category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	99/1391	222/9376	3.00588726756951	RPS29/RPL39/RPL34/RPL37/RPL27A/RPS11/RPS7/RPS21/RPL30/RPL38/RPL37A/RPS4X/RPS28/RPLP2/RPL12/RPL10/RPS23/RPS27/RPL35A/RPL36/RPL23/RPS27A/RPL28/RPL7/RPS14/RPL32/RPS24/RPLP0/RPS15A/RPL6/RPS13/MRPL33/RPL24/UBA52/MRPL20/FAU/RPS16/RPS3A/RPS20/RPLP1/RPL11/RPL5/RPL21/RPL14/MRPS21/RPL13/RPL41/RPS8/RPL31/RPL13A/RPL23A/RPL3/RPS12/MRPL13/MRPL51/RPL22L1/MRPL47/RPL26L1/MRPL43/RPS3/MRPS33/RPL9/RPL19/RPL29/MRPL11/MRPL22/RPL10A/RSL24D1/RPS5/RPS6/MRPL52/RPL27/RACK1/MRPL16/MRPS10/MRPL40/RPS19/RPL18/MRPL21/MRPL19/RPL15/MRPL36/MRPS6/MRPS18C/MRPL15/MRPS23/MRPL28/MRPL27/MRPL32/MRPS34/MRPS31/MRPS22/MRPS16/MRPL24/MRPL18/MRPL17/MRPL1/MRPL3/MRPS18A	12.6237765271394
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	62/1391	138/9376	3.02832911366028	UQCRB/NDUFA4/COX6C/ATP5F1E/ATP5ME/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/COX17/NDUFB11/COX6B1/NDUFA2/COX6A1/NDUFA12/ATP5F1D/UQCRQ/NDUFV2/NDUFB7/COX7A1/NDUFB3/NDUFB6/NDUFC2/NDUFB5/NDUFB4/NDUFS5/ATP5MF/SDHD/NDUFB10/ATP5MC2/COX8A/ATP5PO/COX7A2L/MT-ND3/ATP6V1G1/UQCRH/NDUFA4L2/ATP5PD/COX4I1/COX5A/ATP5PB/ATP6V1D/NDUFB2/COX7C/NDUFS8/ATP5MC1/NDUFA8/NDUFA5/ATP5F1A/NDUFC1/UQCR11/COX5B/NDUFB9/NDUFS6/TCIRG1/ATP6V1F	10.0184545330711
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	93/1391	268/9376	2.3390452482376	UQCRB/NDUFA4/COX6C/ATP5F1E/MAP3K5/COX7A2/RPS27A/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/UBB/PARK7/COX7B/UBA52/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/TXN/COX6A1/NDUFA12/ATP5F1D/GNAI1/UQCRQ/NDUFV2/NDUFB7/COX7A1/VDAC3/NDUFB3/PSMB7/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/CALM1/NDUFS5/SDHD/NDUFB10/ATP5MC2/COX8A/ATP5PO/COX7A2L/MT-ND3/PSMB1/SOD1/UQCRH/NDUFA4L2/PRKN/ATP5PD/SLC39A13/PSMA1/COX4I1/SLC39A4/COX5A/ATP5PB/PSMA5/NDUFB2/MAPK8/PSMB4/VDAC2/PSMA3/PSMA4/COX7C/NDUFS8/ATP5MC1/CAMK2D/PSMB5/NDUFA8/GNAI2/TUBB6/NDUFA5/EIF2AK3/ATP5F1A/NDUFC1/UQCR11/PRKACB/GNAS/COX5B/PSMD8/NDUFB9/MAPK10/NDUFS6/UBE2J1/HTRA2/MCU/MAOB	9.28245562371214
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	94/1391	275/9376	2.30401673093262	C7/UQCRB/NDUFA4/NCAM2/COX6C/ATP5F1E/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/C6/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/COX6A1/RYR2/NDUFA12/ATP5F1D/UQCRQ/NDUFV2/NDUFB7/COX7A1/VDAC3/NDUFB3/PSMB7/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/NDUFS5/BAD/SDHD/NDUFB10/ATP5MC2/CYBA/IL1B/COX8A/ATP5PO/COX7A2L/MT-ND3/PSMB1/SOD1/UQCRH/NDUFA4L2/ATP5PD/PSMA1/COX4I1/COX5A/CAV2/ATP5PB/PSMA5/NDUFB2/MAPK8/PPP3CA/PSMB4/VDAC2/PSMA3/PSMA4/PPP3CC/COX7C/NDUFS8/ATP5MC1/PSMB5/NDUFA8/TUBB6/NDUFA5/EIF2AK3/RAC2/ATP5F1A/CAV1/NDUFC1/UQCR11/PRKACB/COX5B/NCAM1/CSNK2A1/PSMD8/NDUFB9/MAPK10/NDUFS6/PRNP/FYN/PIK3R1/MCU/CREB5	9.1604476308891
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	77/1391	205/9376	2.53178797496099	CD36/UQCRB/NDUFA4/PLCB1/COX6C/ATP5F1E/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/COX6B1/NDUFA2/PPP1CA/COX6A1/RYR2/NDUFA12/PDHB/ATP5F1D/UQCRQ/NDUFV2/NDUFB7/COX7A1/VDAC3/NDUFB3/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/NDUFS5/SDHD/NDUFB10/ATP5MC2/CYBA/COX8A/ATP5PO/COX7A2L/MT-ND3/UQCRH/NDUFA4L2/ATP5PD/TGFB3/COX4I1/COX5A/ATP5PB/NDUFB2/MAPK8/MPC1/VDAC2/COX7C/NDUFS8/ATP5MC1/CAMK2D/NDUFA8/NDUFA5/RAC2/ATP5F1A/PRKCG/NDUFC1/UQCR11/PRKCA/PLCB4/COX5B/NDUFB9/MAPK10/NDUFS6/TNNI3/PIK3R1/ATP2A3/PARP1	9.2550545446538
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	98/1391	308/9376	2.14469642507026	UQCRB/NDUFA4/PLCB1/COX6C/ATP5F1E/MAP3K5/COX7A2/POLR2L/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/GPX7/COX6A1/NDUFA12/ATP5F1D/UQCRQ/POLR2G/NDUFV2/DCTN3/NDUFB7/COX7A1/VDAC3/NDUFB3/PSMB7/NDUFB6/POLR2K/NDUFC2/NDUFB5/VDAC1/NDUFB4/NDUFS5/SDHD/NDUFB10/ATP5MC2/COX8A/ATP5PO/COX7A2L/MT-ND3/AP2S1/POLR2J/PSMB1/SOD1/UQCRH/NDUFA4L2/ATP5PD/PSMA1/COX4I1/COX5A/GPX8/ATP5PB/PSMA5/NDUFB2/MAPK8/PSMB4/VDAC2/PSMA3/PSMA4/AMBRA1/COX7C/NDUFS8/ATP5MC1/PSMB5/NDUFA8/TUBB6/WIPI1/NDUFA5/POLR2I/ACTR10/ATP5F1A/RCOR1/HIP1/CASP8/NDUFC1/GPX1/UQCR11/PLCB4/COX5B/PSMD8/NDUFB9/MAPK10/NDUFS6/DCTN2/POLR2F/NRF1/CLTCL1/CREB5/DCTN6	8.52553559542862
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	79/1391	227/9376	2.34580389350038	UQCRB/NDUFA4/COX6C/ATP5F1E/MAP3K5/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/COX6B1/NDUFA2/COX6A1/NDUFA12/ATP5F1D/UQCRQ/NDUFV2/PRKD1/NDUFB7/COX7A1/VDAC3/NDUFB3/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/NDUFS5/BAD/SDHD/NDUFB10/ATP5MC2/CYBA/COX8A/ATP5PO/COX7A2L/MT-ND3/MGST1/SOD1/UQCRH/NDUFA4L2/PTK2/ATP5PD/COX4I1/COX5A/ATP5PB/NDUFB2/MAPK8/GSTT1/VDAC2/SOS1/AKR1A1/COX7C/NDUFS8/ATP5MC1/NDUFA8/GSTA4/NDUFA5/ATP5F1A/MGST2/NDUFC1/UQCR11/COX5B/ACP1/NDUFB9/MAPK10/NDUFS6/MAP2K4/PIK3R1/NQO1/EPHX2/CAT/FOXO3	8.56681992628052
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	80/1391	238/9376	2.26570570715705	C7/RPS29/RPL39/RPL34/RPL37/RPL27A/NRP1/RPS11/RPS7/RPS21/RPL30/RPL38/RPL37A/RPS4X/RPS28/RPLP2/RPL12/RPL10/RPS23/RPS27/RPL35A/RPL36/RPL23/RPS27A/RPL28/RPL7/RPS14/RPL32/RPS24/RPLP0/RPS15A/RPL6/RPS13/RPL24/UBA52/C6/FAU/RPS16/RPS3A/RPS20/RPLP1/RPL11/RPL5/RPL21/RPL14/RPL13/RPL41/RPS8/RPL31/RPL13A/RPL23A/RPL3/RPS12/IL1B/RPL22L1/RPL26L1/RPS3/JAK1/RPL9/RPL19/RPL29/RPL10A/RSL24D1/RPS5/MAPK8/RPS6/MMP1/RPL27/RPS19/RPL18/PRKCG/RPL15/C1S/PRKCA/MAPK10/VWF/STAT2/PIK3R1/TRAF3/STAT1	8.25481572863102
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	77/1391	235/9376	2.20858099943405	UQCRB/NDUFA4/COX6C/ATP5F1E/PRKG1/MAP3K5/ATP5ME/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/COX17/NDUFB11/COX6B1/NDUFA2/COX6A1/NDUFA12/ATP5F1D/UQCRQ/NDUFV2/NDUFB7/COX7A1/NDUFB3/NDUFB6/NDUFC2/NDUFB5/NDUFB4/NDUFS5/ATP5MF/SDHD/NDUFB10/ATP5MC2/COX8A/ATP5PO/COX7A2L/MT-ND3/UQCRH/NDUFA4L2/ATP5PD/COX4I1/COX5A/COA1/ATP5PB/NDUFB2/RPS6/SOS1/NDUFAF2/COX7C/NDUFS8/ATP5MC1/NDUFA8/ADCY3/NDUFA5/ATP5F1A/COA5/NDUFC1/UQCR11/ACTG1/NDUFAF8/PRKACB/GNAS/COX5B/NDUFB9/NDUFS6/COA3/NDUFAF5/NDUFAF4/COX14/COA6/SMARCD3/CREB5	7.83113267563129
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	124/1391	480/9376	1.74128924035466	WNT11/UQCRB/NDUFA4/PLCB1/COX6C/ATP5F1E/MAP3K5/COX7A2/RPS27A/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/UBB/PARK7/COX7B/UBA52/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/GPX7/COX6A1/RYR2/CCS/NDUFA12/DKK1/ATP5F1D/UQCRQ/NDUFV2/DCTN3/NDUFB7/COX7A1/VDAC3/NDUFB3/PSMB7/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/CALM1/NDUFS5/DKK2/BAD/SDHD/NDUFB10/ATP5MC2/IL1B/COX8A/ATP5PO/COX7A2L/MT-ND3/PSMB1/SOD1/UQCRH/NDUFA4L2/PRKN/ATP5PD/PSMA1/COX4I1/COX5A/GPX8/ATP5PB/PSMA5/NDUFB2/MAPK8/PPP3CA/PSMB4/VDAC2/PSMA3/NEFM/PSMA4/AMBRA1/PPP3CC/COX7C/NDUFS8/ATP5MC1/CAMK2D/PSMB5/NDUFA8/TUBB6/WIPI1/NDUFA5/EIF2AK3/ACTR10/ATP5F1A/TANK/PRKCG/FZD4/HIP1/CASP8/NDUFC1/GPX1/UQCR11/PRKCA/PLCB4/COX5B/CSNK2A1/CSF1/ATXN1/PSMD8/NDUFB9/MAPK10/NDUFS6/DCTN2/PRNP/PTGS2/FZD1/UBE2J1/ATP2A3/HTRA2/MCU/CAT/ATXN2/MAP1LC3B/WNT2B/WNT10A/DCTN6	6.95861279052369
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	100/1391	368/9376	1.83165067358485	UQCRB/NDUFA4/COX6C/ATP5F1E/MAP3K5/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/GPX7/COX6A1/CCS/NDUFA12/ATP5F1D/UQCRQ/NDUFV2/DCTN3/NDUFB7/COX7A1/NDUFB3/PSMB7/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/NDUFS5/BAD/SDHD/NDUFB10/ATP5MC2/COX8A/ATP5PO/COX7A2L/MT-ND3/PSMB1/SOD1/UQCRH/NDUFA4L2/PRKN/ATP5PD/PSMA1/COX4I1/COX5A/GPX8/ATP5PB/PSMA5/NDUFB2/PPP3CA/PFN1/PSMB4/SEC13/PSMA3/NEFM/PSMA4/AMBRA1/PPP3CC/COX7C/NDUFS8/ATP5MC1/PSMB5/NDUFA8/TUBB6/WIPI1/NDUFA5/EIF2AK3/ACTR10/ATP5F1A/TANK/ALYREF/NDUFC1/GPX1/UQCR11/ACTG1/COX5B/PSMD8/NDUFB9/NDUFS6/DCTN2/HNRNPA1/NUP37/NUP107/MCU/CAT/ATXN2/MAP1LC3B/NUP54/NUP88/DCTN6	6.79301239678801
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	101/1391	388/9376	1.75460804731447	APOE/WNT11/UQCRB/NDUFA4/PLCB1/COX6C/ATP5F1E/MAP3K5/COX7A2/ATP5F1C/UQCR10/NDUFA1/ATP5PF/NDUFB1/COX7B/NDUFAB1/NDUFS4/ATP5MC3/NDUFB11/SEM1/COX6B1/PSMA7/NDUFA2/COX6A1/NDUFA12/DKK1/ATP5F1D/UQCRQ/NDUFV2/NDUFB7/COX7A1/VDAC3/NDUFB3/PSMB7/NDUFB6/NDUFC2/NDUFB5/VDAC1/NDUFB4/CALM1/NDUFS5/DKK2/BAD/SDHD/NDUFB10/ATP5MC2/IL1B/COX8A/ATP5PO/COX7A2L/MT-ND3/PSMB1/UQCRH/NDUFA4L2/ATP5PD/SLC39A13/PSMA1/COX4I1/SLC39A4/COX5A/ATP5PB/PSMA5/NDUFB2/MAPK8/PPP3CA/PSMB4/VDAC2/PSMA3/PSMA4/AMBRA1/PPP3CC/COX7C/NDUFS8/ATP5MC1/PSMB5/NDUFA8/TUBB6/WIPI1/NDUFA5/EIF2AK3/ATP5F1A/FZD4/CASP8/NDUFC1/UQCR11/PLCB4/COX5B/CSNK2A1/CSF1/PSMD8/NDUFB9/MAPK10/NDUFS6/PTGS2/FZD1/PIK3R1/RTN3/ATP2A3/MCU/WNT2B/WNT10A	6.33603410386037
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	50/1391	157/9376	2.14664792318224	UQCRB/NDUFA4/COX6C/MAP3K5/COX7A2/UQCR10/NDUFA1/NDUFB1/COX7B/NDUFAB1/NDUFS4/NDUFB11/COX6B1/NDUFA2/COX6A1/NDUFA12/UQCRQ/NDUFV2/NDUFB7/COX7A1/NDUFB3/NDUFB6/NDUFC2/NDUFB5/NDUFB4/NDUFS5/SDHD/NDUFB10/IL1B/COX8A/COX7A2L/UQCRH/NDUFA4L2/COX4I1/COX5A/NDUFB2/MAPK8/COX7C/NDUFS8/NDUFA8/NDUFA5/EIF2AK3/CASP8/NDUFC1/UQCR11/COX5B/NDUFB9/MAPK10/NDUFS6/PIK3R1	6.04713620151238
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1391	142/9376	2.08859772582295	ELOB/RPS27A/UBB/UBA52/UBE2E1/RBX1/ANAPC11/NEDD4L/COP1/UBE2M/UBE2D2/UBE2E3/PRKN/FBXW11/CDC26/UBE2Q1/ELOC/RHOBTB1/UBE2B/UBE2E2/UBE2K/STUB1/CBLB/RNF7/UBA2/ANAPC16/UBE2N/UBE2Q2/UBE2R2/ANAPC10/ANAPC15/UBE2J1/CUL3/MID1/FBXO4/NEDD4/HERC1/HERC4/PIAS1/CDC27/UBR5/BIRC6/BTRC/UBE4B	5.4554226532451
