category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	112/1229	222/9376	3.84884803436471	RPL39/RPL28/RPL34/RPL30/RPL8/RPS13/RPS23/RPS15A/RPS12/RPL37/RPL11/RPS11/RPL19/RPS4X/RPL41/RPL14/RPS24/RPL10/FAU/RPS28/RPL32/RPLP1/RPS27/RPL35A/RPS27A/RPL18A/RPS8/RPL29/RPL9/RPS3A/RPL12/RPL26/RPS14/RPS21/UBA52/RPL18/RPL24/RPS7/RPS15/RPL23/RPL23A/RPL15/RPL7/RPL21/RPL37A/RPL36/RPS2/RPL22/RPS6/RPS5/RPS10/RPS3/RACK1/RPL27/RPL13/RPL10A/RPL27A/RPL13A/RPL3/RPS16/RPL5/RPSA/RPLP2/RPS20/RSL24D1/RPS19/MRPL33/RPS29/RPLP0/RPL35/RPL36AL/MRPS33/MRPL51/MRPL54/MRPL11/MRPS21/MRPL40/MRPL52/RPS27L/RPL38/MRPL18/RPL6/MRPL20/RPL22L1/MRPL43/RPL4/MRPL42/MRPS18C/MRPS35/MRPL16/MRPL36/MRPS22/MRPL13/MRPL55/MRPS15/MRPL44/MRPS23/MRPS11/DAP3/MRPL21/MRPL34/MRPL3/MRPL9/RPL31/RPL26L1/MRPS10/MRPL28/MRPS14/MRPS27/RPS10-NUDT3/RPL36A/MRPS16	16.6841097501066
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	92/1229	238/9376	2.94901231444571	RPL39/RPL28/RPL34/RPL30/RPL8/RPS13/RPS23/RPS15A/RPS12/RPL37/RPL11/RPS11/RPL19/RPS4X/RPL41/RPL14/RPS24/RPL10/FAU/RPS28/RPL32/RPLP1/RPS27/RPL35A/RPS27A/RPL18A/RPS8/RPL29/RPL9/RPS3A/RPL12/RPL26/RPS14/RPS21/UBA52/RPL18/RPL24/RPS7/RPS15/RPL23/RPL23A/RPL15/RPL7/RPL21/RPL37A/RPL36/RPS2/RPL22/RPS6/RPS5/RPS10/RPS3/RPL27/RPL13/RPL10A/RPL27A/RPL13A/RPL3/RPS16/RPL5/RPSA/RPLP2/RPS20/RSL24D1/RPS19/RPS29/RPLP0/RPL35/STAT1/CASP1/PRKCB/RPL36AL/TRAF3/TAB2/TLR2/C7/IL6/MAPK8/RPS27L/RPL38/RPL6/RPL22L1/RPL4/PRKCA/MMP1/OAS1/IL6ST/RPL31/RPL26L1/TLR7/RPS10-NUDT3/RPL36A	11.828786856394
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	63/1229	138/9376	3.48278911805285	COX7C/COX4I1/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/COX7A2/ATP5PB/ATP6V1G1/ATP5MC3/COX7A2L/UQCRB/ATP5MG/UQCRC2/ATP5F1C/COX5A/ATP5PO/NDUFA4/NDUFB3/ATP5F1D/PPA1/NDUFAB1/NDUFB11/UQCR10/SDHB/NDUFB4/ATP5F1E/ATP6V0E1/NDUFB10/NDUFS4/COX7B/UQCRFS1/COX17/COX5B/NDUFA2/NDUFS7/COX6C/PPA2/NDUFS6/ATP5PF/ATP6V1D/ATP5MC1/NDUFB7/NDUFS5/UQCRQ/ATP5ME/NDUFB2/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/ATP5F1A/ATP6V0C/NDUFC1/COX8A/NDUFA12/SDHC/COX11/NDUFA10/ATP5F1B	11.4117728623018
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	93/1229	268/9376	2.64736528909561	RPS27A/UBA52/COX7C/COX4I1/HSPA5/NDUFB1/ATP5MC2/CAMK2D/COX6B1/UQCRH/NDUFB5/SLC25A5/COX7A2/ATP5PB/ATP5MC3/UBE2L6/COX7A2L/UQCRB/PARK7/PSMB1/UQCRC2/ATP5F1C/UBC/PSMA7/COX5A/ATP5PO/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/VDAC2/NDUFAB1/EIF2AK3/NDUFB11/UQCR10/VDAC3/SDHB/NDUFB4/ATP5F1E/MCU/NDUFB10/SLC25A6/SLC39A9/NDUFS4/COX7B/UQCRFS1/PSMA1/TXN2/MAPK8/UBB/COX5B/PSMD12/NDUFA2/NDUFS7/COX6C/PSMD8/LRRK2/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/PRKN/PSMB7/ATP5MC1/NDUFB7/ATF6/NDUFS5/PSMD13/TXN/ITPR1/UQCRQ/EIF2S1/NDUFB2/SLC39A11/PSMB6/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/ERN1/ATP5F1A/NDUFC1/COX8A/GNAL/NDUFA12/SDHC/NDUFA10/ATP5F1B	10.6269470937179
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	77/1229	205/9376	2.86551429875568	COX7C/COX4I1/NDUFB1/ATP5MC2/CAMK2D/COX6B1/UQCRH/NDUFB5/NCF2/SLC25A5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/RAC2/UQCRC2/ATP5F1C/COX5A/PPP1CC/PRKCB/ATP5PO/PLCB1/NDUFA4/MPC1/NDUFB3/ATP5F1D/VDAC2/NDUFAB1/NDUFB11/UQCR10/VDAC3/SDHB/NDUFB4/ATP5F1E/NDUFB10/GAPDH/SLC25A6/NDUFS4/COX7B/UQCRFS1/MAPK8/COX5B/NDUFA2/NDUFS7/SMAD2/COX6C/NDUFS6/ATP5PF/PTEN/ATP5MC1/NDUFB7/NDUFS5/PPP1CA/CYBA/PRKCA/NCF4/ATP2A2/UQCRQ/MPC2/NDUFB2/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/GSK3B/ATP5F1A/NDUFC1/COX8A/NDUFA12/SDHC/PARP1/NDUFA10/ATP5F1B/INSR	10.4888986121921
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	111/1229	368/9376	2.30112852442778	NRG1/COX7C/COX4I1/GPX1/HSPA5/NDUFB1/ATP5MC2/RAB1A/COX6B1/UQCRH/NDUFB5/COX7A2/ATP5PB/NUP214/ATP5MC3/COX7A2L/UQCRB/PSMB1/UQCRC2/CASP1/MAP1LC3B/TANK/ATP5F1C/PSMA7/C9orf72/COX5A/ATP5PO/AMBRA1/DNAI2/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/NDUFAB1/EIF2AK3/BID/NDUFB11/UQCR10/SDHB/NDUFB4/ATP5F1E/MCU/NDUFB10/NDUFS4/NRBF2/COX7B/UQCRFS1/PSMA1/COX5B/DCTN3/PSMD12/ALYREF/NXT1/NDUFA2/NDUFS7/ACTG1/PPP3CC/COX6C/PSMD8/ACTR10/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/DCTN6/PPP3CB/PRKN/SPG11/PSMB7/ATP5MC1/NDUFB7/HNRNPA1/ATF6/SEC13/RAB8A/FIG4/NDUFS5/PSMD13/CHMP2B/WIPI1/NXF1/UQCRQ/CAT/EIF2S1/NDUFB2/PSMB6/UQCR11/NDUFS8/NDUFB6/MAP1LC3B2/NDUFA9/NDUFB9/SEH1L/ULK2/SDHD/ATXN2/ERN1/DCTN2/ATP5F1A/NDUFC1/COX8A/NUP210L/DERL1/NDUFA12/NUP37/SDHC/NDUFA10/ATP5F1B	9.88991684435051
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	91/1229	275/9376	2.5244944152674	COX7C/COX4I1/HSPA5/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/NCF2/SLC25A5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/RAC2/PSMB1/UQCRC2/ATP5F1C/PSMA7/COX5A/ATP5PO/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/VDAC2/NDUFAB1/EIF2AK3/NDUFB11/UQCR10/HSPA8/VDAC3/SDHB/NDUFB4/ATP5F1E/C7/MCU/NDUFB10/SLC25A6/NDUFS4/COX7B/UQCRFS1/PSMA1/IL6/MAPK8/FYN/COX5B/PRNP/PSMD12/CREB1/NDUFA2/NDUFS7/PPP3CC/COX6C/PSMD8/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/PPP3CB/PSMB7/ATP5MC1/NDUFB7/NDUFS5/PSMD13/CYBA/ITPR1/NCF4/UQCRQ/EIF2S1/ATF2/NDUFB2/PSMB6/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/GSK3B/ATP5F1A/NDUFC1/COX8A/NDUFA12/SDHC/NDUFA10/ATP5F1B	9.96575827611694
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	97/1229	308/9376	2.40262910401234	COX7C/COX4I1/GPX1/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/SLC25A5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/PSMB1/UQCRC2/ATP5F1C/PSMA7/COX5A/ATP5PO/PLCB1/AMBRA1/DNAI2/RCOR1/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/VDAC2/NDUFAB1/NDUFB11/UQCR10/VDAC3/POLR2L/SDHB/NDUFB4/ATP5F1E/NDUFB10/SLC25A6/NDUFS4/NRBF2/COX7B/UQCRFS1/PSMA1/CLTA/MAPK8/AP2S1/POLR2I/COX5B/DCTN3/PSMD12/CREB1/NRF1/NDUFA2/NDUFS7/COX6C/PSMD8/ACTR10/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/DCTN6/PSMB7/ATP5MC1/NDUFB7/NDUFS5/PSMD13/POLR2G/ITPR1/WIPI1/UQCRQ/POLR2F/NDUFB2/IFT57/PSMB6/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/ULK2/SDHD/GNAQ/ERN1/DCTN2/ATP5F1A/NDUFC1/COX8A/TAF4B/NDUFA12/SDHC/NDUFA10/ATP5F1B	9.72131845381211
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	131/1229	480/9376	2.08207214537564	RPS27A/UBA52/COX7C/COX4I1/GPX1/HSPA5/NDUFB1/ATP5MC2/RAB1A/CAMK2D/COX6B1/UQCRH/NDUFB5/SLC25A5/COX7A2/ATP5PB/ATP5MC3/UBE2L6/COX7A2L/UQCRB/PARK7/PSMB1/UQCRC2/MAP1LC3B/TANK/ATP5F1C/UBC/PTGS2/PSMA7/C9orf72/COX5A/PRKCB/ATP5PO/PLCB1/AMBRA1/DNAI2/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/VDAC2/NDUFAB1/EIF2AK3/BID/NDUFB11/UQCR10/VDAC3/SDHB/NDUFB4/ATP5F1E/CTNNB1/MCU/NDUFB10/SLC25A6/NDUFS4/NRBF2/COX7B/UQCRFS1/PSMA1/ATXN1/IL6/MAPK8/UBB/COX5B/PRNP/DCTN3/PSMD12/NDUFA2/NDUFS7/MAP2K1/PPP3CC/COX6C/PSMD8/ACTR10/LRRK2/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/DCTN6/PPP3CB/PRKN/FRAT2/DKK1/SPG11/PSMB7/ATP5MC1/NDUFB7/ATF6/RAB8A/HSD17B10/ATXN3/FIG4/NDUFS5/PSMD13/ITPR1/CHMP2B/WIPI1/PRKCA/ATP2A2/UQCRQ/CAT/EIF2S1/NDUFB2/IFT57/PSMB6/UQCR11/NDUFS8/NDUFB6/MAP1LC3B2/NDUFA9/NDUFB9/ULK2/SDHD/GNAQ/ATXN2/ERN1/DCTN2/GSK3B/ATP5F1A/NDUFC1/COX8A/DERL1/TPTEP2-CSNK1E/NDUFA12/SDHC/NDUFA10/ATP5F1B	9.45240172256219
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	81/1229	235/9376	2.62955871405571	RPS6/COX7C/COX4I1/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/ATP5MG/UQCRC2/ADCY3/ATP5F1C/ACSL5/COX5A/ATP5PO/NDUFA4/COA1/NDUFB3/ATP5F1D/RPTOR/NDUFAB1/ACSL3/NDUFB11/COX14/UQCR10/SDHB/NDUFB4/ATP5F1E/NDUFB10/NDUFS4/ZNF516/COX7B/UQCRFS1/NDUFAF2/COX17/COX5B/CREB1/NDUFA2/COA3/NDUFS7/ACTG1/COA4/COX6C/ARID1A/SOS1/NDUFS6/ATP5PF/RHEB/ATP5MC1/NDUFB7/FRS2/NDUFS5/KDM3B/UQCRQ/ATF2/ATP5ME/NDUFB2/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/SMARCC1/ATP5F1A/ACTL6A/NDUFC1/COX8A/NDUFA12/RPS6KA2/SDHC/COX11/NDUFA10/COA5/ATP5F1B/COA6	9.82584278661249
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	76/1229	227/9376	2.55419147403247	COX7C/COX4I1/FOXO3/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/NCF2/SLC25A5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/UQCRC2/ATP5F1C/COX5A/ATP5PO/PTPRJ/NDUFA4/NDUFB3/ATP5F1D/VDAC2/NDUFAB1/NDUFB11/UQCR10/VDAC3/SDHB/NDUFB4/ATP5F1E/NDUFB10/SLC25A6/NDUFS4/COX7B/UQCRFS1/MAPK8/COX5B/NDUFA2/NDUFS7/MAP2K1/COX6C/SOS1/NDUFS6/ATP5PF/PLD1/MAP2K4/PTEN/ATP5MC1/NDUFB7/NDUFS5/CBR1/CYBA/UQCRQ/CAT/NDUFB2/UQCR11/NDUFS8/NDUFB6/GSTO2/NDUFA9/ABL1/NDUFB9/HMOX1/SDHD/ATP5F1A/ACP1/NDUFC1/COX8A/MGST2/NDUFA12/PDPK1/GSTO1/SDHC/NDUFA10/ATP5F1B	9.20647458218837
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	104/1229	388/9376	2.04487765596034	COX7C/COX4I1/NDUFB1/ATP5MC2/COX6B1/UQCRH/NDUFB5/SLC25A5/COX7A2/ATP5PB/ATP5MC3/COX7A2L/UQCRB/PSMB1/UQCRC2/ATP5F1C/PTGS2/PSMA7/COX5A/ATP5PO/PLCB1/AMBRA1/PSMA4/NDUFA4/NDUFB3/SEM1/ATP5F1D/PSMA5/VDAC2/NDUFAB1/EIF2AK3/BID/NDUFB11/UQCR10/VDAC3/SDHB/NDUFB4/ATP5F1E/CTNNB1/MCU/NDUFB10/GAPDH/SLC25A6/SLC39A9/NDUFS4/NRBF2/COX7B/UQCRFS1/PSMA1/IL6/MAPK8/COX5B/PSMD12/NDUFA2/NDUFS7/MAP2K1/PPP3CC/COX6C/PSMD8/PSMD7/NDUFS6/ATP5PF/PSMB2/TUBA4A/PPP3CB/FRAT2/DKK1/PSMB7/ATP5MC1/NDUFB7/ATF6/HSD17B10/NDUFS5/PSMD13/ITPR1/WIPI1/ATP2A2/UQCRQ/EIF2S1/IRS2/NDUFB2/SLC39A11/PSMB6/ADAM10/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/ULK2/SDHD/GNAQ/ERN1/APH1A/GSK3B/ATP5F1A/NDUFC1/COX8A/TPTEP2-CSNK1E/NDUFA12/SDHC/NDUFA10/ATP5F1B/INSR	8.16417855830926
