF7/CD3G/HLA-DPB1/ENTPD3/STAT1/LYN/ITGAL/TAPBP	3.82249597671168
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/715	275/9376	1.76433312142403	ATP5F1E/NDUFA4/MT-CO2/NCAM2/IL1B/HSPA6/TUBA4A/COX6C/CREB5/CCL5/MT-ND3/RAC2/HSPA8/PPIF/C6/NDUFS5/CYBA/UQCRQ/COX7A2/COX6B1/COX7A1/UQCR11/NCAM1/SEM1/NDUFA1/NDUFB1/HSPA5/IL1A/NDUFA2/ATP5PF/COX7B/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/COX6A1	3.69623103429875
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	18/715	100/9376	2.36039160839161	CXCL8/CXCL2/XCL2/XCL1/CCL5/IL2RB/TNFSF10/TNFSF14/IL2RG/CXCR4/CCL20/CCL3L1/IL19/CX3CR1/CCR7/ACKR4/CXCL3/CXCR2	3.92950833341297
NA	NA	hsa04517	IgSF CAM signaling	39/715	299/9376	1.71042870173305	ACTB/MYL6/NCAM2/TUBA4A/CD48/ITGAX/MYL12B/ITGB1/RAP1B/JAM2/CRTAM/NRP1/CD96/ICAM3/ARPC2/DYNLL1/ANK3/CD2/ICAM2/NCAM1/ARPC3/ITGA5/JAML/PAK5/LCK/PLXNA4/PAK3/CXADR/TUBA3E/NLGN1/PRKCQ/LYN/TUBA1C/LCP2/TIGIT/ARPC5L/SH2D1B/ITGAL/CDH1	3.58706763200407
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/715	155/9376	2.03044439431536	ACTB/CTSS/FCGR3B/TUBA4A/HLA-DRB5/CALR/CTSL/HLA-DQA2/ITGB1/HLA-DRA/ATP6V0E1/COLEC11/SEC61B/CORO1A/CYBA/HLA-DPA1/SEC61G/ITGA5/C3/HLA-DPB1/TUBA3E/ATP6V0C/TUBA1C/MRC2	3.71668743002367
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/715	137/9376	2.10578326782706	NFKBIA/ACTB/CTSS/CTSW/BCL2A1/GZMB/TUBA4A/CTSL/PRF1/MAP3K5/CTSH/TNFSF10/NFKB1/GADD45A/GADD45B/BIRC3/MCL1/ERN1/TUBA3E/TUBA1C/IL3RA/CSF2RB	3.74604037528594
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/715	112/9376	2.22457542457542	NFKBIA/HSPA6/HLA-DRB5/HLA-DQA2/ITGB1/HLA-DRA/ITGA6/HSPA8/PPIF/IFNG/HLA-DPA1/LAMA3/NFKB1/MAP2K3/BIRC3/LDLR/HLA-DPB1/STAT1/ALOX5	3.74584599033349
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	24/715	157/9376	2.00457886062982	CXCL8/NDUFA4/MT-CO2/IL1B/COX6C/MAP3K5/NDUFS5/UQCRQ/COX7A2/COX6B1/COX7A1/ADIPOR2/UQCR11/NFKB1/NDUFA1/NDUFB1/IL1A/IRS2/NDUFA2/COX7B/ERN1/UQCR10/NDUFB2/COX6A1	3.64709094851442
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/715	42/9376	3.12221112221112	FTH1/SAT1/FTL/GPX4/MAP1LC3B/CP/ACSL5/ACSL1/GSS/GCLC	3.96035368558027
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	35/715	268/9376	1.7125561006158	TXN/ATP5F1E/NDUFA4/MT-CO2/TUBA4A/UBC/COX6C/DUSP1/MT-ND3/MAP3K5/UCHL1/MAOB/PPIF/NDUFS5/UQCRQ/COX7A2/COX6B1/COX7A1/SNCAIP/UQCR11/SEM1/PRKN/NDUFA1/NDUFB1/HSPA5/NDUFA2/ATP5PF/COX7B/ERN1/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/COX6A1	3.40039671953621
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/715	99/9376	2.25177650632196	FCGR3B/HLA-DRB5/KRT24/HLA-DQA2/HLA-DRA/C5AR1/KRT10/KRT17/C1S/HLA-DPA1/KRT14/C3/CFH/FPR1/HLA-DPB1/KRT19/ITGAL	3.59745404754728
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/715	119/9376	2.09371804665922	NFKBIA/TNFAIP3/CEBPB/CXCL2/IL1B/IL15/CREB5/CCL5/MAP3K5/MAP3K8/PTGS2/IRF1/EDN1/CCL20/VEGFC/NFKB1/MAP2K3/BIRC3/CXCL3	3.44983534012021
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	31/715	235/9376	1.72983782175272	ACTB/ATP5F1E/NDUFA4/MT-CO2/COX6C/CREB5/MT-ND3/MAP3K5/NDUFS5/UQCRQ/COX7A2/COX6B1/COX7A1/UQCR11/NDUFA1/CNR1/NDUFB1/ACSL5/MAP2K3/NDUFA2/ATP5PF/COX7B/ATP5ME/NPR1/UQCR10/BMP8B/NDUFB2/CPT1C/ACSL1/COX17/COX6A1	3.25550286694844
NA	NA	hsa04382	Cornified envelope formation	29/715	217/9376	1.75246688795076	S100A8/S100A4/S100A6/S100A9/S100A11/S100A12/S100A10/KRT24/KRT6A/COL4A4/COL17A1/ITGA6/KRT86/SPRR3/KRT10/KRT81/CLDN4/KRT17/S100A16/KRT8/KRT5/PKP1/CLDN3/KRT14/LAMA3/S100A13/S100A3/KAZN/KRT19	3.22216570483947
Human Diseases	Immune disease	hsa05310	Asthma	8/715	32/9376	3.27832167832168	HLA-DRB5/PRG2/HLA-DQA2/HLA-DRA/HLA-DPA1/FCER1G/HLA-DPB1/MS4A2	3.70918296528125
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/715	133/9376	1.97192281402808	GZMB/FCGR3B/CD48/KLRC1/TYROBP/PRF1/RAC2/KLRD1/TNFSF10/HCST/CD247/IFNG/ICAM2/KLRC3/NFATC2/LCK/FCER1G/LCP2/SH2D1B/ITGAL	3.24343919239653
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/715	181/9376	1.81122744658656	CTSS/CEBPB/FCGR3B/CD74/IL1B/HLA-DRB5/ITGAX/HLA-DQA2/HLA-DRA/HSPD1/CORO1A/IFNG/HLA-DPA1/SPHK1/NFKB1/IL1A/C3/CLEC4E/FCER1G/HLA-DPB1/RIPK2/STAT1/ATP6V0C/MRC2/IL23A	3.16636295865698
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/715	193/9376	1.76655675930287	CXCL8/NFKBIA/CXCL2/XCL2/XCL1/CCL5/RAP1B/RAC2/GNGT1/GNG5/CXCR4/FGR/CCL20/CCL3L1/NFKB1/CX3CR1/RASGRP2/TIAM1/CCR7/GNG4/ITK/CXCL3/CXCR2/STAT1/LYN/CXCL16	3.0916143869647
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/715	90/9376	2.18554778554779	NFKBIA/CD247/EGFR/CD3D/CD3E/IFNG/RASGRP1/NFKB1/NFATC2/MAP2K3/LCK/CD3G/ALK/STAT1/PRKCQ	3.24698751341042
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	28/715	216/9376	1.6998704998705	CXCL8/NFKBIA/SOD2/CXCL2/IL1B/HSP90B1/HSPA6/HSP90AA1/CCL5/MAP3K5/MMP1/RAP1B/HSP90AB1/TNFSF10/HSPD1/HSPA8/CYBA/CCL3L1/NFKB1/NFATC2/HSPA5/MAP2K3/APOA1/IRF7/CXCL3/LDLR/ERN1/LYN	2.98986422409663
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	29/715	227/9376	1.67526570345954	NFKBIA/MGST1/SOD2/ATP5F1E/NDUFA4/MT-CO2/COX6C/MT-ND3/MAP3K5/PPIF/EGFR/NDUFS5/CYBA/UQCRQ/GSTM5/COX7A2/COX6B1/COX7A1/GSTA1/UQCR11/NFKB1/NDUFA1/NDUFB1/NDUFA2/ATP5PF/COX7B/UQCR10/NDUFB2/COX6A1	2.95907141862031
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/715	122/9376	1.93474721999312	NFKBIA/PTPRC/MAP3K8/CD247/CD3D/CD3E/IFNG/RASGRP1/NFKB1/NFATC2/PAK5/LCK/CD3G/ITK/CARD11/PAK3/PRKCQ/LCP2	2.98582252317662
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/715	142/9376	1.84694179060376	JUND/NFKBIA/FCGR3B/IL1B/TYROBP/FOSL1/CYBA/IFNG/NFKB1/RELB/LILRA5/NFATC2/IL1A/CAMK4/LCK/STAT1/MITF/LCP2/FOSL2/LILRB4	2.92184679084346
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/715	142/9376	1.84694179060376	TXN/MGST1/ACTB/IL1B/HSP90B1/HSP90AA1/DUSP1/CTSL/MAP3K5/RAC2/HSP90AB1/EDN1/CYBA/GSTM5/IFNG/GSTA1/NFKB1/IL1A/IL1R2/MAP2K5	2.92184679084346
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	29/715	232/9376	1.63916083916084	TMSB4X/RGCC/ACTB/F2R/ITGAX/MYL12B/ITGB1/FN1/ITGA6/RAC2/ITGB8/C6/EGFR/GSN/CFL1/CYRIB/ARPC2/CXCR4/PFN1/ARPC3/TIAM1/ITGA5/PAK5/ITGAE/PAK3/MYL5/ARPC5L/DIAPH1/ITGAL	2.83230932245254
NA	NA	hsa04518	Integrin signaling	21/715	154/9376	1.78817546090273	ACTB/ITGAX/TNC/COL4A4/ITGB1/FN1/ITGA6/RAC2/ITGB8/EGFR/ICAM3/VWF/VTN/ICAM2/LAMA3/VEGFC/ITGA5/C3/ITGAE/ITGAL/CDH1	2.83351392103749