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	43/1391	149/9376	1.94523760126219	NDUFA4/PLCB1/GNGT1/NDUFA1/NDUFB1/NDUFAB1/NDUFS4/GNG5/NDUFB11/NDUFA2/NDUFA12/GNAI1/NDUFV2/NDUFB7/NDUFB3/NDUFB6/NDUFC2/NDUFB5/NDUFB4/NDUFS5/NDUFB10/MT-ND3/NDUFA4L2/GNG11/NDUFB2/MAPK8/NDUFS8/NDUFA8/GNAI2/ADCY3/NDUFA5/PRKCG/NDUFC1/PRKCA/PRKACB/PLCB4/NDUFB9/MAPK10/NDUFS6/PTGS2/GNB1/GNB2/GABRG2	4.85417697885761
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	47/1391	174/9376	1.82070287645537	OSTC/HSP90B1/TMEM258/SEC62/MARCHF6/MAP3K5/SEC61G/SSR4/PDIA3/SELENOS/DDOST/DAD1/BAG2/SEC61B/CALR/TUSC3/LMAN2/PDIA6/SSR2/RBX1/P4HB/UBXN4/UBE2D2/PRKN/MAN1C1/MAPK8/SEC13/STUB1/SIL1/SEC24D/EIF2AK3/DNAJC1/DERL2/MAPK10/UFD1/KRTCAP2/STT3A/UBE2J1/ERLEC1/NGLY1/SAR1B/SSR3/SEC24B/DNAJA2/UBXN8/MOGS/UBE4B	4.56069687736682
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	46/1391	184/9376	1.68511861969806	EFNB2/MYL12A/NRP1/MYL9/MYL12B/EPHA3/PARD3/SLIT3/BMP7/ENAH/EFNA5/SLIT2/UNC5C/SEMA3C/GNAI1/PLXNA4/BOC/UNC5B/NFATC2/EPHA5/PTK2/SEMA3A/PLXNC1/PPP3CA/ITGB1/CFL1/TRPC1/NEO1/PPP3CC/SEMA3G/PAK5/CAMK2D/CXCR4/GNAI2/RGS3/ROCK2/RAC2/PRKCA/FYN/ILK/PIK3R1/RASA1/SSH2/PARD6G/EPHA4/ROCK1	3.91725115490358
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1391	31/9376	2.82665058788062	SEC62/SRP14/SEC61G/SEC11A/SPCS2/SEC61B/IMMP2L/SRP54/SPCS1/TMEM208/SRP9/IMMP1L/SRP19	4.25165893045364
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/1391	87/9376	1.93691795367593	CACNB2/UQCRB/COX6C/COX7A2/UQCR10/COX7B/COX6B1/COX6A1/RYR2/UQCRQ/ATP1B1/COX7A1/CACNA2D1/COX8A/COX7A2L/UQCRH/COX4I1/COX5A/COX7C/ATP1B3/SLC8A1/UQCR11/COX5B/TNNI3/ATP2A3	3.66427828594999
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1391	78/9376	1.9011594683773	HCLS1/ELMO1/ARPC2/PTK2/ARPC3/CAV2/ITGB1/ARPC5L/ARPC1A/SEPTIN11/CAV1/ACTG1/DNM3/ARPC5/ILK/CD2AP/ACTR3/PIK3R1/GAB1/CLTCL1/SEPTIN6/ARPC4	3.33553823673563
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	55/1391	253/9376	1.46532053886788	H3-3B/H3-3A/MYL12A/U2AF1/PLCB1/MYL9/MYL12B/RPS27A/UBB/UBA52/SEPTIN7/HCLS1/ELMO1/RBX1/ARPC2/VDAC1/RIPK1/IL1B/UBE2D2/PTK2/FBXW11/ARPC3/MAPK8/ITGB1/PFN1/BNIP3/HK1/ARPC5L/WIPI1/ROCK2/ARPC1A/SEPTIN11/PRKCE/ACTG1/PLCB4/UBE2N/MAPK10/CAST/PRKCQ/PLCD1/ARPC5/TLN2/ILK/ATG5/ACTR3/PIK3R1/MYL10/TIFA/SEPTIN6/ARPC4/FOXO3/MAP1LC3B/ROCK1/DIAPH1/BTRC	3.13152143296318
NA	NA	hsa04517	IgSF CAM signaling	63/1391	299/9376	1.42023375305656	MYL12A/NRP1/NCAM2/MYL6/ANK3/MYL9/MYL12B/PARD3/SLIT3/SLIT2/UNC5C/MAGI2/PTPRD/PLXNA4/RAP1B/ARPC2/UNC5B/RAP1A/PMP22/CD48/PTK2/SSX2IP/EPB41L2/ARPC3/CD96/MAPK8/ITGB1/IL1RAPL1/ICAM2/LYN/MYH10/PAK5/ARPC5L/EZR/TUBB6/CADM3/ARPC1A/PRKCG/MSN/DYNLL1/ACTG1/PRKCA/NCAM1/ICAM3/GRIP1/MAPK10/LCK/MYL6B/PRKCQ/FYN/SPTBN1/ARPC5/CD2AP/ACTR3/PIK3R1/RASA1/CD2/CRTAM/PTPRS/ITGAL/ARPC4/SH2D1B/PARD6G	3.08224460635875
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	41/1391	178/9376	1.55258120017125	WNT11/PLCB1/RSPO2/SERPINF1/CBY1/DKK1/RBX1/ROR2/DKK2/PRICKLE1/NFATC2/INVS/FBXW11/APCDD1/CTNND2/MAPK8/PPP3CA/LEF1/PPP3CC/CAMK2D/ROCK2/RAC2/PRKCG/ZNRF3/FZD4/CACYBP/PRKCA/PRKACB/PLCB4/DAAM1/CSNK2A1/MAPK10/FZD1/CCDC88C/DAAM2/CCND3/NKD2/TCF7L1/WNT2B/WNT10A/BTRC	3.10649848986127
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/1391	30/9376	2.47150730889049	PDHB/SDHD/SUCLA2/MDH1/SUCLG2/IDH2/SUCLG1/MDH2/FH/IDH3G/ACO1	3.36916209146863
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	45/1391	203/9376	1.49419384997857	LAMA2/MYL12A/EMP2/VTN/COL6A3/COL4A4/MYL9/MYL12B/COL4A2/LAMB1/LAMA4/LAMC3/PPP1CA/RAP1B/RAP1A/BAD/VEGFC/PTK2/CAV2/MAPK8/ITGB1/PDGFRA/SOS1/ITGB8/PAK5/ROCK2/RAC2/PRKCG/CAV1/ACTG1/PRKCA/COL9A1/MAPK10/PARVA/FYN/TLN2/ILK/VWF/PIK3R1/MYL10/CCND3/COL4A3/PARVB/ROCK1/DIAPH1	2.97099144780799
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/1391	53/9376	2.03486022001275	PLCB1/ATP2B1/ATP1B1/AP2S1/ATP1B3/SLC8A1/PRKCG/RAB11A/PRKCA/PRKACB/PLCB4/DNM3/GNAS/ATP2B3/CLTCL1/ESR1	3.15321459919097
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	34/1391	144/9376	1.59150091860372	PLCB1/MAP3K5/RORA/SEM1/PSMA7/VDAC3/PSMB7/VDAC1/ATXN10/MYOD1/PSMB1/PSMA1/PSMA5/MAPK8/PSMB4/VDAC2/PSMA3/PSMA4/AMBRA1/PSMB5/WIPI1/DAB1/PRKCG/PRKCA/PLCB4/ATXN1/PSMD8/MAPK10/PIK3R1/KCND3/ATP2A3/MCU/ATXN2/BEAN1	2.98538615582404
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	24/1391	93/9376	1.73947728484961	MYL12A/MYL9/MYL12B/PARD3/RAP1B/RAP1A/SSX2IP/PDCD10/FER/SNAI2/LEF1/ROCK2/RAC2/ACTG1/CSNK2A1/ACP1/FYN/CCM2/YES1/MYL10/WASF3/PTPRM/TCF7L1/ROCK1	2.99112029768268
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/1391	32/9376	2.31703810208483	PCCA/SUCLA2/LDHB/ECHDC1/SUCLG2/HIBCH/SUCLG1/ECHS1/HADHA/ACSS3/BCKDHB	3.11471745425981
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1391	116/9376	1.62701108108778	MYL12A/MYL9/MYL12B/VCAM1/GNAI1/RAP1B/RAP1A/CYBA/RHOH/THY1/PTK2/ITGB1/CXCR4/EZR/GNAI2/ROCK2/RAC2/PRKCG/MSN/ACTG1/PRKCA/TXK/PIK3R1/MYL10/ITK/ITGAL/RAPGEF3/ROCK1	2.83602764773306
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	49/1391	232/9376	1.42363469595181	C7/TMSB4X/MYL12A/MYL9/MYL12B/CYRIB/C6/LPAR1/ENAH/GSN/PPP1CA/DIAPH2/FGF7/ARPC2/FGFR2/PTK2/ARPC3/ITGB1/PFN1/CFL1/PDGFRA/SOS1/ITGB8/MYH10/PAK5/CXCR4/ARPC5L/EZR/BRK1/ROCK2/RAC2/ARPC1A/MSN/CHRM2/PIP4K2A/ACTG1/CYRIA/ARPC5/ITGAE/ACTR3/PIK3R1/MYL10/FGFR3/RGCC/SSH2/ITGAL/ARPC4/ROCK1/DIAPH1	2.7269623922728
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/1391	51/9376	1.98249249376242	SEC61G/KCNQ1/KDELR2/SEC61B/CFTR/ATP6V1G1/ATP6V1D/ADCY3/KDELR3/ACTG1/PRKCA/PRKACB/GNAS/TCIRG1/ATP6V1F	2.93630829385379
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	14/1391	48/9376	1.96597172298107	ALDH2/PCCA/AUH/HMGCLL1/HIBCH/ECHS1/HIBADH/HADHA/HMGCL/OXCT1/ALDH7A1/ACAA1/ACADM/BCKDHB	2.80028675584999
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/1391	248/9376	1.38614596136453	MYL12A/HSP90B1/MYL9/MYL12B/S100A10/DYNLT1/TXN/ELMO1/EXOC4/DCTN3/ARPC2/RALA/RIPK1/RHOH/RAB9A/IL1B/DYNLT3/RPS3/ACBD3/DYNC1I2/ARPC3/MAPK8/PFN1/LEF1/ARPC5L/TUBB6/BRK1/ROCK2/ACTR10/ARPC1A/PTPRC/CASP8/DYNLL1/ACTG1/MAPK10/DCTN2/MAP2K4/ARPC5/KPNA3/ACTR3/ANXA2/MYL10/DYNC1LI1/WASF3/RAB7A/ABI1/ARPC4/STX10/TCF7L1/VPS41/DCTN6	2.57217945276891
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1391	126/9376	1.55137904670615	MYL12A/PLCB1/PRKG1/MYL12B/GUCY1A2/PPP1CA/GNAI1/RAP1B/RAP1A/VAMP8/ITGB1/LYN/P2RX1/GNAI2/ADCY3/ROCK2/RASGRP1/ACTG1/PRKACB/PLCB4/GNAS/FYN/TLN2/VWF/PIK3R1/GUCY1B1/PLA2G4C/ROCK1/ORAI1	2.60061706092616
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/1391	44/9376	1.99150382327952	ARHGDIG/DYNC1I2/ADCY3/DYNLL1/RAB11A/PRKACB/GNAS/DCTN2/DYNC1LI1/ARHGDIB/RAB11B/CREB5/DCTN6	2.75134536716598
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	51/1391	250/9376	1.37505679367362	ARF5/PARD3/CHMP5/ARPC2/FGFR2/NEDD4L/SMAP1/VPS29/AP2S1/ARF4/PSD3/CHMP2A/ASAP1/ARPC3/CAV2/WASHC3/PDGFRA/GRK5/CBLB/CXCR4/ARPC5L/VPS25/WIPF1/SMAP2/ARPC1A/SNX6/STAMBP/CAV1/SNF8/RAB11A/DNM3/IL2RG/CAPZA2/AGAP1/ARPC5/GIT2/ACTR3/ACAP2/EPN2/CHMP6/SNX4/FGFR3/STAM/NEDD4/RAB31/CLTCL1/SH3KBP1/RAB7A/ARPC4/RAB11B/PARD6G	2.50864120648338
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	34/1391	157/9376	1.45972058776392	WNT11/CCN2/PARD3/BMP7/BMP4/FRMD6/STK3/ID1/PPP1CA/BMP5/PALS1/TGFB3/FBXW11/SNAI2/LEF1/DLG1/YWHAB/WWC1/FZD4/YAP1/ACTG1/ID2/WTIP/FZD1/YWHAH/LATS2/TEAD2/CCND3/NKD2/TCF7L1/WNT2B/PARD6G/WNT10A/BTRC	2.42445213796104
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/1391	46/9376	1.90491670052824	SEM1/PSMA7/PSMB7/POMP/PSMB1/PSMA1/PSMA5/PSMB4/PSMA3/PSMA4/PSMB5/PSMD8/IFNG	2.56778371524838
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1391	56/9376	1.80548423539078	OSTC/TMEM258/DDOST/DAD1/TUSC3/ALG5/DPM3/MAN1C1/DHRSX/KRTCAP2/STT3A/DPM1/DOLPP1/B4GALT1/MOGS	2.52321841335006
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	28/1391	125/9376	1.50986628324946	PLCB1/MAP3K5/GNAI1/CERS4/ORMDL1/PPP2R5E/MAPK8/S1PR3/GNAI2/ROCK2/RAC2/PRKCG/CERS6/CERS5/PRKCE/PRKCA/PLCB4/GAB2/MAPK10/FYN/SGMS1/DEGS1/S1PR2/PIK3R1/S1PR5/ORMDL2/PPP2R3C/ROCK1	2.3951278607529
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	23/1391	98/9376	1.58194809196144	MYO10/GSN/ARPC2/PLPP1/ASAP1/ARPC3/CFL1/LYN/FCGR3B/ARPC5L/RAC2/ARPC1A/PRKCG/PTPRC/PRKCE/PRKCA/GAB2/ARPC5/ACTR3/PIK3R1/PLA2G4C/WASF3/ARPC4	2.41702891164194
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	47/1391	233/9376	1.35966652576496	LAMA2/VCAN/NID2/VIM/PDLIM1/NEBL/ANK3/SGCE/COL6A3/COL4A4/MYL9/BGN/COL4A2/SSPN/DES/COL5A2/SNTB1/SGCB/DIAPH2/ATP1B1/TTN/FHL2/TRIM63/COL5A3/ITGB1/SGCD/ITGB8/MYH10/FHL3/ATP1B3/COL11A1/ACTG1/DAAM1/COL9A1/CAPZA2/SPTBN1/TLN2/TNNI3/SNTB2/FMNL2/DAAM2/ANKRD23/COL4A3/DTNA/TMOD1/CSRP2/DIAPH1	2.32030653616753
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	22/1391	93/9376	1.59452084444548	MAML2/MAML3/CD247/NFATC2/STAT4/JAK1/NOTCH3/MAPK8/PPP3CA/PPP3CC/CD3E/RUNX3/CD3D/JAK2/MAPK10/IL2RG/LCK/PRKCQ/CD3G/IFNG/TBX21/STAT1	2.40478430054544
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	26/1391	116/9376	1.51079600386723	ESD/PDHB/PGLS/PCCA/GCSH/SDHD/SUCLA2/MDH1/HK1/SUCLG2/PHGDH/HIBCH/IDH2/SUCLG1/CPS1/MDH2/ECHS1/FH/IDH3G/IDNK/ME3/TALDO1/ACO1/GOT1/CAT/RPIA	2.31037637613331
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	23/1391	102/9376	1.51991091188452	PLCB1/PLA2G2A/KCNQ1/ATP2B1/CFTR/RYR2/ATP1B1/RAP1B/RAP1A/TRPC1/BST1/ADCY3/ATP1B3/PRKCG/PLA2G5/RAB11A/PRKCA/PLCB4/GNAS/SCT/ATP2B3/ATP2A3/CD38	2.20347037312769
