category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/222	238/9376	3.72655007949126	RPS25/RPS17/RPS18/RPL7A/RPL37/RPS27/RPS9/RPS21/RPL37A/RPL34/RPS29/C7/CFD/RPL17/RPL36/RPL41/RPS28/RPL38/RPL39/EIF2AK2/C1R	6.63487968623537
Genetic Information Processing	Translation	hsa03010	Ribosome	20/222	222/9376	3.80488596704813	RPS25/RPS17/RPS18/RPL7A/RPL37/RPS27/RPS9/RPS21/RPL37A/RPL34/RPS29/MRPS24/RPL17/RPL36/RPL41/RPS28/MRPL23/RPL38/RPL39/MRPS18B	6.58632131779058
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/222	157/9376	3.76611005910369	HLA-B/HRAS/SQSTM1/GADD45A/CCND2/CDKN1A/PPP3R1/PPP1CB/HLA-C/HLA-A/CAPN2/CDK6/CCNB1/SMAD2	5.44294625613387
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/222	275/9376	2.7644226044226	HSPA1A/HSPA1B/PSMB3/C7/PSMA2/NDUFA6/NDUFA3/TUBB/PSMA6/CSNK2B/PSMC4/CAV2/TUBA4A/PPP3R1/MT-CO1/COX7C/GSK3B/MT-ND3	4.62467346751358
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/222	158/9376	3.4749686395256	CDKN1C/YWHAE/SFN/CDK7/SKP1/GADD45A/CCND2/CDKN1A/WEE1/CDK6/GSK3B/CCNB1/SMAD2	4.8858098788266
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/222	233/9376	2.900204925956	DCN/THBS1/VIM/VCAN/COL3A1/SDC4/COL6A1/COL5A1/DSP/ITGB6/TMOD3/FMNL2/SGCE/PDLIM4/MYH10/COL6A2	4.57394261482514
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/222	82/9376	4.63546473302571	CTSL/HSPA1A/HSPA1B/B2M/PSME1/HLA-B/PSME2/HLA-C/HLA-A	5.14899179164263
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	16/222	250/9376	2.70299099099099	HSPA1A/HSPA1B/CDC42/HLA-B/HRAS/VPS28/CAV2/FOLR1/STAMBP/WASL/HLA-C/WASHC3/HLA-A/SMAD2/CLTB/PRKCI	4.25009652958123
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/222	203/9376	2.91270580925753	THBS1/EMP1/CDC42/HRAS/LAMB3/COL6A1/CAV2/ITGB6/CCND2/PPP1CB/CAPN2/PDGFD/GSK3B/COL6A2	4.29039393955918
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/222	75/9376	4.50498498498499	THBS1/SFN/GADD45A/CCND2/CDKN1A/PPP1R13L/CDK6/CCNB1	4.7457913750525
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/222	46/9376	5.50881316098707	PSMB3/PSMA2/PSME1/PSMA6/PSME2/PSMC4	4.77372068539108
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/222	174/9376	2.91270580925753	HSPA1A/HSPA1B/CRYAB/RNF5/XBP1/SKP1/STT3A/CAPN2/TRAM1/RPN1/OS9/SAR1A	3.96586893979814
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	20/222	388/9376	2.17702238320795	DKK1/PSMB3/PSMA2/NDUFA6/NDUFA3/TUBB/PSMA6/CSNK1A1/CSNK2B/HRAS/PSMC4/XBP1/TUBA4A/PPP3R1/EIF2AK2/MT-CO1/CAPN2/COX7C/GSK3B/MT-ND3	3.68744646713716
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/222	333/9376	2.28293158022888	THBS1/CDC42/ATP6V0C/HLA-B/CSNK1A1/HRAS/LAMB3/COL6A1/ITGB6/CCND2/CDKN1A/EIF2AK2/HLA-C/HLA-A/CDK6/GSK3B/PRKCI/COL6A2	3.71215428765113
NA	NA	hsa04518	Integrin signaling	11/222	154/9376	3.01673101673102	THBS1/CDC42/LAMB3/COL6A1/ITGB6/CCND2/FERMT2/VCAM1/PDGFD/GSK3B/COL6A2	3.9296371468018
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/222	204/9376	2.69139727963257	DCN/LUM/IGF2/CTSL/THBS1/CDC42/HRAS/SDC4/CAV2/GPC3/CDKN1A/PPP1CB/SMAD2	3.80351698357381
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/222	155/9376	2.99726823597791	CTSL/THBS1/ATP6V0C/HLA-B/TUBB/DYNC1LI2/LAMP2/TUBA4A/C1R/HLA-C/HLA-A	3.90454025443075
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/222	227/9376	2.41870063896496	B2M/CCL4L2/GNG10/CCL3L1/HLA-B/HRAS/CCL4/CDKN1A/PPP3R1/HLA-C/HLA-A/CDK6/GSK3B	3.3695627658407
NA	NA	hsa04382	Cornified envelope formation	12/222	217/9376	2.3355336903724	KRT6A/KRT5/KRT14/SPRR3/KRT17/KRT23/S100A8/KRT24/LAMB3/DSP/S100A4/S100A14	3.09968353827543
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/222	70/9376	3.62007722007722	HLA-B/EIF4G1/EIF4G2/HLA-C/HLA-A/SGCE	3.42640155525223
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/222	169/9376	2.49906711445173	CTSL/GABARAP/HRAS/SQSTM1/LAMP2/CALCOCO2/ATG9B/VMP1/WDR45B/GABARAPL1	3.06240079691106
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/222	205/9376	2.26622720281257	B2M/VIM/HLA-B/PSMC4/GADD45A/CCND2/CDKN1A/EIF2AK2/HLA-C/HLA-A/CDK6	2.85454500535254
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/222	205/9376	2.26622720281257	YWHAE/CDC42/HLA-B/HRAS/CCND2/MRPS18B/CDKN1A/EIF2AK2/HLA-C/HLA-A/CDK6	2.85454500535254
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/222	480/9376	1.75975975975976	DKK1/PSMB3/PSMA2/NDUFA6/NDUFA3/TUBB/PSMA6/CSNK1A1/CSNK2B/HRAS/SQSTM1/PSMC4/XBP1/TUBA4A/PPP3R1/MT-CO1/CAPN2/COX7C/GSK3B/MT-ND3	2.66106933646738
