ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0023023 MHC protein complex binding 17/1273 37/18639 0.459459459459459 6.72730939895119 5.91915487358229e-11 6.41044472808962e-08 GO:0005178 integrin binding 35/1273 161/18639 0.217391304347826 3.1829980532122 7.0272207227243e-10 3.80524002135521e-07 GO:0023026 MHC class II protein complex binding 12/1273 27/18639 0.444444444444444 6.50746268656716 6.49693768749267e-08 2.34539450518485e-05 GO:0005125 cytokine activity 39/1273 234/18639 0.166666666666667 2.44029850746269 1.88167739938548e-07 4.51513157649998e-05 GO:0140375 immune receptor activity 30/1273 156/18639 0.192307692307692 2.81572904707233 2.08454828093258e-07 4.51513157649998e-05 GO:0004857 enzyme inhibitor activity 56/1273 416/18639 0.134615384615385 1.97101033295063 8.33489656385236e-07 0.000150444882977535 GO:0005201 extracellular matrix structural constituent 30/1273 168/18639 0.178571428571429 2.61460554371002 1.08946393423346e-06 0.000168555634396405 GO:0001664 G protein-coupled receptor binding 43/1273 297/18639 0.144781144781145 2.119855269109 2.36009813928915e-06 0.000319498285606269 GO:0061134 peptidase regulator activity 35/1273 226/18639 0.154867256637168 2.26753401135913 4.44699416362952e-06 0.000504965300559289 GO:0030547 signaling receptor inhibitor activity 13/1273 44/18639 0.295454545454545 4.32598371777476 4.66265282141541e-06 0.000504965300559289 GO:0044183 protein folding chaperone 17/1273 75/18639 0.226666666666667 3.31880597014925 9.22927449972985e-06 0.00090866402574613 GO:0030414 peptidase inhibitor activity 28/1273 169/18639 0.165680473372781 2.42585887132385 1.0888263946599e-05 0.000982665821180559 GO:0004866 endopeptidase inhibitor activity 27/1273 161/18639 0.167701863354037 2.45545564104941 1.23768698562438e-05 0.00103108846571631 GO:0042277 peptide binding 36/1273 249/18639 0.144578313253012 2.11688545225679 1.57615813810126e-05 0.00121927090254547 GO:0005520 insulin-like growth factor binding 8/1273 19/18639 0.421052631578947 6.16496465043205 1.77236526444605e-05 0.00122550680675447 GO:0001968 fibronectin binding 10/1273 30/18639 0.333333333333333 4.88059701492537 1.81053637193643e-05 0.00122550680675447 GO:0061135 endopeptidase regulator activity 29/1273 184/18639 0.157608695652174 2.30767358857885 2.03768780724852e-05 0.00122835725087729 GO:0005539 glycosaminoglycan binding 35/1273 242/18639 0.144628099173554 2.11761440730233 2.04159099868801e-05 0.00122835725087729 GO:0050786 RAGE receptor binding 6/1273 11/18639 0.545454545454545 7.98643147896879 3.43747902589055e-05 0.00195936304475762 GO:0002020 protease binding 23/1273 136/18639 0.169117647058824 2.47618525021949 4.64527912536671e-05 0.00251541864638608 GO:0140313 molecular sequestering activity 13/1273 55/18639 0.236363636363636 3.46078697421981 6.44386742910655e-05 0.00332319448843924 GO:0048306 calcium-dependent protein binding 16/1273 80/18639 0.2 2.92835820895522 8.54831584974411e-05 0.00408064400989393 GO:0005518 collagen binding 15/1273 72/18639 0.208333333333333 3.05037313432836 8.66618764797419e-05 0.00408064400989393 GO:0004869 cysteine-type endopeptidase inhibitor activity 10/1273 36/18639 0.277777777777778 4.06716417910448 0.000105091759155477 0.00474226563189088 GO:0031994 insulin-like growth factor I binding 6/1273 13/18639 0.461538461538462 6.75774971297359 0.00011332692412038 0.00490932235289486 GO:0001540 amyloid-beta binding 16/1273 83/18639 0.192771084337349 2.82251393634238 0.000135095442841466 0.00542580978370079 GO:0043394 proteoglycan binding 10/1273 37/18639 0.27027027027027 3.95724082291246 0.000135269495992541 0.00542580978370079 GO:0050840 extracellular matrix binding 14/1273 67/18639 0.208955223880597 3.05947872577411 0.000142920181304544 0.00552794844117218 GO:0070325 lipoprotein particle receptor binding 9/1273 31/18639 0.290322580645161 4.25084256138662 0.000160303363377 0.00598650146680312 GO:0016209 antioxidant activity 16/1273 86/18639 0.186046511627907 2.72405414786532 0.000208153894847581 0.00751435560399767 GO:0008201 heparin binding 25/1273 172/18639 0.145348837209302 2.12816730301978 0.000273929750749894 0.00944603128249224 GO:0005507 copper ion binding 13/1273 63/18639 0.206349206349206 3.02132196162047 0.000279107110840029 0.00944603128249224 GO:0009055 electron transfer activity 19/1273 116/18639 0.163793103448276 2.39822439526505 0.000315056455966767 0.0103395800549094 GO:0019838 growth factor binding 21/1273 136/18639 0.154411764705882 2.26086479367867 0.000359818702055875 0.0114612839507798 GO:0030021 extracellular matrix structural constituent conferring compression resistance 7/1273 22/18639 0.318181818181818 4.65875169606513 0.000467290143970807 0.0144592921691538 GO:0051082 unfolded protein binding 19/1273 121/18639 0.15702479338843 2.29912421364253 0.000543737505043042 0.0163574366100448 GO:0042562 hormone binding 16/1273 94/18639 0.170212765957447 2.49221975230232 0.000590622968559827 0.0172876939175755 GO:0044389 ubiquitin-like protein ligase binding 38/1273 322/18639 0.118012422360248 1.72791322888662 0.000699306937061256 0.0195399532945963 GO:0004896 cytokine receptor activity 16/1273 96/18639 0.166666666666667 2.44029850746269 0.000749563169697762 0.0195399532945963 GO:0033218 amide binding 31/1273 247/18639 0.125506072874494 1.83763369387878 0.000763771682147655 0.0195399532945963 GO:0051087 protein-folding chaperone binding 20/1273 134/18639 0.149253731343284 2.18534194698151 0.000766041259108527 0.0195399532945963 GO:0019955 cytokine binding 21/1273 144/18639 0.145833333333333 2.13526119402985 0.000781011008362136 0.0195399532945963 GO:0030246 carbohydrate binding 34/1273 280/18639 0.121428571428571 1.77793176972281 0.000791250480371369 0.0195399532945963 GO:0031625 ubiquitin protein ligase binding 36/1273 302/18639 0.119205298013245 1.7453790649402 0.000793866985191353 0.0195399532945963 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/1273 54/18639 0.203703703703704 2.98258706467662 0.000905719204519954 0.0217976421887802 GO:0005126 cytokine receptor binding 33/1273 275/18639 0.12 1.75701492537313 0.00114727384947873 0.0270108169344667 GO:0019956 chemokine binding 8/1273 33/18639 0.242424242424242 3.54952510176391 0.00137989078217504 0.0311337857728243 GO:0140311 protein sequestering activity 8/1273 33/18639 0.242424242424242 3.54952510176391 0.00137989078217504 0.0311337857728243 GO:0050750 low-density lipoprotein particle receptor binding 7/1273 26/18639 0.269230769230769 3.94202066590126 0.0014166393627301 0.0313106210170755 GO:0004601 peroxidase activity 11/1273 57/18639 0.192982456140351 2.82560879811469 0.00144684015713345 0.0313385578035104 GO:0004065 arylsulfatase activity 5/1273 14/18639 0.357142857142857 5.22921108742004 0.00175287020467303 0.0365068929165556 GO:0008191 metalloendopeptidase inhibitor activity 5/1273 14/18639 0.357142857142857 5.22921108742004 0.00175287020467303 0.0365068929165556 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/1273 59/18639 0.186440677966102 2.72982544902606 0.00193673556013327 0.0395751813514026 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 12/1273 68/18639 0.176470588235294 2.5838454784899 0.00201032049557009 0.0403180943833779 GO:0031386 protein tag activity 5/1273 15/18639 0.333333333333333 4.88059701492537 0.0024825644403617 0.0480110230162808 GO:0141047 molecular tag activity 5/1273 15/18639 0.333333333333333 4.88059701492537 0.0024825644403617 0.0480110230162808 GO:0015026 coreceptor activity 11/1273 61/18639 0.180327868852459 2.6403229752875 0.00255370067072727 0.048368493628334 GO:0097110 scaffold protein binding 12/1273 70/18639 0.171428571428571 2.51002132196162 0.00259037177326258 0.048368493628334 GO:0005246 calcium channel regulator activity 10/1273 53/18639 0.188679245283019 2.76260208392002 0.00279621356831395 0.0506853566594655 GO:0051861 glycolipid binding 7/1273 29/18639 0.241379310344828 3.53422542460113 0.0028080530005244 0.0506853566594655 GO:0005528 FK506 binding 4/1273 10/18639 0.4 5.85671641791045 0.00325733250289455 0.0578310016497507 GO:0001965 G-protein alpha-subunit binding 7/1273 30/18639 0.233333333333333 3.41641791044776 0.00345009345473876 0.0593087493886044 GO:0048019 receptor antagonist activity 7/1273 30/18639 0.233333333333333 3.41641791044776 0.00345009345473876 0.0593087493886044 GO:0004602 glutathione peroxidase activity 6/1273 23/18639 0.260869565217391 3.81959766385464 0.00369163413575888 0.0624693713910448 GO:0003735 structural constituent of ribosome 22/1273 175/18639 0.125714285714286 1.84068230277186 0.00408204357727064 0.0680131260643708 GO:0005164 tumor necrosis factor receptor binding 7/1273 31/18639 0.225806451612903 3.30621088107848 0.00419804522521541 0.0688861057410347 GO:0017171 serine hydrolase activity 24/1273 198/18639 0.121212121212121 1.77476255088195 0.00446199956096334 0.0721245600675119 GO:0008484 sulfuric ester hydrolase activity 5/1273 17/18639 0.294117647058824 4.30640913081651 0.00456206103166934 0.072657530842616 GO:0042608 T cell receptor binding 4/1273 11/18639 0.363636363636364 5.32428765264586 0.00484387765069005 0.0751039052291544 GO:0015036 disulfide oxidoreductase activity 8/1273 40/18639 0.2 2.92835820895522 0.00499846640511575 0.0751039052291544 GO:0140662 ATP-dependent protein folding chaperone 8/1273 40/18639 0.2 2.92835820895522 0.00499846640511575 0.0751039052291544 GO:0071813 lipoprotein particle binding 7/1273 32/18639 0.21875 3.20289179104478 0.0050624054309587 0.0751039052291544 GO:0071814 protein-lipid complex binding 7/1273 32/18639 0.21875 3.20289179104478 0.0050624054309587 0.0751039052291544 GO:0004812 aminoacyl-tRNA ligase activity 8/1273 41/18639 0.195121951219512 2.8569348380051 0.00584619854054129 0.0844191069254162 GO:0016875 ligase activity, forming carbon-oxygen bonds 8/1273 41/18639 0.195121951219512 2.8569348380051 0.00584619854054129 0.0844191069254162 GO:0032393 MHC class I receptor activity 5/1273 18/18639 0.277777777777778 4.06716417910448 0.00596619556040575 0.0850182867357819 GO:0022853 active monoatomic ion transmembrane transporter activity 16/1273 118/18639 0.135593220338983 1.98532759929168 0.00646258496671176 0.0908958379084264 GO:0016859 cis-trans isomerase activity 8/1273 42/18639 0.19047619047619 2.78891257995736 0.00679893125885469 0.0935962867761456 GO:0005527 macrolide binding 4/1273 12/18639 0.333333333333333 4.88059701492537 0.00687676637617324 0.0935962867761456 GO:0008236 serine-type peptidase activity 23/1273 194/18639 0.118556701030928 1.73588244345284 0.00691385313212525 0.0935962867761456 GO:0004713 protein tyrosine kinase activity 18/1273 140/18639 0.128571428571429 1.88251599147122 0.00703118334562969 0.0940095254730489 GO:0015035 protein-disulfide reductase activity 7/1273 34/18639 0.205882352941176 3.01448639157155 0.00718316754260749 0.0948703713249258 GO:0003756 protein disulfide isomerase activity 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0974518834586077 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0974518834586077 GO:0043395 heparan sulfate proteoglycan binding 5/1273 19/18639 0.263157894736842 3.85310290652003 0.00764857811078639 0.0974518834586077 GO:0008200 ion channel inhibitor activity 8/1273 43/18639 0.186046511627907 2.72405414786532 0.00786444269449321 0.0990371097457692 GO:0001671 ATPase activator activity 6/1273 27/18639 0.222222222222222 3.25373134328358 0.00856757992135238 0.10543964835028 GO:0005044 scavenger receptor activity 6/1273 27/18639 0.222222222222222 3.25373134328358 0.00856757992135238 0.10543964835028 GO:0016248 channel inhibitor activity 8/1273 44/18639 0.181818181818182 2.66214382632293 0.00905056139940467 0.108330248346624 GO:0016860 intramolecular oxidoreductase activity 9/1273 53/18639 0.169811320754717 2.48634187552802 0.00911395095422357 0.108330248346624 GO:0005200 structural constituent of cytoskeleton 15/1273 112/18639 0.133928571428571 1.96095415778252 0.00916989145711227 0.108330248346624 GO:0042379 chemokine receptor binding 11/1273 72/18639 0.152777777777778 2.23694029850746 0.00932119308827702 0.108330248346624 GO:0019855 calcium channel inhibitor activity 4/1273 13/18639 0.307692307692308 4.50516647531573 0.00940262543359432 0.108330248346624 GO:0039706 co-receptor binding 4/1273 13/18639 0.307692307692308 4.50516647531573 0.00940262543359432 0.108330248346624 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/1273 36/18639 0.194444444444444 2.84701492537313 0.00989861920601012 0.110517573197 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/1273 36/18639 0.194444444444444 2.84701492537313 0.00989861920601012 0.110517573197 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/1273 36/18639 0.194444444444444 2.84701492537313 0.00989861920601012 0.110517573197 GO:0016874 ligase activity 20/1273 167/18639 0.119760479041916 1.75350790955403 0.0101192781561943 0.111142871247197 GO:0008009 chemokine activity 8/1273 45/18639 0.177777777777778 2.60298507462687 0.0103651246500156 0.111142871247197 GO:0042605 peptide antigen binding 8/1273 45/18639 0.177777777777778 2.60298507462687 0.0103651246500156 0.111142871247197 GO:0141110 transporter inhibitor activity 8/1273 45/18639 0.177777777777778 2.60298507462687 0.0103651246500156 0.111142871247197 GO:0044325 transmembrane transporter binding 17/1273 136/18639 0.125 1.83022388059702 0.011324943949796 0.120244257819893 GO:0035401 histone H3Y41 kinase activity 15/1273 115/18639 0.130434782608696 1.90979883192732 0.011585453126075 0.120644670534031 GO:0140801 histone H2AXY142 kinase activity 15/1273 115/18639 0.130434782608696 1.90979883192732 0.011585453126075 0.120644670534031 GO:0043236 laminin binding 6/1273 29/18639 0.206896551724138 3.02933607822954 0.0122384972411948 0.126139414109826 GO:0042043 neurexin family protein binding 4/1273 14/18639 0.285714285714286 4.18336886993603 0.0124625275251629 0.126139414109826 GO:0044548 S100 protein binding 4/1273 14/18639 0.285714285714286 4.18336886993603 0.0124625275251629 0.126139414109826 GO:1901681 sulfur compound binding 29/1273 275/18639 0.105454545454545 1.5440434192673 0.013243410998348 0.132089099377374 GO:0005109 frizzled binding 7/1273 38/18639 0.184210526315789 2.69717203456402 0.0132942860869194 0.132089099377374 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 7/1273 39/18639 0.179487179487179 2.62801377726751 0.0152731506382065 0.150371110374343 GO:0004129 cytochrome-c oxidase activity 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.155600073450182 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/1273 15/18639 0.266666666666667 3.9044776119403 0.0160916050105451 0.155600073450182 