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	17/1391	70/9376	1.63697237342097	LAMA2/SGCE/SSPN/SNTB1/SGCB/CD40/PRF1/SGCD/RAC2/CAV1/CASP8/ACTG1/FYN/SNTB2/EIF4G3/ITGAL/DTNA	2.23254301607723
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1391	170/9376	1.3877447456337	MYL12A/MYL6/MYL9/MYL12B/MAP3K5/PARD3/CFTR/HCLS1/ARPC2/RAP1A/NEDD4L/EPB41L4B/PALS1/ARPC3/MAPK8/ITGB1/MYH10/ARPC5L/EZR/DLG1/RAB13/ROCK2/ARPC1A/MSN/PRKCE/ACTG1/PRKACB/MAPK10/MYL6B/ARPC5/ACTR3/NEDD4/ARPC4/PARD6G/ROCK1	2.12934797846692
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	18/1391	76/9376	1.59642816602974	PLCB1/HRH2/KCNQ1/CFTR/GNAI1/ATP1B1/CALM1/CAMK2D/EZR/GNAI2/ADCY3/ATP1B3/PRKCG/ACTG1/PRKCA/PRKACB/PLCB4/GNAS	2.17888951704867
NA	NA	hsa04518	Integrin signaling	32/1391	154/9376	1.40061807351527	LAMA2/VTN/COL6A3/COL4A4/COL4A2/LAMB1/VCAM1/LIMS1/FERMT2/LAMA4/LAMC3/VEGFC/PTK2/ITGB1/ICAM2/PDGFRA/ITGB8/RAC2/ACTG1/COL9A1/ICAM3/PARVA/TLN2/ILK/ITGAE/VWF/FREM1/PIK3R1/ITGAL/CCND3/COL4A3/PARVB	2.09213681923034
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	32/1391	154/9376	1.40061807351527	CACNB2/PLCB1/MYL6/MYL9/MAP2K5/GUCY1A2/PPP1CA/RYR2/GNAI1/CALM1/CACNA2D1/NFATC2/PPP3CA/CAMK4/CAMK1D/PPP3CC/CAMK2D/GNAI2/ADCY3/ROCK2/PRKCG/ACTG1/PRKCA/PRKACB/PLCB4/GNAS/MYL6B/PTGS2/GUCY1B1/PLA2G4C/CD38/ROCK1	2.09213681923034
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	42/1391	212/9376	1.33537701938337	PLCB1/PARD3/LPAR1/ENAH/EFNA5/MAGI3/KITLG/ID1/MAGI2/GNAI1/PRKD1/FGF7/RAP1B/DOCK4/RAP1A/CALM1/RALA/FGFR2/VEGFC/SKAP1/ANGPT2/RAP1GAP/ITGB1/ANGPT1/PFN1/PDGFRA/GNAI2/ADCY3/RAC2/PRKCG/ACTG1/PRKCA/PLCB4/GNAS/CSF1/TLN2/PIK3R1/FGFR3/ITGAL/EVL/RAPGEF3/PARD6G	2.06143874231685
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	23/1391	105/9376	1.47648488583068	LAMA2/CACNB2/SGCE/SSPN/DES/SNTB1/SGCB/RYR2/TTN/CACNA2D1/TGFB3/ITGB1/SGCD/ITGB8/ADCY3/SLC8A1/ACTG1/PRKACB/GNAS/TNNI3/SNTB2/ATP2A3/DTNA	2.04923720094019
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	26/1391	122/9376	1.43649456105408	CD247/NFATC2/MAP3K8/PPP2R5E/MAPK8/PPP3CA/SOS1/PPP3CC/PAK5/CBLB/CD3E/DLG1/CD3D/PTPRC/CARD11/RASGRP1/MAPK10/LCK/PRKCQ/FYN/CD3G/PIK3R1/ITK/PPP2R3C/GRAP2/IFNG	2.02537640956688
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1391	134/9376	1.40845735377748	PLCB1/MYL6/PPP1R14A/CALD1/PRKG1/MYL9/PLA2G2A/GUCY1A2/PPP1CA/CALM1/PRKCH/MYH10/ADCY3/ROCK2/PRKCG/RAMP2/PLA2G5/PRKCE/PRKCA/PRKACB/PLCB4/GNAS/MYL6B/PRKCQ/IRAG1/GUCY1B1/PLA2G4C/ROCK1	1.98759492630251
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1391	47/9376	1.72097220735121	GRHPR/ALDH2/ACYP2/PDHB/LDHB/MDH1/AKR1A1/MDH2/GLO1/FH/ME3/ALDH7A1	2.06805292489514
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	33/1391	166/9376	1.33997384216954	PDE3A/PLCB1/PRKG1/MYL9/GUCY1A2/ATP2B1/PPP1CA/GNAI1/PDE3B/ATP1B1/VDAC3/VDAC1/CALM1/BAD/NFATC2/PDE5A/PPP3CA/VDAC2/PPP3CC/GNAI2/ADCY3/ATP1B3/ROCK2/SLC8A1/PRKCE/PLCB4/ATP2B3/IRAG1/GUCY1B1/ATP2A3/KCNJ8/ROCK1/CREB5	1.84451195872253
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/1391	86/9376	1.48917459415177	LAMA2/CACNB2/SGCE/SSPN/DES/SNTB1/SGCB/RYR2/CACNA2D1/ITGB1/LEF1/SGCD/ITGB8/SLC8A1/ACTG1/SNTB2/ATP2A3/DTNA/TCF7L1	1.90202843355137
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/1391	28/9376	1.9258498510835	AKR1B1/PTS/GPHN/ALPL/MOCS2/PCBD1/DHFR/QDPR	2.04772658116347
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1391	10/9376	2.69618979151689	BPNT2/SELENBP1/PAPSS1/PAPSS2	2.23979933477859
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1391	105/9376	1.41228989079456	TOMM7/RPS27A/UBB/UBA52/ARIH1/MARCHF5/GABARAPL2/MTX2/FIS1/PRKN/MAPK8/BNIP3/AMBRA1/EIF2AK3/CSNK2A1/MAPK10/FUNDC1/SAMM50/RAB7A/FOXO3/MAP1LC3B/CITED2	1.77315127281502
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	42/1391	224/9376	1.26383896477354	NRP1/TSPO/CALR/CD40/VDAC3/ANAPC11/VDAC1/ETS1/NFATC2/JAK1/TGFB3/CDC26/MAPK8/PPP3CA/VDAC2/RANBP1/PPP3CC/ADCY3/CD3E/DLG1/CD3D/PRKACB/ANAPC16/MAPK10/IL2RG/LCK/CRTC3/MAP2K4/ANAPC10/TLN2/IL15/CD3G/ANAPC15/PIK3R1/ITGAL/CCND3/CDKN2A/MSX1/CCNB2/FDPS/CDC27/CREB5	1.66807925251384
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	17/1391	78/9376	1.46907777101882	LSM7/LSM6/LSM5/ZCCHC7/PAN3/LSM3/LSM1/EXOSC8/C1D/TENT4B/XRN2/HSPD1/DCPS/CNOT4/CNOT2/EXOSC1/EXOSC7	1.73623747642956
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	28/1391	142/9376	1.32910764370551	HSP90B1/MAP3K5/VCAM1/MAP2K5/BMP4/SUMO2/TXN/CALM1/SUMO1/CYBA/IL1B/MGST1/PTK2/CAV2/MAPK8/GSTT1/GSTA4/RAC2/GSTP1/MGST2/ACVR1/CAV1/ACTG1/MAPK10/MAP2K4/PIK3R1/NQO1/IFNG	1.64929730444722
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	30/1391	154/9376	1.31307944392057	NME3/EPRS1/ADSS2/PTS/ALDH2/GPHN/ALPL/MOCS2/MTHFD1L/GSS/QPRT/NME7/HAAO/PMM1/AKR1A1/GUSB/MMAB/VKORC1L1/PPCS/DHFR/AFMID/COQ5/PPCDC/HSD17B6/PMM2/NQO1/NME1/UROS/IDO2/COQ7	1.63498622571607
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	40/1391	214/9376	1.25990177173687	GNGT1/ELOB/PDIA3/GNG5/CALR/GNAI1/CD247/RBX1/CALM1/AP1S2/BAD/RIPK1/NFATC2/PTK2/GNG11/FBXW11/APOBEC3G/ELOC/MAPK8/PPP3CA/CFL1/PPP3CC/PAK5/CXCR4/GNAI2/CD3E/RNF7/RAC2/CD3D/PRKCG/AP1S1/CASP8/PRKCA/MAPK10/GNB1/CD3G/PIK3R1/CCNB2/GNB2/BTRC	1.60521321337052
Human Diseases	Substance dependence	hsa05032	Morphine addiction	19/1391	91/9376	1.40735181425332	PDE3A/GNGT1/PDE4D/GNG5/PDE4B/GNAI1/PDE3B/GNG11/GRK5/GNAI2/ADCY3/PRKCG/PRKCA/PRKACB/GNAS/PDE7A/GNB1/GNB2/GABRG2	1.62971303794731
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1391	63/9376	1.49788321750939	POLR2L/ERCC1/POLR2G/RBX1/POLR2K/MNAT1/POLR2J/GTF2H5/CCNH/RPA3/POLR2I/RFC1/POLR2F/RFC2	1.65487312712096
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1391	97/9376	1.3897885523283	PLCB1/GNGT1/PRKG1/GUCY1A2/GNG5/RYR2/GNAI1/CALM1/GNG11/CAMK2D/GNAI2/ADCY3/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/GNB1/GUCY1B1/GNB2	1.61055701180336
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1391	31/9376	1.73947728484961	GRHPR/PCCA/GCSH/MDH1/MDH2/AFMID/ACO1/CAT	1.72118588133832
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1391	69/9376	1.46532053886788	PDE3A/PLCB1/GUCY1A2/GNAI1/PDE3B/CALM1/PPP3CA/PTGER4/PPP3CC/GNAI2/PRKACB/PLCB4/GNAS/GUCY1B1/ORAI1	1.61913721054515
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1391	21/9376	1.9258498510835	CSGALNACT1/B3GAT3/CSGALNACT2/XYLT2/CHSY3/CHST15	1.77271963663487
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	23/1391	115/9376	1.34809489575845	PLCB1/GNGT1/KCNQ1/GNG5/GNAI1/GNG11/CAMK4/CAMK2D/GNAI2/ADCY3/CHAT/JAK2/KCNQ5/PRKCG/CHRM2/PRKCA/PRKACB/PLCB4/GNB1/FYN/PIK3R1/GNB2/CREB5	1.56757878093779
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1391	98/9376	1.37560703648821	PLCB1/HSD3B2/ATP2B1/PRKD1/ATP1B1/CALM1/CAMK4/CAMK1D/CAMK2D/ADCY3/ATP1B3/PRKCG/PRKCE/PRKCA/PRKACB/PLCB4/GNAS/ATP2B3/CREB5/ORAI1	1.56002413127304
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	36/1391	193/9376	1.25729057635503	PLCB1/GNGT1/PARD3/GNG5/GNAI1/ELMO1/RAP1B/RAP1A/XCL1/BAD/PTK2/GNG11/CCL3L1/CCL4L2/LYN/SOS1/GRK5/CXCR4/GNAI2/ADCY3/XCL2/ROCK2/CXCL14/RAC2/JAK2/CX3CR1/PRKACB/PLCB4/GNB1/STAT2/PIK3R1/ITK/FOXO3/GNB2/ROCK1/STAT1	1.50737734965152
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/1391	42/9376	1.60487487590291	ALDH2/KYAT3/HAAO/ECHS1/AFMID/HADHA/ALDH7A1/CAT/IDO2/MAOB	1.63971374015225
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1391	122/9376	1.32599497943454	SLC16A10/PLCB1/BMP4/NCOR1/NCOA1/ATP1B1/MED30/BAD/NOTCH3/ATP1B3/PRKCG/ACTG1/PRKCA/PRKACB/PLCB4/NCOA3/NCOA2/PLCD1/MED27/PIK3R1/ATP2A3/ESR1/DIO1/STAT1	1.51264780800361
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/1391	37/9376	1.63957487321973	PLCB1/VCAM1/LAMA4/IL1B/PRKCG/PRKCA/PLCB4/IFNG/IDO2	1.62687359619559
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	25/1391	128/9376	1.31649892163911	NME3/PDE3A/PDE4D/GUCY1A2/ADSS2/PDE4B/GUK1/PDE3B/PAPSS1/HDDC2/DGUOK/ADK/APRT/PDE5A/PAPSS2/NME7/ADCY3/NT5C2/NT5C/PDE7A/NTPCR/FHIT/GUCY1B1/PGM1/NME1	1.50475242500789
Organismal Systems	Digestive system	hsa04970	Salivary secretion	19/1391	93/9376	1.37708618383927	PLCB1/PRKG1/GUCY1A2/ATP2B1/ATP1B1/CALM1/BST1/ADCY3/ATP1B3/PRKCG/CST3/PRKCA/PRKACB/PLCB4/GNAS/LYZ/ATP2B3/GUCY1B1/CD38	1.52528030483958
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1391	12/9376	2.24682482626408	VKORC1L1/COQ5/NQO1/COQ7	1.80375315879809
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1391	99/9376	1.36171201591762	PLCB1/PPP1CA/CALM1/IL1B/PRKCH/MAPK8/TRPA1/PTGER4/CAMK2D/ADCY3/PRKCG/PRKCE/PRKCA/PRKACB/PLCB4/GNAS/MAPK10/PRKCQ/PIK3R1/PLA2G4C	1.51004016135171
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	20/1391	99/9376	1.36171201591762	LAMA2/CACNB2/SGCE/SSPN/DES/SNTB1/SGCB/RYR2/TTN/CACNA2D1/TGFB3/ITGB1/SGCD/ITGB8/SLC8A1/ACTG1/TNNI3/SNTB2/ATP2A3/DTNA	1.51004016135171
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1391	27/9376	1.74753042042762	SCD5/SCP2/FADS2/HSD17B12/ELOVL1/ACAA1/HACD3	1.62345373225857
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	43/1391	238/9376	1.21781681759692	GNGT1/PLA2G2A/GNG5/EFNA5/KITLG/FGF7/RAP1B/RAP1A/CALM1/RALA/FGFR2/BAD/VEGFC/ETS1/ANGPT2/GNG11/MAPK8/ANGPT1/PDGFRA/SOS1/PAK5/RASAL2/RAC2/PRKCG/RASA2/PLA2G5/PLAAT2/RASGRP1/PRKCA/PRKACB/GAB2/CSF1/MAPK10/GNB1/PIK3R1/RASA1/GAB1/FGFR3/PLA2G4C/REL/NF1/GNB2/SHOC2	1.42058116803314