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/222	101/9376	2.92712514494693	CDC42/COL3A1/HRAS/VCAM1/PIM1/F3/SMAD2	3.03228709203411
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/222	56/9376	3.77091377091377	EEF1G/HSPA1A/HSPA1B/RAB1B/SAR1A	3.23866285087608
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/222	268/9376	2.04867554121285	PSMB3/PSMA2/NDUFA6/NDUFA3/DUSP1/TUBB/PSMA6/PSMC4/XBP1/TUBA4A/MT-CO1/COX7C/MT-ND3	2.7123997537464
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/222	105/9376	2.81561561561562	GABARAP/CSNK2B/HRAS/SQSTM1/CALCOCO2/ATG9B/GABARAPL1	2.91347931943228
NA	NA	hsa04519	Cadherin signaling	17/222	404/9376	1.77718312371778	KRT6A/KRT5/KRT14/VIM/YWHAE/CDC42/KRT17/KRT23/KRT24/CSNK1A1/HRAS/DSP/PPP1CB/GABRA4/AFDN/LIMA1/GSK3B	2.48671539446984
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/222	196/9376	2.15480786909358	GNG10/HLA-B/HRAS/CDKN1A/PPP3R1/EIF2AK2/HLA-C/HLA-A/CDK6/GSK3B	2.54432802188997
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/222	89/9376	2.84725174612815	THBS1/SDC4/LAMB3/COL6A1/ITGB6/COL6A2	2.72671682341015
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/222	170/9376	2.23593004769475	IGF2/CSNK1A1/HRAS/GADD45A/CDKN1A/TXNRD2/CDK6/GSK3B/SMAD2	2.53244217523212
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/222	73/9376	2.8927557694681	HRAS/GADD45A/CDKN1A/PDGFD/CDK6	2.5281402885381
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/222	99/9376	2.55965055965056	KRT14/KRT17/CFD/KRT23/KRT24/C1R	2.42939311181272
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/222	50/9376	3.37873873873874	THBS1/HBB/HBA2/VCAM1	2.62627810656614
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	10/222	214/9376	1.97356234739412	B2M/GNG10/HLA-B/HRAS/SKP1/WEE1/PPP3R1/HLA-C/HLA-A/CCNB1	2.24353156168366
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/222	308/9376	1.78261378261378	PSMB3/PSMA2/NDUFA6/NDUFA3/TUBB/PSMA6/PSMC4/POLR2L/TUBA4A/MT-CO1/COX7C/MT-ND3/CLTB	2.17482224197709
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/222	77/9376	2.74248274248274	CDC42/GADD45A/CDKN1A/CDK6/SMAD2	2.3908503631826
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/222	77/9376	2.74248274248274	HRAS/GADD45A/CDKN1A/CTBP1/CDK6	2.3908503631826
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/222	105/9376	2.41338481338481	CCL4L2/CSNK2B/CCL4/GADD45A/VCAM1/PPP1R13L	2.26802820419678
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/222	133/9376	2.22285443338075	GABARAP/HRAS/GADD45A/CCND2/CDKN1A/GABARAPL1/CCNB1	2.21182507746551
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/222	54/9376	3.12846179512846	CGA/HLA-B/HLA-C/HLA-A	2.44267035213076
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/222	32/9376	3.95945945945946	GABARAP/ATG9B/GABARAPL1	2.6114255010593
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	10/222	224/9376	1.88545688545689	B2M/HLA-B/HRAS/CCND2/CDKN1A/PPP3R1/HLA-C/MSX1/HLA-A/SMAD2	2.08876746516578
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/222	136/9376	2.17382087970323	HSPA1A/HSPA1B/CSNK2B/CCND2/EIF2AK2/CDK6/GSK3B	2.14729627318918
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/222	110/9376	2.3036855036855	DCN/THBS1/ID4/SKP1/TGIF1/SMAD2	2.14180388722696
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/222	139/9376	2.12690388229957	HSPA1A/HSPA1B/KRT14/KRT17/KRT23/KRT24/HRAS	2.08442116729273
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/222	362/9376	1.63336817480464	IGF2/THBS1/YWHAE/GNG10/HRAS/LAMB3/COL6A1/ITGB6/CCND2/CDKN1A/PDGFD/CDK6/GSK3B/COL6A2	1.91385229436893
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/222	59/9376	2.86333791418537	HRAS/GADD45A/CDKN1A/GSK3B	2.23581698104597
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	14/222	368/9376	1.60673717195456	PSMB3/PSMA2/NDUFA6/NDUFA3/TUBB/PSMA6/SQSTM1/PSMC4/XBP1/TUBA4A/PPP3R1/MT-CO1/COX7C/MT-ND3	1.84912808543129
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/222	205/9376	1.85418589321028	NDUFA6/NDUFA3/COL3A1/PPP1CB/MT-CO1/COX7C/GSK3B/MT-ND3/SMAD2	1.92565131256854
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/222	87/9376	2.42725484104794	HRAS/GADD45A/CDKN1A/GSK3B/SMAD2	2.08273176609681
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/222	37/9376	3.42439737034332	HBB/HBA2/VCAM1	2.30097102574698
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/222	37/9376	3.42439737034332	HRAS/GADD45A/CDKN1A	2.30097102574698