GO:0060590 ATPase regulator activity 8/1273 49/18639 0.163265306122449 2.39049649710631 0.0170625269704091 0.163528466450912 GO:0004252 serine-type endopeptidase activity 20/1273 176/18639 0.113636363636364 1.66383989145183 0.0173028047718224 0.164376645332313 GO:0016493 C-C chemokine receptor activity 5/1273 23/18639 0.217391304347826 3.1829980532122 0.0176438990122748 0.166159501132988 GO:0015399 primary active transmembrane transporter activity 19/1273 166/18639 0.114457831325301 1.67586764970329 0.0186542221407273 0.174159677400066 GO:0032813 tumor necrosis factor receptor superfamily binding 8/1273 50/18639 0.16 2.34268656716418 0.0191342514052546 0.177114480956331 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/1273 41/18639 0.170731707317073 2.49981798325446 0.0198421883471706 0.181022125203401 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/1273 60/18639 0.15 2.19626865671642 0.0198907044313986 0.181022125203401 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.181862146498226 GO:0055102 lipase inhibitor activity 4/1273 16/18639 0.25 3.66044776119403 0.0203188547795802 0.181862146498226 GO:0016247 channel regulator activity 19/1273 168/18639 0.113095238095238 1.65591684434968 0.0208946240510747 0.185478797573693 GO:0019957 C-C chemokine binding 5/1273 24/18639 0.208333333333333 3.05037313432836 0.0210654590042144 0.185478797573693 GO:0001618 virus receptor activity 11/1273 81/18639 0.135802469135802 1.98839137645108 0.0214740265033453 0.186777295252123 GO:0016853 isomerase activity 20/1273 180/18639 0.111111111111111 1.62686567164179 0.0215578595628028 0.186777295252123 GO:0030296 protein tyrosine kinase activator activity 6/1273 33/18639 0.181818181818182 2.66214382632293 0.0226379486771474 0.194578558867862 GO:0140272 exogenous protein binding 11/1273 82/18639 0.134146341463415 1.9641427011285 0.0233249069026062 0.197447134846367 GO:0141108 transporter regulator activity 19/1273 170/18639 0.111764705882353 1.63643546971027 0.0233363187999399 0.197447134846367 GO:0017124 SH3 domain binding 14/1273 115/18639 0.121739130434783 1.78247890979883 0.0249341455712476 0.202877985152046 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.202877985152046 GO:0051787 misfolded protein binding 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.202877985152046 GO:0070492 oligosaccharide binding 4/1273 17/18639 0.235294117647059 3.4451273046532 0.0251670990097066 0.202877985152046 GO:0099106 ion channel regulator activity 18/1273 160/18639 0.1125 1.64720149253731 0.0252500520881767 0.202877985152046 GO:0008375 acetylglucosaminyltransferase activity 7/1273 43/18639 0.162790697674419 2.38354737938216 0.0252870836396223 0.202877985152046 GO:0030165 PDZ domain binding 11/1273 83/18639 0.132530120481928 1.94047833123539 0.0252894995341885 0.202877985152046 GO:0032395 MHC class II receptor activity 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.20971920495101 GO:0043208 glycosphingolipid binding 3/1273 10/18639 0.3 4.39253731343284 0.0265295762495737 0.20971920495101 GO:0003954 NADH dehydrogenase activity 7/1273 44/18639 0.159090909090909 2.32937584803256 0.0283588581175013 0.22096135490964 GO:0001637 G protein-coupled chemoattractant receptor activity 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.22096135490964 GO:0004950 chemokine receptor activity 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.22096135490964 GO:0019865 immunoglobulin binding 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.22096135490964 GO:0043548 phosphatidylinositol 3-kinase binding 5/1273 26/18639 0.192307692307692 2.81572904707233 0.0291363517231012 0.22096135490964 GO:0051287 NAD binding 8/1273 54/18639 0.148148148148148 2.16915422885572 0.0292203210268222 0.22096135490964 GO:0003779 actin binding 41/1273 443/18639 0.0925507900677201 1.3551093292005 0.0293799031458802 0.22096135490964 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.225831811918146 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.225831811918146 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1273 18/18639 0.222222222222222 3.25373134328358 0.0306530714237926 0.225831811918146 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/1273 45/18639 0.155555555555556 2.27761194029851 0.0316734932299329 0.23135289430507 GO:0038024 cargo receptor activity 9/1273 65/18639 0.138461538461538 2.02732491389208 0.0318297149136246 0.23135289430507 GO:0098632 cell-cell adhesion mediator activity 8/1273 55/18639 0.145454545454545 2.12971506105834 0.0322229348666844 0.232649589737462 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.246964706722105 GO:0019215 intermediate filament binding 3/1273 11/18639 0.272727272727273 3.9932157394844 0.0346617132241551 0.246964706722105 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/1273 46/18639 0.152173913043478 2.22809863724854 0.0352376700877415 0.249427429444601 GO:0005179 hormone activity 15/1273 132/18639 0.113636363636364 1.66383989145183 0.0358150697245245 0.25186831501078 GO:0019207 kinase regulator activity 28/1273 287/18639 0.0975609756097561 1.42846741900255 0.0362915212572945 0.253572371107419 GO:0016918 retinal binding 4/1273 19/18639 0.210526315789474 3.08248232521602 0.0367876029739276 0.255390859107459 GO:0030280 structural constituent of skin epidermis 6/1273 37/18639 0.162162162162162 2.37434449374748 0.0377591119206694 0.260465721083344 GO:0046875 ephrin receptor binding 5/1273 28/18639 0.178571428571429 2.61460554371002 0.038924920791605 0.266153223702113 GO:0019199 transmembrane receptor protein kinase activity 10/1273 78/18639 0.128205128205128 1.87715269804822 0.039075127025518 0.266153223702113 GO:1990841 promoter-specific chromatin binding 9/1273 68/18639 0.132352941176471 1.93788410886743 0.0409940427435613 0.27747842682048 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8/1273 58/18639 0.137931034482759 2.01955738548636 0.0424721091197851 0.284152825028482 GO:0019210 kinase inhibitor activity 11/1273 90/18639 0.122222222222222 1.78955223880597 0.0425048547134018 0.284152825028482 GO:0004126 cytidine deaminase activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.290054885572447 GO:0004859 phospholipase inhibitor activity 3/1273 12/18639 0.25 3.66044776119403 0.0439233621734823 0.290054885572447 GO:0015078 proton transmembrane transporter activity 19/1273 185/18639 0.102702702702703 1.50375151270674 0.0490960384672709 0.322248543394269 GO:0031624 ubiquitin conjugating enzyme binding 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.326936479365805 GO:0070566 adenylyltransferase activity 5/1273 30/18639 0.166666666666667 2.44029850746269 0.0504943911999667 0.326936479365805 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/1273 21/18639 0.19047619047619 2.78891257995736 0.0510177885621616 0.326936479365805 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/1273 21/18639 0.19047619047619 2.78891257995736 0.0510177885621616 0.326936479365805 GO:0005006 epidermal growth factor receptor activity 7/1273 50/18639 0.14 2.04985074626866 0.0520988662967485 0.328041117438248 GO:0005017 platelet-derived growth factor receptor activity 7/1273 50/18639 0.14 2.04985074626866 0.0520988662967485 0.328041117438248 GO:0005019 platelet-derived growth factor beta-receptor activity 7/1273 50/18639 0.14 2.04985074626866 0.0520988662967485 0.328041117438248 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/1273 40/18639 0.15 2.19626865671642 0.0525303025269981 0.328845766686352 GO:0017154 semaphorin receptor activity 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.33591307771812 GO:0089720 caspase binding 3/1273 13/18639 0.230769230769231 3.3788748564868 0.0542795831954488 0.33591307771812 GO:1990782 protein tyrosine kinase binding 13/1273 117/18639 0.111111111111111 1.62686567164179 0.0560621299331421 0.344973219986323 GO:0017147 Wnt-protein binding 5/1273 31/18639 0.161290322580645 2.36157920077034 0.0569562720271081 0.346718617372868 GO:0005021 vascular endothelial growth factor receptor activity 7/1273 51/18639 0.137254901960784 2.00965759438104 0.0569860700760577 0.346718617372868 GO:0042287 MHC protein binding 6/1273 41/18639 0.146341463414634 2.14270112850382 0.05813397924354 0.351726812965105 GO:0051117 ATPase binding 10/1273 84/18639 0.119047619047619 1.74307036247335 0.0597271917624276 0.358618009563131 GO:0004521 RNA endonuclease activity 9/1273 73/18639 0.123287671232877 1.80515232058884 0.059935235208612 0.358618009563131 GO:0031072 heat shock protein binding 14/1273 131/18639 0.106870229007634 1.56477156203714 0.0635427101294139 0.375134628090055 GO:0043425 bHLH transcription factor binding 5/1273 32/18639 0.15625 2.28777985074627 0.0638699041961107 0.375134628090055 GO:0120015 sterol transfer activity 5/1273 32/18639 0.15625 2.28777985074627 0.0638699041961107 0.375134628090055 GO:0042056 chemoattractant activity 6/1273 42/18639 0.142857142857143 2.09168443496802 0.0640811691566577 0.375134628090055 GO:0005161 platelet-derived growth factor receptor binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.380406557355441 GO:0032036 myosin heavy chain binding 3/1273 14/18639 0.214285714285714 3.13752665245203 0.0656842347418905 0.380406557355441 GO:0004864 protein phosphatase inhibitor activity 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.384649642729013 GO:0005544 calcium-dependent phospholipid binding 7/1273 53/18639 0.132075471698113 1.93382145874402 0.0675850769809847 0.384649642729013 GO:0031681 G-protein beta-subunit binding 4/1273 23/18639 0.173913043478261 2.54639844256976 0.0678375639531315 0.384649642729013 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/1273 23/18639 0.173913043478261 2.54639844256976 0.0678375639531315 0.384649642729013 GO:0019887 protein kinase regulator activity 24/1273 255/18639 0.0941176470588235 1.37805092186128 0.0690271771117106 0.389356420895743 GO:0004540 RNA nuclease activity 13/1273 121/18639 0.107438016528926 1.57308498828173 0.0695352117191539 0.390189814983646 GO:0008194 UDP-glycosyltransferase activity 15/1273 145/18639 0.103448275862069 1.51466803911477 0.0705270252070227 0.393597305754018 GO:0071889 14-3-3 protein binding 5/1273 33/18639 0.151515151515152 2.21845318860244 0.0712327533959257 0.393597305754018 GO:0140416 transcription regulator inhibitor activity 5/1273 33/18639 0.151515151515152 2.21845318860244 0.0712327533959257 0.393597305754018 GO:0008528 G protein-coupled peptide receptor activity 13/1273 122/18639 0.10655737704918 1.56019084903352 0.0732076651758301 0.402456352210274 GO:0098631 cell adhesion mediator activity 9/1273 76/18639 0.118421052631579 1.73389630793401 0.0736119900101177 0.402635278691704 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.410501120025384 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.410501120025384 GO:0005540 hyaluronic acid binding 4/1273 24/18639 0.166666666666667 2.44029850746269 0.0771919849429149 0.410501120025384 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.410501120025384 GO:0005041 low-density lipoprotein particle receptor activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.410501120025384 GO:0017081 chloride channel regulator activity 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.410501120025384 GO:0033130 acetylcholine receptor binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.410501120025384 GO:0050700 CARD domain binding 3/1273 15/18639 0.2 2.92835820895522 0.0780823921747267 0.410501120025384 GO:0051015 actin filament binding 20/1273 209/18639 0.0956937799043062 1.40112832964365 0.0796261077403558 0.41659456368505 GO:0019212 phosphatase inhibitor activity 7/1273 56/18639 0.125 1.83022388059702 0.0855549465112398 0.445461572459965 GO:0004709 MAP kinase kinase kinase activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.449465387936297 GO:0120020 cholesterol transfer activity 4/1273 25/18639 0.16 2.34268656716418 0.0871539533394483 0.449465387936297 GO:0004175 endopeptidase activity 35/1273 405/18639 0.0864197530864197 1.2653399668325 0.089751347569096 0.460463589418536 GO:0032934 sterol binding 8/1273 68/18639 0.117647058823529 1.7225636523266 0.0911007516714646 0.460463589418536 GO:0004708 MAP kinase kinase activity 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.460463589418536 GO:0016722 oxidoreductase activity, acting on metal ions 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.460463589418536 GO:0019841 retinol binding 3/1273 16/18639 0.1875 2.74533582089552 0.0914124392659144 0.460463589418536 GO:0016504 peptidase activator activity 7/1273 57/18639 0.12280701754386 1.79811468970935 0.0920944592774563 0.461751386099468 GO:0141003 histone H2AX kinase activity 31/1273 354/18639 0.0875706214689266 1.28219074120921 0.0925694447755935 0.461994049271741 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/1273 36/18639 0.138888888888889 2.03358208955224 0.0959603255995104 0.476720333138852 GO:0043178 alcohol binding 10/1273 92/18639 0.108695652173913 1.5914990266061 0.0966968671362663 0.478185877208111 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/1273 26/18639 0.153846153846154 2.25258323765786 0.0977026081787839 0.47952615473416 GO:0001653 peptide receptor activity 13/1273 128/18639 0.1015625 1.48705690298507 0.0978534443178664 0.47952615473416 GO:0005504 fatty acid binding 6/1273 47/18639 0.127659574468085 1.86916481422674 0.0989353030493065 0.482643843254049 GO:0140996 histone H3 kinase activity 31/1273 357/18639 0.0868347338935574 1.27141602909821 0.100356018939426 0.487379230992818 GO:0005092 GDP-dissociation inhibitor activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:0017110 nucleoside diphosphate phosphatase activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:0030169 low-density lipoprotein particle binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:0045125 bioactive lipid receptor activity 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:1990226 histone methyltransferase binding 3/1273 17/18639 0.176470588235294 2.5838454784899 0.105607869320816 0.495076579471301 GO:0001786 phosphatidylserine binding 7/1273 59/18639 0.11864406779661 1.73716164938022 0.105984554977716 0.495076579471301 GO:0070888 E-box binding 7/1273 59/18639 0.11864406779661 1.73716164938022 0.105984554977716 0.495076579471301 GO:0008013 beta-catenin binding 11/1273 106/18639 0.10377358490566 1.51943114615601 0.108086328840041 0.495076579471301 GO:0035173 histone kinase activity 31/1273 360/18639 0.0861111111111111 1.26082089552239 0.10856034345885 0.495076579471301 GO:0004364 glutathione transferase activity 4/1273 27/18639 0.148148148148148 