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	53/1229	157/9376	2.57538364264873	COX7C/COX4I1/NDUFB1/COX6B1/UQCRH/NDUFB5/COX7A2/COX7A2L/UQCRB/UQCRC2/COX5A/NDUFA4/NDUFB3/NDUFAB1/EIF2AK3/BID/NDUFB11/UQCR10/SDHB/NDUFB4/ADIPOR1/NDUFB10/NDUFS4/COX7B/UQCRFS1/IL6/MAPK8/COX5B/NDUFA2/NDUFS7/COX6C/NDUFS6/NDUFB7/NDUFS5/UQCRQ/EIF2S1/IRS2/NDUFB2/UQCR11/NDUFS8/NDUFB6/NDUFA9/NDUFB9/SDHD/ERN1/GSK3B/NDUFC1/COX8A/NDUFA12/SDHC/NDUFA10/INSR/BCL2L11	7.73137915480671
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1229	142/9376	2.36390515591515	RPS27A/UBA52/UBE2R2/UBE2S/COP1/ELOC/ELOB/PIAS1/UBE2E2/UBE2L6/UBE2E1/UBC/CDC26/UBE2D1/RNF7/UBE2B/RBX1/UBE2Q1/UBE2E3/UBB/WWP2/CUL1/MAP3K1/CUL3/BIRC6/CUL2/SIAH1/PRKN/UBE2K/ANAPC11/UBE4A/STUB1/CDC27/ANAPC16/CUL5/UBE2H/ERCC8/UBE2M/UBE2D2/UBE3A/HERC4/SAE1/CBLB/FBXW11	6.36057136468354
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	48/1229	174/9376	2.10454252125361	MARCHF6/HSPA5/ERP29/HERPUD1/TMEM258/SEC61G/SSR3/STT3B/UBE2D1/SEC24B/EIF2AK3/HSPA8/SEC62/SSR2/RBX1/OSTC/MAPK8/SSR4/CUL1/SSR1/PLAA/DNAJC3/SEC61B/LMAN1/SAR1B/SEC31A/PRKN/ATF6/SEC13/STUB1/CALR/ATXN3/DAD1/BAG1/RNF185/EIF2S1/SEC24A/MAGT1/DNAJC5/UBE2D2/DNAJC1/MAN1A2/MAN1C1/DERL2/ERN1/DERL1/PDIA6/FBXO6	5.71187468345775
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	46/1229	169/9376	2.07652346401799	RPS27A/UBA52/RAB7A/RAB1A/ATG3/IGBP1/ATG7/DAPK1/MAP1LC3B/TANK/UBC/C9orf72/AMBRA1/RPTOR/ATG5/EIF2AK3/GABARAPL2/NRBF2/UVRAG/CALCOCO2/VPS41/MAPK8/UBB/EPG5/BIRC6/MAP2K1/TAX1BP1/RRAGA/PTEN/RHEB/RAB8A/VAMP8/ITPR1/WIPI1/MTMR3/EIF2S1/MTMR14/IRS2/MAP1LC3B2/WDR45/ULK2/RRAGD/ERN1/PDPK1/ATG10/GABARAP	5.4849225869117
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	17/1229	42/9376	3.087915068387	FTH1/FTL/SAT2/ATG7/MAP1LC3B/ACSL5/VDAC2/ATG5/PCBP2/ACSL3/VDAC3/PRNP/SLC7A11/GCLC/MAP1LC3B2/HMOX1/PCBP1	5.26703612418987
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	38/1229	144/9376	2.01319952987976	SLC25A5/PSMB1/PSMA7/PRKCB/PLCB1/AMBRA1/PSMA4/ATXN10/SEM1/PSMA5/VDAC2/VDAC3/MCU/SLC25A6/NRBF2/PSMA1/ATXN1/MAPK8/PSMD12/PUM1/PSMD8/PSMD7/OPA1/PSMB2/PSMB7/ATXN3/PSMD13/ITPR1/PUM2/WIPI1/PRKCA/ATP2A2/PSMB6/ULK2/GNAQ/ATXN2/ERN1/GTF2B	4.75872983196659
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	30/1229	105/9376	2.17970475415553	RPS27A/UBA52/TOMM7/RAB7A/TOMM20/FOXO3/PHB2/ARIH1/MAP1LC3B/UBC/AMBRA1/TBC1D15/CITED2/EIF2AK3/GABARAPL2/FIS1/CALCOCO2/MAPK8/UBB/MON1B/MARCHF5/SIAH1/OPA1/TAX1BP1/PRKN/EIF2S1/MAP1LC3B2/RHOT1/MITF/GABARAP	4.7213631938224
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1229	31/9376	3.19924407464763	HSPA5/SEC11A/SPCS1/IMMP2L/SEC61G/SRP9/SEC62/OXA1L/SEC61B/SEC11C/SRP14/SRP72/SRP19	4.76351290465613
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/1229	46/9376	2.65355361375455	POMP/PSME4/PSMB1/PSMA7/PSMA4/SEM1/PSMA5/PSMB10/PSMA1/PSMD12/PSMD8/PSMD7/PSMB2/PSMB7/PSMD13/PSMB6	4.36635554031243
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/1229	78/9376	2.15175982140994	PABPC1/TENT4B/LSM6/PAN3/ZCCHC7/LSM5/MPHOSPH6/LSM8/TOB1/LSM7/XRN2/C1D/LSM3/CNOT6L/XRN1/EXOSC9/EXOSC1/CNOT7/NUDT16/LSM4/CNOT2/EXOSC7	3.96713679607004
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/1229	149/9376	1.74083802513092	NDUFB1/NDUFB5/ADCY3/PTGS2/PRKCB/PLCB1/NDUFA4/NDUFB3/NDUFAB1/NDUFB11/GNG5/NDUFB4/GNG7/NDUFB10/NDUFS4/GNG2/MAPK8/NDUFA2/NDUFS7/NDUFS6/NDUFB7/NDUFS5/ITPR1/PRKCA/NDUFB2/NDUFS8/NDUFB6/NDUFA9/NDUFB9/GNAQ/NDUFC1/NDUFA12/GNB1/NDUFA10	3.54037170159228
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/1229	248/9376	1.50733615055513	RPS3/RAB7A/ARPC3/EXOC4/SNX18/CASP4/MYL12A/ELMO1/BRK1/CASP1/LY96/DYNLL1/RIPK2/TAB2/PIK3CG/DYNLT1/TLR2/CTNNB1/GAPDH/TXN2/RHOB/VPS41/IL6/MAPK8/KPNA3/PAK1/DCTN3/TNFSF10/PYCARD/ACTG1/TCF7L2/MAP2K1/ACTR10/TUBA4A/DCTN6/MAP2K4/EXOC2/TXN/STX10/ABI1/WASL/NCKAP1L/MYL12B/CASP5/SNX9/DCTN2/ARPC2/M6PR/RAB9A	3.14482552326451
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	38/1229	187/9376	1.55027129573628	CARD16/ANTXR2/ERBIN/CASP4/STAT1/CASP1/MAP1LC3B/TANK/PLCB1/TXNIP/RIPK2/NAMPT/GBP5/VDAC2/ATG5/TRAF3/TAB2/VDAC3/GABARAPL2/MCU/TXN2/IL6/MAPK8/IFI16/GBP1/AIM2/PYCARD/NEK7/GBP3/CYBA/TXN/ITPR1/MAP1LC3B2/CASP5/GBP2/OAS1/DHX33/GABARAP	2.95206732582109
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	21/1229	87/9376	1.84147470609691	COX7C/COX4I1/COX6B1/UQCRH/COX7A2/COX7A2L/UQCRB/UQCRC2/COX5A/UQCR10/COX7B/UQCRFS1/COX5B/CACNA2D3/COX6C/SLC9A7/ATP2A2/UQCRQ/UQCR11/ATP1B1/COX8A	3.06251999173594
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/1229	21/9376	2.9062730055407	VNN1/PPCDC/VNN2/BCAT1/UPB1/PANK2/PPCS/AASDHPPT	3.39653090722592
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/1229	250/9376	1.46476159479251	CTSS/AP1S2/RAB7A/SLC17A5/CTSH/ATP6V1G1/NPC1/LAMTOR4/CTBS/SUMF1/DTNBP1/WDR7/GNS/NPC2/RPTOR/LAMTOR1/LAMTOR5/VPS35/ATP6V0E1/LITAF/VPS29/CLTA/VPS41/AP2S1/GPR155/ARSG/BORCS7/ATP6V1D/RRAGA/SPG11/ROGDI/FIG4/ASAH1/VAMP8/LAPTM4A/SNAPIN/ARSB/AP3S1/LAMTOR2/LAMTOR3/RRAGD/KXD1/ATP6V0C/CTSW/TLR7/MITF/AP1G1/M6PR	2.89282876261047
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/1229	32/9376	2.38405207485761	ATG3/IGBP1/ATG7/RPTOR/ATG5/GABARAPL2/WIPI1/ULK2/ATG10/GABARAP	3.04595670833121
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	25/1229	116/9376	1.64417384472938	PGLS/HK2/TKT/PCCA/MDH2/ESD/SUCLG2/SDHB/GAPDH/IDH3G/TALDO1/SUCLG1/TPI1/ACO2/ACAT2/ME2/CAT/PGD/SDSL/SDHD/PGAM1/IDH3A/FBP1/RPIA/SDHC	2.71137326855425
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1229	33/9376	2.3118080725892	STX8/VAMP5/VTI1A/STX18/USE1/VAMP8/STX11/STX5/VAMP3/VAMP4	2.93188422066736
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	47/1229	253/9376	1.41723886189164	RPS27A/H3-3B/UBA52/H3-3A/FOXO3/MALT1/ARPC3/U2AF1/PRKCE/CASP4/MYL12A/ELMO1/CASP1/MAP1LC3B/HK2/UBC/PLCB1/UBE2D1/RIPK2/RPTOR/ATG5/TAB2/HCLS1/RBX1/SEPTIN9/CALCOCO2/MAPK8/UBB/CUL1/PYCARD/ACTG1/UBE2V2/FNBP1/RRAGA/RPS6KA5/ITPR1/WIPI1/WASL/UBE2D2/MYL12B/MAP1LC3B2/RRAGD/GSK3B/ARPC2/FOXO1/FBXW11/ATM	2.61299691356468
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/1229	30/9376	2.2886899918633	MDH2/SUCLG2/SDHB/IDH3G/SUCLG1/ACO2/SDHD/IDH3A/SDHC	2.74573687471994
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	31/1229	158/9376	1.49682256851819	RPS6/ATP6V1G1/FNIP2/LAMTOR4/PRKCB/LPIN2/RPTOR/LAMTOR1/LAMTOR5/EIF4EBP1/MAP2K1/SOS1/EIF4B/ATP6V1D/RRAGA/PTEN/RHEB/SEC13/PRKCA/LAMTOR2/LAMTOR3/SEH1L/ULK2/RRAGD/GSK3B/MIOS/PDPK1/RPS6KA2/LPIN1/TBC1D7/INSR	2.44610011935996
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/1229	69/9376	1.76903574250304	GAB2/RAC2/LYN/PLA2G4C/MAPK8/FYN/MAP2K1/SOS1/MAP2K4/PRKCA/BTK/PLA2G4A/PDPK1/FCER1A/LCP2/VAV1	2.49016964553773
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1229	214/9376	1.39032569599173	AP1S2/APOBEC3A/ELOC/ELOB/RAC2/PRKCB/CD4/APOBEC3G/RNF7/BID/TAB2/GNG5/TLR2/GNG7/RBX1/GNG2/MAPK8/PAK1/CUL1/NFATC3/MAP2K1/PPP3CC/PPP3CB/APOBEC3F/CFL1/CALR/APOBEC3B/APOBEC3C/ATR/ITPR1/PRKCA/CUL5/GNAQ/DCAF1/TRIM5/AP1G1/GNB1/FBXW11/ATM	2.24337361251648
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	36/1229	196/9376	1.40123877052855	RPS27A/UBA52/CLEC2B/ATG3/CD86/STAT1/MAP1LC3B/UBC/PTGS2/JAK2/PIK3R5/LYN/TRAF3/BID/PIK3CG/GNG5/GNG7/CTNNB1/GNG2/IL6/MAPK8/UBB/CREB1/NFATC3/TCF7L2/MAP2K1/PPP3CC/PPP3CB/MAP2K4/ITPR1/ZFP36/MAP1LC3B2/IFNGR1/IL6ST/GSK3B/GNB1	2.20481577510628
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1229	78/9376	1.66272349836223	HLA-DQA2/EEF1A1/HLA-DRB5/FCGR2C/NCF2/STAT1/PTGS2/PRKCB/JAK2/ITGA4/TAB2/TLR2/CYBA/NCF4/FCGR3B/IFNGR1/CR1	2.28269360252087
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	29/1229	154/9376	1.43662358796614	CAMK2D/MEF2C/CAMK1D/ADCY3/PTGS2/CAMK1/PPP1CC/PRKCB/PLCB1/PIK3R5/MAP2K5/MYL6/PIK3CG/PLA2G4C/NFATC3/ACTG1/MAP2K1/PPP3CC/CACNA2D3/PPP1R12B/PPP3CB/PPP1CA/ITPR1/PRKCA/GNAQ/PLA2G4A/CD38/EEF2/PPP1R12A	2.12186484318433
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/1229	195/9376	1.3693017045336	H3-3B/H3-3A/MACROH2A1/H2AZ1/H2AZ2/NCF2/H2AC20/SLC25A5/H2AJ/CASP4/RAC2/ATG7/CASP1/PRKCB/PLCB1/VDAC2/VDAC3/TLR2/HDAC9/SLC25A6/AQP9/FPR1/FPR2/ACTG1/MAP2K1/H4C3/CLCN5/CYBA/PRKCA/NCF4/FCGR3B/HDAC4/TLR7/CR1/HAT1	2.02402720532806
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	43/1229	250/9376	1.31218226200163	RAB7A/ARPC3/RAB11A/ASAP1/IQSEC1/ARF5/VPS35/HSPA8/VPS29/SNF8/CLTA/RAB4A/CHMP5/AP2S1/SMAP2/TSG101/WASHC3/SMAD2/SNX2/GRK5/ACAP2/GBF1/ARFGEF2/PLD1/STAM/ARF4/RAB8A/RAB10/RAB31/CHMP2B/CAPZA2/WIPF1/SMAP1/WASL/PSD/EPS15/PIP5K1B/GIT2/ARRB1/SH3KBP1/CBLB/ARPC2/MVB12A	1.94312489847246
