category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	125/2494	222/9376	2.11679201254181	RPS13/RPS21/RPS27A/RPL30/RPL21/RPS4X/RPL39/RPS27/RPL41/RPL10/RPS8/RPL37/RPL34/RPL35A/RPL28/RPS28/RPS24/RPS15A/RPS12/RPL11/RPL3/RPS5/RPS29/RPL32/RPS23/RPL10A/RPL7/RPL37A/RPL15/RPS3/RPL23/RPS7/RPL9/UBA52/RPL12/RPL27/RPS6/RPL8/RPL14/RPL36/RPL27A/RPL18A/RPL13A/RPS2/RPL5/RPL19/RPL23A/RPS16/RPS14/RPS3A/RPS11/RPS19/RPSA/RPLP1/FAU/RPL24/RPS15/RPS26/RPL18/RPL29/RPL6/RACK1/RPL35/RPL38/RPL13/RPS20/RPL22/RPLP0/RPL26/RSL24D1/RPLP2/RPL31/MRPL52/RPL36A-HNRNPH2/MRPL33/MRPL54/MRPL51/MRPL11/MRPL15/MRPS33/RPS10/RPS10-NUDT3/MRPL34/MRPS35/RPL36AL/MRPL20/MRPL43/MRPL36/DAP3/MRPS27/MRPS9/MRPL13/MRPL16/MRPS23/MRPS21/MRPL9/MRPS14/MRPL44/MRPS7/MRPS10/MRPS11/MRPL3/RPL22L1/MRPL18/MRPL39/MRPS31/MRPL21/MRPL42/MRPL35/MRPL40/MRPS34/MRPS18C/MRPS15/MRPL55/MRPL47/MRPL19/MRPS22/MRPL37/MRPL10/MRPS30/MRPS2/MRPL4/RPL26L1/MRPL50/RPL4	10.1372430901657
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	104/2494	205/9376	1.90721927748548	SLC25A5/COX7C/NDUFB5/COX4I1/NDUFB1/ATP5F1E/MAPK8/NDUFA4/UQCRB/COX7A2/SLC25A6/UQCRFS1/UQCRH/CAMK2D/SMAD3/CYBA/COX7A2L/VDAC2/ATP5MC2/PLCB1/COX6C/NDUFAB1/MPC1/NDUFB6/GSK3B/COX5A/PPP1CA/COX6B1/NDUFS4/PRKCB/MPC2/ATP5PB/VDAC3/ATP5MC3/COX7B/TBC1D4/UQCR10/UQCRC2/NFKB1/RAC1/ATP5F1D/PPP1CC/PRKCA/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/SDHB/COL3A1/SDHC/ATP5F1C/NDUFS5/COX5B/NDUFB9/NDUFB7/VDAC1/RAC2/NDUFS2/NDUFV1/MAPK14/NDUFB2/NDUFA12/TGFB1/NDUFS8/PDK3/PIK3CB/NDUFA1/GYS1/ATP5PF/NDUFA5/NDUFS6/INSR/SMAD2/ATP5PO/NDUFS7/NDUFC1/NDUFB10/MAPK10/COX7A1/NDUFV2/ATP5F1A/NCF2/NDUFA2/NDUFA9/PDHB/COX6A1/COX8A/PIK3CA/ATP5MC1/PDK2/TGFBR2/PPARA/UQCRHL/PIK3R1/MMP2/PRKCG/COL1A1/CYBB/ACE/UQCR11/COL1A2/TGFB2/PLCB4	7.9060104199113
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	112/2494	238/9376	1.76914005377612	RPS13/RPS21/RPS27A/RPL30/RPL21/RPS4X/RPL39/RPS27/RPL41/RPL10/RPS8/RPL37/RPL34/RPL35A/RPL28/RPS28/RPS24/RPS15A/RPS12/RPL11/RPL3/RPS5/RPS29/RPL32/RPS23/RPL10A/RPL7/RPL37A/RPL15/RPS3/RPL23/RPS7/RPL9/UBA52/RPL12/RPL27/RPS6/RPL8/RPL14/RPL36/RPL27A/RPL18A/RPL13A/RPS2/RPL5/RPL19/RPL23A/RPS16/RPS14/RPS3A/RPS11/RPS19/RPSA/RPLP1/FAU/RPL24/RPS15/RPS26/RPL18/RPL29/RPL6/RPL35/RPL38/RPL13/MAPK8/TRAF3/RPS20/RPL22/RPLP0/RPL26/RSL24D1/RPLP2/RPL31/TAB2/RPL36A-HNRNPH2/PRKCB/FOS/RPS10/C7/RPS10-NUDT3/NFKB1/RPL36AL/PRKCA/TLR2/TBK1/IRAK4/STAT1/SYK/MAPK14/PIK3CB/C5/RPL22L1/C1S/JAK1/MAPK10/MAPK1/C3AR1/PIK3CA/RPL26L1/MMP1/PIK3R1/ADAM17/RPL4/PRKCG/C1QB/VWF/CYBB/C1QA/ACE/NLRP3/C9/IL6ST	7.2351053390274
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	123/2494	275/9376	1.68148720565721	SLC25A5/COX7C/NDUFB5/COX4I1/NDUFB1/ATP5F1E/MAPK8/CREB1/NDUFA4/UQCRB/COX7A2/SLC25A6/UQCRFS1/UQCRH/HSPA8/EIF2AK3/CYBA/COX7A2L/VDAC2/ATP5MC2/COX6C/NDUFAB1/PSMD8/PPP3CA/PPP3CC/NDUFB6/GSK3B/MCU/COX5A/COX6B1/NDUFS4/CREB5/FYN/PSMB7/ATP5PB/VDAC3/ATP5MC3/COX7B/PSMA5/UQCR10/C7/UQCRC2/RAC1/PSMB1/PPP3CB/ATP5F1D/ITPR1/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/PRKACB/NDUFS5/COX5B/NDUFB9/PSMB5/NDUFB7/VDAC1/RAC2/NDUFS2/NDUFV1/MAPK14/NDUFB2/NDUFA12/NDUFS8/PSMB6/PIK3CB/BAD/NDUFA1/ATP5PF/NDUFA5/NDUFS6/CSNK2A1/C5/PSMC5/EIF2S1/ATP5PO/NDUFS7/NDUFC1/NCAM1/PSMD4/PSMD12/TUBA1A/CAV1/NDUFB10/PSMD2/MAPK10/COX7A1/RYR1/NDUFV2/ATP5F1A/BAX/SOD1/MAPK1/NCF2/PSMA4/NDUFA2/NDUFA9/PSMB2/COX6A1/COX8A/PIK3CA/ATP5MC1/PSMD14/UQCRHL/CACNA1D/PSMD1/PIK3R1/CAV2/TUBB6/ITPR2/C1QB/CYBB/C1QA/UQCR11/NCAM2/C9	6.90487824676181
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	106/2494	227/9376	1.75550130886816	SLC25A5/COX7C/NDUFB5/COX4I1/NDUFB1/ATP5F1E/MAPK8/NDUFA4/UQCRB/MAP3K5/COX7A2/SLC25A6/UQCRFS1/UQCRH/CYBA/COX7A2L/PTPRJ/VDAC2/MAP2K4/ATP5MC2/COX6C/NDUFAB1/FOXO3/NDUFB6/SOS1/COX5A/MAP2K1/COX6B1/NDUFS4/ATP5PB/VDAC3/ATP5MC3/FOS/MGST3/COX7B/UQCR10/UQCRC2/NFKB1/BRAF/MGST2/ABL1/RAC1/PTPN1/ATP5F1D/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/ACP1/NDUFS5/COX5B/NDUFB9/NDUFB7/VDAC1/NDUFS2/NDUFV1/SRC/GSTT1/MAPK14/NDUFB2/SOS2/NDUFA12/NDUFS8/CAT/PIK3CB/BAD/NDUFA1/ATP5PF/NDUFA5/NDUFS6/ATP5PO/NDUFS7/NDUFC1/KRAS/NDUFB10/PRKD3/MAPK10/COX7A1/NDUFV2/ATP5F1A/SOD1/MAPK1/NCF2/NDUFA2/NDUFA9/COX6A1/COX8A/PIK3CA/ATP5MC1/UQCRHL/MAP3K14/EPHX1/PIK3R1/PTK2/GSTM1/AKR1A1/GSTO1/UQCR11/HIF1A/MGST1/LPO/GSTO2	6.93645965330555
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	72/2494	138/9376	1.96143788570831	COX7C/NDUFB5/COX4I1/NDUFB1/ATP5F1E/NDUFA4/UQCRB/COX7A2/UQCRFS1/UQCRH/COX7A2L/ATP5MC2/PPA2/COX6C/NDUFAB1/PPA1/NDUFB6/COX5A/COX6B1/NDUFS4/ATP5PB/ATP5MC3/ATP6V1D/COX7B/UQCR10/ATP6V1G1/UQCRC2/ATP6V0E1/ATP5F1D/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/NDUFS5/COX5B/NDUFB9/NDUFB7/NDUFS2/NDUFV1/NDUFB2/NDUFA12/NDUFS8/NDUFA1/ATP5ME/ATP5PF/NDUFA5/NDUFS6/ATP5PO/ATP6V1E1/NDUFS7/NDUFC1/NDUFB10/COX7A1/COX11/NDUFV2/ATP5F1A/LHPP/ATP6V0A1/NDUFA2/NDUFA9/COX6A1/COX8A/ATP5MC1/ATP5MG/UQCRHL/ATP6V0D1/ATP6V0B/UQCR11	6.84933368278301
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	119/2494	268/9376	1.66929586230835	RPS27A/UBA52/SLC25A5/COX7C/PRKN/NDUFB5/COX4I1/NDUFB1/ATP5F1E/MAPK8/NDUFA4/UQCRB/PARK7/MAP3K5/COX7A2/SLC25A6/UQCRFS1/UQCRH/GNAL/CAMK2D/EIF2AK3/COX7A2L/VDAC2/ATP5MC2/ATF6/COX6C/NDUFAB1/PSMD8/SLC39A11/NDUFB6/MCU/COX5A/COX6B1/NDUFS4/SNCA/PSMB7/ATP5PB/VDAC3/ATP5MC3/UBE2L6/COX7B/PSMA5/UQCR10/UBE2G1/UQCRC2/GNAI3/DUSP1/TXN2/PSMB1/ATP5F1D/ITPR1/CALM2/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/PRKACB/NDUFS5/COX5B/NDUFB9/PSMB5/NDUFB7/VDAC1/NDUFS2/NDUFV1/NDUFB2/NDUFA12/SLC39A9/NDUFS8/SLC18A2/PSMB6/NDUFA1/ATP5PF/NDUFA5/NDUFS6/MFN1/PSMC5/EIF2S1/ATP5PO/NDUFS7/NDUFC1/PSMD4/PSMD12/TUBA1A/NDUFB10/PSMD2/MAPK10/COX7A1/NDUFV2/ATP5F1A/BAX/SOD1/SNCAIP/PSMA4/NDUFA2/NDUFA9/PSMB2/COX6A1/COX8A/UBE2J1/ERN1/ATP5MC1/PSMD14/UQCRHL/PSMD1/TH/TUBB6/ITPR2/HTRA2/GNAI1/CALM3/UQCR11/CALM1	6.69191713941183
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	107/2494	235/9376	1.71173710522275	RPS6/COX7C/NDUFB5/COX4I1/NDUFB1/ATP5F1E/CREB1/NDUFA4/UQCRB/MAP3K5/COX7A2/UQCRFS1/UQCRH/ADCY3/ACTG1/COA1/COX7A2L/ATP5MC2/ACSL5/PPARG/RPTOR/COX6C/NDUFAB1/NDUFB6/SOS1/COX14/RPS6KA3/COX5A/COX6B1/NDUFS4/CREB5/ATP5PB/FRS2/ATP5MC3/NDUFAF2/COX7B/UQCR10/KDM3B/COA3/UQCRC2/ARID1B/RHEB/ZNF516/ATP5F1D/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/PRKACB/NDUFS5/COX5B/NDUFB9/NDUFB7/RPS6KB2/NDUFS2/NDUFV1/MAPK14/COA4/NDUFB2/SOS2/NDUFA12/NDUFS8/RPS6KA2/SMARCC1/NDUFA1/ATP5ME/ATP5PF/NDUFA5/NDUFS6/COA6/ATP5PO/NDUFS7/NDUFC1/NDUFAF6/KRAS/NDUFAF4/NDUFB10/ADCY9/COX19/COX7A1/COX11/NDUFV2/ATP5F1A/COA5/NDUFA2/NDUFA9/COX6A1/COX8A/ACTL6A/ATP5MC1/ACSL1/ATP5MG/NDUFAF8/PRKG1/UQCRHL/SLC25A20/NDUFAF5/NDUFAF1/SMARCD3/UQCR11/ADCY10/NPPA/LIPE	6.65170856419386
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	152/2494	368/9376	1.55280499285241	GPX1/C9orf72/COX7C/PRKN/NDUFB5/AMBRA1/COX4I1/RAB1A/NDUFB1/ATP5F1E/NDUFA4/UQCRB/TANK/MAP3K5/COX7A2/UQCRFS1/UQCRH/EIF2AK3/ACTG1/COX7A2L/NUP214/ATP5MC2/BID/ATF6/COX6C/NDUFAB1/DCTN3/PSMD8/PPP3CA/PPP3CC/NDUFB6/MCU/WIPI1/NUP98/COX5A/COX6B1/NDUFS4/PSMB7/ATP5PB/ACTR10/ATP5MC3/DNAI2/COX7B/PSMA5/UQCR10/ATXN2/UQCRC2/RAC1/NUP54/BCL2/HNRNPA1/DCTN2/PSMB1/PPP3CB/ATP5F1D/DCTN4/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NXT1/NDUFB3/SDHB/SDHC/ATP5F1C/NDUFS5/TBK1/MATR3/COX5B/NDUFB9/PSMB5/NDUFB7/ALYREF/VDAC1/NDUFS2/NDUFV1/DNAH17/MAPK14/NDUFB2/NDUFA12/NDUFS8/PSMB6/SEC13/NRBF2/CAT/BAD/WDR41/NDUFA1/ATP5PF/ANG/NDUFA5/NDUFS6/MAP1LC3B/PSMC5/EIF2S1/ATP5PO/NUP37/NDUFS7/NUP153/NDUFC1/CHMP2B/FIG4/PSMD4/PSMD12/SPG11/PIK3C3/CCS/TUBA1A/NDUFB10/RAB8A/PSMD2/COX7A1/VAPB/NDUFV2/ATP5F1A/MAP2K6/BAX/SOD1/NUP210L/PSMA4/NDUFA2/ANXA11/BECN1/NDUFA9/PSMB2/NUP133/COX6A1/ANXA7/NUP107/COX8A/ERN1/ATP5MC1/PSMD14/HNRNPA1L3/UQCRHL/NUP88/SLC1A2/PSMD1/NRG1/TUBB6/DNAH1/TRAF2/GPX7/UQCR11/ALS2/DNAL4/PIK3R4/DNAH14/DNAH12/NUP35	6.51265700224078
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	130/2494	308/9376	1.58676928524563	GPX1/SLC25A5/COX7C/NDUFB5/AMBRA1/COX4I1/NDUFB1/ATP5F1E/MAPK8/CREB1/RCOR1/NDUFA4/UQCRB/MAP3K5/COX7A2/SLC25A6/UQCRFS1/NRF1/UQCRH/COX7A2L/POLR2L/VDAC2/GNAQ/ATP5MC2/PPARG/PLCB1/COX6C/NDUFAB1/DCTN3/CLTA/PSMD8/NDUFB6/WIPI1/COX5A/HIP1/COX6B1/NDUFS4/CREB5/PSMB7/ATP5PB/VDAC3/ACTR10/ATP5MC3/DNAI2/COX7B/PSMA5/UQCR10/UQCRC2/POLR2G/IFT57/DCTN2/PSMB1/ATP5F1D/CREBBP/ITPR1/POLR2I/DCTN4/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/TAF4B/ATP5F1C/NDUFS5/COX5B/NDUFB9/PSMB5/NDUFB7/VDAC1/NDUFS2/NDUFV1/DNAH17/TBPL1/NDUFB2/NDUFA12/NDUFS8/PSMB6/NRBF2/AP2S1/NDUFA1/ATP5PF/NDUFA5/NDUFS6/PSMC5/ATP5PO/NDUFS7/NDUFC1/PSMD4/PSMD12/PIK3C3/TUBA1A/NDUFB10/PSMD2/SIN3A/MAPK10/COX7A1/NDUFV2/ATP5F1A/BAX/SOD1/PSMA4/NDUFA2/BECN1/NDUFA9/PSMB2/COX6A1/COX8A/ERN1/ATP5MC1/PSMD14/UQCRHL/CLTB/SLC1A2/PSMD1/TUBB6/DNAH1/TBP/TRAF2/GPX7/UQCR11/DNAL4/PIK3R4/DNAH14/DNAH12/PLCB4	6.30323506607375
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	71/2494	142/9376	1.87971130713713	RPS27A/UBE2E2/UBA52/COP1/PRKN/UBE2R2/PIAS1/UBE2E1/ELOB/FBXW11/CUL3/UBE2B/UBE2Q1/SMURF2/BIRC6/CBLB/UBE2D2/UBE2E3/RBX1/HERC1/CUL1/UBE2H/FBXW7/BTRC/WWP2/CDC26/ERCC8/ANAPC16/SAE1/UBE2L6/CUL2/UBE2M/CDC27/UBE2G1/UBE2K/RNF7/UBR5/UBE4B/FANCL/HERC4/UBA2/CUL4A/DDB2/UBA3/BRCA1/UBE2Q2/CBL/HUWE1/ANAPC11/STUB1/NEDD4/SIAH1/CUL5/ANAPC15/VHL/ELOC/FBXO4/UBE2O/NEDD4L/UBE2D1/MDM2/UBE2J1/ANAPC10/UBE2N/SMURF1/TRIM37/FBXW8/RHOBTB1/MID1/KLHL13/TRIM32	6.35866492092723
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	185/2494	480/9376	1.44894413258487	GPX1/RPS27A/UBA52/C9orf72/SLC25A5/COX7C/PRKN/NDUFB5/AMBRA1/COX4I1/RAB1A/NDUFB1/ATP5F1E/MAPK8/NDUFA4/UQCRB/TANK/PARK7/MAP3K5/ATXN1/COX7A2/SLC25A6/UQCRFS1/WNT2B/UQCRH/CAMK2D/EIF2AK3/COX7A2L/TPTEP2-CSNK1E/VDAC2/CTNNB1/GNAQ/ATP5MC2/BID/PLCB1/ATF6/COX6C/NDUFAB1/DCTN3/PSMD8/PPP3CA/PPP3CC/NDUFB6/GSK3B/MCU/WIPI1/COX5A/HIP1/MAP2K1/COX6B1/NDUFS4/PRKCB/SNCA/DKK1/PSMB7/ATP5PB/VDAC3/ACTR10/ATP5MC3/UBE2L6/DNAI2/COX7B/PSMA5/UQCR10/ATXN2/UBE2G1/UQCRC2/NFKB1/BRAF/RAC1/PSEN1/BCL2/IFT57/DCTN2/PSMB1/PPP3CB/ATP5F1D/ITPR1/CALM2/DCTN4/PRKCA/ATXN3/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/ATP5F1C/NDUFS5/TBK1/COX5B/NDUFB9/PSMB5/NDUFB7/VDAC1/NDUFS2/NDUFV1/DNAH17/MAPK14/NDUFB2/NDUFA12/NDUFS8/PSMB6/NRBF2/CAT/BAD/WDR41/NDUFA1/ATP5PF/NDUFA5/NDUFS6/CSNK2A1/MFN1/MAP1LC3B/PSMC5/EIF2S1/ATP5PO/NDUFS7/NDUFC1/CHMP2B/FIG4/PSMD4/PSMD12/SPG11/KRAS/PIK3C3/CCS/TUBA1A/NDUFB10/RAB8A/PSMD2/MAPK10/COX7A1/VAPB/RYR1/NDUFV2/ATP5F1A/MAP2K6/BAX/CSNK1A1/SOD1/SNCAIP/MAPK1/PSMA4/NDUFA2/BECN1/NDUFA9/PSMB2/COX6A1/COX8A/UBE2J1/ERN1/ATP5MC1/PSMD14/UQCRHL/FAS/FRAT2/CACNA1D/PSMD1/TUBB6/ITPR2/PRKCG/FRAT1/DNAH1/HTRA2/SPTBN2/CHRNA7/CYBB/CALM3/TRAF2/GPX7/UQCR11/ALS2/DNAL4/CALM1/PIK3R4/DNAH14/DNAH12/FZD6/WNT2/PLCB4	6.07843896461001
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	73/2494	157/9376	1.74801178880268	COX7C/NDUFB5/COX4I1/NDUFB1/MAPK8/NDUFA4/UQCRB/MAP3K5/COX7A2/UQCRFS1/UQCRH/EIF2AK3/COX7A2L/PPARG/BID/COX6C/NDUFAB1/NDUFB6/GSK3B/COX5A/COX6B1/NDUFS4/FOS/COX7B/UQCR10/UQCRC2/NFKB1/RAC1/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/NDUFS5/COX5B/NDUFB9/NDUFB7/NDUFS2/NDUFV1/MAPK14/NDUFB2/NDUFA12/TGFB1/NDUFS8/PIK3CB/NDUFA1/NDUFA5/NDUFS6/INSR/EIF2S1/NDUFS7/NDUFC1/NDUFB10/ADIPOR1/MAPK10/COX7A1/NDUFV2/BAX/NDUFA2/NDUFA9/COX6A1/COX8A/PIK3CA/LEPR/ERN1/PPARA/UQCRHL/FAS/PIK3R1/TRAF2/UQCR11	5.68974613946663
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	105/2494	250/9376	1.57895749799519	RAB11A/ARF5/ARPC2/ASAP1/RAB7A/RAB31/ARPC3/SMAP2/SMAD3/HSPA8/SNX6/SMURF2/GBF1/SNX2/CLTA/CBLB/SNF8/SH3KBP1/EPS15/CYTH3/ARF4/RAB4A/IQSEC1/CHMP4B/CAPZA2/PSD3/VPS29/GRK3/CHMP5/MVB12A/WASHC3/ACAP2/VPS26A/SNX4/RABEP1/RAB10/ARPC1A/TSG101/RNF41/CYTH1/GRK5/DNM3/PSD/SRC/RAB22A/WASHC2C/ARRB1/IGF1R/SMAP1/PIP5K1B/IL2RG/VPS35/VPS25/ARFGEF1/ARFGEF2/PDCD6IP/ACTR3/WASL/AP2S1/VTA1/SMAD2/CBL/NEDD4/CHMP2B/SNX3/RUFY2/CAV1/RAB8A/ARPC5L/STAM/ARPC4/ARAP2/CHMP6/MVB12B/WIPF3/SNX32/VPS45/STAM2/WASHC2A/VPS37A/NEDD4L/MDM2/CAPZA1/EPS15L1/TGFBR2/CLTB/SNX12/SMURF1/CHMP2A/CAPZB/WIPF1/CAV2/VPS37C/PARD6A/ARPC5/RNF103-CHMP3/AGAP1/RAB11FIP1/ASAP2/ACTR3B/IL2RB/ACTR3C/FOLR1/ARAP3/PDGFRA	5.58538331752808
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	104/2494	253/9376	1.54537530389139	H3-3A/H3-3B/U2AF1/RPS27A/UBA52/ELMO1/PRKCE/ARPC2/MAPK8/ATG5/ARPC3/MALT1/FBXW11/ACTG1/RIPK1/RPTOR/PLCB1/FOXO1/UBE2D2/TAB2/FOXO3/MYL12B/RBX1/GSK3B/WIPI1/CUL1/CYTH3/MYL12A/BTRC/SEPTIN6/RPS6KA5/NFKB1/PYCARD/RAC1/WASF2/BCL2/FNBP1/SEPTIN7/ITPR1/ARPC1A/TBK1/CYTH1/UBE2V2/TLR5/RPS6KB2/VDAC1/SRC/RIPK2/SEPTIN11/MAPK14/CASP4/RRAGD/CALCOCO2/ACTR3/WASL/VCL/PIK3CB/MAP1LC3B/IL18/DOCK1/TRADD/PIK3C3/RRAGA/ARPC5L/ARPC4/CAST/MAPK10/PRKCQ/RBCK1/BAX/MAPK1/GLMN/BECN1/TLN2/UBE2D1/MDM2/PIK3CA/TNIP1/U2AF1L4/SHARPIN/SEPTIN9/UBE2N/PIK3R1/PTK2/NOD1/ITPR2/ARPC5/HCLS1/NLRC4/MYL9/MYL11/IL1R1/ACTR3B/TRAF2/CD44/TRAF5/DIAPH1/PIK3R4/H3C1/MYL5/NLRP3/ACTR3C/FNBP1L/PLCB4	5.29374990370851
NA	NA	hsa04517	IgSF CAM signaling	118/2494	299/9376	1.48365173406141	ARPC2/CD48/MAPK8/MBP/ARPC3/ERC1/RAP1B/JAML/LCP2/CD86/ACTG1/LYN/CTNNB1/RAP1A/RASA1/MYL6/PAK1/CASK/FOXO1/MYL12B/VAV3/NCK1/GSK3B/ROBO1/MYL12A/MAP2K1/PRKCB/FYN/TRIO/EPB41L3/ABL1/SRGAP1/RAC1/IL1RAPL2/PRKCA/ARPC1A/ITGA4/NPHS1/CRTAM/SRC/DYNLL1/DOK2/MAPK14/ANK2/EPB41L2/RDX/ACTR3/LY9/WASL/RAPGEF2/VCL/PIK3CB/VAV1/ICAM2/NCAM1/CADM3/TUBA1A/UNC5B/ARPC5L/VAV2/ARPC4/CD96/MAPK10/MTSS1/MSN/PRKCQ/PALS2/CD2AP/MAPK1/SLIT2/PIK3CA/SRGAP2/ANK3/CD80/LMO7/GRIP1/CD244/KCNQ3/ICAM3/PIK3R1/CD226/PTK2/TUBB6/PTPRS/LCK/MYH10/PARD6A/ARPC5/PRKCG/MYH14/SPTBN2/MYL6B/SH2D1B/MYL9/IL1RAPL1/IQGAP1/SPTBN4/NTRK3/PMP22/NLGN3/ACTR3B/IL1RAP/CADM1/ROBO2/CD2/NCAM2/MAP2/SLAMF7/SORBS1/MYLK4/CNTNAP2/MAGI2/SH2D1A/PLXNA4/SLAMF6/ACTR3C/PTPRD/KIRREL2	5.11650855096886