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/222	88/9376	2.3996723996724	C7/CFD/SERPINB2/C1R/F3	2.05429733554884
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/222	62/9376	2.72478930543447	HSPA1A/HSPA1B/CRYAB/HRAS	2.12187819550669
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/222	17/9376	4.96873343932167	LAMP2/MYH10	2.55045895563903
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/222	178/9376	1.8981678307521	DKK1/CSNK1A1/CSNK2B/SKP1/CCND2/CTBP1/PPP3R1/GSK3B	1.8839851098299
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/222	39/9376	3.24878724878725	HLA-B/HLA-C/HLA-A	2.19146059293084
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/222	93/9376	2.27065775452872	CDC42/CSNK2B/PDCD10/WASL/AFDN	1.91770836057184
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/222	216/9376	1.75975975975976	HSPA1A/HSPA1B/CDC42/CCL3L1/HRAS/XBP1/VCAM1/PPP3R1/GSK3B	1.7591873676617
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/222	41/9376	3.09030982201714	THBS1/HRAS/CDKN1A	2.08882520758147
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/222	157/9376	1.88305502955184	CDC42/NDUFA6/NDUFA3/XBP1/MT-CO1/COX7C/GSK3B	1.73761020507508
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/222	70/9376	2.41338481338481	CDC42/HRAS/EPAS1/CDKN1A	1.84835160034286
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/222	44/9376	2.87960687960688	HLA-B/HLA-C/HLA-A	1.94608887732314
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/222	71/9376	2.37939347798503	CGA/HRAS/CCND2/GSK3B	1.81683641225675
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/222	21/9376	4.02230802230802	ENPP1/BCAT1	2.15915165137138
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/222	193/9376	1.75064183354339	CCL4L2/CDC42/CXCL14/GNG10/CCL3L1/HRAS/CCL4/GSK3B	1.64087613202316
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/222	45/9376	2.81561561561562	HLA-B/HLA-C/HLA-A	1.90117783712592
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/222	73/9376	2.31420461557448	HRAS/GADD45A/CDKN1A/CDK6	1.75537366712148
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/222	232/9376	1.63839701770736	TMSB4X/C7/CDC42/HRAS/ITGB6/WASL/PPP1CB/PDGFD/MYH10	1.53328682750051
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/222	300/9376	1.54858858858859	IGF2/HSPA1A/HSPA1B/CDC42/DUSP1/HRAS/GADD45A/PPP3R1/JUND/PDGFD/RASA1	1.50389260760946
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/222	76/9376	2.22285443338075	HRAS/GADD45A/CDKN1A/CDK6	1.66685090677878
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/222	137/9376	1.84967449201026	CTSL/HRAS/CTSW/GADD45A/TUBA4A/CAPN2	1.56011657870609
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/222	106/9376	1.99218086010539	HRAS/FOLR1/CDKN1A/PDGFD/GSK3B	1.59978117435466
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/222	138/9376	1.83627105366236	ATP6V0C/NDUFA6/NDUFA3/MT-CO1/COX7C/MT-ND3	1.5411833204276
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/222	138/9376	1.83627105366236	HRAS/PPP1CB/FLOT1/GSK3B/PHKB/PRKCI	1.5411833204276
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/222	78/9376	2.16585816585817	CDC42/CAV2/WASL/CLTB	1.61010767697141
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/222	142/9376	1.78454510848877	CTSL/DUSP1/SQSTM1/SDC4/CAV2/VCAM1	1.46697876541654
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/222	83/9376	2.03538478237273	CCL4L2/CCL4/POLR2L/GSDME	1.47543311489322
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/222	180/9376	1.64244244244244	B2M/HLA-B/SRSF5/EIF2AK2/PPP1CB/HLA-C/HLA-A	1.35527574880349
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/222	148/9376	1.71219868517166	CSNK1A1/HRAS/GADD45A/CDKN1A/CDK6/GSK3B	1.35998745942346
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/222	85/9376	1.98749337572867	NME2/ENPP1/ADSL/AK6	1.42419381436396
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/222	150/9376	1.68936936936937	CSNK1A1/HRAS/GADD45A/CDKN1A/GSK3B/SMAD2	1.32540180695302
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/222	253/9376	1.50240358936011	UBE2V1/CDC42/SQSTM1/SKP1/CALCOCO2/WASL/CAPN2/CAST/GSK3B	1.26153942679787
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/222	56/9376	2.26254826254826	STT3A/RPN1/DPM2	1.47567499150461
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/222	56/9376	2.26254826254826	CSNK1A1/CCND2/GSK3B	1.47567499150461
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/222	89/9376	1.8981678307521	TUBB/HRAS/TUBA4A/PDGFD	1.32577995364777