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/1229	83/9376	1.56255943219583	PCGF5/SCML1/SFMBT2/UBE2D1/MBD5/L3MBTL4/YAF2/ASXL2/JARID2/PHF19/FOXK2/CBX4/MAX/UBE2D2/OGT/RNF2/TFDP1	1.99936557336322
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	21/1229	108/9376	1.4834101799114	EEF1A1/SUMO2/NUP214/EIF4A3/SAP18/THOC7/KPNA3/ALYREF/NXT1/XPO4/SUMO1/MAGOH/SUMO3/XPO6/SEC13/NXF1/SEH1L/KPNA2/NUP210L/TMEM33/NUP37	1.96244447813778
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	8/1229	31/9376	1.96876558439854	RBKS/PGLS/TKT/DERA/TALDO1/PGD/FBP1/RPIA	2.09832433610561
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1229	31/9376	1.96876558439854	PCCA/GRHPR/MDH2/GLUL/AFMID/ACO2/ACAT2/CAT	2.09832433610561
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/1229	78/9376	1.56491623375269	INPP5A/IPMK/PLCB1/PIK3CG/SYNJ1/MTM1/TPI1/PIP4K2A/PTEN/INPP4A/ITPKB/FIG4/PPIP5K2/MTMR3/MTMR14/PIP5K1B	1.94580496381104
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1229	110/9376	1.45643908573119	RPS6/CAMK2D/ELOC/ELOB/PFKFB3/HK2/PRKCB/RBX1/GAPDH/IL6/CDKN1B/EIF4EBP1/LDHB/MAP2K1/CUL2/PRKCA/IFNGR1/HMOX1/MKNK2/EDN1/INSR	1.8702331168136
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1229	67/9376	1.59411243214359	CAMK2D/RAP1A/PPP1CC/PRKCB/PLCB1/MAP2K1/PPP3CC/PPP3CB/PPP1CA/ITPR1/PRKCA/GNAQ/RAP1B/RPS6KA2	1.89547145281426
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1229	98/9376	1.47908536889125	GAB2/ARPC3/PRKCE/RAC2/PLA2G6/ASAP1/PRKCB/LYN/PLA2G4C/PAK1/MAP2K1/PLD1/CFL1/PRKCA/FCGR3B/PIP5K1B/PLA2G4A/ARPC2/VAV1	1.85166101540138
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	37/1229	216/9376	1.30681372992195	HSPA5/CAMK2D/NCF2/CCL3L1/RAP1A/CASP1/TANK/LY96/PLCB1/JAK2/LYN/EIF2AK3/TRAF3/BID/TAB2/HSPA8/TLR2/IL6/MAPK8/TNFSF10/NFATC3/PYCARD/PPP3CC/PPP3CB/MAP2K4/ATF6/CYBA/ITPR1/PRKCA/NCF4/EIF2S1/MMP1/ERN1/GSK3B/RAP1B/PDPK1/VAV1	1.77180796885857
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/1229	125/9376	1.40372986167616	GAB2/PRKCE/SGMS1/RAC2/PRKCB/PLCB1/CERS6/BID/MAPK8/FYN/MAP2K1/PPP2R5C/PLD1/PTEN/PPP2R5E/ASAH1/NSMAF/PRKCA/GNAQ/S1PR4/PDPK1/FCER1A/CERS4	1.76487625672249
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1229	126/9376	1.39258914848825	TBXAS1/RAP1A/MYL12A/ADCY3/PPP1CC/PLCB1/PIK3R5/LYN/PIK3CG/PLA2G4C/FYN/ACTG1/PPP1CA/VAMP8/ITPR1/BTK/STIM1/MYL12B/GNAQ/PLA2G4A/RAP1B/LCP2/PPP1R12A	1.72311958565716
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1229	63/9376	1.57423121133455	ERCC1/POLE4/POLR2L/RPA2/RBX1/CCNH/POLR2I/RPA3/POLR2G/POLR2F/ERCC8/GTF2H5/RFC1	1.77613097745443
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1229	28/9376	1.90724165988609	GPHN/GCH1/PTS/CBR1/AKR1B1/PCBD1/PCBD2	1.86726247584545
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	29/1229	168/9376	1.31690495563563	FTH1/MACROH2A1/H2AZ1/FTL/H2AZ2/CAMK2D/H2AC20/SLC25A5/H2AJ/STAT1/CASP1/JAK2/VDAC2/BID/GLUL/VDAC3/SLC25A6/PLA2G4C/CHMP5/MAPK8/PYGL/TNFSF10/PYCARD/STAT4/CHMP2B/ZBP1/IFNGR1/PLA2G4A/PARP1	1.60976965928389
Genetic Information Processing	Transcription	hsa03040	Spliceosome	40/1229	243/9376	1.25579697770277	U2AF1/LSM6/SF3B5/SNRPB2/LSM5/CTNNBL1/EIF4A3/SRSF9/SNRPE/HSPA8/SF3B6/TXNL4A/SNRPD2/SNRPG/LSM8/SLU7/THOC7/LSM7/BUD31/LSM3/ALYREF/SNRNP40/PQBP1/SNU13/SNRPD1/CDC40/SNRPF/HNRNPC/MAGOH/PPIE/HNRNPA1/WBP11/PPIH/BCAS2/SNRPC/ZMAT2/CWC15/LSM4/PHF5A/PCBP1	1.56911414832825
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1229	59/9376	1.55165423177173	GPX1/GSTK1/GSTP1/GCLC/SMS/PGD/GSTO2/LAP3/ODC1/MGST2/GSTO1/PRDX6	1.65088808687584
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	17/1229	91/9376	1.42519157002477	MALT1/RAC2/PRKCB/IFITM1/LYN/DAPP1/LILRA5/NFATC3/CD79B/MAP2K1/PIK3AP1/PPP3CC/SOS1/PPP3CB/BTK/GSK3B/VAV1	1.58298612806757
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1229	85/9376	1.43604077920835	ADSS2/ADK/CDA/NT5C2/DGUOK/CMPK1/ADA2/DUT/ITPA/APRT/ENTPD1/ASMTL/NUDT16/DCK/HDDC2/HPRT1	1.56844054809181
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1229	98/9376	1.40123877052855	INPP5A/IPMK/PRKCB/PLCB1/SYNJ1/BPNT2/MTM1/PIP4K2A/PTEN/INPP4A/ITPKB/ITPR1/PRKCA/PPIP5K2/MTMR3/MTMR14/PIP5K1B/PIP4P2	1.55078455218688
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1229	138/9376	1.32677680687728	RPS6/INPP5A/HK2/PPP1CC/RPTOR/MAPK8/PYGL/EIF4EBP1/MAP2K1/SOS1/RHEB/PRKAR2A/PPP1CA/IRS2/RAPGEF1/PRKAR1A/CBLB/MKNK2/GSK3B/PDE3B/FOXO1/PDPK1/FBP1/INSR	1.50198124747555
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/1229	138/9376	1.32677680687728	ARPC3/RAC2/ELMO1/CASP1/CD4/ITGA4/TAB2/IL6/MAPK8/NFATC3/PYCARD/ACTG1/MAP2K1/MAP2K4/WIPF1/WASL/PIP5K1B/GIT2/GNAQ/GSK3B/ARPC2/RPS6KA2/LCP2/VAV1	1.50198124747555
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1229	30/9376	1.78009221589368	PIGA/PIGX/PIGF/PIGP/PIGK/PIGC/PIGN	1.66209715011775
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1229	42/9376	1.63477856561665	KMO/KYAT3/HADHA/AFMID/ACAT2/IDO1/CAT/ALDH9A1/IDO2	1.60131112926314
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/1229	93/9376	1.39454228894897	RAP1A/RAC2/MYL12A/PTPRJ/FER/NLK/CTNNB1/FARP2/FYN/ACTG1/TCF7L2/PDCD10/WASL/MYL12B/ACP1/RAP1B/INSR	1.48509275829792
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/1229	133/9376	1.31929498277835	FOXO3/HOMER1/GABARAPL2/NLK/IL6/MAPK8/CDKN1B/TNFSF10/MAP2K1/SOS1/PTEN/C8orf44-SGK3/CAT/CDKN2D/IRS2/FOXO1/TPTEP2-CSNK1E/S1PR4/PDPK1/GABARAP/ATM/INSR/BCL2L11	1.44037030668733
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	23/1229	133/9376	1.31929498277835	CD48/HCST/TYROBP/RAC2/ICAM2/PRKCB/BID/FYN/PAK1/TNFSF10/MAP2K1/PPP3CC/SOS1/CD244/PPP3CB/PRKCA/ULBP2/LAT2/KLRD1/FCGR3B/IFNGR1/LCP2/VAV1	1.44037030668733
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	11/1229	56/9376	1.49854701848192	TMEM258/STT3B/DHRSX/OSTC/DPM1/ST6GAL1/ALG5/DAD1/MAGT1/MAN1A2/MAN1C1	1.45329875716788
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1229	128/9376	1.31122864117168	ADSS2/ADK/ADCY3/PDE8A/FHIT/NUDT2/NT5C2/DGUOK/PAPSS2/PDE2A/ADA2/PDE4D/ITPA/APRT/ENTPD1/PDE7B/NUDT16/DCK/PDE1B/PDE3B/HDDC2/HPRT1	1.37696642984428
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/1229	142/9376	1.28940281231735	FCGR2C/GAB2/TYROBP/NCF2/STAT1/TAB2/LILRA5/MAPK8/FYN/CREB1/MAP2K1/PPP3CC/PPP3CB/CYBA/ITPR1/NCF4/ATP2A2/RELB/BTK/SIRPB1/FCGR3B/IFNGR1/MITF/LCP2	1.34962994523584
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1229	44/9376	1.56047044899771	GTF2A2/TAF12/CCNH/GTF2A1/GTF2F2/GTF2H5/TAF4B/GTF2B/TAF3	1.44728617594998
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	26/1229	157/9376	1.2633957492239	RAB7A/CAMK2D/CX3CR1/ELMO1/CASP1/PTGS2/PLA2G6/JAK2/THBS1/CD47/UQCRFS1/VPS8/VPS41/CREB1/ATP11B/NFATC3/DUSP5/MAP2K1/CALR/SIGLEC10/ATP2A2/SIRPB1/ADAM10/ATP11C/ATP8A1/ODC1	1.29264539118264
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	26/1229	157/9376	1.2633957492239	FOXO3/SLC25A5/PPP1CC/VDAC2/ZFP36L2/VDAC3/MCU/SLC25A6/IL6/EIF4EBP1/NFATC3/MAP2K1/SMAD2/PPP3CC/HIPK2/PPP3CB/CCND3/PTEN/RHEB/PPP1CA/ATR/ITPR1/ZFP36L1/FOXO1/FBXW11/ATM	1.29264539118264
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1229	51/9376	1.49587581167536	ATP6V1G1/ADCY3/SEC61G/KCNQ1/ATP6V0E1/SEC61B/ACTG1/ATP6V1D/PRKCA/ATP6V0C	1.3791017629885
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/1229	104/9376	1.32039807222883	GPAT3/SGMS1/PLA2G6/LPIN2/LYPLA1/CHKA/GPD2/PLA2G4C/TAFAZZIN/CHPT1/PTDSS1/PLD1/CEPT1/GDPD5/PISD/PLA2G4A/PGS1/LPIN1	1.27609372770332
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1229	10/9376	2.2886899918633	PAPSS2/BPNT2/MPST	1.58355845896804
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1229	91/9376	1.34135677178802	ADCY3/PRKCB/PDE8A/GNG5/GNG7/GNG2/PDE2A/GRK5/PDE4D/OPRM1/PRKCA/PDE7B/PDE1B/ARRB1/PDE3B/GNB1	1.27086958575139
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	27/1229	166/9376	1.24085601968492	PRKCE/SLC25A5/MEF2C/ADCY3/PPP1CC/PLCB1/PIK3R5/VDAC2/PIK3CG/VDAC3/SLC25A6/PDE2A/CREB1/NFATC3/MAP2K1/PPP3CC/PPP3CB/PPP1CA/ITPR1/ATP2A2/ATF2/IRS2/ATP1B1/GNAQ/PDE3B/INSR/PPP1R12A	1.21603046524336
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1229	133/9376	1.2619343313532	CAMK2D/PPP1CC/PRKCB/PLCB1/GNG5/GNG7/GNG2/MAPK8/CREB1/PPP2R5C/PPP3CC/PPP3CB/PPP2R5E/PPP1CA/ITPR1/PRKCA/ATF2/ARRB1/GNAQ/GSK3B/GNAL/GNB1	1.18161090381135
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1229	34/9376	1.57066960225913	NR1D2/CRY1/RBX1/CUL1/CREB1/TPTEP2-CSNK1E/FBXW11	1.29469356137642
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1229	86/9376	1.3306337161996	NRG1/CAMK2D/PRKCB/MAPK8/PAK1/CDKN1B/EIF4EBP1/MAP2K1/SOS1/MAP2K4/PRKCA/GAB1/ABL1/CBLB/GSK3B	1.19633064739083
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/1229	224/9376	1.1920260374288	HLA-DQA2/HLA-DRB5/SLC25A5/IL15/ADCY3/CD4/CDC26/VDAC2/VDAC3/TSPO/SLC25A6/RANBP1/IL6/MAPK8/MAP3K1/CREB1/NFATC3/MAP2K1/SMAD2/PPP3CC/PPP3CB/CCND3/MAP2K4/ANAPC11/PTEN/CALR/CDC27/ATR/ANAPC16/RELB/ZFP36/ATF2/POLB/DLG1/ATM	1.12976689589353
