ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 119/5150 175/18639 0.68 2.46107184466019 8.0406263942111e-29 1.10156581600692e-25 GO:0140101 catalytic activity, acting on a tRNA 78/5150 139/18639 0.561151079136691 2.03093106097646 1.38885380797583e-12 9.51364858463443e-10 GO:0019787 ubiquitin-like protein transferase activity 190/5150 479/18639 0.396659707724426 1.43560005675254 5.38138478186634e-09 2.45749905038563e-06 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 41/5150 68/18639 0.602941176470588 2.18217875499714 1.69542367502779e-08 5.80682608697018e-06 GO:0016755 aminoacyltransferase activity 193/5150 496/18639 0.389112903225806 1.40828648606326 2.31111061821431e-08 6.33244309390722e-06 GO:0004842 ubiquitin-protein transferase activity 177/5150 449/18639 0.394209354120267 1.42673167989275 3.00799526550406e-08 6.86825585623427e-06 GO:0000287 magnesium ion binding 101/5150 230/18639 0.439130434782609 1.58931110173069 7.56098945707958e-08 1.47979365088557e-05 GO:0019843 rRNA binding 38/5150 65/18639 0.584615384615385 2.11585362210605 1.77246294297829e-07 3.03534278985033e-05 GO:0009055 electron transfer activity 58/5150 116/18639 0.5 1.80961165048544 2.52994076370244e-07 3.85113205141371e-05 GO:0016651 oxidoreductase activity, acting on NAD(P)H 47/5150 88/18639 0.534090909090909 1.93299426301853 2.85497125995491e-07 3.91131062613823e-05 GO:0060589 nucleoside-triphosphatase regulator activity 186/5150 490/18639 0.379591836734694 1.37382762036854 3.1735938703703e-07 3.95256691127938e-05 GO:0043021 ribonucleoprotein complex binding 80/5150 177/18639 0.451977401129944 1.63580714168175 3.94812828480217e-07 4.50744645848248e-05 GO:0030695 GTPase regulator activity 185/5150 489/18639 0.378323108384458 1.36923580916076 4.44015466546286e-07 4.67923991668009e-05 GO:0140098 catalytic activity, acting on RNA 151/5150 387/18639 0.390180878552972 1.4121517272522 6.2852438017207e-07 5.99750638049454e-05 GO:0003954 NADH dehydrogenase activity 28/5150 44/18639 0.636363636363636 2.30314210061783 6.56661282535899e-07 5.99750638049454e-05 GO:0016874 ligase activity 75/5150 167/18639 0.449101796407186 1.62539968606476 1.2139217761953e-06 0.000103942052086722 GO:0005085 guanyl-nucleotide exchange factor activity 97/5150 230/18639 0.421739130434783 1.52636808780076 1.29466808185337e-06 0.000104335016008183 GO:0004812 aminoacyl-tRNA ligase activity 26/5150 41/18639 0.634146341463415 2.29511721524982 1.82026501146564e-06 0.000124688153285396 GO:0008137 NADH dehydrogenase (ubiquinone) activity 26/5150 41/18639 0.634146341463415 2.29511721524982 1.82026501146564e-06 0.000124688153285396 GO:0016875 ligase activity, forming carbon-oxygen bonds 26/5150 41/18639 0.634146341463415 2.29511721524982 1.82026501146564e-06 0.000124688153285396 GO:0032182 ubiquitin-like protein binding 57/5150 120/18639 0.475 1.71913106796116 2.65688553511936e-06 0.000173330151576834 GO:0015078 proton transmembrane transporter activity 80/5150 185/18639 0.432432432432432 1.56506953555497 3.38694389842e-06 0.000210914233674336 GO:0043022 ribosome binding 53/5150 112/18639 0.473214285714286 1.71266816920943 6.7422103048359e-06 0.000401601222505443 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 24/5150 39/18639 0.615384615384615 2.227214339059 9.69419832611583e-06 0.000553377154449112 GO:0043130 ubiquitin binding 48/5150 100/18639 0.48 1.73722718446602 1.11500116749283e-05 0.000598373118307354 GO:0019902 phosphatase binding 80/5150 190/18639 0.421052631578947 1.52388349514563 1.13559861868549e-05 0.000598373118307354 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 13/5150 16/18639 0.8125 2.94061893203883 1.24954207080009e-05 0.000634026902591156 GO:0019210 kinase inhibitor activity 44/5150 90/18639 0.488888888888889 1.76939805825243 1.425781510889e-05 0.000697614524970687 GO:0031625 ubiquitin protein ligase binding 117/5150 302/18639 0.387417218543046 1.40214942454832 1.61122294701784e-05 0.000761163943936012 GO:0003953 NAD+ nucleosidase activity 10/5150 11/18639 0.909090909090909 3.29020300088261 2.12358841607903e-05 0.000969772043342759 GO:0035091 phosphatidylinositol binding 110/5150 284/18639 0.387323943661972 1.40181184192534 2.87718297297371e-05 0.00120323074574139 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 31/5150 58/18639 0.53448275862069 1.93441245396719 2.88623340889064e-05 0.00120323074574139 GO:0004860 protein kinase inhibitor activity 41/5150 84/18639 0.488095238095238 1.76652565880721 2.89829303718729e-05 0.00120323074574139 GO:0070402 NADPH binding 13/5150 17/18639 0.764705882352941 2.76764134780126 3.95782251696787e-05 0.00159476966124882 GO:0061630 ubiquitin protein ligase activity 131/5150 353/18639 0.371104815864023 1.34311119667758 5.76318619989084e-05 0.00221140155965921 GO:0044389 ubiquitin-like protein ligase binding 121/5150 322/18639 0.375776397515528 1.36001869384309 5.81098220056435e-05 0.00221140155965921 GO:0061659 ubiquitin-like protein ligase activity 137/5150 372/18639 0.368279569892473 1.33288600062637 5.99231907823507e-05 0.0022187776046438 GO:0019207 kinase regulator activity 109/5150 287/18639 0.379790940766551 1.37454822231995 8.04210467609855e-05 0.00289939037006711 GO:0019001 guanyl nucleotide binding 145/5150 400/18639 0.3625 1.31196844660194 8.94746411054198e-05 0.00303742196065329 GO:0032561 guanyl ribonucleotide binding 145/5150 400/18639 0.3625 1.31196844660194 8.94746411054198e-05 0.00303742196065329 GO:0022853 active monoatomic ion transmembrane transporter activity 52/5150 118/18639 0.440677966101695 1.59491196313971 9.09009491874341e-05 0.00303742196065329 GO:0005484 SNAP receptor activity 21/5150 36/18639 0.583333333333333 2.11121359223301 0.000106435017196997 0.00339106915255547 GO:0044390 ubiquitin-like protein conjugating enzyme binding 21/5150 36/18639 0.583333333333333 2.11121359223301 0.000106435017196997 0.00339106915255547 GO:0043023 ribosomal large subunit binding 12/5150 16/18639 0.75 2.71441747572816 0.000110658726953588 0.00344551036196399 GO:0003743 translation initiation factor activity 27/5150 51/18639 0.529411764705882 1.91605939463164 0.000115765759753179 0.00352442424137457 GO:0005525 GTP binding 137/5150 378/18639 0.362433862433862 1.31172907998151 0.000139090143801212 0.0041424673262535 GO:0019208 phosphatase regulator activity 51/5150 117/18639 0.435897435897436 1.57761015683346 0.000147814307063489 0.00430862980163788 GO:0140996 histone H3 kinase activity 130/5150 357/18639 0.364145658263305 1.31792445133393 0.000160961255202344 0.00459410249223356 GO:0106310 protein serine kinase activity 131/5150 361/18639 0.362880886426593 1.31334695963209 0.000180926495917024 0.00505855713074129 GO:0003924 GTPase activity 121/5150 331/18639 0.365558912386707 1.32303933358754 0.000222075280681846 0.00608486269068259 GO:0003684 damaged DNA binding 35/5150 74/18639 0.472972972972973 1.71179480451325 0.000238080532539695 0.0063839599431503 GO:0035173 histone kinase activity 130/5150 360/18639 0.361111111111111 1.30694174757282 0.00024231088835315 0.0063839599431503 GO:0141003 histone H2AX kinase activity 128/5150 354/18639 0.361581920903955 1.3086457133454 0.000253024459617261 0.00654044357878581 GO:1990948 ubiquitin ligase inhibitor activity 9/5150 11/18639 0.818181818181818 2.96118270079435 0.000290482722607224 0.00736965425873882 GO:0055105 ubiquitin-protein transferase inhibitor activity 11/5150 15/18639 0.733333333333333 2.65409708737864 0.000303847895768787 0.00756857485824069 GO:0031994 insulin-like growth factor I binding 10/5150 13/18639 0.769230769230769 2.78401792382375 0.000310754248797389 0.00760238072950755 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 29/5150 59/18639 0.491525423728814 1.7789402665789 0.000354046321643448 0.00850953439739516 GO:0035403 histone H3T6 kinase activity 93/5150 247/18639 0.376518218623482 1.36270351008215 0.000363359933577097 0.00858281222414867 GO:0000993 RNA polymerase II complex binding 20/5150 36/18639 0.555555555555556 2.01067961165049 0.000381337345242688 0.00870815752832892 GO:0061650 ubiquitin-like protein conjugating enzyme activity 22/5150 41/18639 0.536585365853659 1.94202225905754 0.000381379161824624 0.00870815752832892 GO:0180051 translation factor activity 38/5150 84/18639 0.452380952380952 1.63726768377254 0.000406570939671659 0.00913118339918316 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 14/5150 22/18639 0.636363636363636 2.30314210061783 0.000448371422698072 0.00990756208219932 GO:0019887 protein kinase regulator activity 95/5150 255/18639 0.372549019607843 1.34833809251856 0.000481321448780838 0.0104668315052341 GO:0140857 histone H3T45 kinase activity 92/5150 246/18639 0.373983739837398 1.35353066540374 0.000505439100348259 0.0105002654755622 GO:0001098 basal transcription machinery binding 29/5150 60/18639 0.483333333333333 1.74929126213592 0.000505852205392046 0.0105002654755622 GO:0001099 basal RNA polymerase II transcription machinery binding 29/5150 60/18639 0.483333333333333 1.74929126213592 0.000505852205392046 0.0105002654755622 GO:0045296 cadherin binding 120/5150 334/18639 0.359281437125749 1.30031974885181 0.000514038483532288 0.0105109361558095 GO:1901981 phosphatidylinositol phosphate binding 72/5150 185/18639 0.389189189189189 1.40856258199948 0.000542389668591519 0.010634595128424 GO:0051540 metal cluster binding 35/5150 77/18639 0.454545454545455 1.64510150044131 0.000606721122317047 0.010634595128424 GO:0000049 tRNA binding 36/5150 80/18639 0.45 1.62865048543689 0.000644434454148482 0.010634595128424 GO:0005543 phospholipid binding 170/5150 497/18639 0.3420523138833 1.23796370455744 0.000662307353002542 0.010634595128424 GO:0008135 translation factor activity, RNA binding 37/5150 83/18639 0.44578313253012 1.6133887004328 0.000680363078394034 0.010634595128424 GO:0019211 phosphatase activator activity 15/5150 25/18639 0.6 2.17153398058252 0.000691574688708319 0.010634595128424 GO:0004676 3-phosphoinositide-dependent protein kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0004711 ribosomal protein S6 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0035175 histone H3S10 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0035979 histone H2AXS139 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0044022 histone H3S28 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0044023 histone H4S1 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0044024 histone H2AS1 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0044025 histone H2BS14 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0072354 histone H3T3 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0072371 histone H2AS121 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0072518 Rho-dependent protein serine/threonine kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0140823 histone H2BS36 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0140855 histone H3S57 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0140995 histone H2A kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0140997 histone H4 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0140998 histone H2B kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:1990244 histone H2AT120 kinase activity 91/5150 245/18639 0.371428571428571 1.34428294036061 0.000698623037633694 0.010634595128424 GO:0008142 oxysterol binding 11/5150 16/18639 0.6875 2.48821601941748 0.000728864067162227 0.0109730084836511 GO:0031624 ubiquitin conjugating enzyme binding 17/5150 30/18639 0.566666666666667 2.0508932038835 0.000767628256613662 0.0114309859952252 GO:0051020 GTPase binding 113/5150 315/18639 0.358730158730159 1.29832454923717 0.000782755126888414 0.0115309088584637 GO:0004677 DNA-dependent protein kinase activity 91/5150 246/18639 0.369918699186992 1.3388183755624 0.000812040704039973 0.0118350613248379 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 90/5150 243/18639 0.37037037037037 1.34045307443366 0.000826743220248935 0.011922507492011 GO:0004602 glutathione peroxidase activity 14/5150 23/18639 0.608695652173913 2.20300548754749 0.000854982906372711 0.0122013185596939 GO:0047429 nucleoside triphosphate diphosphatase activity 8/5150 10/18639 0.8 2.8953786407767 0.000868290950589675 0.0122634907454418 GO:0035402 histone H3T11 kinase activity 91/5150 247/18639 0.368421052631579 1.33339805825243 0.000941698637698521 0.0131645625882344 GO:0051219 phosphoprotein binding 40/5150 93/18639 0.43010752688172 1.55665518321328 0.00100332910078314 0.0138844532128575 GO:0051536 iron-sulfur cluster binding 34/5150 76/18639 0.447368421052632 1.61912621359223 0.00102107539589283 0.0139887329237318 GO:0004674 protein serine/threonine kinase activity 149/5150 433/18639 0.344110854503464 1.24541402273594 0.00104004476698179 0.0141075379283669 GO:0072542 protein phosphatase activator activity 13/5150 21/18639 0.619047619047619 2.24047156726768 0.00105120800864439 0.0141191663906158 GO:0004679 AMP-activated protein kinase activity 91/5150 248/18639 0.366935483870968 1.32802145317883 0.00108957382840692 0.0144923897564804 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 21/5150 41/18639 0.51219512195122 1.85374852000947 0.00114953192843946 0.0150047612976876 GO:0004601 peroxidase activity 27/5150 57/18639 0.473684210526316 1.71436893203883 0.0011499999534724 0.0150047612976876 GO:0001222 transcription corepressor binding 24/5150 49/18639 0.489795918367347 1.77268080047553 0.00118788425853019 0.0153528437187393 GO:0035591 signaling adaptor activity 52/5150 129/18639 0.403100775193798 1.45891171822082 0.00121341012187096 0.0154595521271469 GO:0004112 cyclic-nucleotide phosphodiesterase activity 15/5150 26/18639 0.576923076923077 2.08801344286781 0.00121870921878238 0.0154595521271469 GO:0005096 GTPase activator activity 98/5150 271/18639 0.361623616236162 1.30879661806327 0.00124841098613027 0.0156910371651236 GO:0070273 phosphatidylinositol-4-phosphate binding 17/5150 31/18639 0.548387096774194 1.98473535859693 0.00126467752820873 0.0157509837604179 GO:0016776 phosphotransferase activity, phosphate group as acceptor 20/5150 39/18639 0.512820512820513 1.85601194921583 0.00146931071495785 0.0181347358512815 GO:0016209 antioxidant activity 37/5150 86/18639 0.430232558139535 1.55710769925491 0.00151254121390686 0.0184129637531616 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 14/5150 24/18639 0.583333333333333 2.11121359223301 0.00153217362617549 0.0184129637531616 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 14/5150 24/18639 0.583333333333333 2.11121359223301 0.00153217362617549 0.0184129637531616 GO:0019003 GDP binding 33/5150 75/18639 0.44 1.59245825242718 0.00169354072028411 0.0201465790043951 GO:0043175 RNA polymerase core enzyme binding 21/5150 42/18639 0.5 1.80961165048544 0.00170584172591959 0.0201465790043951 GO:0019888 protein phosphatase regulator activity 44/5150 107/18639 0.411214953271028 1.48827874058615 0.0017460688636781 0.0204454217370854 GO:0004715 non-membrane spanning protein tyrosine kinase activity 22/5150 45/18639 0.488888888888889 1.76939805825243 0.00193627378377868 0.0224804668116677 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 15/5150 27/18639 0.555555555555556 2.01067961165049 0.00204574184429856 0.0235518178713364 GO:0019903 protein phosphatase binding 56/5150 144/18639 0.388888888888889 1.40747572815534 0.00215212377512665 0.0245700797660293 GO:0070063 RNA polymerase binding 27/5150 59/18639 0.457627118644068 1.65625473095277 0.00217050266762056 0.0245751128482658 GO:0061631 ubiquitin conjugating enzyme activity 18/5150 35/18639 0.514285714285714 1.86131484049931 0.00240713189351731 0.027030907328842 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 63/5150 167/18639 0.377245508982036 1.3653357362944 0.00280923068752906 0.0312898052188196 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 11/5150 18/18639 0.611111111111111 2.21174757281553 0.00299244661187575 0.0330617085344336 GO:0071889 14-3-3 protein binding 17/5150 33/18639 0.515151515151515 1.86444836716681 0.00308588174119995 0.0338212638835515 GO:0051019 mitogen-activated protein kinase binding 15/5150 28/18639 0.535714285714286 1.93886962552011 0.00328952089809432 0.0351427062713323 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 15/5150 28/18639 0.535714285714286 1.93886962552011 0.00328952089809432 0.0351427062713323 GO:0003887 DNA-directed DNA polymerase activity 13/5150 23/18639 0.565217391304348 2.04564795272267 0.00330905774379699 0.0351427062713323 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 13/5150 23/18639 0.565217391304348 2.04564795272267 0.00330905774379699 0.0351427062713323 GO:0055106 ubiquitin-protein transferase regulator activity 18/5150 36/18639 0.5 1.80961165048544 0.00358370336504744 0.0377667200778076 GO:0034450 ubiquitin-ubiquitin ligase activity 10/5150 16/18639 0.625 2.2620145631068 0.00370210300623829 0.0384233418071701 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 10/5150 16/18639 0.625 2.2620145631068 0.00370210300623829 0.0384233418071701 GO:0008168 methyltransferase activity 74/5150 204/18639 0.362745098039216 1.31285551113649 0.0041853705768695 0.0430067400187285 GO:0010314 phosphatidylinositol-5-phosphate binding 12/5150 21/18639 0.571428571428571 2.06812760055479 0.00420649865876614 0.0430067400187285 GO:0015631 tubulin binding 130/5150 385/18639 0.337662337662338 1.22207540032783 0.0044124903512891 0.044778605787156 GO:0008175 tRNA methyltransferase activity 17/5150 34/18639 0.5 1.80961165048544 0.0046002288950716 0.046002288950716 GO:0052866 phosphatidylinositol phosphate phosphatase activity 17/5150 34/18639 0.5 1.80961165048544 0.0046002288950716 0.046002288950716 GO:0004540 RNA nuclease activity 47/5150 121/18639 0.388429752066116 1.40581400946803 0.00477907985287519 0.0474444883944856 GO:0045309 protein phosphorylated amino acid binding 26/5150 59/18639 0.440677966101695 1.59491196313971 0.00489037122638364 0.0479389484463487 GO:0051539 4 iron, 4 sulfur cluster binding 21/5150 45/18639 0.466666666666667 1.68897087378641 0.00489887064415243 0.0479389484463487 GO:0032266 phosphatidylinositol-3-phosphate binding 22/5150 48/18639 0.458333333333333 1.65881067961165 0.00526797022494491 0.0511852426111669 GO:0005520 insulin-like growth factor binding 11/5150 19/18639 0.578947368421053 2.09533980582524 0.00534309797776671 0.0515496072502845 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 8/5150 12/18639 0.666666666666667 2.41281553398058 0.00547673651897106 0.0524694337831493 GO:0031267 small GTPase binding 98/5150 283/18639 0.346289752650177 1.25329994167896 0.00556985720951508 0.0529910026183032 GO:0050661 NADP binding 24/5150 54/18639 0.444444444444444 1.60854368932039 0.00589966585812883 0.0553598782577842 GO:0051287 NAD binding 