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	144/2494	388/9376	1.39524963003993	SLC25A5/COX7C/NDUFB5/AMBRA1/COX4I1/NDUFB1/ATP5F1E/MAPK8/NDUFA4/UQCRB/MAP3K5/COX7A2/SLC25A6/UQCRFS1/WNT2B/UQCRH/EIF2AK3/COX7A2L/TPTEP2-CSNK1E/VDAC2/CTNNB1/GNAQ/ATP5MC2/BID/PLCB1/ATF6/COX6C/NDUFAB1/PSMD8/SLC39A11/PPP3CA/PPP3CC/NDUFB6/GSK3B/MCU/WIPI1/COX5A/MAP2K1/COX6B1/NDUFS4/SNCA/DKK1/PSMB7/ATP5PB/VDAC3/ATP5MC3/COX7B/PSMA5/UQCR10/UQCRC2/NFKB1/BRAF/PSEN1/PSMB1/PPP3CB/ATP5F1D/ITPR1/CALM2/PSMA7/NDUFB11/NDUFB4/CASP9/NDUFA10/NDUFA8/NDUFB3/SDHB/SDHC/RTN4/ATP5F1C/NDUFS5/COX5B/NDUFB9/PSMB5/NDUFB7/VDAC1/NDUFS2/APH1B/NDUFV1/NDUFB2/NDUFA12/SLC39A9/NDUFS8/PSMB6/NRBF2/PIK3CB/BAD/NDUFA1/ATP5PF/NDUFA5/NDUFS6/CSNK2A1/INSR/PSMC5/EIF2S1/ATP5PO/NDUFS7/NDUFC1/PSMD4/PSMD12/KRAS/PIK3C3/TUBA1A/NDUFB10/PSMD2/MAPK10/COX7A1/NDUFV2/ATP5F1A/CSNK1A1/NAE1/MAPK1/PSMA4/NDUFA2/BECN1/NDUFA9/PSMB2/COX6A1/COX8A/PIK3CA/ERN1/ATP5MC1/PSMD14/UQCRHL/FAS/FRAT2/CACNA1D/PSMD1/PIK3R1/ADAM17/TUBB6/ITPR2/FRAT1/CHRNA7/BACE1/CYBB/CALM3/TRAF2/LPL/UQCR11/CALM1/PIK3R4/FZD6/WNT2/PLCB4	4.78665725924506
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	61/2494	138/9376	1.66177376428065	ELMO1/ARPC2/MAPK8/ARPC3/LCP2/ACTG1/NFATC3/GNAQ/MAP2K4/TAB2/VAV3/GSK3B/RPS6KA3/MAP2K1/FOS/NFKB1/PKN2/PYCARD/RAC1/WASF2/ARPC1A/ITGA4/TBK1/IRAK4/RAC2/SRC/MAPK14/PIP5K1B/ACTR3/RPS6KA2/WASL/PIK3CB/NFATC2/VAV1/IL18/DOCK1/ARPC5L/VAV2/ARPC4/MAPK10/ARHGEF7/NFATC1/MAP2K6/WIPF3/MAPK1/PIK3CA/SKAP2/PTK2B/PIK3R1/PTK2/WIPF1/LCK/ARPC5/FYB1/NLRC4/ACTR3B/TRAF2/CD8A/NLRP3/ACTR3C/MEFV	4.7145108399075
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	39/2494	78/9376	1.87971130713713	ELMO1/ARPC2/ARPC3/ACTG1/CTNNB1/CLTA/SEPTIN6/RAC1/WASF2/ARPC1A/DNM3/GAB1/SRC/SEPTIN11/MAD2L2/ACTR3/WASL/VCL/PIK3CB/CBL/DOCK1/CAV1/ARPC5L/ARHGAP10/ARPC4/CD2AP/PIK3CA/SEPTIN9/CLTB/PIK3R1/CTNNA3/PTK2/CAV2/ARPC5/SHC3/SEPTIN1/HCLS1/ACTR3B/ACTR3C	4.69644491846949
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	72/2494	174/9376	1.55562315073418	MARCHF6/PRKN/MAPK8/TMEM258/MAP3K5/HSPA8/EIF2AK3/DNAJC1/SEC61G/ATF6/SEC24B/UBE2D2/RBX1/CUL1/OSTC/DAD1/SSR3/NGLY1/DNAJC5B/BAG1/UBXN1/SSR4/UBE2G1/DDOST/SIL1/MAN1A1/BCL2/SSR2/ATXN3/UBE4B/UFD1/UBXN2A/DNAJC5/SEC31A/PLAA/EDEM2/DNAJA2/SEC13/ERP29/DNAJB12/CRYAB/EIF2S1/HERPUD1/STUB1/SAR1B/PDIA6/SEC63/LMAN1/DERL2/MAPK10/DNAJC3/MAN1C1/BAX/MAN1A2/MAGT1/UBE2D1/UBE2J1/ERN1/SEC24D/RNF185/UGGT2/AMFR/ERLEC1/DUS4L-BCAP29/SVIP/SEC61B/STT3B/UBXN8/RPN2/TRAF2/SEC62/MBTPS2	4.45338632469825
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	91/2494	232/9376	1.47460111163344	CYRIB/CYRIA/ARPC2/TMSB4X/SSH2/ARPC3/GNA12/BRK1/ACTG1/PIP4K2A/PAK1/DIAPH2/MYL12B/VAV3/SOS1/MYL12A/MAP2K1/PPP1CA/LPAR1/PPP1R12B/C7/ITGAE/BRAF/RAC1/WASF2/PPP1R12A/LIMK2/TIAM1/GNA13/PDGFC/PPP1CC/ARPC1A/RRAS/ITGA4/RAC2/SRC/GSN/PIP5K1B/RGCC/SOS2/ITGA6/RDX/ACTR3/WASL/VCL/PIK3CB/VAV1/C5/DOCK1/IQGAP2/CFL1/KRAS/CYFIP2/SSH1/ARPC5L/VAV2/ARPC4/ARHGEF7/MSN/FGD3/MAPK1/PIK3CA/CXCL12/ITGA9/PIK3R1/PTK2/MYH10/ARPC5/RRAS2/MYH14/PDGFD/MYL9/ITGAD/MYL11/PDGFA/IQGAP1/ACTR3B/ITGB4/ITGAV/ITGB5/ITGB8/DIAPH1/FGF7/MYLK4/MYL5/SCIN/ITGB6/C9/ACTR3C/CFL2/PDGFRA	4.4063720466553
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	48/2494	105/9376	1.7185931950968	RPS27A/UBA52/TOMM7/MARCHF5/PRKN/AMBRA1/RAB7A/ARIH1/MAPK8/TOMM20/EIF2AK3/GABARAPL2/SMURF2/FOXO3/MITF/FIS1/PHB2/TBC1D15/RHOT1/OPA1/MTX2/RRAS/TBK1/SRC/CALCOCO2/BNIP3L/FUNDC1/CSNK2A1/MFN1/MAP1LC3B/HUWE1/EIF2S1/BCL2L13/SIAH1/KRAS/MAPK10/BECN1/AMFR/SMURF1/TAX1BP1/RRAS2/CCZ1B/USP30/USP15/TRAF2/CITED2/HIF1A/ATG9B	4.45749626401684
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	61/2494	144/9376	1.59253319076896	SLC25A5/AMBRA1/MAPK8/MAP3K5/ATXN1/SLC25A6/VDAC2/GNAQ/PLCB1/PSMD8/ATXN10/MCU/WIPI1/PRKCB/PSMB7/VDAC3/PSMA5/ATXN2/OPA1/PUM2/PSMB1/ITPR1/PRKCA/ATXN3/PSMA7/PSMB5/GTF2B/VDAC1/PUM1/TBPL1/PSMB6/BEAN1/NRBF2/PIK3CB/RORA/PSMC5/PSMD4/PSMD12/PIK3C3/PSMD2/MAPK10/RYR1/PSMA4/BECN1/PSMB2/PIK3CA/ERN1/PSMD14/DAB1/NFYA/RBPJ/PSMD1/KCNC3/PIK3R1/ITPR2/PRKCG/SPTBN2/TBP/TRAF2/PIK3R4/PLCB4	4.31342805950252
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	45/2494	98/9376	1.72626548614634	GAB2/PLA2G6/PRKCE/ARPC2/ASAP1/ARPC3/PLA2G4C/LYN/PAK1/VAV3/MAP2K1/PRKCB/PLA2G4A/RAC1/WASF2/LIMK2/FCGR1A/PRKCA/ARPC1A/RPS6KB2/RAC2/SYK/GSN/PIP5K1B/PLPP1/ACTR3/PIK3CB/VAV1/DOCK1/CFL1/ARPC5L/VAV2/ARPC4/HCK/MAPK1/PIK3CA/PIK3R1/ARPC5/PRKCG/ASAP2/MYO10/ACTR3B/SCIN/ACTR3C/CFL2	4.35068648126192
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	84/2494	214/9376	1.47566121307962	MAPK8/GNG7/ELOB/FBXW11/RIPK1/NFATC3/GNAQ/BID/PAK1/TAB2/PPP3CA/RBX1/PPP3CC/CUL1/MAP2K1/PRKCB/BTRC/FOS/AP1S2/NFKB1/RNF7/GNAI3/RAC1/BCL2/APOBEC3G/LIMK2/PPP3CB/ITPR1/CALM2/GNG2/PRKCA/CASP9/ATR/TLR2/TBK1/IRAK4/RPS6KB2/RAC2/CUL4A/MAPK14/GNB1/CD247/GNG5/PIK3CB/BAD/NFATC2/CD3D/TRADD/CUL5/CFL1/KRAS/MAPK10/AP1G1/NFATC1/MAP2K6/BAX/CD3E/AP1S1/ELOC/DCAF1/MAPK1/PIK3CA/FAS/CD3G/PTK2B/PIK3R1/PTK2/TRIM5/ITPR2/APOBEC3B/PRKCG/APOBEC3A/APOBEC3F/GNGT2/GNAI1/CCNB2/CALM3/TRAF2/TRAF5/APOBEC3H/CALM1/GNG4/CFL2/GNG11	4.23726875558685
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	54/2494	125/9376	1.62407056936648	GAB2/PRKCE/MAPK8/MAP3K5/GNA12/CERS6/GNAQ/BID/PLCB1/SGMS1/MAP2K1/PRKCB/FYN/PPP2R5C/NFKB1/GNAI3/RAC1/BCL2/GNA13/PRKCA/PPP2R3C/RAC2/NSMAF/MAPK14/PPP2R5A/ORMDL1/PIK3CB/CERS5/TRADD/PPP2R5E/SPTLC1/KRAS/CERS4/PPP2R2D/PPP2R2A/MAPK10/SPTLC2/BAX/MAPK1/S1PR4/SGMS2/PIK3CA/SPTLC3/FCER1G/PPP2R3A/PIK3R1/PPP2R2B/PRKCG/GNAI1/TRAF2/ACER2/S1PR5/FCER1A/PLCB4	4.22834968927408
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	26/2494	48/9376	2.03635391606522	PCCA/MCCC1/HIBCH/AUH/ACAT2/ALDH9A1/HIBADH/BCKDHB/ACAA2/IVD/DLD/ACADM/HADH/ECHS1/HADHB/HADHA/HMGCL/ACAA1/PCCB/MCEE/BCAT2/ALDH2/ABAT/MMUT/OXCT1/ACADSB	4.33322231929995
Organismal Systems	Immune system	hsa04611	Platelet activation	54/2494	126/9376	1.61118112040325	PIK3R5/PLA2G4C/RAP1B/LCP2/ADCY3/ACTG1/LYN/GNAQ/RAP1A/PLCB1/TBXAS1/MYL12B/MYL12A/PPP1CA/STIM1/FYN/VAMP8/PLA2G4A/GNAI3/APBB1IP/PPP1R12A/GUCY1A1/GNA13/ITPR1/PPP1CC/COL3A1/PRKACB/SYK/SRC/MAPK14/BTK/PIK3CB/ORAI1/ADCY9/MAPK1/TLN2/RASGRP1/PIK3CA/SNAP23/P2RY12/FCER1G/PRKG1/PIK3R1/PIK3R6/RASGRP2/ITPR2/P2RX1/VWF/GUCY1B1/COL1A1/GNAI1/COL1A2/MYLK4/PLCB4	4.15777386561785
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	42/2494	93/9376	1.69780376128515	FER/RAP1B/PTPRM/SMAD3/ACTG1/PTPRJ/CTNNB1/NLK/RAP1A/SMURF2/FARP2/MYL12B/TCF7L2/MYL12A/FYN/PDCD10/RAC1/WASF2/PTPN1/CREBBP/ACP1/RAC2/SRC/IGF1R/WASL/VCL/CSNK2A1/INSR/TCF7/CCM2/MAPK1/TGFBR2/LMO7/YES1/SMURF1/CTNNA3/MYL9/MYL11/IQGAP1/SORBS1/MYL5/LEF1	4.07105653712792
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	52/2494	122/9376	1.60237685198575	MAPK8/LCP2/MALT1/NFATC3/PAK1/CBLB/PPP3CA/VAV3/NCK1/PPP3CC/GSK3B/SOS1/MAP2K1/FYN/PPP2R5C/FOS/DLG1/NFKB1/PPP3CB/PPP2R3C/MAPK14/PPP2R5A/SOS2/CD247/TEC1/PIK3CB/NFATC2/VAV1/CD3D/PPP2R5E/KRAS/VAV2/PPP2R2D/PPP2R2A/CARD11/MAPK10/NFATC1/PRKCQ/CD3E/MAPK1/RASGRP1/PIK3CA/ITK/MAP3K14/CD3G/GRAP2/PPP2R3A/PIK3R1/PPP2R2B/LCK/CD8A/ICOS	4.03143786820039
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	54/2494	128/9376	1.58600641539695	ADSS2/FHIT/ADK/NUDT2/PDE8A/PDE4D/ADCY3/PAPSS2/PDE4B/NT5C2/NME7/PDE3B/PDE7A/ADA/APRT/PDE4A/ENTPD1/NME3/HDDC2/PDE7B/GMPS/DGUOK/GUCY1A1/NME4/DCK/PDE6D/NUDT5/HPRT1/PDE5A/RRM2B/PRPS2/ITPA/ADCY9/NTPCR/PGM2/RRM1/AK3/NUDT16/PDE2A/GUK1/ADSS1/PGM1/ENPP1/HDDC3/PDE1B/GUCY1B1/PDE3A/PDE1C/ADCY10/AK5/AK9/NT5E/PDE6G/ADPRM	4.0184629958332
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	43/2494	98/9376	1.64954257565095	BPNT2/INPP5A/IPMK/PLCB1/PIP4K2A/INPP4A/SYNJ1/ITPKB/PI4K2B/MTMR3/PRKCB/MTMR14/ITPR1/CALM2/MTM1/PRKCA/IMPA2/PI4KA/PIP5K1B/PIP4P2/PIK3CB/MTMR1/PIK3C3/INPP5F/MTMR6/PPIP5K2/MTMR2/MTMR8/PIK3CA/IP6K2/CDIPT/INPP5B/DGKH/INPP4B/PIK3R1/ITPR2/PRKCG/CDS2/CALM3/CALM1/PPIP5K1/CDS1/PLCB4	3.89107861628331
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	92/2494	248/9376	1.39462451819852	RPS3/ELMO1/EXOC4/ARPC2/RAB7A/LY96/MAPK8/ARPC3/SNX9/BRK1/ACTG1/RIPK1/CTNNB1/MAP2K4/PAK1/KPNA3/DCTN3/TAB2/MYL12B/TCF7L2/CYTH3/MYL12A/MAP2K1/ACTR10/RAB9A/FOS/ARL8B/RHOH/NFKB1/PYCARD/RAC1/BCL2/EXOC2/DCTN2/TXN2/DCTN4/ARPC1A/RRAS/TLR2/CYTH1/IRAK4/TNFSF10/TLR5/DYNLL1/RIPK2/TNFRSF10B/MAPK14/CASP4/VPS41/STX10/ACTR3/WASL/TIRAP/PIK3CB/IL18/ABI1/TRADD/DYNLT1/TCF7/CYFIP2/PIK3C3/TUBA1A/ARPC5L/DYNC1LI1/KPNA1/ACBD3/ARPC4/MAPK10/MAP2K6/BAX/MAPK1/PIK3CA/RALA/NOD1/DYNC2LI1/TUBB6/ARPC5/NLRC4/MYL9/MYL11/CASP5/ACTR3B/KPNA4/DYNC2H1/TRAF2/AHNAK2/MYL5/DYNC1I1/NLRP3/ACTR3C/MYO6/LEF1	3.79139137697241
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	18/2494	31/9376	2.18289055022376	IMMP2L/SEC11A/SPCS1/SEC61G/SEC11C/SRP9/SRP14/SRP72/IMMP1L/SEC63/OXA1L/GET3/SPCS2/GET1/SEC61B/UBL4A/SRPRB/SEC62	3.97111336332379
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	77/2494	203/9376	1.42598788817299	MAPK8/RAP1B/ACTG1/CTNNB1/RAP1A/PAK1/MYL12B/VAV3/GSK3B/SOS1/MYL12A/MAP2K1/PPP1CA/PRKCB/FYN/PPP1R12B/RAPGEF1/BRAF/RAC1/PPP1R12A/BCL2/PDGFC/PPP1CC/PRKCA/ITGA4/RAC2/SRC/IGF1R/PIP5K1B/LAMA2/SOS2/PARVB/ITGA6/VCL/PIK3CB/BAD/VAV1/VEGFB/DOCK1/COL6A2/CAV1/VAV2/MAPK10/COL6A1/MAPK1/TLN2/CCND3/PIK3CA/IGF1/ITGA9/PIK3R1/PTK2/CAV2/PRKCG/SHC3/THBS1/PDGFD/MYL9/ELK1/MYL11/PDGFA/VWF/COL1A1/COL6A3/ITGB4/ITGAV/ITGB5/ITGB8/DIAPH1/COL1A2/MYLK4/MYL5/ITGB6/LAMA1/EMP2/PDGFRA/LAMB3	3.6937381257898
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	77/2494	204/9376	1.41899775146626	LUM/RPS6/DCN/IGF2/WNT2B/CAMK2D/ACTG1/CTNNB1/ESR1/PAK1/VAV3/SOS1/PDCD4/MAP2K1/PPP1CA/PRKCB/FRS2/PPP1R12B/BRAF/RAC1/PPP1R12A/TIAM1/ITPR1/PPP1CC/PRKCA/RRAS/TLR2/PRKACB/GAB1/RPS6KB2/EIF4B/SRC/IGF1R/MAPK14/ANK2/SOS2/TGFB1/RDX/PIK3CB/VAV1/SMAD2/CBL/KRAS/CAV1/VAV2/MSN/MAPK1/HPSE/NUDT16L1/MDM2/SDC2/PIK3CA/ANK3/FAS/IGF1/PIK3R1/MMP2/PTK2/CAV2/ITPR2/PRKCG/RRAS2/THBS1/HCLS1/ELK1/IQGAP1/COL1A1/CD63/ITGAV/ITGB5/CD44/HIF1A/COL1A2/FZD6/TGFB2/TFAP4/WNT2	3.64226282889564
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	61/2494	157/9376	1.46066738516388	SLC25A5/SLC25A6/SMAD3/FBXW11/NFATC3/VDAC2/FOXO1/FOXO3/PPP3CA/PPP3CC/MCU/MAP2K1/PPP1CA/BTRC/VDAC3/NFKB1/RHEB/PPP3CB/ITPR1/CALM2/PPP1CC/RRAS/ATR/VDAC1/MAPK14/TGFB1/RASSF5/ZFP36L2/PIK3CB/NFATC2/HIPK3/LIN52/SMAD2/CDK6/KRAS/CHEK2/NFATC1/MAP2K6/MAPK1/CCND3/MDM2/PIK3CA/ETS1/TGFBR2/CACNA1D/RAD1/PIK3R1/RBL1/ITPR2/TRPV4/RRAS2/MAPKAPK2/RAD9B/CCNB2/CALM3/HIPK4/CALM1/GADD45B/TGFB2/TRAF3IP2/CDKN2A	3.50406305829735
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	18/2494	33/9376	2.0505941532405	VTI1A/STX8/STX5/STX18/VAMP8/VAMP5/VAMP3/BET1/STX17/GOSR1/BET1L/SNAP29/VTI1B/STX11/STX7/USE1/SNAP23/BNIP1	3.63936239849683
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	63/2494	169/9376	1.40144156626792	RPS27A/ATG7/UBA52/C9orf72/AMBRA1/RAB1A/UVRAG/RAB7A/MAPK8/IGBP1/ATG5/TANK/EIF2AK3/GABARAPL2/ATG10/RPTOR/BIRC6/WIPI1/MTMR3/MAP2K1/WDFY3/VAMP8/DAPK1/RHEB/MTMR14/BCL2/ITPR1/RRAS/PRKACB/TBK1/RPS6KB2/STX17/IGF1R/VPS41/RRAGD/SNAP29/CALCOCO2/NRBF2/DEPTOR/PIK3CB/ATG3/BAD/WDR41/MAP1LC3B/EIF2S1/KRAS/PIK3C3/RRAGA/RAB8A/MAPK10/WDR45/PRKCQ/MAPK1/BECN1/STX7/PIK3CA/ERN1/PIK3R1/TAX1BP1/RRAS2/HIF1A/PIK3R4/ATG9B	3.17017435017045
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	34/2494	80/9376	1.59775461106656	RPS6/FOXO3/GSK3B/SOS1/MAP2K1/PRKCB/NF1/BRAF/BCL2/PDGFC/PRKCA/JAK2/GAB1/RPS6KB2/SRC/IGF1R/SOS2/EIF4E2/PIK3CB/BAD/JAK1/KRAS/AXL/BAX/MAPK1/PIK3CA/IGF1/PIK3R1/NRG1/PRKCG/SHC3/PDGFD/PDGFA/PDGFRA	3.23218640728426
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	47/2494	120/9376	1.47244052392408	MAPK8/MAP3K5/RAP1B/MAP2K5/CAMK2D/IRAK3/IRAK2/RAP1A/FOXO3/GSK3B/SOS1/RPS6KA3/MAP2K1/FRS2/RPS6KA5/RAPGEF1/NFKB1/BRAF/ABL1/RAC1/PSEN1/BCL2/CALM2/IRAK4/GAB1/RIPK2/SH2B3/MAPK14/SOS2/RPS6KA2/PIK3CB/BAD/KRAS/MAPK10/BAX/MAPK1/PIK3CA/CAMK4/ARHGDIB/PIK3R1/SHC3/MAPKAPK2/NTRK3/MATK/CALM3/SH2B2/CALM1	3.13546979289425
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	30/2494	69/9376	1.63453157142359	GAB2/MAPK8/PLA2G4C/LCP2/LYN/MAP2K4/VAV3/SOS1/MAP2K1/FYN/PLA2G4A/RAC1/PRKCA/RAC2/SYK/MAPK14/SOS2/BTK/PIK3CB/VAV1/KRAS/VAV2/MAPK10/MAP2K6/MAPK1/PIK3CA/FCER1G/PIK3R1/ALOX5AP/FCER1A	3.18456012274385
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	36/2494	87/9376	1.55562315073418	MAPK8/SMAD3/CTNNB1/GSK3B/SOS1/TCF7L2/MAP2K1/FOS/BRAF/RAC1/BCL2/APPL1/CASP9/POLK/RPS6KB2/RAC2/DDB2/SOS2/TGFB1/PIK3CB/BAD/SMAD2/TCF7/KRAS/MAPK10/BAX/MAPK1/PIK3CA/RALA/MSH2/MLH1/TGFBR2/PIK3R1/GADD45B/TGFB2/LEF1	3.13423824971301
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	26/2494	59/9376	1.6566947113751	DPYD/NUDT2/NT5C2/NME7/DUT/ENTPD1/NME3/ASMTL/HDDC2/NME4/DTYMK/CMPK1/DCK/CDA/DCTPP1/RRM2B/NT5C3A/RRM1/CTPS2/CDADC1/ENPP1/UPB1/UMPS/DPYS/AK9/NT5E	3.04598671935599
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	55/2494	149/9376	1.38770633412808	NDUFB5/NDUFB1/MAPK8/GNG7/NDUFA4/ADCY3/GNAQ/PLCB1/NDUFAB1/NDUFB6/NDUFS4/PRKCB/GNAI3/ITPR1/GNG2/PRKCA/NDUFB11/NDUFB4/NDUFA10/NDUFA8/NDUFB3/PRKACB/NDUFS5/NDUFB9/NDUFB7/NDUFS2/NDUFV1/MAPK14/NDUFB2/GNB1/NDUFA12/NDUFS8/GNG5/NDUFA1/NDUFA5/NDUFS6/NDUFS7/NDUFC1/ABHD6/NDUFB10/ADCY9/MAPK10/NDUFV2/MAPK1/NDUFA2/NDUFA9/CACNA1D/ITPR2/PRKCG/KCNJ6/GNGT2/GNAI1/GNG4/GNG11/PLCB4	2.87172136238143
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	86/2494	250/9376	1.29324137931034	CTSH/SUMF1/RAB7A/ARSG/SLC17A5/MANBA/WDR7/OSBPL3/AP3B1/DTNBP1/RPTOR/CLTA/CTBS/MITF/OSBPL1A/VAMP8/LAMTOR1/AP1S2/VPS29/ATP6V1D/ARL8B/ATP6V1G1/ATP6V0E1/ARSB/LAMTOR4/CTSW/VPS26A/BORCS7/GLA/SNAPIN/CTSS/AP3S1/DMXL1/SLC36A4/GUSB/STX17/GPR155/VPS41/RRAGD/SNAP29/VPS35/BLOC1S2/CTSF/LAMTOR5/SLC38A9/DEPTOR/AP2S1/SLC29A3/CLN5/ATP6V1E1/AP4S1/FIG4/SPG11/DMXL2/LAMTOR2/HGSNAT/ROGDI/RRAGA/LITAF/FUCA2/AP1G1/BORCS8/OSBP/NPC2/AP1S1/BLOC1S4/NPC1/ATP6V0A1/ABCA5/AP5Z1/GLB1/LAPTM4A/MCOLN2/CLTB/OSBPL5/ATP6V0D1/ATP6V0B/BORCS6/CTSK/CD63/LAMP3/AP3M2/MEAK7/SLC36A3/AP3B2/LAPTM4B	2.8289909253797