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/715	184/9376	1.71042870173305	EFNB2/WNT5A/MYL12B/ITGB1/RAC2/SEMA3C/NRP1/TRPC4/BOC/CFL1/WNT4/CXCR4/EFNA5/NFATC2/PAK5/PLXNA4/PAK3/PLXNC1/SEMA7A/MYL5/BMP7/NEO1/EPHA5/EPHA4	2.79626960712983
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/715	71/9376	2.21633014872451	CXCL8/NFKBIA/CXCL2/CCL5/JAM2/ATP6V0E1/EGFR/NFKB1/CXCL3/CXCR2/LYN/ATP6V0C	2.955813967263
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/715	248/9376	1.58628468305888	CXCL8/TXN/NFKBIA/ACTB/ANXA2/IL1B/HSP90B1/PTPRC/TUBA4A/HSP90AA1/S100A10/MYL12B/GAPDH/HSP90AB1/TNFSF10/RHOH/ARPC2/DYNLL1/PFN1/NFKB1/ARPC3/MAP2K3/BIRC3/RIPK2/PAK3/TUBA3E/RALA/MYL5/TUBA1C/ARPC5L	2.68844535018237
Human Diseases	Immune disease	hsa05330	Allograft rejection	8/715	39/9376	2.68990496682804	GZMB/HLA-DRB5/PRF1/HLA-DQA2/HLA-DRA/IFNG/HLA-DPA1/HLA-DPB1	3.03840419012513
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/715	56/9376	2.34165834165834	CXCL8/NFKBIA/CXCL2/IL1B/HSPA6/HSPD1/HSPA8/NFKB1/C3/CXCL3	2.89322781924577
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/715	180/9376	1.67558663558664	NFKBIA/CD74/IL1B/B2M/HLA-DRB5/CALR/CCL5/HLA-DQA2/HLA-DRA/PILRA/TNFSF14/PDIA3/IFNG/HLA-DPA1/NFKB1/ITGA5/BIRC3/C3/IRF7/HLA-DPB1/STAT1/CFP/TAPBP	2.62949567517454
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	35/715	308/9376	1.49014621741894	SOD2/ATP5F1E/NDUFA4/MT-CO2/TGM2/TUBA4A/POLR2L/COX6C/CREB5/MT-ND3/MAP3K5/GPX1/PPIF/NDUFS5/UQCRQ/POLR2A/TAF4B/COX7A2/COX6B1/COX7A1/UQCR11/SEM1/NDUFA1/NDUFB1/NDUFA2/ATP5PF/COX7B/ERN1/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/CLTB/COX6A1	2.51304287269219
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/715	87/9376	1.9594566353187	MT-CO2/CACNB2/COX6C/UQCRQ/COX7A2/COX6B1/COX7A1/ATP1B3/UQCR11/COX7B/TPM3/UQCR10/COX6A1	2.58318277046105
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/715	116/9376	1.80872920183265	ACTB/MYL12B/ITGB1/RAP1B/JAM2/RAC2/RHOH/CLDN4/CYBA/THY1/CXCR4/CLDN3/ITK/MYL5/TXK/ITGAL	2.51814808485814
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/715	187/9376	1.61286414120639	CXCL8/TXN/NFKBIA/TNFAIP3/CXCL2/NAMPT/IL1B/HSP90AA1/CCL5/CARD16/ANTXR1/HSP90AB1/CYBA/MAP1LC3B/NFKB1/YWHAE/BIRC3/IRF7/GBP5/CXCL3/GBP1/RIPK2/STAT1	2.43223497224759
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/715	138/9376	1.71042870173305	CXCL8/NFKBIA/ACTB/IL1B/ITGB1/FN1/RAC2/FYB1/ARPC2/NFKB1/ARPC3/ITGA5/NFATC2/MAP2K3/LCK/LCP2/ARPC5L/WIPF3	2.41560379328366
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/715	201/9376	1.56576557770588	CXCL8/CEBPB/BCL2A1/GZMB/REL/NFKBIZ/BCL11B/IL2RB/PLAU/HPGD/MLF1/H3-3B/DDX5/ID2/NFKB1/GADD45A/GADD45B/BIRC3/WT1/WNT16/IL1R2/MITF/NR4A3/SUPT3H	2.32962572104971
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/715	233/9376	1.51956541312764	VIM/ACTB/PDLIM1/DCN/VCAN/COL4A4/SSPN/ITGB1/FN1/ITGA6/ITGB8/NEBL/SGCD/ANK3/BGN/FBLN1/ATP1B3/NID2/ITGA5/XIRP1/TPM3/DTNA/PDLIM2/MYL5/SNTB1/TRIM63/DIAPH1	2.30742967328489
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	41/715	388/9376	1.38568235887824	DKK1/ATP5F1E/NDUFA4/MT-CO2/IL1B/TUBA4A/WNT11/COX6C/MT-ND3/WNT5A/MAP3K5/GAPDH/PPIF/PTGS2/NDUFS5/LPL/WNT4/UQCRQ/COX7A2/COX6B1/COX7A1/UQCR11/SEM1/NFKB1/NDUFA1/NDUFB1/IL1A/IRS2/NDUFA2/WNT16/APOE/ATP5PF/COX7B/DKK2/ERN1/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/COX6A1	2.22930117742928
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/715	214/9376	1.53192601790733	NFKBIA/B2M/APOBEC3A/CALR/ELOB/RAC2/GNGT1/CD247/PDIA3/GNG5/CFL1/CD3D/CD3E/CXCR4/APOBEC3G/AP1S2/NFKB1/NFATC2/MAP2K3/PAK5/GNG4/CD3G/PAK3/ELOC/TAPBP	2.26160948086499
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/715	38/9376	2.41560544718439	PTPRC/IL7R/CD3D/IL2RG/CD3E/LCK/UNG	2.51224348373944
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/715	205/9376	1.53521405423844	ATP5F1E/NDUFA4/MT-CO2/COX6C/MT-ND3/GAPDH/RAC2/PPIF/NDUFS5/CYBA/UQCRQ/COX7A2/COX6B1/COX7A1/UQCR11/NFKB1/NDUFA1/NDUFB1/NDUFA2/ATP5PF/COX7B/UQCR10/NDUFB2/COX6A1	2.22613107811183
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/715	103/9376	1.78238848530111	CXCL8/NFKBIA/SERPINE1/IL1B/CALR/CCL5/CD247/CD3D/CD3E/IFNG/CCL3L1/NFKB1/C3/CD3G	2.29395858240473
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/715	31/9376	2.5380554928942	SRP14/SEC62/SEC61B/SEC61G/HSPA5/SPCS2	2.46443767203883
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/715	76/9376	1.89797570850202	UBC/MMP1/PLIN2/LPL/ACSL5/APOA1/GK/CPT1C/ACSL1/ME3/APOC3	2.25831516141995
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/715	212/9376	1.48452302414567	ACTB/F2R/ITGB1/RAP1B/RAC2/EGFR/FYB1/SKAP1/PFN1/ANGPT2/VEGFC/CNR1/RAP1GAP/EFNA5/RASGRP2/TIAM1/DOCK4/MAP2K3/FPR1/ID1/RALA/LCP2/ITGAL/CDH1	2.05019159718845
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/715	78/9376	1.84930966469428	ACTB/ITGB1/FN1/HCLS1/ARPC2/ARPC3/ITGA5/ARPC5L/SEPTIN1/CLTB/CDH1	2.16407962622397
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/715	78/9376	1.84930966469428	CXCL8/IL1B/ITGB1/IRF1/CFL1/C1S/NFKB1/ITGA5/IL1A/C3/IL23A	2.16407962622397
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/715	224/9376	1.46353646353646	NFKBIA/B2M/HLA-DRB5/IL15/CREB5/CALR/FOSL1/HLA-DQA2/IL2RB/TSPO/HLA-DRA/NRP1/CD3D/IL2RG/CD3E/HLA-DPA1/NFKB1/RELB/NFATC2/LCK/CD3G/IL1R2/HLA-DPB1/ANAPC15/ITGAL	2.01745820482878
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/715	203/9376	1.48574184436253	ACTB/TNC/COL4A4/MYL12B/ITGB1/RAP1B/FN1/ITGA6/RAC2/ITGB8/EGFR/EMP1/VWF/VTN/LAMA3/VEGFC/ITGA5/EMP2/BIRC3/PAK5/PAK3/MYL5/DIAPH1	2.01026114942305
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/715	204/9376	1.47845879610585	TIMP3/LUM/ACTB/CD63/DCN/WNT11/CTSL/CD44/WNT5A/ITGB1/FN1/PLAU/EGFR/HCLS1/WNT4/ANK3/VTN/DDX5/TIAM1/ITGA5/WNT16/HOXD10/PLAUR	1.98509933398235
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/715	34/9376	2.31410941999177	RORB/RORA/CRY1/BHLHE40/DBP/NR1D1	2.205493058982
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/715	52/9376	2.01742872512103	TSPO/LRPAP1/LPL/APOA1/APOE/LDLR/STAR/APOC3	2.11377702963044
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/715	44/9376	2.08620470438652	OSTC/TMEM258/HEXB/B4GALT1/KRTCAP2/DAD1/MGAT4C	2.07493880285656