24/5150 54/18639 0.444444444444444 1.60854368932039 0.00589966585812883 0.0553598782577842 GO:0016504 peptidase activator activity 25/5150 57/18639 0.43859649122807 1.5873786407767 0.00616425156462216 0.057449147234914 GO:0050815 phosphoserine residue binding 7/5150 10/18639 0.7 2.53345631067961 0.00644946379605476 0.0593004389301679 GO:0070513 death domain binding 7/5150 10/18639 0.7 2.53345631067961 0.00644946379605476 0.0593004389301679 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 10/5150 17/18639 0.588235294117647 2.12895488292404 0.00677726970606129 0.0618990633153597 GO:0016741 transferase activity, transferring one-carbon groups 76/5150 215/18639 0.353488372093023 1.27935335290133 0.00775688671825863 0.070377051682214 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 26/5150 61/18639 0.426229508196721 1.54261976762693 0.00826674228167114 0.0745094534597991 GO:0019205 nucleobase-containing compound kinase activity 20/5150 44/18639 0.454545454545455 1.64510150044131 0.00852771492062454 0.0756990858356308 GO:0043014 alpha-tubulin binding 20/5150 44/18639 0.454545454545455 1.64510150044131 0.00852771492062454 0.0756990858356308 GO:0004129 cytochrome-c oxidase activity 9/5150 15/18639 0.6 2.17153398058252 0.00857569041816722 0.0756990858356308 GO:0008173 RNA methyltransferase activity 28/5150 67/18639 0.417910447761194 1.51251123025648 0.00861974991996964 0.0756990858356308 GO:0000149 SNARE binding 41/5150 106/18639 0.386792452830189 1.3998882579227 0.00870600178792972 0.0759695697418071 GO:0051537 2 iron, 2 sulfur cluster binding 14/5150 28/18639 0.5 1.80961165048544 0.00981645490469541 0.0851173621483083 GO:0015399 primary active transmembrane transporter activity 60/5150 166/18639 0.36144578313253 1.30815300035092 0.0099861717532474 0.0860443729682323 GO:0008170 N-methyltransferase activity 38/5150 98/18639 0.387755102040816 1.40337230037646 0.0107514361793106 0.0920591722853466 GO:0031492 nucleosomal DNA binding 19/5150 42/18639 0.452380952380952 1.63726768377254 0.010857633577986 0.092354763165937 GO:0052689 carboxylic ester hydrolase activity 36/5150 92/18639 0.391304347826087 1.41621781342339 0.0109207822137823 0.092354763165937 GO:0005164 tumor necrosis factor receptor binding 15/5150 31/18639 0.483870967741935 1.75123708111494 0.0110353706675839 0.0927512749361347 GO:0016779 nucleotidyltransferase activity 50/5150 136/18639 0.367647058823529 1.33059680182753 0.0124047327449562 0.103624901588963 GO:0043548 phosphatidylinositol 3-kinase binding 13/5150 26/18639 0.5 1.80961165048544 0.012683926625654 0.105315027134218 GO:0034056 estrogen response element binding 7/5150 11/18639 0.636363636363636 2.30314210061783 0.0135200778783672 0.110913213732713 GO:0048407 platelet-derived growth factor binding 7/5150 11/18639 0.636363636363636 2.30314210061783 0.0135200778783672 0.110913213732713 GO:0015036 disulfide oxidoreductase activity 18/5150 40/18639 0.45 1.62865048543689 0.0138311992276658 0.112790136558941 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 11/5150 21/18639 0.523809523809524 1.89578363384189 0.0141383884342808 0.113938777382145 GO:0009931 calcium-dependent protein serine/threonine kinase activity 11/5150 21/18639 0.523809523809524 1.89578363384189 0.0141383884342808 0.113938777382145 GO:0016922 nuclear receptor binding 50/5150 137/18639 0.364963503649635 1.32088441641273 0.0143972515820491 0.115346401563785 GO:0016675 oxidoreductase activity, acting on a heme group of donors 9/5150 16/18639 0.5625 2.03581310679612 0.0148417313763615 0.117532786044019 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 9/5150 16/18639 0.5625 2.03581310679612 0.0148417313763615 0.117532786044019 GO:0030291 protein serine/threonine kinase inhibitor activity 20/5150 46/18639 0.434782608695652 1.57357534824821 0.0150690924743825 0.118647452240828 GO:0016791 phosphatase activity 92/5150 273/18639 0.336996336996337 1.21966499519898 0.0154668940817563 0.121083685097178 GO:0030552 cAMP binding 12/5150 24/18639 0.5 1.80961165048544 0.0164262088341094 0.12786310285642 GO:0140566 histone reader activity 16/5150 35/18639 0.457142857142857 1.65450208044383 0.0166828378169902 0.129127049769924 GO:0050145 nucleoside monophosphate kinase activity 10/5150 19/18639 0.526315789473684 1.90485436893204 0.0183585214582671 0.140913106906647 GO:0042169 SH2 domain binding 18/5150 41/18639 0.439024390243902 1.58892730286526 0.0184112745520364 0.140913106906647 GO:0016248 channel inhibitor activity 19/5150 44/18639 0.431818181818182 1.56284642541924 0.0190486050895583 0.143830850964585 GO:0005161 platelet-derived growth factor receptor binding 8/5150 14/18639 0.571428571428571 2.06812760055479 0.0191667863294583 0.143830850964585 GO:0016530 metallochaperone activity 8/5150 14/18639 0.571428571428571 2.06812760055479 0.0191667863294583 0.143830850964585 GO:0016829 lyase activity 69/5150 200/18639 0.345 1.24863203883495 0.0192124421361453 0.143830850964585 GO:0005548 phospholipid transporter activity 27/5150 68/18639 0.397058823529412 1.43704454597373 0.0206182796382383 0.153516538610796 GO:0001221 transcription coregulator binding 42/5150 115/18639 0.365217391304348 1.32180329252849 0.0230823027770176 0.170933809754131 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 9/5150 17/18639 0.529411764705882 1.91605939463164 0.0239142507554493 0.176142599650352 GO:0141110 transporter inhibitor activity 19/5150 45/18639 0.422222222222222 1.52811650485437 0.0246154697129184 0.178682291687815 GO:0004126 cytidine deaminase activity 7/5150 12/18639 0.583333333333333 2.11121359223301 0.0247807557815218 0.178682291687815 GO:0035259 nuclear glucocorticoid receptor binding 7/5150 12/18639 0.583333333333333 2.11121359223301 0.0247807557815218 0.178682291687815 GO:0097371 MDM2/MDM4 family protein binding 7/5150 12/18639 0.583333333333333 2.11121359223301 0.0247807557815218 0.178682291687815 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 22/5150 54/18639 0.407407407407407 1.47449838187702 0.0254559629769325 0.182589891509935 GO:0003779 actin binding 141/5150 443/18639 0.318284424379232 1.15194240504942 0.0270079966933538 0.192713309739035 GO:0016004 phospholipase activator activity 10/5150 20/18639 0.5 1.80961165048544 0.0277810729360945 0.196185927435306 GO:0016408 C-acyltransferase activity 10/5150 20/18639 0.5 1.80961165048544 0.0277810729360945 0.196185927435306 GO:0140767 enzyme-substrate adaptor activity 49/5150 139/18639 0.352517985611511 1.27584130753649 0.0294064846363843 0.206599404881264 GO:0017022 myosin binding 29/5150 76/18639 0.381578947368421 1.38101941747573 0.029634713540031 0.207140599744094 GO:0004521 RNA endonuclease activity 28/5150 73/18639 0.383561643835616 1.38819523872855 0.0300525102639348 0.208994614525841 GO:0008200 ion channel inhibitor activity 18/5150 43/18639 0.418604651162791 1.51502370738316 0.0309676338195233 0.213139937517594 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 8/5150 15/18639 0.533333333333333 1.93025242718447 0.0312708959423623 0.213139937517594 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 8/5150 15/18639 0.533333333333333 1.93025242718447 0.0312708959423623 0.213139937517594 GO:0045504 dynein heavy chain binding 8/5150 15/18639 0.533333333333333 1.93025242718447 0.0312708959423623 0.213139937517594 GO:0004862 cAMP-dependent protein kinase inhibitor activity 6/5150 10/18639 0.6 2.17153398058252 0.032055698193294 0.213185954003945 GO:0008641 ubiquitin-like modifier activating enzyme activity 6/5150 10/18639 0.6 2.17153398058252 0.032055698193294 0.213185954003945 GO:0016427 tRNA (cytidine) methyltransferase activity 6/5150 10/18639 0.6 2.17153398058252 0.032055698193294 0.213185954003945 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 6/5150 10/18639 0.6 2.17153398058252 0.032055698193294 0.213185954003945 GO:1905394 retromer complex binding 6/5150 10/18639 0.6 2.17153398058252 0.032055698193294 0.213185954003945 GO:0120014 phospholipid transfer activity 12/5150 26/18639 0.461538461538462 1.67041075429425 0.0333075310321804 0.220441147411049 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 13/5150 29/18639 0.448275862068966 1.62241044526281 0.0351957599078259 0.231818226315969 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 9/5150 18/18639 0.5 1.80961165048544 0.0363202029371055 0.237132161801822 GO:0017124 SH3 domain binding 41/5150 115/18639 0.356521739130435 1.29033178556353 0.0363487255316661 0.237132161801822 GO:0042578 phosphoric ester hydrolase activity 116/5150 363/18639 0.319559228650138 1.15655620637086 0.0371619129264946 0.241288249807097 GO:0000175 3'-5'-RNA exonuclease activity 15/5150 35/18639 0.428571428571429 1.55109570041609 0.0376920519407377 0.242206883045438 GO:0034061 DNA polymerase activity 15/5150 35/18639 0.428571428571429 1.55109570041609 0.0376920519407377 0.242206883045438 GO:0003713 transcription coactivator activity 84/5150 256/18639 0.328125 1.18755764563107 0.0378337758917692 0.242206883045438 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 16/5150 38/18639 0.421052631578947 1.52388349514563 0.0384431718405609 0.244200348599694 GO:0001786 phosphatidylserine binding 23/5150 59/18639 0.389830508474576 1.41088365970051 0.0385016608011197 0.244200348599694 GO:0019212 phosphatase inhibitor activity 22/5150 56/18639 0.392857142857143 1.42183772538141 0.0388516795503265 0.245284797161048 GO:0016251 RNA polymerase II general transcription initiation factor activity 21/5150 53/18639 0.39622641509434 1.43403187396959 0.0391175218545314 0.245735924373197 GO:0015605 organophosphate ester transmembrane transporter activity 20/5150 50/18639 0.4 1.44768932038835 0.0392818740421388 0.245735924373197 GO:0051010 microtubule plus-end binding 10/5150 21/18639 0.476190476190476 1.72343966712899 0.0401835133922888 0.250155071550738 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 7/5150 13/18639 0.538461538461538 1.94881254667662 0.0410838621159971 0.250155071550738 GO:0035325 Toll-like receptor binding 7/5150 13/18639 0.538461538461538 1.94881254667662 0.0410838621159971 0.250155071550738 GO:0043560 insulin receptor substrate binding 7/5150 13/18639 0.538461538461538 1.94881254667662 0.0410838621159971 0.250155071550738 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 7/5150 13/18639 0.538461538461538 1.94881254667662 0.0410838621159971 0.250155071550738 GO:0140333 glycerophospholipid flippase activity 7/5150 13/18639 0.538461538461538 1.94881254667662 0.0410838621159971 0.250155071550738 GO:0004622 lysophospholipase activity 11/5150 24/18639 0.458333333333333 1.65881067961165 0.0430962462427229 0.261247156427125 GO:0004721 phosphoprotein phosphatase activity 59/5150 175/18639 0.337142857142857 1.22019528432732 0.044380970778866 0.267849911749103 GO:0004364 glutathione transferase activity 12/5150 27/18639 0.444444444444444 1.60854368932039 0.0452520029336661 0.270117731753911 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 12/5150 27/18639 0.444444444444444 1.60854368932039 0.0452520029336661 0.270117731753911 GO:0003712 transcription coregulator activity 154/5150 495/18639 0.311111111111111 1.12598058252427 0.0453482323382479 0.270117731753911 GO:0001965 G-protein alpha-subunit binding 13/5150 30/18639 0.433333333333333 1.56833009708738 0.046804428769138 0.274575978556544 GO:0015215 nucleotide transmembrane transporter activity 13/5150 30/18639 0.433333333333333 1.56833009708738 0.046804428769138 0.274575978556544 GO:0000062 fatty-acyl-CoA binding 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0004708 MAP kinase kinase activity 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0015385 sodium:proton antiporter activity 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0140327 flippase activity 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0140328 floppase activity 8/5150 16/18639 0.5 1.80961165048544 0.0477000605083632 0.274575978556544 GO:0008017 microtubule binding 89/5150 276/18639 0.322463768115942 1.16706838328409 0.0500394560051503 0.286794343127777 GO:0008276 protein methyltransferase activity 34/5150 95/18639 0.357894736842105 1.29530097087379 0.0502413447815083 0.286794343127777 GO:0005346 purine ribonucleotide transmembrane transporter activity 9/5150 19/18639 0.473684210526316 1.71436893203883 0.05248571626806 0.298362785424242 GO:0002162 dystroglycan binding 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0008432 JUN kinase binding 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0010854 adenylate cyclase regulator activity 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0042608 T cell receptor binding 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0070990 snRNP binding 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0140537 transcription regulator activator activity 6/5150 11/18639 0.545454545454545 1.97412180052957 0.0542984425712061 0.299955106139324 GO:0035401 histone H3Y41 kinase activity 40/5150 115/18639 0.347826086956522 1.25886027859856 0.0553878162332919 0.30352523295844 GO:0140801 histone H2AXY142 kinase activity 40/5150 115/18639 0.347826086956522 1.25886027859856 0.0553878162332919 0.30352523295844 GO:0019905 syntaxin binding 23/5150 61/18639 0.377049180327869 1.36462517905459 0.055780156397094 0.304457427346689 GO:0008408 3'-5' exonuclease activity 22/5150 58/18639 0.379310344827586 1.3728088382993 0.0568199671539991 0.308902202384837 GO:0017025 TBP-class protein binding 11/5150 25/18639 0.44 1.59245825242718 0.058266269132494 0.315456398440744 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 110/5150 349/18639 0.315186246418338 1.1407294071828 0.0584860767912036 0.315456398440744 GO:0046625 sphingolipid binding 12/5150 28/18639 0.428571428571429 1.55109570041609 0.0598439832045151 0.320258816367913 GO:0051959 dynein light intermediate chain binding 12/5150 28/18639 0.428571428571429 1.55109570041609 0.0598439832045151 0.320258816367913 GO:0004532 RNA exonuclease activity 16/5150 40/18639 0.4 1.44768932038835 0.0612594096398466 0.324925555964151 GO:0030331 nuclear estrogen receptor binding 16/5150 40/18639 0.4 1.44768932038835 0.0612594096398466 0.324925555964151 GO:0030551 cyclic nucleotide binding 15/5150 37/18639 0.405405405405405 1.46725268958279 0.0614275321129308 0.324925555964151 GO:0005347 ATP transmembrane transporter activity 7/5150 14/18639 0.5 1.80961165048544 0.063000937902536 0.327963900334681 GO:0034236 protein kinase A catalytic subunit binding 7/5150 14/18639 0.5 1.80961165048544 0.063000937902536 0.327963900334681 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 7/5150 14/18639 0.5 1.80961165048544 0.063000937902536 0.327963900334681 GO:0071933 Arp2/3 complex binding 7/5150 14/18639 0.5 1.80961165048544 0.063000937902536 0.327963900334681 GO:0032934 sterol binding 25/5150 68/18639 0.367647058823529 1.33059680182753 0.0631988829842012 0.327963900334681 GO:0004518 nuclease activity 68/5150 209/18639 0.325358851674641 1.17754633715799 0.066292767379059 0.342721099280418 GO:0008429 phosphatidylethanolamine binding 8/5150 17/18639 0.470588235294118 1.70316390633923 0.0688430025109532 0.350613061115263 GO:0032977 membrane insertase activity 8/5150 17/18639 0.470588235294118 1.70316390633923 0.0688430025109532 0.350613061115263 GO:0046965 nuclear retinoid X receptor binding 8/5150 17/18639 0.470588235294118 1.70316390633923 0.0688430025109532 0.350613061115263 GO:1901567 fatty acid derivative binding 8/5150 17/18639 0.470588235294118 1.70316390633923 0.0688430025109532 0.350613061115263 GO:0016798 hydrolase activity, acting on glycosyl bonds 44/5150 130/18639 0.338461538461538 1.22496788648245 0.069882995065747 0.352607065563717 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 44/5150 130/18639 0.338461538461538 1.22496788648245 0.069882995065747 0.352607065563717 GO:0072341 modified amino acid binding 32/5150 91/18639 0.351648351648352 1.27269390803371 0.0700066582725045 0.352607065563717 GO:0004864 protein phosphatase inhibitor activity 20/5150 53/18639 0.377358490566038 1.3657446418758 0.0706148837736059 0.353074418868029 GO:0140296 general transcription initiation factor binding 20/5150 53/18639 0.377358490566038 1.3657446418758 0.0706148837736059 0.353074418868029 GO:0019783 ubiquitin-like protein peptidase activity 43/5150 127/18639 0.338582677165354 1.22540631450195 0.0720823696864677 0.359101259892585 GO:0016505 peptidase activator activity involved in apoptotic process 9/5150 20/18639 0.45 1.62865048543689 0.072698606266941 0.360859023861265 GO:0001223 transcription coactivator binding 17/5150 44/18639 0.386363636363636 1.39833627537511 0.0744887865294469 0.367670791193996 GO:0000295 adenine nucleotide transmembrane transporter activity 10/5150 23/18639 0.434782608695652 1.57357534824821 0.0751443952805246 0.367670791193996 GO:0005158 insulin receptor binding 10/5150 23/18639 0.434782608695652 1.57357534824821 0.0751443952805246 0.367670791193996 GO:0043274 phospholipase binding 10/5150 23/18639 0.434782608695652 1.57357534824821 0.0751443952805246 0.367670791193996 GO:0016877 ligase activity, forming carbon-sulfur bonds 16/5150 41/18639 0.390243902439024 1.41237982476912 0.0755453263393752 0.367976158066998 GO:0008198 ferrous iron binding 11/5150 26/18639 0.423076923076923 1.53120985810306 0.0765693437393908 0.367976158066998 GO:0015216 purine nucleotide transmembrane transporter activity 11/5150 26/18639 0.423076923076923 1.53120985810306 0.0765693437393908 0.367976158066998 GO:0097602 cullin family protein binding 11/5150 26/18639 0.423076923076923 1.53120985810306 0.0765693437393908 0.367976158066998 GO:0043015 gamma-tubulin binding 14/5150 35/18639 0.4 1.44768932038835 0.0770463444742203 0.367976158066998 GO:0030515 snoRNA binding 13/5150 32/18639 0.40625 1.47030946601942 0.0773555719148142 0.367976158066998 GO:0051059 NF-kappaB binding 13/5150 32/18639 0.40625 1.47030946601942 0.0773555719148142 0.367976158066998 GO:0140142 nucleocytoplasmic carrier activity 13/5150 32/18639 0.40625 1.47030946601942 0.0773555719148142 0.367976158066998 GO:0016835 carbon-oxygen lyase activity 28/5150 79/18639 0.354430379746835 1.2827626889517 0.0786987291649575 0.373070100193743 GO:0019209 kinase activator activity 49/5150 148/18639 0.331081081081081 1.19825636315928 0.0818937623469552 0.382456624421322 GO:0015932 nucleobase-containing compound transmembrane transporter activity 21/5150 57/18639 0.368421052631579 1.33339805825243 0.081991889850306 0.382456624421322 GO:0004857 enzyme inhibitor activity 128/5150 416/18639 0.307692307692308 1.1136071695295 0.0829198673608476 0.382456624421322 GO:0043539 protein serine/threonine kinase activator activity 26/5150 73/18639 0.356164383561644 1.28903843596223 0.0834179075179316 0.382456624421322 GO:0005078 MAP-kinase scaffold activity 