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	12/1391	54/9376	1.49788321750939	KYAT3/CISD1/GSS/LDHB/APIP/MDH1/PHGDH/AHCYL2/MDH2/ADI1/GOT1/CDO1	1.5313750287734
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1391	17/9376	1.98249249376242	KYAT3/PAPSS1/PAPSS2/MARS1/TXNRD2	1.69219622181797
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	41/1391	226/9376	1.22282944084284	PDE3A/MYL9/PDE4D/FXYD1/SSTR1/PDE4B/ATP2B1/CFTR/PPP1CA/RYR2/GNAI1/PDE3B/ATP1B1/RAP1B/RAP1A/CALM1/BAD/MAPK8/CAMK4/NPY1R/CAMK2D/GNAI2/ADCY3/ATP1B3/ROCK2/RAC2/GLI3/CHRM2/PRKACB/GNAS/SOX9/MAPK10/ATP2B3/TNNI3/GIP/PIK3R1/ATP2A3/RAPGEF3/ROCK1/CREB5/ORAI1	1.41523312776268
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/1391	227/9376	1.21744252700653	PLCB1/GNGT1/PDIA3/GNG5/CALR/GNAI1/AKAP13/CALM1/RIPK1/IL1B/NFATC2/JAK1/PTK2/GNG11/CCL3L1/CDK6/CCL4L2/PPP3CA/PDGFRA/SOS1/PTGER4/PPP3CC/CXCR4/GNAI2/ADCY3/ROCK2/RAC2/PRKCG/CASP8/PRKCA/PRKACB/PLCB4/GNAS/PTGS2/GNB1/EIF4EBP1/PIK3R1/CDKN2A/GNB2/ROCK1/CREB5	1.38414740972049
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1391	33/9376	1.63405441910115	VAMP5/STX8/VAMP8/STX18/VTI1A/USE1/STX5/BNIP1	1.52283227332097
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/1391	90/9376	1.34809489575845	CD247/EML4/NFATC2/JAK1/PPP3CA/PPP3CC/CD3E/CD3D/JAK2/RASGRP1/CSNK2A1/LCK/ALK/PRKCQ/CD3G/PIK3R1/IFNG/STAT1	1.38489329660948
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1391	67/9376	1.40845735377748	PLCB1/PPP1CA/RAP1B/RAP1A/CALM1/PPP3CA/CAMK4/PPP3CC/CAMK2D/PRKCG/PRKCA/PRKACB/PLCB4/RAPGEF3	1.40037499866625
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1391	34/9376	1.58599399500994	POLR1F/POLR2L/POLR1D/POLR2G/POLR2K/POLR2J/POLR2I/POLR2F	1.42864536193287
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/1391	29/9376	1.62701108108778	FRMD6/STK3/WWC1/YAP1/WTIP/LATS2/TEAD2	1.41139910172138
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1391	57/9376	1.4190472586931	SCD5/CBR4/ECHS1/SCP2/HADHA/FADS2/HSD17B12/ELOVL1/ACAA1/HACD3/ACADM/MECR	1.32442545417085
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1391	75/9376	1.34809489575845	PLCB1/HSP90B1/GPX7/ATP1B1/GPX8/ADCY3/ATP1B3/PRKCG/GPX1/PRKCA/PRKACB/PLCB4/GNAS/SLC26A4/CREB5	1.26320898937324
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1391	19/9376	1.77380907336638	NAGLU/GUSB/HYAL2/ARSB/HGSNAT	1.40913968676666
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1391	130/9376	1.24439528839241	PLCB1/GNGT1/COL4A4/COL4A2/GNG5/GNAI1/VEGFC/GNG11/MAPK8/MMP1/SOS1/GNAI2/ADCY3/PRKCA/PRKACB/PLCB4/GNAS/MAPK10/MAP2K4/GNB1/PIK3R1/COL4A3/GNB2/CREB5	1.17111435286733
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1391	59/9376	1.37094396178825	GPX7/MGST1/GSS/GPX8/GSTT1/GSTA4/GSTP1/IDH2/MGST2/GPX1/GGT5/GSTK1	1.19291090053398
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1391	101/9376	1.26801005046587	WNT11/PLCB1/KITLG/GNAI1/CALM1/LEF1/CAMK2D/GNAI2/ADCY3/PRKCG/FZD4/PRKCA/PRKACB/PLCB4/GNAS/FZD1/TCF7L1/WNT2B/WNT10A	1.13022927266027
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	17/1391	89/9376	1.28750636111762	PLCB1/PRKG1/MAP2K5/GUCY1A2/LPAR1/GNAI1/PDGFRA/SOS1/GNAI2/ADCY3/TUBB6/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/GUCY1B1	1.13740853142027
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1391	20/9376	1.68511861969806	DHCR24/EBP/LIPA/CYP2R1/MSMO1	1.28011033791462
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1391	31/9376	1.52204262424341	PGLS/DERA/IDNK/TALDO1/PGM1/RBKS/RPIA	1.21509127151525
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1391	60/9376	1.34809489575845	PLCB1/PRKG1/GUCY1A2/GNAI1/LYN/GNAI2/PRKCG/PRKCA/PLCB4/GNAS/GUCY1B1/PLA2G4C	1.1289384983597
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/1391	15/9376	1.79745986101126	ALPL/THTPA/ACP1/NTPCR	1.2900456615681
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	24/1391	133/9376	1.21632622173694	PLCB1/GNGT1/GNG5/PPP1CA/GNAI1/CALM1/PPP2R5E/GNG11/MAPK8/PPP3CA/PPP3CC/CAMK2D/GNAI2/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/MAPK10/GNB1/PPP2R3C/GNB2/MAOB/CREB5	1.04867339991853
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/1391	26/9376	1.55549411049052	PLA2G2A/PLA2G5/PLAAT2/FADS2/PLA2G4C/ACAA1	1.18378292205073
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/1391	103/9376	1.24338849608789	PLCB1/CALR/GNAI1/CD247/IL1B/TGFB3/CCL3L1/MAPK8/GNAI2/CD3E/CD3D/CASP8/PLCB4/GNAS/MAPK10/MAP2K4/CD3G/PIK3R1/IFNG	1.03662164448557
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1391	103/9376	1.24338849608789	LAMA2/PLCB1/COL4A4/COL4A2/LAMB1/LAMA4/LAMC3/IL1B/PTK2/TGFB3/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/PIK3R1/RAB7A/COL4A3/IFNG	1.03662164448557
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1391	85/9376	1.26879519600795	NME3/ADSS2/GUK1/HDDC2/DGUOK/ADK/APRT/NME7/NT5C2/NT5C/DUT/DCTD/NTPCR/DTYMK/NME1/NT5C3A	1.0389902650071
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1391	21/9376	1.60487487590291	DPYD/ALDH2/PPCS/VNN2/PPCDC	1.158150610453
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1391	116/9376	1.22025831081584	PLCB1/GNGT1/GNG5/GNAI1/GRIK1/SLC38A1/GNG11/PPP3CA/TRPC1/PPP3CC/GNAI2/ADCY3/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/GNB1/GRIK2/PLA2G4C/GNB2	0.996248197133922
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1391	38/9376	1.4190472586931	ATP1B1/NEDD4L/ATP1B3/PRKCG/PRKCA/SFN/PIK3R1/SGK1	1.08028814554086
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1391	38/9376	1.4190472586931	CD40/IL7R/CD3E/CD3D/PTPRC/IL2RG/LCK/ORAI1	1.08028814554086
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1391	110/9376	1.22554081432586	FMOD/ID4/FST/BMP7/BMP4/EMP3/ID1/BMP5/NCOR1/ID3/RBX1/TGFB3/NEO1/NBL1/ACVR1/IGSF1/ID2/SMAD9/IFNG/ROCK1	0.993086508245591
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1391	44/9376	1.37873341611659	OSTC/TMEM258/DDOST/DAD1/TUSC3/MAN1C1/KRTCAP2/STT3A/B4GALT1	1.05095553376355
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	27/1391	154/9376	1.18177149952851	CACNB2/PLCB1/KCNQ1/ATP2B1/PPP1CA/RYR2/GNAI1/ATP1B1/CALM1/CACNA2D1/PPP2R5E/CAMK2D/GNAI2/ADCY3/ATP1B3/SLC8A1/PRKCA/PRKACB/PLCB4/GNAS/ATP2B3/TNNI3/ATP2A3/CREM/PPP2R3C/RAPGEF3/CREB5	0.949260335444672
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1391	80/9376	1.26383896477354	FGFR2/BAD/JAK1/RPS6/PDGFRA/SOS1/JAK2/PRKCG/PRKCA/EIF4EBP1/PIK3R1/GAB1/FGFR3/FOXO3/NF1	0.989116879348216
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	21/1391	117/9376	1.20982875260373	H2AJ/H2AZ1/MACROH2A1/H2AZ2/BCL7C/H2AC20/CDK2AP1/ZNHIT1/H2AX/BRD7/ACTR6/ACTG1/MORF4L1/SMARCA1/PHF6/INO80C/BRD9/PBRM1/MTA3/EPC1/SMARCD3	0.953207894683881
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1391	28/9376	1.44438738831262	ECHS1/HADHA/HSD17B12/ELOVL1/HACD3/MECR	0.982863329638859
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	24/1391	138/9376	1.1722564310943	PPP1CA/RBX1/ANAPC11/CALM1/PPP2R5E/FBXW11/CDC26/PPP3CA/PPP3CC/CAMK2D/ADCY3/YWHAB/SPDYE2/SPDYE21/PRKACB/ANAPC16/ANAPC10/YWHAH/ANAPC15/SPDYE1/SPDYE18/CCNB2/CDC27/BTRC	0.850820121510317
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/1391	70/9376	1.25180240320427	ELOB/RAP1B/RBX1/RAP1A/BAD/ETS1/TGFB3/ELOC/SOS1/PAK5/FH/PIK3R1/GAB1	0.88254957383157
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1391	34/9376	1.3877447456337	RORA/CRY1/RBX1/FBXW11/NR1D2/RORB/BTRC	0.945316397745721
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/1391	101/9376	1.20127267938872	PLCB1/COL4A4/COL4A2/VCAM1/VEGFC/IL1B/TGFB3/MAPK8/JAK2/PRKCE/PRKCA/PLCB4/MAPK10/PLCD1/PIK3R1/COL4A3/DIAPH1/STAT1	0.848790086925727
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1391	89/9376	1.21177069281658	GNGT1/GNG5/GPHN/GNAI1/GABARAPL2/SLC38A1/GNG11/PLCL1/GNAI2/ADCY3/PRKCG/PRKCA/PRKACB/GNB1/GNB2/GABRG2	0.837789438042461
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/1391	83/9376	1.21815803833595	SOD1/HMGCLL1/IDH2/SCP2/GSTK1/DHRS4/HMGCL/PEX7/EPHX2/ACAA1/ACOX2/ABCD3/PEX6/CAT/PXMP2	0.83318998368538
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1391	59/9376	1.25669863163923	NME3/DPYD/HDDC2/NME7/NT5C2/NT5C/DUT/DCTD/DTYMK/NME1/NT5C3A	0.82551174133789
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1391	59/9376	1.25669863163923	PRKG1/GNAI1/PDE3B/NPY1R/GNAI2/ADCY3/PLAAT2/PRKACB/GNAS/PTGS2/PIK3R1	0.82551174133789
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/1391	109/9376	1.17494509263351	RORA/CD247/IL1B/NFATC2/JAK1/MAPK8/PPP3CA/PPP3CC/CD3E/CD3D/JAK2/MAPK10/IL2RG/LCK/PRKCQ/CD3G/IFNG/TBX21/STAT1	0.76675598580681
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1391	60/9376	1.23575365444524	BAD/NFATC2/PTK2/PPP3CA/PPP3CC/RAC2/PRKCG/PRKCA/PTGS2/PIK3R1/PLA2G4C	0.764594309986421
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1391	110/9376	1.16426377360957	GNAI1/PDE3B/ANAPC11/CDC26/MAPK8/GNAI2/ADCY3/SPDYE2/SPDYE21/PRKACB/ANAPC16/MAPK10/ANAPC10/ANAPC15/PIK3R1/SPDYE1/SPDYE18/CCNB2/CDC27	0.72327546503172
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1391	24/9376	1.40426551641505	EXT1/EXTL3/EXTL2/B3GAT3/XYLT2	0.827621592133653