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	39/2494	99/9376	1.48098466622925	PLA2G6/PRKCH/PRKCE/MAPK8/PLA2G4C/ADCY3/CAMK2D/GNAQ/PLCB1/PPP1CA/PRKCB/PLA2G4A/ITPR1/CALM2/PPP1CC/PRKCA/PRKACB/SRC/MAPK14/PIK3CB/PTGER2/HRH1/ADCY9/MAPK10/PRKCQ/MAP2K6/PIK3CA/IGF1/PIK3R1/ITPR2/TRPV4/PRKCG/ALOX12/IL1R1/IL1RAP/CALM3/CALM1/P2RY2/PLCB4	2.89615351741461
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	60/2494	166/9376	1.3588274509425	SLC25A5/PIK3R5/PRKCE/CREB1/GNA12/SLC25A6/SLC8A1/ADCY3/NFATC3/VDAC2/GNAQ/PLCB1/MEF2C/PPP3CA/PPP3CC/PDE3B/MAP2K1/PPP1CA/CREB5/VDAC3/KCNMB4/GNAI3/MEF2A/PPP1R12A/GUCY1A1/GNA13/PPP3CB/ITPR1/CALM2/PPP1CC/VDAC1/ATP2B1/BAD/NFATC2/PDE5A/INSR/ATP2B4/ADCY9/NFATC1/MAPK1/ATP1B1/PDE2A/PRKG1/CACNA1D/PIK3R6/ITPR2/CNGA1/CNGB1/MYL9/GUCY1B1/IRAG1/GNAI1/PDE3A/CALM3/NPPA/CALM1/KCNMA1/MYLK4/SLC8A2/PLCB4	2.80793090908365
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	72/2494	205/9376	1.32038257672072	H4C3/HDAC9/TRAF3/CREB1/LYN/YWHAB/SND1/GTF2A2/UBR4/CREB5/VDAC3/HDAC4/RASA2/DLG1/POLB/NFKB1/RAC1/EGR2/CREBBP/RANBP1/PRKACB/GTF2B/SYK/SRC/YWHAZ/GSN/TBPL1/STAT5B/PIK3CB/BAD/H2BC21/TRADD/CDK6/JAK1/KRAS/CDKN1B/HDAC3/H4C5/H2BC4/KAT2B/YWHAQ/BAX/MAPK1/H2BC18/CCND3/GTF2E2/MDM2/PIK3CA/H2BC12/RBPJ/ATP6V0D1/PIK3R1/YWHAH/RBL1/MAPKAPK2/H2BC15/GTF2A1/H4C8/SP100/TRAF1/H2BC6/TBP/H4C1/GTF2E1/TRAF2/TRAF5/H2BC11/CCR3/SCIN/IL6ST/CDKN2A/H2BC9	2.79199092520667
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	69/2494	196/9376	1.32347020604553	RPS27A/UBA52/PIK3R5/MAPK8/TRAF3/GNG7/CREB1/CD86/LYN/NFATC3/CTNNB1/MAP2K4/BID/PPP3CA/PPP3CC/GSK3B/TCF7L2/MAP2K1/FOS/NFKB1/RAC1/PPP3CB/CREBBP/ITPR1/CALM2/GNG2/CASP9/TBK1/JAK2/STAT1/SYK/SRC/MAPK14/GNB1/GNG5/PIK3CB/ATG3/NFATC2/MAP1LC3B/IFNGR1/TRADD/CDK6/TCF7/JAK1/KRAS/PIK3C3/MAPK10/HCK/NFATC1/MAP2K6/BAX/MAPK1/BECN1/PIK3CA/FAS/PIK3R1/PIK3R6/ITPR2/MAPKAPK2/GNGT2/CALM3/TRAF2/HIF1A/CALM1/CCR3/GNG4/IL6ST/GNG11/LEF1	2.75497402737045
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	56/2494	154/9376	1.367062768827	CAMK1D/PIK3R5/PLA2G4C/MAP2K5/ADCY3/CAMK2D/ACTG1/NFATC3/GNAQ/MYL6/PLCB1/MEF2C/PPP3CA/PPP3CC/MAP2K1/PPP1CA/PRKCB/FOS/PLA2G4A/PPP1R12B/GNAI3/CACNA2D3/PPP1R12A/GUCY1A1/PPP3CB/ITPR1/CALM2/PPP1CC/PRKCA/PRKACB/SRC/NFATC2/KRAS/ADCY9/RYR1/NFATC1/MAPK1/CAMK1/CAMK4/CD38/CACNA1D/PIK3R6/ITPR2/PRKCG/CACNB4/MYL6B/KCNJ6/MYL9/ELK1/GUCY1B1/GNAI1/CALM3/NPPA/CALM1/MYLK4/PLCB4	2.76480601961407
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	34/2494	85/9376	1.5037690457097	ADSS2/ADK/NT5C2/NME7/DUT/ADA/APRT/ENTPD1/NME3/ASMTL/HDDC2/GMPS/DGUOK/NME4/DTYMK/CMPK1/DCK/HPRT1/CDA/DCTPP1/RRM2B/ITPA/NTPCR/NT5C3A/RRM1/AK3/NUDT16/CTPS2/GUK1/ADSS1/ENPP1/AK5/AK9/NT5E	2.80857638583326
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/2494	76/9376	1.53344869792766	CAMK1D/CAMK2D/SOS1/MAP2K1/PRKCB/BRAF/CALM2/PRKCA/POLK/IGF1R/DDB2/SOS2/PIK3CB/CDK6/KRAS/BAX/MAPK1/CAMK1/MDM2/PIK3CA/CAMK4/IGF1/PIK3R1/PRKCG/SHC3/PDGFA/CALM3/CALM1/GADD45B/CDKN2A/PDGFRA	2.81082954559227
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	28/2494	67/9376	1.57110198805491	RAP1B/CAMK2D/GNAQ/RAP1A/PLCB1/PPP3CA/PPP3CC/RPS6KA3/MAP2K1/PPP1CA/PRKCB/BRAF/PPP3CB/CREBBP/ITPR1/CALM2/PPP1CC/PRKCA/PRKACB/RPS6KA2/KRAS/MAPK1/CAMK4/ITPR2/PRKCG/CALM3/CALM1/PLCB4	2.82407409326361
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	15/2494	30/9376	1.87971130713713	PIGF/PIGP/PIGH/PIGX/MPPE1/PIGL/DPM2/PGAP2/PIGN/PIGC/PIGB/PIGV/PIGA/PIGS/PIGZ	2.90512244499781
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	52/2494	142/9376	1.37668997142438	SUMO2/MAPK8/MAP3K5/MAP2K5/CYBA/ACTG1/CTNNB1/MAP2K4/MEF2C/SUMO1/FOS/MGST3/NFKB1/MGST2/DUSP1/BMPR2/RAC1/MEF2A/BCL2/TXN2/CALM2/RAC2/SRC/GSTP1/GSTT1/MAPK14/ACVR2A/PIK3CB/CAV1/MAPK10/MAP2K6/NCF2/SDC2/PIK3CA/ACVR1/PIK3R1/MMP2/PTK2/GSTM1/CAV2/BMPR1A/TRPV4/PDGFA/IL1R1/GSTO1/ITGAV/CALM3/MGST1/CALM1/KLF2/VCAM1/GSTO2	2.72276289724658
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	20/2494	44/9376	1.70882846103375	CCNH/GTF2A2/TAF12/GTF2F2/MNAT1/TAF11/GTF2H5/TAF4B/GTF2B/TBPL1/TAF2/TAF13/TAF10/GTF2F1/TAF3/GTF2E2/GTF2A1/TBP/GTF2E1/ERCC3	2.83698244825473
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	49/2494	133/9376	1.38505043683788	CD48/HCST/LCP2/TYROBP/BID/PAK1/PPP3CA/VAV3/PPP3CC/SOS1/MAP2K1/PRKCB/FYN/KLRD1/LAT2/BRAF/RAC1/GZMB/PPP3CB/PRKCA/TNFSF10/RAC2/SYK/TNFRSF10B/SOS2/CD247/PIK3CB/NFATC2/VAV1/ICAM2/IFNGR1/KRAS/PRF1/VAV2/NFATC1/MAPK1/KLRC4-KLRK1/PIK3CA/FCER1G/CD244/FAS/PTK2B/PIK3R1/LCK/PRKCG/SHC3/SH2D1B/KLRC1/SH2D1A	2.69223826749949
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	31/2494	77/9376	1.51353377977275	GAB2/SMAD3/SOS1/MAP2K1/NFKB1/BRAF/ABL1/CTBP2/POLK/DDB2/SOS2/TGFB1/STAT5B/PIK3CB/BAD/CBL/CDK6/KRAS/CDKN1B/BAX/MAPK1/MDM2/PIK3CA/TGFBR2/PIK3R1/MECOM/SHC3/RUNX1/GADD45B/TGFB2/CDKN2A	2.72378474815816
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	31/2494	78/9376	1.4941295005449	INPP5A/IPMK/PLCB1/PIP4K2A/INPP4A/SYNJ1/ITPKB/PI4K2B/MTMR3/MTMR14/MTM1/IMPA2/PI4KA/PIP5K1B/PIK3CB/INPP5K/FIG4/MTMR1/PIK3C3/INPP5F/MTMR6/PPIP5K2/MTMR2/MTMR8/PIK3CA/IP6K2/CDIPT/INPP5B/INPP4B/PPIP5K1/PLCB4	2.63796993749247
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	25/2494	60/9376	1.56642608928094	PLA2G4C/PPP3CA/PPP3CC/MAP2K1/PRKCB/PLA2G4A/RAC1/PPP3CB/PRKCA/CASP9/RAC2/SRC/MAPK14/PIK3CB/BAD/NFATC2/MAPKAPK3/KRAS/MAPK1/PIK3CA/PIK3R1/PTK2/PRKCG/MAPKAPK2/SH2D2A	2.64960211883527
Organismal Systems	Nervous system	hsa04730	Long-term depression	25/2494	60/9376	1.56642608928094	PLA2G4C/GNA12/LYN/GNAQ/PLCB1/MAP2K1/PRKCB/PLA2G4A/BRAF/GNAI3/GUCY1A1/GNA13/ITPR1/PRKCA/IGF1R/KRAS/RYR1/MAPK1/PRKG1/IGF1/ITPR2/PRKCG/GUCY1B1/GNAI1/PLCB4	2.64960211883527
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	76/2494	224/9376	1.27551838698591	SLC25A5/MAPK8/CREB1/RELB/SLC25A6/ADCY3/SMAD3/NFATC3/IL15/VDAC2/MAP2K4/PPP3CA/PPP3CC/MAP2K1/CREB5/CDC26/ANAPC16/VDAC3/FOS/DLG1/POLB/CDC27/NFKB1/EGR2/PPP3CB/CREBBP/RANBP1/ATR/PRKACB/VDAC1/TBPL1/IL2RG/TGFB1/STAT5B/PIK3CB/RAN/NFATC2/SMAD2/ANAPC11/CD3D/ANAPC15/JAK1/KRAS/CRTC3/CHEK2/ADCY9/MAPK10/NFATC1/KAT2B/BAX/CD3E/MAPK1/IL15RA/TLN2/TSPO/CCND3/TRRAP/PIK3CA/ETS1/NFYB/TGFBR2/ANAPC10/MAP3K14/CD3G/BUB3/PIK3R1/HLA-DRB3/LCK/ELK1/IL1R1/TBP/CCNB2/MMP7/IL2RB/TGFB2/CDKN2A	2.51242507559747
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	48/2494	133/9376	1.35678410139221	MAPK8/GNG7/CREB1/GNAL/CAMK2D/GNAQ/PLCB1/PPP3CA/PPP3CC/GSK3B/PPP1CA/CREB5/PRKCB/PPP2R5C/FOS/GNAI3/PPP3CB/ITPR1/CALM2/GNG2/PPP1CC/PRKCA/PRKACB/PPP2R3C/ARRB1/MAPK14/PPP2R5A/GNB1/SLC18A2/GNG5/PPP2R5E/PPP2R2D/PPP2R2A/MAPK10/CACNA1D/PPP2R3A/TH/PPP2R2B/ITPR2/PRKCG/KCNJ6/GNGT2/GNAI1/CALM3/CALM1/GNG4/GNG11/PLCB4	2.49460257438416
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	11/2494	21/9376	1.96922136938175	DPYD/PANK2/PPCDC/PPCS/AASDHPPT/VNN2/BCAT2/ENPP1/UPB1/ALDH2/DPYS	2.67662334187389
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	50/2494	140/9376	1.34265093366938	RPS6/PIK3R5/PRKCE/GNG7/NRF1/SLC8A1/ADCY3/SMAD3/GNAQ/PLCB1/MEF2C/PDE3B/MAP2K1/HDAC4/GNAI3/MEF2A/GNA13/ITPR1/CALM2/GNG2/RRAS/PRKACB/RPS6KB2/GNB1/GNG5/SMAD2/MAP1LC3B/KRAS/PIK3C3/ADCY9/RYR1/MAPK1/BECN1/CAMK4/PIK3R6/ITPR2/RRAS2/GNGT2/GNAI1/CALM3/ADCY10/CALM1/PIK3R4/KLF2/MYLK4/GNG4/LIPE/GNG11/SLC8A2/PLCB4	2.45895456323562
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/2494	216/9376	1.2705456057501	CCL3L1/LY96/MAPK8/TRAF3/TANK/MAP3K5/RAP1B/CAMK2D/HSPA8/EIF2AK3/CYBA/LYN/NFATC3/MAP2K4/PPARG/RAP1A/BID/PLCB1/ATF6/TAB2/PPP3CA/VAV3/PPP3CC/GSK3B/POU2F1/FOS/NFKB1/PYCARD/RAC1/BCL2/PPP3CB/ITPR1/CALM2/PRKCA/CASP9/TLR2/TBK1/JAK2/IRAK4/TNFSF10/SRC/TNFRSF10B/MAPK14/TIRAP/PIK3CB/BAD/NFATC2/VAV1/IL18/EIF2S1/KRAS/POU2F2/VAV2/MAPK10/NFATC1/MAP2K6/BAX/MAPK1/NCF2/CASP6/PIK3CA/ERN1/MMP1/FAS/PIK3R1/PTK2/CYBB/CALM3/TRAF2/CALM1/VCAM1/NLRP3/PLCB4	2.42156511638562
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	15/2494	32/9376	1.76222935044106	PCCA/SUCLG2/SUCLA2/SUCLG1/HIBCH/LDHB/BCKDHB/DLD/ECHS1/HADHA/ACACB/PCCB/MCEE/ABAT/MMUT	2.59998457020916
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	66/2494	193/9376	1.2856056608399	ELMO1/PIK3R5/CCL4L2/CCL3L1/GNG7/RAP1B/ADCY3/LYN/DOCK2/CX3CR1/GNAQ/RAP1A/PLCB1/PAK1/FOXO3/VAV3/GSK3B/SOS1/MAP2K1/PRKCB/GRK3/NFKB1/BRAF/GNAI3/RAC1/TIAM1/GNG2/CXCL14/PRKACB/JAK2/GRK5/STAT1/RAC2/SRC/ARRB1/GNB1/SOS2/STAT5B/GNG5/PIK3CB/BAD/VAV1/KRAS/VAV2/ADCY9/HCK/MAPK1/PIK3CA/ITK/CXCL12/PTK2B/PIK3R1/PIK3R6/RASGRP2/PTK2/SHC3/XCL2/GNGT2/XCL1/GNAI1/CCL28/CCR2/CCR3/GNG4/GNG11/PLCB4	2.41340218775718
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	32/2494	83/9376	1.449415947672	GSTK1/ACSL5/PMVK/FAR2/ECI2/PEX2/PEX14/PRDX5/MPV17L2/AGPS/PEX11G/CAT/HACL1/ABCD3/PEX16/PEX7/HMGCL/NUDT7/SOD1/PIPOX/PRDX1/ACAA1/ACSL1/GNPAT/PEX3/PECR/NUDT13/NUDT12/PEX11B/SLC25A17/DDO/PXMP4	2.4756319882343
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	30/2494	77/9376	1.4647101094575	MAPK8/SMAD3/MAP2K1/NFKB1/BRAF/RAC1/CASP9/STAT1/POLK/RPS6KB2/RAC2/DDB2/TGFB1/PIK3CB/BAD/SMAD2/CDK6/JAK1/KRAS/MAPK10/BAX/MAPK1/PIK3CA/RALA/TGFBR2/PIK3R1/RAD51/GADD45B/TGFB2/CDKN2A	2.46482385056613
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	37/2494	99/9376	1.40503673462775	MAPK8/PLA2G4C/CHKA/CHPT1/SOS1/LYPLA1/MAP2K1/PRKCB/FOS/PLA2G4A/RAC1/WASF2/RHEB/SLC44A1/PDGFC/PRKCA/RPS6KB2/RAC2/PIP5K1B/SOS2/PLPP1/PIK3CB/SLC22A4/KRAS/MAPK10/MAPK1/PIK3CA/DGKH/PIK3R1/PRKCG/PDGFD/PDGFA/SLC44A2/HIF1A/SLC22A1/GPCPD1/PDGFRA	2.4388481505462
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	42/2494	115/9376	1.37300651999582	PIK3R5/GNG7/CREB1/ADCY3/CAMK2D/GNAQ/PLCB1/MAP2K1/CREB5/PRKCB/FYN/FOS/GNAI3/BCL2/ITPR1/GNG2/PRKCA/PRKACB/JAK2/KCNQ1/GNB1/GNG5/PIK3CB/KCNQ5/KRAS/ADCY9/MAPK1/PIK3CA/CAMK4/CACNA1D/KCNQ3/PIK3R1/PIK3R6/ITPR2/PRKCG/KCNJ6/CHRNA7/GNGT2/GNAI1/GNG4/GNG11/PLCB4	2.42277414213356
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	76/2494	227/9376	1.25866131579226	CCL4L2/CCL3L1/GNG7/CREB1/GNA12/ADCY3/RIPK1/NFATC3/CTNNB1/GNAQ/BID/PLCB1/AKAP13/PPP3CA/PPP3CC/GSK3B/SOS1/MAP2K1/CREB5/PRKCB/NFKB1/GNAI3/RAC1/RHEB/GNA13/PPP3CB/ITPR1/CALM2/GNG2/PRKCA/CASP9/PRKACB/TBK1/RPS6KB2/RAC2/SRC/MAPK14/GNB1/SOS2/GNG5/PIK3CB/PTGER2/NFATC2/TRADD/CDK6/JAK1/KRAS/ADCY9/NFATC1/MAP2K6/BAX/MAPK1/MDM2/PIK3CA/CXCL12/FAS/PTK2B/PIK3R1/PTK2/ITPR2/PRKCG/ELK1/IL1R1/GNGT2/GNAI1/ITGAV/CALM3/TRAF2/TRAF5/CALM1/CCR3/GNG4/GNG11/CDKN2A/PDGFRA/PLCB4	2.37483874588107
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	24/2494	59/9376	1.52925665665394	CTNNB1/FOXO3/GSK3B/SOS1/TCF7L2/MAP2K1/BRAF/CASP9/POLK/DDB2/SOS2/PIK3CB/BAD/TCF7/KRAS/BAX/MAPK1/PIK3CA/MLH1/PIK3R1/CTNNA3/ELK1/GADD45B/LEF1	2.45488309769229
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	23/2494	56/9376	1.54404857371978	TMEM258/DHRSX/MGAT5/ST6GAL1/OSTC/DAD1/B4GALT1/ALG5/DPM3/DDOST/FUT8/MAN1A1/DPM1/ALG14/MAN1C1/MAN1A2/MAGT1/DPM2/MAN2A1/ALG13/STT3B/RPN2/B4GALT3	2.45810404825637
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	34/2494	90/9376	1.42022632094805	NFATC3/PPP3CA/PPP3CC/MAP2K1/FOS/NFKB1/PPP3CB/TLR2/JAK2/ALK/STAT1/RPS6KB2/MAPK14/CD247/TIRAP/PIK3CB/NFATC2/CSNK2A1/IFNGR1/CD3D/JAK1/KRAS/NFATC1/PRKCQ/MAP2K6/CD3E/MAPK1/RASGRP1/PIK3CA/CD3G/PIK3R1/LCK/HIF1A/BATF2	2.41138577542852
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	42/2494	116/9376	1.3611702568924	RAP1B/CYBA/ACTG1/CTNNB1/RAP1A/MYL12B/VAV3/MYL12A/PRKCB/RHOH/GNAI3/CD99/RAC1/PRKCA/ITGA4/RAC2/MAPK14/TXK/RASSF5/VCL/PIK3CB/VAV1/VAV2/MSN/NCF2/PIK3CA/CLDN14/ITK/CXCL12/PTK2B/PIK3R1/CTNNA3/MMP2/PTK2/PRKCG/THY1/MYL9/MYL11/CYBB/GNAI1/MYL5/VCAM1	2.35619922050975
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	50/2494	142/9376	1.32374035713882	GAB2/FCGR2C/MAPK8/CREB1/RELB/LCP2/CYBA/TYROBP/PPARG/TAB2/PPP3CA/PPP3CC/MITF/MAP2K1/FYN/FOS/BLNK/NFKB1/RAC1/PPP3CB/ITPR1/FCGR1A/STAT1/SYK/MAPK14/TGFB1/BTK/TEC1/PIK3CB/NFATC2/IFNGR1/JAK1/MAPK10/NFATC1/MAP2K6/MAPK1/NCF2/PIK3CA/CAMK4/TGFBR2/TREM2/MAP3K14/PIK3R1/LCK/ITPR2/IL1R1/CTSK/JUNB/TRAF2/TGFB2	2.34003636843809
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/2494	30/9376	1.75439721999465	SUCLG2/SUCLA2/SUCLG1/MDH2/OGDH/SDHB/SDHC/IDH3G/DLD/DLST/IDH3B/PDHB/MDH1/ACO1	2.49129035681338
Organismal Systems	Endocrine system	hsa04924	Renin secretion	27/2494	69/9376	1.47107841428123	CREB1/GNAQ/PLCB1/PPP3CA/PPP3CC/PDE3B/GNAI3/GUCY1A1/PPP3CB/ITPR1/CALM2/PRKACB/PTGER2/ORAI1/CACNA1D/ITPR2/PDE1B/GUCY1B1/GNAI1/PDE3A/ACE/CALM3/PDE1C/NPPA/CALM1/KCNMA1/PLCB4	2.36422835421684
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/2494	91/9376	1.40461943830027	CD72/MALT1/LYN/NFATC3/PPP3CA/VAV3/PPP3CC/GSK3B/SOS1/MAP2K1/PRKCB/IFITM1/FOS/BLNK/NFKB1/RAC1/PPP3CB/RAC2/SYK/SOS2/BTK/PIK3CB/NFATC2/VAV1/KRAS/VAV2/CARD11/DAPP1/NFATC1/MAPK1/CD22/PIK3CA/PIK3R1/CD79B	2.33481789684489
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	22/2494	54/9376	1.53161662063025	ERCC1/HES1/RPA3/WDR48/RPA2/ATR/POLK/FANCL/POLH/REV3L/FANCC/BRCA1/CENPX/ERCC4/REV1/MLH1/RMI2/FANCA/RAD51/FANCD2/POLI/FAAP24	2.35839969299679
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	56/2494	163/9376	1.29158077545619	MAPK8/TRAF3/CREB1/SMAD3/NFATC3/YWHAB/MAP2K4/STAT4/BID/TAB2/SOS1/MAP2K1/CREB5/PRKCB/VDAC3/FOS/NFKB1/SLC10A1/BRAF/EGR2/BCL2/CREBBP/PRKCA/CASP9/TLR2/TBK1/JAK2/IRAK4/STAT1/SRC/YWHAZ/MAPK14/DDB2/SOS2/TGFB1/STAT5B/TIRAP/PIK3CB/BAD/NFATC2/JAK1/KRAS/MAPK10/NFATC1/YWHAQ/MAP2K6/BAX/MAPK1/PIK3CA/TGFBR2/FAS/PTK2B/PIK3R1/PRKCG/ELK1/TGFB2	2.26062581082632