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0008603 cAMP-dependent protein kinase regulator activity 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0016423 tRNA (guanine) methyltransferase activity 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0016840 carbon-nitrogen lyase activity 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0034452 dynactin binding 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0043047 single-stranded telomeric DNA binding 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 6/5150 12/18639 0.5 1.80961165048544 0.0838161293608904 0.382456624421322 GO:0003925 G protein activity 20/5150 54/18639 0.37037037037037 1.34045307443366 0.0840287912049766 0.382456624421322 GO:0050660 flavin adenine dinucleotide binding 30/5150 86/18639 0.348837209302326 1.26251975615263 0.0848718647091395 0.385014750501725 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 24/5150 67/18639 0.358208955223881 1.2964381973627 0.0883862978094054 0.399634415837905 GO:0140303 intramembrane lipid transporter activity 17/5150 45/18639 0.377777777777778 1.36726213592233 0.0899913604608908 0.405041279238542 GO:0010181 FMN binding 7/5150 15/18639 0.466666666666667 1.68897087378641 0.0907647246176879 0.405041279238542 GO:0030553 cGMP binding 7/5150 15/18639 0.466666666666667 1.68897087378641 0.0907647246176879 0.405041279238542 GO:0051371 muscle alpha-actinin binding 7/5150 15/18639 0.466666666666667 1.68897087378641 0.0907647246176879 0.405041279238542 GO:0004722 protein serine/threonine phosphatase activity 35/5150 103/18639 0.339805825242718 1.22983316052408 0.0927625886073115 0.412062533996049 GO:0044325 transmembrane transporter binding 45/5150 136/18639 0.330882352941176 1.19753712164477 0.0929396518283059 0.412062533996049 GO:0016854 racemase and epimerase activity 8/5150 18/18639 0.444444444444444 1.60854368932039 0.0948612421700314 0.416538146708151 GO:0070064 proline-rich region binding 8/5150 18/18639 0.444444444444444 1.60854368932039 0.0948612421700314 0.416538146708151 GO:0098641 cadherin binding involved in cell-cell adhesion 8/5150 18/18639 0.444444444444444 1.60854368932039 0.0948612421700314 0.416538146708151 GO:0031491 nucleosome binding 26/5150 74/18639 0.351351351351351 1.27161899763842 0.0959988207856713 0.420186531873385 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 13/5150 33/18639 0.393939393939394 1.4257546337158 0.0965184026427128 0.421115323632218 GO:0051721 protein phosphatase 2A binding 12/5150 30/18639 0.4 1.44768932038835 0.0975349292555774 0.422356051953807 GO:0048027 mRNA 5'-UTR binding 10/5150 24/18639 0.416666666666667 1.50800970873786 0.098035930307526 0.422356051953807 GO:0060229 lipase activator activity 10/5150 24/18639 0.416666666666667 1.50800970873786 0.098035930307526 0.422356051953807 GO:0070300 phosphatidic acid binding 10/5150 24/18639 0.416666666666667 1.50800970873786 0.098035930307526 0.422356051953807 GO:0030159 signaling receptor complex adaptor activity 19/5150 52/18639 0.365384615384615 1.32240851381628 0.101785276244312 0.437134258478709 GO:0030145 manganese ion binding 24/5150 68/18639 0.352941176470588 1.27737292975443 0.102124887714062 0.437222175525829 GO:0120013 lipid transfer activity 23/5150 65/18639 0.353846153846154 1.28064824495892 0.105336650976639 0.448171465335391 GO:0160215 deacylase activity 23/5150 65/18639 0.353846153846154 1.28064824495892 0.105336650976639 0.448171465335391 GO:0003697 single-stranded DNA binding 40/5150 121/18639 0.330578512396694 1.1964374548664 0.109217101858611 0.46324281593281 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0015924 mannosyl-oligosaccharide mannosidase activity 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0016175 superoxide-generating NAD(P)H oxidase activity 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0031996 thioesterase binding 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0035256 G protein-coupled glutamate receptor binding 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0051864 histone H3K36 demethylase activity 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0097177 mitochondrial ribosome binding 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0098505 G-rich strand telomeric DNA binding 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0099122 RNA polymerase II C-terminal domain binding 5/5150 10/18639 0.5 1.80961165048544 0.11259215786601 0.463515641440009 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 15/5150 40/18639 0.375 1.35720873786408 0.113003083387564 0.463515641440009 GO:0050997 quaternary ammonium group binding 15/5150 40/18639 0.375 1.35720873786408 0.113003083387564 0.463515641440009 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 28/5150 82/18639 0.341463414634146 1.23583234667298 0.116598337640698 0.47683499273957 GO:0015035 protein-disulfide reductase activity 13/5150 34/18639 0.382352941176471 1.38382067390063 0.118317406326737 0.479415890770987 GO:0051018 protein kinase A binding 19/5150 53/18639 0.358490566037736 1.29745740978201 0.119204024977942 0.479415890770987 GO:1901505 carbohydrate derivative transmembrane transporter activity 19/5150 53/18639 0.358490566037736 1.29745740978201 0.119204024977942 0.479415890770987 GO:0005338 nucleotide-sugar transmembrane transporter activity 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0019855 calcium channel inhibitor activity 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0031432 titin binding 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0046975 histone H3K36 methyltransferase activity 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0070123 transforming growth factor beta receptor activity, type III 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0140852 histone ubiquitin ligase activity 6/5150 13/18639 0.461538461538462 1.67041075429425 0.12044378699937 0.479415890770987 GO:0047499 calcium-independent phospholipase A2 activity 12/5150 31/18639 0.387096774193548 1.40098966489195 0.120728819208752 0.479415890770987 GO:0046875 ephrin receptor binding 11/5150 28/18639 0.392857142857143 1.42183772538141 0.122853918821381 0.480953449311319 GO:0046966 nuclear thyroid hormone receptor binding 11/5150 28/18639 0.392857142857143 1.42183772538141 0.122853918821381 0.480953449311319 GO:0015923 mannosidase activity 7/5150 16/18639 0.4375 1.58341019417476 0.124259463369385 0.480953449311319 GO:0003707 nuclear steroid receptor activity 10/5150 25/18639 0.4 1.44768932038835 0.124549037757547 0.480953449311319 GO:0047617 fatty acyl-CoA hydrolase activity 10/5150 25/18639 0.4 1.44768932038835 0.124549037757547 0.480953449311319 GO:0008093 cytoskeletal anchor activity 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0031683 G-protein beta/gamma-subunit complex binding 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0034062 5'-3' RNA polymerase activity 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0061133 endopeptidase activator activity 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0097747 RNA polymerase activity 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0140517 protein-RNA adaptor activity 9/5150 22/18639 0.409090909090909 1.48059135039718 0.125600518897797 0.480953449311319 GO:0042800 histone H3K4 methyltransferase activity 8/5150 19/18639 0.421052631578947 1.52388349514563 0.125679806462374 0.480953449311319 GO:0120227 acyl-CoA binding 8/5150 19/18639 0.421052631578947 1.52388349514563 0.125679806462374 0.480953449311319 GO:0001784 phosphotyrosine residue binding 17/5150 47/18639 0.361702127659574 1.30908076843627 0.126737364115676 0.483649551082105 GO:0140789 histone phosphatase activity 44/5150 136/18639 0.323529411764706 1.17092518560822 0.127895601756322 0.486713817794893 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 21/5150 60/18639 0.35 1.26672815533981 0.129355427160201 0.489549544777555 GO:0098531 ligand-modulated transcription factor activity 21/5150 60/18639 0.35 1.26672815533981 0.129355427160201 0.489549544777555 GO:0001046 core promoter sequence-specific DNA binding 16/5150 44/18639 0.363636363636364 1.31608120035305 0.130638058491893 0.493041708357833 GO:0046982 protein heterodimerization activity 112/5150 369/18639 0.303523035230352 1.09851764148709 0.131284067502222 0.494118605708913 GO:0004713 protein tyrosine kinase activity 45/5150 140/18639 0.321428571428571 1.16332177531207 0.135399954217452 0.508213526788792 GO:0048306 calcium-dependent protein binding 27/5150 80/18639 0.3375 1.22148786407767 0.136004839834956 0.509089154573471 GO:0140463 chromatin-protein adaptor activity 19/5150 54/18639 0.351851851851852 1.27343042071197 0.138299151883267 0.515301073331727 GO:0015085 calcium ion transmembrane transporter activity 47/5150 147/18639 0.319727891156463 1.15716663364375 0.138416638675968 0.515301073331727 GO:0005154 epidermal growth factor receptor binding 13/5150 35/18639 0.371428571428571 1.34428294036061 0.14270485196686 0.529825602153384 GO:0004527 exonuclease activity 28/5150 84/18639 0.333333333333333 1.20640776699029 0.147287126625388 0.538534893356093 GO:0016836 hydro-lyase activity 21/5150 61/18639 0.344262295081967 1.24596212000637 0.148130585512337 0.538534893356093 GO:0005262 calcium channel activity 42/5150 131/18639 0.320610687022901 1.16036166901356 0.149331091928364 0.538534893356093 GO:0033192 calmodulin-dependent protein phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0140791 histone H2AXS140 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:1990439 MAP kinase serine/threonine phosphatase activity 27/5150 81/18639 0.333333333333333 1.20640776699029 0.152565554771318 0.538534893356093 GO:0016289 acyl-CoA hydrolase activity 10/5150 26/18639 0.384615384615385 1.39200896191187 0.154536346518896 0.538534893356093 GO:0030507 spectrin binding 10/5150 26/18639 0.384615384615385 1.39200896191187 0.154536346518896 0.538534893356093 GO:0034237 protein kinase A regulatory subunit binding 10/5150 26/18639 0.384615384615385 1.39200896191187 0.154536346518896 0.538534893356093 GO:0052742 phosphatidylinositol kinase activity 10/5150 26/18639 0.384615384615385 1.39200896191187 0.154536346518896 0.538534893356093 GO:0070412 R-SMAD binding 10/5150 26/18639 0.384615384615385 1.39200896191187 0.154536346518896 0.538534893356093 GO:1990841 promoter-specific chromatin binding 23/5150 68/18639 0.338235294117647 1.22414905768133 0.156567135535971 0.538534893356093 GO:0005496 steroid binding 35/5150 108/18639 0.324074074074074 1.17289644012945 0.15726108970962 0.538534893356093 GO:0140102 catalytic activity, acting on a rRNA 9/5150 23/18639 0.391304347826087 1.41621781342339 0.158036598366044 0.538534893356093 GO:0001614 purinergic nucleotide receptor activity 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0016502 nucleotide receptor activity 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0030742 GTP-dependent protein binding 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0052745 inositol phosphate phosphatase activity 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0061608 nuclear import signal receptor activity 8/5150 20/18639 0.4 1.44768932038835 0.161000606592663 0.538534893356093 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0008526 phosphatidylinositol transfer activity 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0032050 clathrin heavy chain binding 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0050786 RAGE receptor binding 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0180030 inositol phosphate kinase activity 5/5150 11/18639 0.454545454545455 1.64510150044131 0.161170253945014 0.538534893356093 GO:0005516 calmodulin binding 64/5150 207/18639 0.309178743961353 1.11898691430984 0.162050998494909 0.538534893356093 GO:0004549 tRNA-specific ribonuclease activity 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0004550 nucleoside diphosphate kinase activity 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0005092 GDP-dissociation inhibitor activity 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0031489 myosin V binding 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0032183 SUMO binding 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0048038 quinone binding 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0070403 NAD+ binding 7/5150 17/18639 0.411764705882353 1.49026841804683 0.163050985970287 0.538534893356093 GO:0004705 JUN kinase activity 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0019763 immunoglobulin receptor activity 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0019992 diacylglycerol binding 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0032036 myosin heavy chain binding 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0046030 inositol trisphosphate phosphatase activity 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:0098847 sequence-specific single stranded DNA binding 6/5150 14/18639 0.428571428571429 1.55109570041609 0.163525923821996 0.538534893356093 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 39/5150 122/18639 0.319672131147541 1.1569648257202 0.16495660159255 0.541943751035476 GO:0030295 protein kinase activator activity 44/5150 139/18639 0.316546762589928 1.14565341901236 0.165795441262558 0.543396541937093 GO:0045505 dynein intermediate chain binding 13/5150 36/18639 0.361111111111111 1.30694174757282 0.169568875050358 0.553402401729757 GO:0043178 alcohol binding 30/5150 92/18639 0.326086956521739 1.18018151118615 0.169656210749269 0.553402401729757 GO:0033549 MAP kinase phosphatase activity 27/5150 82/18639 0.329268292682927 1.19169547714895 0.170222188635441 0.553929687483502 GO:0016763 pentosyltransferase activity 17/5150 49/18639 0.346938775510204 1.25564890033683 0.170992175507309 0.555116778305717 GO:0004879 nuclear receptor activity 20/5150 59/18639 0.338983050847458 1.22685535626131 0.174686637949589 0.56443559903523 GO:0031593 polyubiquitin modification-dependent protein binding 20/5150 59/18639 0.338983050847458 1.22685535626131 0.174686637949589 0.56443559903523 GO:0019239 deaminase activity 12/5150 33/18639 0.363636363636364 1.31608120035305 0.175458118980773 0.565594407067435 GO:0046332 SMAD binding 26/5150 79/18639 0.329113924050633 1.19113678259801 0.176493024503215 0.56634488271346 GO:0019842 vitamin binding 47/5150 150/18639 0.313333333333333 1.13402330097087 0.176517711619451 0.56634488271346 GO:0001968 fibronectin binding 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0031210 phosphatidylcholine binding 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0043995 histone H4K5 acetyltransferase activity 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0043996 histone H4K8 acetyltransferase activity 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0043997 histone H4K12 acetyltransferase activity 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0070566 adenylyltransferase activity 11/5150 30/18639 0.366666666666667 1.32704854368932 0.18152307833879 0.574333989201253 GO:0042393 histone binding 75/5150 247/18639 0.303643724696356 1.09895444361464 0.184630747883511 0.582820563595416 GO:0008320 protein transmembrane transporter activity 10/5150 27/18639 0.37037037037037 1.34045307443366 0.18773418826923 0.589898710845976 GO:0015252 proton channel activity 10/5150 27/18639 0.37037037037037 1.34045307443366 0.18773418826923 0.589898710845976 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 27/5150 83/18639 0.325301204819277 1.17733770031583 0.188938976279218 0.589921355117857 GO:0030165 PDZ domain binding 27/5150 83/18639 0.325301204819277 1.17733770031583 0.188938976279218 0.589921355117857 GO:0004519 endonuclease activity 40/5150 127/18639 0.31496062992126 1.13991285069949 0.189033193355284 0.589921355117857 GO:0005507 copper ion binding 21/5150 63/18639 0.333333333333333 1.20640776699029 0.189961944282074 0.590149947887712 GO:0032451 demethylase activity 14/5150 40/18639 0.35 1.26672815533981 0.191260275081857 0.590149947887712 GO:0061791 GTPase motor activity 14/5150 40/18639 0.35 1.26672815533981 0.191260275081857 0.590149947887712 GO:0071949 FAD binding 14/5150 40/18639 0.35 1.26672815533981 0.191260275081857 0.590149947887712 GO:1990606 membrane scission GTPase motor activity 14/5150 40/18639 0.35 1.26672815533981 0.191260275081857 0.590149947887712 GO:0001091 RNA polymerase II general transcription initiation factor binding 9/5150 24/18639 0.375 1.35720873786408 0.194036999201155 0.59603293476588 GO:0043998 histone H2A acetyltransferase activity 9/5150 24/18639 0.375 1.35720873786408 0.194036999201155 0.59603293476588 GO:0032813 tumor necrosis factor receptor superfamily binding 17/5150 50/18639 0.34 1.2305359223301 0.19575486852106 0.599964585847544 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 20/5150 60/18639 0.333333333333333 1.20640776699029 0.197352243344283 0.603510208441222 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 8/5150 21/18639 0.380952380952381 1.37875173370319 0.200333333158652 0.607205014219808 GO:0019200 carbohydrate kinase activity 8/5150 21/18639 0.380952380952381 1.37875173370319 0.200333333158652 0.607205014219808 GO:0070182 DNA polymerase binding 8/5150 21/18639 0.380952380952381 1.37875173370319 0.200333333158652 0.607205014219808 GO:0140312 cargo adaptor activity 8/5150 21/18639 0.380952380952381 1.37875173370319 0.200333333158652 0.607205014219808 GO:0008308 voltage-gated monoatomic anion channel activity 7/5150 18/18639 0.388888888888889 1.40747572815534 0.206444459297722 0.612602859720757 GO:0008525 phosphatidylcholine transporter activity 7/5150 18/18639 0.388888888888889 1.40747572815534 0.206444459297722 0.612602859720757 GO:0017075 syntaxin-1 binding 7/5150 18/18639 0.388888888888889 1.40747572815534 0.206444459297722 0.612602859720757 GO:0070628 proteasome binding 7/5150 18/18639 0.388888888888889 1.40747572815534 0.206444459297722 0.612602859720757 GO:1901611 phosphatidylglycerol binding 7/5150 18/18639 0.388888888888889 1.40747572815534 0.206444459297722 0.612602859720757 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 12/5150 34/18639 0.352941176470588 1.27737292975443 0.20662578042843 0.612602859720757 GO:0030332 cyclin binding 12/5150 34/18639 0.352941176470588 1.27737292975443 0.20662578042843 0.612602859720757 GO:0017018 myosin phosphatase activity 27/5150 84/18639 0.321428571428571 1.16332177531207 0.208668799799453 0.612602859720757 GO:0051117 ATPase binding 27/5150 84/18639 0.321428571428571 1.16332177531207 0.208668799799453 0.612602859720757 GO:0140030 modification-dependent protein binding 53/5150 173/18639 0.30635838150289 1.10877939278298 0.209775649919226 0.612602859720757 GO:0030020 extracellular matrix structural constituent conferring tensile strength 15/5150 44/18639 0.340909090909091 