2.16915422885572 0.108814179586027 0.495076579471301 GO:0015252 proton channel activity 4/1273 27/18639 0.148148148148148 2.16915422885572 0.108814179586027 0.495076579471301 GO:0045296 cadherin binding 29/1273 334/18639 0.0868263473053892 1.27129323442667 0.109051368493272 0.495076579471301 GO:0004867 serine-type endopeptidase inhibitor activity 10/1273 95/18639 0.105263157894737 1.54124116260801 0.113401679711622 0.495076579471301 GO:0019888 protein phosphatase regulator activity 11/1273 107/18639 0.102803738317757 1.50523085507044 0.113475927924144 0.495076579471301 GO:0005501 retinoid binding 5/1273 38/18639 0.131578947368421 1.92655145326002 0.114555477126576 0.495076579471301 GO:0019840 isoprenoid binding 5/1273 38/18639 0.131578947368421 1.92655145326002 0.114555477126576 0.495076579471301 GO:0019903 protein phosphatase binding 14/1273 144/18639 0.0972222222222222 1.42350746268657 0.115139527614205 0.495076579471301 GO:0001222 transcription corepressor binding 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005004 GPI-linked ephrin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005008 hepatocyte growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005009 insulin receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005011 macrophage colony-stimulating factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0005020 stem cell factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0008288 boss receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0036332 placental growth factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0038062 protein tyrosine kinase collagen receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0060175 brain-derived neurotrophic factor receptor activity 6/1273 49/18639 0.122448979591837 1.79287237282973 0.115197874447616 0.495076579471301 GO:0004860 protein kinase inhibitor activity 9/1273 84/18639 0.107142857142857 1.56876332622601 0.118745978948855 0.502340506534381 GO:0045499 chemorepellent activity 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.502340506534381 GO:0046625 sphingolipid binding 4/1273 28/18639 0.142857142857143 2.09168443496802 0.120462389385098 0.502340506534381 GO:0004706 JUN kinase kinase kinase activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.502340506534381 GO:0030228 lipoprotein particle receptor activity 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.502340506534381 GO:0031690 adrenergic receptor binding 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.502340506534381 GO:0034185 apolipoprotein binding 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.502340506534381 GO:1990381 ubiquitin-specific protease binding 3/1273 18/18639 0.166666666666667 2.44029850746269 0.120598828900221 0.502340506534381 GO:0005007 fibroblast growth factor receptor activity 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.511747611740295 GO:0048020 CCR chemokine receptor binding 6/1273 50/18639 0.12 1.75701492537313 0.123802284650007 0.511747611740295 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/1273 39/18639 0.128205128205128 1.87715269804822 0.124450598540083 0.512471476117528 GO:0003785 actin monomer binding 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.534297902083404 GO:0035250 UDP-galactosyltransferase activity 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.534297902083404 GO:0099604 ligand-gated calcium channel activity 4/1273 29/18639 0.137931034482759 2.01955738548636 0.132618836908376 0.534297902083404 GO:0005010 insulin-like growth factor receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.534297902083404 GO:0005030 neurotrophin receptor activity 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.534297902083404 GO:0030544 Hsp70 protein binding 6/1273 51/18639 0.117647058823529 1.7225636523266 0.132711113259867 0.534297902083404 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1273 40/18639 0.125 1.83022388059702 0.134724926541952 0.53840256621747 GO:0071855 neuropeptide receptor binding 5/1273 40/18639 0.125 1.83022388059702 0.134724926541952 0.53840256621747 GO:0008381 mechanosensitive monoatomic ion channel activity 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.540759885580941 GO:0034987 immunoglobulin receptor binding 3/1273 19/18639 0.157894736842105 2.31186174391202 0.136313433761401 0.540759885580941 GO:0031406 carboxylic acid binding 17/1273 187/18639 0.0909090909090909 1.33107191316147 0.139566333991172 0.550582132967422 GO:0043022 ribosome binding 11/1273 112/18639 0.0982142857142857 1.43803304904051 0.142657498375056 0.550582132967422 GO:0004382 GDP phosphatase activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0004955 prostaglandin receptor activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0008140 cAMP response element binding protein binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0015279 store-operated calcium channel activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0019911 structural constituent of myelin sheath 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0030957 Tat protein binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0050815 phosphoserine residue binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0070513 death domain binding 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0140135 mechanosensitive monoatomic cation channel activity 2/1273 10/18639 0.2 2.92835820895522 0.145722007169697 0.550582132967422 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/1273 88/18639 0.102272727272727 1.49745590230665 0.145906807166805 0.550582132967422 GO:0016757 glycosyltransferase activity 23/1273 267/18639 0.0861423220973783 1.26127788026161 0.148897608555078 0.55864550916855 GO:0043177 organic acid binding 17/1273 189/18639 0.0899470899470899 1.31698649609097 0.149075302077295 0.55864550916855 GO:0005003 ephrin receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.561542820166119 GO:0005005 transmembrane-ephrin receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.561542820166119 GO:0038064 collagen receptor activity 6/1273 53/18639 0.113207547169811 1.65756125035201 0.151403973673598 0.561542820166119 GO:0043024 ribosomal small subunit binding 3/1273 20/18639 0.15 2.19626865671642 0.152678883601825 0.564338672152822 GO:0019902 phosphatase binding 17/1273 190/18639 0.0894736842105263 1.31005498821681 0.153960554510634 0.56714040998305 GO:0005184 neuropeptide hormone activity 4/1273 31/18639 0.129032258064516 1.88926336061627 0.15833441812703 0.581275168920586 GO:0015485 cholesterol binding 6/1273 54/18639 0.111111111111111 1.62686567164179 0.161167098282305 0.581534951967945 GO:0050661 NADP binding 6/1273 54/18639 0.111111111111111 1.62686567164179 0.161167098282305 0.581534951967945 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 12/1273 128/18639 0.09375 1.37266791044776 0.164581104594367 0.581534951967945 GO:0048156 tau protein binding 5/1273 43/18639 0.116279069767442 1.70253384241583 0.167658954282084 0.581534951967945 GO:0072341 modified amino acid binding 9/1273 91/18639 0.0989010989010989 1.44808922420863 0.168145498911478 0.581534951967945 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.581534951967945 GO:0035613 RNA stem-loop binding 3/1273 21/18639 0.142857142857143 2.09168443496802 0.169622399441769 0.581534951967945 GO:0002162 dystroglycan binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0003953 NAD+ nucleosidase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0004954 prostanoid receptor activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0008199 ferric iron binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0019864 IgG binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0032050 clathrin heavy chain binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0047676 arachidonate-CoA ligase activity 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0048185 activin binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0050998 nitric-oxide synthase binding 2/1273 11/18639 0.181818181818182 2.66214382632293 0.170402072490928 0.581534951967945 GO:0033293 monocarboxylic acid binding 8/1273 79/18639 0.10126582278481 1.48271301719252 0.170435275526267 0.581534951967945 GO:0035591 signaling adaptor activity 12/1273 129/18639 0.0930232558139535 1.36202707393266 0.17095875192406 0.581534951967945 GO:0016500 protein-hormone receptor activity 7/1273 67/18639 0.104477611940299 1.52973936288706 0.171683105049988 0.581534951967945 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 7/1273 67/18639 0.104477611940299 1.52973936288706 0.171683105049988 0.581534951967945 GO:0008378 galactosyltransferase activity 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.581534951967945 GO:0051059 NF-kappaB binding 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.581534951967945 GO:0160041 neuropeptide activity 4/1273 32/18639 0.125 1.83022388059702 0.171829348688589 0.581534951967945 GO:0019208 phosphatase regulator activity 11/1273 117/18639 0.094017094017094 1.37657864523536 0.175390709249769 0.589805725313181 GO:0052689 carboxylic ester hydrolase activity 9/1273 92/18639 0.0978260869565217 1.43234912394549 0.175892940911199 0.589805725313181 GO:0030695 GTPase regulator activity 39/1273 489/18639 0.0797546012269939 1.16775020602509 0.17590697070744 0.589805725313181 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 12/1273 130/18639 0.0923076923076923 1.35154994259472 0.177455944007083 0.593162923949601 GO:0060589 nucleoside-triphosphatase regulator activity 39/1273 490/18639 0.0795918367346939 1.16536704233932 0.179226044355073 0.595587402387639 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/1273 44/18639 0.113636363636364 1.66383989145183 0.179281157136076 0.595587402387639 GO:0016758 hexosyltransferase activity 17/1273 197/18639 0.0862944162436548 1.26350481097053 0.190509157423639 0.625193903134024 GO:0008237 metallopeptidase activity 16/1273 184/18639 0.0869565217391304 1.27319922128488 0.191206287384579 0.625193903134024 GO:0004875 complement receptor activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0005078 MAP-kinase scaffold activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0005095 GTPase inhibitor activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0031543 peptidyl-proline dioxygenase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0035259 nuclear glucocorticoid receptor binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0035497 cAMP response element binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0045295 gamma-catenin binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0070008 serine-type exopeptidase activity 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0097371 MDM2/MDM4 family protein binding 2/1273 12/18639 0.166666666666667 2.44029850746269 0.195697814554417 0.625193903134024 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/1273 34/18639 0.117647058823529 1.7225636523266 0.199926682821539 0.636825286752139 GO:0005496 steroid binding 10/1273 108/18639 0.0925925925925926 1.35572139303483 0.202499683716541 0.637840851610297 GO:0004180 carboxypeptidase activity 5/1273 46/18639 0.108695652173913 1.5914990266061 0.203377036430255 0.637840851610297 GO:0030276 clathrin binding 5/1273 46/18639 0.108695652173913 1.5914990266061 0.203377036430255 0.637840851610297 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1273 46/18639 0.108695652173913 1.5914990266061 0.203377036430255 0.637840851610297 GO:0015085 calcium ion transmembrane transporter activity 13/1273 147/18639 0.0884353741496599 1.29485226926592 0.204696432144441 0.637840851610297 GO:0005212 structural constituent of eye lens 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.637840851610297 GO:0016849 phosphorus-oxygen lyase activity 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.637840851610297 GO:0099186 structural constituent of postsynapse 3/1273 23/18639 0.130434782608696 1.90979883192732 0.204957171154555 0.637840851610297 GO:0004879 nuclear receptor activity 6/1273 59/18639 0.101694915254237 1.48899569946876 0.213675749871908 0.661173820317933 GO:0045309 protein phosphorylated amino acid binding 6/1273 59/18639 0.101694915254237 1.48899569946876 0.213675749871908 0.661173820317933 GO:0005154 epidermal growth factor receptor binding 4/1273 35/18639 0.114285714285714 1.67334754797441 0.214461023663108 0.661713073011812 GO:0008083 growth factor activity 14/1273 162/18639 0.0864197530864197 1.2653399668325 0.21731476465353 0.665938611251432 GO:0004222 metalloendopeptidase activity 10/1273 110/18639 0.0909090909090909 1.33107191316147 0.218338955879522 0.665938611251432 GO:0002161 aminoacyl-tRNA editing activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0005172 vascular endothelial growth factor receptor binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0008035 high-density lipoprotein particle binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0032396 inhibitory MHC class I receptor activity 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0035325 Toll-like receptor binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0070700 BMP receptor binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0071837 HMG box domain binding 2/1273 13/18639 0.153846153846154 2.25258323765786 0.221410220256048 0.665938611251432 GO:0030552 cAMP binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.665938611251432 GO:0035035 histone acetyltransferase binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.665938611251432 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1273 24/18639 0.125 1.83022388059702 0.223209340613361 0.665938611251432 GO:0098531 ligand-modulated transcription factor activity 6/1273 60/18639 0.1 1.46417910447761 0.224825478715367 0.668917564419622 GO:0005085 guanyl-nucleotide exchange factor activity 19/1273 230/18639 0.0826086956521739 1.20953926022064 0.226130361251215 0.670956660917988 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/1273 48/18639 0.104166666666667 1.52518656716418 0.228473857341257 0.675298970787728 GO:0043021 ribonucleoprotein complex binding 15/1273 177/18639 0.0847457627118644 1.2408297495573 0.228840925465463 0.675298970787728 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1273 86/18639 0.0930232558139535 1.36202707393266 0.23291827072857 0.685463280432178 GO:0030295 protein kinase activator activity 12/1273 139/18639 0.0863309352517986 1.26403951465693 0.240849860410785 0.701297929116769 GO:0070851 growth factor receptor binding 12/1273 139/18639 0.0863309352517986 1.26403951465693 0.240849860410785 0.701297929116769 GO:0001848 