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	33/1391	200/9376	1.11217828900072	MYO10/MYO1B/LPAR1/HCLS1/ARPC2/RIPK1/IL1B/MYO1D/RPS3/ARPC3/MAPK8/ITGB1/MYH10/ARPC5L/EZR/TUBB6/WIPF1/BRK1/SEC24D/ROCK2/ARPC1A/CASP8/ACTG1/MAPK10/FYN/ARPC5/ACTR3/WASF3/MYO1E/ABI1/ARPC4/SEC24B/ROCK1	0.669281545321884
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1391	168/9376	1.12341241313204	H2AJ/H2AZ1/MACROH2A1/H2AZ2/VDAC3/CHMP5/H2AC20/VDAC1/RIPK1/IL1B/STAT4/JAK1/CHMP2A/MAPK8/VDAC2/H2AX/CAMK2D/JAK2/TNFAIP3/CASP8/MAPK10/HMGB1/STAT2/CHMP6/PLA2G4C/PARP1/IFNG/STAT1	0.673662810526202
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	16/1391	93/9376	1.15965152323307	LAMA2/COL4A4/COL4A2/LAMB1/LAMA4/LAMC3/PTK2/CDK6/ITGB1/CKS1B/PTGS2/PIK3R1/FHIT/COL4A3/MAX/TRAF3	0.645776309133716
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	23/1391	138/9376	1.12341241313204	ELMO1/ARPC2/IL1B/NFATC2/PTK2/ARPC3/MAPK8/ITGB1/ARPC5L/WIPF1/ROCK2/RAC2/ARPC1A/ACTG1/MAPK10/LCK/MAP2K4/ARPC5/GIT2/ACTR3/PIK3R1/ARPC4/ROCK1	0.609566584363982
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1391	31/9376	1.30460796363721	DPYD/ALDH2/HIBCH/ECHS1/HADHA/ALDH7A1	0.708996661692187
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/1391	158/9376	1.10919200283923	WNT11/LAMTOR5/RICTOR/ATP6V1G1/LAMTOR2/RNF152/ATP6V1D/RPS6/SEC13/SOS1/LAMTOR1/PRKCG/LAMTOR4/FZD4/PRKCA/FZD1/EIF4EBP1/SLC38A9/PIK3R1/ATP6V1F/PRR5L/SGK1/LPIN2/WNT2B/STRADB/WNT10A	0.577713833017976
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1391	56/9376	1.20365615692718	GAS1/BOC/SCUBE2/FBXW11/GLI3/PTCH2/PRKACB/CUL3/MOSMO/BTRC	0.637962783842047
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1391	50/9376	1.2132854061826	CD36/VCAM1/CD40/IL1B/TGFB3/KLRB1/ACKR1/ITGAL/IFNG	0.631117437801031
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1391	88/9376	1.14894451343049	C7/A2M/F5/PLAU/CLU/VTN/PROS1/F10/C6/PROCR/C1S/SERPINB2/VWF/CFH/F7	0.585890539878335
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1391	69/9376	1.1722564310943	PPP1CA/CALM1/PPP3CA/CAMK4/PPP3CC/CAMK2D/PRKCG/PRKCA/PRKACB/GNAS/MAOB/CREB5	0.59938638861519
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	8/1391	44/9376	1.22554081432586	ADPRS/MPG/RFC1/APEX1/HMGB1/NTHL1/PARP1/RFC2	0.625858075412946
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1391	63/9376	1.1769082423288	PRDM6/ALDH2/BBOX1/CAMKMT/SMYD3/ECHS1/HADHA/PLOD1/ALDH7A1/TMLHE/SMYD2	0.588010774214577
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1391	32/9376	1.26383896477354	GABARAPL2/ATG7/ATG10/WIPI1/ATG5/ATG3	0.623963594821698
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1391	32/9376	1.26383896477354	SEPTIN4/MAPK8/CASP8/MAPK10/HTRA2/BIRC6	0.623963594821698
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1391	89/9376	1.13603502451555	CD36/LAMA2/VTN/COL6A3/COL4A4/COL4A2/LAMB1/LAMA4/LAMC3/ITGB1/ITGB8/COL9A1/VWF/FREM1/COL4A3	0.538170344664649
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	26/1391	160/9376	1.09532710280374	NEGR1/VCAN/NCAM2/VCAM1/NRXN2/CDH15/PTPRD/ALCAM/CD40/ITGB1/ICAM2/NEO1/ITGB8/SELL/CADM3/PTPRC/NCAM1/ICAM3/NRXN3/CD34/CD2/PTPRS/CD58/ITGAL/PTPRM/SPN	0.507594485552776
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/1391	115/9376	1.11364360953959	PLCB1/GNGT1/GNG5/GNAI1/GNG11/TRPC1/GNAI2/PRKCG/PRKCA/KCNN2/PRKACB/PLCB4/GNAS/PTGS2/GNB1/PLA2G4C/RAPGEF3/GNB2/MAOB	0.511772258295496
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/1391	115/9376	1.11364360953959	PLCB1/PDE4D/PDE4B/GNAI1/AKAP13/NACA/JUND/GNAI2/ADCY3/PRKCG/MMP24/PRKCA/PRKACB/PLCB4/GNAS/STK39/SGK1/RUNX2/CREB5	0.511772258295496
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1391	14/9376	1.44438738831262	CHST2/B4GALT4/B4GALT1	0.694469485012652
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	30/1391	187/9376	1.08135954205223	ANTXR1/PLCB1/TXN/CARD16/GABARAPL2/VDAC3/VDAC1/RIPK1/CYBA/IL1B/JAK1/CARD18/MAPK8/NEK7/VDAC2/GBP1/NAMPT/NLRP1/TANK/TNFAIP3/CASP8/PLCB4/MAPK10/IFI16/ATG5/STAT2/MCU/MAP1LC3B/TRAF3/STAT1	0.469036797472381
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1391	103/9376	1.11250549649969	SLC16A10/COL6A3/COL4A4/COL4A2/COL5A2/KCNQ1/COL15A1/COL14A1/ATP1B1/COL19A1/COL25A1/COL5A3/ATP1B3/COL11A1/SLC8A1/COL9A1/COL4A3	0.479174795315961
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1391	33/9376	1.22554081432586	PDHB/IDH2/IDH3G/ACO1/GOT1/BCKDHB	0.541689830808864
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1391	52/9376	1.16662058286789	APOE/CD36/TSPO/VDAC3/VDAC1/VDAC2/OSBPL5/VAPA/LIPA	0.502852868318049
Human Diseases	Infectious disease: viral	hsa05162	Measles	22/1391	136/9376	1.09037087156933	BAD/RAB9A/IL1B/JAK1/CDK6/MAPK8/RACK1/CBLB/CD3E/CD3D/MSN/TNFAIP3/CASP8/CSNK2A1/MAPK10/IL2RG/CD3G/STAT2/PIK3R1/CCND3/TRAF3/STAT1	0.443071364135732
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	27/1391	169/9376	1.0768805380319	RPS27A/UBB/UBA52/UVRAG/GABARAPL2/BAD/ATG7/ATG10/VAMP8/MAPK8/BNIP3/AMBRA1/WIPI1/EIF2AK3/TANK/PRKACB/MAPK10/PRKCQ/HMGB1/ATG5/PIK3R1/WDR45/RAB7A/MAP1LC3B/VPS41/BIRC6/ATG3	0.42093247960968
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1391	27/9376	1.24823601459115	HMGCLL1/ECHS1/HADHA/HMGCL/OXCT1	0.539108072870761
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/1391	216/9376	1.06100061240248	CD36/PLCB1/HSP90B1/MAP3K5/VCAM1/CD40/RAP1B/RAP1A/CALM1/BAD/CYBA/IL1B/NFATC2/PTK2/CCL3L1/MAPK8/PPP3CA/MMP1/LYN/PPP3CC/CAMK2D/EIF2AK3/ROCK2/TANK/JAK2/CASP8/PRKCA/PLCB4/MAPK10/MAP2K4/HSPD1/PIK3R1/CASP6/TRAF3	0.378551591814808
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/1391	170/9376	1.07054594663171	WNT11/BAD/MGST1/TGFB3/CDK6/GSTT1/LEF1/SOS1/BRD7/GSTA4/GSTP1/MGST2/PRKCG/FZD4/ACTG1/PRKCA/FZD1/PIK3R1/GAB1/NQO1/PBRM1/CDKN2A/SMARCD3/TCF7L1/WNT2B/WNT10A/TXNRD2	0.387411745847803
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/1391	362/9376	1.04272533373582	LAMA2/VTN/HSP90B1/GNGT1/COL6A3/COL4A4/COL4A2/LAMB1/GNG5/LPAR1/EFNA5/LAMA4/KITLG/LAMC3/MAGI2/FGF7/FGFR2/BAD/VEGFC/ANGPT2/JAK1/PTK2/PPP2R5E/GNG11/CDK6/ITGB1/ANGPT1/RPS6/PDGFRA/SOS1/IL7R/ITGB8/C8orf44-SGK3/YWHAB/JAK2/CHRM2/PRKCA/COL9A1/CSF1/IL2RG/GNB1/EIF4EBP1/YWHAH/VWF/PIK3R1/FGFR3/OSMR/IL3RA/CCND3/COL4A3/PPP2R3C/SGK1/FOXO3/GNB2/MTCP1/CREB5	0.34601323839013
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/1391	105/9376	1.09131491561398	PLAU/VCAM1/CD40/RIPK1/IL1B/EDA/CCL4L2/LYN/TNFAIP3/CARD11/CSNK2A1/LCK/PTGS2/PRKCQ/BCL2A1/PARP1/TRAF3	0.392721632189147
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/1391	204/9376	1.05732933000663	CD63/WNT11/PLAU/VTN/ANK3/GPC3/PPP1CA/HCLS1/PTK2/CAV2/ITGB1/RPS6/SOS1/CAMK2D/LUM/EZR/ROCK2/PRKCG/MSN/PDCD4/FZD4/CAV1/ACTG1/PRKCA/PRKACB/FZD1/PIK3R1/GAB1/ESR1/WNT2B/ROCK1/WNT10A	0.345518789845556
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1391	99/9376	1.0893696127341	SLC22A3/SLC44A1/PLPP1/SLC44A2/MAPK8/PDGFRA/SOS1/RAC2/PRKCG/PRKCA/MAPK10/GPCPD1/EIF4EBP1/PIK3R1/PLA2G4C/WASF3	0.37309157145521
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1391	86/9376	1.0972865430592	BAD/PTK2/MAPK8/SOS1/PAK5/CAMK2D/CBLB/PRKCG/PRKCA/MAPK10/MAP2K4/EIF4EBP1/PIK3R1/GAB1	0.378273469866893
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1391	86/9376	1.0972865430592	PLCB1/RYR2/ATP1B1/CAMK2D/ADCY3/ATP1B3/PRKCG/PRKCA/KCNN2/PRKACB/PLCB4/GNAS/GIP/CREB5	0.378273469866893
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1391	139/9376	1.06683768729086	PLCB1/HSP90B1/ESR2/KRT24/KRT10/GNAI1/NCOA1/CALM1/SOS1/GNAI2/ADCY3/PRKACB/PLCB4/GNAS/NCOA3/NCOA2/KRT14/EBAG9/KRT17/PIK3R1/ESR1/CREB5	0.331340928836225
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/1391	133/9376	1.06428544401983	GZMB/CD247/NFATC2/PRF1/CD48/PPP3CA/ICAM2/SOS1/PPP3CC/FCGR3B/RAC2/PRKCG/KLRC1/PRKCA/LCK/FYN/KLRD1/PIK3R1/ITGAL/IFNG/SH2D1B	0.3116332111949
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1391	22/9376	1.22554081432586	ALDH2/ASPA/ALDH7A1/MAOB	0.442027760183731
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/1391	120/9376	1.06724179247544	ARHGDIG/MAP3K5/MAP2K5/RAP1B/RAP1A/CALM1/BAD/IRAK3/BEX3/MAPK8/CAMK4/SOS1/CAMK2D/MATK/MAPK10/PIK3R1/GAB1/ARHGDIB/FOXO3	0.309406886061591
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1391	61/9376	1.10499581619545	MT2A/ATP2B1/ATOX1/ATP1B1/MT1E/SLC39A4/ATP1B3/SLC8A1/STEAP1/ATP2B3	0.343365949034438
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/1391	140/9376	1.05921741809592	PLCB1/GNGT1/CCN2/GNG5/RYR2/GNAI1/PDE3B/CALM1/GNG11/NOTCH3/RPS6/CAMK4/GNAI2/ADCY3/SLC8A1/PRKCE/PRKACB/PLCB4/GNB1/NRF1/MAP1LC3B/GNB2	0.294634274668544
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1391	55/9376	1.10298673289327	CERS4/PLPP1/B4GALT6/CERS6/CERS5/SGMS1/ACER3/DEGS1/B4GALT5	0.319700352197137
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/1391	194/9376	1.04234141424622	MYL12A/MYL6/MYL9/MYL12B/MYO10/MYO1B/DYNLT1/DCTN3/KIF13A/MYO1D/DYNLT3/DYNC1I2/MYH10/TUBB6/ACTR10/DYNLL1/ACTG1/KIFAP3/MYL6B/DCTN2/CAPZA2/TNNI3/DNAI4/MYO16/MYL10/DYNC1LI1/MYO1E/TUBG2/KIF2A/DCTN6	0.24871920651304
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1391	42/9376	1.12341241313204	VDAC3/ATG7/GSS/VDAC2/PRNP/ATG5/MAP1LC3B	0.334550231096771
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1391	254/9376	1.03495474280668	PLCB1/HRH2/ATP2B1/RYR2/FGF7/VDAC3/VDAC1/CALM1/FGFR2/VEGFC/NFATC2/MST1R/PPP3CA/CAMK4/VDAC2/P2RX1/PDGFRA/CAMK1D/PPP3CC/CAMK2D/CXCR4/ADCY3/SLC8A1/PRKCG/CHRM2/PRKCA/PRKACB/PLCB4/GNAS/TACR1/PLCD1/ATP2B3/PTGFR/FGFR3/ATP2A3/MCU/CD38/STIM2/ORAI1	0.23571633412438