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/715	93/9376	1.6920369952628	NFKBIA/COL4A4/ITGB1/FN1/ITGA6/PTGS2/LAMA3/NFKB1/GADD45A/GADD45B/BIRC3/FHIT	1.92699794122161
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/715	28/9376	2.34165834165834	GPHN/ALPL/PTS/GCH1/AKR1B1	2.04275479594212
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/715	170/9376	1.46560263266146	ACTB/MYL6/TUBA4A/MAP3K5/MYL12B/ITGB1/JAM2/CLDN4/HCLS1/ARPC2/CLDN3/CFTR/ARPC3/TIAM1/EPB41L4B/PALS1/TUBA3E/TUBA1C/ARPC5L	1.76018794573485
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/715	56/9376	1.87332667332667	OSTC/TMEM258/B4GALT1/KRTCAP2/DAD1/DPM3/MGAT4C/ALG5	1.88329096022684
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	46/715	480/9376	1.25668997668998	DKK1/ATP5F1E/NDUFA4/MT-CO2/IL1B/TUBA4A/UBC/WNT11/COX6C/MT-ND3/WNT5A/MAP3K5/UCHL1/GPX1/PPIF/PTGS2/NDUFS5/WNT4/UQCRQ/MAP1LC3B/COX7A2/COX6B1/COX7A1/SNCAIP/UQCR11/SEM1/PRKN/NFKB1/NDUFA1/NDUFB1/HSPA5/IL1A/NEFM/MAP2K3/NDUFA2/WNT16/ATP5PF/COX7B/DKK2/ERN1/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/COX6A1	1.65877232856526
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/715	38/9376	2.07051895472948	NAMPT/NNMT/NT5E/AOX1/PNP/BST1	1.8998261652552
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/715	98/9376	1.60570857713715	CREB5/ATP2B1/HSD3B2/HSD3B1/ATP1B3/NR4A2/CAMK4/LDLR/NPR1/ATP2B3/STAR/CACNA1G	1.73182584705691
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/715	99/9376	1.58948929858021	ACTB/CACNB2/SSPN/ITGB1/ITGA6/ITGB8/EDN1/SGCD/ITGA5/TPM3/DTNA/SNTB1	1.69412083742825
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/715	89/9376	1.62074330164218	TNC/CD44/COL4A4/ITGB1/FN1/ITGA6/ITGB8/VWF/VTN/LAMA3/ITGA5	1.69053420425172
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/715	200/9376	1.37689510489511	CXCL8/NFKBIA/ACTB/IL1B/TUBA4A/F2R/GAPDH/ITGB1/TNFSF10/CLDN4/HCLS1/ARPC2/CLDN3/NFKB1/ARPC3/PAK3/TUBA3E/TUBA1C/MYO1F/ARPC5L/WIPF3	1.54797318066966
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/715	50/9376	1.83586013986014	HLA-DRB5/IL15/HLA-DQA2/HLA-DRA/CXCR4/HLA-DPA1/HLA-DPB1	1.70265066238594
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/715	50/9376	1.83586013986014	CXCL8/IL1B/KLRB1/CSF3/CD81/IFNG/ITGAL	1.70265066238594
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/715	91/9376	1.58512256973795	NFKBIA/IFITM1/DAPP1/RAC2/CD81/NFKB1/LILRA5/NFATC2/CARD11/LYN/LILRB4	1.61150342269316
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	35/715	362/9376	1.26785921261059	PRL/HSP90B1/EREG/HSP90AA1/F2R/CREB5/TNC/COL4A4/ITGB1/FN1/IL2RB/IL7R/ITGA6/HSP90AB1/ITGB8/GNGT1/CSF3/CSF3R/EGFR/GNG5/IL2RG/VWF/VTN/ANGPT2/LAMA3/VEGFC/NFKB1/EFNA5/ITGA5/YWHAE/GNG4/OSM/MCL1/C8orf44-SGK3/IL3RA	1.49333325350922
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/715	14/9376	2.80999000999001	CHST2/B4GALT1/B3GNT7	1.94719980361953
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	18/715	168/9376	1.40499500499501	PRL/IL15/IL2RB/IL7R/CSF3/STAT4/CSF3R/EGFR/IL2RG/IFNG/AOX1/IL19/OSM/MCL1/STAT1/IL3RA/IL23A/CSF2RB	1.52186557127611
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/715	51/9376	1.79986288221582	ACTB/ATP6V0E1/SEC61B/CFTR/SEC61G/KCNQ1/ATP6V0C	1.64562490488928
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/715	103/9376	1.52776155882952	CXCL8/CXCL2/IL1B/COL4A4/FN1/CTSG/IFNG/LAMA3/NFKB1/IL1R2/CXCL3/HSPB1	1.54739388434934
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/715	42/9376	1.87332667332667	AOC1/MAOB/AOX1/ALDH2/KYAT3/KYNU	1.62975420928963
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	25/715	253/9376	1.29577931949473	CXCL8/NFKBIA/ACTB/IL1B/UBC/CCL5/CD44/MYL12B/ITGB1/EGFR/HCLS1/ARPC2/MAP1LC3B/PFN1/H3-3B/NFKB1/ARPC3/ITGA5/UBE2D1/C3/RIPK2/PRKCQ/MYL5/ARPC5L/DIAPH1	1.37029435418566
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/715	173/9376	1.36438821294313	CXCL8/NFKBIA/ACTB/TPSB2/IL1B/HLA-DRB5/CCL5/TPSAB1/HLA-DQA2/HLA-DRA/TNFSF10/IFNG/HLA-DPA1/NFKB1/IL1A/IRF7/HLA-DPB1/STAT1	1.38987998380976
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/715	54/9376	1.6998704998705	GZMB/HLA-DRB5/PRF1/HLA-DQA2/HLA-DRA/HLA-DPA1/HLA-DPB1	1.48188553370977
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/715	86/9376	1.52480078061473	ACTB/CACNB2/SSPN/ITGB1/ITGA6/ITGB8/SGCD/ITGA5/DTNA/SNTB1	1.40472231252663
Genetic Information Processing	Translation	hsa03010	Ribosome	22/715	222/9376	1.2995148995149	RPL39/RPL37/RPL34/RPLP1/RPL28/RPS21/RPL41/RPS28/RPS4X/RPL12/RPS29/RPL36/RPL30/RPS11/RPS15A/MRPL33/RPL35A/FAU/RPS27/RPS26/MRPL23/RPL26L1	1.29760976298454
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/715	98/9376	1.47189952904239	FCGR3B/PTPRC/PLPP1/RAC2/GSN/CFL1/ARPC2/SPHK1/ARPC3/LYN/ARPC5L	1.34924257713547
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/715	110/9376	1.43054036872219	EMP3/DCN/FMOD/NOG/ID3/IFNG/FST/ID2/ID1/BMP8B/BMP7/NEO1	1.3050246437689
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	34/715	368/9376	1.21155366372758	ACTB/ATP5F1E/NDUFA4/MT-CO2/TUBA4A/COX6C/MT-ND3/MAP3K5/GPX1/NDUFS5/UQCRQ/MAP1LC3B/COX7A2/COX6B1/PFN1/COX7A1/UQCR11/SEM1/PRKN/NDUFA1/NDUFB1/HSPA5/NEFM/MAP2K3/NDUFA2/ATP5PF/COX7B/ERN1/UQCR10/TUBA3E/NDUFB2/TUBA1C/PSMA2/COX6A1	1.18955605325301
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/715	226/9376	1.27651463580667	NFKBIA/PDE4B/F2R/CREB5/ATP2B1/RAP1B/RAC2/SSTR1/EDN1/OXTR/CFTR/ATP1B3/PDE4D/NFKB1/TIAM1/CAMK4/NPR1/SOX9/OXT/ATP2B3/HCAR3/PDE10A	1.20897253720217
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/715	157/9376	1.33638590708654	SERPINE1/ACTB/WNT11/WNT5A/FRMD6/WNT4/CCN2/ID2/YWHAE/BIRC3/WNT16/PALS1/ID1/BMP8B/BMP7/CDH1	1.22123811780589
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/715	227/9376	1.27089122331413	CXCL8/NFKBIA/IL1B/B2M/CREB5/CALR/CCL5/RAC2/GNGT1/PTGS2/EGFR/PDIA3/GNG5/CXCR4/AKAP13/CCL3L1/NFKB1/NFATC2/GNG4/PTGER4/CXCR2/TAPBP	1.18706824936796
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/715	101/9376	1.42817974105103	CXCL8/SERPINE1/IL1B/COL4A4/FN1/EDN1/VEGFC/NFKB1/IL1A/STAT1/DIAPH1	1.24303822150098
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/715	102/9376	1.41417797888386	ATP2B1/RAP1B/CPB1/CPA3/RAB27B/CFTR/KCNQ1/ATP1B3/BST1/ATP2B3/SCT	1.20839295430519