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/222	89/9376	1.8981678307521	GNG10/GABARAP/GABRA4/GABARAPL1	1.32577995364777
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/222	156/9376	1.62439362439362	YWHAE/HRAS/CDKN1A/EIF2AK2/CDK6/GSK3B	1.22464995229461
NA	NA	hsa04981	Folate transport and metabolism	2/222	31/9376	2.72478930543447	MTHFS/FOLR1	1.49790377785857
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/222	157/9376	1.6140471681873	YWHAE/CCND2/PPP1CB/GSK3B/SMAD2/PRKCI	1.20827648349525
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/222	91/9376	1.85644985644986	HRAS/IFITM1/PPP3R1/GSK3B	1.27846356162737
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/222	60/9376	2.11171171171171	CDC42/HRAS/PPP3R1	1.34527086785359
NA	NA	hsa04517	IgSF CAM signaling	10/222	299/9376	1.41251619512489	CDC42/TUBB/SLIT2/TUBA4A/WASL/AFDN/RASA1/GSK3B/PRKCI/MYH10	1.12891722920691
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/222	61/9376	2.07709348692955	FTH1/SLC40A1/ATP2B1	1.3142668660081
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/222	93/9376	1.81652620362298	LAMB3/GADD45A/CDKN1A/CDK6	1.23232170246703
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/222	160/9376	1.58378378378378	VCAN/HLA-B/SDC4/VCAM1/HLA-C/HLA-A	1.15983832910461
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/222	94/9376	1.79720145677592	S100A8/USP25/JUND/GSK3B	1.2096727563143
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/222	63/9376	2.01115401115401	CDK7/POLE3/POLR2L	1.25400553563625
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/222	63/9376	2.01115401115401	GADD45A/CDKN1A/GSK3B	1.25400553563625
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/222	34/9376	2.48436671966084	SKP1/RORB	1.35026001474201
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/222	133/9376	1.58775316670054	HLA-B/HRAS/PPP3R1/HLA-C/HLA-A	1.06309235014503
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/222	67/9376	1.89108511496571	HRAS/PPP3R1/PPP1CB	1.13988685818031
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/222	100/9376	1.68936936936937	CCL4L2/CXCL14/CCL3L1/CCL4	1.07926547370806
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/222	103/9376	1.64016443628094	COL3A1/COL6A1/COL5A1/COL6A2	1.0173179267185
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/222	138/9376	1.53022587805197	YWHAE/SKP1/PPP3R1/PPP1CB/CCNB1	0.97716556818993
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/222	248/9376	1.36239465271723	CDC42/AHNAK2/TUBB/HRAS/DYNC1LI2/SKP1/TUBA4A/WASL	0.900692355913296
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/222	250/9376	1.3514954954955	CTSL/ATP6V0C/CTSW/CLN3/LAMP2/AP3S1/NEU1/CLTB	0.877215319089578
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/222	144/9376	1.46646646646647	PSMB3/PSMA2/PSMA6/PSMC4/XBP1	0.87843665188753
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/222	42/9376	2.01115401115401	FTH1/SLC40A1	1.02273878837778
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/222	184/9376	1.37720329024677	CDC42/HRAS/SLIT2/PPP3R1/RASA1/GSK3B	0.804703791091888
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/222	149/9376	1.41725618235685	GNG10/NDUFA6/NDUFA3/GABRA4/MT-ND3	0.799507101192967
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/222	44/9376	1.91973791973792	STT3A/RPN1	0.952269197923262
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/222	44/9376	1.91973791973792	CDK7/TAF13	0.952269197923262
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/222	80/9376	1.58378378378378	HRAS/PDGFD/GSK3B	0.816592965578467
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/222	154/9376	1.37124137124137	NME2/DHRS3/BCAT1/ADSL/AK6	0.723370578801538
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/222	120/9376	1.40780780780781	YWHAE/CDC42/HRAS/GSK3B	0.700150104341557
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/222	16/9376	2.63963963963964	MIF	1.02217945454372
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/222	235/9376	1.25804101974315	NDUFA6/NDUFA3/HRAS/MT-CO1/COX7C/MT-ND3/PNPLA2	0.623853329916281
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/222	122/9376	1.38472899128637	CDC42/HRAS/PPP3R1/GSK3B	0.666080551260759
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/222	86/9376	1.4732872407291	HRAS/CDKN1A/GSK3B	0.686630098039901
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/222	86/9376	1.4732872407291	DSP/ITGB6/SGCE	0.686630098039901
