category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 14/197 100/9376 6.66314720812183 HLA-DPA1/HLA-DQA2/CD44/HLA-DRB5/HLA-DRA/CSF3R/HLA-DPB1/CD7/ANPEP/IL1B/IL7R/CD36/CD2/IL3RA 8.34062407329085 Human Diseases Immune disease hsa05332 Graft-versus-host disease 10/197 45/9376 10.5764241398759 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/KLRC1/GZMB/IL1B/PRF1/KLRD1 9.43336418705905 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 12/197 95/9376 6.01186214266631 HLA-DPA1/HLA-DQA2/CXCL8/HLA-DRB5/HLA-DRA/CXCL2/HLA-DPB1/IL1B/CXCL12/CCL5/VEGFA/IL15 7.19257831552857 Organismal Systems Immune system hsa04612 Antigen processing and presentation 11/197 82/9376 6.38454871858363 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HSPA6/CD74/HLA-DPB1/KLRC1/KLRD1/KLRC3/IFI30 7.17424112617402 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 8/197 44/9376 8.65343793262575 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/GZMB/IL1B/PRF1 7.45446712964632 Cellular Processes Transport and catabolism hsa04145 Phagosome 14/197 155/9376 4.29880465040118 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/TUBA4A/THBS1/FCGR3B/ACTB/HLA-DPB1/CD36/C3/PLA2R1/OLR1/SEC22B 6.0667277016161 Organismal Systems Immune system hsa04672 Intestinal immune network for IgA production 8/197 50/9376 7.61502538071066 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/CXCR4/HLA-DPB1/CXCL12/IL15 6.87052426541688 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 9/197 66/9376 6.49007844946931 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/IL1B/STAT4/RORA/IL2RG 6.55687257718901 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 17/197 238/9376 3.39956490210297 CXCL8/RPL39/RPL37/RPL34/RPS4X/C7/IL1B/RPL28/C3/RPL30/RPS15A/RPS21/RPS27/RPS29/RPS8/RPL41/VWF 5.49308689292013 Human Diseases Immune disease hsa05330 Allograft rejection 7/197 39/9376 8.54249642066901 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/GZMB/PRF1 6.91456403945702 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 9/197 70/9376 6.11921682378535 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/ACTB/FYN/HLA-DPB1/PRF1/LAMA2 6.29784672472533 NA NA hsa04518 Integrin signaling 13/197 154/9376 4.01766761157624 ITGAX/THBS1/ACTB/FLNA/C3/CCND2/LAMA2/VEGFA/COL6A1/ITGB8/COL1A1/COL6A3/VWF 5.53146628262577 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 11/197 112/9376 4.67440174039159 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HSPA6/HLA-DPB1/PPIF/LAMA2/LDLR/MAP2K3/SOCS1 5.73082890373772 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 15/197 203/9376 3.51679127803756 THBS1/ACTB/FYN/FLNA/MYL9/BRAF/CCND2/LAMA2/VEGFA/COL6A1/ITGB8/EMP1/COL1A1/COL6A3/VWF 5.31080785321452 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 10/197 100/9376 4.75939086294416 CXCL8/XCL1/CX3CR1/CXCR4/CXCL2/XCL2/TNFSF14/CXCL12/IL2RG/CCL5 5.53679160722025 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 18/197 298/9376 2.8747998501005 CXCL8/XCL1/CX3CR1/CXCR4/CSF3R/CXCL2/XCL2/TNFSF14/IL1B/IL7R/TNFRSF18/CXCL12/IL2RG/CCL5/PRL/IL3RA/IL32/IL15 4.81824655224323 Organismal Systems Immune system hsa04659 Th17 cell differentiation 10/197 109/9376 4.36641363572859 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/IL1B/RORA/IL2RG/CD247/AHR 5.17883662951196 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 9/197 89/9376 4.812867164775 CD44/THBS1/CD36/LAMA2/COL6A1/ITGB8/COL1A1/COL6A3/VWF 5.29456180348094 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 13/197 181/9376 3.41834702863393 ITGAX/HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/CD74/FCGR3B/HLA-DPB1/IL1B/CLEC4E/C3/PLA2R1/LSP1 4.81285866707314 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 15/197 233/9376 3.06398553408422 VIM/DCN/VCAN/THBS1/ACTB/TPM2/MYL9/PDLIM1/LAMA2/NID1/COL6A1/ITGB8/FBLN2/COL1A1/COL6A3 4.67370520926063 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 7/197 54/9376 6.16958074826095 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/GZMB/PRF1 5.58108607218884 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 9/197 93/9376 4.60586212542983 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/RUNX3/STAT4/IL2RG/CD247 5.11949923364029 