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	28/715	300/9376	1.22390675990676	JUND/CACNB2/IL1B/HSPA6/EREG/DUSP1/MAP3K5/DUSP2/RAP1B/MAP3K8/RAC2/PTPN7/HSPA8/EGFR/ANGPT2/RASGRP1/VEGFC/NFKB1/RELB/GADD45A/EFNA5/RASGRP2/IL1A/MAP2K3/GADD45B/MAP2K5/HSPB1/CACNA1G	1.13249222473964
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/715	136/9376	1.34989716166187	NFKBIA/TNFAIP3/IL1B/HSPA6/IL2RB/HSPA8/CD3D/IL2RG/CD3E/NFKB1/IL1A/IRF7/CD3G/STAT1	1.1809418896623
NA	NA	hsa03272	Virion - Hepatitis viruses	6/715	48/9376	1.63916083916084	CD63/EGFR/CLDN4/CD81/CLDN3/LDLR	1.27553138197181
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/715	59/9376	1.55581367784758	MGST1/GPX1/GPX4/GSTM5/GSTA1/GSS/GCLC	1.23047226152088
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/715	103/9376	1.40044809559373	COL4A4/COL17A1/CPB1/COL12A1/COL19A1/CPA3/COL25A1/KCNQ1/ATP1B3/SLC16A10/PRCP	1.17411153532165
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	8/715	70/9376	1.49866133866134	NFKBIA/ADIPOR2/NFKB1/ACSL5/IRS2/PRKCQ/CPT1C/ACSL1	1.20317232615776
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/715	105/9376	1.37377289377289	NFKBIA/IL1B/PTGS2/IRF1/NFKB1/RELB/NFATC2/CLEC4E/FCER1G/STAT1/IL23A	1.10660799021515
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/715	105/9376	1.37377289377289	ACTB/CACNB2/SSPN/ITGB1/ITGA6/ITGB8/SGCD/ITGA5/TPM3/DTNA/SNTB1	1.10660799021515
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/715	61/9376	1.50480339332798	FTH1/FTL/ATP2B1/ATP1B3/ATOX1/MT1X/ATP2B3	1.13645015784544
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	33/715	370/9376	1.16956340956341	TAC3/NPFFR2/PRL/GZMA/F2R/ADM/TSPO/C5AR1/CTSG/SSTR1/EDN1/OXTR/GRIK1/P2RY8/PENK/HTR2B/GAL/ADRA2C/CNR1/AVPR1A/C3/PTGER4/GRIK2/FPR1/GLRB/RXFP1/TACR1/S1PR3/OXT/UTS2/SCT/S1PR4/P2RY10	0.956140405142949
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/715	178/9376	1.25239255126896	DKK1/NOTUM/WNT11/WNT5A/FOSL1/RAC2/WNT4/SFRP2/CACYBP/NFATC2/WNT16/CTNND2/DKK2/CCDC88C/ROR2/SFRP4/APCDD1	0.976774857022037
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/715	250/9376	1.20642237762238	CD63/CTSS/CTSW/SLC11A1/CTSL/CTSH/LITAF/ATP6V0E1/CTSG/HEXB/LAPTM5/OSBPL1A/SUMF1/AP1S2/ARSG/LAMTOR2/MITF/ATP6V0C/NAGLU/AGA/NCOA7/CD68/CLTB	0.950476071752025
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/715	63/9376	1.45703185703186	WNT11/WNT5A/WNT4/GADD45A/GADD45B/WNT16/PTCH2	1.04574690115382
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/715	52/9376	1.51307154384077	HSD3B2/PTGS2/HSD3B1/LDLR/ALOX5/STAR	1.06594085379164
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/715	31/9376	1.6920369952628	PRPS2/RBKS/IDNK/PGLS	1.10885598695854
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/715	75/9376	1.39875058275058	SERPINE1/PERP/RPRM/TP53I3/SFN/GADD45A/GADD45B/SESN2	0.996143212390839
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/715	21/9376	1.87332667332667	DPYD/VNN2/ALDH2	1.15111606749229
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/715	65/9376	1.41220010758472	CREB5/HSD3B2/MRAP/HSD3B1/LDLR/STAR/CACNA1G	0.958122977817863
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/715	12/9376	2.18554778554779	NCAM2/NCAM1	1.18068385323322
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/715	22/9376	1.78817546090273	AOC1/MAOB/ALDH2	1.0633842089021
NA	NA	hsa04519	Cadherin signaling	35/715	404/9376	1.13605206674514	VIM/NFKBIA/ACTB/WNT11/KRT24/KRT6A/WNT5A/RAC2/KRT86/KRT10/KRT81/EGFR/KRT17/FAT3/CDH13/WNT4/KRT8/ARPC2/KRT5/PKP1/CDH15/TMC7/KRT14/NFKB1/ARPC3/MAP2K3/YWHAE/WNT16/PALS1/CTNND2/KRT19/DSC3/MYO1F/ARPC5L/CDH1	0.803166957841435
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/715	196/9376	1.20428143285286	CXCL8/NFKBIA/CXCL2/CLEC2B/UBC/GNGT1/PTGS2/GNG5/MAP1LC3B/ANGPT2/NFKB1/NFATC2/C3/GNG4/IRF7/CXCL3/STAT1/LYN	0.830405525427949
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/715	23/9376	1.71042870173305	CTSG/CPA3/PRCP	0.980084654840542
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/715	139/9376	1.22642249836494	HSP90B1/HSPA6/HSP90AA1/CREB5/KRT24/HSP90AB1/HSPA8/ESR2/KRT10/EGFR/KRT17/KRT14/KRT19	0.772709312424389
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/715	128/9376	1.22937062937063	PDE4B/NME3/NT5E/PDE7A/PRPS2/GUK1/PDE4D/PNP/NPR1/ENTPD3/FHIT/PDE10A	0.750712280529908
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/715	69/9376	1.33033343468126	RAC2/MAP2K3/FCER1G/MS4A2/LYN/LCP2/ALOX5	0.791273937110715
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/715	130/9376	1.21045723507262	NFKBIA/CREB5/COL4A4/MMP1/GNGT1/EGFR/EDN1/GNG5/VEGFC/NFKB1/GNG4/RXFP1	0.694245753320846
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/715	143/9376	1.19211697393516	FCGR3B/HLA-DRB5/HLA-DQA2/HLA-DRA/CTSG/C6/H2AC20/C1S/IFNG/HLA-DPA1/H3-3B/C3/HLA-DPB1	0.665145991470312
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/715	144/9376	1.18383838383838	CXCL8/NFKBIA/CXCL2/IL1B/MAP3K5/C5AR1/ADIPOR2/NFKB1/ALDH2/MAP2K3/C3/CXCL3/CPT1C	0.638740099085878
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/715	120/9376	1.20205128205128	NFKBIA/ARHGDIB/MAP3K5/RAP1B/ARHGDIG/MATK/NFKB1/CAMK4/YWHAE/MAP2K5/RIPK2	0.640022438744462
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/715	37/9376	1.41765261765262	GADD45A/GADD45B/TPM3/CDH1	0.731342011355477
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/715	109/9376	1.20305382690704	CXCL8/NFKBIA/IL1B/CCL5/MAP3K8/CCL3L1/NFKB1/MAP2K3/IRF7/STAT1	0.612645836198416
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/715	15/9376	1.74843822843823	HEXB/ST6GALNAC5	0.833479857542875
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/715	15/9376	1.74843822843823	ALPL/THTPA	0.833479857542875
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/715	110/9376	1.19211697393516	SERPINE1/TIMP1/ELOB/GAPDH/EGFR/EDN1/IFNG/ANGPT2/NFKB1/ELOC	0.582331887288053
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/715	50/9376	1.31132867132867	SAT1/AOC1/MAOB/P4HA3/ALDH2	0.634177828537433
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/715	39/9376	1.34495248341402	BHMT2/MTHFD1L/ST20-MTHFS/DMGDH	0.620215391736808
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/715	28/9376	1.40499500499501	B4GALT1/B3GNT5/ST3GAL4	0.616629035200993
Organismal Systems	Immune system	hsa04611	Platelet activation	11/715	126/9376	1.14481074481074	ACTB/F2R/MYL12B/ITGB1/RAP1B/VWF/RASGRP1/RASGRP2/FCER1G/LYN/LCP2	0.47018615112594