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/222	238/9376	1.24218335983042	IGF2/CDC42/GNG10/HRAS/AFDN/PDGFD/RASA1	0.589337223830819
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/222	17/9376	2.48436671966084	TXNRD2	0.953910473326867
Organismal Systems	Immune system	hsa04611	Platelet activation	4/222	126/9376	1.34076934076934	COL3A1/PPP1CB/SNAP23/PRKCI	0.599696607011169
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/222	18/9376	2.34634634634635	NEU1	0.890344744729846
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/222	53/9376	1.59374468808431	ATP2B1/CLTB	0.675019783479046
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/222	90/9376	1.40780780780781	CSNK2B/HRAS/PPP3R1	0.605367529734783
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/222	128/9376	1.31981981981982	NME2/ENPP1/ADSL/AK6	0.567339628463946
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/222	168/9376	1.25697125697126	FTH1/SQSTM1/EIF2AK2/CAPN2/DNM1L	0.523375279467641
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/222	54/9376	1.56423089756423	ADI1/BCAT1	0.647523995211337
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/222	130/9376	1.2995148995149	GNG10/COL3A1/HRAS/SMAD2	0.53551277348504
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/222	55/9376	1.53579033579034	NEU1/CERS2	0.62058551989267
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/222	170/9376	1.24218335983042	CDC42/TUBA4A/AFDN/PRKCI/MYH10	0.496237918738134
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/222	93/9376	1.36239465271723	CDC42/CGA/HRAS	0.54693504436222
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/222	20/9376	2.11171171171171	FDFT1	0.775030410404176
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/222	212/9376	1.19530851606323	THBS1/CDC42/HRAS/AFDN/PDGFD/PRKCI	0.447922874860014
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/222	95/9376	1.33371266002845	CTSL/ATP6V0C/CCL3L1	0.509089067059363
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/222	21/9376	2.01115401115401	DSEL	0.72237337718699
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/222	59/9376	1.43166895709269	NME2/ENPP1	0.517959076081041
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/222	59/9376	1.43166895709269	CGA/PNPLA2	0.517959076081041
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/222	22/9376	1.91973791973792	AOC1	0.672563696445469
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/222	140/9376	1.20669240669241	APELA/GNG10/HRAS/SMAD2	0.383710116265045
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/222	63/9376	1.34076934076934	PTGDS/LTC4S	0.422612811684513
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/222	103/9376	1.23012332721071	DDX39B/PPP1CB/WDR33	0.365700705724329
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/222	144/9376	1.17317317317317	ID4/HRAS/GSK3B/SMAD2	0.326114894370263
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/222	227/9376	1.11632337182998	NDUFA6/NDUFA3/HRAS/MT-CO1/COX7C/MT-ND3	0.276280204399785
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/222	65/9376	1.2995148995149	CGA/HRAS	0.377340671382713
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/222	108/9376	1.17317317317317	DDX39B/IPO9/RANGAP1	0.281874735350237
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/222	27/9376	1.56423089756423	HACD3	0.45720696551726
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/222	109/9376	1.16241011653856	CCL4L2/CCL3L1/CCL4	0.265591038332199
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/222	68/9376	1.24218335983042	HRAS/PIM1	0.312124054897377
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/222	110/9376	1.15184275184275	TIMP1/EPAS1/CDKN1A	0.249460007973287
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/222	69/9376	1.22418070244157	PPP3R1/PPP1CB	0.291054679017571
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/222	28/9376	1.50836550836551	HACD3	0.419519750783025
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/222	28/9376	1.50836550836551	ATP6V0C	0.419519750783025
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/222	154/9376	1.0969930969931	HRAS/CDKN1A/PPP3R1/PPP1CB	0.188992817468161
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/222	112/9376	1.13127413127413	HSPA1A/HSPA1B/LAMB3	0.217643430418842
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/222	71/9376	1.18969673899251	CDC42/ATP6V0C	0.249854699321483