complement binding 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.701297929116769 GO:0003707 nuclear steroid receptor activity 3/1273 25/18639 0.12 1.75701492537313 0.241762347968895 0.701297929116769 GO:0008081 phosphoric diester hydrolase activity 8/1273 87/18639 0.0919540229885057 1.34637159032424 0.242444931343082 0.701297929116769 GO:0030551 cyclic nucleotide binding 4/1273 37/18639 0.108108108108108 1.58289632916499 0.244330501307025 0.701297929116769 GO:0008331 high voltage-gated calcium channel activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0008559 ABC-type xenobiotic transporter activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0016530 metallochaperone activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0019763 immunoglobulin receptor activity 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0019992 diacylglycerol binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0034236 protein kinase A catalytic subunit binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0043176 amine binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0071933 Arp2/3 complex binding 2/1273 14/18639 0.142857142857143 2.09168443496802 0.247364551175074 0.701297929116769 GO:0004519 endonuclease activity 11/1273 127/18639 0.0866141732283465 1.26818662592549 0.25008913795681 0.707171113334793 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 37/1273 484/18639 0.0764462809917355 1.11931047243123 0.259838377842177 0.727197425586588 GO:0008143 poly(A) binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.727197425586588 GO:0030507 spectrin binding 3/1273 26/18639 0.115384615384615 1.6894374282434 0.260552748811083 0.727197425586588 GO:0008238 exopeptidase activity 9/1273 102/18639 0.0882352941176471 1.29192273924495 0.26124955607139 0.727197425586588 GO:0017022 myosin binding 7/1273 76/18639 0.0921052631578947 1.34858601728201 0.26143357868725 0.727197425586588 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/1273 89/18639 0.0898876404494382 1.31611604896864 0.261871649103204 0.727197425586588 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/1273 89/18639 0.0898876404494382 1.31611604896864 0.261871649103204 0.727197425586588 GO:0140793 histone H2AXY142 phosphatase activity 8/1273 90/18639 0.0888888888888889 1.30149253731343 0.271755480230156 0.736569206350674 GO:0000774 adenyl-nucleotide exchange factor activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0004467 long-chain fatty acid-CoA ligase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0004953 icosanoid receptor activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0005523 tropomyosin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0015929 hexosaminidase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0016846 carbon-sulfur lyase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0031005 filamin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0048531 beta-1,3-galactosyltransferase activity 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0051371 muscle alpha-actinin binding 2/1273 15/18639 0.133333333333333 1.95223880597015 0.273407960252051 0.736569206350674 GO:0140297 DNA-binding transcription factor binding 37/1273 488/18639 0.0758196721311475 1.1101357964277 0.276559867764299 0.743211753818202 GO:0008266 poly(U) RNA binding 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.745616344264149 GO:0008320 protein transmembrane transporter activity 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.745616344264149 GO:0035255 ionotropic glutamate receptor binding 3/1273 27/18639 0.111111111111111 1.62686567164179 0.279520069964215 0.745616344264149 GO:0005262 calcium channel activity 11/1273 131/18639 0.083969465648855 1.22946337017204 0.282748562662502 0.752375167969262 GO:0001216 DNA-binding transcription activator activity 37/1273 491/18639 0.0753564154786151 1.10335288932121 0.289374337415072 0.767700525416144 GO:0004532 RNA exonuclease activity 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.767700525416144 GO:0071949 FAD binding 4/1273 40/18639 0.1 1.46417910447761 0.290634547941476 0.767700525416144 GO:0017046 peptide hormone binding 5/1273 53/18639 0.0943396226415094 1.38130104196001 0.294509205516991 0.768384189539194 GO:0008235 metalloexopeptidase activity 6/1273 66/18639 0.0909090909090909 1.33107191316147 0.295091653491148 0.768384189539194 GO:0051019 mitogen-activated protein kinase binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.768384189539194 GO:0097718 disordered domain specific binding 3/1273 28/18639 0.107142857142857 1.56876332622601 0.298606991633709 0.768384189539194 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0005149 interleukin-1 receptor binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0005521 lamin binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0008142 oxysterol binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0008296 3'-5'-DNA exonuclease activity 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/1273 16/18639 0.125 1.83022388059702 0.299407320392927 0.768384189539194 GO:0001530 lipopolysaccharide binding 4/1273 41/18639 0.0975609756097561 1.42846741900255 0.306339627923131 0.78062545186059 GO:0017080 sodium channel regulator activity 4/1273 41/18639 0.0975609756097561 1.42846741900255 0.306339627923131 0.78062545186059 GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/1273 41/18639 0.0975609756097561 1.42846741900255 0.306339627923131 0.78062545186059 GO:0019209 kinase activator activity 12/1273 148/18639 0.0810810810810811 1.18717224687374 0.311384471301898 0.791618268591444 GO:0030971 receptor tyrosine kinase binding 7/1273 81/18639 0.0864197530864197 1.2653399668325 0.316101005332854 0.798736437007603 GO:0004629 phospholipase C activity 3/1273 29/18639 0.103448275862069 1.51466803911477 0.317759471025094 0.798736437007603 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1273 29/18639 0.103448275862069 1.51466803911477 0.317759471025094 0.798736437007603 GO:0008307 structural constituent of muscle 4/1273 42/18639 0.0952380952380952 1.39445628997868 0.322128375115932 0.798736437007603 GO:0004550 nucleoside diphosphate kinase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0015278 intracellularly gated calcium channel activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0016018 cyclosporin A binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0016805 dipeptidase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0019198 transmembrane receptor protein phosphatase activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0030548 acetylcholine receptor regulator activity 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0036041 long-chain fatty acid binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0048038 quinone binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0070402 NADPH binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0070403 NAD+ binding 2/1273 17/18639 0.117647058823529 1.7225636523266 0.325247247202542 0.798736437007603 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.81998144187814 GO:0008187 poly-pyrimidine tract binding 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.81998144187814 GO:0033612 receptor serine/threonine kinase binding 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.81998144187814 GO:0098918 structural constituent of synapse 3/1273 30/18639 0.1 1.46417910447761 0.336926815914841 0.81998144187814 GO:0000400 four-way junction DNA binding 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.842217957650636 GO:0004970 glutamate-gated receptor activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.842217957650636 GO:0015280 ligand-gated sodium channel activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.842217957650636 GO:0070064 proline-rich region binding 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.842217957650636 GO:0099602 neurotransmitter receptor regulator activity 2/1273 18/18639 0.111111111111111 1.62686567164179 0.350828299490332 0.842217957650636 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 26/1273 349/18639 0.0744985673352436 1.09079245605782 0.351145423575898 0.842217957650636 GO:0004725 protein tyrosine phosphatase activity 8/1273 98/18639 0.0816326530612245 1.19524824855315 0.353821144395001 0.842217957650636 GO:0001046 core promoter sequence-specific DNA binding 4/1273 44/18639 0.0909090909090909 1.33107191316147 0.353840416187479 0.842217957650636 GO:0019205 nucleobase-containing compound kinase activity 4/1273 44/18639 0.0909090909090909 1.33107191316147 0.353840416187479 0.842217957650636 GO:0043014 alpha-tubulin binding 4/1273 44/18639 0.0909090909090909 1.33107191316147 0.353840416187479 0.842217957650636 GO:0004518 nuclease activity 16/1273 209/18639 0.076555023923445 1.12090266371492 0.354867919263642 0.842811308251149 GO:0043130 ubiquitin binding 8/1273 100/18639 0.08 1.17134328358209 0.374864269293867 0.875868313862792 GO:0022884 macromolecule transmembrane transporter activity 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.875868313862792 GO:0030515 snoRNA binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.875868313862792 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.875868313862792 GO:0042910 xenobiotic transmembrane transporter activity 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.875868313862792 GO:0070717 poly-purine tract binding 3/1273 32/18639 0.09375 1.37266791044776 0.375120236400845 0.875868313862792 GO:0030506 ankyrin binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.875868313862792 GO:0050145 nucleoside monophosphate kinase activity 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.875868313862792 GO:0097001 ceramide binding 2/1273 19/18639 0.105263157894737 1.54124116260801 0.376065342517265 0.875868313862792 GO:0005543 phospholipid binding 36/1273 497/18639 0.0724346076458753 1.06057238956125 0.380950355964331 0.885341707101653 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1273 33/18639 0.0909090909090909 1.33107191316147 0.394061785926654 0.911216496708925 GO:0019239 deaminase activity 3/1273 33/18639 0.0909090909090909 1.33107191316147 0.394061785926654 0.911216496708925 GO:0004197 cysteine-type endopeptidase activity 7/1273 88/18639 0.0795454545454545 1.16468792401628 0.395303457037655 0.911216496708925 GO:0051020 GTPase binding 23/1273 315/18639 0.073015873015873 1.06908315565032 0.400571852136349 0.911216496708925 GO:0001972 retinoic acid binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0016004 phospholipase activator activity 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0031418 L-ascorbic acid binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0042288 MHC class I protein binding 2/1273 20/18639 0.1 1.46417910447761 0.400886060174536 0.911216496708925 GO:0001784 phosphotyrosine residue binding 4/1273 47/18639 0.0851063829787234 1.24610987615116 0.401339121819166 0.911216496708925 GO:0140098 catalytic activity, acting on RNA 28/1273 387/18639 0.0723514211886305 1.05935439083652 0.403486696439512 0.913035045338321 GO:0000287 magnesium ion binding 17/1273 230/18639 0.0739130434782609 1.08221933809215 0.403826211188417 0.913035045338321 GO:0003823 antigen binding 13/1273 174/18639 0.0747126436781609 1.09392691713845 0.410116970813891 0.9167481055439 GO:0008376 acetylgalactosaminyltransferase activity 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.9167481055439 GO:0019825 oxygen binding 3/1273 34/18639 0.0882352941176471 1.29192273924495 0.412849053969084 0.9167481055439 GO:0008188 neuropeptide receptor activity 4/1273 48/18639 0.0833333333333333 1.22014925373134 0.417054145862613 0.9167481055439 GO:0001846 opsonin binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.9167481055439 GO:0008373 sialyltransferase activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.9167481055439 GO:0061891 calcium ion sensor activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.9167481055439 GO:0070182 DNA polymerase binding 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.9167481055439 GO:0072542 protein phosphatase activator activity 2/1273 21/18639 0.0952380952380952 1.39445628997868 0.425229603409565 0.9167481055439 GO:0000175 3'-5'-RNA exonuclease activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.9167481055439 GO:0016229 steroid dehydrogenase activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.9167481055439 GO:0043015 gamma-tubulin binding 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.9167481055439 GO:0061631 ubiquitin conjugating enzyme activity 3/1273 35/18639 0.0857142857142857 1.25501066098081 0.43144793181027 0.9167481055439 GO:0016763 pentosyltransferase activity 4/1273 49/18639 0.0816326530612245 1.19524824855315 0.432672636328212 0.9167481055439 GO:0035254 glutamate receptor binding 4/1273 49/18639 0.0816326530612245 1.19524824855315 0.432672636328212 0.9167481055439 GO:0008093 cytoskeletal anchor activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0008970 phospholipase A1 activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0016881 acid-amino acid ligase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0033691 sialic acid binding 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0034062 5'-3' RNA polymerase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0050321 tau-protein kinase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0061133 endopeptidase activator activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0097747 RNA polymerase activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0140784 metal ion sensor activity 2/1273 22/18639 0.0909090909090909 1.33107191316147 0.449045363250737 0.9167481055439 GO:0140789 histone phosphatase activity 10/1273 136/18639 0.0735294117647059 1.07660228270413 0.451961400593942 0.9167481055439 GO:0051213 dioxygenase activity 7/1273 93/18639 0.0752688172043011 1.10207029369283 0.452064077181705 0.9167481055439 GO:0051219 phosphoprotein binding 7/1273 93/18639 0.0752688172043011 1.10207029369283 0.452064077181705 0.9167481055439 GO:0120013 lipid transfer activity 5/1273 65/18639 0.0769230769230769 1.12629161882893 0.459421089266717 0.9167481055439 GO:0005048 signal sequence binding 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.9167481055439 GO:0016597 amino acid binding 4/1273 51/18639 0.0784313725490196 1.14837576821773 0.463539116739026 0.9167481055439 GO:0042805 actinin binding 3/1273 37/18639 0.0810810810810811 1.18717224687374 0.467959496193981 0.9167481055439 GO:0005283 amino acid:sodium symporter activity 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.9167481055439 