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	67/2494	200/9376	1.25940657578188	RPS3/ARPC2/RAB1A/MAPK8/ARPC3/GNA12/MYO1E/BRK1/ACTG1/RIPK1/PAK1/SEC24B/TAB2/NCK1/CYTH3/FYN/LPAR1/FOS/TMED10/MYO1D/NFKB1/ABL1/PYCARD/RAC1/WASF2/GNA13/ARPC1A/CASP9/CYTH1/IRAK4/TNFSF10/TLR5/SRC/TNFRSF10B/MAPK14/CASP4/ACTR3/WASL/TIRAP/IL18/ABI1/TRADD/CYFIP2/TUBA1A/ARPC5L/ARPC4/MAPK10/BAX/WIPF3/MAPK1/CLDN14/SEC24D/FAS/MYO5A/WIPF1/TUBB6/MYH10/ARPC5/MYH14/HCLS1/IL1R1/MYO10/ACTR3B/TRAF2/NLRP3/ACTR3C/MYO6	2.23226528284477
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	27/2494	70/9376	1.45006300836293	RAP1B/ELOB/RAP1A/PAK1/RBX1/SOS1/MAP2K1/RAPGEF1/CUL2/BRAF/RAC1/CREBBP/GAB1/SOS2/TGFB1/PIK3CB/BAD/KRAS/VHL/ELOC/MAPK1/PIK3CA/ETS1/PRCC/PIK3R1/HIF1A/TGFB2	2.27518828757586
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	38/2494	105/9376	1.3605529461183	MAPK8/RELB/MALT1/NFATC3/CLEC7A/PAK1/CBLB/PPP3CA/PPP3CC/NFKB1/PYCARD/EGR2/PPP3CB/ITPR1/CALM2/RRAS/STAT1/SYK/SRC/MAPK14/PIK3CB/NFATC2/KRAS/KSR1/MAPK10/NFATC1/MAPK1/MDM2/PIK3CA/FCER1G/MAP3K14/PIK3R1/ITPR2/RRAS2/MAPKAPK2/CALM3/CALM1/NLRP3	2.23654137176472
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	32/2494	86/9376	1.39885492624158	MAPK8/CAMK2D/MAP2K4/PAK1/CBLB/NCK1/GSK3B/SOS1/MAP2K1/PRKCB/BRAF/ABL1/PRKCA/GAB1/RPS6KB2/SRC/SOS2/STAT5B/PIK3CB/BAD/CBL/KRAS/CDKN1B/MAPK10/MAPK1/PIK3CA/PIK3R1/PTK2/NRG1/PRKCG/SHC3/ELK1	2.23682937594902
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	14/2494	31/9376	1.69780376128515	PCCA/MDH2/AFMID/ACAT2/GRHPR/DLD/CAT/GCSH/PCCB/HYI/MDH1/MCEE/ACO1/MMUT	2.34261558763224
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	54/2494	158/9376	1.28486595677728	STAG1/SMAD3/CCNH/YWHAB/RBX1/GSK3B/CUL1/CDC26/ANAPC16/PPP2R5C/CDC27/ABL1/STAG2/CREBBP/ATR/YWHAZ/MAD2L2/PPP2R5A/TGFB1/SMAD2/ZBTB17/CDC14A/ANAPC11/ORC4/PPP2R5E/CDK6/ANAPC15/CDKN1B/CHEK2/MTBP/ORC3/NIPBL/YWHAQ/SFN/PDS5B/CCND3/MDM2/ANAPC10/SMC1B/ORC2/MAU2/CDC25B/BUB3/CDKN2D/ORC5/YWHAH/RBL1/DBF4B/CCNB2/CDC14B/NDC80/GADD45B/TGFB2/CDKN2A	2.17383847798667
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	65/2494	195/9376	1.25314087142475	H3-3A/H3-3B/MACROH2A1/H2AZ1/H2AZ2/H2AJ/H4C3/ATG7/H2AC20/SLC25A5/HDAC9/H2AX/SLC25A6/CYBA/ACTG1/VDAC2/CLEC7A/PLCB1/MACROH2A2/FPR1/MAP2K1/PRKCB/VDAC3/HAT1/HDAC4/NFKB1/H2AC6/RAC1/SIGLEC9/FCGR1A/PRKCA/TLR2/VDAC1/RAC2/SYK/SRC/MAPK14/CASP4/PIK3CB/C5/H2BC21/HDAC3/H4C5/H2BC4/MAPK1/NCF2/H2BC18/PIK3CA/H2BC12/FPR2/PIK3R1/H2AC17/PRKCG/H2BC15/H4C8/VWF/H2BC6/CYBB/H4C1/H2BC11/CR1L/H2AC16/H3C1/H2BC9/PLCB4	2.15035969556351
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	34/2494	93/9376	1.37441256865941	MAML3/MAML2/MAPK8/NFATC3/STAT4/PPP3CA/PPP3CC/FOS/NFKB1/PPP3CB/JAK2/STAT1/MAPK14/IL2RG/CD247/STAT5B/NFATC2/IFNGR1/CD3D/JAK1/MAPK10/NFATC1/PRKCQ/CD3E/MAPK1/IL12RB1/RBPJ/CD3G/HLA-DRB3/LCK/NOTCH2/IL12RB2/RUNX3/IL2RB	2.18436015938994
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	27/2494	71/9376	1.42963958570993	MAPK8/ESR1/FOXO3/GSK3B/SOS1/MAP2K1/FOS/NFKB1/JAK2/STAT1/SRC/MAPK14/SOS2/STAT5B/PIK3CB/PRL/KRAS/MAPK10/MAPK1/SOCS6/PIK3CA/SOCS5/PIK3R1/TH/SHC3/ESR2/PRLR	2.1875188466364
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	41/2494	116/9376	1.32876144125211	PCCA/PGLS/SUCLG2/SUCLA2/ESD/SUCLG1/GLUD1/MDH2/ME1/HIBCH/ACAT2/OGDH/SDSL/SDHB/SDHC/TKT/PGK1/IDH3G/FBP1/DLD/SDS/CAT/ENO4/ME3/ECHS1/DLST/TALDO1/PRPS2/GOT1/IDH3B/PDHB/ADH5/GCSH/PCCB/MDH1/MCEE/IDNK/ACO1/MMUT/TKTL1/PSPH	2.14477088527987
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	35/2494	97/9376	1.35649269587216	GNG7/CREB1/ADCY3/CAMK2D/GNAQ/PLCB1/PRKCB/FOS/RPS6KA5/PER3/GNAI3/GUCY1A1/ITPR1/CALM2/GNG2/PRKCA/PRKACB/GNB1/GNG5/ADCY9/RYR1/MAPK1/PRKG1/CACNA1D/PRKCG/KCNJ6/GUCY1B1/GNGT2/GNAI1/CALM3/ADCY10/CALM1/GNG4/GNG11/PLCB4	2.12452792798554
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	22/2494	56/9376	1.47691602703632	DISP1/FBXW11/CUL3/TPTEP2-CSNK1E/SMURF2/GSK3B/CUL1/BTRC/SPOP/GRK3/PTCH2/BCL2/PRKACB/ARRB1/SUFU/CSNK1A1/SPOPL/SMURF1/EFCAB7/CSNK1G3/GAS1/MOSMO	2.15478777698279
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	57/2494	170/9376	1.26051228831549	IGF2/ARID2/WNT2B/SMAD3/ACTG1/CTNNB1/GSK3B/SOS1/TCF7L2/MAP2K1/PRKCB/MGST3/BRAF/MGST2/ARID1B/PRKCA/GAB1/POLK/RPS6KB2/GSTP1/GSTT1/IGF1R/DDB2/SOS2/TGFB1/PIK3CB/BAD/SMARCC1/SMAD2/CDK6/TCF7/KRAS/TXNRD1/BAX/CSNK1A1/MAPK1/PIK3CA/ACTL6A/TGFBR2/FRAT2/PIK3R1/GSTM1/TXNRD3/PRKCG/SHC3/FRAT1/ELK1/GSTO1/SMARCD3/MGST1/FZD6/GADD45B/GSTO2/TGFB2/CDKN2A/WNT2/LEF1	2.06344889727479
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	28/2494	75/9376	1.40351777599572	ERCC1/MAP3K5/BID/MGST3/MGST2/BCL2/CASP9/XPA/GSTP1/GSTT1/POLH/REV3L/PIK3CB/BAD/BRCA1/BAX/MAPK1/MDM2/PIK3CA/MSH2/MLH1/FAS/PIK3R1/GSTM1/GSTO1/MGST1/GSTO2/CDKN2A	2.11205395898043
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	28/2494	75/9376	1.40351777599572	COP1/BID/BCL2/SESN1/PPM1D/CASP9/ATR/PERP/TNFRSF10B/CCNG1/SIVA1/DDB2/SESN3/CDK6/SIAH1/RRM2B/CHEK2/TP53I3/BAX/SFN/CCND3/MDM2/FAS/IGF1/THBS1/CCNB2/GADD45B/CDKN2A	2.11205395898043
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	37/2494	104/9376	1.3374868916168	PLA2G6/TAFAZZIN/PLA2G4C/LPIN2/CHKA/CHPT1/SGMS1/LYPLA1/GPD2/PLA2G4A/PLD4/PGS1/PLPP1/SAMD8/AGPAT4/PLB1/GPAT3/PTDSS1/CEPT1/AGPAT3/LPCAT2/SGMS2/CDIPT/SELENOI/GNPAT/PEMT/MBOAT1/PLAAT2/MBOAT2/DGKH/PNPLA7/LCLAT1/CDS2/PLPP4/ADPRM/CDS1/GPCPD1	2.08335555900091
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	47/2494	137/9376	1.28972892606489	CTSH/MAPK8/MAP3K5/EIF2AK3/ACTG1/RIPK1/IL3RA/BID/MAP2K1/FOS/NFKB1/CTSW/GZMB/BCL2/ITPR1/CASP9/CTSS/TNFSF10/TNFRSF10B/CTSF/PIK3CB/BAD/AIFM1/EIF2S1/TRADD/KRAS/TUBA1A/PRF1/MAPK10/ENDOG/BAX/MAPK1/CASP6/PARP4/PIK3CA/ERN1/FAS/MAP3K14/DFFA/PIK3R1/ITPR2/HTRA2/CTSK/TRAF1/TRAF2/PARP3/GADD45B	2.05644067474284
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	36/2494	101/9376	1.33999221894924	PRKCE/MAPK8/SMAD3/PLCB1/FOXO1/PRKCB/NFKB1/RAC1/BCL2/PRKCA/COL3A1/JAK2/STAT1/MAPK14/TGFB1/STAT5B/PIK3CB/VEGFB/SMAD2/KRAS/CDKN1B/MAPK10/NFATC1/BAX/MAPK1/PIK3CA/TGFBR2/PIK3R1/MMP2/COL1A1/CYBB/DIAPH1/COL1A2/VCAM1/TGFB2/PLCB4	2.06799380907902
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	24/2494	63/9376	1.432160995914	SMYD3/CAMKMT/PHYKPL/KMT2E/ACAT2/ASH1L/ALDH9A1/EHMT1/TMLHE/DLD/HADH/KMT5B/ECHS1/DLST/HADHA/PIPOX/GCDH/KMT2C/SMYD2/MECOM/ALDH2/NSD3/SETMAR/COLGALT2	2.07179876358357
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	24/2494	63/9376	1.432160995914	ERCC1/CCNH/POLR2L/POLE4/RPA3/RBX1/ERCC8/RPA2/MNAT1/POLR2G/POLR2I/GTF2H5/ERCC6/XPA/CUL4A/DDB2/POLD3/RFC2/ERCC4/XPC/RFC4/UVSSA/ERCC3/POLE2	2.07179876358357
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	69/2494	212/9376	1.22358566219304	SIPA1L1/DOCK4/RAP1B/LCP2/ADCY3/ACTG1/CTNNB1/GNAQ/RAP1A/PLCB1/SIPA1L3/FARP2/VAV3/FPR1/MAP2K1/PRKCB/LPAR1/SIPA1L2/RAPGEF1/BRAF/GNAI3/RAC1/APBB1IP/TIAM1/PDGFC/CALM2/PRKCA/RRAS/EVL/RAC2/SRC/IGF1R/MAPK14/SKAP1/RASSF5/RAPGEF2/PIK3CB/VAV1/VEGFB/INSR/KRAS/PRKD3/VAV2/ADCY9/MAGI3/MAP2K6/MAPK1/TLN2/PIK3CA/RALA/EFNA5/IGF1/PIK3R1/RASGRP2/PARD6A/PRKCG/FYB1/THBS1/PDGFD/PDGFA/GNAI1/CALM3/CALM1/FGF7/MAGI2/RGS14/ARAP3/PDGFRA/PLCB4	1.98219268488458
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	47/2494	138/9376	1.28038306428181	ADCY3/CAMK2D/FBXW11/YWHAB/PPP3CA/RBX1/PPP3CC/RPS6KA3/CUL1/MAP2K1/PPP1CA/BTRC/CDC26/ANAPC16/PPP2R5C/CDC27/CPEB3/PPP3CB/ITPR1/CALM2/PPP1CC/PRKACB/YWHAZ/SPDYE2/IGF1R/MAPK14/MAD2L2/PPP2R5A/RPS6KA2/ANAPC11/PPP2R5E/ANAPC15/ADCY9/YWHAQ/MAPK1/SPDYE18/ANAPC10/SMC1B/SPDYE21/SPDYE1/IGF1/YWHAH/ITPR2/CCNB2/CALM3/CALM1/SPDYE5	1.99746358533865
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	47/2494	138/9376	1.28038306428181	RPS6/MAPK8/INPP5A/RPTOR/FOXO1/CBLB/GSK3B/SOS1/PDE3B/MAP2K1/PPP1CA/PRKAR1B/RAPGEF1/BRAF/RHEB/PTPN1/CALM2/PPP1CC/PRKACB/PRKAR2A/RPS6KB2/FBP1/SOS2/EIF4E2/PYGL/PIK3CB/BAD/GYS1/INSR/CBL/PHKB/KRAS/MAPK10/ACACB/MAPK1/PIK3CA/PIK3R1/SHC3/ELK1/PHKG1/CALM3/PPP1R3F/SH2B2/CALM1/SORBS1/PRKAR2B/LIPE	1.99746358533865
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	27/2494	73/9376	1.39047137788226	FHIT/FOXO3/SOS1/MAP2K1/PRKCB/BRAF/RASSF1/PRKCA/CASP9/ALK/POLK/DDB2/SOS2/RASSF5/STAT5B/PIK3CB/BAD/CDK6/KRAS/BAX/MAPK1/PIK3CA/PIK3R1/STK4/PRKCG/GADD45B/CDKN2A	2.01611663578095
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	42/2494	122/9376	1.29422745737311	NCOA1/NCOA2/ACTG1/NCOA3/MED13L/CTNNB1/PLCB1/ESR1/MED27/FOXO1/GSK3B/MAP2K1/PRKCB/TBC1D4/MED30/RHEB/CREBBP/PRKCA/CASP9/PRKACB/STAT1/SRC/PIK3CB/BAD/NCOR1/KRAS/HDAC3/SIN3A/KAT2B/MAPK1/ATP1B1/SLC16A10/MDM2/PIK3CA/MED4/PIK3R1/PRKCG/NOTCH2/THRB/ITGAV/HIF1A/PLCB4	1.96913229585109
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/2494	109/9376	1.3106243976369	MAPK8/SMAD3/NFATC3/PPP3CA/PPP3CC/FOS/NFKB1/PPP3CB/JAK2/STAT1/MAPK14/IL2RG/TGFB1/CD247/STAT5B/NFATC2/RORA/SMAD2/IFNGR1/CD3D/JAK1/MAPK10/NFATC1/PRKCQ/CD3E/MAPK1/IL12RB1/TGFBR2/CD3G/HLA-DRB3/LCK/RUNX1/IL1R1/IL1RAP/HIF1A/IL21R/IL2RB/IL6ST	1.96361237297676
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	36/2494	103/9376	1.31397295256188	CCL3L1/MAPK8/GNAL/GNAQ/MAP2K4/PLCB1/FOS/NFKB1/GNAI3/TLR2/IRAK4/MAPK14/TGFB1/CD247/PIK3CB/SMAD2/IFNGR1/CD3D/PPP2R2D/PPP2R2A/MAPK10/CD3E/MAPK1/PIK3CA/TGFBR2/FAS/CD3G/PIK3R1/PPP2R2B/C1QB/GNA15/C1QA/GNAI1/ACE/TGFB2/PLCB4	1.92875581375903
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	44/2494	130/9376	1.27241996175436	MAPK8/GNG7/CREB1/ADCY3/MAP2K4/PLCB1/SOS1/MAP2K1/CREB5/FOS/NFKB1/GNAI3/GNG2/PRKCA/COL3A1/PRKACB/SRC/ARRB1/MAPK14/GNB1/SOS2/TGFB1/GNG5/PIK3CB/VEGFB/SMAD2/KRAS/ADCY9/MAPK10/MAPK1/PIK3CA/TGFBR2/MMP1/PIK3R1/MMP2/SHC3/GNA15/COL1A1/GNGT2/GNAI1/COL1A2/GNG4/GNG11/PLCB4	1.88282600431045
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	40/2494	117/9376	1.28527268864077	MACROH2A1/H2AZ1/H2AZ2/H2AJ/H2AC20/H2AX/ARID2/BICRAL/ACTG1/MACROH2A2/H2AC6/EPC1/ARID1B/YEATS4/ACTR6/EPC2/MEAF6/CDK2AP1/INO80/MORF4L2/BCL7C/SMARCC1/UCHL5/GATAD2A/BCL7B/MORF4L1/BAZ2B/MTA3/RSF1/BICRA/TRRAP/ACTL6A/MRGBP/ZNHIT1/H2AC17/ING3/SMARCD3/BCL7A/BRD8/H2AC16	1.86916488139401
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	18/2494	46/9376	1.47107841428123	PSME4/PSMD8/PSMB7/PSMA5/POMP/PSMB1/PSMA7/PSMB5/PSMB6/PSMC5/PSMD4/PSMD12/PSMD2/PSMF1/PSMA4/PSMB2/PSMD14/PSMD1	1.92800354047999
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	45/2494	134/9376	1.2624926689727	PLA2G6/PRKCH/PRKCE/PLA2G4C/GNA12/ADCY3/GNAQ/MYL6/PLCB1/MAP2K1/PPP1CA/PRKCB/PLA2G4A/PPP1R12B/BRAF/KCNMB4/PPP1R12A/GUCY1A1/GNA13/ITPR1/CALM2/PPP1CC/PRKCA/PRKACB/ADCY9/PRKCQ/MAPK1/PRKG1/CACNA1D/RAMP1/MYH10/ITPR2/PRKCG/MYH14/MYL6B/MYL9/GUCY1B1/IRAG1/CALM3/NPPA/CALM1/KCNMA1/MYLK4/CALCRL/PLCB4	1.84231176042611
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	58/2494	178/9376	1.22498040240397	MAPK8/INVS/WNT2B/CAMK2D/SMAD3/FBXW11/NFATC3/TPTEP2-CSNK1E/CTNNB1/NLK/PLCB1/PPARD/CTNNBIP1/PPP3CA/RBX1/PPP3CC/GSK3B/CUL1/TCF7L2/PRKCB/BTRC/DKK1/TBL1XR1/TBL1X/RAC1/PSEN1/CTBP2/PPP3CB/CREBBP/PRKCA/PRKACB/RAC2/ANKRD6/NFATC2/CSNK2A1/SIAH1/TCF7/SENP2/MAPK10/SERPINF1/NFATC1/CSNK1A1/CCND3/DAAM1/FRAT2/CCDC88C/PRKCG/FRAT1/ZNRF3/CBY1/PRICKLE3/ROR2/FZD6/CACYBP/MMP7/WNT2/LEF1/PLCB4	1.82425067824739
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	15/2494	37/9376	1.5240902490301	CTNNB1/PPARG/TCF7L2/MAP2K1/BRAF/TFG/POLK/DDB2/TCF7/KRAS/BAX/MAPK1/PAX8/GADD45B/LEF1	1.92279632086513
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/2494	34/9376	1.54799754705411	CRY1/CREB1/FBXW11/TPTEP2-CSNK1E/RBX1/CUL1/BTRC/DBP/PER3/NR1D2/RORA/CRY2/NR1D1/RORB	1.92696874331653
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	22/2494	59/9376	1.40181860193277	GPX1/GSTK1/MGST3/PRDX6/SMS/MGST2/GGCT/GSTP1/GSTT1/ODC1/RRM2B/GCLC/RRM1/GPX4/LAP3/GSTM1/GSTO1/GGT7/GPX7/MGST1/GSTO2/LANCL1	1.86377947602858
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	93/2494	300/9376	1.16542101042502	IGF2/MAP4K3/MAPK8/STK3/PLA2G4C/MAP3K5/GNA12/RAP1B/RELB/MAP2K5/HSPA8/NFATC3/NLK/MAP2K4/RAP1A/RASA1/PAK1/MEF2C/TAB2/PPP3CA/PPP3CC/SOS1/RPS6KA3/MAP2K1/PRKCB/FOS/PLA2G4A/NF1/RPS6KA5/RASA2/TAOK3/NFKB1/BRAF/DUSP1/CACNA2D3/RAC1/PPP3CB/PDGFC/PRKCA/RRAS/PRKACB/IRAK4/MAP4K4/RAC2/ARRB1/IGF1R/MAPK14/SOS2/TGFB1/MAP3K20/RPS6KA2/MAP3K13/RAPGEF2/VEGFB/INSR/TRADD/MAPKAPK3/MAX/KRAS/PPM1A/STMN1/MAPK10/NFATC1/MAP2K6/MAP3K12/MAPK1/RASGRP1/EFNA5/TGFBR2/FAS/MAP3K14/CACNA1D/CDC25B/IGF1/RASGRP2/STK4/MECOM/PRKCG/RRAS2/CACNB4/MAPKAPK2/PDGFD/ELK1/PDGFA/IL1R1/IL1RAP/TRAF2/FGF7/FLT3/GADD45B/TGFB2/MAPK8IP1/PDGFRA	1.75299461356946
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	20/2494	53/9376	1.41865004312236	RAB11A/SLC8A1/GNAQ/PLCB1/ESR1/CLTA/PRKCB/PRKCA/PRKACB/DNM3/ATP2B1/AP2S1/ATP2B4/ADCY9/ATP1B1/CLTB/PRKCG/VDR/SLC8A2/PLCB4	1.83987264151976
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	75/2494	238/9376	1.18469200029651	GAB2/PLA2G6/IGF2/MAPK8/GNG7/RASAL2/PLA2G4C/RAP1B/RAP1A/RASA1/PAK1/SOS1/MAP2K1/PRKCB/PLA2G4A/NF1/RASA2/NFKB1/ABL1/RALGAPA2/RAC1/RASSF1/EXOC2/TIAM1/PDGFC/CALM2/GNG2/SHOC2/PRKCA/RRAS/PRKACB/TBK1/HTR7/GAB1/RAC2/IGF1R/GNB1/SOS2/RASSF5/GNG5/PIK3CB/BAD/VEGFB/INSR/KRAS/KSR1/MAPK10/MAPK1/RASGRP1/RGL1/PIK3CA/RALA/ETS1/EFNA5/RALGAPB/PLAAT2/IGF1/PIK3R1/RASGRP2/STK4/PRKCG/RRAS2/SHC3/PDGFD/ELK1/PDGFA/GNGT2/CALM3/RASA4B/CALM1/FGF7/FLT3/GNG4/GNG11/PDGFRA	1.73735078658364
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	41/2494	122/9376	1.26341251791184	MAPK8/CREB1/ADCY3/GNAQ/MAP2K4/PLCB1/GSK3B/SOS1/MAP2K1/CREB5/PRKCB/FOS/GNAI3/CREBBP/ITPR1/PRKCA/PRKACB/JAK2/STAT1/MAPK14/SOS2/STAT5B/PIK3CB/KRAS/ADCY9/MAPK10/MAP2K6/MAPK1/PIK3CA/CACNA1D/IGF1/PIK3R1/PTK2/ITPR2/PRKCG/SHC3/GNAI1/JUNB/ADCY10/CSHL1/PLCB4	1.76290173861616
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/2494	99/9376	1.2911148372255	MAPK8/ADCY3/NCOA3/ESR1/SOS1/MAP2K1/FOS/BRAF/BCL2/PRKACB/RPS6KB2/SRC/IGF1R/MAPK14/SOS2/PIK3CB/BAD/NCOR1/KRAS/CDKN1B/ADCY9/MAPK10/BAX/MAPK1/MDM2/PIK3CA/IGF1/PIK3R1/MMP2/PTK2/SHC3/NOTCH2/ESR2/CDKN2A	1.75289010024358