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	17/1391	108/9376	1.06100061240248	SUMO2/SUMO1/MAGOH/THOC7/MAGOHB/UPF3A/SEC13/SAP18/ALYREF/SNUPN/KPNA3/NUP37/PNN/NUP107/RANBP17/NUP54/NUP88	0.266112210908431
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1391	75/9376	1.07847591660676	MAP3K5/ERCC1/BAD/MGST1/GSTT1/GSTA4/GSTP1/MGST2/CASP8/PIK3R1/CDKN2A/MSH3	0.2847829270549
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1391	155/9376	1.04368637090977	WNT11/PLCB1/HSD3B2/MRAP/GNAI1/RAP1B/RAP1A/CDK6/LEF1/CAMK2D/GNAI2/ADCY3/FZD4/PRKACB/PLCB4/GNAS/FH/FZD1/CDKN2A/TCF7L1/WNT2B/WNT10A/CREB5/ORAI1	0.228894074370787
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/1391	122/9376	1.04974602538568	PLCB1/SSTR1/GNAI1/PTK2/MAPK8/SOS1/GNAI2/ADCY3/JAK2/PRKCG/PRKCA/PRKACB/PLCB4/GNAS/MAPK10/MAP2K4/PIK3R1/CREB5/STAT1	0.230826304095413
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/1391	142/9376	1.04429886291147	CYBA/IL1B/NFATC2/FHL2/JAK1/MAPK8/PPP3CA/CAMK4/PPP3CC/JUND/FCGR3B/GAB2/CSF1/MAPK10/LCK/FYN/STAT2/PIK3R1/ATP2A3/TNFRSF11B/IFNG/STAT1	0.22200029864802
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/1391	69/9376	1.07456839516978	MAPK8/LYN/SOS1/RAC2/PRKCA/GAB2/MAPK10/MAP2K4/FYN/PIK3R1/PLA2G4C	0.25946944797187
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1391	23/9376	1.1722564310943	LARGE1/CRPPA/RXYLT1/B4GALT1	0.345203856460373
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1391	23/9376	1.1722564310943	RPA3/RFC1/MSH3/RFC2	0.345203856460373
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	30/1391	196/9376	1.03170527736616	GNGT1/RPS27A/UBB/UBA52/GNG5/CALM1/ANGPT2/NFATC2/JAK1/GNG11/CDK6/MAPK8/PPP3CA/LYN/LEF1/PPP3CC/JAK2/CASP8/MAPK10/PTGS2/MAP2K4/GNB1/STAT2/PIK3R1/MAP1LC3B/TCF7L1/GNB2/ATG3/TRAF3/STAT1	0.187219031771024
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1391	63/9376	1.06991658393528	WNT11/BMP4/LEF1/GLI3/PTCH2/FZD4/FZD1/TCF7L1/WNT2B/WNT10A	0.23238998991245
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1391	30/9376	1.12341241313204	PIGP/PIGF/PIGL/PIGC/PIGK	0.282564973635531
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1391	37/9376	1.09304991547982	UXS1/HK1/PMM1/GMDS/PMM2/PGM1	0.236689177391035
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	16/1391	104/9376	1.03699607366034	PLA2G2A/GPAT2/PLPP1/TAFAZZIN/CHAT/PLA2G5/AGPAT4/PLAAT2/GPCPD1/SGMS1/PLA2G4C/PLPP5/PEMT/CDIPT/MBOAT2/LPIN2	0.158342441320689
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/1391	333/9376	1.01208325507391	LAMA2/WNT11/VTN/COL6A3/COL4A4/COL4A2/LAMB1/PARD3/LAMA4/MAML2/LAMC3/MAML3/BAD/JAK1/ATP6V1G1/PTK2/PALS1/PPP2R5E/NOTCH3/ATP6V1D/CDK6/ITGB1/SOS1/PTGER4/ITGB8/DLG1/FZD4/CASP8/PRKACB/GNAS/COL9A1/PTGS2/FZD1/EIF4EBP1/VWF/TCIRG1/STAT2/PIK3R1/ATP6V1F/TUBG2/CCND3/COL4A3/PPP2R3C/TCF7L1/WNT2B/PARD6G/TRAF3/WNT10A/CREB5/STAT1	0.0937047351930825
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	15/1391	98/9376	1.03170527736616	PLCB1/BPNT2/CALM1/IMPA2/PRKCG/PIP4K2A/PRKCA/PLCB4/IP6K2/IPMK/PLCD1/PIK3R1/INPP4B/CDIPT/INPP5A	0.131682830658218
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1391	51/9376	1.05732933000663	PLA2G2A/PEDS1/ENPP2/PLPP1/PLA2G5/PLAAT2/PLA2G4C/PAFAH1B3	0.171336257781365
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/1391	112/9376	1.02310773338811	LAMA2/LAMB1/LAMA4/LAMC3/GNAI1/CD40/BAD/JAK1/TGFB3/MAPK8/ITGB1/GNAI2/JAK2/CASP8/MAPK10/IFNG/STAT1	0.102678337727191
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1391	38/9376	1.06428544401983	UXS1/HK1/PMM1/PMM2/GNPDA2/PGM1	0.165725468105997
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1391	38/9376	1.06428544401983	QPRT/BST1/NAMPT/NT5C2/NT5C/CD38	0.165725468105997
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	10/1391	65/9376	1.03699607366034	AKR1B1/ALDH2/GPAT2/PLPP1/AKR1A1/AGPAT4/PLPP5/ALDH7A1/MBOAT2/LPIN2	0.124918250553937
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/1391	119/9376	1.01956756822067	MAP3K5/VCAM1/VEGFC/RIPK1/IL1B/MAP3K8/MAPK8/TNFAIP3/CASP8/CSF1/MAPK10/PTGS2/MAP2K4/IL15/PIK3R1/TRAF3/CREB5/CEBPB	0.0896575667924018
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/1391	99/9376	1.02128401193822	ESR2/NCOR1/BAD/PTK2/NOTCH3/MAPK8/SOS1/ADCY3/PRKACB/GNAS/MAPK10/NCOA3/PIK3R1/ESR1/CDKN2A	0.0888544239810855
NA	NA	hsa04519	Cadherin signaling	60/1391	404/9376	1.00106056615726	VIM/WNT11/DES/LHFPL6/MYO1B/KRT24/STK3/ENAH/KRT10/PPP1CA/CDH15/KRT6A/PKP1/FAT3/ARPC2/PRICKLE1/CDH11/MYO1D/TAOK3/TMC7/PTK2/PALS1/ARPC3/CTNND2/MAPK8/LEF1/PDGFRA/ARPC5L/BRK1/ROCK2/YWHAB/RAC2/WWC1/ARPC1A/FZD4/YAP1/ACTG1/KRT5/DAAM1/MAPK10/KRT14/WTIP/FZD1/KRT17/ARPC5/YWHAH/ACTR3/DAAM2/LATS2/MYO1E/TEAD2/EVL/ARPC4/PCDHB2/TCF7L1/SHOC2/WNT2B/ROCK1/WNT10A/GABRG2	0.00909485035582808
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1391	100/9376	1.01107117181884	CD36/CD7/KITLG/IL1B/IL7R/CD3E/CD3D/CSF1/CD3G/CD9/CD34/CD2/IL3RA/CD38/CD37	0.0464541976941353
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1391	32/9376	1.05319913731129	AKR1B1/GALM/HK1/PGM1/B4GALT1	0.125812822934075
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1391	73/9376	1.01568793516047	BAD/EML4/CDK6/SOS1/PRKCG/PRKCA/ALK/PIK3R1/FHIT/CDKN2A/FOXO3	0.056160045144188
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1391	39/9376	1.03699607366034	GCSH/MTHFD1L/AHCYL2/DHFR/ST20-MTHFS/ALDH7A1	0.0966264452016681
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	14/1391	94/9376	1.00390045428821	HSP90B1/S100A8/IL1B/MAPK8/MMP1/JUND/TNFAIP3/CASP8/S100A9/MAPK10/PTGS2/IFNG/TRAF3/CEBPB	0.0158624432085045
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1391	12/9376	1.12341241313204	NCAM2/NCAM1	0.178537935187587
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1391	19/9376	1.06428544401983	PDHB/GCSH/BCKDHB	0.117066565342358
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/1391	205/9376	0.986410899335449	VIM/PDIA3/SEM1/CALR/CD247/CD40/RIPK1/JAK1/CDK6/MAPK8/LYN/CIR1/CD3E/RUNX3/CD3D/TNFAIP3/CASP8/PSMD8/MAPK10/MAP2K4/CD3G/STAT2/PIK3R1/SNW1/NEDD4/CD58/ITGAL/CCND3/TRAF3/STAT1	-0.0821052716949371
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/1391	110/9376	0.980432651460689	TIMP1/ELOB/PDHB/RBX1/ANGPT2/LDHB/ELOC/ANGPT1/RPS6/HK1/CAMK2D/PRKCG/PRKCA/EIF4EBP1/PIK3R1/IFNG	-0.08615766460989
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1391	41/9376	0.986410899335449	GRHPR/GCSH/PHGDH/SRR/ALDH7A1/MAOB	-0.0363946230792532
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1391	76/9376	0.975594990351508	CD36/MMP1/SCD5/SCP2/ILK/FADS2/DBI/ME3/ACAA1/ACOX2/ACADM	-0.0891571235485879
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1391	76/9376	0.975594990351508	CALM1/CDK6/CAMK4/PDGFRA/CAMK1D/SOS1/CAMK2D/PRKCG/PRKCA/PIK3R1/CDKN2A	-0.0891571235485879
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1391	13/9376	1.03699607366034	XRCC4/XRCC5	0.0557097927597681
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/1391	77/9376	0.962924925541748	RALA/BAD/JAK1/TGFB3/CDK6/MAPK8/RAC2/MAPK10/PIK3R1/CDKN2A/STAT1	-0.136339285463816
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/1391	243/9376	0.970850233570898	U2AF1/SF3B6/SNRPF/SNRPB2/LSM7/SNRPD1/LSM6/LSM5/LSM3/SNRPE/MAGOH/THOC7/SNRPD2/BUD31/MAGOHB/SNRPG/CWC15/ALYREF/PHF5A/RBMX2/SRSF10/TXNL4A/HNRNPA1/ZMAT2/RP9/DDX46/SRSF9/PPIH/SF3A3/SNW1/PPIL1/CRNKL1/PRPF18/BCAS2/CDC40	-0.192151257128323
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1391	35/9376	0.962924925541748	AKR1B1/HK1/PMM1/GMDS/PMM2	-0.0917130446051987
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1391	28/9376	0.962924925541748	ST3GAL4/ST8SIA1/B4GALT4/B4GALT1	-0.081999921885747
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1391	28/9376	0.962924925541748	ATP6V1G1/ATP6V1D/TCIRG1/ATP6V1F	-0.081999921885747
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/1391	155/9376	0.956712506667285	CD36/SEC61G/COLEC11/SEC61B/CALR/MRC2/CYBA/ATP6V1G1/DYNC1I2/STX18/ATP6V1D/ITGB1/FCGR3B/TUBB6/ACTG1/TCIRG1/CORO1A/PLA2R1/ATP6V1F/DYNC1LI1/RAB7A/STX12	-0.226804161386831
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1391	43/9376	0.940531322622172	ALDH2/ECHS1/HADHA/ALDH7A1/ACAA1/ACADM	-0.163126161675498
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1391	36/9376	0.936177010943366	AKR1B1/AKR1A1/GUSB/CRPPA/FGGY	-0.160127784589144
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/1391	93/9376	0.942216862626872	PLCB1/CALM1/MAPK8/SOS1/CAMK2D/ADCY3/PRKCA/PRKACB/PLCB4/GNAS/MAPK10/MAP2K4/PLA2G4C	-0.233727686572146
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/1391	72/9376	0.936177010943366	RIPK1/MAPK8/PIN1/TANK/CASP8/MAPK10/RNF125/ATG5/AZI2/TRAF3	-0.226892573042018
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1391	65/9376	0.93329646629431	PLCB1/HSD3B2/MRAP/ADCY3/PRKACB/PLCB4/GNAS/CREB5/ORAI1	-0.225226298681852
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/1391	157/9376	0.944525086200186	PPP1CA/VDAC3/VDAC1/CALM1/ETS1/NFATC2/TGFB3/FBXW11/CDK6/PPP3CA/VDAC2/PPP3CC/EIF4EBP1/PIK3R1/MCU/CCND3/CDKN2A/FOXO3/CCNB2/LIN52/HIPK1/BTRC	-0.292560909702461
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	6/1391	44/9376	0.919155610744396	GTF2A2/MNAT1/GTF2H5/CCNH/TAF11/TAF12	-0.224336841288268