1.23382612533098 0.211846839327831 0.612602859720757 GO:0004559 alpha-mannosidase activity 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0008252 nucleotidase activity 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0017081 chloride channel regulator activity 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0031386 protein tag activity 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0050700 CARD domain binding 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0141047 molecular tag activity 6/5150 15/18639 0.4 1.44768932038835 0.212033389958202 0.612602859720757 GO:0015485 cholesterol binding 18/5150 54/18639 0.333333333333333 1.20640776699029 0.213388543168605 0.612602859720757 GO:0003995 acyl-CoA dehydrogenase activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0004032 aldose reductase (NADPH) activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0004300 enoyl-CoA hydratase activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0005025 transforming growth factor beta receptor activity, type I 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0005026 transforming growth factor beta receptor activity, type II 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0005049 nuclear export signal receptor activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0005095 GTPase inhibitor activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0016361 activin receptor activity, type I 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0016362 activin receptor activity, type II 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0016801 hydrolase activity, acting on ether bonds 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0016803 ether hydrolase activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0017002 activin receptor activity 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0035497 cAMP response element binding 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 5/5150 12/18639 0.416666666666667 1.50800970873786 0.21642320007653 0.612602859720757 GO:0030527 structural constituent of chromatin 31/5150 98/18639 0.316326530612245 1.14485635030711 0.217184536323103 0.613490339716805 GO:0140828 metal cation:monoatomic cation antiporter activity 14/5150 41/18639 0.341463414634146 1.23583234667298 0.220632766245109 0.621948332830863 GO:0016830 carbon-carbon lyase activity 17/5150 51/18639 0.333333333333333 1.20640776699029 0.22211508132821 0.624841193880181 GO:0036408 histone H3K14 acetyltransferase activity 10/5150 28/18639 0.357142857142857 1.29257975034674 0.223778782406924 0.626946690996904 GO:0141052 histone H3 demethylase activity 10/5150 28/18639 0.357142857142857 1.29257975034674 0.223778782406924 0.626946690996904 GO:0140223 general transcription initiation factor activity 22/5150 68/18639 0.323529411764706 1.17092518560822 0.227932344166796 0.637034475268845 GO:0051015 actin filament binding 63/5150 209/18639 0.301435406698565 1.09096204766108 0.228309436027009 0.637034475268845 GO:0043531 ADP binding 13/5150 38/18639 0.342105263157895 1.23815533980583 0.229985930940622 0.64040797843222 GO:0016879 ligase activity, forming carbon-nitrogen bonds 16/5150 48/18639 0.333333333333333 1.20640776699029 0.231378592126192 0.641677472090857 GO:0038187 pattern recognition receptor activity 16/5150 48/18639 0.333333333333333 1.20640776699029 0.231378592126192 0.641677472090857 GO:0017056 structural constituent of nuclear pore 9/5150 25/18639 0.36 1.30292038834951 0.233123977513185 0.643392120562677 GO:0042974 nuclear retinoic acid receptor binding 9/5150 25/18639 0.36 1.30292038834951 0.233123977513185 0.643392120562677 GO:0003725 double-stranded RNA binding 24/5150 75/18639 0.32 1.15815145631068 0.233405754685876 0.643392120562677 GO:0140313 molecular sequestering activity 18/5150 55/18639 0.327272727272727 1.18447308031774 0.239831251917028 0.644026661271333 GO:0004623 phospholipase A2 activity 12/5150 35/18639 0.342857142857143 1.24087656033287 0.239975830060553 0.644026661271333 GO:0010485 histone H4 acetyltransferase activity 12/5150 35/18639 0.342857142857143 1.24087656033287 0.239975830060553 0.644026661271333 GO:0008649 rRNA methyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0030021 extracellular matrix structural constituent conferring compression resistance 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0032931 histone H3K56 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0033691 sialic acid binding 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0043992 histone H3K9 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0043993 histone H3K18 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0043994 histone H3K23 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0043999 histone H2AK5 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044012 histone H2AK9 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044014 histone H2BK5 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044015 histone H2BK12 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044016 histone H3K4 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044017 histone H3K27 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0044018 histone H3K36 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0046972 histone H4K16 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0140035 ubiquitin-like protein reader activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0140908 histone H3K122 acetyltransferase activity 8/5150 22/18639 0.363636363636364 1.31608120035305 0.243037798450569 0.644026661271333 GO:0016407 acetyltransferase activity 30/5150 96/18639 0.3125 1.1310072815534 0.245215559970095 0.648543083318592 GO:0140297 DNA-binding transcription factor binding 142/5150 488/18639 0.290983606557377 1.053134649053 0.245890186790519 0.649074288830463 GO:0022884 macromolecule transmembrane transporter activity 11/5150 32/18639 0.34375 1.24410800970874 0.250687477337794 0.659152424343065 GO:0047498 calcium-dependent phospholipase A2 activity 11/5150 32/18639 0.34375 1.24410800970874 0.250687477337794 0.659152424343065 GO:0019894 kinesin binding 14/5150 42/18639 0.333333333333333 1.20640776699029 0.251764976155598 0.659152424343065 GO:0048487 beta-tubulin binding 14/5150 42/18639 0.333333333333333 1.20640776699029 0.251764976155598 0.659152424343065 GO:1990782 protein tyrosine kinase binding 36/5150 117/18639 0.307692307692308 1.1136071695295 0.252557036834766 0.659152424343065 GO:0070003 threonine-type peptidase activity 7/5150 19/18639 0.368421052631579 1.33339805825243 0.253557173451675 0.659152424343065 GO:0097001 ceramide binding 7/5150 19/18639 0.368421052631579 1.33339805825243 0.253557173451675 0.659152424343065 GO:0140036 ubiquitin-modified protein reader activity 7/5150 19/18639 0.368421052631579 1.33339805825243 0.253557173451675 0.659152424343065 GO:0010484 histone H3 acetyltransferase activity 10/5150 29/18639 0.344827586206897 1.24800803481754 0.262226865950071 0.676559537124522 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 68/5150 229/18639 0.296943231441048 1.07470386229703 0.262738048612629 0.676559537124522 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 39/5150 128/18639 0.3046875 1.10273209951456 0.264271521099332 0.676559537124522 GO:0003688 DNA replication origin binding 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0004707 MAP kinase activity 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0005024 transforming growth factor beta receptor activity 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0005159 insulin-like growth factor receptor binding 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0016722 oxidoreductase activity, acting on metal ions 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0097027 ubiquitin-protein transferase activator activity 6/5150 16/18639 0.375 1.35720873786408 0.264697745911492 0.676559537124522 GO:0004180 carboxypeptidase activity 15/5150 46/18639 0.326086956521739 1.18018151118615 0.272120862355456 0.686068877944882 GO:0030276 clathrin binding 15/5150 46/18639 0.326086956521739 1.18018151118615 0.272120862355456 0.686068877944882 GO:0005160 transforming growth factor beta receptor binding 9/5150 26/18639 0.346153846153846 1.25280806572069 0.274729193921926 0.686068877944882 GO:0005227 calcium-activated cation channel activity 9/5150 26/18639 0.346153846153846 1.25280806572069 0.274729193921926 0.686068877944882 GO:0019865 immunoglobulin binding 9/5150 26/18639 0.346153846153846 1.25280806572069 0.274729193921926 0.686068877944882 GO:0051139 metal cation:proton antiporter activity 9/5150 26/18639 0.346153846153846 1.25280806572069 0.274729193921926 0.686068877944882 GO:0002161 aminoacyl-tRNA editing activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0004535 poly(A)-specific ribonuclease activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0008253 5'-nucleotidase activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0015651 quaternary ammonium group transmembrane transporter activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0019104 DNA N-glycosylase activity 5/5150 13/18639 0.384615384615385 1.39200896191187 0.276410333249755 0.686068877944882 GO:0016278 lysine N-methyltransferase activity 22/5150 70/18639 0.314285714285714 1.13747018030513 0.277274477755773 0.686068877944882 GO:0097110 scaffold protein binding 22/5150 70/18639 0.314285714285714 1.13747018030513 0.277274477755773 0.686068877944882 GO:0005544 calcium-dependent phospholipid binding 17/5150 53/18639 0.320754716981132 1.16088294559443 0.278988749737969 0.686068877944882 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 37/5150 122/18639 0.30327868852459 1.09763329619608 0.282009990815542 0.686068877944882 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 19/5150 60/18639 0.316666666666667 1.14608737864078 0.284292855962915 0.686068877944882 GO:0005319 lipid transporter activity 53/5150 178/18639 0.297752808988764 1.07763390422166 0.28529904085781 0.686068877944882 GO:0140311 protein sequestering activity 11/5150 33/18639 0.333333333333333 1.20640776699029 0.288302156516304 0.686068877944882 GO:0008171 O-methyltransferase activity 8/5150 23/18639 0.347826086956522 1.25886027859856 0.288371771828982 0.686068877944882 GO:0042171 lysophosphatidic acid acyltransferase activity 8/5150 23/18639 0.347826086956522 1.25886027859856 0.288371771828982 0.686068877944882 GO:0044013 histone H2B acetyltransferase activity 8/5150 23/18639 0.347826086956522 1.25886027859856 0.288371771828982 0.686068877944882 GO:0070577 lysine-acetylated histone binding 8/5150 23/18639 0.347826086956522 1.25886027859856 0.288371771828982 0.686068877944882 GO:0071617 lysophospholipid acyltransferase activity 8/5150 23/18639 0.347826086956522 1.25886027859856 0.288371771828982 0.686068877944882 GO:0042054 histone methyltransferase activity 21/5150 67/18639 0.313432835820896 1.13438342269236 0.288447451433813 0.686068877944882 GO:0004090 carbonyl reductase (NADPH) activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0004445 inositol-polyphosphate 5-phosphatase activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0015203 polyamine transmembrane transporter activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0015279 store-operated calcium channel activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0016783 sulfurtransferase activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0016868 intramolecular phosphotransferase activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0031434 mitogen-activated protein kinase kinase binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0032356 oxidized DNA binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0033204 ribonuclease P RNA binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0042975 peroxisome proliferator activated receptor binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0070097 delta-catenin binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0071723 lipopeptide binding 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:1990757 ubiquitin ligase activator activity 4/5150 10/18639 0.4 1.44768932038835 0.288449396858578 0.686068877944882 GO:0030971 receptor tyrosine kinase binding 25/5150 81/18639 0.308641975308642 1.11704422869471 0.294340362365046 0.698867064887544 GO:0008106 alcohol dehydrogenase (NADP+) activity 10/5150 30/18639 0.333333333333333 1.20640776699029 0.302578759755712 0.714177998328346 GO:0032452 histone demethylase activity 10/5150 30/18639 0.333333333333333 1.20640776699029 0.302578759755712 0.714177998328346 GO:0140299 molecular sensor activity 22/5150 71/18639 0.309859154929577 1.12144947354027 0.303292671109851 0.714177998328346 GO:0010851 cyclase regulator activity 7/5150 20/18639 0.35 1.26672815533981 0.303395324837298 0.714177998328346 GO:0015095 magnesium ion transmembrane transporter activity 7/5150 20/18639 0.35 1.26672815533981 0.303395324837298 0.714177998328346 GO:0005504 fatty acid binding 15/5150 47/18639 0.319148936170213 1.1550712662673 0.304253884002963 0.714970533591869 GO:0019213 deacetylase activity 12/5150 37/18639 0.324324324324324 1.17380215166623 0.311871311405506 0.731615918879355 GO:0004683 calcium/calmodulin-dependent protein kinase activity 9/5150 27/18639 0.333333333333333 1.20640776699029 0.318226696748274 0.743379260031261 GO:0016790 thiolester hydrolase activity 14/5150 44/18639 0.318181818181818 1.15157105030891 0.318259435711373 0.743379260031261 GO:0008569 minus-end-directed microtubule motor activity 6/5150 17/18639 0.352941176470588 1.27737292975443 0.320141433152149 0.743379260031261 GO:0015278 intracellularly gated calcium channel activity 6/5150 17/18639 0.352941176470588 1.27737292975443 0.320141433152149 0.743379260031261 GO:0017110 nucleoside diphosphate phosphatase activity 6/5150 17/18639 0.352941176470588 1.27737292975443 0.320141433152149 0.743379260031261 GO:0051787 misfolded protein binding 6/5150 17/18639 0.352941176470588 1.27737292975443 0.320141433152149 0.743379260031261 GO:0005048 signal sequence binding 16/5150 51/18639 0.313725490196078 1.13544260422616 0.322780170255421 0.748238296531178 GO:0005518 collagen binding 22/5150 72/18639 0.305555555555556 1.10587378640777 0.33003502443406 0.763763485599091 GO:0140318 protein transporter activity 13/5150 41/18639 0.317073170731707 1.14755860762491 0.333343850519056 0.766666229107009 GO:0035035 histone acetyltransferase binding 8/5150 24/18639 0.333333333333333 1.20640776699029 0.335539158142895 0.766666229107009 GO:0140033 acetylation-dependent protein binding 8/5150 24/18639 0.333333333333333 1.20640776699029 0.335539158142895 0.766666229107009 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 15/5150 48/18639 0.3125 1.1310072815534 0.337379016674223 0.766666229107009 GO:0005545 1-phosphatidylinositol binding 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0008191 metalloendopeptidase inhibitor activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0008195 phosphatidate phosphatase activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0008474 palmitoyl-(protein) hydrolase activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0015386 potassium:proton antiporter activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0042043 neurexin family protein binding 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0044548 S100 protein binding 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0098599 palmitoyl hydrolase activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0098821 BMP receptor activity 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:1901612 cardiolipin binding 5/5150 14/18639 0.357142857142857 1.29257975034674 0.339123894042954 0.766666229107009 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 39/5150 132/18639 0.295454545454545 1.06931597528685 0.341612096487471 0.771019064559861 GO:0016279 protein-lysine N-methyltransferase activity 21/5150 69/18639 0.304347826086957 1.10150274377374 0.343211752599663 0.772002884501507 GO:1902936 phosphatidylinositol bisphosphate binding 33/5150 111/18639 0.297297297297297 1.07598530569404 0.34356085306927 0.772002884501507 GO:0016878 acid-thiol ligase activity 10/5150 31/18639 0.32258064516129 1.16749138740996 0.34430201637257 0.772002884501507 GO:0140457 protein demethylase activity 10/5150 31/18639 0.32258064516129 1.16749138740996 0.34430201637257 0.772002884501507 GO:0042162 telomeric DNA binding 12/5150 38/18639 0.315789473684211 1.14291262135922 0.34966456392776 0.781701516371045 GO:0019838 growth factor binding 40/5150 136/18639 0.294117647058824 1.06447744146202 0.35119208754825 0.781701516371045 GO:0008373 sialyltransferase activity 7/5150 21/18639 0.333333333333333 1.20640776699029 0.35492632067662 0.781701516371045 GO:0009975 cyclase activity 7/5150 21/18639 0.333333333333333 1.20640776699029 0.35492632067662 0.781701516371045 GO:0035613 RNA stem-loop binding 7/5150 21/18639 0.333333333333333 1.20640776699029 0.35492632067662 0.781701516371045 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 7/5150 21/18639 0.333333333333333 1.20640776699029 0.35492632067662 0.781701516371045 GO:0005178 integrin binding 47/5150 161/18639 0.291925465838509 1.05654344810951 0.356474840381023 0.781701516371045 GO:0000099 sulfur amino acid transmembrane transporter activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0004016 adenylate cyclase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0015217 ADP transmembrane transporter activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0019107 myristoyltransferase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0019206 nucleoside kinase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0032404 mismatch repair complex binding 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0034713 type I transforming growth factor beta receptor binding 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0035252 UDP-xylosyltransferase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0042285 xylosyltransferase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0048185 activin binding 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0140031 phosphorylation-dependent protein binding 4/5150 11/18639 0.363636363636364 1.31608120035305 0.361180335666329 0.781701516371045 GO:0016866 intramolecular transferase activity 9/5150 28/18639 0.321428571428571 1.16332177531207 0.362965182488914 0.783090236235924 GO:0051393 alpha-actinin binding 9/5150 28/18639 0.321428571428571 1.16332177531207 0.362965182488914 0.783090236235924 GO:0004725 protein tyrosine phosphatase activity 29/5150 98/18639 0.295918367346939 1.0709946502873 0.368088954095063 0.792896017468925 GO:0004402 histone acetyltransferase activity 13/5150 42/18639 