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1229	80/9376	1.33506916192026	NRG1/RPS6/FOXO3/PRKCB/JAK2/IL6/EIF4EBP1/MAP2K1/SOS1/PTEN/PRKCA/GAB1/GSK3B/BCL2L11	1.16894510548826
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1229	54/9376	1.41277159991562	MDH2/KYAT3/LDHB/BCAT1/GCLC/SMS/AHCYL2/MPST/MAT2B/SDSL	1.18144867838802
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1229	48/9376	1.43043124491456	PCCA/HADHA/BCAT1/HSD17B10/ACAT2/ALDH9A1/IVD/ACADM/AUH	1.16116212265667
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1229	122/9376	1.25065026877776	STAT1/PRKCB/PLCB1/MED30/NCOA2/CTNNB1/NCOA1/MED27/ACTG1/MAP2K1/RHEB/NCOA3/NOTCH2/PRKCA/ATP2A2/SLC16A10/ATP1B1/GSK3B/FOXO1/PDPK1	1.08229602624652
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1229	17/9376	1.79505097401043	MARS1/PAPSS2/KYAT3/SEPHS2	1.27428752801444
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1229	23/9376	1.6584710085966	PDSS2/PMVK/ACAT2/FNTA/NUS1	1.2279702089248
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	17/1229	102/9376	1.27149443992406	RAP1A/RAB11A/ADCY3/PRKCB/PLCB1/KCNQ1/BST1/RAB8A/ITPR1/PRKCA/ATP2A2/CA2/CELA2B/ATP1B1/GNAQ/RAP1B/CD38	1.07075522289692
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	13/1229	75/9376	1.32235421752102	TKT/GLUL/GAPDH/IDH3G/TALDO1/TPI1/BCAT1/ACO2/MAT2B/SDSL/PGAM1/IDH3A/RPIA	1.08858385186531
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/1229	109/9376	1.25982935331925	PRKCE/PPP1CC/PRKCB/IL6/MAPK8/PYGL/CREB1/PTEN/PPP1CA/IRS2/OGA/OGT/GSK3B/FOXO1/PDPK1/RPS6KA2/TRIB3/INSR	1.05972846851757
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	19/1229	116/9376	1.24957212199433	HOMER1/ADCY3/PRKCB/PLCB1/GNG5/GLUL/GNG7/PLA2G4C/DLGAP1/GNG2/PPP3CC/PPP3CB/PLD1/ITPR1/PRKCA/SLC38A1/GNAQ/PLA2G4A/GNB1	1.05046671125877
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/1229	193/9376	1.18584973671674	FOXO3/CCL3L1/CX3CR1/RAP1A/RAC2/ELMO1/STAT1/ADCY3/PRKCB/PLCB1/CCL4L2/JAK2/PIK3R5/CXCL14/LYN/PIK3CG/GNG5/GNG7/GNG2/PAK1/MAP2K1/GRK5/SOS1/ARRB1/GNAQ/GSK3B/RAP1B/TIAM1/GNB1/VAV1	1.01323698517374
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/1229	173/9376	1.19064797264565	HLA-DQA2/HLA-DRB5/SLC25A5/STAT1/RAB11A/CASP1/PRKCB/JAK2/TRAF3/BID/SLC25A6/CALCOCO2/IL6/NXT1/TNFSF10/DNAJC3/PYCARD/ACTG1/MAP2K1/CCND3/PRKCA/NXF1/EIF2S1/IFNGR1/OAS1/KPNA2/TLR7	0.982999401421429
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1229	138/9376	1.21621207297084	CAMK2D/ADCY3/PPP1CC/CDC26/RBX1/CUL1/MAP2K1/PPP2R5C/PPP3CC/PPP3CB/CPEB4/ANAPC11/PPP2R5E/CDC27/PPP1CA/ANAPC16/ITPR1/YWHAB/CPEB3/YWHAQ/RPS6KA2/FBXW11	0.993786805689592
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1229	90/9376	1.27149443992406	FOXO3/ADCY3/RPTOR/ATG5/ADIPOR1/CREB1/EIF4EBP1/RHEB/APPL1/CAT/ATF2/IRS2/FOXO1/SESN3/INSR	1.00514930433404
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1229	70/9376	1.30782285249332	ELOC/ELOB/RAP1A/RBX1/PAK1/MAP2K1/CUL2/SOS1/GAB1/RAPGEF1/PRCC/RAP1B	1.0039939036142
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1229	37/9376	1.44331801288677	PRKCB/PLCB1/IL6/PRKCA/IDO1/GNAQ/IDO2	1.0493703130135
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1229	99/9376	1.2329643053809	RAC2/PRKCB/LYPLA1/CHKA/PLA2G4C/MAPK8/EIF4EBP1/MAP2K1/CHPT1/SOS1/PLD1/RHEB/PRKCA/PIP5K1B/PLA2G4A/PDPK1	0.905036145179815
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/1229	120/9376	1.20791971792785	FOXO3/CAMK2D/RAP1A/RIPK2/MAP2K5/MAPK8/MAP3K1/ARHGDIB/MAP2K1/SOS1/RPS6KA5/FRS2/GAB1/RAPGEF1/ABL1/GSK3B/RAP1B/PDPK1/RPS6KA2	0.890301999719401
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1229	93/9376	1.23047849024909	CAMK2D/ADCY3/PRKCB/PLCB1/PLA2G4C/MAPK8/MAP3K1/MAP2K1/SOS1/PLD1/MAP2K4/ITPR1/PRKCA/GNAQ/PLA2G4A	0.867541823524606
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1229	52/9376	1.32039807222883	NPC1/NPC2/VDAC2/VAPA/VDAC3/TSPO/SOAT1/STARD3NL/LIPC	0.899814847960724
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1229	32/9376	1.43043124491456	PCCA/SUCLG2/SUCLG1/HADHA/LDHB/ECHDC1	0.947272838746155
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1229	59/9376	1.29304519314311	CDA/NUDT2/NT5C2/CMPK1/DUT/UPB1/ENTPD1/ASMTL/DCK/HDDC2	0.876971099673124
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1229	115/9376	1.19409912618955	CAMK2D/ADCY3/PRKCB/PLCB1/JAK2/PIK3R5/PIK3CG/GNG5/KCNQ1/GNG7/GNG2/FYN/CREB1/MAP2K1/ITPR1/PRKCA/GNAQ/GNB1	0.813403955149356
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/1229	137/9376	1.1694036454776	CTSS/CTSH/PMAIP1/EIF2AK3/BID/MAPK8/TNFSF10/IL3RA/ACTG1/MAP2K1/TUBA4A/BCL2A1/ITPR1/EIF2S1/PARP4/ERN1/CTSW/PDPK1/PARP1/ATM/BCL2L11	0.775770522522216
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/1229	203/9376	1.12743349352872	RAP1A/RAC2/MYL12A/PPP1CC/PRKCB/THBS1/ITGA4/CTNNB1/MAPK8/FYN/PAK1/ACTG1/MAP2K1/SOS1/PPP1R12B/CCND3/PTEN/PPP1CA/PRKCA/PARVB/PIP5K1B/MYL12B/RAPGEF1/GSK3B/RAP1B/PDPK1/VAV1/ITGB8/COL6A2/PPP1R12A	0.712916445234754
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1229	75/9376	1.2206346623271	GPX1/HSPA5/TG/ADCY3/PRKCB/PLCB1/CREB1/ITPR1/PRKCA/ATF2/ATP1B1/GNAQ	0.745078914797723
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1229	34/9376	1.34628823050783	POLR1F/POLR2L/POLR1D/POLR2I/POLR2G/POLR2F	0.785633474507959
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1229	41/9376	1.3025064994344	BABAM2/RAD51B/SEM1/RPA2/RPA3/ATM/RAD52	0.753932037787291
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1229	76/9376	1.20457367992805	CAMK2D/ADCY3/PRKCB/PLCB1/KCNQ1/ACTG1/ITPR1/PRKCA/CA2/ATP1B1/GNAQ/KCNJ15	0.695469039043055
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1229	21/9376	1.45313650277035	UST/CHST11/CHST7/CHST15	0.807382852497147
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/1229	155/9376	1.13204021102916	HLA-DQA2/CTSS/HLA-DRB5/RAB7A/FCGR2C/NCF2/ATP6V1G1/SEC61G/THBS1/TLR2/ATP6V0E1/SEC61B/ACTG1/STX18/TUBA4A/ATP6V1D/CALR/CYBA/NCF4/FCGR3B/VAMP3/ATP6V0C/M6PR	0.643792287050208
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1229	28/9376	1.3623154713472	ATP6V1G1/ATP6V0E1/ATP6V1D/CA2/ATP6V0C	0.745708794005159
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1229	178/9376	1.1143434417312	CAMK2D/RAC2/PRKCB/PLCB1/NLK/RBX1/CTNNB1/INVS/MAPK8/CUL1/NFATC3/TBL1XR1/TCF7L2/PPP3CC/TBL1X/SIAH1/PPP3CB/FRAT2/CCND3/DKK1/CTBP2/PRKCA/CCDC88C/GSK3B/TPTEP2-CSNK1E/FBXW11	0.598187426674094
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1229	35/9376	1.30782285249332	PFKFB3/GMDS/HK2/TPI1/AKR1B1/FBP1	0.708599621388289
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1229	56/9376	1.22608392421248	EEF1A1/RAB1A/CASP1/HSPA8/TLR2/IL6/PYCARD/SAR1B/CR1	0.659050147514927
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/1229	142/9376	1.12822746077768	SUMO2/NCF2/MEF2C/GSTP1/RAC2/MAP2K5/CTNNB1/TXN2/MAPK8/ACTG1/SUMO1/SUMO3/MAP2K4/CYBA/TXN/ACVR2A/GSTO2/HMOX1/MGST2/GSTO1/EDN1	0.597988732318689
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/1229	99/9376	1.1559040362946	CAMK2D/PRKCE/PRKCH/ADCY3/PLA2G6/PPP1CC/PRKCB/PLCB1/PLA2G4C/MAPK8/PPP1CA/ITPR1/PRKCA/GNAQ/PLA2G4A	0.605666983168668
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1229	78/9376	1.17368717531451	ARPC3/ELMO1/HCLS1/CTNNB1/SEPTIN9/CLTA/ACTG1/WASL/GAB1/CD2AP/ARPC2/SEPTIN1	0.598250408971707
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1229	107/9376	1.14078005824962	CAMK2D/PLCB1/SIK1/PYGL/CREB1/LDHB/PPP3CC/PPP3CB/ITPR1/ATF2/GNAQ/PGAM1/PDE3B/SIK2/FOXO1/FBP1	0.568825830815151
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1229	36/9376	1.27149443992406	ST6GALNAC3/GALNT1/C1GALT1/ST6GALNAC2/GALNT3/B4GALT5	0.633871862080347
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/1229	93/9376	1.14844659089915	HLA-DQA2/HLA-DRB5/STAT1/JAK2/CD4/MAML3/MAPK8/NFATC3/PPP3CC/PPP3CB/STAT4/NOTCH2/IFNGR1/IL12RB1	0.558766356137949
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	18/1229	122/9376	1.12558524189999	FOXO3/PFKFB3/RAB2A/RPTOR/ADIPOR1/CREB1/EIF4EBP1/PPP2R5C/RHEB/RAB8A/RAB10/PPP2R5E/IRS2/FOXO1/PDPK1/FBP1/INSR/EEF2	0.542271145075355
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/1229	122/9376	1.12558524189999	MALT1/CD4/MAPK8/FYN/PAK1/NFATC3/MAP2K1/PPP2R5C/PPP3CC/SOS1/PPP3CB/PPP2R5E/DLG1/CBLB/GSK3B/PDPK1/LCP2/VAV1	0.542271145075355
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1229	51/9376	1.19670064934029	PLA2G6/PEDS1/PLA2G4C/CHPT1/PLA2G7/PLD1/CEPT1/PLA2G4A	0.547052721466015
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1229	44/9376	1.21369923810933	TMEM258/STT3B/OSTC/DAD1/MAGT1/MAN1A2/MAN1C1	0.551829188639235
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1229	44/9376	1.21369923810933	RAB11A/ADCY3/DYNLL1/ARHGDIB/CREB1/DCTN6/DCTN2	0.551829188639235