NA NA hsa04382 Cornified envelope formation 14/197 217/9376 3.07057475028656 S100A8/S100A6/S100A12/KRT24/S100A10/KRT6A/SPRR3/KRT5/S100A4/KRT81/KRT86/KRT17/S100A16/S100A9 4.52082626499719 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 8/197 78/9376 4.88142652609658 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/FCGR3B/HLA-DPB1/IL1B/C3 5.04272129991744 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 9/197 99/9376 4.32671896631287 KRT24/HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/FCGR3B/HLA-DPB1/C3/KRT17 4.87473486491956 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 10/197 133/9376 3.57848937063471 FCGR3B/FYN/CD48/KLRC1/GZMB/PRF1/BRAF/CD247/KLRD1/KLRC3 4.38738509753 Human Diseases Immune disease hsa05310 Asthma 5/197 32/9376 7.43654822335025 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1 5.34296916738933 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 8/197 88/9376 4.32671896631287 ITGAX/SERPINB2/PLAUR/CLU/C7/C3/F3/VWF 4.59322175655778 Human Diseases Infectious disease: bacterial hsa05134 Legionellosis 6/197 56/9376 5.09934735315446 CXCL8/HSPA6/CXCL2/IL1B/C3/SEC22B 4.5073558141116 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 12/197 204/9376 2.7996416840848 LUM/DCN/CD44/THBS1/ACTB/PLAUR/FLNA/BRAF/VEGFA/EZR/COL1A1/DDX5 3.80706394062644 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 12/197 205/9376 2.78598489538195 VIM/HLA-DPA1/HLA-DQA2/CD44/HLA-DRB5/HLA-DRA/HLA-DPB1/RUNX3/TNFAIP3/CCND2/CD247/MAP2K3 3.78762898860931 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 11/197 180/9376 2.90851663846588 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/CD74/HLA-DPB1/TNFSF14/IL1B/C3/CCL5/CFP 3.78750999938181 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 17/197 362/9376 2.23507305718372 EREG/THBS1/CSF3R/AREG/IL7R/CCND2/IL2RG/LAMA2/VEGFA/COL6A1/ITGB8/PRL/COL1A1/COL6A3/IL3RA/CREB5/VWF 3.51082532586218 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 10/197 160/9376 2.9746192893401 VCAN/HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/SELL/ITGB8/CD2/VSIR 3.69056789837096 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 12/197 216/9376 2.64410603496898 SOD2/CXCL8/HSPA6/CXCL2/IL1B/CD36/CCL5/LDLR/OLR1/ERN1/MAP2K3/EIF2AK3 3.58121197956117 Cellular Processes Cell growth and death hsa04210 Apoptosis 9/197 137/9376 3.12660713624069 CTSW/TUBA4A/ACTB/GZMB/BCL2A1/PRF1/ERN1/IL3RA/EIF2AK3 3.67329775409219 Organismal Systems Immune system hsa04062 Chemokine signaling pathway 11/197 193/9376 2.71260619131533 CXCL8/XCL1/CX3CR1/CXCR4/CXCL2/XCL2/FGR/BRAF/CXCL12/CCL5/RASGRP2 3.52180202165051 Genetic Information Processing Translation hsa03010 Ribosome 12/197 222/9376 2.57264370969955 RPL39/RPL37/RPL34/RPS4X/RPL28/RPL30/RPS15A/RPS21/RPS27/RPS29/RPS8/RPL41 3.47394102734252 Human Diseases Infectious disease: viral hsa05164 Influenza A 10/197 173/9376 2.75109298436079 HLA-DPA1/HLA-DQA2/CXCL8/HLA-DRB5/HLA-DRA/ACTB/HLA-DPB1/IL1B/TPSB2/CCL5 3.40556061768449 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 7/197 94/9376 3.54422723836267 S100A8/JUND/CXCL8/CXCL2/TNFAIP3/IL1B/S100A9 3.63178481915928 Human Diseases Infectious disease: parasitic hsa05144 Malaria 5/197 50/9376 4.75939086294416 CXCL8/THBS1/IL1B/CD36/ACKR1 3.90459365769954 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 7/197 105/9376 3.17292724196277 CXCL8/CXCL2/TNFSF14/TNFAIP3/IL1B/BCL2A1/CXCL12 3.2801794996702 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 9/197 168/9376 2.54967367657723 CSF3R/IL7R/STAT4/CCND2/IL2RG/PRL/IL3RA/SOCS1/IL15 2.96915799485879 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 10/197 201/9376 2.36785615071849 CXCL8/GZMB/BCL2A1/CCND2/JMJD1C/REL/DDX5/CDK14/IGFBP3/DUSP6 2.87181517622975 Human Diseases Cancer: specific types hsa05219 Bladder cancer 4/197 41/9376 4.64330815896991 CXCL8/THBS1/BRAF/VEGFA 3.42493031777872 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 8/197 143/9376 2.66259628696177 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/FCGR3B/HLA-DPB1/C7/C3 2.93497545464648 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 13/197 300/9376 2.0624027072758 JUND/EREG/HSPA6/AREG/FLNA/IL1B/PTPN7/BRAF/VEGFA/RASGRP2/MAP2K3/MAP3K2/DUSP6 