0.30952380952381 1.12023578363384 0.369913690750952 0.794328771675241 GO:0035198 miRNA binding 13/5150 42/18639 0.30952380952381 1.12023578363384 0.369913690750952 0.794328771675241 GO:0030170 pyridoxal phosphate binding 17/5150 56/18639 0.303571428571429 1.09869278779473 0.371775833286594 0.797078077625406 GO:0000900 mRNA regulatory element binding translation repressor activity 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0008409 5'-3' exonuclease activity 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0031690 adrenergic receptor binding 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0035615 clathrin adaptor activity 6/5150 18/18639 0.333333333333333 1.20640776699029 0.376989920079363 0.800738279858492 GO:0000030 mannosyltransferase activity 8/5150 25/18639 0.32 1.15815145631068 0.383734537262759 0.813802346826595 GO:0035064 methylated histone binding 22/5150 74/18639 0.297297297297297 1.07598530569404 0.385128339348908 0.815495865391042 GO:0005246 calcium channel regulator activity 16/5150 53/18639 0.30188679245283 1.09259571350064 0.388103251196553 0.818127527882214 GO:0034212 protein N-acetyltransferase activity 16/5150 53/18639 0.30188679245283 1.09259571350064 0.388103251196553 0.818127527882214 GO:0000217 DNA secondary structure binding 12/5150 39/18639 0.307692307692308 1.1136071695295 0.38816269571054 0.818127527882214 GO:0140375 immune receptor activity 45/5150 156/18639 0.288461538461538 1.04400672143391 0.396125870129257 0.831155233515614 GO:0004865 protein serine/threonine phosphatase inhibitor activity 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0004953 icosanoid receptor activity 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0005523 tropomyosin binding 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0016846 carbon-sulfur lyase activity 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0050780 dopamine receptor binding 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0061578 K63-linked deubiquitinase activity 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0120283 protein serine/threonine kinase binding 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0140776 protein-containing complex destabilizing activity 5/5150 15/18639 0.333333333333333 1.20640776699029 0.40266914608533 0.831155233515614 GO:0015297 antiporter activity 39/5150 135/18639 0.288888888888889 1.04555339805825 0.403242596167209 0.831155233515614 GO:0070279 vitamin B6 binding 17/5150 57/18639 0.298245614035088 1.07941747572816 0.403841096713993 0.831155233515614 GO:0004896 cytokine receptor activity 28/5150 96/18639 0.291666666666667 1.0556067961165 0.40554990805569 0.831155233515614 GO:0048156 tau protein binding 13/5150 43/18639 0.302325581395349 1.09418378866561 0.4069692410725 0.831155233515614 GO:0003774 cytoskeletal motor activity 44/5150 153/18639 0.287581699346405 1.04082238720731 0.407075137247937 0.831155233515614 GO:0008970 phospholipase A1 activity 7/5150 22/18639 0.318181818181818 1.15157105030891 0.407140964382111 0.831155233515614 GO:0050321 tau-protein kinase activity 7/5150 22/18639 0.318181818181818 1.15157105030891 0.407140964382111 0.831155233515614 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 26/5150 89/18639 0.292134831460674 1.05730118904767 0.408036322405967 0.831155233515614 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 26/5150 89/18639 0.292134831460674 1.05730118904767 0.408036322405967 0.831155233515614 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 9/5150 29/18639 0.310344827586207 1.12320723133579 0.408297424931393 0.831155233515614 GO:0016417 S-acyltransferase activity 9/5150 29/18639 0.310344827586207 1.12320723133579 0.408297424931393 0.831155233515614 GO:0043236 laminin binding 9/5150 29/18639 0.310344827586207 1.12320723133579 0.408297424931393 0.831155233515614 GO:0097472 cyclin-dependent protein kinase activity 9/5150 29/18639 0.310344827586207 1.12320723133579 0.408297424931393 0.831155233515614 GO:0099604 ligand-gated calcium channel activity 9/5150 29/18639 0.310344827586207 1.12320723133579 0.408297424931393 0.831155233515614 GO:0070851 growth factor receptor binding 40/5150 139/18639 0.287769784172662 1.04150310819306 0.412327679169313 0.838114125314478 GO:0015026 coreceptor activity 18/5150 61/18639 0.295081967213115 1.06796753143403 0.418579932150528 0.849562232661072 GO:0051213 dioxygenase activity 27/5150 93/18639 0.290322580645161 1.05074224866896 0.419437522331428 0.850043499399492 GO:0043495 protein-membrane adaptor activity 14/5150 47/18639 0.297872340425532 1.07806651518281 0.424164800401729 0.850534571794105 GO:0033218 amide binding 70/5150 247/18639 0.283400809716599 1.02569081404033 0.424834441512207 0.850534571794105 GO:0000995 RNA polymerase III general transcription initiation factor activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0004526 ribonuclease P activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0004859 phospholipase inhibitor activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0008504 monoamine transmembrane transporter activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0010853 cyclase activator activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0015368 calcium:monoatomic cation antiporter activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0035014 phosphatidylinositol 3-kinase regulator activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0035197 siRNA binding 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0035251 UDP-glucosyltransferase activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0045295 gamma-catenin binding 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/5150 12/18639 0.333333333333333 1.20640776699029 0.433558903461229 0.850534571794105 GO:0140793 histone H2AXY142 phosphatase activity 26/5150 90/18639 0.288888888888889 1.04555339805825 0.433876397469805 0.850534571794105 GO:0005229 intracellularly calcium-gated chloride channel activity 6/5150 19/18639 0.315789473684211 1.14291262135922 0.433958880061372 0.850534571794105 GO:0022821 solute:potassium antiporter activity 6/5150 19/18639 0.315789473684211 1.14291262135922 0.433958880061372 0.850534571794105 GO:0042577 lipid phosphatase activity 6/5150 19/18639 0.315789473684211 1.14291262135922 0.433958880061372 0.850534571794105 GO:0046624 sphingolipid transporter activity 6/5150 19/18639 0.315789473684211 1.14291262135922 0.433958880061372 0.850534571794105 GO:0141147 intracellularly calcium-gated channel activity 6/5150 19/18639 0.315789473684211 1.14291262135922 0.433958880061372 0.850534571794105 GO:0030246 carbohydrate binding 79/5150 280/18639 0.282142857142857 1.02113800277393 0.435512182523374 0.852359557224318 GO:0001540 amyloid-beta binding 24/5150 83/18639 0.289156626506024 1.04652240028073 0.437530914963501 0.855088949358056 GO:0140034 methylation-dependent protein binding 22/5150 76/18639 0.289473684210526 1.04766990291262 0.441394932892462 0.861411763622042 GO:0008080 N-acetyltransferase activity 20/5150 69/18639 0.289855072463768 1.04905023216547 0.445505419588052 0.868196905882833 GO:0005200 structural constituent of cytoskeleton 32/5150 112/18639 0.285714285714286 1.03406380027739 0.447171803503221 0.870206492612802 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 9/5150 30/18639 0.3 1.08576699029126 0.453605424292399 0.880225823343607 GO:0022839 monoatomic ion-gated channel activity 9/5150 30/18639 0.3 1.08576699029126 0.453605424292399 0.880225823343607 GO:0016849 phosphorus-oxygen lyase activity 7/5150 23/18639 0.304347826086957 1.10150274377374 0.459102486124104 0.884627856526051 GO:0017134 fibroblast growth factor binding 7/5150 23/18639 0.304347826086957 1.10150274377374 0.459102486124104 0.884627856526051 GO:0031681 G-protein beta-subunit binding 7/5150 23/18639 0.304347826086957 1.10150274377374 0.459102486124104 0.884627856526051 GO:0099186 structural constituent of postsynapse 7/5150 23/18639 0.304347826086957 1.10150274377374 0.459102486124104 0.884627856526051 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 7/5150 23/18639 0.304347826086957 1.10150274377374 0.459102486124104 0.884627856526051 GO:0042826 histone deacetylase binding 36/5150 127/18639 0.283464566929134 1.02592156562954 0.461720298687775 0.886752828764283 GO:0008235 metalloexopeptidase activity 19/5150 66/18639 0.287878787878788 1.04189761694616 0.462884520518607 0.886752828764283 GO:0008296 3'-5'-DNA exonuclease activity 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0030275 LRR domain binding 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0055102 lipase inhibitor activity 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0070411 I-SMAD binding 5/5150 16/18639 0.3125 1.1310072815534 0.46538341889162 0.886752828764283 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 10/5150 34/18639 0.294117647058824 1.06447744146202 0.472343562851086 0.898764834869427 GO:0016782 transferase activity, transferring sulphur-containing groups 20/5150 70/18639 0.285714285714286 1.03406380027739 0.475119353553028 0.901871280796539 GO:0004197 cysteine-type endopeptidase activity 25/5150 88/18639 0.284090909090909 1.02818843777582 0.475292747981826 0.901871280796539 GO:0031490 chromatin DNA binding 36/5150 128/18639 0.28125 1.01790655339806 0.483625420786837 0.91641331463066 GO:0022804 active transmembrane transporter activity 127/5150 457/18639 0.277899343544858 1.00577977948206 0.487295553450516 0.921954841397078 GO:0005201 extracellular matrix structural constituent 47/5150 168/18639 0.279761904761905 1.01252080443828 0.489311546798447 0.921954841397078 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 6/5150 20/18639 0.3 1.08576699029126 0.489914689443119 0.921954841397078 GO:0031418 L-ascorbic acid binding 6/5150 20/18639 0.3 1.08576699029126 0.489914689443119 0.921954841397078 GO:0043024 ribosomal small subunit binding 6/5150 20/18639 0.3 1.08576699029126 0.489914689443119 0.921954841397078 GO:0016411 acylglycerol O-acyltransferase activity 9/5150 31/18639 0.290322580645161 1.05074224866896 0.498320454805056 0.93323642225768 GO:0072349 modified amino acid transmembrane transporter activity 9/5150 31/18639 0.290322580645161 1.05074224866896 0.498320454805056 0.93323642225768 GO:0002020 protease binding 38/5150 136/18639 0.279411764705882 1.01125356938892 0.500252708527438 0.93323642225768 GO:0005542 folic acid binding 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0009982 pseudouridine synthase activity 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0045159 myosin II binding 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0046974 histone H3K9 methyltransferase activity 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0070700 BMP receptor binding 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0089720 caspase binding 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/5150 13/18639 0.307692307692308 1.1136071695295 0.503402712444106 0.93323642225768 GO:0008234 cysteine-type peptidase activity 52/5150 187/18639 0.27807486631016 1.00641503556409 0.506242578284407 0.936561206211178 GO:0004806 triacylglycerol lipase activity 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0005315 phosphate transmembrane transporter activity 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0042625 ATPase-coupled ion transmembrane transporter activity 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0046961 proton-transporting ATPase activity, rotational mechanism 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0050699 WW domain binding 7/5150 24/18639 0.291666666666667 1.0556067961165 0.509981503528131 0.936561206211178 GO:0101005 deubiquitinase activity 32/5150 115/18639 0.278260869565217 1.00708822287885 0.5167470855729 0.947715538467031 GO:0033293 monocarboxylic acid binding 22/5150 79/18639 0.278481012658228 1.00788496989062 0.525477838946238 0.947940888578701 GO:0004659 prenyltransferase activity 5/5150 17/18639 0.294117647058824 1.06447744146202 0.525900912949734 0.947940888578701 GO:0016805 dipeptidase activity 5/5150 17/18639 0.294117647058824 1.06447744146202 0.525900912949734 0.947940888578701 GO:0036041 long-chain fatty acid binding 5/5150 17/18639 0.294117647058824 1.06447744146202 0.525900912949734 0.947940888578701 GO:0070492 oligosaccharide binding 5/5150 17/18639 0.294117647058824 1.06447744146202 0.525900912949734 0.947940888578701 GO:0019789 SUMO transferase activity 8/5150 28/18639 0.285714285714286 1.03406380027739 0.527041099271678 0.947940888578701 GO:0050698 proteoglycan sulfotransferase activity 8/5150 28/18639 0.285714285714286 1.03406380027739 0.527041099271678 0.947940888578701 GO:0097718 disordered domain specific binding 8/5150 28/18639 0.285714285714286 1.03406380027739 0.527041099271678 0.947940888578701 GO:0016410 N-acyltransferase activity 26/5150 94/18639 0.276595744680851 1.00106176409833 0.536708691559089 0.947940888578701 GO:0004712 protein serine/threonine/tyrosine kinase activity 12/5150 43/18639 0.27906976744186 1.0100158049221 0.541610673200239 0.947940888578701 GO:0008375 acetylglucosaminyltransferase activity 12/5150 43/18639 0.27906976744186 1.0100158049221 0.541610673200239 0.947940888578701 GO:0120015 sterol transfer activity 9/5150 32/18639 0.28125 1.01790655339806 0.541937732070871 0.947940888578701 GO:0043177 organic acid binding 52/5150 189/18639 0.275132275132275 0.995765141007859 0.542218295260569 0.947940888578701 GO:0061891 calcium ion sensor activity 6/5150 21/18639 0.285714285714286 1.03406380027739 0.543910036949719 0.947940888578701 GO:0008081 phosphoric diester hydrolase activity 24/5150 87/18639 0.275862068965517 0.998406427854034 0.54444078289174 0.947940888578701 GO:0099106 ion channel regulator activity 44/5150 160/18639 0.275 0.99528640776699 0.544921211017691 0.947940888578701 GO:0000182 rDNA binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0004955 prostaglandin receptor activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0005131 growth hormone receptor binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0005522 profilin binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0005528 FK506 binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0008140 cAMP response element binding protein binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0015187 glycine transmembrane transporter activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0015643 toxic substance binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0019911 structural constituent of myelin sheath 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0030957 Tat protein binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0031419 cobalamin binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0031956 medium-chain fatty acid-CoA ligase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0035374 chondroitin sulfate binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0043208 glycosphingolipid binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0043295 glutathione binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0045322 unmethylated CpG binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0050308 sugar-phosphatase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0070739 protein-glutamic acid ligase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0070740 tubulin-glutamic acid ligase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0140999 histone H3K4 trimethyltransferase activity 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:1990763 arrestin family protein binding 3/5150 10/18639 0.3 1.08576699029126 0.551691024806819 0.947940888578701 GO:0002039 p53 binding 19/5150 69/18639 0.27536231884058 0.996597720557197 0.55268350450904 0.947940888578701 GO:0061980 regulatory RNA binding 16/5150 58/18639 0.275862068965517 0.998406427854034 0.552814355031683 0.947940888578701 GO:0061733 protein-lysine-acetyltransferase activity 13/5150 47/18639 0.276595744680851 1.00106176409833 0.553499260173769 0.947940888578701 GO:0140938 histone H3 methyltransferase activity 13/5150 47/18639 0.276595744680851 1.00106176409833 0.553499260173769 0.947940888578701 GO:0004033 aldo-keto reductase (NADPH) activity 10/5150 36/18639 0.277777777777778 1.00533980582524 0.555202503414144 0.947940888578701 GO:0016409 palmitoyltransferase activity 10/5150 36/18639 0.277777777777778 1.00533980582524 0.555202503414144 0.947940888578701 GO:0016247 channel regulator activity 46/5150 168/18639 0.273809523809524 0.990977808599168 0.558327062375319 0.947940888578701 GO:0004709 MAP kinase kinase kinase activity 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0005537 D-mannose binding 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0008139 nuclear localization sequence binding 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0008483 transaminase activity 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0019706 protein-cysteine S-palmitoyltransferase activity 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0019707 protein-cysteine S-acyltransferase activity 7/5150 25/18639 0.28 1.01338252427184 0.559077545964665 0.947940888578701 GO:0008013 beta-catenin binding 29/5150 106/18639 0.273584905660377 0.990164865359956 0.561909686396083 0.951565229125629 GO:0004065 arylsulfatase activity 4/5150 14/18639 0.285714285714286 1.03406380027739 0.569114239804567 0.959023995734633 GO:0030983 mismatched DNA binding 4/5150 14/18639 0.285714285714286 1.03406380027739 0.569114239804567 0.959023995734633 GO:0032454 histone H3K9 demethylase activity 4/5150 14/18639 0.285714285714286 1.03406380027739 0.569114239804567 0.959023995734633 GO:0070742 C2H2 zinc finger domain binding 4/5150 14/18639 0.285714285714286 1.03406380027739 0.569114239804567 0.959023995734633 GO:0031406 carboxylic acid binding 51/5150 187/18639 0.272727272727273 0.987060900264784 0.571561226478333 0.959631817731288 GO:0003785 actin monomer binding 8/5150 29/18639 0.275862068965517 0.998406427854034 0.572276784734644 0.959631817731288 GO:0004181 metallocarboxypeptidase activity 8/5150 29/18639 0.275862068965517 0.998406427854034 0.572276784734644 0.959631817731288 GO:0051861 glycolipid binding 8/5150 29/18639 0.275862068965517 0.998406427854034 0.572276784734644 0.959631817731288 GO:0015101 organic cation transmembrane transporter activity 22/5150 81/18639 0.271604938271605 0.982998921251348 0.579774642784829 0.970942010697665 GO:0000400 four-way junction DNA binding 5/5150 18/18639 0.277777777777778 1.00533980582524 0.58317437174603 0.970942010697665 GO:0004706 JUN kinase kinase kinase activity 5/5150 18/18639 0.277777777777778 1.00533980582524 0.58317437174603 0.970942010697665 GO:0017128 phospholipid scramblase activity 5/5150 18/18639 0.277777777777778 1.00533980582524 0.58317437174603 