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/222	30/9376	1.40780780780781	DPM2	0.348385400289473
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/222	30/9376	1.40780780780781	FOLR1	0.348385400289473
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/222	200/9376	1.05585585585586	CDC42/TUBB/TUBA4A/WASL/MYH10	0.124340805787698
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/222	115/9376	1.10176263219741	GNG10/DUSP1/HRAS	0.170987743641413
Genetic Information Processing	Transcription	hsa03040	Spliceosome	6/222	243/9376	1.04282059837615	HSPA1A/HSPA1B/LSM2/SRSF5/DDX39B/RP9	0.105318777950707
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/222	116/9376	1.09226467847158	CDC42/VCAM1/AFDN	0.155709691868031
Human Diseases	Immune disease	hsa05310	Asthma	1/222	32/9376	1.31981981981982	PRG2	0.282208844102299
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/222	33/9376	1.27982527982528	BCAT1	0.250759510631173
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/222	33/9376	1.27982527982528	SNAP23	0.250759510631173
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/222	34/9376	1.24218335983042	POLR2L	0.220303044176044
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/222	79/9376	1.06922111985403	ATP6V0C/CLTB	0.0962138121700394
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/222	168/9376	1.00557700557701	HRAS/CCND2/CDKN1A/PIM1	0.0113587289366934
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/222	125/9376	1.01362162162162	HRAS/NSMAF/CERS2	0.023875152253139
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/222	36/9376	1.17317317317317	ENPP1	0.162111975653603
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/222	36/9376	1.17317317317317	POLE3	0.162111975653603
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/222	37/9376	1.14146579011444	ADSL	0.134263750724013
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/222	37/9376	1.14146579011444	MIF	0.134263750724013
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/222	83/9376	1.01769239118637	CSNK2B/SKP1	0.0252118249006809
NA	NA	hsa04081	Hormone signaling	5/222	219/9376	0.964251923156033	IGF2/CGA/GNG10/RAMP1/SLC40A1	-0.0833594430917622
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/222	38/9376	1.11142721669037	ENPP1	0.107179769180318
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/222	38/9376	1.11142721669037	SFN	0.107179769180318
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/222	39/9376	1.08292908292908	MTHFS	0.0808150336787027
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/222	133/9376	0.952651900020321	GNG10/PPP1CB/GSK3B	-0.0856403771754496
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/222	87/9376	0.970901936419178	MT-CO1/COX7C	-0.0424615559945731
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/222	134/9376	0.945542557482856	RAMP1/PPP1CB/MYH10	-0.0988742791353138
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/222	41/9376	1.03010327400571	MUS81	0.0300818935602503
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/222	41/9376	1.03010327400571	GABRA4	0.0300818935602503
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/222	90/9376	0.938538538538539	HRAS/EHMT1	-0.0912360489094642
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/222	183/9376	0.923152660857579	CSNK2B/FBL/REXO1/AK6	-0.163486697403581
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/222	42/9376	1.00557700557701	AOC1	0.00564090125112903
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/222	138/9376	0.918135526831179	CDC42/WASL/GSK3B	-0.150869936285419
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/222	91/9376	0.928224928224928	GNG10/GABRA4	-0.107142074000675
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/222	323/9376	0.915293001980309	THBS1/VIM/HRAS/CCND2/CDKN1A/PIM1/CDK6	-0.241257577756432
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/222	187/9376	0.903406079876668	YWHAE/GABARAP/DNM1L/GABARAPL1	-0.207774928014763
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/222	44/9376	0.95986895986896	POLE3	-0.0415504814766161
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/222	44/9376	0.95986895986896	DYNC1LI2	-0.0415504814766161
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/222	142/9376	0.892272554244385	UBE2S/SKP1/RHOBTB1	-0.201433765459913
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/222	142/9376	0.892272554244385	SQSTM1/PPP3R1/JUND	-0.201433765459913