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/715	77/9376	1.19211697393516	RAC2/EGFR/NFKB1/GADD45A/GADD45B/STAT1/RALA	0.486348539364542
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/715	65/9376	1.21045723507262	PLPP1/GPAT2/LPL/AKR1B1/ALDH2/GK	0.489189374434229
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/715	115/9376	1.14028580115537	JUND/PDE4B/CREB5/GATA3/EGFR/AKAP13/PDE4D/PTHLH/NR4A2/MMP24	0.434898925418407
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/715	41/9376	1.2793450451987	CXCL8/MMP1/EGFR/CDH1	0.515027453401692
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/715	155/9376	1.09982404692082	WNT11/CREB5/WNT5A/RAP1B/HSD3B2/MRAP/EGFR/HSD3B1/WNT4/WNT16/LDLR/STAR/CACNA1G	0.360053179435476
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/715	30/9376	1.31132867132867	IL1B/NFKB1/ABCC3	0.490706145484511
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/715	18/9376	1.45703185703186	ACSL5/ACSL1	0.557629633823485
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/715	18/9376	1.45703185703186	HEXB/AGA	0.557629633823485
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/715	168/9376	1.09277389277389	FTH1/TNFAIP3/FTL/IL1B/HSP90AA1/HSP90AB1/TNFSF10/STAT4/H2AC20/IFNG/GLUL/IL1A/BIRC3/STAT1	0.348620085641773
NA	NA	hsa04081	Hormone signaling	18/715	219/9376	1.07780438739343	PRL/RAMP1/GNGT1/ESR2/SSTR1/GNG5/OXTR/ADIPOR2/PENK/ADRA2C/SLC16A10/RAMP2/PTHLH/AVPR1A/GNG4/IRS2/NPR1/OXT	0.334737353119428
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/715	55/9376	1.19211697393516	PLPP1/CERS4/HEXB/SPHK1/B4GALT6	0.410554170303567
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/715	43/9376	1.21984062449179	ACSL5/ALDH2/CPT1C/ACSL1	0.415131973188297
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/715	106/9376	1.11339226810925	NFKBIA/HSP90B1/HSP90AA1/CREB5/HSP90AB1/PLAU/EGFR/NFKB1/IL1R2	0.337327033931177
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/715	157/9376	1.08581354950782	CEBPB/CALR/DUSP2/MFGE8/PTGS2/SPHK1/CX3CR1/PROS1/NFATC2/PTGER4/SLC16A1/CPT1C/ALOX5	0.311543306290198
NA	NA	hsa04981	Folate transport and metabolism	3/715	31/9376	1.2690277464471	BHMT2/ABCC3/ST20-MTHFS	0.431065144418395
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/715	19/9376	1.38034596981965	HEXB/NAGLU	0.476806255277397
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/715	44/9376	1.19211697393516	CREB5/ARHGDIB/ARHGDIG/DYNLL1	0.366994326479722
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/715	133/9376	1.08455754771544	SOD2/IL7R/TNFSF10/EGFR/GADD45A/GADD45B/HOMER1/IRS2/C8orf44-SGK3/CDKN2D/S1PR4	0.282180087055023
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/715	32/9376	1.22937062937063	B4GALT1/AKR1B1/GALM	0.373422962741636
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/715	149/9376	1.05610362791571	NDUFA4/MT-ND3/GNGT1/PTGS2/NDUFS5/GNG5/NDUFA1/CNR1/NDUFB1/GNG4/NDUFA2/NDUFB2	0.198339155310055
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/715	46/9376	1.14028580115537	FTH1/FTL/EPRS1/CP	0.274035262251821
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/715	59/9376	1.11129548417684	NME3/DPYD/CDA/NT5E/ENTPD3	0.246388334023138
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/715	72/9376	1.09277389277389	CXCL8/NFKBIA/ISG15/RNF125/NFKB1/IRF7	0.227044934527893
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	26/715	333/9376	1.02386022386022	WNT11/CREB5/TNC/WNT5A/COL4A4/ITGB1/FN1/ITGA6/ITGB8/ATP6V0E1/PTGS2/IRF1/EGFR/WNT4/VWF/ISG15/VTN/LAMA3/NFKB1/ITGA5/PTGER4/WNT16/PALS1/OASL/STAT1/ATP6V0C	0.12737816996282
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/715	21/9376	1.24888444888445	CHST7/CHSY3	0.328050083445337
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/715	125/9376	1.04906293706294	MAP3K5/RAC2/CERS4/SPHK1/SPTSSA/NFKB1/FCER1G/MS4A2/S1PR3/S1PR4	0.158660511010497
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/715	34/9376	1.15705470999589	POLR2L/POLR1F/POLR2A	0.263587694834824
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/715	60/9376	1.09277389277389	RAC2/PTGS2/SPHK1/NFATC2/HSPB1	0.207129189105617
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/715	154/9376	1.02181454908728	ACTB/CACNB2/MYL6/RGS2/PTGS2/EGFR/OXTR/NFATC2/CAMK4/MAP2K5/NPR1/OXT	0.0784239443957788
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/715	75/9376	1.04906293706294	MGST1/MAP3K5/GSTM5/GSTA1/BIRC3/ERCC1	0.122567123032329
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/715	62/9376	1.05752312203925	SOD2/CRYAB/HSPA6/HSPA8/IRS2	0.130564411896945
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/715	195/9376	1.00871436256052	ACTB/FCGR3B/RAC2/C5AR1/PPIF/CTSG/H2AC20/CYBA/AQP9/VWF/H3-3B/NFKB1/C3/FPR1/ITGAL	0.0353315407374022
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/715	23/9376	1.14028580115537	B4GALT1/LARGE1	0.193533792580427
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/715	90/9376	1.0199222999223	SOD2/CREB5/ADIPOR2/NFKB1/CAMK4/IRS2/SESN2	0.0545633502712304
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/715	90/9376	1.0199222999223	AQP9/CFTR/ATP1B3/ABCC3/LDLR/ABCB1/SCT	0.0545633502712304
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/715	37/9376	1.06323946323946	MAOB/GSTZ1/AOX1	0.110737187528076
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/715	37/9376	1.06323946323946	IL1B/IFNG/APOA1	0.110737187528076
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/715	91/9376	1.00871436256052	PDE4B/GNGT1/GNG5/PDE7A/PDE4D/GNG4/PDE10A	0.0240004843756931
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/715	254/9376	0.980915147844282	F2R/ATP2B1/PPIF/EGFR/PHKG1/OXTR/CXCR4/SPHK1/HTR2B/VEGFC/NFATC2/CAMK4/AVPR1A/MST1R/TACR1/SLN/ATP2B3/CACNA1G/ORAI2	-0.088596234527597
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	7/715	93/9376	0.987021580569968	ACTB/MYL12B/RAP1B/RAC2/EGFR/MYL5/CDH1	-0.0361388013837115
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/715	93/9376	0.987021580569968	LYZ/CST3/ATP2B1/CST2/ATP1B3/BST1/ATP2B3	-0.0361388013837115
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/715	53/9376	0.98968201609711	ATP2B1/ATP1B3/ATP2B3/CLTB	-0.021642607257078