2.73983001336581 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 7/197 119/9376 2.7996416840848 CXCL2/TNFAIP3/IL1B/CCL5/MAP2K3/CREB5/IL15 2.89431275897821 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 10/197 232/9376 2.05146157885524 ITGAX/CXCR4/ACTB/MYL9/C7/BRAF/CXCL12/ITGB8/EZR/RGCC 2.37569321856915 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 7/197 142/9376 2.34617859440909 JUND/FCGR3B/FYN/FOSL2/IL1B/LILRA5/SOCS1 2.36795248689123 Organismal Systems Environmental adaptation hsa04710 Circadian rhythm 3/197 34/9376 4.1994625261272 RORB/RORA/NFIL3 2.737900248819 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 6/197 116/9376 2.46175389462629 CXCR4/ACTB/MYL9/RHOH/CXCL12/EZR 2.32069906483703 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 9/197 224/9376 1.91225525743292 HLA-DPA1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DPB1/CCND2/IL2RG/CREB5/IL15 2.02443317088723 Organismal Systems Immune system hsa04611 Platelet activation 6/197 126/9376 2.26637660140198 ACTB/FYN/RASGRP2/COL1A1/PRKG1/VWF 2.09651681550563 NA NA hsa04517 IgSF CAM signaling 11/197 299/9376 1.75094647131725 ITGAX/TUBA4A/ACTB/FYN/CD48/MYL9/CD96/CRTAM/CD2/EZR/SLIT2 1.93327873372911 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 5/197 101/9376 2.35613409056642 CXCL8/IL1B/VEGFA/F3/COL1A1 2.0073699914845 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 5/197 103/9376 2.31038391405056 CXCL8/IL1B/C3/CCL5/CD247 1.95897142891806 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 5/197 103/9376 2.31038391405056 CXCL8/CXCL2/IL1B/LAMA2/COL1A1 1.95897142891806 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 2/197 21/9376 4.53275320280396 CSGALNACT2/DSE 2.37422632796557 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 9/197 248/9376 1.72719829703619 S100A10/CXCL8/TUBA4A/ACTB/FLNA/MYL9/IL1B/RHOH/MAP2K3 1.70024671424564 Human Diseases Neurodegenerative disease hsa05020 Prion disease 9/197 275/9376 1.55761882787264 TUBA4A/HSPA6/FYN/PPIF/C7/IL1B/CCL5/EIF2AK3/CREB5 1.37492904139633 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 3/197 59/9376 2.42002925234449 MGST1/ANPEP/GPX1 1.60289958068188 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 3/197 62/9376 2.30293106271492 CRYAB/SOD2/HSPA6 1.50789198356489 Genetic Information Processing Folding, sorting and degradation hsa04130 SNARE interactions in vesicular transport 2/197 33/9376 2.88447931087525 STX11/SEC22B 1.58864271546796 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 4/197 99/9376 1.92298620725017 ACTB/TPM2/LAMA2/ITGB8 1.35247764836265 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 3/197 65/9376 2.19664193674346 GPAT3/PLPP1/GK 1.41822063529921 Human Diseases Infectious disease: viral hsa05162 Measles 5/197 136/9376 1.749776052553 HSPA6/TNFAIP3/IL1B/CCND2/IL2RG 1.29028634175213 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 7/197 212/9376 1.5714969830476 THBS1/ACTB/BRAF/SIPA1L1/VEGFA/RASGRP2/MAP2K3 1.23299239707151 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 10/197 333/9376 1.42924650538864 THBS1/CCND2/LAMA2/VEGFA/COL6A1/ITGB8/COL1A1/COL6A3/CREB5/VWF 1.16840575067641 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 4/197 103/9376 1.84830713124045 COL6A1/COL15A1/COL1A1/COL6A3 1.26818515950079 Human Diseases Cancer: specific types hsa05221 Acute myeloid leukemia 3/197 68/9376 2.0997312630636 BCL2A1/BRAF/DUSP6 1.33331850508885 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 4/197 105/9376 1.81310128112159 ACTB/TPM2/LAMA2/ITGB8 1.22743095212035 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 5/197 144/9376 1.65256627185561 CXCL8/CXCL2/IL1B/C3/MAP2K3 1.1560564413 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 3/197 71/9376 2.01101022377922 CCND2/PRL/SOCS1 1.25270150552295 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 3/197 71/9376 2.01101022377922 CXCL8/CXCL2/CCL5 1.25270150552295 Human Diseases Immune disease hsa05340 Primary immunodeficiency 2/197 38/9376 2.5049425594443 IL7R/IL2RG 1.361776558449 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 4/197 109/9376 1.74656545429144 CXCL8/IL1B/CCL5/MAP2K3 1.14850429548475 