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/222	46/9376	0.918135526831179	FTH1	-0.086674278798257
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/222	194/9376	0.87080895328318	TUBB/DYNC1LI2/TUBA4A/MYH10	-0.283153092412934
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/222	48/9376	0.87987987987988	BCAT1	-0.129926811053904
NA	NA	hsa03272	Virion - Hepatitis viruses	1/222	48/9376	0.87987987987988	LAMP2	-0.129926811053904
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/222	99/9376	0.853216853216853	HRAS/CDKN1A	-0.228637090224279
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/222	99/9376	0.853216853216853	HRAS/PDGFD	-0.228637090224279
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/222	99/9376	0.853216853216853	ITGB6/SGCE	-0.228637090224279
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/222	101/9376	0.836321469984836	HRAS/GSK3B	-0.257544402401416
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/222	50/9376	0.844684684684685	AOC1	-0.171477937271627
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/222	103/9376	0.82008221814047	CCL3L1/SMAD2	-0.285916515269838
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/222	103/9376	0.82008221814047	COL3A1/LAMB3	-0.285916515269838
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/222	51/9376	0.828122239886946	ATP6V0C	-0.191662445227423
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/222	104/9376	0.812196812196812	CRLS1/CDIPT	-0.299909062557876
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/222	52/9376	0.812196812196812	CGA	-0.211475553612548
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/222	105/9376	0.804461604461605	HRAS/PPP3R1	-0.313776256745247
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/222	105/9376	0.804461604461605	ITGB6/SGCE	-0.313776256745247
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/222	155/9376	0.81743679163034	CDKN1A/CDK6/GSK3B	-0.356900181566423
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/222	107/9376	0.789424938957649	PPP3R1/PHKB	-0.341145034552094
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/222	54/9376	0.782115448782115	MUS81	-0.250049183248376
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/222	109/9376	0.774940077692371	PPP3R1/SMAD2	-0.368042950319886
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/222	109/9376	0.774940077692371	PPP1CB/GSK3B	-0.368042950319886
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/222	57/9376	0.740951477793583	HACD3	-0.305485472824642
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/222	166/9376	0.763269293389775	PPP3R1/PPP1CB/ATP2B1	-0.479220617820277
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/222	115/9376	0.734508421464943	GNG10/HRAS	-0.446095044804273
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/222	115/9376	0.734508421464943	CDKN1A/JUND	-0.446095044804273
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/222	60/9376	0.703903903903904	HRAS	-0.358302829741663
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/222	116/9376	0.728176452314383	GNG10/PPP3R1	-0.458740674695377
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/222	117/9376	0.721952721952722	POLE3/YEATS4	-0.471287811464559
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/222	62/9376	0.681197326358617	CTBP1	-0.392198884662315
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/222	119/9376	0.709819062760239	VCAM1/DNM1L	-0.496093914082278
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/222	63/9376	0.67038467038467	EHMT1	-0.408779912267227
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/222	173/9376	0.732385564755507	CALCOCO2/EIF2AK2/CDK6	-0.553253981096874
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/222	226/9376	0.74750857051742	CGA/PPP1CB/AFDN/ATP2B1	-0.598338550518699
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/222	122/9376	0.692364495643184	HRAS/GSK3B	-0.532608747898718
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/222	122/9376	0.692364495643184	HRAS/GSK3B	-0.532608747898718
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/222	65/9376	0.64975744975745	PNPLA2	-0.441249364453547
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/222	66/9376	0.63991263991264	HSD11B1	-0.457153106772932
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/222	66/9376	0.63991263991264	SMAD2	-0.457153106772932
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/222	68/9376	0.621091679915209	DHRS3	-0.488334134029813