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/715	54/9376	0.971354571354571	BHMT2/KYAT3/GSS/GCLC	-0.0606530012687074
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/715	68/9376	0.964212258329905	ALDH1A1/ALDH1A2/AOX1/ALDH1A3/CYP26A1	-0.0850971867016915
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/715	82/9376	0.959508783899028	MGST1/NME3/DPYD/CDA/GSTM5/GSTA1	-0.105808620530996
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/715	83/9376	0.947948437105064	NFKBIA/IL1B/POLR2L/CCL5/NFKB1/IRF7	-0.136851477802389
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/715	41/9376	0.959508783899028	SEM1/RAD51B/BABAM2	-0.0746535092426193
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/715	70/9376	0.936663336663337	MGST1/HSD11B1/PTGS2/GSTM5/GSTA1	-0.15281898685472
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/715	70/9376	0.936663336663337	ELOB/RAP1B/PAK5/PAK3/ELOC	-0.15281898685472
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/715	56/9376	0.936663336663337	GAS1/BOC/SCUBE2/PTCH2	-0.136582757811006
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/715	154/9376	0.936663336663337	NME3/EPRS1/GPHN/ALPL/PTS/GCH1/ALDH2/MTHFD1L/GSS/GCLC/KYNU	-0.227697164119967
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/715	85/9376	0.925643767996709	NME3/CDA/NT5E/GUK1/PNP/ENTPD3	-0.197856465428736
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/715	99/9376	0.927202090838454	IL1B/PRKCH/HTR2B/MAP2K3/PTGER4/TRPA1/PRKCQ	-0.209212372690771
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/715	71/9376	0.923470895301881	PRL/ESR2/IRF1/NFKB1/STAT1	-0.185974011090689
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/715	28/9376	0.936663336663337	ATP6V0E1/ATP6V0C	-0.0964338451695682
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/715	57/9376	0.920230646546436	ACSL5/CPT1C/ACSL1/ELOVL5	-0.173557539188753
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/715	13/9376	1.00871436256052	XRCC4	0.00903346630627581
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/715	238/9376	0.936663336663337	REL/RAP1B/RAC2/GNGT1/EGFR/GNG5/ANGPT2/RASGRP1/VEGFC/NFKB1/EFNA5/RASGRP2/TIAM1/PAK5/GNG4/PAK3/RALA	-0.284362760700773
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/715	156/9376	0.92465483234714	NFKBIA/EGFR/CLDN4/CD81/IFNG/CLDN3/NFKB1/YWHAE/IRF7/LDLR/STAT1	-0.272650866369013
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/715	115/9376	0.912228640924293	DUSP1/MAOB/GNGT1/PTGS2/GNG5/HTR2B/GNG4/ALOX5	-0.272099310337637
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/715	101/9376	0.908841653396109	WNT11/WNT5A/EDN1/WNT4/WNT16/ASIP/MITF	-0.264639585140875
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/715	87/9376	0.904364600916325	EREG/RAC2/EGFR/GADD45A/GADD45B/RALA	-0.2574829398903
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/715	73/9376	0.898170322827857	MGST1/MAOB/GSTM5/AOX1/GSTA1	-0.250945219223576
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/715	73/9376	0.898170322827857	EGFR/GADD45A/GADD45B/MITF/CDH1	-0.250945219223576
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/715	73/9376	0.898170322827857	EGFR/GADD45A/GADD45B/ALK/FHIT	-0.250945219223576
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/715	116/9376	0.904364600916325	GNGT1/GNG5/SLC38A1/GRIK1/GLUL/HOMER1/GNG4/GRIK2	-0.297780884505557
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/715	59/9376	0.889036387341472	EGFR/GADD45A/GADD45B/CDH1	-0.245653629725732
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/715	45/9376	0.874219114219114	CFTR/ABCC3/ABCB1	-0.243002896801327
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/715	89/9376	0.884041800895733	TUBA4A/EGFR/HTR2B/MAP2K5/TUBA3E/TUBA1C	-0.315800913728095
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/715	89/9376	0.884041800895733	GNGT1/GPHN/GNG5/SLC38A1/GLUL/GNG4	-0.315800913728095
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/715	75/9376	0.874219114219114	HSP90B1/CREB5/GPX1/ATP1B3/HSPA5	-0.314220921646925
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/715	46/9376	0.855214350866525	IFNG/SEM1/PSMA2	-0.282825296671688
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/715	31/9376	0.846018497631401	DPYD/ALDH2	-0.246725698121748
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/715	31/9376	0.846018497631401	GLUL/PCCA	-0.246725698121748
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/715	105/9376	0.874219114219114	CITED2/UBC/MAP1LC3B/PRKN/ARIH1/TOMM7/MITF	-0.372392261558808
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/715	134/9376	0.880743137459555	MYL6/ADM/RAMP1/EDN1/PRKCH/RAMP2/AVPR1A/NPR1/PRKCQ	-0.399491401764464
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/715	47/9376	0.837018300848088	ALDH2/ACYP2/ME3	-0.321828768525691
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/715	149/9376	0.880086356596424	CXCL8/F2R/PLPP1/EGFR/SPHK1/AVPR1A/FCER1G/MS4A2/CXCR2/RALA	-0.423922153101213
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/715	63/9376	0.832589632589632	PTGS2/GPX4/HPGD/ALOX5	-0.383056170476561
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/715	63/9376	0.832589632589632	POLR2L/POLR2A/ERCC1/CCNH	-0.383056170476561
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/715	16/9376	0.81958041958042	MAOB	-0.207520199025581
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/715	16/9376	0.81958041958042	HEXB	-0.207520199025581
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/715	78/9376	0.840595302133764	HSPD1/BTG1/PABPC1/LSM1/LSM5	-0.40617041500509
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/715	48/9376	0.81958041958042	AOX1/PCCA/ALDH2	-0.360051527952656
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/715	250/9376	0.891703496503497	HSPA6/ARF5/IL2RB/HSPA8/EGFR/IL2RG/ARPC2/CXCR4/ARPC3/LDLR/VPS37B/CXCR2/ARAP2/WASHC3/ARPC5L/WIPF3/CLTB	-0.498653471650922
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/715	194/9376	0.878725398313027	ACTB/MYL6/TUBA4A/MYL12B/KIF21A/DYNLL1/TPM3/TUBA3E/MYL5/TUBA1C/BICDL1/MYO16/MYO1F	-0.490407064190815
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/715	33/9376	0.794744649290104	STX11/STX8	-0.339361774974879
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/715	49/9376	0.802854288568574	CREB5/MAOB/NFKB1	-0.39752919166908