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 6/197 187/9376 1.52707728222807 CXCL8/CXCL2/NAMPT/TNFAIP3/IL1B/CCL5 1.06655201802308 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 7/197 227/9376 1.46765357007089 CXCL8/CXCR4/IL1B/CXCL12/CCL5/VEGFA/CREB5 1.04489207494095 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 3/197 75/9376 1.90375634517767 THBS1/CCND2/IGFBP3 1.15116674535646 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 3/197 76/9376 1.87870691958322 CD36/OLR1/GK 1.12675744045876 Cellular Processes Cell growth and death hsa04216 Ferroptosis 2/197 42/9376 2.26637660140198 SAT1/FTH1 1.20496571711674 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 4/197 115/9376 1.65544030015449 JUND/BRAF/PDE4B/CREB5 1.03603442243101 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 3/197 78/9376 1.83053494728622 CXCL8/IL1B/C3 1.0790250030104 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 6/197 195/9376 1.46442795782897 FCGR3B/ACTB/AQP9/PPIF/C3/VWF 0.960089530877346 Organismal Systems Digestive system hsa04975 Fat digestion and absorption 2/197 43/9376 2.21367016881124 CD36/PLPP1 1.16854472327357 Cellular Processes Cell growth and death hsa04218 Cellular senescence 5/197 157/9376 1.51572957418604 CXCL8/CCND2/ZFP36L2/MAP2K3/IGFBP3 0.954665045748554 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 6/197 200/9376 1.42781725888325 CXCL8/TUBA4A/ACTB/FYN/IL1B/EZR 0.895916763005558 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 4/197 122/9376 1.56045602063743 MAP2K3/SOCS1/CREB5/IGFBP3 0.912804501191605 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 5/197 163/9376 1.45993584752888 CXCL8/STAT4/BRAF/MAP2K3/CREB5 0.867783908991215 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 3/197 86/9376 1.66025262660843 EREG/AREG/BRAF 0.901099134523376 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 3/197 86/9376 1.66025262660843 ACTB/LAMA2/ITGB8 0.901099134523376 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 3/197 87/9376 1.64116926308419 EREG/AREG/BRAF 0.880174750480026 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 7/197 253/9376 1.31682751148653 CD44/CXCL8/ACTB/MYL9/IL1B/C3/CCL5 0.74840275183677 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 5/197 170/9376 1.3998208420424 TUBA4A/ACTB/MYL9/EZR/YBX3 0.77068245337262 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 3/197 89/9376 1.604289054925 TUBA4A/PRKG1/MAP3K2 0.83911807314596 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 2/197 52/9376 1.83053494728622 CD36/LDLR 0.879791004495584 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 4/197 133/9376 1.43139574825388 SOD2/IL7R/BRAF/CCND2 0.734034159140626 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 3/197 93/9376 1.53528737514328 ACTB/FYN/MYL9 0.759985604412611 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 4/197 134/9376 1.42071369043109 MYL9/BRAF/CALD1/PRKG1 0.718583313478567 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 2/197 56/9376 1.69978245105149 GAS1/CCND2 0.769431869912912 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 4/197 138/9376 1.37953358346208 CXCL8/ACTB/IL1B/MAP2K3 0.657993860775664 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 4/197 139/9376 1.36960888142278 KRT24/HSPA6/KRT17/CREB5 0.643139810157108 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 6/197 227/9376 1.25798877434647 SOD2/MGST1/PPIF/BRAF/VEGFA/AHR 0.576431878190297 NA NA hsa04519 Cadherin signaling 10/197 404/9376 1.17806704528321 VIM/KRT24/ACTB/KRT6A/KRT5/KRT81/CDH11/KRT86/KRT17/MAP2K3 0.53598257253107 Organismal Systems Development and regeneration hsa04360 Axon guidance 5/197 184/9376 1.2933127344957 CXCR4/FYN/MYL9/CXCL12/SLIT2 0.588648292754414 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 4/197 142/9376 1.34067348251948 ACTB/MGST1/IL1B/VEGFA 0.599250815233773 Metabolism Metabolism of cofactors and vitamins hsa00770 Pantothenate and CoA biosynthesis 1/197 21/9376 2.26637660140198 VNN2 0.851082568061006 Organismal Systems Nervous system hsa04730 Long-term depression 2/197 60/9376 1.58646362098139 BRAF/PRKG1 0.667610301052375 Organismal Systems Digestive system hsa04978 Mineral absorption 