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	8/2494	17/9376	1.76914005377612	MARS1/PAPSS2/KYAT3/TXNRD1/SEPHS1/TXNRD3/SEPSECS/PSTK	1.91069643795016
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	15/2494	38/9376	1.48398261089773	NAMPT/NT5C2/NMNAT1/QPRT/SIRT3/CD38/BST1/SIRT5/ENPP1/NNT/NUDT13/NUDT12/SARM1/NT5E/NNMT	1.79957996816153
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	15/2494	38/9376	1.48398261089773	PRKCB/NR3C2/PRKCA/PIK3CB/INSR/KRAS/SFN/MAPK1/ATP1B1/NEDD4L/PIK3CA/IGF1/PIK3R1/HSD11B2/PRKCG	1.79957996816153
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	51/2494	157/9376	1.22121371546489	PLA2G6/ELMO1/RAB7A/CREB1/UQCRFS1/VPS8/CAMK2D/NFATC3/CX3CR1/PPARG/PPARD/ATP11B/MAP2K1/GPR132/RAC1/ATP8A1/ATP11A/JAK2/CD47/HAVCR1/MAPK14/VPS41/TGFB1/ODC1/PTGER2/NFATC2/DOCK1/NFATC1/AXL/ANO6/MAPK1/P2RY12/ATP11C/PANX1/ANO5/RAB14/ADAM17/PTK2/C1QB/MAPKAPK2/THBS1/XKR6/C1QA/ITGAV/P2RY6/ITGB5/PROS1/HIF1A/XKR8/MFGE8/P2RY2	1.68266049065629
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	37/2494	110/9376	1.26453306116498	MAPK8/ADCY3/RPS6KA3/PDE3B/MAP2K1/CDC26/ANAPC16/STK10/CDC27/BRAF/GNAI3/CPEB3/PRKACB/SPDYE2/IGF1R/MAPK14/MAD2L2/RPS6KA2/PIK3CB/ANAPC11/ANAPC15/KRAS/ADCY9/MAPK10/MAPK1/SPDYE18/PIK3CA/ANAPC10/SPDYE21/SPDYE1/CDC25B/IGF1/PIK3R1/KIF22/GNAI1/CCNB2/SPDYE5	1.67998993903258
Human Diseases	Substance dependence	hsa05032	Morphine addiction	31/2494	91/9376	1.28068242903848	GNG7/PDE8A/PDE4D/ADCY3/PDE4B/PDE3B/PDE7A/PRKCB/GRK3/PDE4A/GNAI3/PDE7B/GNG2/PRKCA/PRKACB/GRK5/OPRM1/ARRB1/GNB1/GNG5/ADCY9/PDE2A/PRKCG/KCNJ6/PDE1B/GNGT2/GNAI1/PDE3A/PDE1C/GNG4/GNG11	1.61965119966039
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2494	21/9376	1.61118112040325	CHST11/UST/CHSY3/CSGALNACT2/CHST15/CHST13/CSGALNACT1/CHST7/CHST12	1.6878514080096
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	30/2494	89/9376	1.26722110593514	MAP2K5/ADCY3/GNAQ/PLCB1/SOS1/MAP2K1/PRKCB/LPAR1/GNAI3/GUCY1A1/ITPR1/PDGFC/PRKCA/PRKACB/SRC/SOS2/KRAS/TUBA1A/ADCY9/MAPK1/PRKG1/TUBB6/ITPR2/PRKCG/PDGFD/PDGFA/GUCY1B1/GNAI1/PDGFRA/PLCB4	1.52477079923117
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	16/2494	43/9376	1.39885492624158	ACSL5/ECI2/ACAT2/ALDH9A1/ACAA2/ACADM/HADH/ECHS1/HADHB/HADHA/GCDH/ADH5/ACAA1/ACSL1/ALDH2/ACADSB	1.57802937697308
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	31/2494	93/9376	1.25314087142475	MAPK8/PLA2G4C/ADCY3/CAMK2D/GNAQ/MAP2K4/PLCB1/SOS1/MAP2K1/PRKCB/PLA2G4A/ITPR1/CALM2/PRKCA/PRKACB/SRC/MAPK14/SOS2/KRAS/ADCY9/MAPK10/MAP2K6/MAPK1/PTK2B/CACNA1D/MMP2/ITPR2/ELK1/CALM3/CALM1/PLCB4	1.47684901773821
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/2494	83/9376	1.268238954213	L3MBTL4/MBD5/SFMBT2/FOXK2/JARID2/PCGF5/UBE2D2/SCML1/SCMH1/YAF2/CREBBP/ASXL2/AUTS2/MTF2/AEBP2/FOXK1/MAX/KDM2B/RNF2/PHC3/ASXL1/OGT/UBE2D1/TEX10/PHF19/USP45/KDM2A/CBX6	1.47760874748681
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/2494	34/9376	1.4374262936931	POLR1F/POLR2L/POLR1D/POLR1G/POLR2G/POLR2I/POLR3GL/POLR3K/POLR1E/POLR3F/POLR3C/POLR1C/POLR3B	1.53815797166
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	5/2494	10/9376	1.87971130713713	BPNT2/PAPSS2/ETHE1/MPST/TST	1.67548145799056
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/2494	28/9376	1.47691602703632	ELOVL5/HACD4/HSD17B12/ACAA2/HADH/ECHS1/HADHB/HADHA/ACOT7/MECR/ELOVL7	1.52138142609748
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/2494	44/9376	1.367062768827	TMEM258/OSTC/DAD1/B4GALT1/DDOST/FUT8/MAN1A1/ALG14/MAN1C1/MAN1A2/MAGT1/MAN2A1/ALG13/STT3B/RPN2/B4GALT3	1.46911515241824
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	63/2494	205/9376	1.15533475463063	MAPK8/TRAF3/RELB/LYN/RIPK1/MAP2K4/BID/PSMD8/HES1/TAB2/BLNK/ENTPD1/NFKB1/RAC1/BCL2/CIR1/CASP9/TLR2/TBK1/IRAK4/STAT1/POLK/SYK/CD58/MAPK14/DDB2/CD247/BTK/PIK3CB/PSMC5/CD3D/TRADD/NEDD4/CDK6/PSMD4/PSMD12/JAK1/CDKN1B/FCER2/PSMD2/SIN3A/MAPK10/MAP2K6/BAX/CD3E/CCND3/NCOR2/MDM2/PIK3CA/PSMD14/FAS/MAP3K14/RBPJ/CD3G/PSMD1/PIK3R1/HLA-DRB3/SAP30/TRAF2/CD44/RUNX3/TRAF5/GADD45B	1.35367294232099
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	42/2494	133/9376	1.18718608871819	MAPK8/SMAD3/TPTEP2-CSNK1E/GABARAPL2/NLK/FOXO1/FOXO3/SOS1/MAP2K1/C8orf44-SGK3/BRAF/CREBBP/TNFSF10/IGF1R/MAPK14/SOS2/TGFB1/CAT/PIK3CB/HOMER3/INSR/KRAS/CDKN1B/MAPK10/MAPK1/S1PR4/HOMER1/FBXO25/MDM2/PIK3CA/TGFBR2/IGF1/CDKN2D/PIK3R1/STK4/IL7R/CCNB2/FBXO32/KLF2/HOMER2/GADD45B/TGFB2	1.30878841569223
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	52/2494	168/9376	1.16363080918013	MACROH2A1/H2AZ1/H2AZ2/H2AJ/H2AC20/FTH1/SLC25A5/H2AX/MAPK8/PLA2G4C/SLC25A6/CAMK2D/RIPK1/VDAC2/STAT4/BID/MACROH2A2/GLUD1/CHMP4B/VDAC3/PLA2G4A/H2AC6/CHMP5/PYCARD/BCL2/JAK2/TNFSF10/STAT1/VDAC1/TNFRSF10B/PYGL/STAT5B/AIFM1/IFNGR1/TRADD/CHMP2B/JAK1/MAPK10/CHMP6/RBCK1/BAX/SHARPIN/FAS/SPATA2L/CHMP2A/H2AC17/RNF103-CHMP3/CYBB/TRAF2/TRAF5/H2AC16/NLRP3	1.28828987100579
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	12/2494	32/9376	1.40978348035285	ATG7/IGBP1/ATG5/GABARAPL2/ATG10/RPTOR/WIPI1/ATG3/PIK3C3/BECN1/PIK3R4/ATG9B	1.39778234126974
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	37/2494	116/9376	1.19912617869093	GNG7/PLA2G4C/DLGAP1/ADCY3/GNAQ/PLCB1/PPP3CA/PPP3CC/PRKCB/PLA2G4A/GRK3/GNAI3/PPP3CB/ITPR1/GNG2/PRKCA/PRKACB/GNB1/GNG5/HOMER3/GRIK1/ADCY9/MAPK1/HOMER1/SLC38A1/CACNA1D/SLC1A2/ITPR2/PRKCG/GNGT2/GNAI1/GRIK2/TRPC1/HOMER2/GNG4/GNG11/PLCB4	1.29905754436036
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	15/2494	42/9376	1.34265093366938	IDO2/KYNU/KYAT3/AFMID/ACAT2/ALDH9A1/DLD/CAT/KMO/HADH/ECHS1/DLST/HADHA/GCDH/ALDH2	1.33973590020914
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	28/2494	86/9376	1.22399806046139	SNTB1/SLC8A1/ACTG1/CTNNB1/DTNA/TCF7L2/SSPN/CACNA2D3/ITGA4/LAMA2/ITGA6/TCF7/SNTB2/SGCE/CACNA1D/ITGA9/CTNNA3/CACNB4/ITGB4/ITGAV/ITGB5/ITGB8/SGCG/ACTN2/ITGB6/LAMA1/SLC8A2/LEF1	1.25620973649991
Human Diseases	Substance dependence	hsa05034	Alcoholism	58/2494	191/9376	1.14160477292098	H3-3A/H3-3B/MACROH2A1/H2AZ1/H2AZ2/H2AJ/H4C3/H2AC20/HDAC9/H2AX/GNG7/CREB1/MACROH2A2/SOS1/MAP2K1/PPP1CA/CREB5/HAT1/HDAC4/H2AC6/BRAF/GNAI3/CALM2/GNG2/PPP1CC/PRKACB/GNB1/SOS2/SLC18A2/GNG5/SLC29A3/H2BC21/KRAS/HDAC3/H4C5/H2BC4/MAPK1/H2BC18/CAMK4/H2BC12/H2AC17/TH/SHC3/H2BC15/H4C8/PKIA/H2BC6/GNGT2/GNAI1/H4C1/CALM3/CALM1/H2BC11/H2AC16/H3C1/GNG4/GNG11/H2BC9	1.19023173009465
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	29/2494	90/9376	1.21136950904393	CREB1/ATG5/ADCY3/PPARG/RPTOR/FOXO1/FOXO3/CREB5/NFKB1/RHEB/SESN1/APPL1/PRKACB/RPS6KB2/EHMT1/IGF1R/EIF4E2/CAT/SESN3/PIK3CB/INSR/KRAS/ADIPOR1/ADCY9/BAX/PIK3CA/CAMK4/IGF1/PIK3R1	1.21290219593561
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	55/2494	181/9376	1.1423659877629	FCGR2C/RAB7A/MAPK8/CREB1/TLR1/CAMK2D/MALT1/IRAK2/CLEC7A/BID/PPP3CA/PPP3CC/CIITA/NFKB1/NFYC/BCL2/PPP3CB/CREBBP/FCGR1A/CALM2/CASP9/CTSS/TLR2/JAK2/IRAK4/STAT1/SYK/SRC/RIPK2/MAPK14/TGFB1/TIRAP/BAD/IL18/IFNGR1/TRADD/JAK1/PIK3C3/KSR1/MAPK10/CORO1A/BAX/MAPK1/ATP6V0A1/NFYB/FCER1G/NFYA/ATP6V0D1/ATP6V0B/HLA-DRB3/VDR/CALM3/CALM1/CR1L/TGFB2	1.16424986154835
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/2494	108/9376	1.18352193412338	EEF1A1/SUMO2/NUP214/KPNA3/NUP98/SUMO1/NUP54/NXT1/THOC7/ALYREF/IPO11/XPO4/PYM1/SEC13/RAN/PHAX/NUP37/NUP153/MAGOH/NUP42/NMD3/SENP2/KPNA1/SRRM1/KPNA6/NUP210L/NUP133/NUP107/RANBP17/SNUPN/NUP88/THOC5/KPNA4/NUP35	1.15473777033222
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	31/2494	98/9376	1.18920511267859	CAMK1D/PRKCE/CREB1/ADCY3/CAMK2D/GNAQ/PLCB1/CREB5/PRKCB/ITPR1/CALM2/PRKCA/PRKACB/ATP2B1/ATF1/ORAI1/ATP2B4/PRKD3/ADCY9/ATP1B1/CAMK1/CAMK4/PDE2A/CACNA1D/ITPR2/PRKCG/CALM3/NPPA/CALM1/LIPE/PLCB4	1.13343142641163
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	33/2494	105/9376	1.18153282162905	CCL4L2/LY96/TRAF3/ERC1/RELB/MALT1/LYN/RIPK1/TAB2/PRKCB/BLNK/NFKB1/BCL2/IRAK4/EDA/SYK/TNFSF13B/BTK/TIRAP/CSNK2A1/TRADD/CARD11/PRKCQ/CXCL12/MAP3K14/LCK/IL1R1/TRAF1/TRAF2/TRAF5/VCAM1/GADD45B/CARD14	1.12606392563867
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/2494	57/9376	1.25314087142475	ACSL5/ACAT2/ELOVL5/HACD4/HSD17B12/ACAA2/CBR4/ACADM/HADH/ECHS1/HADHB/OXSM/HADHA/ACAA1/ACSL1/MECR/MCAT/ELOVL7/ACADSB	1.15396216919627
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	16/2494	47/9376	1.27980344315719	ACYP2/MDH2/ME1/LDHB/ACAT2/ALDH9A1/GRHPR/DLD/ME3/ACACB/PDHB/ADH5/MDH1/ACYP1/ALDH2/AKR1A1	1.15760652350341
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	25/2494	78/9376	1.20494314560072	ZCCHC7/PAN3/C1D/LSM6/XRN2/XRN1/CNOT6L/LSM1/CNOT2/LSM5/LSM4/EXOSC8/DCP1A/LSM8/EXOSC7/TENT4B/CNOT4/LSM3/CNOT10/CNOT9/EXOSC1/EXOSC3/NUDT16/EXOSC5/EXOSC2	1.0941137017597
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	15/2494	44/9376	1.28162134577532	ADPRS/POLE4/POLB/APEX1/MPG/POLD3/RFC2/RFC4/PARP4/POLG2/UNG/OGG1/NTHL1/PARP3/POLE2	1.12714832845912
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	33/2494	106/9376	1.17038628557595	CREB1/CTNNB1/FOXO1/GSK3B/SOS1/TCF7L2/MAP2K1/CREB5/NFKB1/BRAF/BCL2/CREBBP/PDGFC/CASP9/GSTP1/IGF1R/SOS2/ZEB1/PIK3CB/BAD/TCF7/KRAS/CDKN1B/MAPK1/MDM2/PIK3CA/IGF1/PIK3R1/PDGFD/PDGFA/FOLR1/LEF1/PDGFRA	1.06199929778649
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	17/2494	51/9376	1.25314087142475	PLA2G6/PLA2G4C/PEDS1/CHPT1/PLA2G4A/PLD4/PAFAH1B1/AGPS/PLPP1/PLB1/CEPT1/LPCAT2/PAFAH1B3/SELENOI/PLAAT2/ENPP2/PLA2G7	1.0911877133728
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/2494	51/9376	1.25314087142475	ADCY3/ACTG1/SEC61G/ATP6V1D/ATP6V1G1/ATP6V0E1/PRKCA/PRKACB/KCNQ1/KDELR1/ATP6V1E1/ADCY9/ATP6V0A1/ATP6V0D1/ATP6V0B/SEC61B/SLC12A2	1.0911877133728
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/2494	31/9376	1.33398866958119	RBKS/PGLS/DERA/TKT/FBP1/TALDO1/PRPS2/PGM2/PGM1/IDNK/TKTL1	1.12124225586357
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	7/2494	18/9376	1.46199768332888	ACSL5/CBR4/OXSM/ACACB/ACSL1/MECR/MCAT	1.18103035094174
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	45/2494	149/9376	1.13539609155934	GAB2/PIK3R5/PLA2G4C/GNA12/ADCY3/PLCB1/SOS1/CYTH3/MAP2K1/FYN/LPAR1/PLA2G4A/RHEB/GNA13/PDGFC/PRKCA/RRAS/CYTH1/DNM3/GAB1/SYK/PIP5K1B/SOS2/PLPP1/PIK3CB/INSR/AGPAT4/KRAS/ADCY9/AGPAT3/MAPK1/PIK3CA/RALA/FCER1G/PTK2B/DGKH/PIK3R1/PIK3R6/RRAS2/SHC3/PDGFD/PDGFA/PDGFRA/FCER1A/PLCB4	1.00287205621319
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	10/2494	28/9376	1.34265093366938	GPHN/GCH1/PCBD2/PTS/PCBD1/QDPR/MOCS2/DHFR/AKR1B1/TH	1.09307034481325
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	13/2494	38/9376	1.28611826277804	ADA/CIITA/BLNK/IL2RG/BTK/CD3D/ORAI1/CD3E/UNG/LCK/IL7R/CD8A/ICOS	1.06386610309297
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	42/2494	139/9376	1.1359406460397	CREB1/NCOA1/NCOA2/ADCY3/HSPA8/NCOA3/KRT24/GNAQ/PLCB1/ESR1/SOS1/MAP2K1/CREB5/FOS/GNAI3/FKBP5/BCL2/KRT14/KRT17/ITPR1/CALM2/KRT10/PRKACB/SRC/OPRM1/SOS2/PIK3CB/EBAG9/KRAS/ADCY9/MAPK1/PIK3CA/PIK3R1/MMP2/ITPR2/SHC3/KCNJ6/ESR2/GNAI1/CALM3/CALM1/PLCB4	0.972003405373915
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2494	12/9376	1.56642608928094	VKORC1L1/COQ2/COQ5/COQ4/GGCX	1.18189718333861
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	37/2494	122/9376	1.14015276006678	CREB1/PPARG/RPTOR/RAB2A/FOXO1/FOXO3/CREB5/PPP2R5C/RHEB/TBC1D1/RAB10/PPP2R3C/RPS6KB2/IGF1R/FBP1/CAB39L/PPP2R5A/PIK3CB/GYS1/INSR/PPP2R5E/RAB8A/ADIPOR1/PPP2R2D/PPP2R2A/ACACB/PIK3CA/LEPR/IGF1/RAB14/PFKFB4/PPP2R3A/PIK3R1/PPP2R2B/CAB39/PFKFB3/LIPE	0.937979509676445
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	46/2494	154/9376	1.12294441725075	EPRS1/ADSS2/GPHN/IDO2/MTHFD1L/TPK1/PANK2/NME7/KYNU/PPCDC/GCH1/AFMID/NME3/PTS/VKORC1L1/NMNAT1/NME4/GUSB/CMPK1/COQ2/COQ5/PPCS/DLD/FECH/KMO/QPRT/OXSM/GCLC/COQ4/UROS/AK3/MMAB/CTPS2/MTHFD2L/MOCS2/ADSS1/DHFR/BCAT2/UMPS/PMM1/ALDH2/AKR1A1/GGCX/AK5/AK9/MTHFD1	0.926047242489548
NA	NA	hsa04518	Integrin signaling	46/2494	154/9376	1.12294441725075	ACTG1/CTNNB1/GSK3B/ITGAE/RAC1/PDGFC/ITGA4/RAC2/LIMS1/SRC/IGF1R/LAMA2/PARVB/ITGA6/TGFB1/VCL/PIK3CB/VEGFB/ICAM2/COL6A2/COL6A1/TLN2/CCND3/PIK3CA/IGF1/ITGA9/ICAM3/PIK3R1/PTK2/THBS1/PDGFD/ITGAD/PDGFA/VWF/COL1A1/COL6A3/ITGB4/ITGAV/ITGB5/ITGB8/COL1A2/VCAM1/ITGB6/LAMA1/PDGFRA/LAMB3	0.926047242489548
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	35/2494	115/9376	1.14417209999651	NACA/CREB1/PDE4D/GNA12/ADCY3/GNAQ/PDE4B/PLCB1/MMP24/MEF2C/AKAP13/MAP2K1/CREB5/PRKCB/FOS/PDE4A/BRAF/GNAI3/STK39/OXSR1/MEF2A/RUNX2/BCL2/GNA13/ITPR1/PRKCA/PRKACB/ARRB1/ADCY9/MAPK1/ITPR2/PRKCG/VDR/GNAI1/PLCB4	0.936435201970637
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	23/2494	73/9376	1.184475618196	SERINC5/CHMP4B/PIN1/APOBEC3G/CREBBP/TSG101/BICD1/PSIP1/PDCD6IP/RAN/MDFIC/CPSF6/NUP153/ELL2/CHMP6/AFF4/KAT2B/MLLT3/TRIM5/APOBEC3B/APOBEC3A/APOBEC3F/APOBEC3H	0.952500961166674
Human Diseases	Cancer: specific types	hsa05218	Melanoma	23/2494	73/9376	1.184475618196	MITF/MAP2K1/BRAF/PDGFC/POLK/IGF1R/DDB2/PIK3CB/BAD/CDK6/KRAS/BAX/MAPK1/MDM2/PIK3CA/IGF1/PIK3R1/PDGFD/PDGFA/FGF7/GADD45B/CDKN2A/PDGFRA	0.952500961166674
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	47/2494	158/9376	1.11830925867652	RPS6/WNT2B/LPIN2/RPTOR/MAPKAP1/TBC1D7/GSK3B/SOS1/RPS6KA3/MAP2K1/PRKCB/LAMTOR1/ATP6V1D/ATP6V1G1/BRAF/LAMTOR4/RHEB/PRKCA/RPS6KB2/EIF4B/IGF1R/RRAGD/CAB39L/SOS2/EIF4E2/LAMTOR5/SLC38A9/SEC13/RPS6KA2/DEPTOR/PIK3CB/RICTOR/INSR/ATP6V1E1/KRAS/LAMTOR2/RRAGA/MAPK1/PIK3CA/IGF1/PIK3R1/PRKCG/PRR5/CAB39/PRR5L/FZD6/WNT2	0.902828901433726