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1391	37/9376	0.910874929566518	ADSS2/ASPA/CPS1/NIT2/GOT1	-0.226705628877151
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	22/1391	158/9376	0.938547079325501	STAG1/RBX1/ANAPC11/PPP2R5E/TGFB3/CDC26/CDK6/TFDP2/CDKN2D/CCNH/YWHAB/ANAPC16/ANAPC10/YWHAH/ANAPC15/SFN/CCND3/CDC14A/CDKN2A/CCNB2/CDC27/ORC3	-0.32513555416038
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1391	109/9376	0.927588231026454	CD40/RIPK1/IL1B/JAK1/MAP3K8/CCL3L1/CCL4L2/MAPK8/CASP8/MAPK10/MAP2K4/STAT2/PIK3R1/TRAF3/STAT1	-0.317369046867972
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1391	95/9376	0.922380718150516	IL1B/ATP6V1G1/TGFB3/CCL3L1/ATP6V1D/ANGPT1/MMP1/CSF1/IL15/TCIRG1/ATP6V1F/ITGAL/IFNG	-0.317355317425364
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1391	52/9376	0.907371564452801	HSD3B2/ADCY3/HSD17B2/PRKACB/GNAS/PTGS2/PLA2G4C	-0.279548142858523
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1391	30/9376	0.898729930505631	PLA2G2A/PLA2G5/PLAAT2/PLA2G4C	-0.231867879336652
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1391	45/9376	0.898729930505631	GZMB/IL1B/PRF1/KLRC1/KLRD1/IFNG	-0.284207158870511
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1391	23/9376	0.879192323320726	ATP1B1/MDH1/ATP1B3	-0.242099964656023
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1391	82/9376	0.904209991057495	NME3/DPYD/MGST1/GSTT1/NME7/GSTA4/GUSB/GSTP1/MGST2/DUT/NME1	-0.363611448603612
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1391	31/9376	0.869738642424805	ALDH2/AKR1A1/GUSB/ALDH7A1	-0.303192557953941
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1391	16/9376	0.842559309849029	GOT1/MAOB	-0.263057564411104
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/1391	149/9376	0.904761675005669	PLCB1/LPAR1/KITLG/RALA/PLPP1/PDGFRA/SOS1/ADCY3/AGPAT4/PRKCA/PLCB4/DNM3/GNAS/GAB2/FYN/PTGFR/PIK3R1/GAB1/PLA2G4C/RAPGEF3	-0.489087277183133
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1391	70/9376	0.866632432987573	HSD11B1/SULT1A1/MGST1/GSTT1/GSTA4/GSTP1/MGST2/GSTK1/PTGS2	-0.467443868414095
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/1391	157/9376	0.901592127736541	CD36/PROS1/MFGE8/CALR/ELMO1/ANO6/NFATC2/PTK2/PTGER4/CAMK2D/JAK2/CX3CR1/PTGS2/VPS8/ATP2A3/RAB7A/LIPA/SGK1/TYRO3/VPS41/CEBPB	-0.51897866367442
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1391	107/9376	0.881931240215806	PLCB1/PDHB/SIK1/PDE3B/CALM1/LDHB/PPP3CA/PPP3CC/CAMK2D/PRKACB/PLCB4/GNAS/PRMT1/CREB5	-0.512651452352345
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1391	48/9376	0.842559309849029	PLCB1/ATP1B1/HK1/ATP1B3/PLCB4/PIK3R1	-0.456409922747071
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1391	63/9376	0.85593326714822	PLA2G2A/PTGR3/PLA2G5/PLAAT2/GGT5/PTGS2/PLA2G4C/EPHX2	-0.478851578691804
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	34/1391	250/9376	0.916704529115744	CD63/OSBPL1A/SUMF1/CTSW/AP1S2/NAGLU/LAMTOR5/VPS29/AP2S1/ATP6V1G1/LAMTOR2/VAMP8/ATP6V1D/LITAF/GUSB/LAMTOR1/LAMTOR4/ARSG/AP1S1/HYAL2/ARSB/OSBPL5/AP3B1/TCIRG1/SLC38A9/ATP6V1F/AP3M1/CTBS/CLTCL1/RAB7A/HGSNAT/LIPA/VPS41/AP3B2	-0.557138156402845
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1391	78/9376	0.864163394716953	PLCB1/IMPA2/PIP4K2A/PLCB4/IP6K2/IPMK/PLCD1/INPP4B/CDIPT/INPP5A	-0.502783587998954
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1391	78/9376	0.864163394716953	CYBA/IL1B/JAK1/TGFB3/ITGB1/FCGR3B/JAK2/PTGS2/IFNG/STAT1	-0.502783587998954
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1391	17/9376	0.792996997504969	SCP2/ACOX2	-0.356531679326774
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1391	17/9376	0.792996997504969	GGT5/CDO1	-0.356531679326774
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1391	17/9376	0.792996997504969	CPS1/CA8	-0.356531679326774
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	41/1391	300/9376	0.921198178768272	CACNB2/MAP3K5/MAP2K5/STK3/EFNA5/KITLG/FGF7/RAP1B/RAP1A/FGFR2/VEGFC/CACNA2D1/ANGPT2/IL1B/TAOK3/MAP3K8/TGFB3/MAPK8/PPP3CA/MAP3K13/ANGPT1/PDGFRA/SOS1/PPP3CC/JUND/RAC2/PRKCG/RASA2/MAP4K4/RASGRP1/PRKCA/PRKACB/CSF1/MAPK10/MAP2K4/RASA1/FGFR3/PLA2G4C/MAP4K3/MAX/NF1	-0.578977093207615
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1391	71/9376	0.854426342382114	ESR2/MAPK8/SOS1/JAK2/MAPK10/PIK3R1/ESR1/FOXO3/STAT1	-0.513884504853963
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1391	144/9376	0.889368160396198	WNT11/ID4/BMP4/ID1/ID3/FGFR2/JAK1/JARID2/JAK2/FZD4/ACVR1/PCGF5/ID2/FZD1/PIK3R1/FGFR3/SMAD9/WNT2B/WNT10A	-0.558374048050816
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1391	41/9376	0.822009082779541	RAD51B/SEM1/BABAM2/RPA3/UIMC1	-0.476699121132259
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/1391	137/9376	0.885609785534746	MAP3K5/GZMB/CTSW/SEPTIN4/BAD/RIPK1/PRF1/MAPK8/EIF2AK3/CASP8/ACTG1/MAPK10/PIK3R1/CASP6/IL3RA/HTRA2/BCL2A1/PARP1	-0.562922253037081
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	26/1391	195/9376	0.898729930505631	H3-3B/H3-3A/H2AJ/H4C3/H2AZ1/PLCB1/MACROH2A1/H2AZ2/VDAC3/H2AC20/VDAC1/ATG7/CYBA/VDAC2/H2AX/FCGR3B/RAC2/PRKCG/ACTG1/PRKCA/PLCB4/HMGB1/VWF/CLCN5/PIK3R1/ITGAL	-0.596437804577783
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1391	49/9376	0.825364221892927	GNAI1/GNAI2/PRKACB/GNAS/MAOB/CREB5	-0.511531070718391
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/1391	87/9376	0.852243899617409	RALA/BAD/TGFB3/MAPK8/LEF1/SOS1/RAC2/MAPK10/PIK3R1/TCF7L1/MSH3	-0.577872873632482
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1391	65/9376	0.829596858928275	PLCB1/ESR2/TRPC1/PRKCG/PRKCA/KCNN2/PLCB4/PIK3R1	-0.575370847917641
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1391	18/9376	0.748941608754693	CBR4/MECR	-0.444970496875207
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1391	50/9376	0.808856937455068	ALDH2/ALDH7A1/P4HA3/P4HA2/GOT1/MAOB	-0.565597628294924
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/1391	103/9376	0.850739497323292	PPP1CA/MAGOH/MAGOHB/PPP2R5E/UPF3A/SAP18/RNGTT/ALYREF/PNN/CSTF2T/SMG6/PPP2R3C/CPSF6	-0.635718903023254
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1391	66/9376	0.817027209550574	RORA/IL1B/STAT4/TGFB3/IL2RG/IFNG/TBX21/STAT1	-0.622580310364989
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/1391	163/9376	0.86840468745176	VDAC3/BAD/NFATC2/STAT4/JAK1/TGFB3/MAPK8/SOS1/YWHAB/JAK2/PRKCG/CASP8/PRKCA/MAPK10/MAP2K4/STAT2/PIK3R1/TRAF3/CREB5/SLC10A1/STAT1	-0.707368032931841
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/1391	59/9376	0.799717311043147	BAD/LEF1/SOS1/ILK/PIK3R1/FOXO3/TCF7L1	-0.644084895446475
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1391	67/9376	0.804832773587133	ALDH2/PDHB/GALM/LDHB/HK1/AKR1A1/PGM1/ALDH7A1	-0.669120783112416
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1391	105/9376	0.834534935469515	CALM1/IL1B/NFATC2/MAPK8/PPP3CA/PPP3CC/CBLB/CASP8/MAPK10/PTGS2/STAT2/PIK3R1/STAT1	-0.711622080311549
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/1391	75/9376	0.808856937455068	COP1/CDK6/SESN1/CASP8/GORAB/SFN/CCND3/CDKN2A/CCNB2	-0.693643135263437
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1391	44/9376	0.765963008953663	GZMB/IL1B/PRF1/HSPD1/IFNG	-0.649434299638875
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1391	36/9376	0.748941608754693	PRIM2/RPA3/RFC1/RFC2	-0.629889395448912
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/1391	68/9376	0.792996997504969	BAD/LEF1/SOS1/RUNX1T1/EIF4EBP1/PIK3R1/BCL2A1/TCF7L1	-0.715014183385833
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1391	20/9376	0.674047447879224	CYB5R2/GMDS	-0.60902626150104
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1391	37/9376	0.728699943653215	GSTZ1/GOT1/FAH/MAOB	-0.690100435145337
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1391	29/9376	0.697290463323335	GNGT1/CALM1/GNB1	-0.681397795086377
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1391	46/9376	0.732660269433939	EPRS1/GUSB/MMAB/BLVRA/UROS	-0.758600881369189
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/1391	62/9376	0.761021312121704	SOD1/ADCY3/PRKACB/ATG5/PIK3R1/CAT/FOXO3	-0.78794996977257
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/1391	62/9376	0.761021312121704	MAML2/MAML3/NOTCH3/NUMB/CIR1/ATXN1/SNW1	-0.78794996977257
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1391	78/9376	0.777747055245258	GNAI1/CALM1/IL1B/MAPK8/ITGB1/CFL1/GNAI2/C1S/MAPK10	-0.82264374006017
Human Diseases	Substance dependence	hsa05034	Alcoholism	24/1391	191/9376	0.846970615136197	H3-3B/H3-3A/H2AJ/H4C3/H2AZ1/GNGT1/MACROH2A1/H2AZ2/GNG5/PPP1CA/GNAI1/H2AC20/CALM1/GNG11/CAMK4/SOS1/H2AX/GNAI2/PRKACB/GNAS/GNB1/GNB2/MAOB/CREB5	-0.891792219031519
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1391	30/9376	0.674047447879224	IL1B/ABCC3/DHFR	-0.746300732308834
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1391	71/9376	0.759490082117435	ATP6V1G1/ATP6V1D/MAPK8/LYN/MAPK10/MAP2K4/TCIRG1/ATP6V1F	-0.849015694776113
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1391	71/9376	0.759490082117435	PDHB/FGFR2/LDHB/PDGFRA/HK1/IDH2/PIK3R1/FGFR3	-0.849015694776113