2/197 61/9376 1.56045602063743 FTH1/MT2A 0.643333390867952 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 8/197 323/9376 1.17879649856202 VIM/CD44/THBS1/CCND2/VEGFA/GLS/EZR/SOCS1 0.479054668612519 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 3/197 105/9376 1.35982596084119 ARIH1/EIF2AK3/RABGEF1 0.543181436270392 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 3/197 105/9376 1.35982596084119 IL1B/CLEC4E/LSP1 0.543181436270392 Metabolism Amino acid metabolism hsa00220 Arginine biosynthesis 1/197 23/9376 2.06930037519311 GLS 0.752158272508665 Organismal Systems Endocrine system hsa04614 Renin-angiotensin system 1/197 23/9376 2.06930037519311 ANPEP 0.752158272508665 Organismal Systems Excretory system hsa04964 Proximal tubule bicarbonate reclamation 1/197 23/9376 2.06930037519311 GLS 0.752158272508665 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 5/197 196/9376 1.21413032217963 CXCL8/CXCL2/C3/CLEC2B/VEGFA 0.443819042226024 Organismal Systems Endocrine system hsa04927 Cortisol synthesis and secretion 2/197 65/9376 1.46442795782897 LDLR/CREB5 0.550424728716598 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 3/197 110/9376 1.29801568989386 DCN/THBS1/SKIL 0.460585636629456 Human Diseases Endocrine and metabolic disease hsa04934 Cushing syndrome 4/197 155/9376 1.22822990011462 BRAF/LDLR/AHR/CREB5 0.419730418772773 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 4/197 157/9376 1.21258365934883 CX3CR1/THBS1/CD36/MFGE8 0.393512800187872 Environmental Information Processing Signal transduction hsa04390 Hippo signaling pathway 4/197 157/9376 1.21258365934883 ACTB/AREG/CCND2/CCN2 0.393512800187872 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 4/197 157/9376 1.21258365934883 CXCL8/IL1B/ERN1/EIF2AK3 0.393512800187872 Organismal Systems Immune system hsa04664 Fc epsilon RI signaling pathway 2/197 69/9376 1.37953358346208 FYN/MAP2K3 0.463544001805215 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 2/197 70/9376 1.35982596084119 MGST1/HSD11B1 0.44267098405087 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 2/197 70/9376 1.35982596084119 BRAF/VEGFA 0.44267098405087 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 2/197 71/9376 1.34067348251948 SLC7A5/GLS 0.422114608147716 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 2/197 73/9376 1.30394270217648 APOBEC3A/CXCR4 0.381911473821773 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 4/197 166/9376 1.14684117179377 PPIF/MYL9/PRKG1/CREB5 0.27963603578361 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 2/197 75/9376 1.26917089678511 GPX1/CREB5 0.342858544617888 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 7/197 308/9376 1.08167974157822 SOD2/TUBA4A/PPIF/TGM2/ERN1/GPX1/CREB5 0.21352809422157 Human Diseases Drug resistance: antineoplastic hsa01523 Antifolate resistance 1/197 30/9376 1.58646362098139 IL1B 0.471313503554674 Cellular Processes Cell growth and death hsa04217 Necroptosis 4/197 168/9376 1.13318830070099 TNFAIP3/IL1B/FTH1/STAT4 0.255187342874309 Organismal Systems Digestive system hsa04971 Gastric acid secretion 2/197 76/9376 1.25247127972215 ACTB/EZR 0.323741496270455 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 2/197 77/9376 1.23620541894654 BRAF/VEGFA 0.304886476938393 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 2/197 79/9376 1.20490907922637 MGST1/HSD11B1 0.267931884253184 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 4/197 174/9376 1.09411284205613 CRYAB/HSPA6/ERN1/EIF2AK3 0.183570742542248 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 2/197 80/9376 1.18984771573604 BRAF/VEGFA 0.249817799369475 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 3/197 130/9376 1.09832096837173 VEGFA/COL1A1/CREB5 0.16537198724061 Metabolism Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes 2/197 82/9376 1.16082703974248 MGST1/UPP1 0.214282017495575 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 5/197 226/9376 1.05296258029738 MYL9/BRAF/HCAR3/PDE4B/CREB5 0.11806845339116 Organismal Systems Immune system hsa04623 Cytosolic DNA-sensing pathway 2/197 83/9376 1.14684117179377 IL1B/CCL5 0.196847537141876 