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1229	37/9376	1.23712972533152	GMDS/HK2/NANS/GALK2/CMAS/PGM3	0.561305624546086
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1229	73/9376	1.14957031554778	APOBEC3A/CD4/APOBEC3G/TSG101/APOBEC3F/PIN1/MDFIC/APOBEC3B/APOBEC3C/SERINC5/TRIM5	0.498262325867278
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1229	140/9376	1.08985237707776	RPS6/PRKCE/MEF2C/ADCY3/MAP1LC3B/PLCB1/PIK3R5/PIK3CG/GNG5/GNG7/GNG2/NRF1/MAP2K1/SMAD2/ITPR1/HDAC4/MAP1LC3B2/GNAQ/PDE3B/GNB1	0.416020132724542
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/1229	89/9376	1.1143434417312	ADCY3/PRKCB/GPHN/GNG5/GLUL/GABARAPL2/GNG7/GNG2/PLCL1/PRKCA/SLC38A1/GNB1/GABARAP	0.420950725497117
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1229	60/9376	1.14434499593165	RAC2/PTGS2/PRKCB/PLA2G4C/MAP2K1/PPP3CC/PPP3CB/PRKCA/PLA2G4A	0.435637582527095
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1229	60/9376	1.14434499593165	PRKCB/PLCB1/LYN/PLA2G4C/MAP2K1/ITPR1/PRKCA/GNAQ/PLA2G4A	0.435637582527095
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1229	17/9376	1.34628823050783	CA5B/GLUL/CA2	0.555021989355515
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1229	53/9376	1.15154213427084	RAB11A/PRKCB/PLCB1/CLTA/AP2S1/PRKCA/ATP1B1/GNAQ	0.429690956704433
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/1229	75/9376	1.11891510713317	COP1/PMAIP1/THBS1/BID/SIAH1/CCND3/PTEN/ATR/SIVA1/SESN3/ATM	0.401573977730139
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/1229	105/9376	1.08985237707776	MALT1/STAT1/CASP1/PTGS2/IL6/MAPK8/PAK1/NFATC3/PYCARD/PPP3CC/PPP3CB/KSR1/ITPR1/RELB/CBLB	0.35960328592223
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1229	83/9376	1.10298312860882	GSTK1/ACSL5/ACSL3/PEX2/NUDT7/PMVK/SCP2/CAT/HACL1/PEX16/MPV17/PEX14	0.366007412184031
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/1229	232/9376	1.05227126062681	CYRIB/CYRIA/TMSB4X/ARPC3/RAC2/MYL12A/BRK1/PPP1CC/ITGA4/C7/PAK1/RDX/ITGAE/ACTG1/MAP2K1/SOS1/LPAR1/PIP4K2A/PPP1R12B/SSH2/CFL1/ARHGEF6/PPP1CA/WASL/NCKAP1L/PIP5K1B/MYL12B/ARPC2/TIAM1/VAV1/ITGB8/PPP1R12A	0.313113346122369
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/1229	98/9376	1.08985237707776	CAMK2D/PRKCE/CAMK1D/ADCY3/CAMK1/PRKCB/PLCB1/PDE2A/CREB1/ITPR1/PRKCA/ATF2/ATP1B1/GNAQ	0.347278699328858
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1229	32/9376	1.1920260374288	PMAIP1/BID/MAPK8/BIRC6/BCL2L11	0.422601871349892
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1229	47/9376	1.13622907397469	GRHPR/MDH2/ACYP2/LDHB/ACAT2/ME2/ALDH9A1	0.3636335186871
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/1229	62/9376	1.10743064122418	FOXO3/ADCY3/RPTOR/ATG5/HSPA8/CAT/IRS2/FOXO1/INSR	0.32962384221014
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/1229	204/9376	1.04711306817275	RPS6/LUM/CAMK2D/DCN/PPP1CC/PRKCB/THBS1/TLR2/HCLS1/CTNNB1/PAK1/RDX/ACTG1/MAP2K1/SMAD2/SOS1/EIF4B/PPP1R12B/PDCD4/FRS2/PPP1CA/ITPR1/PRKCA/GAB1/TIAM1/PDPK1/VAV1/PPP1R12A	0.264233069692255
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/1229	122/9376	1.0630527284611	STAT1/ADCY3/PRKCB/PLCB1/JAK2/MAPK8/MAP3K1/CREB1/MAP2K1/SOS1/MAP2K4/ITPR1/PRKCA/ATF2/IRS2/GNAQ/GSK3B	0.272258704489772
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1229	56/9376	1.08985237707776	CUL1/CUL3/ARRB1/GSK3B/TPTEP2-CSNK1E/SPOP/FBXW11/SCUBE2	0.261925842688452
NA	NA	hsa04517	IgSF CAM signaling	40/1229	299/9376	1.02059754375175	CD48/ARPC3/CD86/JAML/RAP1A/MYL12A/ICAM2/DYNLL1/PRKCB/ITGA4/LYN/MYL6/CTNNB1/MAPK8/FYN/PAK1/RDX/NPHS1/ACTG1/DOK2/MAP2K1/CD244/CRTAM/TUBA4A/ROBO1/RAPGEF2/PRKCA/WASL/PMP22/MYL12B/RASA1/ABL1/GSK3B/RAP1B/CD2AP/ARPC2/FOXO1/PDPK1/LCP2/VAV1	0.140586164296243
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1229	57/9376	1.07073215993605	ACSL5/HACD4/ACSL3/ELOVL5/HADHA/SCP2/ACAT2/ACADM	0.20803308705222
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/1229	163/9376	1.02967647895691	STAT1/PRKCB/JAK2/TRAF3/BID/TAB2/VDAC3/TLR2/IL6/MAPK8/SLC10A1/MAP3K1/CREB1/NFATC3/MAP2K1/SOS1/MAP2K4/STAT4/PRKCA/ATF2/YWHAB/YWHAQ	0.148445952182991
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1229	95/9376	1.04396385593765	HLA-DQA2/HLA-DRB5/CCL3L1/CD86/ATP6V1G1/IL15/TNFSF13B/TLR2/ATP6V0E1/IL6/ATP6V1D/MMP1/ATP6V0C	0.167271870691487
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/1229	50/9376	1.06805532953621	HLA-DQA2/HLA-DRB5/CD86/IL15/TNFSF13B/ITGA4/IL6	0.187396795159296
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/1229	134/9376	1.02478656352088	PRKCE/PRKCH/ADCY3/PLA2G6/PPP1CC/PRKCB/PLCB1/MYL6/PLA2G4C/MAP2K1/PPP1R12B/PPP1CA/ITPR1/PRKCA/GNAQ/PLA2G4A/EDN1/PPP1R12A	0.112240206673104
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/1229	180/9376	1.01719555193925	HLA-DQA2/HLA-DRB5/PILRA/STAT1/PPP1CC/JAK2/TRAF3/BID/SRSF9/TAB2/TLR2/IL6/ALYREF/EIF4EBP1/EIF2B3/RHEB/CALR/PPP1CA/NXF1/EIF2S1/IFNGR1/OAS1/EIF2B1/EIF2B2	0.0904722962214393
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1229	20/9376	1.14434499593165	GMDS/NANS/CMAS	0.250977243647711
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1229	43/9376	1.06450697295968	ACSL5/ACSL3/HADHA/ACAT2/ALDH9A1/ACADM	0.164661845700927
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/1229	66/9376	1.04031363266514	HLA-DQA2/HLA-DRB5/STAT1/TLR2/IL6/SMAD2/STAT4/IFNGR1/IL12RB1	0.127647344080221
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/1229	158/9376	1.01397657867362	CDC26/RBX1/CCNH/CDKN1B/CUL1/STAG1/PPP2R5C/SMAD2/CCND3/ANAPC11/PPP2R5E/CDC27/ATR/ANAPC16/YWHAB/CDKN2D/ABL1/GSK3B/YWHAQ/TFDP1/ATM	0.0688135220260684
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1229	97/9376	1.02243882798017	CAMK2D/ADCY3/PRKCB/PLCB1/GNG5/GNG7/GNG2/CREB1/RPS6KA5/ITPR1/PRKCA/GNAQ/GNB1	0.0862776227895878
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1229	105/9376	1.01719555193925	MALT1/TNFSF13B/LY96/PTGS2/PRKCB/CCL4L2/LYN/TRAF3/TAB2/BCL2A1/RELB/BTK/PARP1/ATM	0.0688192920622187
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1229	59/9376	1.03443615451449	FOXO3/CTNNB1/TCF7L2/MAP2K1/SOS1/PTEN/GSK3B/PDPK1	0.103054112470412
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1229	36/9376	1.05957869993671	POLE4/RPA2/PRIM2/RPA3/RFC1	0.139101417619363
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/1229	136/9376	1.00971617288087	RACK1/EIF3H/STAT1/TRAF3/BID/TAB2/HSPA8/TLR2/IL6/MAPK8/CDKN1B/CCND3/EIF2S1/OAS1/CBLB/GSK3B/TLR7/RAB9A	0.0443293561664773
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	27/1229	205/9376	1.00479072813511	HLA-DQA2/HLA-DRB5/STAT1/FCER2/SEM1/LYN/TRAF3/BID/TAB2/TLR2/IL6/MAPK8/CDKN1B/PSMD12/PSMD8/PSMD7/CCND3/MAP2K4/CIR1/CALR/PSMD13/ENTPD1/RELB/BTK/OAS1/SAP30/BCL2L11	0.0269359831341145
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/1229	90/9376	1.01719555193925	STAT1/JAK2/CD4/TLR2/BATF3/NFATC3/MAP2K1/PPP3CC/ALK/PPP3CB/PTEN/IFNGR1	0.0636628030916866
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1229	13/9376	1.17368717531451	XRCC5/XRCC4	0.243385464802645
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1229	44/9376	1.04031363266514	APEX1/POLE4/POLB/PARP4/RFC1/PARP1	0.104100694983864
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/1229	75/9376	1.01719555193925	GSTP1/PMAIP1/ERCC1/BID/REV3L/GSTO2/MGST2/PDPK1/GSTO1/ATM	0.0580690406625554
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1229	83/9376	1.01106786789142	CASP1/CCL4L2/POLR2L/POLR1D/IL6/IFI16/AIM2/PYCARD/POLR2F/ZBP1/PCBP1	0.0393357799481933
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/1229	130/9376	0.997634099017337	ADCY3/PLCB1/GNG5/GNG7/GNG2/MAPK8/CREB1/MAP2K1/SMAD2/SOS1/MAP2K4/PRKCA/ATF2/MMP1/ARRB1/GNB1/EDN1	-0.0105500378498674
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/1229	300/9376	0.991765663140765	MAP4K3/MEF2C/RAP1A/RAC2/PRKCB/MAP3K20/MAP4K4/MAP2K5/TAB2/HSPA8/STK3/NLK/PLA2G4C/MAPK8/PAK1/MAP3K1/NFATC3/DUSP5/MAP2K1/PPP3CC/CACNA2D3/SOS1/PPP3CB/MAP2K4/RAPGEF2/RPS6KA5/MAX/PRKCA/RELB/RASA2/ATF2/LAMTOR3/RASA1/ARRB1/PLA2G4A/MKNK2/RAP1B/RPS6KA2/INSR	-0.0562995255368467
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1229	115/9376	0.995082605157958	NACA/MEF2C/ADCY3/PRKCB/PLCB1/MMP24/CREB1/MAP2K1/PDE4D/PLD1/ITPR1/PRKCA/ATF2/ARRB1/GNAQ	-0.0206071428144498
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1229	200/9376	0.991765663140765	RPS3/ARPC3/RAB1A/CASP4/BRK1/CASP1/SEC24B/TAB2/HCLS1/GAPDH/IL6/MAPK8/FYN/PAK1/TNFSF10/PYCARD/ACTG1/LPAR1/TUBA4A/WIPF1/ABI1/WASL/NCKAP1L/SEC24A/ABL1/ARPC2	-0.0457172023994823
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1229	154/9376	0.990774888252512	CAMK2D/ADCY3/PPP1CC/PLCB1/PIK3R5/PIK3CG/CREM/KCNQ1/CREB1/PPP2R5C/CACNA2D3/RPS6KA5/PPP2R5E/PPP1CA/PRKCA/ATP2A2/ATF2/ATP1B1/GNAQ/POPDC2	-0.0448313852731166