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/715	17/9376	0.771369806663924	CYP7B1	-0.271080301781814
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/715	17/9376	0.771369806663924	KYAT3	-0.271080301781814
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/715	17/9376	0.771369806663924	GLUL	-0.271080301781814
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/715	140/9376	0.842997002997003	SERPINE1/GNGT1/GNG5/MAP1LC3B/SPHK1/CCN2/CAMK4/GNG4/CDH1	-0.537755224200796
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/715	66/9376	0.794744649290104	HSD11B1/HSD3B2/HSD3B1/CYP7B1	-0.480779846479897
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/715	51/9376	0.771369806663924	PLPP1/PLA2G7/PEDS1	-0.470380047041586
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/715	170/9376	0.848506787330317	MGST1/ACTB/WNT11/WNT5A/EGFR/WNT4/GSTM5/GSTA1/GADD45A/GADD45B/WNT16	-0.572712669766435
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/715	142/9376	0.831123805771693	UBC/ELOB/UBE2S/PRKN/UBE2D1/BIRC3/ANAPC15/ELOC/UBE2E2	-0.582602454655216
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/715	83/9376	0.789957030920886	SOD2/ACSL5/PEX7/ACSL1/PRDX5	-0.552234920947484
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/715	144/9376	0.81958041958042	MAP3K5/PPIF/RORA/SEM1/MYOD1/ERN1/BEAN1/PSMA2/DAB1	-0.626861584986225
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/715	69/9376	0.760190534103578	CREB5/MAOB/ARC/CAMK4	-0.574434678158978
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/715	37/9376	0.708826308826309	GLUL/ASNS	-0.509867636299325
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/715	20/9376	0.655664335664336	EBP	-0.442900874566739
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/715	20/9376	0.655664335664336	UAP1	-0.442900874566739
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/715	38/9376	0.690172984909827	UAP1/HEXB	-0.54984310868178
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/715	38/9376	0.690172984909827	ATP1B3/SFN	-0.54984310868178
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/715	150/9376	0.786797202797203	WNT11/WNT5A/EGFR/WNT4/GADD45A/GADD45B/WNT16/ABCB1/CDH1	-0.75628666429619
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/715	166/9376	0.789957030920886	RGS2/CREB5/ATP2B1/PPIF/ATP1B3/ADRA2C/NFATC2/IRS2/NPR1/ATP2B3	-0.78448928727886
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/715	41/9376	0.639672522599352	MAOB/DMGDH	-0.664334471886931
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/715	75/9376	0.699375291375291	GAPDH/PRPS2/GLUL/ASNS	-0.75100896632618
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/715	59/9376	0.666777290506104	PTGS2/IRS2/NPR1	-0.737695593474602
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/715	23/9376	0.570142900577683	GLUL	-0.593017069679688
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/715	23/9376	0.570142900577683	ATP1B3	-0.593017069679688
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/715	76/9376	0.690172984909827	ACTB/CFTR/KCNQ1/ATP1B3	-0.779182598115958
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/715	76/9376	0.690172984909827	EGFR/GADD45A/CAMK4/GADD45B	-0.779182598115958
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/715	77/9376	0.681209699391518	NFKBIA/NFKB1/GADD45A/GADD45B	-0.807024980087651
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/715	43/9376	0.609920312245894	PLPP1/APOA1	-0.736599756539022
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/715	24/9376	0.546386946386946	EXTL2	-0.639283588249475
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/715	44/9376	0.596058486967578	TAF4B/CCNH	-0.771635324438171
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/715	79/9376	0.663963884217049	MGST1/HSD11B1/GSTM5/GSTA1	-0.861752845370054
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/715	79/9376	0.663963884217049	ATP6V0E1/ATP6V0C/SYT1/CLTB	-0.861752845370054
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/715	144/9376	0.728515928515929	WNT11/WNT5A/WNT4/ID3/ID2/WNT16/JARID2/ID1	-0.943262006004251
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/715	63/9376	0.624442224442224	BBOX1/ALDH2/CAMKMT	-0.859323861020023
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/715	26/9376	0.504357181280258	APOA1	-0.727117046751516
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/715	115/9376	0.68417148069322	CREB5/GNGT1/GNG5/KCNQ1/CAMK4/GNG4	-0.979097546093681
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/715	65/9376	0.60522861753631	ESR2/TRPC4/CACNA1G	-0.917611435716675
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/715	27/9376	0.485677285677286	ELOVL5	-0.768935030756725
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/715	163/9376	0.724046505641598	CXCL8/NFKBIA/CREB5/STAT4/NFKB1/NFATC2/MAP2K3/IRF7/STAT1	-1.02113650978342
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/715	47/9376	0.558012200565392	IRS2/CACNA1G	-0.87276295397336
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/715	116/9376	0.678273450687244	GAPDH/PRPS2/PCCA/IDNK/PGLS/ME3	-1.00176312684648
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/715	148/9376	0.708826308826309	WNT11/WNT5A/ESR2/EGFR/WNT4/GADD45A/GADD45B/WNT16	-1.02584993805987
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/715	83/9376	0.631965624736709	L3MBTL4/UBE2D1/JARID2/SCMH1	-0.967618364092579
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/715	28/9376	0.468331668331668	ELOVL5	-0.809496725540129
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/715	67/9376	0.587162091639704	GAPDH/ALDH2/GALM	-0.974361454474357
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/715	49/9376	0.53523619237905	B4GALT1/GALNT13	-0.937160536839095
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/715	29/9376	0.452182300458163	FRMD6	-0.848894221380701
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/715	29/9376	0.452182300458163	GNGT1	-0.848894221380701
NA	NA	hsa04082	Neuroactive ligand signaling	11/715	199/9376	0.724855044453034	TAC3/GNGT1/GNG5/GRIK1/PENK/HTR2B/ADRA2C/GNG4/GRIK2/GLRB/TACR1	-1.12717764541234