GO:0043274 phospholipase binding 2/1273 23/18639 0.0869565217391304 1.27319922128488 0.472291857736087 0.9167481055439 GO:0005080 protein kinase C binding 4/1273 52/18639 0.0769230769230769 1.12629161882893 0.47874998380504 0.9167481055439 GO:0030159 signaling receptor complex adaptor activity 4/1273 52/18639 0.0769230769230769 1.12629161882893 0.47874998380504 0.9167481055439 GO:0140101 catalytic activity, acting on a tRNA 10/1273 139/18639 0.0719424460431655 1.05336626221411 0.47978384868608 0.9167481055439 GO:0005506 iron ion binding 11/1273 154/18639 0.0714285714285714 1.04584221748401 0.483956511433012 0.9167481055439 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1273 38/18639 0.0789473684210526 1.15593087195601 0.485819040049698 0.9167481055439 GO:0005096 GTPase activator activity 19/1273 271/18639 0.0701107011070111 1.02654623561161 0.487226459387883 0.9167481055439 GO:1902936 phosphatidylinositol bisphosphate binding 8/1273 111/18639 0.0720720720720721 1.05526421944332 0.490417042434831 0.9167481055439 GO:0051018 protein kinase A binding 4/1273 53/18639 0.0754716981132075 1.10504083356801 0.493790047338758 0.9167481055439 GO:0004806 triacylglycerol lipase activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0030215 semaphorin receptor binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0050431 transforming growth factor beta binding 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0060229 lipase activator activity 2/1273 24/18639 0.0833333333333333 1.22014925373134 0.494935722929062 0.9167481055439 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 17/1273 243/18639 0.0699588477366255 1.02432283029298 0.495408468943906 0.9167481055439 GO:1901981 phosphatidylinositol phosphate binding 13/1273 185/18639 0.0702702702702703 1.02888261395724 0.499127375151024 0.9167481055439 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1273 39/18639 0.0769230769230769 1.12629161882893 0.503383661237046 0.9167481055439 GO:0005254 chloride channel activity 6/1273 83/18639 0.072289156626506 1.05844272612839 0.503973148348105 0.9167481055439 GO:0001094 TFIID-class transcription factor complex binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0003796 lysozyme activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0004935 adrenergic receptor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0005031 tumor necrosis factor receptor activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0005345 purine nucleobase transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0005381 iron ion transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0008239 dipeptidyl-peptidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0008401 retinoic acid 4-hydroxylase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0015187 glycine transmembrane transporter activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0016783 sulfurtransferase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0033204 ribonuclease P RNA binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0035256 G protein-coupled glutamate receptor binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0035374 chondroitin sulfate binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0043121 neurotrophin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0043295 glutathione binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0051378 serotonin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0070097 delta-catenin binding 1/1273 10/18639 0.1 1.46417910447761 0.507172429236694 0.9167481055439 GO:0042626 ATPase-coupled transmembrane transporter activity 7/1273 98/18639 0.0714285714285714 1.04584221748401 0.507707974684204 0.9167481055439 GO:0003925 G protein activity 4/1273 54/18639 0.0740740740740741 1.08457711442786 0.508644007686666 0.9167481055439 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/1273 54/18639 0.0740740740740741 1.08457711442786 0.508644007686666 0.9167481055439 GO:0004676 3-phosphoinositide-dependent protein kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0004711 ribosomal protein S6 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0035175 histone H3S10 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0035979 histone H2AXS139 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0044022 histone H3S28 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0044023 histone H4S1 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0044024 histone H2AS1 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0044025 histone H2BS14 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0072354 histone H3T3 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0072371 histone H2AS121 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0072518 Rho-dependent protein serine/threonine kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0140823 histone H2BS36 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0140855 histone H3S57 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0140995 histone H2A kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0140997 histone H4 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0140998 histone H2B kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:1990244 histone H2AT120 kinase activity 17/1273 245/18639 0.0693877551020408 1.01596101127018 0.509340622391869 0.9167481055439 GO:0042578 phosphoric ester hydrolase activity 25/1273 363/18639 0.068870523415978 1.00838781300111 0.512842763295455 0.9167481055439 GO:0004677 DNA-dependent protein kinase activity 17/1273 246/18639 0.0691056910569106 1.01183108846014 0.516274444387901 0.9167481055439 GO:0140857 histone H3T45 kinase activity 17/1273 246/18639 0.0691056910569106 1.01183108846014 0.516274444387901 0.9167481055439 GO:0000030 mannosyltransferase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0005251 delayed rectifier potassium channel activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0005537 D-mannose binding 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0015271 outward rectifier potassium channel activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0015645 fatty acid ligase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0015662 P-type ion transporter activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0019211 phosphatase activator activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0120515 fatty acid-CoA ligase activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0140358 P-type transmembrane transporter activity 2/1273 25/18639 0.08 1.17134328358209 0.516950799012555 0.9167481055439 GO:0004177 aminopeptidase activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.9167481055439 GO:0061791 GTPase motor activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.9167481055439 GO:1990606 membrane scission GTPase motor activity 3/1273 40/18639 0.075 1.09813432835821 0.520633589342093 0.9167481055439 GO:0035402 histone H3T11 kinase activity 17/1273 247/18639 0.0688259109311741 1.00773460632062 0.523184192013136 0.9167481055439 GO:0035403 histone H3T6 kinase activity 17/1273 247/18639 0.0688259109311741 1.00773460632062 0.523184192013136 0.9167481055439 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1273 70/18639 0.0714285714285714 1.04584221748401 0.525554746759389 0.9167481055439 GO:0004679 AMP-activated protein kinase activity 17/1273 248/18639 0.0685483870967742 1.0036711603274 0.530067982660064 0.9167481055439 GO:0001221 transcription coregulator binding 8/1273 115/18639 0.0695652173913043 1.0185593770279 0.531175508416634 0.9167481055439 GO:0004721 phosphoprotein phosphatase activity 12/1273 175/18639 0.0685714285714286 1.00400852878465 0.537293282939259 0.9167481055439 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.9167481055439 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.9167481055439 GO:0042169 SH2 domain binding 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.9167481055439 GO:0140318 protein transporter activity 3/1273 41/18639 0.0731707317073171 1.07135056425191 0.537551533664643 0.9167481055439 GO:0004529 DNA exonuclease activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0005112 Notch binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0008066 glutamate receptor activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0008198 ferrous iron binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0030247 polysaccharide binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0034237 protein kinase A regulatory subunit binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0050681 nuclear androgen receptor binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0070006 metalloaminopeptidase activity 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0070412 R-SMAD binding 2/1273 26/18639 0.0769230769230769 1.12629161882893 0.538317303196011 0.9167481055439 GO:0050660 flavin adenine dinucleotide binding 6/1273 86/18639 0.0697674418604651 1.0215203054495 0.539205418708581 0.9167481055439 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0001851 complement component C3b binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0008172 S-methyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0008432 JUN kinase binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0008503 benzodiazepine receptor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0010854 adenylate cyclase regulator activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0015205 nucleobase transmembrane transporter activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0016594 glycine binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0031731 CCR6 chemokine receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0032794 GTPase activating protein binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0034056 estrogen response element binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0034511 U3 snoRNA binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0034713 type I transforming growth factor beta receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0035252 UDP-xylosyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0042285 xylosyltransferase activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0070697 activin receptor binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0097493 structural molecule activity conferring elasticity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0140031 phosphorylation-dependent protein binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:1900750 oligopeptide binding 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:1990948 ubiquitin ligase inhibitor activity 1/1273 11/18639 0.0909090909090909 1.33107191316147 0.540849464911271 0.9167481055439 GO:0019894 kinesin binding 3/1273 42/18639 0.0714285714285714 1.04584221748401 0.554122545860698 0.9167481055439 GO:0031492 nucleosomal DNA binding 3/1273 42/18639 0.0714285714285714 1.04584221748401 0.554122545860698 0.9167481055439 GO:0035198 miRNA binding 3/1273 42/18639 0.0714285714285714 1.04584221748401 0.554122545860698 0.9167481055439 GO:0005516 calmodulin binding 14/1273 207/18639 0.0676328502415459 0.990266060999351 0.554959644135778 0.9167481055439 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.9167481055439 GO:0016405 CoA-ligase activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.9167481055439 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.9167481055439 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/1273 27/18639 0.0740740740740741 1.08457711442786 0.559021081854555 0.9167481055439 GO:0031267 small GTPase binding 19/1273 283/18639 0.0671378091872792 0.983017773324192 0.565263654274045 0.9167481055439 GO:0008408 3'-5' exonuclease activity 4/1273 58/18639 0.0689655172413793 1.00977869274318 0.565936345492053 0.9167481055439 GO:0061980 regulatory RNA binding 4/1273 58/18639 0.0689655172413793 1.00977869274318 0.565936345492053 0.9167481055439 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1273 43/18639 0.0697674418604651 1.0215203054495 0.570333882352448 0.9167481055439 GO:0004032 aldose reductase (NADPH) activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0004300 enoyl-CoA hydratase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0004526 ribonuclease P activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0005025 transforming growth factor beta receptor activity, type I 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0005026 transforming growth factor beta receptor activity, type II 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0005049 nuclear export signal receptor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0005165 neurotrophin receptor binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0015166 polyol transmembrane transporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0015368 calcium:monoatomic cation antiporter activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0016361 activin receptor activity, type I 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0016362 activin receptor activity, type II 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0016801 hydrolase activity, acting on ether bonds 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0016803 ether hydrolase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0016840 carbon-nitrogen lyase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0017002 activin receptor activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0034452 dynactin binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0035251 UDP-glucosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0042301 phosphate ion binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0043047 single-stranded telomeric DNA binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:1990459 transferrin receptor binding 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:1990817 poly(A) RNA polymerase activity 1/1273 12/18639 0.0833333333333333 1.22014925373134 0.572226887670985 0.9167481055439 GO:0046966 nuclear thyroid hormone receptor binding 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.91744073743926 GO:0051393 alpha-actinin binding 2/1273 28/18639 0.0714285714285714 1.04584221748401 0.579052934948466 0.91744073743926 GO:0015459 potassium channel regulator activity 4/1273 59/18639 0.0677966101694915 0.992663799645839 0.579673338513842 0.91744073743926 GO:0032182 ubiquitin-like protein binding 8/1273 120/18639 0.0666666666666667 0.976119402985075 0.580301714341846 0.91744073743926 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 12/1273 181/18639 0.0662983425414365 0.970726478106704 