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/1229	61/9376	1.00052021502221	FTH1/FTL/MT2A/SLC30A1/ATOX1/MT1X/HMOX1/ATP1B1	0.0015831391852032
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1229	69/9376	0.995082605157958	PLCB1/CREB1/PPP3CC/PPP3CB/ITPR1/PDE1B/GNAQ/PDE3B/EDN1	-0.0159227285469481
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1229	69/9376	0.995082605157958	CAMK2D/PPP1CC/PRKCB/CREB1/PPP3CC/PPP3CB/PPP1CA/PRKCA/ATF2	-0.0159227285469481
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1229	38/9376	1.00381139994005	NAMPT/NT5C2/BST1/CD38/SIRT3	0.00914349239072747
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1229	38/9376	1.00381139994005	PRKCB/PRKCA/ATP1B1/PDPK1/INSR	0.00914349239072747
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1229	46/9376	0.995082605157958	FTH1/FTL/BLVRB/EPRS1/BLVRA/HMOX1	-0.0129848188978292
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1229	101/9376	0.98194620112947	CAMK2D/ADCY3/PRKCB/PLCB1/CTNNB1/CREB1/TCF7L2/MAP2K1/PRKCA/GNAQ/GSK3B/MITF/EDN1	-0.0708492160468837
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1229	54/9376	0.988940119940934	ERCC1/RPA2/REV3L/RPA3/ATR/WDR48/FANCA	-0.031655958601767
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/1229	109/9376	0.979867274803861	HLA-DQA2/HLA-DRB5/STAT1/JAK2/CD4/IL6/MAPK8/NFATC3/SMAD2/PPP3CC/PPP3CB/IFNGR1/IL6ST/IL12RB1	-0.0821124394401098
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1229	62/9376	0.98438279219927	NUMB/MAML3/ATXN1/CTBP2/CIR1/NOTCH2/APH1A/NRARP	-0.0479174654568858
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	19/1229	149/9376	0.97282124933787	GAB2/ADCY3/PLCB1/PIK3R5/PIK3CG/PLA2G4C/FYN/MAP2K1/SOS1/LPAR1/LPAR6/PLD1/RHEB/PRKCA/GAB1/PIP5K1B/PLA2G4A/FCER1A/INSR	-0.129883829480586
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1229	55/9376	0.970959390487462	SGMS1/ACER3/CERS6/ASAH1/NEU4/CERS4/B4GALT5	-0.0838916119815134
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1229	63/9376	0.968757668513567	TBXAS1/PTGS2/PLA2G6/PLA2G4C/CBR1/PTGDS/PTGR3/PLA2G4A	-0.0966343724716555
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1229	23/9376	0.995082605157958	RPA2/RPA3/RFC1	-0.00917035722562448
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1229	23/9376	0.995082605157958	ATP6AP2/NLN/PREP	-0.00917035722562448
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1229	71/9376	0.967052109238016	ATP6V1G1/LYN/ATP6V0E1/MAPK8/PAK1/ATP6V1D/MAP2K4/ADAM10/ATP6V0C	-0.108233405762567
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/1229	181/9376	0.969426700052596	HLA-DQA2/CTSS/HLA-DRB5/RAB7A/FCGR2C/MALT1/CAMK2D/STAT1/JAK2/RIPK2/BID/TLR2/IL6/MAPK8/CREB1/NFYC/PPP3CC/PPP3CB/KSR1/FCGR3B/IFNGR1/ATP6V0C/CR1	-0.161312662443026
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/1229	87/9376	0.964581988907906	PMAIP1/RAC2/CTNNB1/MAPK8/TCF7L2/MAP2K1/SMAD2/SOS1/APPL1/GSK3B/BCL2L11	-0.128902706464206
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/1229	103/9376	0.962879284602684	PABPC1/PPP1CC/EIF4A3/SAP18/ALYREF/NXT1/PPP2R5C/RNGTT/MAGOH/PPP2R5E/PPP1CA/NXF1/SMG7	-0.147125360967297
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1229	15/9376	1.01719555193925	ST6GALNAC3/ST3GAL5	0.025885904741848
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1229	15/9376	1.01719555193925	TPK1/ACP1	0.025885904741848
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1229	24/9376	0.953620829943043	EXT1/HS3ST3B1/GLCE	-0.0883566143167607
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/1229	89/9376	0.942905989157166	ADCY3/PRKCB/PLCB1/MAP2K5/MAP2K1/SOS1/LPAR1/TUBA4A/ITPR1/PRKCA/GNAQ	-0.21018927646354
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1229	41/9376	0.930361785310286	DAPK1/THBS1/MAP2K1/RPS6KA5/MMP1	-0.173558191996038
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1229	33/9376	0.924723229035678	IDH3G/BCAT1/ACO2/IDH3A	-0.168243191656437
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1229	82/9376	0.930361785310286	GSTP1/CDA/CMPK1/DUT/UPB1/ITPA/GSTO2/MGST2/GSTO1/HPRT1	-0.245989144559472
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/1229	82/9376	0.930361785310286	HLA-DQA2/CTSS/HLA-DRB5/HSPA5/CD4/HSPA8/CREB1/NFYC/CALR/KLRD1	-0.245989144559472
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/1229	170/9376	0.942401761355478	ARPC3/PRKCE/RAP1A/MYL12A/MYL6/HCLS1/MAPK8/MAP3K1/RDX/ACTG1/RAB8B/CD1D/TUBA4A/RAPGEF2/RAB8A/ARHGEF18/PALS1/DLG1/MYL12B/ARPC2/TIAM1	-0.294347871579154
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/1229	170/9376	0.942401761355478	GSTP1/PRKCB/CTNNB1/ACTG1/TCF7L2/MAP2K1/SMAD2/ARID1A/SOS1/FRAT2/PTEN/PRKCA/GAB1/GSTO2/ARID2/HMOX1/SMARCC1/GSK3B/ACTL6A/MGST2/GSTO1	-0.294347871579154
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1229	50/9376	0.915475996745321	SAT2/OAT/SMS/ALDH9A1/LAP3/ODC1	-0.232744847933377
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/1229	139/9376	0.933039085411898	ADCY3/PLCB1/NCOA2/KRT10/KRT24/HSPA8/NCOA1/CREB1/MAP2K1/SOS1/OPRM1/KRT14/ITPR1/NCOA3/ATF2/KRT17/GNAQ	-0.308905774384251
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/1229	227/9376	0.941017911485646	CCL3L1/RAC2/ADCY3/PTGS2/PRKCB/PLCB1/CCL4L2/BID/GNG5/GNG7/CTNNB1/GNG2/IL6/CREB1/EIF4EBP1/NFATC3/MAP2K1/PPP3CC/SOS1/PPP3CB/RHEB/CALR/ITPR1/PRKCA/ATF2/GNAQ/GSK3B/GNB1	-0.349388802978622
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/1229	116/9376	0.920737353048455	NCF2/RAP1A/RAC2/MYL12A/PRKCB/ITGA4/CTNNB1/ACTG1/CYBA/PRKCA/NCF4/MYL12B/RAP1B/VAV1	-0.333622086487467
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/1229	100/9376	0.915475996745321	HLA-DQA2/CD37/HLA-DRB5/FCER2/CD33/CD4/ITGA4/IL6/IL3RA/CD1D/CD38/CR1	-0.330036831904427
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1229	76/9376	0.903430259946041	ACSL5/UBC/ACSL3/PLIN2/SCP2/DBI/MMP1/PDPK1/ACADM	-0.328298656697109
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1229	26/9376	0.880265381485886	PLA2G6/PLA2G4C/PLA2G4A	-0.23744516184314
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/1229	117/9376	0.9128678030224	MACROH2A1/H2AZ1/H2AZ2/H2AC20/H2AJ/BICRAL/ACTG1/ARID1A/CDK2AP1/GATAD2A/ARID2/SMARCC1/GATAD2B/ACTL6A	-0.368342876164024
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/1229	109/9376	0.909876755175014	CCL3L1/CD86/STAT1/LY96/CCL4L2/TRAF3/TAB2/TLR2/IL6/MAPK8/MAP2K1/MAP2K4/TLR7	-0.367572666429531
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/1229	101/9376	0.906411877965665	PRKCE/STAT1/PRKCB/PLCB1/JAK2/IL6/MAPK8/CDKN1B/SMAD2/PRKCA/FOXO1/EDN1	-0.367271460426883
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1229	52/9376	0.880265381485886	ADCY3/PTGS2/PLA2G4C/BMP6/PLA2G4A/INSR	-0.336266029331679
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1229	18/9376	0.847662959949372	ACSL5/ACSL3	-0.251253989573909
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1229	18/9376	0.847662959949372	MMADHC/ZNF143	-0.251253989573909
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1229	86/9376	0.887089144133063	CAMK2D/ADCY3/PRKCB/PLCB1/TRPM4/CREB1/PRKCA/ATF2/ATP1B1/GNAQ	-0.408544896296062
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1229	27/9376	0.847662959949372	HACD4/ELOVL5/SCP2	-0.307870116873113
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1229	36/9376	0.847662959949372	HK2/PYGL/GYG1/GBE1	-0.35566902684162
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1229	70/9376	0.871881901662211	HLA-DQA2/HLA-DRB5/CD86/RAC2/BID/FYN/ACTG1/ABL1	-0.417869526683624
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/1229	45/9376	0.847662959949372	HLA-DQA2/HLA-DRB5/CD86/IL6/KLRD1	-0.397841786613943
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/1229	112/9376	0.885505056375683	HLA-DQA2/HLA-DRB5/STAT1/LY96/JAK2/PIK3R5/TAB2/PIK3CG/HSPA8/TLR2/MAPK8/IFNGR1/PDPK1	-0.47343326236666
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1229	71/9376	0.859601874878236	FOXO3/STAT1/JAK2/MAPK8/MAP2K1/SOS1/PRLR/GSK3B	-0.461206070955549
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1229	28/9376	0.817389282808323	HACD4/ELOVL5/HADHA	-0.375844887835131
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1229	19/9376	0.803049119952036	GNS/ARSB	-0.333756039283383
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/1229	37/9376	0.82475315022101	CTNNB1/TFG/TCF7L2/MAP2K1	-0.414823752388737
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/1229	154/9376	0.891697399427261	ADSS2/EPRS1/PPCDC/KMO/GPHN/GCH1/PTS/CMPK1/TPK1/BCAT1/GCLC/AFMID/MAT2B/PANK2/IDO1/PPCS/IDO2/COQ2	-0.526319436041438
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/1229	63/9376	0.847662959949372	CAMKMT/SMYD3/HADHA/TMLHE/ACAT2/ALDH9A1/PHYKPL	-0.471187442456873
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1229	72/9376	0.847662959949372	TANK/ATG5/TRAF3/MAPK8/MAP3K1/AZI2/PIN1/ZNFX1	-0.503964136258442