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	54/2494	184/9376	1.10330881071092	SSH2/CAMK2D/NFATC3/RASA1/PAK1/MYL12B/PPP3CA/NCK1/PPP3CC/GSK3B/ROBO1/MYL12A/FYN/DPYSL2/GNAI3/ABL1/SRGAP1/BMPR2/RAC1/LIMK2/PPP3CB/PRKCA/RRAS/RAC2/SRC/PIK3CB/NFATC2/ABLIM1/CFL1/KRAS/SSH1/UNC5B/MAPK1/SLIT2/PIK3CA/SRGAP2/EFNA5/CXCL12/PIK3R1/PTK2/PARD6A/MYL9/LRIG2/GNAI1/EPHA4/RHOD/ROBO2/TRPC1/SEMA4A/MYL5/PLXNA4/EPHB1/CFL2/SEMA6D	0.851957232818731
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	12/2494	36/9376	1.25314087142475	PRIM2/POLE4/RPA3/RPA2/POLA1/RNASEH2C/POLD3/RFC2/RNASEH2B/RFC4/PRIM1/POLE2	0.916044584749799
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	24/2494	78/9376	1.15674541977669	FCGR2C/EEF1A1/CYBA/TAB2/PRKCB/FOS/NFKB1/FCGR1A/TLR2/ITGA4/JAK2/IRAK4/STAT1/MAPK14/TGFB1/IFNGR1/JAK1/MAPK1/NCF2/HLA-DRB3/ELK1/CYBB/CR1L/TGFB2	0.836804329137577
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	31/2494	103/9376	1.1314767091505	RNGTT/PPP1CA/PPP2R5C/SMG6/PPP1CC/NXT1/PPP2R3C/ALYREF/WDR33/PPP2R5A/PYM1/HBS1L/CPSF6/PPP2R5E/MAGOH/CSTF3/PPP2R2D/PPP2R2A/MSI2/SRRM1/ETF1/PAPOLG/SSU72/CSTF1/PPP2R3A/PPP2R2B/BCL2L2-PABPN1/GSPT1/PELO/CLP1/CSTF2T	0.807669785179874
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	25/2494	82/9376	1.14616543118118	DPYD/NME7/DUT/MGST3/NME3/MGST2/GMPS/NME4/GUSB/GSTP1/GSTT1/CMPK1/HPRT1/CDA/RRM2B/ITPA/RRM1/CDADC1/GSTM1/UPB1/UMPS/GSTO1/MGST1/DPYS/GSTO2	0.800252045320263
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	21/2494	68/9376	1.16099816029058	PPARD/SOS1/TCF7L2/MAP2K1/NFKB1/BRAF/FCGR1A/RPS6KB2/SOS2/STAT5B/PIK3CB/BAD/TCF7/KRAS/MAPK1/PIK3CA/PIK3R1/RUNX1/FLT3/ZBTB16/LEF1	0.802091125227491
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/2494	54/9376	1.18352193412338	AHCYL2/MDH2/KYAT3/LDHB/SMS/SDSL/CISD1/SDS/GOT1/MTAP/GCLC/CBS/MPST/APIP/MDH1/BCAT2/TST	0.814154517181249
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	54/2494	187/9376	1.08560866936262	MAPK8/TRAF3/ATG5/TANK/NAMPT/ANTXR2/CYBA/RIPK1/VDAC2/GABARAPL2/PLCB1/TAB2/MCU/NEK7/VDAC3/NLRP1/NFKB1/PKN2/PYCARD/BCL2/TXN2/ERBIN/ITPR1/TBK1/IRAK4/STAT1/CARD16/VDAC1/RIPK2/MAPK14/CASP4/SUGT1/MFN1/MAP1LC3B/IL18/TP53BP1/JAK1/MAPK10/RBCK1/MAPK1/SHARPIN/PANX1/AIM2/NOD1/ITPR2/NLRC4/CASP5/CYBB/RNASEL/TRAF2/TRAF5/NLRP3/PLCB4/MEFV	0.711837647087861
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2494	37/9376	1.21927219922408	IDO2/GNAQ/PLCB1/PRKCB/PRKCA/HBB/IL18/FAS/PRKCG/NPPA/VCAM1/PLCB4	0.804471708291325
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/2494	44/9376	1.19617992272363	RAB11A/CREB1/ADCY3/CREB5/DCTN2/DCTN4/PRKACB/DYNLL1/DYNC1LI1/ADCY9/ARHGDIB/DYNC2LI1/DYNC2H1/DYNC1I1	0.785181504499997
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	23/2494	76/9376	1.13772000168826	ADCY3/CAMK2D/ACTG1/GNAQ/PLCB1/PRKCB/GNAI3/ITPR1/CALM2/PRKCA/PRKACB/KCNQ1/CA2/ADCY9/ATP1B1/ITPR2/PRKCG/GNAI1/CALM3/CALM1/MYLK4/KCNJ15/PLCB4	0.725669499744251
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	9/2494	27/9376	1.25314087142475	ACAT2/HADH/ECHS1/HADHA/HMGCL/ACSM5/ABAT/OXCT1/ACSM3	0.792935937864187
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/2494	62/9376	1.15208112372921	ATG5/ADCY3/HSPA8/RPTOR/FOXO1/FOXO3/PRKACB/RPS6KB2/IGF1R/CAT/PIK3CB/CRYAB/INSR/KRAS/ADCY9/SOD1/PIK3CA/IGF1/PIK3R1	0.723235223773689
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	26/2494	87/9376	1.12350560886357	COX7C/COX4I1/UQCRB/COX7A2/UQCRFS1/UQCRH/SLC8A1/COX7A2L/COX6C/COX5A/COX6B1/COX7B/UQCR10/UQCRC2/CACNA2D3/SLC9A7/COX5B/COX7A1/ATP1B1/COX6A1/COX8A/UQCRHL/CACNA1D/CACNB4/UQCR11/SLC8A2	0.696688039083339
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	49/2494	170/9376	1.08359828293787	PRKCE/ARPC2/MAPK8/PALS1/ARPC3/MAP3K5/ACTG1/RAP1A/MYL6/MYL12B/MYL12A/DLG1/RAB8B/RAC1/TIAM1/ARPC1A/ARHGEF18/PRKACB/SRC/RDX/ACTR3/RAPGEF2/NEDD4/DLG2/TUBA1A/RAB8A/ARPC5L/PPP2R2D/PPP2R2A/ARPC4/MAPK10/MSN/CD1D/NEDD4L/CLDN14/CACNA1D/PATJ/PPP2R2B/MYH10/PARD6A/ARPC5/MYH14/HCLS1/MYL6B/MYL9/RUNX1/ACTR3B/LLGL2/ACTR3C	0.662159876824391
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/2494	41/9376	1.19201204842842	MAP2K1/DAPK1/RPS6KA5/BRAF/RASSF1/SRC/KRAS/MAPK1/MDM2/MMP1/MMP2/THBS1/CDKN2A	0.741719636227935
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	21/2494	70/9376	1.12782678428228	SNTB1/CD86/ACTG1/DTNA/BID/FYN/SSPN/ABL1/RAC1/CASP9/RAC2/LAMA2/CAV1/PRF1/EIF4G3/SNTB2/SGCE/CD80/HLA-DRB3/SGCG/LAMA1	0.646198414518442
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	101/2494	362/9376	1.0488996796732	RPS6/PIK3R5/PHLPP1/IGF2/GNG7/CREB1/IL3RA/YWHAB/RPTOR/FOXO3/GSK3B/SOS1/MAP2K1/CREB5/LPAR1/PPP2R5C/C8orf44-SGK3/NFKB1/PKN2/RAC1/RHEB/BCL2/PDGFC/GNG2/PRKCA/CASP9/TLR2/ITGA4/JAK2/PPP2R3C/RPS6KB2/SYK/EIF4B/YWHAZ/IGF1R/IL2RG/LAMA2/PPP2R5A/GNB1/SOS2/EIF4E2/ITGA6/GNG5/PIK3CB/BAD/GYS1/BRCA1/PRL/VEGFB/INSR/COL6A2/PPP2R5E/CDK6/JAK1/KRAS/CDKN1B/IL7/PPP2R2D/PPP2R2A/YWHAQ/COL6A1/MAPK1/CCND3/MDM2/PIK3CA/EFNA5/IGF1/ITGA9/PPP2R3A/PIK3R1/PIK3R6/PTK2/PPP2R2B/YWHAH/THBS1/PDGFD/PDGFA/PHLPP2/IL7R/VWF/COL1A1/COL6A3/GNGT2/MTCP1/ITGB4/ITGAV/ITGB5/ITGB8/COL1A2/FGF7/PRLR/FLT3/GNG4/MAGI2/ITGB6/CSHL1/IL2RB/GNG11/LAMA1/PDGFRA/LAMB3	0.571186653743456
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/2494	110/9376	1.0936502150616	RPS6/CAMK2D/ELOB/RBX1/MAP2K1/PRKCB/CUL2/LDHB/NFKB1/BCL2/CREBBP/PRKCA/RPS6KB2/PGK1/IGF1R/EIF4E2/PIK3CB/INSR/IFNGR1/CDKN1B/VHL/ELOC/MAPK1/PDHB/PIK3CA/IGF1/PIK3R1/PRKCG/CYBB/PFKFB3/HIF1A/NPPA	0.594751440137036
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	13/2494	42/9376	1.16363080918013	ATG7/FTH1/ATG5/VDAC2/ACSL5/VDAC3/MAP1LC3B/SAT2/GCLC/GPX4/ACSL1/CP/CYBB	0.639782495530608
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	30/2494	103/9376	1.09497746046823	RAB7A/GNAL/GNAQ/PLCB1/PRKCB/NFKB1/PRKCA/COL3A1/TLR2/PRKACB/LAMA2/TGFB1/VCL/PIK3CB/SERPINB9/CD1D/PIK3CA/PRDX1/PIK3R1/PTK2/PRKCG/GNA15/IL1R1/COL1A1/COL1A2/C9/TGFB2/LAMA1/LAMB3/PLCB4	0.583452579464042
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/2494	78/9376	1.10854769395267	LY96/MAPK8/FOS/NFKB1/GNAI3/PYCARD/CALM2/IRAK4/MAPK14/TIRAP/C5/C1S/CFL1/MAPK10/MAPK1/NOD1/C1QB/C1QA/GNAI1/CALM3/CALM1/NLRP3/CFL2	0.579494956515449
Human Diseases	Infectious disease: viral	hsa05162	Measles	39/2494	136/9376	1.07806972026982	RACK1/MAPK8/TRAF3/EIF3H/HSPA8/BID/CBLB/TAB2/GSK3B/RAB9A/FOS/NFKB1/BCL2/CASP9/TLR2/TBK1/IRAK4/STAT1/IL2RG/STAT5B/PIK3CB/BAD/CSNK2A1/EIF2S1/CD3D/TRADD/CDK6/JAK1/CDKN1B/MAPK10/MSN/BAX/CD3E/CCND3/PIK3CA/FAS/CD3G/PIK3R1/IL2RB	0.552068058448529
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	31/2494	107/9376	1.08917851441591	SIK1/CREB1/SIK2/CAMK2D/GNAQ/PLCB1/FOXO1/PPP3CA/PPP3CC/PDE3B/CREB5/LDHB/PPP3CB/CREBBP/ITPR1/CALM2/PRKACB/FBP1/PYGL/GYS1/PHKB/PPP4R3B/ACACB/PDHB/PPARA/ITPR2/PHKG1/CALM3/CALM1/PPP4R3A/PLCB4	0.558485895785425
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	22/2494	75/9376	1.10276396685378	GPX1/CREB1/ADCY3/TG/GNAQ/PLCB1/CREB5/PRKCB/ITPR1/PRKCA/PRKACB/ADCY9/ATP1B1/PAX8/TTF1/TSHR/ITPR2/PRKCG/ASGR2/GPX7/DUOX1/PLCB4	0.53787727814094
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2494	18/9376	1.25314087142475	ZNF143/MMADHC/MMAB/PRDX1/MMUT/MTRR	0.647118076571938
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	65/2494	233/9376	1.04876596535548	DCN/SNTB1/ACTG1/DTNA/MYOM1/DIAPH2/FMNL2/CAPZA2/SSPN/PDLIM1/COL3A1/ITGA4/PDLIM5/ANK2/LAMA2/ITGA6/VCL/COL6A2/TMOD2/COL24A1/PDLIM2/FHL3/SNTB2/COL6A1/TLN2/ATP1B1/ANKRD23/SDC2/CAPZA1/NID1/SGCE/ANK3/DAAM1/TMOD3/ITGA9/CAPZB/MYH10/MYH14/THBS1/SPTBN2/MYL9/MYL11/SPTBN4/FBN2/COL1A1/COL6A3/ITGB4/ITGAV/ITGB5/COL5A2/SYNE2/ITGB8/SGCG/BGN/DIAPH1/NEBL/ACTN2/COL1A2/VCAN/MYL5/ITGB6/FBLN2/PDLIM4/COL5A1/LAMA1	0.453760779314475
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	29/2494	101/9376	1.07943817637578	CREB1/WNT2B/ADCY3/CAMK2D/CTNNB1/GNAQ/PLCB1/GSK3B/MITF/TCF7L2/MAP2K1/PRKCB/GNAI3/CREBBP/CALM2/PRKCA/PRKACB/TCF7/KRAS/ADCY9/MAPK1/PRKCG/GNAI1/CALM3/CALM1/FZD6/WNT2/LEF1/PLCB4	0.483180637066757
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	63/2494	226/9376	1.04798064026229	MAPK8/CREB1/PDE4D/RAP1B/ADCY3/CAMK2D/RAP1A/PDE4B/PAK1/VAV3/PDE3B/MAP2K1/PPP1CA/CREB5/POPDC2/FOS/PDE4A/NFKB1/BRAF/GNAI3/RAC1/PPP1R12A/ABCC4/TIAM1/CREBBP/CALM2/PPP1CC/RRAS/PRKACB/RAC2/ATP2B1/PIK3CB/BAD/PTGER2/VAV1/ORAI1/ATP2B4/VAV2/ADCY9/MAPK10/NFATC1/MAPK1/ATP1B1/PIK3CA/CAMK4/PPARA/CACNA1D/PIK3R1/TSHR/RRAS2/CNGA1/CNGB1/MYL9/GNAI1/PDE3A/CALM3/ADCY10/NPPA/CNGA4/CALM1/FXYD1/LIPE/ARAP3	0.439527689555555
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	19/2494	65/9376	1.09890814878786	GNAQ/PLCB1/MAP2K1/PRKCB/ITPR1/PRKCA/ARRB1/PIK3CB/KRAS/MAPK1/PIK3CA/CACNA1D/PIK3R1/ITPR2/PRKCG/KCNJ6/ESR2/TRPC1/PLCB4	0.481689430739997
Organismal Systems	Sensory system	hsa04744	Phototransduction	9/2494	29/9376	1.16671736305063	CALM2/GNB1/GNAT2/RGS9/CNGA1/CNGB1/CALM3/CALM1/PDE6G	0.541277829219946
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2494	15/9376	1.25314087142475	TPK1/THTPA/ACP1/NTPCR/AK5	0.590640613258863
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	20/2494	69/9376	1.08968771428239	CREB1/CAMK2D/PPP3CA/PPP3CC/PPP1CA/CREB5/PRKCB/FOS/PPP3CB/CALM2/PPP1CC/PRKCA/PRKACB/SLC18A2/CAMK4/CACNA1D/TH/PRKCG/CALM3/CALM1	0.450120894320463
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	29/2494	102/9376	1.06885544915641	RAB11A/RAP1B/ADCY3/GNAQ/RAP1A/PLCB1/PRKCB/RAC1/ITPR1/PRKCA/KCNQ1/ATP2B1/ATP2B4/RAB8A/CA2/ADCY9/SLC26A3/ATP1B1/CELA2B/CPB2/CD38/BST1/ITPR2/PRKCG/SLC12A2/KCNMA1/TRPC1/CPB1/PLCB4	0.42090238277622
Cellular Processes	Cell motility	hsa04814	Motor proteins	54/2494	194/9376	1.04643722252995	MYO1E/ACTG1/MYL6/KIF13B/DCTN3/MYL12B/MYL12A/CAPZA2/ACTR10/DNAI2/MYO1D/KIF2A/DCTN2/KIF1B/DCTN4/MYO18A/KIFAP3/DYNLL1/DNAH17/MYO9A/KIF13A/KIF9/DYNLT1/KIF16B/HOOK3/TUBA1A/DYNC1LI1/CAPZA1/MYO5A/TUBD1/CAPZB/DYNC2LI1/TUBB6/MYH10/DNAI3/DNAH1/MYH14/MYL6B/MYL9/DYNLT5/MYL11/MYO10/KIF22/STARD9/MYO9B/BICDL1/DYNC2H1/DNAI4/DNAL4/DNAH14/DNAH12/MYL5/DYNC1I1/MYO6	0.393436805811677
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	10/2494	33/9376	1.1392189740225	OGDH/BCKDHB/IDH3G/DLD/DLST/GOT1/IDH3B/PDHB/BCAT2/ACO1	0.4822683408736
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	19/2494	66/9376	1.08225802532138	SMAD3/STAT4/NFKB1/TLR2/STAT1/TLR5/IL2RG/TGFB1/RORA/SMAD2/IL18/IFNGR1/NFATC1/IL12RB1/HLA-DRB3/IL12RB2/IL21R/IL18R1/TGFB2	0.403693666223301
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/2494	19/9376	1.18718608871819	OGDH/BCKDHB/DLD/DLST/PDHB/GCSH	0.491652876140766
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/2494	23/9376	1.14417209999651	PDSS2/PMVK/ACAT2/FNTA/PDSS1/CHURC1-FNTB/RCE1	0.416721784191203
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/2494	23/9376	1.14417209999651	RPA3/RPA2/POLD3/RFC2/RFC4/MSH2/MLH1	0.416721784191203
Organismal Systems	Digestive system	hsa04970	Salivary secretion	26/2494	93/9376	1.05102137603366	ADCY3/GNAQ/PLCB1/PRKCB/GUCY1A1/ITPR1/CALM2/PRKCA/LYZ/PRKACB/ATP2B1/ATP2B4/ADCY9/ATP1B1/PRKG1/CD38/BST1/ITPR2/PRKCG/GUCY1B1/SLC12A2/CALM3/CALM1/KCNMA1/LPO/PLCB4	0.297663781651973
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/2494	93/9376	1.05102137603366	FHIT/TRAF3/NFKB1/BCL2/CASP9/POLK/DDB2/LAMA2/ITGA6/PIK3CB/CKS1B/ZBTB17/CDK6/MAX/CDKN1B/BAX/PIK3CA/PIK3R1/PTK2/TRAF1/ITGAV/TRAF2/TRAF5/GADD45B/LAMA1/LAMB3	0.297663781651973
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/2494	49/9376	1.0741207469355	ST6GAL1/B4GALT1/GALNT10/GALNT1/B3GLCT/GALNT7/OGT/GALNT2/GALNT3/B4GALT3/FUT10/XXYLT1/GXYLT2/COLGALT2	0.313143475534087
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/2494	31/9376	1.09144527511188	DPYD/HIBCH/ALDH9A1/ECHS1/HADHA/UPB1/ALDH2/ABAT/DPYS	0.306993368017793
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	30/2494	109/9376	1.0347034718186	CCL4L2/CCL3L1/LY96/MAPK8/TRAF3/TLR1/CD86/RIPK1/MAP2K4/TAB2/MAP2K1/FOS/NFKB1/RAC1/TLR2/TBK1/IRAK4/STAT1/TLR5/MAPK14/TIRAP/PIK3CB/JAK1/MAPK10/MAP2K6/MAPK1/PIK3CA/CD80/PIK3R1/CTSK	0.219378024284867
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	42/2494	154/9376	1.02529707662025	PIK3R5/CREB1/SLC8A1/ADCY3/CAMK2D/GNAQ/PLCB1/PPP1CA/CREB5/POPDC2/PPP2R5C/RPS6KA5/GNAI3/CACNA2D3/BCL2/CREM/CALM2/PPP1CC/PRKCA/PRKACB/PPP2R3C/KCNQ1/MAPK14/PPP2R5A/ATP2B1/PPP2R5E/ATP2B4/ADCY9/PPP2R2D/PPP2R2A/MAPK1/ATP1B1/CACNA1D/PPP2R3A/PIK3R6/PPP2R2B/CACNB4/GNAI1/CALM3/CALM1/SLC8A2/PLCB4	0.190543731639738
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	18/2494	65/9376	1.04107087779903	LPIN2/GK/ALDH9A1/GLA/PLPP1/AGPAT4/GPAT3/AGPAT3/LIPC/MBOAT1/MBOAT2/DGKH/AKR1B1/LCLAT1/ALDH2/AKR1A1/LPL/PLPP4	0.200017976167326
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/2494	32/9376	1.05733761026464	GALM/B4GALT1/GLA/PGM2/GLB1/MGAM/PGM1/AKR1B1/GANC	0.195580112330305
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/2494	32/9376	1.05733761026464	MAPK8/BID/BIRC6/BCL2/CASP9/MAPK10/BAX/BECN1/HTRA2	0.195580112330305
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	10/2494	36/9376	1.04428405952063	GBE1/GYG1/PYGL/GYS1/PGM2/MGAM/PGM1/ENPP1/GANC/GBA3	0.160251375790443
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/2494	36/9376	1.04428405952063	GALNT10/GALNT1/GCNT1/ST6GALNAC3/B4GALT5/GALNT7/GALNT2/ST6GALNAC2/GALNT3/ST6GALNAC4	0.160251375790443
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	31/2494	115/9376	1.01340957428263	GNG7/PLA2G4C/GNAQ/PLCB1/MAP2K1/PRKCB/PLA2G4A/BRAF/GNAI3/DUSP1/ITPR1/GNG2/PRKCA/PRKACB/HTR7/GNB1/SLC18A2/GNG5/KRAS/MAPK1/CACNA1D/ITPR2/PRKCG/KCNJ6/ALOX12/GNGT2/GNAI1/TRPC1/GNG4/GNG11/PLCB4	0.0870986647346815