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/715	86/9376	0.609920312245894	EREG/EGFR/PAK5/PAK3	-1.04411742758797
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/715	69/9376	0.570142900577683	EDN1/PTGER4/NPR1	-1.02967088324888
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/715	30/9376	0.437109557109557	PIGP	-0.88720964369272
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/715	154/9376	0.681209699391518	CACNB2/CREB5/ATP2B1/CREM/KCNQ1/ATP1B3/TPM3/ATP2B3	-1.14606048966721
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/715	122/9376	0.644915739997707	CREB5/CFTR/ADIPOR2/CAB39L/IRS2/CPT1C	-1.13423025868764
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/715	31/9376	0.4230092488157	ALDH2	-0.924516540661891
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/715	157/9376	0.668192953543272	CXCL8/SERPINE1/NFKB1/GADD45A/NFATC2/IL1A/MAP2K3/GADD45B	-1.20461471290263
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/715	32/9376	0.40979020979021	PCCA	-0.960881038274211
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/715	32/9376	0.40979020979021	ATG10	-0.960881038274211
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/715	32/9376	0.40979020979021	BIRC3	-0.960881038274211
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/715	158/9376	0.663963884217049	WNT11/WNT5A/SLC7A5/WNT4/CAB39L/WNT16/LAMTOR2/SESN2	-1.22391367559458
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/715	73/9376	0.538902193696714	APOBEC3A/CXCR4/APOBEC3G	-1.13631205852376
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/715	109/9376	0.601526913453519	NFKBIA/CREB5/NFKB1/IRS2/PRKCQ	-1.20225696323171
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/715	110/9376	0.596058486967578	HSP90AA1/HSP90AB1/ANAPC15/SPDYE2/SPDYE21	-1.22440000391406
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/715	35/9376	0.374665334665335	AKR1B1	-1.06488934184155
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/715	36/9376	0.364257964257964	AKR1B1	-1.09802791264488
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/715	36/9376	0.364257964257964	GALNT13	-1.09802791264488
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/715	97/9376	0.540754091269555	GNGT1/GNG5/GNG4/CACNA1G	-1.3062768057388
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/715	37/9376	0.354413154413154	UAP1	-1.13047246012673
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/715	217/9376	0.664728819567529	MGST1/HSP90B1/HSP90AA1/CREB5/HSP90AB1/ESR2/EGFR/GSTM5/KLF5/GSTA1/NFKB1	-1.43567686061589
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/715	122/9376	0.537429783331423	ACTB/WNT4/ATP1B3/SLC16A10/STAT1	-1.47756799050966
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/715	122/9376	0.537429783331423	CREB5/SSTR1/MAP2K3/IRS2/STAT1	-1.47756799050966
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/715	158/9376	0.580968398689918	SFN/GADD45A/GADD45B/YWHAE/ANAPC15/CCNH/CDKN2D	-1.52620055780244
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/715	107/9376	0.490216325730344	CREB5/PHKG1/SIK1/CPT1C	-1.52375804196728
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/715	67/9376	0.391441394426469	RAP1B/CAMK4	-1.43629263701729
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/715	44/9376	0.298029243483789	UNG	-1.34095014989712
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/715	68/9376	0.385684903331962	BCL2A1/NFKB1	-1.46073722552076
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/715	71/9376	0.369388358120752	SLC7A5/EGFR	-1.53245457324227
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/715	169/9376	0.543153887532586	UBC/CTSL/MAP1LC3B/ATG10/IRS2/ERN1/PRKCQ	-1.72190367988641
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/715	133/9376	0.492980703507019	CREB5/MAOB/GNGT1/GNG5/GNG4	-1.69199264983932
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/715	48/9376	0.273193473193473	ATP1B3	-1.45044013456897
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	9/715	205/9376	0.575705270339417	NFKBIA/REL/CREB5/GSN/NFKB1/YWHAE/C3/IRF7/LYN	-1.76478116838778
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/715	191/9376	0.549247611027716	CREB5/MAOB/GNGT1/H2AC20/GNG5/H3-3B/CAMK4/GNG4	-1.80829707683462
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/715	99/9376	0.397372324645052	PLPP1/RAC2/EGFR	-1.73187894078599
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/715	54/9376	0.242838642838643	ERCC1	-1.60319153624718
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/715	104/9376	0.378267885960194	PLPP1/GPAT2/PEMT	-1.83184151975105
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/715	323/9376	0.60897616315573	VIM/TIMP3/TNC/CD44/PLAU/PTGS2/EGFR/NFKB1/EFNA5/ITGA5/ZFPM2/IRS2/HOXD10/MCL1/ABCB1	-2.05476837852444
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/715	86/9376	0.304960156122947	CREB5/ATP1B3	-1.8603973409595
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/715	60/9376	0.218554778554779	LYN	-1.74467309939113
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/715	138/9376	0.380095267051789	YWHAE/ANAPC15/SPDYE2/SPDYE21	-2.10780366943406
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/715	93/9376	0.282006165877134	EGFR/MAP2K3	-1.99927554398904
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/715	117/9376	0.336238120853505	ACTB/H2AC20/BAZ1A	-2.07576332853463
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/715	99/9376	0.264914883096701	ESR2/EGFR	-2.1125455828098
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/715	103/9376	0.254626926471587	EIF4A3/PABPC1	-2.18542960592761
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/715	80/9376	0.163916083916084	EGFR	-2.15775158687484
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/715	138/9376	0.190047633525894	PHKG1/IRS2	-2.75400473553659
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/715	108/9376	0.121419321419321	EIF4A3	-2.63848818138466
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/715	183/9376	0.214971913332569	REXO2/NOP10/POP5	-3.08131962358739
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/715	243/9376	0.269820714265159	HSPA6/HSPA8/EIF4A3/DDX5/LSM5	-3.31345102776776
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/715	449/9376	0.0292055383369415	RGS2	-6.05692690951257