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/1229	212/9376	0.899642292399097	SIPA1L1/RAP1A/RAC2/ADCY3/DOCK4/PRKCB/PLCB1/SIPA1L3/THBS1/CTNNB1/FARP2/FPR1/ACTG1/MAP2K1/LPAR1/RAPGEF2/PRKCA/RAPGEF1/GNAQ/EVL/RAP1B/TIAM1/LCP2/VAV1/INSR	-0.574035622829828
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1229	29/9376	0.789203445470105	STK3/PAK1/TPTEP2-CSNK1E	-0.441559372145216
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1229	47/9376	0.811592195696207	PRKCE/HK2/MAPK8/IRS2/INSR	-0.502913150828785
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1229	115/9376	0.86240492447023	PTGS2/PRKCB/PLCB1/GNG5/GNG7/PLA2G4C/GNG2/MAP2K1/ITPR1/PRKCA/GNAQ/PLA2G4A/GNB1	-0.576614541456987
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	8/1229	73/9376	0.836051138580202	FOXO3/PRKCB/FHIT/MAP2K1/SOS1/ALK/PRKCA/PDPK1	-0.546161453996705
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1229	65/9376	0.82158102272016	ADCY3/PLCB1/PDE8A/CREB1/ITPR1/ATF2/GNAQ	-0.560611861129498
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1229	65/9376	0.82158102272016	PRKCB/PLCB1/MAP2K1/ITPR1/PRKCA/ARRB1/GNAQ	-0.560611861129498
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1229	30/9376	0.762896663954435	PLA2G6/PLA2G4C/PLA2G4A	-0.505182299086621
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/1229	49/9376	0.778465983626974	ST6GAL1/GALNT1/OGT/C1GALT1/GALNT3	-0.603851562464972
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/1229	31/9376	0.738287094149453	HADHA/UPB1/ALDH9A1	-0.566864232444906
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1229	67/9376	0.797056216071797	HK2/GAPDH/LDHB/TPI1/ALDH9A1/PGAM1/FBP1	-0.647477023118479
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1229	93/9376	0.820318993499392	LYZ/ADCY3/PRKCB/PLCB1/BST1/ITPR1/PRKCA/ATP1B1/GNAQ/CD38	-0.676335513408678
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/1229	76/9376	0.803049119952036	CAMK2D/CAMK1D/CAMK1/PRKCB/MAP2K1/SOS1/PTEN/PRKCA	-0.669554555277164
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1229	144/9376	0.847662959949372	FOXO3/LY96/LPIN2/TRAF3/TAB2/CTNNB1/ADIPOR1/IL6/MAPK8/TCF7L2/MAP2K4/ALDH9A1/GSK3B/FOXO1/LPIN1/ACADM	-0.715486728550345
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1229	22/9376	0.693542421776759	HNMT/ALDH9A1	-0.558914973133088
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/1229	103/9376	0.814744010048425	CCL3L1/PLCB1/TLR2/IL6/MAPK8/SMAD2/MAP2K4/CALR/IFNGR1/GNAQ/GNAL	-0.734249167917448
Human Diseases	Immune disease	hsa05310	Asthma	3/1229	32/9376	0.715215622457282	HLA-DQA2/HLA-DRB5/FCER1A	-0.626740063442635
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1229	12/9376	0.635747219962029	COQ2	-0.490371833843774
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1229	12/9376	0.635747219962029	NPC1	-0.490371833843774
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/1229	205/9376	0.855932842485463	GTF2A2/PMAIP1/LYN/TRAF3/SND1/VDAC3/HDAC9/RANBP1/CDKN1B/CREB1/CCND3/H4C3/GTF2A1/RASA2/ATF2/POLB/YWHAB/DLG1/HDAC4/UBE3A/IL6ST/YWHAQ/GTF2B	-0.810021027190524
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1229	23/9376	0.663388403438639	CA2/ATP1B1	-0.627740640300836
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/1229	362/9376	0.885128726134979	RPS6/FOXO3/PHLPP1/JAK2/PIK3R5/RPTOR/THBS1/ITGA4/PIK3CG/GNG5/TLR2/GNG7/GNG2/IL6/CDKN1B/CREB1/EIF4EBP1/IL3RA/MAP2K1/PPP2R5C/PIK3AP1/SOS1/LPAR1/EIF4B/LPAR6/CCND3/PTEN/RHEB/C8orf44-SGK3/PPP2R5E/PRKCA/ATF2/YWHAB/PRLR/GSK3B/YWHAQ/PDPK1/GNB1/ITGB8/COL6A2/INSR/BCL2L11	-0.865704484192107
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1229	70/9376	0.762896663954435	ACSL5/JAK2/ACSL3/ADIPOR1/MAPK8/APPL1/IRS2	-0.77333538425808
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1229	70/9376	0.762896663954435	GSTK1/GSTP1/PTGS2/CBR1/GSTO2/MGST2/GSTO1	-0.77333538425808
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/1229	157/9376	0.82606645141563	PPP1CC/STK3/CTNNB1/BMP6/ACTG1/TCF7L2/SMAD2/CCND3/PPP1CA/YWHAB/BMP5/PALS1/DLG1/GSK3B/YWHAQ/TPTEP2-CSNK1E/FBXW11	-0.853599196692057
Human Diseases	Substance dependence	hsa05034	Alcoholism	21/1229	191/9376	0.838786908012729	H3-3B/H3-3A/MACROH2A1/H2AZ1/H2AZ2/H2AC20/H2AJ/PPP1CC/GNG5/HDAC9/GNG7/GNG2/CREB1/MAP2K1/SOS1/H4C3/PPP1CA/ATF2/HDAC4/GNB1/HAT1	-0.874259041434338
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/1229	106/9376	0.791685217311206	GSTP1/CTNNB1/CDKN1B/CREB1/TCF7L2/MAP2K1/SOS1/PTEN/GSK3B/FOXO1/PDPK1	-0.837714199699332
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/1229	71/9376	0.752151640518457	HK2/SCO2/LDHB/MAP2K1/PTEN/PGAM1/SIRT3	-0.814178736148531
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1229	99/9376	0.770602690863065	HLA-DQA2/HLA-DRB5/FCGR2C/KRT10/KRT24/FPR1/FPR2/KRT14/FCGR3B/KRT17	-0.891178826887063
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1229	14/9376	0.544926188538882	CHST2	-0.661796192823003
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	26/1229	238/9376	0.833416523647702	GAB2/RAP1A/RAC2/PLA2G6/PRKCB/GNG5/GNG7/PLA2G4C/GNG2/MAPK8/PAK1/MAP2K1/SOS1/PLD1/KSR1/EXOC2/PRKCA/GAB1/RASA2/RASA1/ABL1/PLA2G4A/RAP1B/TIAM1/GNB1/INSR	-1.01101487197575
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/1229	110/9376	0.762896663954435	DCN/THBS1/RBX1/CUL1/BMP6/NRROS/SMAD2/ACVR2A/ACVR1B/BMP5/TFDP1	-0.971517394197374
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1229	110/9376	0.762896663954435	ADCY3/CDC26/MAPK8/MAP2K1/CPEB4/ANAPC11/CDC27/ANAPC16/CPEB3/PDE3B/RPS6KA2	-0.971517394197374
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1229	65/9376	0.704212305188709	GPAT3/LPIN2/AKR1B1/LIPC/ALDH9A1/LPIN1	-0.92939715615161
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/1229	119/9376	0.769307560290186	IL15/PTGS2/TRAF3/TAB2/IL6/MAPK8/CREB1/MAP2K1/MAP2K4/RPS6KA5/ATF2/EDN1	-0.983636039057058
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/1229	155/9376	0.787506233759416	CAMK2D/RAP1A/ADCY3/PLCB1/PDE8A/CTNNB1/CDKN1B/CREB1/TCF7L2/MAP2K1/ITPR1/ATF2/AIP/GNAQ/GSK3B/RAP1B	-1.03606201993819
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1229	37/9376	0.618564862665758	ADSS2/GLUL/ASRGL1	-0.902888440856149
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/1229	103/9376	0.740676372771296	RAB7A/PRKCB/PLCB1/TLR2/IL6/CD1D/PRKCA/GNAQ/GNAL/SERPINB10	-1.02781107139252
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1229	27/9376	0.565108639966248	HADHA/ACAT2	-0.878906756992264
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1229	48/9376	0.635747219962029	HK2/PRKCB/PLCB1/ATP1B1	-0.982634360887149
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1229	38/9376	0.602286839964027	HK2/GALK2/PGM3	-0.954108020591997
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/1229	77/9376	0.693542421776759	RAC2/STAT1/MAPK8/MAP2K1/SMAD2/PLD1/ARHGEF6	-1.0487218714848
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/1229	184/9376	0.787773729083383	CAMK2D/RAC2/MYL12A/FYN/PAK1/NFATC3/PPP3CC/PPP3CB/ROBO1/SSH2/CFL1/SEMA4D/PRKCA/SEMA3C/MYL12B/RASA1/ABL1/GSK3B/PDPK1	-1.12918673632296
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1229	59/9376	0.646522596571555	ADCY3/PTGS2/IRS2/PDE3B/INSR	-1.05782136833365
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1229	39/9376	0.586843587657257	HLA-DQA2/HLA-DRB5/CD86	-1.00416676445483
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1229	79/9376	0.67598438578241	GSTK1/GSTP1/AKR7A2/CBR1/GSTO2/MGST2/GSTO1	-1.12323542228994
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1229	50/9376	0.610317331163548	THBS1/TLR2/IL6/CR1	-1.07302813411872
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1229	17/9376	0.448762743502609	SCP2	-0.883509087962332
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/1229	143/9376	0.746891838836509	H3-3B/HLA-DQA2/H3-3A/MACROH2A1/H2AZ1/HLA-DRB5/H2AZ2/H2AC20/CD86/H2AJ/C7/SNRPD1/H4C3/FCGR3B	-1.18458293275824
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1229	41/9376	0.558217071186172	GRHPR/SDSL/PGAM1	-1.10104842177937
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1229	18/9376	0.423831479974686	NEU4	-0.95029179558132
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/1229	226/9376	0.776399259776637	CAMK2D/RAP1A/RAC2/ADCY3/PPP1CC/MAPK8/PAK1/CREB1/MAP2K1/PDE4D/PLD1/PPP1CA/ATP2A2/HCAR3/HCAR2/ATP1B1/RAP1B/PDE3B/TIAM1/VAV1/EDN1/POPDC2/PPP1R12A	-1.32153792529431
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1229	32/9376	0.476810414971522	HK2/AKR1B1	-1.1514110308389
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1229	54/9376	0.565108639966248	HLA-DQA2/HLA-DRB5/CD86/TG	-1.24476059559155
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1229	94/9376	0.649273756556966	PTGS2/TRAF3/TAB2/IL6/MAPK8/USP25/MMP1/GSK3B	-1.32731538959952