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/2494	55/9376	1.02529707662025	ACER3/CERS6/SGMS1/GLA/PLPP1/SAMD8/B4GALT5/CERS5/SPTLC1/CERS4/SPTLC2/SGMS2/SPTLC3/GLB1/ACER2	0.113265319801158
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	42/2494	157/9376	1.00570541273579	STK3/PALS1/WNT2B/SMAD3/FBXW11/ACTG1/TPTEP2-CSNK1E/CTNNB1/YWHAB/GSK3B/TCF7L2/PPP1CA/BTRC/DLG1/BMPR2/RASSF1/PPP1CC/YWHAZ/TGFB1/SMAD2/SMAD1/DLG2/TCF7/PPP2R2D/PPP2R2A/YWHAQ/CCND3/TGFBR2/BMP5/PATJ/CTNNA3/PPP2R2B/BMPR1A/YWHAH/PARD6A/BMP6/LLGL2/FZD6/YAP1/TGFB2/WNT2/LEF1	0.0433981797793318
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	30/2494	112/9376	1.00698820025203	PIK3R5/LY96/MAPK8/HSPA8/TAB2/CIITA/NFKB1/GNAI3/BCL2/CASP9/TLR2/JAK2/IRAK4/STAT1/MAPK14/LAMA2/ITGA6/TGFB1/BAD/IFNGR1/JAK1/MAPK10/MAP2K6/MAPK1/PIK3R6/HLA-DRB3/GNAI1/TGFB2/LAMA1/LAMB3	0.0447869624139718
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	28/2494	105/9376	1.0025126971398	SNTB1/SLC8A1/ADCY3/ACTG1/DTNA/SSPN/CACNA2D3/ITGA4/PRKACB/LAMA2/ITGA6/TGFB1/ADCY9/SNTB2/SGCE/CACNA1D/IGF1/ITGA9/CACNB4/ITGB4/ITGAV/ITGB5/ITGB8/SGCG/ITGB6/TGFB2/LAMA1/SLC8A2	0.0155864795126056
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	19/2494	71/9376	1.00604267142551	MAPK8/LYN/MAP2K4/PAK1/ATP6V1D/ATP6V1G1/ATP6V0E1/NFKB1/RAC1/SRC/MAPK14/ATP6V1E1/MAPK10/ATP6V0A1/MAP3K14/ATP6V0D1/ATP6V0B/ADAM17/NOD1	0.0307663866807876
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/2494	14/9376	1.0741207469355	B4GALT1/FUT8/CHST2/B4GALT3	0.167069054673201
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/2494	41/9376	1.00862557943944	SDSL/GRHPR/DLD/SDS/GAMT/PIPOX/CBS/GCSH/SRR/BPGM/PSPH	0.0333195843512804
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	88/2494	333/9376	0.993481051219624	MAML3/MAML2/TRAF3/CREB1/PALS1/WNT2B/CTNNB1/FOXO1/HES1/GSK3B/SOS1/UBR4/TCF7L2/MAP2K1/CREB5/PPP2R5C/ATP6V1D/DLG1/ATP6V1G1/ATP6V0E1/NFKB1/RHEB/PSEN1/CREBBP/ATR/ITGA4/PRKACB/TBK1/PPP2R3C/STAT1/RPS6KB2/TBPL1/LAMA2/PPP2R5A/SOS2/ITGA6/PIK3CB/BAD/NFX1/COL6A2/ATP6V1E1/TRADD/PPP2R5E/CDK6/DLG2/TCF7/JAK1/KRAS/CDKN1B/PPP2R2D/PPP2R2A/BAX/CSNK1A1/COL6A1/MAPK1/ATP6V0A1/CCND3/MDM2/PIK3CA/FAS/RBPJ/ATP6V0D1/ATP6V0B/ITGA9/PATJ/PPP2R3A/PIK3R1/PTK2/PPP2R2B/RBL1/PARD6A/NOTCH2/THBS1/VWF/COL1A1/COL6A3/TBP/ITGB4/ITGAV/ITGB5/ITGB8/LLGL2/COL1A2/FZD6/ITGB6/LAMA1/WNT2/LAMB3	-0.0729155152010533
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	26/2494	99/9376	0.987323110819502	SNTB1/SLC8A1/ACTG1/DTNA/SSPN/CACNA2D3/ITGA4/LAMA2/ITGA6/TGFB1/SNTB2/SGCE/CACNA1D/IGF1/ITGA9/CACNB4/ITGB4/ACE/ITGAV/ITGB5/ITGB8/SGCG/ITGB6/TGFB2/LAMA1/SLC8A2	-0.0763313672300626
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	27/2494	103/9376	0.985479714421407	SLC8A1/COL3A1/SLC36A4/KCNQ1/COL15A1/COL6A2/COL24A1/COL14A1/COL13A1/KCNE3/COL6A1/ATP1B1/SLC16A10/PRCP/CELA2B/CPB2/SLC9A3/COL1A1/COL6A3/COL22A1/COL5A2/COL23A1/COL1A2/SLC36A3/CPB1/COL5A1/SLC8A2	-0.089199037683453
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	26/2494	100/9376	0.977449879711307	CSF2RA/IL3RA/CD37/CD9/FCGR1A/CD33/ITGA4/ITGA6/CD3D/FCER2/IL7/CD3E/CD7/CD1D/CD22/CD38/CD3G/HLA-DRB3/IL7R/IL1R1/CD44/CD2/CD5/CR1L/FLT3/CD8A	-0.136472460461844
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/2494	19/9376	0.989321740598489	ARSB/GUSB/HGSNAT/HPSE/GLB1	-0.0280469397212208
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/2494	23/9376	0.980718942854154	B4GALT1/POMK/RXYLT1/B4GALT3/LARGE1/FKTN	-0.0557308698084006
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	16/2494	62/9376	0.970173577877228	MAML3/MAML2/ATXN1/NUMB/HES1/PSEN1/CTBP2/CIR1/CREBBP/APH1B/KAT2B/PTCRA/NCOR2/RBPJ/ADAM17/NOTCH2	-0.141842186258047
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	23/2494	89/9376	0.971536181216943	GPHN/GNG7/PLCL1/ADCY3/GABARAPL2/PRKCB/GNAI3/GNG2/PRKCA/PRKACB/SRC/GNB1/GNG5/ADCY9/SLC38A1/CACNA1D/PRKCG/ABAT/KCNJ6/GNGT2/GNAI1/GNG4/GNG11	-0.162415313577613
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/2494	35/9376	0.966708672241952	GMDS/FBP1/PFKFB4/AKR1B1/PMM1/PFKFB3/FPGT/KHK/SORD	-0.118780454092546
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	52/2494	201/9376	0.972586944986375	H3-3A/H3-3B/CDK14/ETV6/PBX3/KDM6A/SUPT3H/CD86/PPARG/MEF2C/FOXO1/AFF1/FLI1/MITF/NFKB1/FUT8/GZMB/RUNX2/FCGR1A/POLK/LMO2/IGF1R/DDB2/ZEB1/NCOR1/ATF1/ZBTB17/LYL1/SMAD1/MAX/CDKN1B/SIN3A/BAX/PTCRA/MDM2/PRCC/TGFBR2/IGF1/BCL11B/PAX8/MLLT3/PTK2/BMP2K/RUNX1/PDGFA/TRAF1/MLF1/FLT3/H3C1/ZBTB16/GADD45B/IL2RB	-0.236498809289553
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/2494	109/9376	0.96572324036403	PRKCE/MAPK8/CREB1/FOXO1/GSK3B/RPS6KA3/PPP1CA/CREB5/PRKCB/TBC1D4/NFKB1/PTPN1/PPP1CC/RPS6KB2/PYGL/RPS6KA2/PIK3CB/GYS1/INSR/MAPK10/SLC27A5/PRKCQ/ACACB/OGT/PIK3CA/PPARA/PIK3R1/TRIB3	-0.216680562888106
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	37/2494	144/9376	0.96596275505658	LY96/MAPK8/TRAF3/MAP3K5/LPIN2/RIPK1/CTNNB1/MAP2K4/FOXO1/TAB2/FOXO3/GSK3B/TCF7L2/NFKB1/ALDH9A1/TBK1/IRAK4/IL17RA/MAPK14/ACADM/TIRAP/C5/TRADD/TCF7/ADIPOR1/MAPK10/MAP2K6/ACACB/C3AR1/ADH5/PPARA/FAS/MAP3K14/ALDH2/C1QB/C1QA/LEF1	-0.247778874996987
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/2494	59/9376	0.95578541040871	ADCY3/PDE3B/GNAI3/PRKACB/PIK3CB/INSR/ADCY9/PIK3CA/PRKG1/PLAAT2/PIK3R1/TSHR/GNAI1/NPPA/LIPE	-0.205083199794371
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	38/2494	148/9376	0.965257157719066	NCOA1/WNT2B/NCOA3/CTNNB1/ESR1/HES1/GSK3B/SOS1/TCF7L2/MAP2K1/FOS/BRAF/POLK/RPS6KB2/IGF1R/DDB2/SOS2/PIK3CB/BRCA1/CDK6/TCF7/KRAS/BAX/CSNK1A1/MAPK1/PIK3CA/FRAT2/IGF1/PIK3R1/SHC3/NOTCH2/FRAT1/ESR2/FGF7/FZD6/GADD45B/WNT2/LEF1	-0.256459586800259
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/2494	28/9376	0.939855653568565	ATP6V1D/ATP6V1G1/ATP6V0E1/ATP6V1E1/CA2/ATP6V0A1/ATP6V0D1	-0.191862899039438
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/2494	20/9376	0.939855653568565	GMDS/NANS/CYB5R4/CYB5R1/NPL	-0.162084404522836
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	13/2494	52/9376	0.939855653568565	VDAC2/STARD3NL/VDAC3/VAPA/VDAC1/VAPB/NPC2/LIPC/NPC1/TSPO/OSBPL5/LPL/APOC1	-0.261801347733136
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	14/2494	56/9376	0.939855653568565	EEF1A1/RAB1A/HSPA8/NFKB1/PYCARD/CASP9/TLR2/TLR5/HBS1L/IL18/SAR1B/BCL2L13/NLRC4/CR1L	-0.271742393205852
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/2494	12/9376	0.939855653568565	NCAM1/NPC1/NCAM2	-0.125496397475784
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	44/2494	173/9376	0.956153728485938	RAB11A/SLC25A5/TRAF3/SLC25A6/ACTG1/BID/NUP98/MAP2K1/PRKCB/CIITA/NFKB1/PYCARD/CREBBP/PRKCA/CASP9/NXT1/TBK1/JAK2/IRAK4/TNFSF10/STAT1/VDAC1/TNFRSF10B/CALCOCO2/PIK3CB/IL18/EIF2S1/IFNGR1/TRADD/CDK6/JAK1/KPNA1/DNAJC3/BAX/KPNA6/MAPK1/CCND3/PIK3CA/FAS/PIK3R1/HLA-DRB3/BCL2L2-PABPN1/RNASEL/NLRP3	-0.350402775930709
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	38/2494	150/9376	0.952387062282812	WNT2B/SMAD3/CTNNB1/GSK3B/SOS1/TCF7L2/MAP2K1/BRAF/BCL2/GAB1/POLK/RPS6KB2/DDB2/SOS2/TGFB1/PIK3CB/SMAD2/TCF7/KRAS/CDKN1B/BAX/CSNK1A1/MAPK1/PIK3CA/MLH1/TGFBR2/FRAT2/PIK3R1/CTNNA3/SHC3/FRAT1/ABCB1/FGF7/FZD6/GADD45B/TGFB2/WNT2/LEF1	-0.353867282780009
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	30/2494	119/9376	0.947753600237208	MAPK8/TRAF3/CREB1/MAP3K5/RIPK1/IL15/MAP2K4/TAB2/MAP2K1/CREB5/FOS/RPS6KA5/NFKB1/MAPK14/PIK3CB/TRADD/MAPK10/MAP2K6/MAPK1/PIK3CA/FAS/MAP3K14/PIK3R1/ADAM17/TRAF1/JUNB/TRAF2/TRAF5/VCAM1/IL18R1	-0.345279859720534
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	36/2494	143/9376	0.946428070726387	H3-3A/H3-3B/MACROH2A1/H2AZ1/H2AZ2/H2AJ/H4C3/H2AC20/H2AX/CD86/MACROH2A2/C7/SNRPD1/H2AC6/FCGR1A/C5/H2BC21/C1S/H4C5/H2BC4/H2BC18/CD80/H2BC12/H2AC17/HLA-DRB3/C1QB/H2BC15/H4C8/H2BC6/C1QA/H4C1/H2BC11/H2AC16/H3C1/C9/H2BC9	-0.388606818424959
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/2494	41/9376	0.916932344944941	RAD51B/BABAM2/RPA3/RPA2/UIMC1/RAD52/ABRAXAS1/POLD3/BRCA1/RAD51	-0.320880441587047
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	9/2494	37/9376	0.914454149418063	ADSS2/GLUD1/ASRGL1/NIT2/GOT1/ADSS1/ABAT/ASNS/DDO	-0.313852904282481
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2494	17/9376	0.884570026888061	CA5B/GLUD1/CA2/CA13	-0.286750946560198
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/2494	50/9376	0.902261427425822	CD86/IL15/ITGA4/TNFSF13B/TGFB1/IL15RA/CD80/CXCL12/MAP3K14/HLA-DRB3/CCL28/ICOS	-0.417138060279167
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/2494	50/9376	0.902261427425822	GYPC/TLR2/HBB/KLRB1/TGFB1/IL18/KLRC4-KLRK1/SDC2/THBS1/CR1L/VCAM1/TGFB2	-0.417138060279167
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2494	13/9376	0.867559064832521	XRCC4/XRCC5/POLM	-0.287649041848636
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	64/2494	254/9376	0.94725609178564	SLC25A5/CAMK1D/SLC25A6/GNAL/SLC8A1/ADCY3/CAMK2D/NFATC3/VDAC2/GNAQ/PLCB1/PPP3CA/ITPKB/PPP3CC/MCU/PRKCB/STIM1/VDAC3/PPP3CB/ITPR1/PDGFC/CALM2/PRKCA/PRKACB/HTR7/VDAC1/ATP2B1/NFATC2/VEGFB/HRH1/ORAI1/ATP2B4/PHKB/ORAI3/ADCY9/RYR1/NFATC1/CAMK1/CAMK4/CYSLTR1/MCOLN2/CYSLTR2/CD38/PTK2B/CACNA1D/STIM2/ITPR2/PRKCG/PDGFD/GNA15/PDE1B/PDGFA/CHRNA7/P2RX1/PHKG1/NTRK3/CALM3/PDE1C/CALM1/FGF7/MYLK4/SLC8A2/PDGFRA/PLCB4	-0.513003891972716
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/2494	110/9376	0.922767368958227	DCN/SMAD3/SMURF2/RBX1/CUL1/BMPR2/CREBBP/RPS6KB2/ACVR2A/TGFB1/LEMD3/NCOR1/SMAD2/SMAD1/SIN3A/MAPK1/TGFBR2/ACVR1/BMP5/SMURF1/BMPR1A/RBL1/BMP6/THBS1/TMEM53/THSD4/TGFB2	-0.490487058758506
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/2494	26/9376	0.867559064832521	PLA2G6/PLA2G4C/PLA2G4A/PLB1/ACAA1/PLAAT2	-0.407079878130676
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2494	22/9376	0.854414230516877	ALDH9A1/HNMT/ALDH2/AMDHD1/HAL	-0.411536265734706
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2494	39/9376	0.867559064832521	MTHFD1L/AHCYL2/ST20-MTHFS/DLD/CBS/GCSH/MTHFD2L/DHFR/MTHFD1	-0.498915953598232
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/2494	27/9376	0.835427247616502	ELOVL5/HACD4/HSD17B12/ACAA1/ACOT7/ELOVL7	-0.515506046193296
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	38/2494	156/9376	0.91575679065655	EIF3E/TRAF3/PIAS1/RIPK1/CTNNB1/YWHAB/BID/GSK3B/SOS1/MAP2K1/NFKB1/BRAF/CASP9/TBK1/STAT1/YWHAZ/SOS2/PIK3CB/BAD/EIF2S1/TRADD/CDK6/JAK1/KRAS/PPP2R2D/PPP2R2A/YWHAQ/BAX/MAPK1/PIK3CA/CLDN14/PPARA/FAS/PIK3R1/PPP2R2B/YWHAH/RNASEL/TRAF2	-0.638716698941535
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	41/2494	168/9376	0.917478138007408	PIAS1/CSF2RA/IL3RA/IL15/STAT4/SOS1/PTPN2/BCL2/CREBBP/JAK2/STAT1/IL2RG/SOS2/STAT5B/PIK3CB/PRL/IFNGR1/JAK1/IL7/STAM/STAM2/IL15RA/IL20RB/CCND3/IL12RB1/SOCS6/PIK3CA/LEPR/SOCS5/PIK3R1/IL19/PDGFA/IL7R/IL12RB2/PRLR/IL21R/CSHL1/IL2RB/CRLF2/IL6ST/PDGFRA	-0.649706980453562
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	44/2494	180/9376	0.918969972378152	TRAF3/SRSF9/BID/TAB2/PILRA/PPP1CA/POU2F1/SRSF4/NFKB1/EIF2B3/RHEB/BCL2/PPP1CC/CASP9/TLR2/TBK1/JAK2/IRAK4/STAT1/ALYREF/SYK/SRC/SRPK1/PIK3CB/BAD/C5/EIF2S1/IFNGR1/TRADD/JAK1/POU2F2/EIF2B1/BAX/PIK3CA/FAS/EIF2B2/PIK3R1/HLA-DRB3/CFP/SP100/HCFC2/RNASEL/TRAF2/TRAF5	-0.660783647394107
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/2494	23/9376	0.817265785711795	PREP/ATP6AP2/NLN/PRCP/ACE	-0.528183523808005
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2494	23/9376	0.817265785711795	GLUD1/CA2/ATP1B1/MDH1/SLC9A3	-0.528183523808005
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	21/2494	89/9376	0.8870547741546	ITGA4/CD47/LAMA2/ITGA6/COL6A2/COL6A1/MEPE/ITGA9/THBS1/VWF/COL1A1/COL6A3/ITGB4/ITGAV/ITGB5/CD44/ITGB8/COL1A2/ITGB6/LAMA1/LAMB3	-0.644468488665837
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	8/2494	36/9376	0.835427247616502	FGGY/CRYL1/GUSB/XYLB/AKR1B1/AKR1A1/SORD/DHDH	-0.595541833168912
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	53/2494	217/9376	0.918199993348091	CREB1/ADCY3/ESR1/KPNA3/SOS1/RPS6KA3/MAP2K1/CREB5/PRKCB/FOS/MGST3/NFKB1/GNAI3/MGST2/BCL2/PRKCA/PRKACB/JAK2/PTGES3/RPS6KB2/SRC/GSTT1/ARRB1/SOS2/STAT5B/RPS6KA2/PIK3CB/BAD/AIP/KRAS/ADCY9/KPNA1/KPNA6/MAPK1/CCND3/PIK3CA/PPARA/CACNA1D/NR1I3/EPHX1/PIK3R1/GSTM1/PRKCG/NOTCH2/VDR/ESR2/CHRNA7/GSTO1/GNAI1/KPNA4/MGST1/FGF7/GSTO2	-0.73389800145078
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/2494	15/9376	0.751884522854852	ST6GALNAC3/GLB1/ST6GALNAC4	-0.578915118507789
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2494	24/9376	0.78321304464047	EXT1/HS2ST1/GLCE/HS3ST3B1/HS3ST2	-0.640122431775831
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/2494	155/9376	0.897410559536436	FCGR2C/RAB7A/CYBA/ACTG1/SEC61G/STX18/CLEC7A/ATP6V1D/ATP6V1G1/ATP6V0E1/STX12/MSR1/VAMP3/RAC1/FCGR1A/CTSS/TLR2/ATP6V1E1/PIK3C3/TUBA1A/DYNC1LI1/CORO1A/NCF2/ATP6V0A1/STX7/MARCO/ATP6V0D1/ATP6V0B/HLA-DRB3/SEC61B/TUBB6/THBS1/CYBB/DYNC2H1/ITGAV/ITGB5/DYNC1I1	-0.775275442999733
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/2494	37/9376	0.812848132816056	GMDS/NANS/GALK2/PGM2/UXS1/PGM1/PMM1/FPGT	-0.686627775140416
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/2494	50/9376	0.827072975140337	SMS/ALDH9A1/ODC1/SAT2/GOT1/P4HA3/GAMT/LAP3/AZIN2/ALDH2/L3HYPDH	-0.738034552991464
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	38/2494	160/9376	0.892862870890136	JAML/PTPRM/CD86/VSIR/CD99/ITGA4/CD58/NEGR1/ALCAM/ITGA6/ICAM2/NCAM1/CADM3/CD22/SDC2/CLDN14/CD80/ITGA9/ICAM3/CD226/HLA-DRB3/PTPRS/CD6/NLGN3/ITGAV/SELL/ITGB8/CADM1/CD2/PDCD1LG2/NCAM2/VCAN/NRXN3/CNTNAP2/VCAM1/CD8A/ICOS/PTPRD	-0.822820856710232