0.970942010697665 GO:1990381 ubiquitin-specific protease binding 5/5150 18/18639 0.277777777777778 1.00533980582524 0.58317437174603 0.970942010697665 GO:0008237 metallopeptidase activity 50/5150 184/18639 0.271739130434783 0.983484592655129 0.583273923214729 0.970942010697665 GO:0048029 monosaccharide binding 20/5150 74/18639 0.27027027027027 0.978168459721858 0.590143431543822 0.981185074290093 GO:0042805 actinin binding 10/5150 37/18639 0.27027027027027 0.978168459721858 0.594657427798727 0.982814646268722 GO:0004407 histone deacetylase activity 6/5150 22/18639 0.272727272727273 0.987060900264784 0.595198439162572 0.982814646268722 GO:0033558 protein lysine deacetylase activity 6/5150 22/18639 0.272727272727273 0.987060900264784 0.595198439162572 0.982814646268722 GO:0070034 telomerase RNA binding 6/5150 22/18639 0.272727272727273 0.987060900264784 0.595198439162572 0.982814646268722 GO:0140784 metal ion sensor activity 6/5150 22/18639 0.272727272727273 0.987060900264784 0.595198439162572 0.982814646268722 GO:0141108 transporter regulator activity 46/5150 170/18639 0.270588235294118 0.97931924614506 0.59542785138908 0.982814646268722 GO:0005080 protein kinase C binding 14/5150 52/18639 0.269230769230769 0.974406273338312 0.597667882428373 0.985324908455922 GO:0001727 lipid kinase activity 11/5150 41/18639 0.268292682926829 0.971011129528771 0.604398061783123 0.989742864630893 GO:0017080 sodium channel regulator activity 11/5150 41/18639 0.268292682926829 0.971011129528771 0.604398061783123 0.989742864630893 GO:0042287 MHC protein binding 11/5150 41/18639 0.268292682926829 0.971011129528771 0.604398061783123 0.989742864630893 GO:0004529 DNA exonuclease activity 7/5150 26/18639 0.269230769230769 0.974406273338312 0.605828773652832 0.989742864630893 GO:0005112 Notch binding 7/5150 26/18639 0.269230769230769 0.974406273338312 0.605828773652832 0.989742864630893 GO:0008157 protein phosphatase 1 binding 7/5150 26/18639 0.269230769230769 0.974406273338312 0.605828773652832 0.989742864630893 GO:0051087 protein-folding chaperone binding 36/5150 134/18639 0.26865671641791 0.972328648022026 0.611141434112647 0.989742864630893 GO:0016769 transferase activity, transferring nitrogenous groups 8/5150 30/18639 0.266666666666667 0.965126213592233 0.615430006713643 0.989742864630893 GO:0098918 structural constituent of synapse 8/5150 30/18639 0.266666666666667 0.965126213592233 0.615430006713643 0.989742864630893 GO:0035254 glutamate receptor binding 13/5150 49/18639 0.26530612244898 0.960202100257579 0.621810176519623 0.989742864630893 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0004954 prostanoid receptor activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0005114 type II transforming growth factor beta receptor binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0005225 volume-sensitive anion channel activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0008046 axon guidance receptor activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0015173 aromatic amino acid transmembrane transporter activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0019203 carbohydrate phosphatase activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0019864 IgG binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0032794 GTPase activating protein binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0034511 U3 snoRNA binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0045294 alpha-catenin binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0050998 nitric-oxide synthase binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0097493 structural molecule activity conferring elasticity 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:1900750 oligopeptide binding 3/5150 11/18639 0.272727272727273 0.987060900264784 0.623132533234503 0.989742864630893 GO:0016831 carboxy-lyase activity 9/5150 34/18639 0.264705882352941 0.958029697315819 0.624231478044693 0.989742864630893 GO:0004467 long-chain fatty acid-CoA ligase activity 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0015556 C4-dicarboxylate transmembrane transporter activity 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0033130 acetylcholine receptor binding 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0042809 nuclear vitamin D receptor binding 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0047372 monoacylglycerol lipase activity 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0141050 histone H3K deacetylase activity 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0141051 histone H4K deacetylase activity 4/5150 15/18639 0.266666666666667 0.965126213592233 0.629639728429743 0.989742864630893 GO:0003777 microtubule motor activity 18/5150 68/18639 0.264705882352941 0.958029697315819 0.629967721137327 0.989742864630893 GO:0000146 microfilament motor activity 10/5150 38/18639 0.263157894736842 0.952427184466019 0.632388127083011 0.992407484654897 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/5150 19/18639 0.263157894736842 0.952427184466019 0.636465618776265 0.995385727994844 GO:0016918 retinal binding 5/5150 19/18639 0.263157894736842 0.952427184466019 0.636465618776265 0.995385727994844 GO:1990380 K48-linked deubiquitinase activity 5/5150 19/18639 0.263157894736842 0.952427184466019 0.636465618776265 0.995385727994844 GO:0008238 exopeptidase activity 27/5150 102/18639 0.264705882352941 0.958029697315819 0.640250035013598 1 GO:0016853 isomerase activity 48/5150 180/18639 0.266666666666667 0.965126213592233 0.641881658643306 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 6/5150 23/18639 0.260869565217391 0.944145208948924 0.643232304940855 1 GO:0051082 unfolded protein binding 32/5150 121/18639 0.264462809917355 0.957149963893124 0.648447402101335 1 GO:0001671 ATPase activator activity 7/5150 27/18639 0.259259259259259 0.93831715210356 0.649812051364512 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 7/5150 27/18639 0.259259259259259 0.93831715210356 0.649812051364512 1 GO:0019955 cytokine binding 38/5150 144/18639 0.263888888888889 0.955072815533981 0.661452549271577 1 GO:0016229 steroid dehydrogenase activity 9/5150 35/18639 0.257142857142857 0.930657420249653 0.662279914179522 1 GO:0003714 transcription corepressor activity 54/5150 204/18639 0.264705882352941 0.958029697315819 0.670684702376834 1 GO:0005245 voltage-gated calcium channel activity 11/5150 43/18639 0.255813953488372 0.925847821178596 0.67383516193164 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 11/5150 43/18639 0.255813953488372 0.925847821178596 0.67383516193164 1 GO:0015562 efflux transmembrane transporter activity 4/5150 16/18639 0.25 0.904805825242718 0.684391831609118 1 GO:0017070 U6 snRNA binding 4/5150 16/18639 0.25 0.904805825242718 0.684391831609118 1 GO:0019841 retinol binding 4/5150 16/18639 0.25 0.904805825242718 0.684391831609118 1 GO:0022858 alanine transmembrane transporter activity 4/5150 16/18639 0.25 0.904805825242718 0.684391831609118 1 GO:0030544 Hsp70 protein binding 13/5150 51/18639 0.254901960784314 0.922547115933752 0.68457085695938 1 GO:0000339 RNA cap binding 5/5150 20/18639 0.25 0.904805825242718 0.68531592855398 1 GO:0042288 MHC class I protein binding 5/5150 20/18639 0.25 0.904805825242718 0.68531592855398 1 GO:0140664 ATP-dependent DNA damage sensor activity 5/5150 20/18639 0.25 0.904805825242718 0.68531592855398 1 GO:0004875 complement receptor activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0005165 neurotrophin receptor binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0005527 macrolide binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0015132 prostaglandin transmembrane transporter activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0015269 calcium-activated potassium channel activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0016208 AMP binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0016273 arginine N-methyltransferase activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0016274 protein-arginine N-methyltransferase activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0031543 peptidyl-proline dioxygenase activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0042301 phosphate ion binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0070008 serine-type exopeptidase activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0070410 co-SMAD binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0070679 inositol 1,4,5 trisphosphate binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0097677 STAT family protein binding 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:1990817 poly(A) RNA polymerase activity 3/5150 12/18639 0.25 0.904805825242718 0.686323743158927 1 GO:0015295 solute:proton symporter activity 6/5150 24/18639 0.25 0.904805825242718 0.687649238745096 1 GO:0050431 transforming growth factor beta binding 6/5150 24/18639 0.25 0.904805825242718 0.687649238745096 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/5150 24/18639 0.25 0.904805825242718 0.687649238745096 1 GO:0070840 dynein complex binding 6/5150 24/18639 0.25 0.904805825242718 0.687649238745096 1 GO:0140612 DNA damage sensor activity 6/5150 24/18639 0.25 0.904805825242718 0.687649238745096 1 GO:0098632 cell-cell adhesion mediator activity 14/5150 55/18639 0.254545454545455 0.921256840247131 0.689663914967437 1 GO:0031369 translation initiation factor binding 8/5150 32/18639 0.25 0.904805825242718 0.694239107842028 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 10/5150 40/18639 0.25 0.904805825242718 0.70182524409604 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 22/5150 86/18639 0.255813953488372 0.925847821178596 0.70321025945994 1 GO:0050840 extracellular matrix binding 17/5150 67/18639 0.253731343283582 0.91831038979858 0.703982496827701 1 GO:0140693 molecular condensate scaffold activity 12/5150 48/18639 0.25 0.904805825242718 0.709643558239113 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 13/5150 52/18639 0.25 0.904805825242718 0.713538515136383 1 GO:0004536 DNA nuclease activity 16/5150 64/18639 0.25 0.904805825242718 0.724960707413529 1 GO:0015645 fatty acid ligase activity 6/5150 25/18639 0.24 0.86861359223301 0.728250825938917 1 GO:0120515 fatty acid-CoA ligase activity 6/5150 25/18639 0.24 0.86861359223301 0.728250825938917 1 GO:1904047 S-adenosyl-L-methionine binding 5/5150 21/18639 0.238095238095238 0.861719833564494 0.729505269680312 1 GO:0030296 protein tyrosine kinase activator activity 8/5150 33/18639 0.242424242424242 0.87738746690203 0.729507349252398 1 GO:0140416 transcription regulator inhibitor activity 8/5150 33/18639 0.242424242424242 0.87738746690203 0.729507349252398 1 GO:0023023 MHC protein complex binding 9/5150 37/18639 0.243243243243243 0.880351613749672 0.731180763353337 1 GO:0043394 proteoglycan binding 9/5150 37/18639 0.243243243243243 0.880351613749672 0.731180763353337 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/5150 17/18639 0.235294117647059 0.851581953169617 0.733158268119697 1 GO:0008484 sulfuric ester hydrolase activity 4/5150 17/18639 0.235294117647059 0.851581953169617 0.733158268119697 1 GO:0030169 low-density lipoprotein particle binding 4/5150 17/18639 0.235294117647059 0.851581953169617 0.733158268119697 1 GO:0045125 bioactive lipid receptor activity 4/5150 17/18639 0.235294117647059 0.851581953169617 0.733158268119697 1 GO:0005004 GPI-linked ephrin receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0005008 hepatocyte growth factor receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0005009 insulin receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0005011 macrophage colony-stimulating factor receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0005020 stem cell factor receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0008288 boss receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0036332 placental growth factor receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0038062 protein tyrosine kinase collagen receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0060175 brain-derived neurotrophic factor receptor activity 12/5150 49/18639 0.244897959183673 0.886340400237765 0.738130060418406 1 GO:0004465 lipoprotein lipase activity 3/5150 13/18639 0.230769230769231 0.835205377147125 0.741200052373374 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/5150 13/18639 0.230769230769231 0.835205377147125 0.741200052373374 1 GO:0071714 icosanoid transmembrane transporter activity 3/5150 13/18639 0.230769230769231 0.835205377147125 0.741200052373374 1 GO:0140666 annealing activity 3/5150 13/18639 0.230769230769231 0.835205377147125 0.741200052373374 1 GO:0008376 acetylgalactosaminyltransferase activity 8/5150 34/18639 0.235294117647059 0.851581953169617 0.761899925008615 1 GO:0004843 cysteine-type deubiquitinase activity 27/5150 108/18639 0.25 0.904805825242718 0.762080854938833 1 GO:0004520 DNA endonuclease activity 10/5150 42/18639 0.238095238095238 0.861719833564494 0.762391828267008 1 GO:0016859 cis-trans isomerase activity 10/5150 42/18639 0.238095238095238 0.861719833564494 0.762391828267008 1 GO:0051879 Hsp90 protein binding 10/5150 42/18639 0.238095238095238 0.861719833564494 0.762391828267008 1 GO:0033612 receptor serine/threonine kinase binding 7/5150 30/18639 0.233333333333333 0.844485436893204 0.762817618509627 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 11/5150 46/18639 0.239130434782609 0.865466441536513 0.763387090491975 1 GO:0005006 epidermal growth factor receptor activity 12/5150 50/18639 0.24 0.86861359223301 0.764710311456708 1 GO:0005007 fibroblast growth factor receptor activity 12/5150 50/18639 0.24 0.86861359223301 0.764710311456708 1 GO:0005017 platelet-derived growth factor receptor activity 12/5150 50/18639 0.24 0.86861359223301 0.764710311456708 1 GO:0005019 platelet-derived growth factor beta-receptor activity 12/5150 50/18639 0.24 0.86861359223301 0.764710311456708 1 GO:0050750 low-density lipoprotein particle receptor binding 6/5150 26/18639 0.230769230769231 0.835205377147125 0.764977441624742 1 GO:0070006 metalloaminopeptidase activity 6/5150 26/18639 0.230769230769231 0.835205377147125 0.764977441624742 1 GO:0017069 snRNA binding 13/5150 54/18639 0.240740740740741 0.871294498381877 0.766278480120777 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 13/5150 54/18639 0.240740740740741 0.871294498381877 0.766278480120777 1 GO:0017116 single-stranded DNA helicase activity 14/5150 58/18639 0.241379310344828 0.87360562437228 0.76803083765528 1 GO:0016881 acid-amino acid ligase activity 5/5150 22/18639 0.227272727272727 0.822550750220653 0.769007278656118 1 GO:0140104 molecular carrier activity 64/5150 249/18639 0.257028112449799 0.930242133582875 0.773838295628785 1 GO:0003746 translation elongation factor activity 4/5150 18/18639 0.222222222222222 0.804271844660194 0.776010809940745 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/5150 18/18639 0.222222222222222 0.804271844660194 0.776010809940745 1 GO:0015172 acidic amino acid transmembrane transporter activity 4/5150 18/18639 0.222222222222222 0.804271844660194 0.776010809940745 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/5150 18/18639 0.222222222222222 0.804271844660194 0.776010809940745 1 GO:0032393 MHC class I receptor activity 4/5150 18/18639 0.222222222222222 0.804271844660194 0.776010809940745 1 GO:0005313 L-glutamate transmembrane transporter activity 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:0008174 mRNA methyltransferase activity 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:0015926 glucosidase activity 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:0061665 SUMO ligase activity 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:1901474 azole transmembrane transporter activity 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:1990825 sequence-specific mRNA binding 3/5150 14/18639 0.214285714285714 0.775547850208044 0.788132546710321 1 GO:0061749 forked DNA-dependent helicase activity 11/5150 47/18639 0.234042553191489 0.847052261929354 0.789080724981039 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 11/5150 47/18639 0.234042553191489 0.847052261929354 0.789080724981039 1 GO:0005010 insulin-like growth factor receptor activity 12/5150 51/18639 0.235294117647059 0.851581953169617 0.789368605148194 1 GO:0005021 vascular endothelial growth factor receptor activity 12/5150 51/18639 0.235294117647059 0.851581953169617 0.789368605148194 1 GO:0005030 neurotrophin receptor activity 12/5150 51/18639 0.235294117647059 0.851581953169617 0.789368605148194 1 GO:0016597 amino acid binding 12/5150 51/18639 0.235294117647059 0.851581953169617 0.789368605148194 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 9/5150 39/18639 0.230769230769231 0.835205377147125 0.78994273893352 1 GO:0008374 O-acyltransferase activity 13/5150 55/18639 0.236363636363636 0.855452780229479 0.78999251219205 1 GO:0015459 potassium channel regulator activity 14/5150 59/18639 0.23728813559322 0.858798749382919 0.790879158664332 1 GO:0070888 E-box binding 14/5150 59/18639 0.23728813559322 0.858798749382919 0.790879158664332 1 GO:0008266 poly(U) RNA binding 6/5150 27/18639 0.222222222222222 0.804271844660194 0.797881838841951 1 GO:0016405 CoA-ligase activity 6/5150 27/18639 0.222222222222222 0.804271844660194 0.797881838841951 1 GO:0016757 glycosyltransferase activity 68/5150 267/18639 0.254681647940075 0.92174975455438 0.805701933376725 1 GO:0001094 TFIID-class transcription factor complex binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0004382 GDP phosphatase activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0005337 nucleoside transmembrane transporter activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0005381 iron ion transmembrane transporter activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0008519 ammonium channel activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0032052 bile acid binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0043121 neurotrophin binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0043422 protein kinase B binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0051880 G-quadruplex DNA binding 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0140135 mechanosensitive monoatomic cation channel activity 2/5150 10/18639 0.2 0.723844660194175 0.81021547323326 1 GO:0061134 peptidase regulator activity 57/5150 226/18639 0.252212389380531 0.912812956439557 0.812570720418096 1 GO:0009378 four-way junction helicase activity 11/5150 48/18639 0.229166666666667 0.829405339805825 0.812697179958368 1 GO:0036121 double-stranded DNA helicase activity 11/5150 48/18639 0.229166666666667 0.829405339805825 0.812697179958368 