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1229	20/9376	0.381448331977217	SOAT1	-1.07549549391764
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1229	44/9376	0.520156816332569	HLA-DQA2/HLA-DRB5/CD86	-1.23908478598225
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1229	86/9376	0.620962400893144	ITGA4/CTNNB1/ACTG1/TCF7L2/CACNA2D3/ATP2A2/ITGB8	-1.3714702225082
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/1229	77/9376	0.594464932951507	GAB2/CDKN1B/MAP2K1/SOS1/CTBP2/ABL1	-1.38777280997111
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/1229	78/9376	0.586843587657257	CASP1/LY96/IL6/MAPK8/PYCARD/CFL1	-1.42308142328729
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/1229	68/9376	0.560953429378261	EIF4EBP1/TCF7L2/MAP2K1/SOS1/BCL2A1	-1.41123578289868
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1229	254/9376	0.750882543262239	CAMK2D/SLC25A5/CAMK1D/ADCY3/CAMK1/PRKCB/PLCB1/CYSLTR1/VDAC2/VDAC3/MCU/SLC25A6/NFATC3/PPP3CC/PPP3CB/ITPKB/ITPR1/PRKCA/ATP2A2/CYSLTR2/STIM1/PDE1B/GNAQ/CD38/GNAL	-1.56328696742592
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/1229	201/9376	0.721146100255436	H3-3B/H3-3A/CD86/MEF2C/FLI1/KDM6A/ETV6/PBX3/NFKBIZ/IL6/CDKN1B/LYL1/MAX/BCL2A1/LMO2/PRCC/FOXO1/MITF/ATM	-1.5521526695349
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1229	79/9376	0.579415187813495	ATP6V1G1/ATP6V0E1/CLTA/AP2S1/ATP6V1D/ATP6V0C	-1.45800306650591
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1229	36/9376	0.423831479974686	AKR1B1/CRYL1	-1.34520991576359
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1229	23/9376	0.331694201719319	GLUL	-1.24631092337605
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1229	38/9376	0.401524559976018	CD4/BTK	-1.43573377708336
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/1229	103/9376	0.592541098217036	SLC7A7/KCNE3/KCNQ1/SLC16A10/CELA2B/ATP1B1/COL15A1/COL6A2	-1.61493487834267
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/1229	93/9376	0.574223295449574	PTGS2/FHIT/TRAF3/CDKN1B/PTEN/MAX/CKS1B	-1.60266191556865
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1229	73/9376	0.522531961612626	GSTK1/GSTP1/GSTO2/MGST2/GSTO1	-1.59058523386069
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/1229	333/9376	0.756023721035926	ATP6V1G1/STAT1/PTGS2/THBS1/ITGA4/TRAF3/MAML3/ATP6V0E1/CTNNB1/CDKN1B/CREB1/EIF4EBP1/TCF7L2/MAP2K1/PPP2R5C/SOS1/ATP6V1D/CCND3/PTEN/RHEB/PPP2R5E/ATR/NOTCH2/PALS1/DLG1/UBE3A/GSK3B/ATP6V0C/FOXO1/ATM/ITGB8/COL6A2/NFX1	-1.76066275039366
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1229	39/9376	0.391229058438172	AHCYL2/MAT2B	-1.47960319244698
NA	NA	hsa04518	Integrin signaling	13/1229	154/9376	0.644003677364133	RAC2/ICAM2/THBS1/ITGA4/CTNNB1/ITGAE/ACTG1/CCND3/ARHGEF6/PARVB/GSK3B/ITGB8/COL6A2	-1.73003956296224
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/1229	26/9376	0.293421793828629	CUBN	-1.40121193520502
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	16/1229	183/9376	0.667013476681473	TCOF1/XRN2/NXT1/SNU13/XRN1/NHP2/EIF6/RPP30/NXF1/NOP10/POP4/POP5/GTPBP4/UTP6/EFL1/PWP2	-1.7667955361148
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/1229	156/9376	0.635747219962029	EIF3E/PIAS1/STAT1/TRAF3/BID/CTNNB1/MAP2K1/SOS1/EIF2S1/YWHAB/OAS1/GSK3B/YWHAQ	-1.78181428008153
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/1229	168/9376	0.635747219962029	PIAS1/IL15/STAT1/JAK2/IL6/IL3RA/SOS1/CCND3/STAM/STAT4/PRLR/IFNGR1/IL6ST/IL12RB1	-1.85028054370068
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1229	28/9376	0.272463094269441	ST3GAL4	-1.49739856967542
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/1229	99/9376	0.539421883604146	ADCY3/MAPK8/CDKN1B/MAP2K1/SOS1/NCOA3/NOTCH2	-1.7892863129205
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/1229	99/9376	0.539421883604146	ITGA4/IL6/ACTG1/CACNA2D3/ATP2A2/ITGB8/EDN1	-1.7892863129205
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/1229	100/9376	0.534027664768104	CCL3L1/CX3CR1/CCL4L2/CXCL14/IL6/TNFSF10/IL6ST	-1.81945988539688
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/1229	217/9376	0.667974037563791	ADCY3/PRKCB/JAK2/KPNA3/CREB1/EIF4EBP1/MAP2K1/SOS1/CCND3/NOTCH2/PRKCA/ATF2/GSTO2/AIP/ARRB1/KPNA2/MGST2/GSTO1/RPS6KA2	-1.92194344128018
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1229	29/9376	0.263067815156702	GNB1	-1.54366523484548
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/1229	30/9376	0.254298887984811	IL6	-1.58882202368881
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1229	31/9376	0.246095698049818	ALDH9A1	-1.63293965986511
NA	NA	hsa03272	Virion - Hepatitis viruses	2/1229	48/9376	0.317873609981014	SLC10A1/TSG101	-1.84015295430468
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/1229	49/9376	0.31138639345079	CREB1/ATF2	-1.87700475555505
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/1229	63/9376	0.363284125692588	CTNNB1/TCF7L2/GSK3B	-1.96939972239774
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1229	89/9376	0.428593631435076	THBS1/ITGA4/CD47/ITGB8/COL6A2	-2.10360928234551
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/1229	144/9376	0.529789349968357	PCGF5/JAK2/CTNNB1/JARID2/MAP2K1/SMAD2/ACVR2A/ACVR1B/IL6ST/GSK3B	-2.2084548814186
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1229	90/9376	0.423831479974686	ADCY3/AQP9/SLC10A1/CA2/ATP1B1	-2.13313903314047
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1229	68/9376	0.336572057626956	ALDH1A2/DHRS4L2/ALDH1A1	-2.13246911444006
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/1229	148/9376	0.515470718888131	CTNNB1/NCOA1/TCF7L2/MAP2K1/SOS1/FRAT2/PTEN/NCOA3/NOTCH2/GSK3B	-2.30759619277598
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/1229	105/9376	0.435940950831105	ADCY3/ITGA4/ACTG1/CACNA2D3/ATP2A2/ITGB8	-2.25745265881787
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/1229	160/9376	0.524491456468674	HLA-DQA2/HLA-DRB5/CD86/JAML/ICAM2/CD4/VSIR/ITGA4/NEGR1/SPN/ITGB8	-2.35618726401168
Cellular Processes	Cell motility	hsa04814	Motor proteins	14/1229	194/9376	0.550543984297015	MYL12A/DYNLL1/DNAI2/MYL6/DYNLT1/DCTN3/ACTG1/ACTR10/TUBA4A/DCTN6/CAPZA2/MYL12B/KIF2A/DCTN2	-2.45686978778352
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/1229	73/9376	0.313519176967576	MAP2K1/PTEN/MITF	-2.28686775377001
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1229	43/9376	0.177417828826613	ACAT2	-2.09974042078762
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/1229	45/9376	0.169532591989874	ABCB7	-2.16883981215333
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/1229	150/9376	0.457737998372661	CTNNB1/CDKN1B/TCF7L2/MAP2K1/SMAD2/SOS1/FRAT2/GAB1/GSK3B	-2.60022421677683
NA	NA	hsa04081	Hormone signaling	15/1229	219/9376	0.522531961612626	ADCY3/PLCB1/JAK2/GNG5/GNG7/ADIPOR1/GNG2/OPRM1/APPL1/SLC16A10/IRS2/PRLR/GNAQ/GNB1/INSR	-2.77685036111217
NA	NA	hsa04082	Neuroactive ligand signaling	13/1229	199/9376	0.498374705095862	TAC3/ADCY3/PRKCB/PLCB1/P2RY13/GNG5/GNG7/GNG2/OPRM1/PRKCA/GNAQ/GNAL/GNB1	-2.77791096422102
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/1229	88/9376	0.260078408166284	C7/SERPINB2/CR1	-2.70849884645606
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/1229	298/9376	0.537611743055138	CCL3L1/IL15/CX3CR1/TNFSF13B/CCL4L2/CD4/CXCL14/IL6/TNFSF10/BMP6/IL3RA/IL1RL2/IL16/ACVR2A/ACVR1B/BMP5/PRLR/IFNGR1/TNFSF12/IL6ST/IL12RB1	-3.15052231684927
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1229	66/9376	0.11559040362946	HSD17B11	-2.80035632098682
NA	NA	hsa04519	Cadherin signaling	30/1229	404/9376	0.56650742372854	ARPC3/CDH23/KRT6A/ERBIN/RAC2/BRK1/PPP1CC/KRT10/KRT24/STK3/CTNNB1/MAPK8/ACTG1/TCF7L2/MAP2K1/KRT5/KRT14/PPP1CA/NCKAP1L/YWHAB/PALS1/ADAM10/KRT17/APH1A/GSK3B/EVL/ARPC2/YWHAQ/TMC8/VAV1	-3.4593175966101
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1229	86/9376	0.177417828826613	PLCB1/PDE1B	-2.97634576619509
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/1229	323/9376	0.472381835265904	PRKCE/PTGS2/PRKCB/RPTOR/THBS1/CDKN1B/RDX/MAP2K1/SOS1/PDCD4/PTEN/RPS6KA5/NOTCH2/PRKCA/IRS2/HDAC4/ABL1/HMOX1/ATM/BCL2L11	-3.74789539778126
NA	NA	hsa04382	Cornified envelope formation	10/1229	217/9376	0.351565282928311	S100A4/KRT6A/KRT10/KRT24/SPRR3/PPP2R5C/KRT5/KRT14/PPP2R5E/KRT17	-3.75348615039025
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/1229	233/9376	0.360165807017115	DCN/THBS1/ITGA4/PDLIM2/ACTG1/NID1/CAPZA2/MYOM1/ATP1B1/ITGB8/COL6A2	-3.84117211417219
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/1229	370/9376	0.309282431332879	TAC3/UTS2/P2RY8/CYSLTR1/P2RY13/TSPO/FPR1/FPR2/LPAR1/LPAR6/OPRM1/CYSLTR2/PRLR/S1PR4/EDN1	-5.26499683926601
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1229	449/9376	0.135928136116603	CAMK2D/ADCY3/GNG7/PDE2A/PDE1B/ARRB1/GNAL/GNB1	-7.28757417842487