0.585182738966436 0.91744073743926 GO:0106310 protein serine kinase activity 24/1273 361/18639 0.0664819944598338 0.97341547112085 0.585360642763746 0.91744073743926 GO:0001223 transcription coactivator binding 3/1273 44/18639 0.0681818181818182 0.998303934871099 0.586174867681593 0.91744073743926 GO:0003725 double-stranded RNA binding 5/1273 75/18639 0.0666666666666667 0.976119402985075 0.587894059840508 0.91744073743926 GO:0019003 GDP binding 5/1273 75/18639 0.0666666666666667 0.976119402985075 0.587894059840508 0.91744073743926 GO:0016779 nucleotidyltransferase activity 9/1273 136/18639 0.0661764705882353 0.968942054433714 0.58811783475166 0.91744073743926 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/1273 60/18639 0.0666666666666667 0.976119402985075 0.593157753481751 0.91744073743926 GO:0016922 nuclear receptor binding 9/1273 137/18639 0.0656934306569343 0.961869484693322 0.597037337212412 0.91744073743926 GO:0004181 metallocarboxypeptidase activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.91744073743926 GO:0005416 amino acid:monoatomic cation symporter activity 2/1273 29/18639 0.0689655172413793 1.00977869274318 0.598408006350198 0.91744073743926 GO:0004465 lipoprotein lipase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0004535 poly(A)-specific ribonuclease activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0004993 G protein-coupled serotonin receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0005035 death receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0008253 5'-nucleotidase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0019104 DNA N-glycosylase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0031432 titin binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0045159 myosin II binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0070123 transforming growth factor beta receptor activity, type III 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0071714 icosanoid transmembrane transporter activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0097157 pre-mRNA intronic binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0140333 glycerophospholipid flippase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:1901338 catecholamine binding 1/1273 13/18639 0.0769230769230769 1.12629161882893 0.601461609955563 0.91744073743926 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/1273 61/18639 0.0655737704918033 0.96011744555909 0.606382374550502 0.923645726635997 GO:0016769 transferase activity, transferring nitrogenous groups 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.936716630244162 GO:0051721 protein phosphatase 2A binding 2/1273 30/18639 0.0666666666666667 0.976119402985075 0.617085234238437 0.936716630244162 GO:0005545 1-phosphatidylinositol binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0008195 phosphatidate phosphatase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0008494 translation activator activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0061783 peptidoglycan muralytic activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0070742 C2H2 zinc finger domain binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0098599 palmitoyl hydrolase activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0098821 BMP receptor activity 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0098847 sequence-specific single stranded DNA binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:1990825 sequence-specific mRNA binding 1/1273 14/18639 0.0714285714285714 1.04584221748401 0.62869984524637 0.936716630244162 GO:0046982 protein heterodimerization activity 24/1273 369/18639 0.0650406504065041 0.952311612668366 0.628960609769129 0.936716630244162 GO:0008234 cysteine-type peptidase activity 12/1273 187/18639 0.0641711229946524 0.939580173996329 0.630815759517928 0.936716630244162 GO:0043495 protein-membrane adaptor activity 3/1273 47/18639 0.0638297872340425 0.934582407113369 0.631397174587478 0.936716630244162 GO:0099095 ligand-gated monoatomic anion channel activity 3/1273 47/18639 0.0638297872340425 0.934582407113369 0.631397174587478 0.936716630244162 GO:0140359 ABC-type transporter activity 3/1273 47/18639 0.0638297872340425 0.934582407113369 0.631397174587478 0.936716630244162 GO:0046332 SMAD binding 5/1273 79/18639 0.0632911392405063 0.926695635745324 0.634372998929414 0.936848160388882 GO:0016878 acid-thiol ligase activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.936848160388882 GO:0047499 calcium-independent phospholipase A2 activity 2/1273 31/18639 0.0645161290322581 0.944631680308137 0.635086856208135 0.936848160388882 GO:0004536 DNA nuclease activity 4/1273 64/18639 0.0625 0.915111940298508 0.644439876930865 0.936848160388882 GO:0042826 histone deacetylase binding 8/1273 127/18639 0.062992125984252 0.92231754612763 0.644712099583649 0.936848160388882 GO:0000049 tRNA binding 5/1273 80/18639 0.0625 0.915111940298508 0.645476338176119 0.936848160388882 GO:0038187 pattern recognition receptor activity 3/1273 48/18639 0.0625 0.915111940298508 0.645686709835802 0.936848160388882 GO:0140693 molecular condensate scaffold activity 3/1273 48/18639 0.0625 0.915111940298508 0.645686709835802 0.936848160388882 GO:0015106 bicarbonate transmembrane transporter activity 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.936848160388882 GO:0140142 nucleocytoplasmic carrier activity 2/1273 32/18639 0.0625 0.915111940298508 0.652417964195288 0.936848160388882 GO:0008242 omega peptidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0008252 nucleotidase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0015250 water channel activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0030553 cGMP binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0061578 K63-linked deubiquitinase activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0120283 protein serine/threonine kinase binding 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0140776 protein-containing complex destabilizing activity 1/1273 15/18639 0.0666666666666667 0.976119402985075 0.654077837031679 0.936848160388882 GO:0033192 calmodulin-dependent protein phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0140791 histone H2AXS140 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/1273 81/18639 0.0617283950617284 0.903814262023217 0.65636552735741 0.936848160388882 GO:0019843 rRNA binding 4/1273 65/18639 0.0615384615384615 0.901033295063146 0.656572256449826 0.936848160388882 GO:0030594 neurotransmitter receptor activity 6/1273 97/18639 0.0618556701030928 0.90567779658409 0.657578027297012 0.937048688898242 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 17/1273 268/18639 0.0634328358208955 0.928770327467142 0.659757776947802 0.938919411871839 GO:0035091 phosphatidylinositol binding 18/1273 284/18639 0.0633802816901408 0.928000840866092 0.663690914021292 0.943277243943647 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/1273 82/18639 0.0609756097560976 0.892792136876593 0.667037720087331 0.943410679700033 GO:0033549 MAP kinase phosphatase activity 5/1273 82/18639 0.0609756097560976 0.892792136876593 0.667037720087331 0.943410679700033 GO:0042923 neuropeptide binding 2/1273 33/18639 0.0606060606060606 0.887381275440977 0.669086104728748 0.943410679700033 GO:0003924 GTPase activity 21/1273 331/18639 0.0634441087613293 0.928935383505433 0.669542240841927 0.943410679700033 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/1273 83/18639 0.0602409638554217 0.882035605106995 0.677490577250102 0.943410679700033 GO:0003688 DNA replication origin binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0005024 transforming growth factor beta receptor activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0015562 efflux transmembrane transporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0017070 U6 snRNA binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0022841 potassium ion leak channel activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0022858 alanine transmembrane transporter activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0070411 I-SMAD binding 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0140327 flippase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0140328 floppase activity 1/1273 16/18639 0.0625 0.915111940298508 0.677722538140928 0.943410679700033 GO:0015020 glucuronosyltransferase activity 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.949005846784699 GO:0030332 cyclin binding 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.949005846784699 GO:0090482 vitamin transmembrane transporter activity 2/1273 34/18639 0.0588235294117647 0.861281826163301 0.685100920401227 0.949005846784699 GO:0003743 translation initiation factor activity 3/1273 51/18639 0.0588235294117647 0.861281826163301 0.686168720694197 0.949005846784699 GO:0004527 exonuclease activity 5/1273 84/18639 0.0595238095238095 0.871535181236674 0.687722244481342 0.949005846784699 GO:0017018 myosin phosphatase activity 5/1273 84/18639 0.0595238095238095 0.871535181236674 0.687722244481342 0.949005846784699 GO:0022804 active transmembrane transporter activity 29/1273 457/18639 0.0634573304157549 0.9291289722068 0.687875890790387 0.949005846784699 GO:0030145 manganese ion binding 4/1273 68/18639 0.0588235294117647 0.861281826163301 0.691270471823847 0.95064305337235 GO:0004549 tRNA-specific ribonuclease activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0008429 phosphatidylethanolamine binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0009881 photoreceptor activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0031489 myosin V binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0032977 membrane insertase activity 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0038191 neuropilin binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0045236 CXCR chemokine receptor binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0046965 nuclear retinoid X receptor binding 1/1273 17/18639 0.0588235294117647 0.861281826163301 0.699752243824578 0.95064305337235 GO:0004623 phospholipase A2 activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.95064305337235 GO:0005343 organic acid:sodium symporter activity 2/1273 35/18639 0.0571428571428571 0.836673773987207 0.700473828800679 0.95064305337235 GO:0019842 vitamin binding 9/1273 150/18639 0.06 0.878507462686567 0.703531319733874 0.953597520990971 GO:0015171 amino acid transmembrane transporter activity 6/1273 102/18639 0.0588235294117647 0.861281826163301 0.704648042814625 0.953618811503544 GO:0008146 sulfotransferase activity 3/1273 53/18639 0.0566037735849057 0.828780625176007 0.711172493816085 0.953618811503544 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1273 53/18639 0.0566037735849057 0.828780625176007 0.711172493816085 0.953618811503544 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1273 53/18639 0.0566037735849057 0.828780625176007 0.711172493816085 0.953618811503544 GO:0004722 protein serine/threonine phosphatase activity 6/1273 103/18639 0.058252427184466 0.852919866685988 0.713514810857078 0.953618811503544 GO:0005253 monoatomic anion channel activity 6/1273 103/18639 0.058252427184466 0.852919866685988 0.713514810857078 0.953618811503544 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.953618811503544 GO:0005484 SNAP receptor activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.953618811503544 GO:0016409 palmitoyltransferase activity 2/1273 36/18639 0.0555555555555556 0.813432835820896 0.715217735463809 0.953618811503544 GO:0001217 DNA-binding transcription repressor activity 17/1273 278/18639 0.0611510791366906 0.895361322881993 0.716899852211847 0.953618811503544 GO:0003746 translation elongation factor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0005372 water transmembrane transporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0008525 phosphatidylcholine transporter activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0016854 racemase and epimerase activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0017075 syntaxin-1 binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0035615 clathrin adaptor activity 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:1901611 phosphatidylglycerol binding 1/1273 18/18639 0.0555555555555556 0.813432835820896 0.720277181726592 0.953618811503544 GO:0140463 chromatin-protein adaptor activity 3/1273 54/18639 0.0555555555555556 0.813432835820896 0.72308593417664 0.955573110742634 GO:0015108 chloride transmembrane transporter activity 7/1273 121/18639 0.0578512396694215 0.847045762920933 0.727769608710465 0.955573110742634 GO:0140104 molecular carrier activity 15/1273 249/18639 0.0602409638554217 0.882035605106995 0.72979677627773 0.955573110742634 GO:0003727 single-stranded RNA binding 5/1273 89/18639 0.0561797752808989 0.8225725306054 0.735528910405107 0.955573110742634 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/1273 122/18639 0.0573770491803279 0.840102764864204 0.735591487999229 0.955573110742634 GO:0004497 monooxygenase activity 6/1273 106/18639 0.0566037735849057 0.828780625176007 0.739006286361256 0.955573110742634 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0008301 DNA binding, bending 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0008574 plus-end-directed microtubule motor activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0022821 solute:potassium antiporter activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0022840 leak channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0022842 narrow pore channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0042577 lipid phosphatase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0046527 glucosyltransferase activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0046624 sphingolipid transporter activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0099589 serotonin receptor activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0140036 ubiquitin-modified protein reader activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0141147 intracellularly calcium-gated channel activity 1/1273 19/18639 0.0526315789473684 0.770620581304006 0.739400061682666 0.955573110742634 GO:0000146 microfilament motor activity 2/1273 38/18639 0.0526315789473684 0.770620581304006 0.742876096466582 0.957779538658701 GO:0043531 ADP binding 2/1273 38/18639 0.0526315789473684 0.770620581304006 0.742876096466582 0.957779538658701 GO:0140597 protein carrier chaperone 11/1273 188/18639 0.0585106382978723 0.856700539853922 0.74455929364448 