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	14/2494	63/9376	0.835427247616502	PLA2G6/PLA2G4C/PTGR3/TBXAS1/PLA2G4A/PTGES3/PTGDS/PLB1/PTGR1/LTA4H/GPX4/PLAAT2/CBR3/ALOX12	-0.788968991027419
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/2494	63/9376	0.835427247616502	WNT2B/CTNNB1/GSK3B/TCF7L2/PTCH2/POLK/DDB2/SUFU/TCF7/BAX/FZD6/GADD45B/WNT2/LEF1	-0.788968991027419
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/2494	38/9376	0.791457392478791	GALK2/GNPDA1/PGM2/UXS1/PGM1/PMM1/GNPDA2/FPGT	-0.775418559578455
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	17/2494	76/9376	0.840923479508716	ACSL5/PPARG/PPARD/ME1/GK/DBI/ACADM/ME3/SLC27A5/FABP5/ACAA1/ACSL1/PPARA/MMP1/FABP3/LPL/SORBS1	-0.838200534641766
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/2494	61/9376	0.801188425992875	FTH1/SLC8A1/ATOX1/ATP2B1/ATP2B4/CYBRD1/SLC26A3/ATP1B1/MT2A/MT1X/VDR/SLC9A3/SLC8A2	-0.937759948498978
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/2494	95/9376	0.831030262102731	CCL3L1/CD86/IL15/FOS/ATP6V1D/ATP6V1G1/ATP6V0E1/TLR2/TNFSF13B/TGFB1/IL18/ATP6V1E1/ATP6V0A1/CD80/CXCL12/MMP1/ATP6V0D1/ATP6V0B/HLA-DRB3/CTSK/TGFB2	-0.996437068430895
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2494	17/9376	0.663427520166046	SLC27A5/AKR1D1/CYP7B1	-0.836112792687786
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2494	17/9376	0.663427520166046	FMO5/GGT7/FMO4	-0.836112792687786
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/2494	83/9376	0.815296470565502	CCL4L2/RIPK1/POLR2L/POLR1D/NFKB1/PYCARD/TBK1/POLR3GL/IL18/POLR3K/POLR3F/AIM2/ZDHHC1/POLR3C/POLR1C/NLRP3/POLR3B/MEFV	-1.01744935438192
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/2494	79/9376	0.808989676489397	CLTA/ATP6V1D/ATP6V1G1/ATP6V0E1/DNM3/SLC18A2/AP2S1/ATP6V1E1/UNC13B/RAB3A/ATP6V0A1/CLTB/ATP6V0D1/SLC1A2/ATP6V0B/SYT1/STXBP1	-1.02630276495262
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/2494	75/9376	0.802010157711842	SDSL/TKT/PGK1/IDH3G/SDS/ENO4/TALDO1/PRPS2/GOT1/IDH3B/CBS/BCAT2/ACO1/TKTL1/PSPH/ASNS	-1.03629940269855
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/2494	67/9376	0.785550994027457	GALM/LDHB/ALDH9A1/PGK1/FBP1/DLD/ENO4/PGM2/PDHB/ADH5/PGM1/ALDH2/AKR1A1/BPGM	-1.06044085778066
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/2494	18/9376	0.626570435712376	MANBA/FUCA2/GLB1	-0.954618746537484
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/2494	46/9376	0.735539207140616	EPRS1/FTH1/BLVRB/HCCS/GUSB/FECH/UROS/MMAB/CP	-1.08237042813565
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/2494	28/9376	0.671325466834689	B4GALT1/ST3GAL4/ST3GAL6/B4GALT3/B3GNT5	-1.0484850616079
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/2494	86/9376	0.786855896010891	CREB1/ADCY3/CAMK2D/GNAQ/PLCB1/CREB5/PRKCB/KCNMB4/PRKCA/PRKACB/ADCY9/RAB3A/ATP1B1/CACNA1D/TRPM4/PRKCG/KCNMA1/PLCB4	-1.19533936212285
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/2494	47/9376	0.719889436775922	PRKCE/MAPK8/PIK3CB/INSR/MAPK10/MAPK1/PIK3CA/CACNA1D/PIK3R1	-1.15887714472563
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/2494	65/9376	0.751884522854852	CREB1/PDE8A/ADCY3/GNAQ/PLCB1/CREB5/ITPR1/PRKACB/ORAI1/ADCY9/CACNA1D/ITPR2/PLCB4	-1.20833929669603
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/2494	52/9376	0.722965887360434	PLA2G4C/ADCY3/PLA2G4A/PRKACB/IGF1R/INSR/ADCY9/IGF1/BMP6/HSD17B2	-1.20589728478925
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/2494	29/9376	0.648176312805907	STK3/TPTEP2-CSNK1E/PAK1/RASSF1/YAP1	-1.1422587197156
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/2494	70/9376	0.751884522854852	MAPK8/ACSL5/NFKB1/APPL1/JAK2/TRADD/ADIPOR1/MAPK10/PRKCQ/ACACB/LEPR/ACSL1/PPARA/TRAF2	-1.25428977071522
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/2494	48/9376	0.704891740176423	PLCB1/PRKCB/PIK3CB/ATP1B1/PIK3CA/MGAM/CACNA1D/PIK3R1/PLCB4	-1.23391215901654
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	34/2494	155/9376	0.824647541195644	CREB1/PDE8A/RAP1B/WNT2B/ADCY3/CAMK2D/CTNNB1/GNAQ/RAP1A/PLCB1/GSK3B/TCF7L2/MAP2K1/CREB5/BRAF/GNAI3/ITPR1/PRKACB/AIP/CDK6/ORAI1/TCF7/CDKN1B/ADCY9/MAPK1/CACNA1D/ITPR2/ASH2L/GNAI1/FZD6/CDKN2A/WNT2/LEF1/PLCB4	-1.32515056682586
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/2494	71/9376	0.741294599997741	MAP2K1/LDHB/PIK3CB/SCO2/KRAS/SIRT3/MAPK1/PDHB/PIK3CA/PIK3R1/NTRK3/HIF1A/FLT3/PDGFRA	-1.31720390079147
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	5/2494	30/9376	0.626570435712376	PLA2G6/PLA2G4C/PLA2G4A/PLB1/PLAAT2	-1.23319843684653
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/2494	49/9376	0.690506194458537	CREB1/CREB5/NFKB1/GNAI3/PRKACB/SLC18A2/TH/RGS9/GNAI1	-1.30754167936081
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	14/2494	72/9376	0.730998841664439	MAPK8/TRAF3/ATG5/TANK/RIPK1/RNF125/PIN1/NFKB1/TBK1/MAPK14/AZI2/TRADD/MAPK10/TRAF2	-1.37931060735517
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	19/2494	94/9376	0.759883294374584	MAPK8/TRAF3/TAB2/GSK3B/FOS/USP25/NFKB1/S100A9/TBK1/IL17RA/MAPK14/TRADD/MAPK10/MAPK1/MAPK6/MMP1/TRAF2/TRAF5/TRAF3IP2	-1.408451996134
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/2494	45/9376	0.668341798093201	CD86/KLRD1/GZMB/PRF1/CD80/FAS/HLA-DRB3/KLRC1	-1.34248497149667
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/2494	26/9376	0.578372709888347	CUBN/BTD/PLB1/SLC19A2	-1.29594362693208
NA	NA	hsa04981	Folate transport and metabolism	5/2494	31/9376	0.606358486173267	ST20-MTHFS/ABCC4/DHFR/MTHFD1/FOLR1	-1.32150440767376
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/2494	100/9376	0.751884522854852	CCL4L2/CCL3L1/CX3CR1/CXCL14/TNFSF10/TNFRSF10B/IL2RG/IL18/IL20RB/CXCL12/IL19/TNFRSF10D/XCL2/XCL1/CCL28/CCR2/CCR3/IL18R1/IL2RB/IL6ST	-1.5015853224358
NA	NA	hsa04081	Hormone signaling	48/2494	219/9376	0.823983038745043	IGF2/GNG7/GNA12/ADCY3/GNAQ/PLCB1/ESR1/GNAI3/GNA13/GNG2/APPL1/PRKACB/JAK2/SRC/OPRM1/IGF1R/GNB1/STAT5B/GNG5/PIK3CB/PRL/INSR/SMAD1/ADIPOR1/ADCY9/SLC16A10/PIK3CA/LEPR/PRKG1/ACVR1/IGF1/PIK3R1/TSHR/RAMP1/BMPR1A/GNA15/ESR2/THRB/GNGT2/GNAI1/ITGAV/NPPA/PRLR/PENK/GNG4/CSHL1/GNG11/PLCB4	-1.58663305558247
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/2494	79/9376	0.713814420431821	GSTK1/AKR7A2/MGST3/MGST2/GSTP1/GSTT1/HSD11B1/ADH5/EPHX1/GSTM1/CBR3/GSTO1/MGST1/GSTO2/DHDH	-1.53768155669391
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/2494	17/9376	0.44228501344403	MYH10/MYH14	-1.38547463881537
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/2494	39/9376	0.578372709888347	CD86/GZMB/PRF1/CD80/FAS/HLA-DRB3	-1.58830486392358
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/2494	44/9376	0.598089961361814	CD86/GZMB/PRF1/ICA1/CD80/FAS/HLA-DRB3	-1.60858626321386
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	29/2494	144/9376	0.757105943152455	WNT2B/SMAD3/JARID2/CTNNB1/PCGF5/GSK3B/MAP2K1/BMPR2/KAT6A/JAK2/IGF1R/MAPK14/ACVR2A/PIK3CB/SMAD2/SMAD1/TCF7/JAK1/KRAS/MAPK1/PIK3CA/ACVR1/IGF1/PIK3R1/BMPR1A/ESRRB/FZD6/IL6ST/WNT2	-1.76818118649682
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/2494	30/9376	0.501256348569901	NFKB1/ABCC4/DHFR/FOLR1	-1.64703052503097
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	16/2494	88/9376	0.683531384413501	C7/CLU/C5/C1S/C3AR1/CPB2/SERPINB2/C1QB/VWF/C1QA/PROS1/F2RL2/CR1L/PROCR/SERPIND1/C9	-1.79550826479172
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/2494	31/9376	0.485086788938614	ALDH9A1/GUSB/ALDH2/AKR1A1	-1.72862885159665
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/2494	20/9376	0.375942261427426	EBP/CYP2R1	-1.68178778132894
NA	NA	hsa03272	Virion - Hepatitis viruses	7/2494	48/9376	0.548249131248329	CD9/CHMP4B/SLC10A1/TSG101/PDCD6IP/CLDN14/CD63	-1.88886915646554
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	12/2494	73/9376	0.617987279058782	GSTK1/MGST3/MGST2/GSTP1/GSTT1/ADH5/GSTM1/FMO5/GSTO1/FMO4/MGST1/GSTO2	-1.97244214402258
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/2494	54/9376	0.556951498411001	CD86/TG/GZMB/PRF1/CD80/FAS/TSHR/HLA-DRB3	-1.96548679928673
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	11/2494	70/9376	0.590766410814526	GSTK1/MGST3/MGST2/GSTP1/GSTT1/HSD11B1/EPHX1/GSTM1/GSTO1/MGST1/GSTO2	-2.06878470724393
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/2494	23/9376	0.326906314284718	GLUD1/GOT1	-1.94554148580682
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/2494	16/9376	0.234963913392141	GOT1	-1.84365865626301
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/2494	16/9376	0.234963913392141	GLA	-1.84365865626301
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2494	37/9376	0.406424066408028	GSTZ1/GOT1/ADH5/TH	-2.17772725857216
Genetic Information Processing	Transcription	hsa03040	Spliceosome	48/2494	243/9376	0.742601997881335	U2AF1/HSPA8/SRSF9/LSM6/SF3B6/SF3B5/CDC40/TXNL4A/SNRNP40/SRSF4/SNRPD1/BCAS2/LSM5/HNRNPA1/LSM4/SNRPE/RBMX2/THOC7/PRPF18/ALYREF/PPIH/LSM8/PRPF40B/PHF5A/LSM3/MAGOH/WBP11/SNIP1/SNRPA1/SMNDC1/PQBP1/SNRPC/SNRPG/RP9/USP39/DHX8/U2AF1L4/HNRNPA1L3/PLRG1/SNRPD2/SNRPB2/SYF2/BUD31/YJU2/SF3A1/THOC5/PPIL1/HNRNPC	-2.44724871005152
Human Diseases	Immune disease	hsa05310	Asthma	3/2494	32/9376	0.352445870088212	FCER1G/HLA-DRB3/FCER1A	-2.20882434554855
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2494	66/9376	0.512648538310126	HSD17B11/HSD17B12/DHRS9/SRD5A1/HSD11B1/HSD11B2/AKR1D1/HSD17B2/CYP7B1	-2.39175080534957
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	60/2494	298/9376	0.756930727706226	CCL4L2/CCL3L1/CSF2RA/IL3RA/IL15/CX3CR1/TNFSF8/RELL1/BMPR2/CXCL14/TNFSF10/EDA/IL17RA/TNFRSF10B/IL16/IL2RG/TNFSF13B/ACVR2A/TGFB1/PRL/IL18/TNFSF12/IFNGR1/IL7/IL15RA/IL20RB/IL12RB1/LEPR/TGFBR2/CXCL12/FAS/IL1RL2/ACVR1/BMP5/IL19/BMPR1A/TNFRSF10D/BMP6/XCL2/IL7R/IL1R1/IL12RB2/TNFSF15/IL1RL1/IL1RAP/XCL1/IL32/CCL28/CCR2/PRLR/IL21R/CCR3/CSHL1/IL18R1/TNFRSF8/IL2RB/CRLF2/TGFB2/CD27/IL6ST	-2.56696313844556
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/2494	45/9376	0.417713623808251	ABCB7/ABCC4/ABCD3/ABCA5/ABCB1	-2.35697686549105
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/2494	90/9376	0.543027710950726	ADCY3/SLC10A1/ABCC4/PRKACB/CA2/ADCY9/SLC27A5/ATP1B1/EPHX1/SLC51A/SLC9A3/ABCB1/SLC22A1	-2.62224525844169
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/2494	82/9376	0.504312789719718	CREB1/HSPA8/KLRD1/CIITA/NFYC/CTSS/NFYB/NFYA/HLA-DRB3/KLRC1/CD8A	-2.7138749611336
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	14/2494	99/9376	0.531635521210501	FCGR2C/KRT24/FPR1/KRT14/KRT17/FCGR1A/KRT10/C5/C1S/C3AR1/FPR2/HLA-DRB3/C1QB/C1QA	-2.82016356844053
NA	NA	hsa04082	Neuroactive ligand signaling	34/2494	199/9376	0.642313411484044	GNG7/GNAL/ADCY3/GNAQ/PLCB1/PRKCB/GNAI3/GNG2/PRKCA/PRKACB/HTR7/OPRM1/GNB1/SLC18A2/GNG5/HRH1/GRIK1/P2RY13/ADCY9/P2RY12/SLC1A2/PRKCG/CHRNA7/P2RX1/GNGT2/GNAI1/P2RY6/TAC4/GRIK2/PENK/GNG4/GNG11/P2RY2/PLCB4	-3.07012004741792
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2494	26/9376	0.144593177472087	HES1	-2.62923925013418
NA	NA	hsa04382	Cornified envelope formation	36/2494	217/9376	0.623683014349647	S100A4/KRT6A/KRT24/SPRR3/PPP2R5C/KRT5/KRT14/KRT17/KRT10/S100A9/PPP2R3C/PPP2R5A/ITGA6/S100A16/PPP2R5E/SPTLC1/S100A6/PPP2R2D/PPP2R2A/SPTLC2/CLDN14/SPTLC3/S100A14/S100A12/DST/EVPL/PPP2R3A/PPP2R2B/PADI2/PPL/ITGB4/S100A2/KAZN/KRT86/HAL/LAMB3	-3.37626236212941
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/2494	68/9376	0.331713760083023	ALDH1A2/DHRS4L2/DHRS9/PNPLA4/ADH5/CYP26B1	-3.32939495197711
NA	NA	hsa04519	Cadherin signaling	75/2494	404/9376	0.697912614036063	ARPC2/CDH23/MAPK8/STK3/PALS1/KRT6A/ARPC3/WNT2B/MYO1E/BRK1/ACTG1/KRT24/CTNNB1/YWHAB/VAV3/GSK3B/TCF7L2/MAP2K1/PPP1CA/RERE/MYO1D/TAOK3/NFKB1/KRT5/RAC1/PSEN1/KRT14/KRT17/ERBIN/CREBBP/KRT10/SHOC2/PPP1CC/ARPC1A/RRAS/EVL/RAC2/APH1B/YWHAZ/IGF1R/MAPK14/ACTR3/VCL/ANKRD6/VAV1/TCF7/KRAS/CYFIP2/ARPC5L/VAV2/ARPC4/MAPK10/YWHAQ/CSNK1A1/MAPK1/DAAM1/PTK2B/TMC1/DSC3/CTNNA3/PTK2/YWHAH/ARPC5/RRAS2/ACTR3B/CDH11/PRICKLE3/LHFPL5/FZD6/YAP1/KRT86/ACTR3C/WNT2/LEF1/PDGFRA	-3.73641554172996
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/2494	183/9376	0.554668910302759	TCOF1/PWP2/NOP10/XRN2/XRN1/UTP6/NXT1/EFL1/POP4/UTP18/RAN/RPP25L/RPP30/CSNK2A1/RRP7A/NMD3/IMP4/RIOK1/REXO2/RPP38/RCL1/NOB1/IMP3/EIF6/NHP2/POP7/SBDS	-3.66232143489838
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/2494	43/9376	0.174856865780198	ACAT2/PLPP1	-3.26459577239322
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/2494	86/9376	0.305999515115347	PLCB1/PRKACB/PKD2L1/PDE1B/PDE1C/PKD1L3/PLCB4	-3.89204337060788
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2494	41/9376	0.0916932344944941	CHRNA7	-3.50868067503199
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	45/2494	323/9376	0.523758568552141	PRKCE/RPTOR/SOS1/PDCD4/MAP2K1/PRKCB/RPS6KA5/HDAC4/NFKB1/ABL1/BMPR2/BCL2/RASSF1/CREBBP/PRKCA/CCNG1/SOS2/RDX/SLC7A1/ZEB1/PIK3CB/BRCA1/CDK6/KRAS/CDKN1B/STMN1/MAPK1/MDM2/PIK3CA/EFNA5/CDC25B/PIK3R1/PRKCG/NOTCH2/THBS1/ZEB2/PDGFA/ZFPM2/RECK/TP63/ABCB1/CD44/TGFB2/CDKN2A/PDGFRA	-5.24334826331894
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	39/2494	370/9376	0.396263464747827	P2RY8/UTS2/FPR1/NR3C1/LPAR1/GZMA/HTR7/OPRM1/PTGER2/PRL/C5/HRH1/GRIK1/P2RY13/S1PR4/TSPO/C3AR1/LEPR/CYSLTR1/CYSLTR2/FPR2/TSHR/TMEM97/CHRNA7/P2RX1/THRB/P2RY6/NPW/TAC4/SPX/F2RL2/GRIK2/PRLR/PENK/CALCRL/CSHL1/S1PR5/P2RY2/PTGDR	-7.1327807943609
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	20/2494	449/9376	0.167457577473241	GNG7/GNAL/SLC8A1/ADCY3/CAMK2D/GRK3/CALM2/PRKACB/ARRB1/GNB1/NCALD/PDE2A/PRKG1/CNGB1/PDE1B/CALM3/PDE1C/CNGA4/CALM1/SLC8A2	-10.8831171506008