Metabolism Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism 1/197 37/9376 1.28632185484977 GLS 0.2556384875976 Human Diseases Infectious disease: parasitic hsa05143 African trypanosomiasis 1/197 37/9376 1.28632185484977 IL1B 0.2556384875976 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 1/197 37/9376 1.28632185484977 BRAF 0.2556384875976 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 1/197 38/9376 1.25247127972215 NAMPT 0.22845355010373 Organismal Systems Nervous system hsa04727 GABAergic synapse 2/197 89/9376 1.06952603661667 GLS/SLC38A1 0.0965441180901298 Organismal Systems Aging hsa04211 Longevity regulating pathway 2/197 90/9376 1.05764241398759 SOD2/CREB5 0.0804952292530832 Organismal Systems Digestive system hsa04976 Bile secretion 2/197 90/9376 1.05764241398759 AQP9/LDLR 0.0804952292530832 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 2/197 90/9376 1.05764241398759 CD247/MAP2K3 0.0804952292530832 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 2/197 91/9376 1.04601996987784 IFITM1/LILRA5 0.0646244914534752 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 2/197 93/9376 1.02352491676219 MAP2K3/MAP3K2 0.0333999995413312 Organismal Systems Digestive system hsa04970 Salivary secretion 2/197 93/9376 1.02352491676219 LYZ/PRKG1 0.0333999995413312 Cellular Processes Cell motility hsa04814 Motor proteins 4/197 194/9376 0.981317703699827 TUBA4A/ACTB/TPM2/MYL9 -0.0385197573592904 Human Diseases Neurodegenerative disease hsa05017 Spinocerebellar ataxia 3/197 144/9376 0.991539763113367 PPIF/RORA/ERN1 -0.0149877671732929 Cellular Processes Transport and catabolism hsa04144 Endocytosis 5/197 250/9376 0.951878172588833 HSPA6/CXCR4/VPS37B/IL2RG/LDLR -0.112977757367017 Organismal Systems Excretory system hsa04962 Vasopressin-regulated water reabsorption 1/197 44/9376 1.08167974157822 CREB5 0.0795562666232981 Environmental Information Processing Signal transduction hsa04072 Phospholipase D signaling pathway 3/197 149/9376 0.958266616700167 CXCL8/FYN/PLPP1 -0.0752259246054562 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 2/197 98/9376 0.971304257743707 FCGR3B/PLPP1 -0.04183351749559 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 2/197 98/9376 0.971304257743707 LDLR/CREB5 -0.04183351749559 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 2/197 99/9376 0.961493103625083 IL1B/MAP2K3 -0.0564252382601159 Metabolism Metabolism of cofactors and vitamins hsa00860 Porphyrin metabolism 1/197 46/9376 1.03465018759656 FTH1 0.034511572692977 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 4/197 205/9376 0.928661631793983 C3/CCND2/REL/CREB5 -0.151290905155953 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 3/197 154/9376 0.927154064209902 TPM2/CREB5/KCNE1 -0.133528568919748 Human Diseases Endocrine and metabolic disease hsa04930 Type II diabetes mellitus 1/197 47/9376 1.01263635381791 SOCS1 0.012722551760379 NA NA hsa03272 Virion - Hepatitis viruses 1/197 48/9376 0.991539763113367 LDLR -0.00860854868218062 Metabolism Lipid metabolism hsa00564 Glycerophospholipid metabolism 2/197 104/9376 0.915267473643108 GPAT3/PLPP1 -0.12729202044952 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/197 49/9376 0.971304257743707 CREB5 -0.0295029593478752 Metabolism Amino acid metabolism hsa00330 Arginine and proline metabolism 1/197 50/9376 0.951878172588833 SAT1 -0.0499804859235642 Human Diseases Cancer: specific types hsa05215 Prostate cancer 2/197 106/9376 0.8979982760272 BRAF/CREB5 -0.154718285415674 Metabolism Lipid metabolism hsa00565 Ether lipid metabolism 1/197 51/9376 0.933213894694934 PLPP1 -0.0700596320463418 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/197 51/9376 0.933213894694934 ACTB -0.0700596320463418 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 4/197 214/9376 0.88960576877461 APOBEC3A/CXCR4/CD247/MAP2K3 -0.239320107222334 Organismal Systems Endocrine system hsa04913 Ovarian steroidogenesis 1/197 52/9376 0.915267473643108 LDLR -0.0897577094384307 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 2/197 109/9376 0.873282727145718 CD36/CREB5 -0.194939815857651 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 4/197 217/9376 0.877307071510445 