0.95880822237452 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/1273 56/18639 0.0535714285714286 0.784381663113006 0.745755952322873 0.959208665517424 GO:0048029 monosaccharide binding 4/1273 74/18639 0.0540540540540541 0.791448164582493 0.752977551796191 0.96138987677408 GO:0000217 DNA secondary structure binding 2/1273 39/18639 0.0512820512820513 0.750861079219288 0.755821633506017 0.96138987677408 GO:0001614 purinergic nucleotide receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0005326 neurotransmitter transmembrane transporter activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0010851 cyclase regulator activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0016408 C-acyltransferase activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0016502 nucleotide receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0016505 peptidase activator activity involved in apoptotic process 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0030742 GTP-dependent protein binding 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0061608 nuclear import signal receptor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0140664 ATP-dependent DNA damage sensor activity 1/1273 20/18639 0.05 0.732089552238806 0.75721658807783 0.96138987677408 GO:0004620 phospholipase activity 6/1273 109/18639 0.055045871559633 0.805970149253731 0.762835160606084 0.967389319597646 GO:0016791 phosphatase activity 16/1273 273/18639 0.0586080586080586 0.858126947679186 0.772169087979091 0.969956782532497 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0005123 death receptor binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0009975 cyclase activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0015125 bile acid transmembrane transporter activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0019200 carbohydrate kinase activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0036122 BMP binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0051428 peptide hormone receptor binding 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0140312 cargo adaptor activity 1/1273 21/18639 0.0476190476190476 0.697228144989339 0.773815937311244 0.969956782532497 GO:0036002 pre-mRNA binding 3/1273 59/18639 0.0508474576271186 0.744497849734379 0.776949267729403 0.97202375549257 GO:0008227 G protein-coupled amine receptor activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.97202375549257 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.97202375549257 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1273 41/18639 0.0487804878048781 0.714233709501274 0.780028075617613 0.97202375549257 GO:0003724 RNA helicase activity 4/1273 77/18639 0.051948051948052 0.760612521806552 0.780058068431167 0.97202375549257 GO:0004674 protein serine/threonine kinase activity 26/1273 433/18639 0.0600461893764434 0.87918375788494 0.78085010829043 0.97202375549257 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/1273 60/18639 0.05 0.732089552238806 0.786622505321384 0.976085638189308 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1273 60/18639 0.05 0.732089552238806 0.786622505321384 0.976085638189308 GO:0015377 chloride:monoatomic cation symporter activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.976085638189308 GO:0070034 telomerase RNA binding 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.976085638189308 GO:0140035 ubiquitin-like protein reader activity 1/1273 22/18639 0.0454545454545455 0.665535956580733 0.789281202742696 0.976085638189308 GO:0004520 DNA endonuclease activity 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.976085638189308 GO:0048487 beta-tubulin binding 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.976085638189308 GO:0051879 Hsp90 protein binding 2/1273 42/18639 0.0476190476190476 0.697228144989339 0.791323352105459 0.976085638189308 GO:0016298 lipase activity 7/1273 130/18639 0.0538461538461538 0.788404133180253 0.792505612326176 0.97643182952133 GO:0019905 syntaxin binding 3/1273 61/18639 0.0491803278688525 0.720088084169317 0.795945270706085 0.977595245100032 GO:0008186 ATP-dependent activity, acting on RNA 4/1273 79/18639 0.0506329113924051 0.741356508596259 0.796766991379258 0.977595245100032 GO:0005245 voltage-gated calcium channel activity 2/1273 43/18639 0.0465116279069767 0.681013536966331 0.802103326239753 0.977595245100032 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1273 43/18639 0.0465116279069767 0.681013536966331 0.802103326239753 0.977595245100032 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0005158 insulin receptor binding 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0017134 fibroblast growth factor binding 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0071617 lysophospholipid acyltransferase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0140103 catalytic activity, acting on a glycoprotein 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1273 23/18639 0.0434782608695652 0.63659961064244 0.803689809333906 0.977595245100032 GO:0015179 L-amino acid transmembrane transporter activity 3/1273 62/18639 0.0483870967741935 0.708473760231103 0.804925150151595 0.977595245100032 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/1273 132/18639 0.053030303030303 0.776458616010855 0.805184634006675 0.977595245100032 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.977670526316932 GO:0022835 transmitter-gated channel activity 3/1273 63/18639 0.0476190476190476 0.697228144989339 0.813569994099248 0.977670526316932 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0015295 solute:proton symporter activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0048027 mRNA 5'-UTR binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0050699 WW domain binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0070300 phosphatidic acid binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0070840 dynein complex binding 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0140612 DNA damage sensor activity 1/1273 24/18639 0.0416666666666667 0.610074626865672 0.81711390004716 0.977670526316932 GO:0000510 H3-H4 histone complex chaperone activity 8/1273 151/18639 0.0529801324503311 0.775724028862311 0.817266278217096 0.977670526316932 GO:0140584 chromatin extrusion motor activity 8/1273 151/18639 0.0529801324503311 0.775724028862311 0.817266278217096 0.977670526316932 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 8/1273 151/18639 0.0529801324503311 0.775724028862311 0.817266278217096 0.977670526316932 GO:0140849 ATP-dependent H2AZ histone chaperone activity 8/1273 151/18639 0.0529801324503311 0.775724028862311 0.817266278217096 0.977670526316932 GO:0046915 transition metal ion transmembrane transporter activity 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.977670526316932 GO:0051539 4 iron, 4 sulfur cluster binding 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.977670526316932 GO:0140303 intramembrane lipid transporter activity 2/1273 45/18639 0.0444444444444444 0.650746268656716 0.82218790699953 0.977670526316932 GO:0015616 DNA translocase activity 8/1273 152/18639 0.0526315789473684 0.770620581304006 0.822769766480577 0.977670526316932 GO:0140674 ATP-dependent histone chaperone activity 8/1273 152/18639 0.0526315789473684 0.770620581304006 0.822769766480577 0.977670526316932 GO:0008135 translation factor activity, RNA binding 4/1273 83/18639 0.0481927710843374 0.705628484085596 0.82710351432094 0.977670526316932 GO:0061775 cohesin loader activity 8/1273 153/18639 0.0522875816993464 0.76558384547849 0.828144176226399 0.977670526316932 GO:0008139 nuclear localization sequence binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0008483 transaminase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0019707 protein-cysteine S-acyltransferase activity 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0042974 nuclear retinoic acid receptor binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1273 25/18639 0.04 0.585671641791045 0.829620695923602 0.977670526316932 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/1273 46/18639 0.0434782608695652 0.63659961064244 0.831527692861881 0.978657206686232 GO:0005216 monoatomic ion channel activity 26/1273 448/18639 0.0580357142857143 0.849746801705757 0.832850263733901 0.978657206686232 GO:0046943 carboxylic acid transmembrane transporter activity 10/1273 188/18639 0.0531914893617021 0.778818672594474 0.834038169754153 0.978657206686232 GO:0180051 translation factor activity 4/1273 84/18639 0.0476190476190476 0.697228144989339 0.83407257781292 0.978657206686232 GO:0005342 organic acid transmembrane transporter activity 10/1273 189/18639 0.0529100529100529 0.774697938877043 0.838694812556433 0.980730330094962 GO:0004435 phosphatidylinositol phospholipase C activity 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.980730330094962 GO:0005160 transforming growth factor beta receptor binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.980730330094962 GO:0008157 protein phosphatase 1 binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.980730330094962 GO:0051139 metal cation:proton antiporter activity 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.980730330094962 GO:0097602 cullin family protein binding 1/1273 26/18639 0.0384615384615385 0.563145809414466 0.841272831632705 0.980730330094962 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/1273 48/18639 0.0416666666666667 0.610074626865672 0.848889150942407 0.988191699849784 GO:0005261 monoatomic cation channel activity 19/1273 341/18639 0.0557184750733138 0.815818269357027 0.851217710429885 0.988191699849784 GO:0140223 general transcription initiation factor activity 3/1273 68/18639 0.0441176470588235 0.645961369622476 0.85205614744047 0.988191699849784 GO:0008395 steroid hydroxylase activity 1/1273 27/18639 0.037037037037037 0.54228855721393 0.852128668162634 0.988191699849784 GO:0140658 ATP-dependent chromatin remodeler activity 8/1273 158/18639 0.0506329113924051 0.741356508596259 0.853129680237847 0.988191699849784 GO:0000149 SNARE binding 5/1273 106/18639 0.0471698113207547 0.690650520980006 0.857793381832219 0.988191699849784 GO:0005267 potassium channel activity 6/1273 124/18639 0.0483870967741935 0.708473760231103 0.858146948676507 0.988191699849784 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1273 69/18639 0.0434782608695652 0.63659961064244 0.858864790862626 0.988191699849784 GO:0020037 heme binding 7/1273 142/18639 0.0492957746478873 0.721778431784738 0.859808527094906 0.988191699849784 GO:0050698 proteoglycan sulfotransferase activity 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.988191699849784 GO:0051537 2 iron, 2 sulfur cluster binding 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.988191699849784 GO:0051959 dynein light intermediate chain binding 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.988191699849784 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.988191699849784 GO:0141052 histone H3 demethylase activity 1/1273 28/18639 0.0357142857142857 0.522921108742004 0.862242584207604 0.988191699849784 GO:0003689 DNA clamp loader activity 8/1273 160/18639 0.05 0.732089552238806 0.862272535880005 0.988191699849784 GO:0015079 potassium ion transmembrane transporter activity 8/1273 160/18639 0.05 0.732089552238806 0.862272535880005 0.988191699849784 GO:0005319 lipid transporter activity 9/1273 178/18639 0.050561797752809 0.74031527754486 0.865233857368331 0.989678033319779 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/1273 70/18639 0.0428571428571429 0.627505330490405 0.865397135322097 0.989678033319779 GO:0004843 cysteine-type deubiquitinase activity 5/1273 108/18639 0.0462962962962963 0.677860696517413 0.868467477913351 0.991427486615489 GO:0140299 molecular sensor activity 3/1273 71/18639 0.0422535211267606 0.618667227244061 0.871661696969994 0.991427486615489 GO:0016417 S-acyltransferase activity 1/1273 29/18639 0.0344827586206897 0.50488934637159 0.871665247702511 0.991427486615489 GO:0005272 sodium channel activity 2/1273 51/18639 0.0392156862745098 0.574187884108867 0.871889404133028 0.991427486615489 GO:0019783 ubiquitin-like protein peptidase activity 6/1273 127/18639 0.047244094488189 0.691738159595722 0.872833210962032 0.991427486615489 GO:0031490 chromatin DNA binding 6/1273 128/18639 0.046875 0.686333955223881 0.877437437158118 0.991427486615489 GO:0140713 histone chaperone activity 8/1273 164/18639 0.0487804878048781 0.714233709501274 0.879173745359012 0.991427486615489 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.991427486615489 GO:0031210 phosphatidylcholine binding 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.991427486615489 GO:0032452 histone demethylase activity 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.991427486615489 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1273 30/18639 0.0333333333333333 0.488059701492537 0.880443868856444 0.991427486615489 GO:0016887 ATP hydrolysis activity 23/1273 417/18639 0.0551558752997602 0.807580801030817 0.882329487152825 0.991427486615489 GO:0015103 inorganic anion transmembrane transporter activity 8/1273 165/18639 0.0484848484848485 0.709905020352782 0.883121211480798 0.991427486615489 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/1273 73/18639 0.0410958904109589 0.601717440196279 0.883421264422589 0.991427486615489 GO:0043539 protein serine/threonine kinase activator activity 3/1273 73/18639 0.0410958904109589 0.601717440196279 0.883421264422589 0.991427486615489 GO:0015631 tubulin binding 21/1273 385/18639 0.0545454545454545 0.798643147896879 0.884332011826993 0.991427486615489 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1273 53/18639 0.0377358490566038 0.552520416784005 0.885384297546422 0.991427486615489 GO:0008514 organic anion transmembrane transporter activity 14/1273 269/18639 0.0520446096654275 0.762026299728125 0.885712959982931 0.991427486615489 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/1273 130/18639 0.0461538461538462 0.675774971297359 0.886226453862902 0.991427486615489 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.991427486615489 GO:0016411 acylglycerol O-acyltransferase activity 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.991427486615489 GO:0070273 phosphatidylinositol-4-phosphate binding 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.991427486615489 GO:0140457 protein demethylase activity 1/1273 31/18639 0.032258064516129 0.472315840154068 0.888622435944721 0.991427486615489 GO:0031491 nucleosome binding 3/1273 74/18639 0.0405405405405405 0.59358612343687 0.888932970589902 