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/222	181/9376	0.700014932059131	ATP6V0C/LAMP2/PPP3R1	-0.634628731277117
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/222	69/9376	0.612090351220786	HRAS	-0.503624607665231
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/222	69/9376	0.612090351220786	PPP3R1	-0.503624607665231
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/222	70/9376	0.603346203346203	HSD11B1	-0.518723332021189
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/222	71/9376	0.594848369496257	HRAS	-0.53363615714615
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/222	72/9376	0.586586586586587	OTUD5	-0.548368667383238
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/222	191/9376	0.663364935616244	GNG10/HRAS/PPP1CB	-0.731969736510384
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/222	75/9376	0.563123123123123	BCAT1	-0.591536489635215
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/222	75/9376	0.563123123123123	CDKN1A	-0.591536489635215
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/222	75/9376	0.563123123123123	CGA	-0.591536489635215
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/222	78/9376	0.541464541464541	CDIPT	-0.633260102791412
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/222	78/9376	0.541464541464541	LSM2	-0.633260102791412
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/222	78/9376	0.541464541464541	C1R	-0.633260102791412
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/222	79/9376	0.534610559927016	HSD11B1	-0.64686749170664
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/222	254/9376	0.665106050932823	PPP3R1/PDGFD/ATP2B1/PHKB	-0.842627825499937
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/222	143/9376	0.590688590688591	C7/C1R	-0.768081178153708
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/222	201/9376	0.630361704988571	GADD45A/CCND2/CDKN1A	-0.824951890229432
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/222	82/9376	0.515051637002856	NME2	-0.68684345023604
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/222	83/9376	0.508846195593184	ECH1	-0.69989882009559
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/222	149/9376	0.566902472942741	HRAS/PDGFD	-0.829860797832955
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/222	86/9376	0.4910957469097	GABRA4	-0.738302128436884
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/222	154/9376	0.548496548496548	PPP1CB/ATP2B1	-0.879762705198593
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/222	158/9376	0.534610559927016	HRAS/GSK3B	-0.918720458714986
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/222	93/9376	0.454131550905744	PPP3R1	-0.823838271847396
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/222	93/9376	0.454131550905744	ATP2B1	-0.823838271847396
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/222	163/9376	0.518211462996739	HRAS/CDKN1A	-0.966287587441109
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/222	97/9376	0.43540447664159	GNG10	-0.870421042293784
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/222	98/9376	0.430961573818717	CDIPT	-0.881828477469627
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/222	98/9376	0.430961573818717	CDC42	-0.881828477469627
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/222	98/9376	0.430961573818717	ATP2B1	-0.881828477469627
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/222	99/9376	0.426608426608427	PPP1CB	-0.89314464073353
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/222	102/9376	0.414061119943473	ATP2B1	-0.926564225429124
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/222	298/9376	0.566902472942741	CCL4L2/CXCL14/CCL3L1/CCL4	-1.18319252744751
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/222	110/9376	0.383947583947584	CCNB1	-1.01210257819583
NA	NA	hsa04082	Neuroactive ligand signaling	2/222	199/9376	0.424464665670696	GNG10/GABRA4	-1.27792343815605
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/222	217/9376	0.389255615062067	HRAS/KLF5	-1.41749648828281
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/222	144/9376	0.293293293293293	GSK3B	-1.33085037818154
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/222	157/9376	0.269007861364549	THBS1	-1.43839212440389
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/222	370/9376	0.342439737034332	APELA/CGA/GABRA4	-2.00968098130855