MGST1/VEGFA/AHR/CREB5 -0.267883790994863 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 2/197 110/9376 0.865343793262575 TIMP1/VEGFA -0.208112246467134 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 9/197 480/9376 0.89238578680203 DKK1/TUBA4A/PPIF/IL1B/BRAF/ERN1/GPX1/MAP2K3/EIF2AK3 -0.354579752622535 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 1/197 55/9376 0.865343793262575 PLPP1 -0.146722775351063 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 3/197 170/9376 0.83989250522544 ACTB/MGST1/BRAF -0.308618320760567 Organismal Systems Nervous system hsa04725 Cholinergic synapse 2/197 115/9376 0.827720150077246 FYN/CREB5 -0.272317486076384 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 2/197 116/9376 0.820584631542097 GLS/SLC38A1 -0.28484211968123 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 7/197 388/9376 0.858652990737349 DKK1/TUBA4A/PPIF/IL1B/BRAF/ERN1/EIF2AK3 -0.416573866270383 Metabolism Nucleotide metabolism hsa00240 Pyrimidine metabolism 1/197 59/9376 0.806676417448163 UPP1 -0.218219652092831 Organismal Systems Endocrine system hsa04923 Regulation of lipolysis in adipocytes 1/197 59/9376 0.806676417448163 PRKG1 -0.218219652092831 Human Diseases Cancer: specific types hsa05213 Endometrial cancer 1/197 59/9376 0.806676417448163 BRAF -0.218219652092831 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 1/197 60/9376 0.793231810490694 VEGFA -0.235377896100981 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 2/197 120/9376 0.793231810490694 BRAF/IRAK3 -0.333951763686413 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 3/197 178/9376 0.802144527462499 DKK1/CCND2/NOTUM -0.390420336941067 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 2/197 122/9376 0.780228010318715 CD36/CREB5 -0.357938632167339 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 2/197 122/9376 0.780228010318715 FYN/CD247 -0.357938632167339 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 4/197 235/9376 0.810109083054325 ACTB/MAP2K3/PRKG1/CREB5 -0.431879246152457 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 1/197 63/9376 0.755458867133994 PTGDS -0.285297824093799 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 4/197 238/9376 0.799897624024229 VEGFA/REL/RALGAPA1/RASGRP2 -0.458074602504548 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 2/197 125/9376 0.761502538071066 FYN/S1PR3 -0.393247068713716 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 1/197 66/9376 0.721119827718812 HSD11B1 -0.333070241305754 Organismal Systems Nervous system hsa04720 Long-term potentiation 1/197 67/9376 0.710356845215547 BRAF -0.34855412090772 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/197 69/9376 0.689766791731038 CREB5 -0.378903868116416 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 1/197 70/9376 0.679912980420595 CD36 -0.393782693188339 Organismal Systems Immune system hsa04622 RIG-I-like receptor signaling pathway 1/197 72/9376 0.661026508742245 CXCL8 -0.422978409778406 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/197 73/9376 0.651971351088241 MGST1 -0.43730654918279 Human Diseases Cancer: specific types hsa05218 Melanoma 1/197 73/9376 0.651971351088241 BRAF -0.43730654918279 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 1/197 73/9376 0.651971351088241 BRAF -0.43730654918279 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 2/197 138/9376 0.689766791731038 BRAF/SOCS1 -0.537848441731144 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 6/197 368/9376 0.775987640697418 TUBA4A/ACTB/ERN1/GPX1/MAP2K3/EIF2AK3 -0.642248009589653 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/197 75/9376 0.634585448392555 MGST1 -0.465449656120688 Human Diseases Cancer: specific types hsa05214 Glioma 1/197 76/9376 0.626235639861074 BRAF -0.479274447917849 Human Diseases Cancer: specific types hsa05220 Chronic myeloid leukemia 1/197 77/9376 0.618102709473268 BRAF -0.492940932432071 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 3/197 205/9376 0.696496223845487 PPIF/CD36/COL1A1 -0.643655891876611 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 2/197 144/9376 0.661026508742245 SKIL/JARID2 -0.600509871409941 Genetic