0.991427486615489 GO:0008509 monoatomic anion transmembrane transporter activity 7/1273 149/18639 0.0469798657718121 0.687869377942502 0.89007092383797 0.991427486615489 GO:0017069 snRNA binding 2/1273 54/18639 0.037037037037037 0.54228855721393 0.891626542291414 0.991427486615489 GO:0016410 N-acyltransferase activity 4/1273 94/18639 0.0425531914893617 0.62305493807558 0.891643926097402 0.991427486615489 GO:0047498 calcium-dependent phospholipase A2 activity 1/1273 32/18639 0.03125 0.457555970149254 0.896241935033413 0.995517964760191 GO:0051536 iron-sulfur cluster binding 3/1273 76/18639 0.0394736842105263 0.577965435978005 0.899261211189242 0.996440898657643 GO:0101005 deubiquitinase activity 5/1273 115/18639 0.0434782608695652 0.63659961064244 0.900638684355469 0.996440898657643 GO:0046906 tetrapyrrole binding 7/1273 152/18639 0.0460526315789474 0.674293008641005 0.901250582413452 0.996440898657643 GO:0030170 pyridoxal phosphate binding 2/1273 56/18639 0.0357142857142857 0.522921108742004 0.903173674406002 0.996440898657643 GO:0170055 lipid transmembrane transporter activity 2/1273 56/18639 0.0357142857142857 0.522921108742004 0.903173674406002 0.996440898657643 GO:0051540 metal cluster binding 3/1273 77/18639 0.038961038961039 0.570459391354914 0.904093771030786 0.996440898657643 GO:0003774 cytoskeletal motor activity 7/1273 153/18639 0.0457516339869281 0.669885864793679 0.904755684079955 0.996440898657643 GO:0005525 GTP binding 20/1273 378/18639 0.0529100529100529 0.774697938877043 0.90741117891424 0.996440898657643 GO:0070279 vitamin B6 binding 2/1273 57/18639 0.0350877192982456 0.513747054202671 0.908506438182676 0.996440898657643 GO:0008170 N-methyltransferase activity 4/1273 98/18639 0.0408163265306122 0.597624124276576 0.909252469326831 0.996440898657643 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.996440898657643 GO:0016831 carboxy-lyase activity 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.996440898657643 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.996440898657643 GO:0051427 hormone receptor binding 1/1273 34/18639 0.0294117647058824 0.430640913081651 0.909953876982834 0.996440898657643 GO:0140566 histone reader activity 1/1273 35/18639 0.0285714285714286 0.418336886993603 0.916115054870544 0.999999999751768 GO:0031593 polyubiquitin modification-dependent protein binding 2/1273 59/18639 0.0338983050847458 0.496331899822919 0.918356627649953 0.999999999751768 GO:0019001 guanyl nucleotide binding 21/1273 400/18639 0.0525 0.768694029850746 0.918483935563685 0.999999999751768 GO:0032561 guanyl ribonucleotide binding 21/1273 400/18639 0.0525 0.768694029850746 0.918483935563685 0.999999999751768 GO:0015101 organic cation transmembrane transporter activity 3/1273 81/18639 0.037037037037037 0.54228855721393 0.921393787756424 0.999999999751768 GO:0004033 aldo-keto reductase (NADPH) activity 1/1273 36/18639 0.0277777777777778 0.406716417910448 0.921854978282165 0.999999999751768 GO:0004190 aspartic-type endopeptidase activity 1/1273 36/18639 0.0277777777777778 0.406716417910448 0.921854978282165 0.999999999751768 GO:0045505 dynein intermediate chain binding 1/1273 36/18639 0.0277777777777778 0.406716417910448 0.921854978282165 0.999999999751768 GO:0055106 ubiquitin-protein transferase regulator activity 1/1273 36/18639 0.0277777777777778 0.406716417910448 0.921854978282165 0.999999999751768 GO:0003697 single-stranded DNA binding 5/1273 121/18639 0.0413223140495868 0.605032687800666 0.922539579865576 0.999999999751768 GO:0019213 deacetylase activity 1/1273 37/18639 0.027027027027027 0.395724082291247 0.92720242829812 0.999999999751768 GO:0022829 wide pore channel activity 1/1273 37/18639 0.027027027027027 0.395724082291247 0.92720242829812 0.999999999751768 GO:0070001 aspartic-type peptidase activity 1/1273 37/18639 0.027027027027027 0.395724082291247 0.92720242829812 0.999999999751768 GO:0042162 telomeric DNA binding 1/1273 38/18639 0.0263157894736842 0.385310290652003 0.932184221050324 0.999999999751768 GO:0042887 amide transmembrane transporter activity 1/1273 38/18639 0.0263157894736842 0.385310290652003 0.932184221050324 0.999999999751768 GO:0016829 lyase activity 9/1273 200/18639 0.045 0.658880597014925 0.934654772765616 0.999999999751768 GO:0015293 symporter activity 6/1273 146/18639 0.0410958904109589 0.601717440196279 0.939080720448346 0.999999999751768 GO:0015144 carbohydrate transmembrane transporter activity 1/1273 40/18639 0.025 0.366044776119403 0.941149069727873 0.999999999751768 GO:0032451 demethylase activity 1/1273 40/18639 0.025 0.366044776119403 0.941149069727873 0.999999999751768 GO:0050997 quaternary ammonium group binding 1/1273 40/18639 0.025 0.366044776119403 0.941149069727873 0.999999999751768 GO:0003714 transcription corepressor activity 9/1273 204/18639 0.0441176470588235 0.645961369622476 0.943203517078926 0.999999999751768 GO:0015276 ligand-gated monoatomic ion channel activity 8/1273 186/18639 0.043010752688172 0.629754453538758 0.944193975319914 0.999999999751768 GO:0001727 lipid kinase activity 1/1273 41/18639 0.024390243902439 0.357116854750637 0.945177094580629 0.999999999751768 GO:0022834 ligand-gated channel activity 8/1273 188/18639 0.0425531914893617 0.62305493807558 0.948189586560835 0.999999999751768 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/1273 91/18639 0.032967032967033 0.482696408069542 0.952882450084397 0.999999999751768 GO:0022836 gated channel activity 15/1273 318/18639 0.0471698113207547 0.690650520980006 0.953586048617111 0.999999999751768 GO:0008094 ATP-dependent activity, acting on DNA 9/1273 210/18639 0.0428571428571429 0.627505330490405 0.954186476952157 0.999999999751768 GO:0002039 p53 binding 2/1273 69/18639 0.0289855072463768 0.424399740428293 0.954305889692182 0.999999999751768 GO:0016279 protein-lysine N-methyltransferase activity 2/1273 69/18639 0.0289855072463768 0.424399740428293 0.954305889692182 0.999999999751768 GO:0016790 thiolester hydrolase activity 1/1273 44/18639 0.0227272727272727 0.332767978290366 0.955682229960409 0.999999999751768 GO:0016278 lysine N-methyltransferase activity 2/1273 70/18639 0.0285714285714286 0.418336886993603 0.956920853056008 0.999999999751768 GO:0099094 ligand-gated monoatomic cation channel activity 5/1273 136/18639 0.0367647058823529 0.538301141352063 0.959693861171024 0.999999999751768 GO:0015294 solute:monoatomic cation symporter activity 4/1273 116/18639 0.0344827586206897 0.50488934637159 0.96079616007287 0.999999999751768 GO:0061749 forked DNA-dependent helicase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.999999999751768 GO:0140938 histone H3 methyltransferase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.999999999751768 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1273 47/18639 0.0212765957446809 0.31152746903779 0.964175651203362 0.999999999751768 GO:0046873 metal ion transmembrane transporter activity 22/1273 450/18639 0.0488888888888889 0.715820895522388 0.964870982644022 0.999999999751768 GO:0003684 damaged DNA binding 2/1273 74/18639 0.027027027027027 0.395724082291247 0.966016270092827 0.999999999751768 GO:0035064 methylated histone binding 2/1273 74/18639 0.027027027027027 0.395724082291247 0.966016270092827 0.999999999751768 GO:0009378 four-way junction helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.999999999751768 GO:0032266 phosphatidylinositol-3-phosphate binding 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.999999999751768 GO:0036121 double-stranded DNA helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.999999999751768 GO:0043138 3'-5' DNA helicase activity 1/1273 48/18639 0.0208333333333333 0.305037313432836 0.966628555464233 0.999999999751768 GO:0005249 voltage-gated potassium channel activity 3/1273 98/18639 0.0306122448979592 0.448218093207432 0.967425095164435 0.999999999751768 GO:0008017 microtubule binding 12/1273 276/18639 0.0434782608695652 0.63659961064244 0.968358665133013 0.999999999751768 GO:0140034 methylation-dependent protein binding 2/1273 76/18639 0.0263157894736842 0.385310290652003 0.969840918772699 0.999999999751768 GO:0022843 voltage-gated monoatomic cation channel activity 5/1273 143/18639 0.034965034965035 0.511950735831333 0.970681486008678 0.999999999751768 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/1273 122/18639 0.0327868852459016 0.480058722779545 0.970748724092092 0.999999999751768 GO:0015605 organophosphate ester transmembrane transporter activity 1/1273 50/18639 0.02 0.292835820895522 0.971042353791131 0.999999999751768 GO:0016830 carbon-carbon lyase activity 1/1273 51/18639 0.0196078431372549 0.287093942054434 0.973025412784294 0.999999999751768 GO:0015370 solute:sodium symporter activity 2/1273 79/18639 0.0253164556962025 0.37067825429813 0.974810276904803 0.999999999751768 GO:0016835 carbon-oxygen lyase activity 2/1273 79/18639 0.0253164556962025 0.37067825429813 0.974810276904803 0.999999999751768 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1273 52/18639 0.0192307692307692 0.281572904707233 0.974872768579731 0.999999999751768 GO:0140296 general transcription initiation factor binding 1/1273 53/18639 0.0188679245283019 0.276260208392002 0.976593700714987 0.999999999751768 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/1273 229/18639 0.0393013100436681 0.57544156944535 0.977573374780325 0.999999999751768 GO:0008374 O-acyltransferase activity 1/1273 55/18639 0.0181818181818182 0.266214382632293 0.979690285050183 0.999999999751768 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/1273 57/18639 0.0175438596491228 0.256873527101335 0.982377479330842 0.999999999751768 GO:0004386 helicase activity 5/1273 155/18639 0.032258064516129 0.472315840154068 0.983304159633727 0.999999999751768 GO:0017116 single-stranded DNA helicase activity 1/1273 58/18639 0.0172413793103448 0.252444673185795 0.983584748129241 0.999999999751768 GO:0070063 RNA polymerase binding 1/1273 59/18639 0.0169491525423729 0.24816594991146 0.984709370896125 0.999999999751768 GO:0015297 antiporter activity 4/1273 135/18639 0.0296296296296296 0.433830845771144 0.984781708781962 0.999999999751768 GO:0140097 catalytic activity, acting on DNA 14/1273 336/18639 0.0416666666666667 0.610074626865672 0.98561900667023 0.999999999751768 GO:0001098 basal transcription machinery binding 1/1273 60/18639 0.0166666666666667 0.244029850746269 0.98575700118941 0.999999999751768 GO:0001099 basal RNA polymerase II transcription machinery binding 1/1273 60/18639 0.0166666666666667 0.244029850746269 0.98575700118941 0.999999999751768 GO:0016836 hydro-lyase activity 1/1273 61/18639 0.0163934426229508 0.240029361389772 0.986732906108183 0.999999999751768 GO:0140767 enzyme-substrate adaptor activity 4/1273 139/18639 0.0287769784172662 0.421346504885644 0.987612008197857 0.999999999751768 GO:1901682 sulfur compound transmembrane transporter activity 1/1273 63/18639 0.0158730158730159 0.232409381663113 0.988488832508723 0.999999999751768 GO:0015081 sodium ion transmembrane transporter activity 5/1273 164/18639 0.0304878048780488 0.446396068438296 0.989197059944431 0.999999999751768 GO:0160215 deacylase activity 1/1273 65/18639 0.0153846153846154 0.225258323765786 0.990012516755525 0.999999999751768 GO:0008276 protein methyltransferase activity 2/1273 95/18639 0.0210526315789474 0.308248232521602 0.99051871472377 0.999999999751768 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/1273 167/18639 0.029940119760479 0.438376977388507 0.990677585999426 0.999999999751768 GO:0016407 acetyltransferase activity 2/1273 96/18639 0.0208333333333333 0.305037313432836 0.991087794137705 0.999999999751768 GO:0042054 histone methyltransferase activity 1/1273 67/18639 0.0149253731343284 0.218534194698151 0.991334654705695 0.999999999751768 GO:0003777 microtubule motor activity 1/1273 68/18639 0.0147058823529412 0.215320456540825 0.991928612521744 0.999999999751768 GO:0005548 phospholipid transporter activity 1/1273 68/18639 0.0147058823529412 0.215320456540825 0.991928612521744 0.999999999751768 GO:0030527 structural constituent of chromatin 2/1273 98/18639 0.0204081632653061 0.298812062138288 0.992127578957739 0.999999999751768 GO:0008080 N-acetyltransferase activity 1/1273 69/18639 0.0144927536231884 0.212199870214147 0.992481887857472 0.999999999751768 GO:0003713 transcription coactivator activity 9/1273 256/18639 0.03515625 0.51475046641791 0.992486557232861 0.999999999751768 GO:0005244 voltage-gated monoatomic ion channel activity 5/1273 173/18639 0.0289017341040462 0.423173151583125 0.993080067010034 0.999999999751768 GO:0140030 modification-dependent protein binding 5/1273 173/18639 0.0289017341040462 0.423173151583125 0.993080067010034 0.999999999751768 GO:0022832 voltage-gated channel activity 5/1273 175/18639 0.0285714285714286 0.418336886993603 0.993740208621614 0.999999999751768 GO:0003678 DNA helicase activity 1/1273 74/18639 0.0135135135135135 0.197862041145623 0.994729085238937 0.999999999751768 GO:0015291 secondary active transmembrane transporter activity 10/1273 287/18639 0.0348432055749129 0.510166935358053 0.995199458149547 0.999999999751768 GO:0008168 methyltransferase activity 6/1273 204/18639 0.0294117647058824 0.430640913081651 0.995498992982445 0.999999999751768 GO:0003712 transcription coregulator activity 20/1273 495/18639 0.0404040404040404 0.591587516960651 0.997111080531826 0.999999999751768 GO:0016755 aminoacyltransferase activity 20/1273 496/18639 0.0403225806451613 0.590394800192585 0.997209267931003 0.999999999751768 GO:0016741 transferase activity, transferring one-carbon groups 6/1273 215/18639 0.027906976744186 0.408608122179799 0.99737744117574 0.999999999751768 GO:0004842 ubiquitin-protein transferase activity 17/1273 449/18639 0.0378619153674833 0.554366253365688 0.998077508208391 0.999999999751768 GO:0061630 ubiquitin protein ligase activity 12/1273 353/18639 0.0339943342776204 0.497737939199188 0.998324391890709 0.999999999751768 GO:0042393 histone binding 7/1273 247/18639 0.0283400809716599 0.41494954377908 0.998356284554069 0.999999999751768 GO:0019787 ubiquitin-like protein transferase activity 18/1273 479/18639 0.0375782881002088 0.550213442183654 0.998703510238192 0.999999999751768 GO:0061659 ubiquitin-like protein ligase activity 12/1273 372/18639 0.032258064516129 0.472315840154068 0.999252948120345 0.999999999751768 GO:0003730 mRNA 3'-UTR binding 6/1273 262/18639 0.0229007633587786 0.335308191865102 0.99976859190151 0.999999999751768 GO:0045182 translation regulator activity 2/1273 356/18639 0.00561797752808989 0.08225725306054 0.999999999751768 0.999999999751768