1 GO:0043138 3'-5' DNA helicase activity 11/5150 48/18639 0.229166666666667 0.829405339805825 0.812697179958368 1 GO:0030506 ankyrin binding 4/5150 19/18639 0.210526315789474 0.761941747572816 0.813222860917939 1 GO:0042834 peptidoglycan binding 4/5150 19/18639 0.210526315789474 0.761941747572816 0.813222860917939 1 GO:0046527 glucosyltransferase activity 4/5150 19/18639 0.210526315789474 0.761941747572816 0.813222860917939 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/5150 36/18639 0.222222222222222 0.804271844660194 0.818115416917022 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/5150 36/18639 0.222222222222222 0.804271844660194 0.818115416917022 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/5150 36/18639 0.222222222222222 0.804271844660194 0.818115416917022 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/5150 36/18639 0.222222222222222 0.804271844660194 0.818115416917022 1 GO:0031072 heat shock protein binding 32/5150 131/18639 0.244274809160305 0.884085081153191 0.820841927509051 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/5150 32/18639 0.21875 0.791705097087379 0.8218370405511 1 GO:0004089 carbonate dehydratase activity 3/5150 15/18639 0.2 0.723844660194175 0.827755751280465 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/5150 15/18639 0.2 0.723844660194175 0.827755751280465 1 GO:0008242 omega peptidase activity 3/5150 15/18639 0.2 0.723844660194175 0.827755751280465 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 3/5150 15/18639 0.2 0.723844660194175 0.827755751280465 1 GO:0034483 heparan sulfate sulfotransferase activity 3/5150 15/18639 0.2 0.723844660194175 0.827755751280465 1 GO:0005003 ephrin receptor activity 12/5150 53/18639 0.226415094339623 0.819446785125481 0.832994387787231 1 GO:0005005 transmembrane-ephrin receptor activity 12/5150 53/18639 0.226415094339623 0.819446785125481 0.832994387787231 1 GO:0038064 collagen receptor activity 12/5150 53/18639 0.226415094339623 0.819446785125481 0.832994387787231 1 GO:0003727 single-stranded RNA binding 21/5150 89/18639 0.235955056179775 0.853974037307734 0.83431980663718 1 GO:0005540 hyaluronic acid binding 5/5150 24/18639 0.208333333333333 0.754004854368932 0.834548858883671 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/5150 41/18639 0.219512195121951 0.794463651432631 0.838664200875581 1 GO:0019956 chemokine binding 7/5150 33/18639 0.212121212121212 0.767714033539276 0.846695034362289 1 GO:0019199 transmembrane receptor protein kinase activity 18/5150 78/18639 0.230769230769231 0.835205377147125 0.848429380970055 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0005536 D-glucose binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0008199 ferric iron binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0015205 nucleobase transmembrane transporter activity 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0019215 intermediate filament binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0043522 leucine zipper domain binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0047676 arachidonate-CoA ligase activity 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0070697 activin receptor binding 2/5150 11/18639 0.181818181818182 0.658040600176523 0.85178945989965 1 GO:0035250 UDP-galactosyltransferase activity 6/5150 29/18639 0.206896551724138 0.748804820890526 0.852845165574901 1 GO:0008307 structural constituent of muscle 9/5150 42/18639 0.214285714285714 0.775547850208044 0.859465757041556 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 3/5150 16/18639 0.1875 0.678604368932039 0.860839732743084 1 GO:0005521 lamin binding 3/5150 16/18639 0.1875 0.678604368932039 0.860839732743084 1 GO:0015378 sodium:chloride symporter activity 3/5150 16/18639 0.1875 0.678604368932039 0.860839732743084 1 GO:0015662 P-type ion transporter activity 5/5150 25/18639 0.2 0.723844660194175 0.86112336711986 1 GO:0140358 P-type transmembrane transporter activity 5/5150 25/18639 0.2 0.723844660194175 0.86112336711986 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 21/5150 91/18639 0.230769230769231 0.835205377147125 0.863323850408646 1 GO:0005501 retinoid binding 8/5150 38/18639 0.210526315789474 0.761941747572816 0.863499215191357 1 GO:0019840 isoprenoid binding 8/5150 38/18639 0.210526315789474 0.761941747572816 0.863499215191357 1 GO:0016500 protein-hormone receptor activity 15/5150 67/18639 0.223880597014925 0.810273873351688 0.865094707914814 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 7/5150 34/18639 0.205882352941176 0.745134209023415 0.868678951602131 1 GO:0001846 opsonin binding 4/5150 21/18639 0.19047619047619 0.689375866851595 0.872421787968604 1 GO:0008187 poly-pyrimidine tract binding 6/5150 30/18639 0.2 0.723844660194175 0.87535205234122 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/5150 30/18639 0.2 0.723844660194175 0.87535205234122 1 GO:0098631 cell adhesion mediator activity 17/5150 76/18639 0.223684210526316 0.809563106796117 0.87785031862029 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 5/5150 26/18639 0.192307692307692 0.696004480955937 0.884015254142507 1 GO:0030247 polysaccharide binding 5/5150 26/18639 0.192307692307692 0.696004480955937 0.884015254142507 1 GO:0050681 nuclear androgen receptor binding 5/5150 26/18639 0.192307692307692 0.696004480955937 0.884015254142507 1 GO:0000340 RNA 7-methylguanosine cap binding 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0003720 telomerase activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0004000 adenosine deaminase activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0005247 voltage-gated chloride channel activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0008179 adenylate cyclase binding 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0015166 polyol transmembrane transporter activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0017166 vinculin binding 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0140900 chloride:bicarbonate antiporter activity 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:1990459 transferrin receptor binding 2/5150 12/18639 0.166666666666667 0.603203883495146 0.884882603247795 1 GO:0009881 photoreceptor activity 3/5150 17/18639 0.176470588235294 0.638686464877213 0.888200046590953 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/5150 17/18639 0.176470588235294 0.638686464877213 0.888200046590953 1 GO:0045236 CXCR chemokine receptor binding 3/5150 17/18639 0.176470588235294 0.638686464877213 0.888200046590953 1 GO:1990226 histone methyltransferase binding 3/5150 17/18639 0.176470588235294 0.638686464877213 0.888200046590953 1 GO:0005452 solute:inorganic anion antiporter activity 6/5150 31/18639 0.193548387096774 0.700494832445976 0.894894546638075 1 GO:0017147 Wnt-protein binding 6/5150 31/18639 0.193548387096774 0.700494832445976 0.894894546638075 1 GO:0070325 lipoprotein particle receptor binding 6/5150 31/18639 0.193548387096774 0.700494832445976 0.894894546638075 1 GO:0015377 chloride:monoatomic cation symporter activity 4/5150 22/18639 0.181818181818182 0.658040600176523 0.895402790038046 1 GO:0004177 aminopeptidase activity 8/5150 40/18639 0.2 0.723844660194175 0.89922060519756 1 GO:0008146 sulfotransferase activity 11/5150 53/18639 0.207547169811321 0.751159553031691 0.901933973581505 1 GO:0016860 intramolecular oxidoreductase activity 11/5150 53/18639 0.207547169811321 0.751159553031691 0.901933973581505 1 GO:0005044 scavenger receptor activity 5/5150 27/18639 0.185185185185185 0.670226537216828 0.903591030347179 1 GO:0015373 monoatomic anion:sodium symporter activity 3/5150 18/18639 0.166666666666667 0.603203883495146 0.910637893920994 1 GO:0034185 apolipoprotein binding 3/5150 18/18639 0.166666666666667 0.603203883495146 0.910637893920994 1 GO:0050811 GABA receptor binding 3/5150 18/18639 0.166666666666667 0.603203883495146 0.910637893920994 1 GO:0003964 RNA-directed DNA polymerase activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0005035 death receptor activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0005172 vascular endothelial growth factor receptor binding 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0008417 fucosyltransferase activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0017154 semaphorin receptor activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0030955 potassium ion binding 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0039706 co-receptor binding 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0061459 L-arginine transmembrane transporter activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0071837 HMG box domain binding 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:1901338 catecholamine binding 2/5150 13/18639 0.153846153846154 0.55680358476475 0.911006703406781 1 GO:0008378 galactosyltransferase activity 6/5150 32/18639 0.1875 0.678604368932039 0.911753971119684 1 GO:0043425 bHLH transcription factor binding 6/5150 32/18639 0.1875 0.678604368932039 0.911753971119684 1 GO:0044183 protein folding chaperone 16/5150 75/18639 0.213333333333333 0.772100970873786 0.914735003620855 1 GO:0070001 aspartic-type peptidase activity 7/5150 37/18639 0.189189189189189 0.6847179218053 0.91950682962373 1 GO:0140097 catalytic activity, acting on DNA 82/5150 336/18639 0.244047619047619 0.883262829403606 0.919989942119629 1 GO:0045499 chemorepellent activity 5/5150 28/18639 0.178571428571429 0.64628987517337 0.920218751616311 1 GO:1901681 sulfur compound binding 66/5150 275/18639 0.24 0.86861359223301 0.924415236819495 1 GO:0004620 phospholipase activity 24/5150 109/18639 0.220183486238532 0.796893203883495 0.925134992827009 1 GO:0042379 chemokine receptor binding 15/5150 72/18639 0.208333333333333 0.754004854368932 0.926305535534381 1 GO:0003756 protein disulfide isomerase activity 3/5150 19/18639 0.157894736842105 0.571456310679612 0.928903212609067 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/5150 19/18639 0.157894736842105 0.571456310679612 0.928903212609067 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/5150 19/18639 0.157894736842105 0.571456310679612 0.928903212609067 1 GO:0015245 fatty acid transmembrane transporter activity 3/5150 19/18639 0.157894736842105 0.571456310679612 0.928903212609067 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/5150 19/18639 0.157894736842105 0.571456310679612 0.928903212609067 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/5150 24/18639 0.166666666666667 0.603203883495146 0.930678759936266 1 GO:0005344 oxygen carrier activity 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0008331 high voltage-gated calcium channel activity 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0008494 translation activator activity 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0008559 ABC-type xenobiotic transporter activity 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0031404 chloride ion binding 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/5150 14/18639 0.142857142857143 0.517031900138696 0.931485729522858 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/5150 60/18639 0.2 0.723844660194175 0.93311563695054 1 GO:0106222 lncRNA binding 5/5150 29/18639 0.172413793103448 0.624004017408771 0.934254915374938 1 GO:0001664 G protein-coupled receptor binding 71/5150 297/18639 0.239057239057239 0.865201529861724 0.936471099586803 1 GO:0001217 DNA-binding transcription repressor activity 66/5150 278/18639 0.237410071942446 0.859240064259272 0.938601816646365 1 GO:0038024 cargo receptor activity 13/5150 65/18639 0.2 0.723844660194175 0.939469247502942 1 GO:0003678 DNA helicase activity 15/5150 74/18639 0.202702702702703 0.733626344791393 0.943181966756482 1 GO:0001972 retinoic acid binding 3/5150 20/18639 0.15 0.542883495145631 0.943674439420856 1 GO:0005326 neurotransmitter transmembrane transporter activity 3/5150 20/18639 0.15 0.542883495145631 0.943674439420856 1 GO:0005251 delayed rectifier potassium channel activity 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0015271 outward rectifier potassium channel activity 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0120020 cholesterol transfer activity 4/5150 25/18639 0.16 0.57907572815534 0.94392740618701 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 63/5150 268/18639 0.235074626865672 0.850787567019273 0.945864839914026 1 GO:0016758 hexosyltransferase activity 45/5150 197/18639 0.228426395939086 0.82672613473954 0.946422065571812 1 GO:0000774 adenyl-nucleotide exchange factor activity 2/5150 15/18639 0.133333333333333 0.482563106796116 0.947444187713995 1 GO:0015929 hexosaminidase activity 2/5150 15/18639 0.133333333333333 0.482563106796116 0.947444187713995 1 GO:0031005 filamin binding 2/5150 15/18639 0.133333333333333 0.482563106796116 0.947444187713995 1 GO:0048531 beta-1,3-galactosyltransferase activity 2/5150 15/18639 0.133333333333333 0.482563106796116 0.947444187713995 1 GO:0008194 UDP-glycosyltransferase activity 32/5150 145/18639 0.220689655172414 0.798725142283227 0.947515638688123 1 GO:0060590 ATPase regulator activity 9/5150 49/18639 0.183673469387755 0.664755300178324 0.951671964079348 1 GO:0140662 ATP-dependent protein folding chaperone 7/5150 40/18639 0.175 0.633364077669903 0.952310173907462 1 GO:0016298 lipase activity 28/5150 130/18639 0.215384615384615 0.77952501867065 0.954177594555525 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/5150 26/18639 0.153846153846154 0.55680358476475 0.954820524740556 1 GO:0005123 death receptor binding 3/5150 21/18639 0.142857142857143 0.517031900138696 0.955549881329564 1 GO:0015125 bile acid transmembrane transporter activity 3/5150 21/18639 0.142857142857143 0.517031900138696 0.955549881329564 1 GO:0036122 BMP binding 3/5150 21/18639 0.142857142857143 0.517031900138696 0.955549881329564 1 GO:0046915 transition metal ion transmembrane transporter activity 8/5150 45/18639 0.177777777777778 0.643417475728155 0.955706849364092 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/5150 31/18639 0.161290322580645 0.58374569370498 0.955870284393913 1 GO:0008327 methyl-CpG binding 5/5150 31/18639 0.161290322580645 0.58374569370498 0.955870284393913 1 GO:0005126 cytokine receptor binding 64/5150 275/18639 0.232727272727273 0.842291968225949 0.956969003023173 1 GO:0004222 metalloendopeptidase activity 23/5150 110/18639 0.209090909090909 0.756746690203001 0.957539240042562 1 GO:0004190 aspartic-type endopeptidase activity 6/5150 36/18639 0.166666666666667 0.603203883495146 0.957824762380323 1 GO:0005149 interleukin-1 receptor binding 2/5150 16/18639 0.125 0.452402912621359 0.959816252709839 1 GO:0001530 lipopolysaccharide binding 7/5150 41/18639 0.170731707317073 0.617916173336491 0.960217956197976 1 GO:0001618 virus receptor activity 16/5150 81/18639 0.197530864197531 0.714908306364617 0.960575633256074 1 GO:0003796 lysozyme activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0005031 tumor necrosis factor receptor activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0008190 eukaryotic initiation factor 4E binding 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0008239 dipeptidyl-peptidase activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0019531 oxalate transmembrane transporter activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0031720 haptoglobin binding 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0032395 MHC class II receptor activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0042166 acetylcholine binding 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/5150 10/18639 0.1 0.361922330097087 0.960629494908962 1 GO:0046906 tetrapyrrole binding 33/5150 152/18639 0.217105263157895 0.785752427184466 0.960870706852169 1 GO:0042562 hormone binding 19/5150 94/18639 0.202127659574468 0.731545135302623 0.961568813857688 1 GO:0005104 fibroblast growth factor receptor binding 4/5150 27/18639 0.148148148148148 0.536181229773463 0.963730002026361 1 GO:0005385 zinc ion transmembrane transporter activity 4/5150 27/18639 0.148148148148148 0.536181229773463 0.963730002026361 1 GO:0023026 MHC class II protein complex binding 4/5150 27/18639 0.148148148148148 0.536181229773463 0.963730002026361 1 GO:0035255 ionotropic glutamate receptor binding 4/5150 27/18639 0.148148148148148 0.536181229773463 0.963730002026361 1 GO:0042910 xenobiotic transmembrane transporter activity 5/5150 32/18639 0.15625 0.565503640776699 0.964039972037289 1 GO:0071813 lipoprotein particle binding 5/5150 32/18639 0.15625 0.565503640776699 0.964039972037289 1 GO:0071814 protein-lipid complex binding 5/5150 32/18639 0.15625 0.565503640776699 0.964039972037289 1 GO:0022829 wide pore channel activity 6/5150 37/18639 0.162162162162162 0.586901075833115 0.965241136462244 1 GO:0140272 exogenous protein binding 16/5150 82/18639 0.195121951219512 0.706189912384561 0.965610121679732 1 GO:0015291 secondary active transmembrane transporter activity 66/5150 287/18639 0.229965156794425 0.832295253881804 0.968643546498147 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/5150 17/18639 0.117647058823529 0.425790976584809 0.969365080192357 1 GO:0016018 cyclosporin A binding 2/5150 17/18639 0.117647058823529 0.425790976584809 0.969365080192357 1 GO:0019198 transmembrane receptor protein phosphatase activity 2/5150 17/18639 0.117647058823529 0.425790976584809 0.969365080192357 1 GO:0038191 neuropilin binding 2/5150 17/18639 0.117647058823529 0.425790976584809 0.969365080192357 1 GO:0020037 heme binding 30/5150 142/18639 0.211267605633803 0.764624641050185 0.969430516138865 1 GO:0005109 frizzled binding 6/5150 38/18639 0.157894736842105 0.571456310679612 0.971445028867289 1 GO:0001851 complement component C3b binding 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0008172 S-methyltransferase activity 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0008503 benzodiazepine receptor activity 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0016594 glycine binding 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/5150 11/18639 0.0909090909090909 0.329020300088261 0.971513498409893 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/5150 23/18639 0.130434782608696 0.472072604474462 0.97260524258886 1 GO:0016493 C-C chemokine receptor activity 3/5150 23/18639 0.130434782608696 0.472072604474462 0.97260524258886 1 GO:0140103 catalytic activity, acting on a glycoprotein 3/5150 23/18639 0.130434782608696 0.472072604474462 0.97260524258886 1 GO:0015179 L-amino acid transmembrane transporter activity 11/5150 62/18639 0.17741935483871 0.642120263075478 0.97480924719671 1 GO:0017046 peptide hormone binding 9/5150 53/18639 0.169811320754717 0.614585088844111 0.975496680169394 1 GO:0051427 hormone receptor binding 5/5150 34/18639 