Information Processing Folding, sorting and degradation hsa03018 RNA degradation 1/197 78/9376 0.610178315762072 BTG1 -0.506453515752414 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 1/197 78/9376 0.610178315762072 ACTB -0.506453515752414 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 4/197 268/9376 0.710356845215547 TUBA4A/PPIF/ERN1/EIF2AK3 -0.70475833611261 Genetic Information Processing Chromosome hsa03083 Polycomb repressive complex 1/197 83/9376 0.573420585896887 JARID2 -0.571849884033564 Cellular Processes Transport and catabolism hsa04146 Peroxisome 1/197 83/9376 0.573420585896887 SOD2 -0.571849884033564 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/197 85/9376 0.55992833681696 UPP1 -0.597066498895526 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 2/197 154/9376 0.618102709473268 ACTB/MYL9 -0.7000280540743 Organismal Systems Endocrine system hsa04911 Insulin secretion 1/197 86/9376 0.55341754220281 CREB5 -0.609486505614506 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 1/197 87/9376 0.547056421028065 TPM2 -0.621785111290968 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 2/197 156/9376 0.610178315762072 BRAF/LDLR -0.719256670902496 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 2/197 158/9376 0.602454539613185 SLC7A5/BRAF -0.738274820187394 Human Diseases Substance dependence hsa05032 Morphine addiction 1/197 91/9376 0.523009984938919 PDE4B -0.669823062325655 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/197 93/9376 0.511762458381093 LAMA2 -0.693185605329949 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 1/197 97/9376 0.490658851849914 PRKG1 -0.738694914353457 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 2/197 169/9376 0.563241522241913 ERN1/EIF2AK3 -0.839356949899237 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 1/197 99/9376 0.480746551812542 BRAF -0.760876681571498 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/197 99/9376 0.480746551812542 PLPP1 -0.760876681571498 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 1/197 107/9376 0.444802884387305 CREB5 -0.846142901317564 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 1/197 110/9376 0.432671896631287 BRAF -0.876810129563725 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 3/197 254/9376 0.562132779087893 CXCR4/PPIF/VEGFA -1.03641890325789 Human Diseases Substance dependence hsa05034 Alcoholism 2/197 191/9376 0.498365535386823 BRAF/CREB5 -1.02609019240252 Organismal Systems Nervous system hsa04726 Serotonergic synapse 1/197 115/9376 0.413860075038623 BRAF -0.926493440330081 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/197 117/9376 0.406785543841381 ACTB -0.945896636281493 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 1/197 122/9376 0.390114005159358 ACTB -0.993310198846812 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 1/197 128/9376 0.371827411167513 PDE4B -1.04828922554086 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 1/197 133/9376 0.357848937063471 CREB5 -1.09264131005406 NA NA hsa04081 Hormone signaling 2/197 219/9376 0.434647567392161 PRL/PRKG1 -1.24018302280073 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 1/197 140/9376 0.339956490210297 CCN2 -1.15269839130525 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 1/197 142/9376 0.335168370629871 SOCS1 -1.16945085642369 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 4/197 370/9376 0.514528741939909 S1PR3/C3/GZMA/PRL -1.3957880635364 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/197 148/9376 0.321580463712443 BRAF -1.2186990618954 Human Diseases Cancer: specific types hsa05226 Gastric cancer 1/197 150/9376 0.317292724196278 BRAF -1.23479397579923 Genetic Information Processing Transcription hsa03040 Spliceosome 2/197 243/9376 0.391719412587997 HSPA6/DDX5 -1.40741258775177 Cellular Processes Cell growth and death hsa04110 Cell cycle 1/197 158/9376 0.301227269806593 CCND2 -1.29767878932244 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 2/197 250/9376 0.380751269035533 CTSW/SLC11A1 -1.45383782454823 Organismal Systems Sensory system hsa04740 Olfactory transduction 1/197 449/9376 0.105999796502097 PRKG1 -2.84399669338791