0.147058823529412 0.532238720731011 0.97635628433824 1 GO:0004970 glutamate-gated receptor activity 2/5150 18/18639 0.111111111111111 0.402135922330097 0.976705978476278 1 GO:0015280 ligand-gated sodium channel activity 2/5150 18/18639 0.111111111111111 0.402135922330097 0.976705978476278 1 GO:0099602 neurotransmitter receptor regulator activity 2/5150 18/18639 0.111111111111111 0.402135922330097 0.976705978476278 1 GO:0004629 phospholipase C activity 4/5150 29/18639 0.137931034482759 0.499203213927017 0.976858190969865 1 GO:0042626 ATPase-coupled transmembrane transporter activity 19/5150 98/18639 0.193877551020408 0.701686150188231 0.977257924293887 1 GO:0019957 C-C chemokine binding 3/5150 24/18639 0.125 0.452402912621359 0.978594740110659 1 GO:0030215 semaphorin receptor binding 3/5150 24/18639 0.125 0.452402912621359 0.978594740110659 1 GO:0005253 monoatomic anion channel activity 20/5150 103/18639 0.194174757281553 0.702761806013762 0.979240647129474 1 GO:0005436 sodium:phosphate symporter activity 1/5150 12/18639 0.0833333333333333 0.301601941747573 0.97938903433372 1 GO:0036002 pre-mRNA binding 10/5150 59/18639 0.169491525423729 0.613427678130657 0.980677659659654 1 GO:0008009 chemokine activity 7/5150 45/18639 0.155555555555556 0.562990291262136 0.981315332988302 1 GO:0048020 CCR chemokine receptor binding 8/5150 50/18639 0.16 0.57907572815534 0.981995016460319 1 GO:0016887 ATP hydrolysis activity 97/5150 417/18639 0.232613908872902 0.841881679122721 0.982224676180621 1 GO:0008574 plus-end-directed microtubule motor activity 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0022840 leak channel activity 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0022842 narrow pore channel activity 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0031420 alkali metal ion binding 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0043395 heparan sulfate proteoglycan binding 2/5150 19/18639 0.105263157894737 0.380970873786408 0.982329833284185 1 GO:0001848 complement binding 3/5150 25/18639 0.12 0.434306796116505 0.98332210382752 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 38/5150 181/18639 0.209944751381215 0.759836936115432 0.983746651883528 1 GO:0004993 G protein-coupled serotonin receptor activity 1/5150 13/18639 0.0769230769230769 0.278401792382375 0.985087561910965 1 GO:0008035 high-density lipoprotein particle binding 1/5150 13/18639 0.0769230769230769 0.278401792382375 0.985087561910965 1 GO:0035673 oligopeptide transmembrane transporter activity 1/5150 13/18639 0.0769230769230769 0.278401792382375 0.985087561910965 1 GO:0097157 pre-mRNA intronic binding 1/5150 13/18639 0.0769230769230769 0.278401792382375 0.985087561910965 1 GO:0170055 lipid transmembrane transporter activity 9/5150 56/18639 0.160714285714286 0.581660887656033 0.985686103155955 1 GO:0140939 histone H4 methyltransferase activity 2/5150 20/18639 0.1 0.361922330097087 0.986624877046777 1 GO:0001637 G protein-coupled chemoattractant receptor activity 3/5150 26/18639 0.115384615384615 0.417602688573562 0.987039701099733 1 GO:0004950 chemokine receptor activity 3/5150 26/18639 0.115384615384615 0.417602688573562 0.987039701099733 1 GO:0008143 poly(A) binding 3/5150 26/18639 0.115384615384615 0.417602688573562 0.987039701099733 1 GO:0099095 ligand-gated monoatomic anion channel activity 7/5150 47/18639 0.148936170212766 0.539033257591407 0.987406501182794 1 GO:0005506 iron ion binding 31/5150 154/18639 0.201298701298701 0.728544950195436 0.987472274707956 1 GO:0030280 structural constituent of skin epidermis 5/5150 37/18639 0.135135135135135 0.489084229860929 0.987671613919705 1 GO:0140597 protein carrier chaperone 39/5150 188/18639 0.207446808510638 0.750796323073745 0.988045767134393 1 GO:0061135 endopeptidase regulator activity 38/5150 184/18639 0.206521739130435 0.747448290417898 0.988270732149128 1 GO:0015106 bicarbonate transmembrane transporter activity 4/5150 32/18639 0.125 0.452402912621359 0.988465120014664 1 GO:0070717 poly-purine tract binding 4/5150 32/18639 0.125 0.452402912621359 0.988465120014664 1 GO:0042813 Wnt receptor activity 1/5150 14/18639 0.0714285714285714 0.258515950069348 0.989210779786973 1 GO:0043176 amine binding 1/5150 14/18639 0.0714285714285714 0.258515950069348 0.989210779786973 1 GO:0061783 peptidoglycan muralytic activity 1/5150 14/18639 0.0714285714285714 0.258515950069348 0.989210779786973 1 GO:0015174 basic amino acid transmembrane transporter activity 2/5150 21/18639 0.0952380952380952 0.344687933425798 0.989895929227537 1 GO:0051428 peptide hormone receptor binding 2/5150 21/18639 0.0952380952380952 0.344687933425798 0.989895929227537 1 GO:1901682 sulfur compound transmembrane transporter activity 10/5150 63/18639 0.158730158730159 0.574479889042996 0.990492208740686 1 GO:0008020 G protein-coupled photoreceptor activity 1/5150 15/18639 0.0666666666666667 0.241281553398058 0.992194107792186 1 GO:0015116 sulfate transmembrane transporter activity 1/5150 15/18639 0.0666666666666667 0.241281553398058 0.992194107792186 1 GO:0015250 water channel activity 1/5150 15/18639 0.0666666666666667 0.241281553398058 0.992194107792186 1 GO:0140161 monocarboxylate:sodium symporter activity 1/5150 15/18639 0.0666666666666667 0.241281553398058 0.992194107792186 1 GO:0008527 taste receptor activity 3/5150 28/18639 0.107142857142857 0.387773925104022 0.992229997850609 1 GO:0015020 glucuronosyltransferase activity 4/5150 34/18639 0.117647058823529 0.425790976584809 0.992841848642415 1 GO:0019825 oxygen binding 4/5150 34/18639 0.117647058823529 0.425790976584809 0.992841848642415 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 11/5150 70/18639 0.157142857142857 0.568735090152566 0.993654846401581 1 GO:0015144 carbohydrate transmembrane transporter activity 5/5150 40/18639 0.125 0.452402912621359 0.993720230923191 1 GO:0005416 amino acid:monoatomic cation symporter activity 3/5150 29/18639 0.103448275862069 0.374402410445263 0.99400366787531 1 GO:0005212 structural constituent of eye lens 2/5150 23/18639 0.0869565217391304 0.314715069649641 0.994264233627285 1 GO:0005283 amino acid:sodium symporter activity 2/5150 23/18639 0.0869565217391304 0.314715069649641 0.994264233627285 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/5150 16/18639 0.0625 0.22620145631068 0.994352631464342 1 GO:0022841 potassium ion leak channel activity 1/5150 16/18639 0.0625 0.22620145631068 0.994352631464342 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/5150 16/18639 0.0625 0.22620145631068 0.994352631464342 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/5150 16/18639 0.0625 0.22620145631068 0.994352631464342 1 GO:0005272 sodium channel activity 7/5150 51/18639 0.137254901960784 0.496756139348943 0.994444298659821 1 GO:0048019 receptor antagonist activity 3/5150 30/18639 0.1 0.361922330097087 0.99538183705304 1 GO:0008509 monoatomic anion transmembrane transporter activity 28/5150 149/18639 0.187919463087248 0.680122499511305 0.995385431108107 1 GO:0015149 hexose transmembrane transporter activity 2/5150 24/18639 0.0833333333333333 0.301601941747573 0.995688733037887 1 GO:0055056 D-glucose transmembrane transporter activity 2/5150 24/18639 0.0833333333333333 0.301601941747573 0.995688733037887 1 GO:0140359 ABC-type transporter activity 6/5150 47/18639 0.127659574468085 0.46202850650692 0.995696848633644 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/5150 17/18639 0.0588235294117647 0.212895488292404 0.995914353418842 1 GO:0030548 acetylcholine receptor regulator activity 1/5150 17/18639 0.0588235294117647 0.212895488292404 0.995914353418842 1 GO:0042056 chemoattractant activity 5/5150 42/18639 0.119047619047619 0.430859916782247 0.996040308377085 1 GO:0042277 peptide binding 51/5150 249/18639 0.204819277108434 0.741286700198854 0.996342809068706 1 GO:0005184 neuropeptide hormone activity 3/5150 31/18639 0.0967741935483871 0.350247416222988 0.996450036396134 1 GO:0005244 voltage-gated monoatomic ion channel activity 33/5150 173/18639 0.190751445086705 0.69037207475167 0.996566016758832 1 GO:0005261 monoatomic cation channel activity 73/5150 341/18639 0.214076246334311 0.774789738917518 0.996696144577188 1 GO:0030414 peptidase inhibitor activity 32/5150 169/18639 0.189349112426035 0.685296719710461 0.99671498168242 1 GO:0005372 water transmembrane transporter activity 1/5150 18/18639 0.0555555555555556 0.201067961165049 0.997044257827228 1 GO:0030228 lipoprotein particle receptor activity 1/5150 18/18639 0.0555555555555556 0.201067961165049 0.997044257827228 1 GO:0160041 neuropeptide activity 3/5150 32/18639 0.09375 0.339302184466019 0.9972760622287 1 GO:0042887 amide transmembrane transporter activity 4/5150 38/18639 0.105263157894737 0.380970873786408 0.997315308162602 1 GO:0022832 voltage-gated channel activity 33/5150 175/18639 0.188571428571429 0.682482108183079 0.997352835728321 1 GO:0030547 signaling receptor inhibitor activity 5/5150 44/18639 0.113636363636364 0.411275375110327 0.997523753300604 1 GO:0008066 glutamate receptor activity 2/5150 26/18639 0.0769230769230769 0.278401792382375 0.997574458016319 1 GO:0015145 monosaccharide transmembrane transporter activity 2/5150 26/18639 0.0769230769230769 0.278401792382375 0.997574458016319 1 GO:0099094 ligand-gated monoatomic cation channel activity 24/5150 136/18639 0.176470588235294 0.638686464877213 0.997628353688319 1 GO:0008201 heparin binding 32/5150 172/18639 0.186046511627907 0.67334386994807 0.997792971247703 1 GO:0004867 serine-type endopeptidase inhibitor activity 15/5150 95/18639 0.157894736842105 0.571456310679612 0.997794443924627 1 GO:0008301 DNA binding, bending 1/5150 19/18639 0.0526315789473684 0.190485436893204 0.997861725857397 1 GO:0034987 immunoglobulin receptor binding 1/5150 19/18639 0.0526315789473684 0.190485436893204 0.997861725857397 1 GO:0099589 serotonin receptor activity 1/5150 19/18639 0.0526315789473684 0.190485436893204 0.997861725857397 1 GO:0015293 symporter activity 26/5150 146/18639 0.178082191780822 0.644519217981114 0.997959959297588 1 GO:0004386 helicase activity 28/5150 155/18639 0.180645161290323 0.653795176949577 0.997982986379133 1 GO:0015079 potassium ion transmembrane transporter activity 29/5150 160/18639 0.18125 0.655984223300971 0.998135871031835 1 GO:0008395 steroid hydroxylase activity 2/5150 27/18639 0.0740740740740741 0.268090614886731 0.998184141578912 1 GO:0004866 endopeptidase inhibitor activity 29/5150 161/18639 0.180124223602484 0.6519097871314 0.998381268032505 1 GO:0090482 vitamin transmembrane transporter activity 3/5150 34/18639 0.0882352941176471 0.319343232438607 0.99840422973431 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/5150 20/18639 0.05 0.180961165048544 0.998453138952692 1 GO:0015464 acetylcholine receptor activity 1/5150 20/18639 0.05 0.180961165048544 0.998453138952692 1 GO:0030627 pre-mRNA 5'-splice site binding 1/5150 20/18639 0.05 0.180961165048544 0.998453138952692 1 GO:0061775 cohesin loader activity 27/5150 153/18639 0.176470588235294 0.638686464877213 0.998586575213069 1 GO:0005254 chloride channel activity 12/5150 83/18639 0.144578313253012 0.523261200140367 0.998602773674938 1 GO:0005242 inward rectifier potassium channel activity 2/5150 28/18639 0.0714285714285714 0.258515950069348 0.998642152634935 1 GO:0051119 sugar transmembrane transporter activity 2/5150 28/18639 0.0714285714285714 0.258515950069348 0.998642152634935 1 GO:0005343 organic acid:sodium symporter activity 3/5150 35/18639 0.0857142857142857 0.310219140083218 0.998781439446424 1 GO:0005539 glycosaminoglycan binding 47/5150 242/18639 0.194214876033058 0.702907004734013 0.998835843364601 1 GO:0005248 voltage-gated sodium channel activity 1/5150 21/18639 0.0476190476190476 0.172343966712899 0.99888099943895 1 GO:0015081 sodium ion transmembrane transporter activity 29/5150 164/18639 0.176829268292683 0.639984608098508 0.998947425149973 1 GO:0140713 histone chaperone activity 29/5150 164/18639 0.176829268292683 0.639984608098508 0.998947425149973 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/5150 36/18639 0.0833333333333333 0.301601941747573 0.999070826362821 1 GO:0005267 potassium channel activity 20/5150 124/18639 0.161290322580645 0.58374569370498 0.999123815056305 1 GO:0008094 ATP-dependent activity, acting on DNA 39/5150 210/18639 0.185714285714286 0.672141470180305 0.999169035839296 1 GO:0022843 voltage-gated monoatomic cation channel activity 24/5150 143/18639 0.167832167832168 0.607422092470636 0.999184653163968 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 104/5150 484/18639 0.214876033057851 0.777684345663163 0.999279805471323 1 GO:0015171 amino acid transmembrane transporter activity 15/5150 102/18639 0.147058823529412 0.532238720731011 0.999370900096573 1 GO:0001216 DNA-binding transcription activator activity 105/5150 491/18639 0.213849287169043 0.773968323018211 0.999450295185981 1 GO:0004175 endopeptidase activity 84/5150 405/18639 0.207407407407407 0.750653721682848 0.999475826617007 1 GO:0003689 DNA clamp loader activity 27/5150 160/18639 0.16875 0.610743932038835 0.999507165477295 1 GO:0000510 H3-H4 histone complex chaperone activity 25/5150 151/18639 0.165562913907285 0.59920915578988 0.99952249292152 1 GO:0140584 chromatin extrusion motor activity 25/5150 151/18639 0.165562913907285 0.59920915578988 0.99952249292152 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 25/5150 151/18639 0.165562913907285 0.59920915578988 0.99952249292152 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 25/5150 151/18639 0.165562913907285 0.59920915578988 0.99952249292152 1 GO:0015103 inorganic anion transmembrane transporter activity 28/5150 165/18639 0.16969696969697 0.614171226831421 0.999538379755306 1 GO:0015616 DNA translocase activity 25/5150 152/18639 0.164473684210526 0.595266990291262 0.999592793631855 1 GO:0140674 ATP-dependent histone chaperone activity 25/5150 152/18639 0.164473684210526 0.595266990291262 0.999592793631855 1 GO:0017171 serine hydrolase activity 35/5150 198/18639 0.176767676767677 0.639761694616064 0.99962185817137 1 GO:0046873 metal ion transmembrane transporter activity 94/5150 450/18639 0.208888888888889 0.756015533980583 0.999634331363413 1 GO:0008083 growth factor activity 27/5150 162/18639 0.166666666666667 0.603203883495146 0.999638937601601 1 GO:0008236 serine-type peptidase activity 34/5150 194/18639 0.175257731958763 0.634296867180462 0.999647576933061 1 GO:0004252 serine-type endopeptidase activity 30/5150 176/18639 0.170454545454545 0.61691306266549 0.999653034614623 1 GO:0140658 ATP-dependent chromatin remodeler activity 26/5150 158/18639 0.164556962025316 0.595568391299005 0.999672554612892 1 GO:0042923 neuropeptide binding 2/5150 33/18639 0.0606060606060606 0.219346866725508 0.999687284114104 1 GO:0071855 neuropeptide receptor binding 3/5150 40/18639 0.075 0.271441747572816 0.99968995792287 1 GO:0004497 monooxygenase activity 15/5150 106/18639 0.141509433962264 0.512154240703426 0.999702212775458 1 GO:0015108 chloride transmembrane transporter activity 18/5150 121/18639 0.148760330578512 0.538396854689882 0.999717009543863 1 GO:0008188 neuropeptide receptor activity 4/5150 48/18639 0.0833333333333333 0.301601941747573 0.999794903716543 1 GO:0003724 RNA helicase activity 9/5150 77/18639 0.116883116883117 0.423026100113479 0.99980119022944 1 GO:0005249 voltage-gated potassium channel activity 13/5150 98/18639 0.13265306122449 0.480101050128789 0.999801230869748 1 GO:0008186 ATP-dependent activity, acting on RNA 9/5150 79/18639 0.113924050632911 0.412316578591619 0.99987247510495 1 GO:0015370 solute:sodium symporter activity 9/5150 79/18639 0.113924050632911 0.412316578591619 0.99987247510495 1 GO:0015294 solute:monoatomic cation symporter activity 16/5150 116/18639 0.137931034482759 0.499203213927017 0.999885537034459 1 GO:0046943 carboxylic acid transmembrane transporter activity 31/5150 188/18639 0.164893617021277 0.596786820904772 0.999889446163798 1 GO:0005342 organic acid transmembrane transporter activity 31/5150 189/18639 0.164021164021164 0.593629218677762 0.999905560041219 1 GO:0005216 monoatomic ion channel activity 90/5150 448/18639 0.200892857142857 0.727076109570042 0.999921220185621 1 GO:0008514 organic anion transmembrane transporter activity 48/5150 269/18639 0.178438661710037 0.645809362255026 0.999938955962111 1 GO:0008227 G protein-coupled amine receptor activity 2/5150 41/18639 0.0487804878048781 0.17654747809614 0.999971341491132 1 GO:0015276 ligand-gated monoatomic ion channel activity 28/5150 186/18639 0.150537634408602 0.544829314124648 0.99998511500706 1 GO:0008528 G protein-coupled peptide receptor activity 15/5150 122/18639 0.122950819672131 0.444986471430845 0.99998767355723 1 GO:0022834 ligand-gated channel activity 28/5150 188/18639 0.148936170212766 0.539033257591407 0.999989492035617 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/5150 53/18639 0.0566037735849057 0.20486169628137 0.999992167995266 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/5150 46/18639 0.0434782608695652 0.157357534824821 0.999993684433829 1 GO:0001653 peptide receptor activity 15/5150 128/18639 0.1171875 0.424127730582524 0.999996514507681 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/5150 56/18639 0.0535714285714286 0.193886962552011 0.999996710024746 1 GO:0022836 gated channel activity 54/5150 318/18639 0.169811320754717 0.614585088844111 0.999997397874929 1 GO:0042605 peptide antigen binding 1/5150 45/18639 0.0222222222222222 0.0804271844660194 0.999999530918906 1 GO:0022824 transmitter-gated monoatomic ion channel activity 3/5150 63/18639 0.0476190476190476 0.172343966712899 0.999999574015201 1 GO:0022835 transmitter-gated channel activity 3/5150 63/18639 0.0476190476190476 0.172343966712899 0.999999574015201 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/5150 73/18639 0.0547945205479452 0.198313605532651 0.999999791702221 1 GO:0005125 cytokine activity 32/5150 234/18639 0.136752136752137 0.494936519790889 0.999999911465968 1 GO:0098960 postsynaptic neurotransmitter receptor activity 3/5150 69/18639 0.0434782608695652 0.157357534824821 0.999999927553633 1 GO:0005179 hormone activity 12/5150 132/18639 0.0909090909090909 0.329020300088261 0.999999970074557 1 GO:0030594 neurotransmitter receptor activity 5/5150 97/18639 0.0515463917525773 0.186557902111901 0.999999998165532 1 GO:0003730 mRNA 3'-UTR binding 29/5150 262/18639 0.110687022900763 0.400601052397539 0.999999999986933 1 GO:0003823 antigen binding 8/5150 174/18639 0.0459770114942529 0.166401071309006 1 1 GO:0030371 translation repressor activity 9/5150 329/18639 0.027355623100304 0.0990061085371972 1 1 GO:0045182 translation regulator activity 18/5150 356/18639 0.050561797752809 0.182994436565943 1 1