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1391	47/9376	0.717071753063004	MAPK8/HK1/PRKCE/MAPK10/PIK3R1	-0.811557758603701
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1391	39/9376	0.691330715773563	GZMB/CD40/PRF1/IFNG	-0.806183271002456
NA	NA	hsa04981	Folate transport and metabolism	3/1391	31/9376	0.652303981818603	ABCC3/DHFR/ST20-MTHFS	-0.809287167777006
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/1391	73/9376	0.738682134662163	SERINC5/MAP1B/APOBEC3G/PIN1/CXCR4/CHMP6/MDFIC/CPSF6	-0.935471938418729
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	17/1391	143/9376	0.801315147828448	H3-3B/C7/H3-3A/H2AJ/H4C3/H2AZ1/MACROH2A1/H2AZ2/C6/SNRPD1/CD40/H2AC20/SSB/H2AX/FCGR3B/C1S/IFNG	-0.999247571518543
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/1391	181/9376	0.819284190792426	MRC2/CALM1/BAD/IL1B/JAK1/TGFB3/MAPK8/PPP3CA/PPP3CC/FCGR3B/CAMK2D/JAK2/CASP8/MAPK10/TCIRG1/CORO1A/PLA2R1/HSPD1/RAB7A/IFNG/STAT1/CEBPB	-1.02464001052335
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1391	23/9376	0.586128215547151	CPS1/GOT1	-0.82940378577242
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1391	23/9376	0.586128215547151	PDSS2/FDPS	-0.82940378577242
NA	NA	hsa04081	Hormone signaling	27/1391	219/9376	0.831017401494933	SLC16A10/PLCB1/GNGT1/PRKG1/ESR2/SSTR1/GNG5/GNAI1/NPR3/GNG11/GNAI2/ADCY3/JAK2/RAMP2/ACVR1/PRKACB/PLCB4/GNAS/GNB1/PENK/GIP/PIK3R1/ESR1/SMAD9/RAPGEF3/DIO1/GNB2	-1.05608573731199
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/1391	90/9376	0.748941608754693	CAMK4/ADCY3/SESN1/PRKACB/EIF4EBP1/ATG5/PIK3R1/CAT/FOXO3/CREB5	-0.998834189555191
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1391	90/9376	0.748941608754693	CFTR/ATP1B1/ABCC3/ADCY3/ATP1B3/KCNN2/PRKACB/GNAS/SCT/SLC10A1	-0.998834189555191
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/1391	83/9376	0.730894823001568	POLR2L/POLR1D/POLR2K/RIPK1/IL1B/CCL4L2/CASP8/IFI16/POLR2F	-1.02776748334939
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/1391	75/9376	0.718983944404505	PHGDH/IDH2/CPS1/IDH3G/TALDO1/ACO1/GOT1/RPIA	-1.01978515603622
NA	NA	hsa04082	Neuroactive ligand signaling	24/1391	199/9376	0.812921545180973	PLCB1/GNGT1/HRH2/GNG5/GNAI1/GRIK1/GNG11/GLRB/P2RX1/GNAI2/ADCY3/CHAT/PRKCG/CHRM2/PRKCA/PRKACB/PLCB4/GNAS/TACR1/GNB1/PENK/GRIK2/GNB2/GABRG2	-1.113298668084
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1391	43/9376	0.627020881748115	CD36/PLA2G2A/PLPP1/PLA2G5	-1.02310417228527
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/1391	133/9376	0.76020388858559	GABARAPL2/TGFB3/MAPK8/CDKN2D/SOS1/BNIP3/IL7R/C8orf44-SGK3/PRMT1/MAPK10/PIK3R1/CAT/SGK1/FOXO3/CCNB2	-1.16244716625236
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1391	15/9376	0.449364965252816	ST8SIA1	-0.890758735846862
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1391	79/9376	0.68257969405491	HSD11B1/MGST1/GSTT1/GSTA4/GSTP1/MGST2/AKR7A2/GSTK1	-1.18246577377113
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1391	45/9376	0.599153287003754	CFTR/ABCC3/ABCD3/ABCB7	-1.12494744016722
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	24/1391	205/9376	0.789128719468359	H4C3/GSN/VDAC3/GTF2A2/BAD/JAK1/CDK6/LYN/RANBP1/DLG1/YWHAB/RASA2/CASP8/PRKACB/YWHAH/PIK3R1/SND1/SNW1/REL/SP100/CCND3/CDKN2A/TRAF3/CREB5	-1.27408312059052
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1391	36/9376	0.56170620656602	HK1/AGL/PGM1	-1.09965100630868
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1391	144/9376	0.748941608754693	MAP3K5/ALDH2/RIPK1/IL1B/MAPK8/LEF1/SCD5/CASP8/MAPK10/MAP2K4/ALDH7A1/FOXO3/TCF7L1/LPIN2/ACADM/TRAF3	-1.26712608882579
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1391	16/9376	0.421279654924515	ST8SIA1	-0.966946755027119
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/1391	168/9376	0.762315566053884	CNTFR/STAT4/JAK1/PTPN2/PDGFRA/SOS1/IL7R/JAK2/IL2RG/IL15/STAT2/PIK3R1/OSMR/STAM/IL3RA/CCND3/PIAS1/IFNG/STAT1	-1.29743159319929
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/1391	37/9376	0.546524957739911	LEF1/TFG/TCF7L1	-1.15349524141352
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/1391	138/9376	0.732660269433939	PPP1CA/PDE3B/CALM1/BAD/MAPK8/RPS6/SOS1/HK1/CBLB/PRKACB/MAPK10/EIF4EBP1/PRKAR1B/PIK3R1/INPP5A	-1.3204617128067
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	11/1391	106/9376	0.699483200629383	PLAU/HSP90B1/FGFR2/BAD/LEF1/PDGFRA/SOS1/GSTP1/PIK3R1/TCF7L1/CREB5	-1.29865431624748
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1391	73/9376	0.646346867829392	MGST1/GSTT1/GSTA4/GSTP1/MGST2/GSTK1/MAOB	-1.2660159329397
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1391	201/9376	0.771298074687669	H3-3B/H3-3A/PLAU/CDK14/GZMB/BCL11B/NCOR1/SUPT3H/CD40/PTK2/MLF1/KDM6A/RUNX1T1/ID2/ETV6/PBX3/JMJD1C/REL/MAX/BCL2A1/SLC45A3/RUNX2/CEBPB	-1.36796994529008
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1391	56/9376	0.601828078463592	IL1B/BNIP3/CASP8/HSPD1/SAR1B	-1.24729284566597
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1391	17/9376	0.396498498752484	MYH10	-1.03944097970836
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	25/1391	217/9376	0.776552359307861	HSP90B1/ESR2/GNAI1/FGF7/BAD/MGST1/PAQR8/GSTT1/SOS1/GNAI2/ADCY3/GSTA4/JAK2/MGST2/PRKCG/PRKCA/PRKACB/GNAS/EIF4EBP1/KPNA3/PIK3R1/EPHX2/ESR1/CCND3/CREB5	-1.38993136040177
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1391	91/9376	0.666640333067364	IFITM1/NFATC2/PPP3CA/LYN/SOS1/PPP3CC/RAC2/CARD11/PIK3R1	-1.33368890604237
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/1391	148/9376	0.728699943653215	WNT11/ESR2/NCOA1/FGF7/NOTCH3/CDK6/LEF1/SOS1/FZD4/NCOA3/FZD1/PIK3R1/ESR1/TCF7L1/WNT2B/WNT10A	-1.38847700510517
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/1391	83/9376	0.649684287112505	L3MBTL4/SCMH1/MBD5/UBE2D2/JARID2/PCGF5/AEBP2/MAX	-1.33792706118852
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1391	66/9376	0.612770407162931	HSD3B2/HSD11B1/HSD17B2/HSD17B6/HSD17B11/HSD17B12	-1.31758126166659
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1391	18/9376	0.374470804377346	MMAB	-1.10867450239572
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1391	49/9376	0.550242814595284	B3GLCT/POFUT2/GALNT12/B4GALT1	-1.31739771258273
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/1391	77/9376	0.612770407162931	BAD/TGFB3/CDK6/SOS1/GAB2/PIK3R1/CDKN2A	-1.42399190748219
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/1391	41/9376	0.493205449667725	MMP1/FGFR3/CDKN2A	-1.35730811723827
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1391	79/9376	0.597257232298046	AP2S1/ATP6V1G1/ATP6V1D/DNM3/TCIRG1/ATP6V1F/CLTCL1	-1.50031213984086
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/1391	122/9376	0.662997489717269	CD36/CFTR/RAB2A/PPP2R5E/SCD5/EIF4EBP1/PIK3R1/PPP2R3C/RAB11B/FOXO3/STRADB/CREB5	-1.56372380137606
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/1391	180/9376	0.711494528316958	PDIA3/CALR/PPP1CA/BAD/IL1B/JAK1/JAK2/ALYREF/CASP8/EIF4EBP1/SRSF9/STAT2/EIF2B3/PIK3R1/SP100/SRPK1/IFNG/TRAF3/STAT1	-1.63118255610656
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/1391	73/9376	0.554011600996622	FGF7/BAD/CDK6/PDGFRA/PIK3R1/CDKN2A	-1.59655992746067
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/1391	100/9376	0.606642703091301	XCL1/CCL3L1/CCL4L2/CXCR4/XCL2/CXCL14/CX3CR1/CSF1/IL2RG	-1.65051161105993
NA	NA	hsa04382	Cornified envelope formation	23/1391	217/9376	0.714428170563232	S100A4/S100A8/COL4A4/S100A10/COL4A2/S100A11/KRT24/S100A6/KRT10/KRT6A/PKP1/SPRR3/KAZN/PPP2R5E/S100A12/S100A9/KRT5/KRT14/KRT17/EPHX2/ELOVL1/COL4A3/PPP2R3C	-1.77636801244343
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/1391	36/9376	0.374470804377346	B4GALT5/GALNT12	-1.56941261716845
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/1391	156/9376	0.648122546037715	BAD/RIPK1/JAK1/EIF3E/CDK6/SOS1/YWHAB/CASP8/YWHAH/STAT2/PIK3R1/PIAS1/IFNG/TRAF3/STAT1	-1.84969457386744
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1391	68/9376	0.495623123440606	PNPLA4/DHRS4/DHRS4L2/ALDH1A2/HSD17B6	-1.74218062619874
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/1391	173/9376	0.662358763811954	VDAC1/IL1B/JAK1/CDK6/JAK2/CASP8/RAB11A/ACTG1/PRKCA/STAT2/PIK3R1/CCND3/RAB11B/IFNG/FDPS/TRAF3/STAT1	-1.87079226314238
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1391	48/9376	0.421279654924515	CD63/CD9/SLC10A1	-1.67767117722097
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/1391	70/9376	0.481462462770874	CD36/MAPK8/JAK2/MAPK10/PRKCQ	-1.81743731065976
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1391	50/9376	0.404428468727534	CD40/CXCR4/IL15	-1.76231269439088
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1391	99/9376	0.544684806367049	KRT24/KRT10/FCGR3B/C1S/KRT14/KRT17/CFH/ITGAL	-1.90080560833779
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/1391	54/9376	0.374470804377346	ERCC1/RPA3/FANCC	-1.92398489496622
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1391	54/9376	0.374470804377346	GZMB/CD40/PRF1	-1.92398489496622
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/1391	150/9376	0.58417445482866	WNT11/FGF7/FGFR2/TGFB3/LEF1/SOS1/FZD4/FZD1/PIK3R1/GAB1/TCF7L1/WNT2B/WNT10A	-2.14270218721427
Human Diseases	Immune disease	hsa05310	Asthma	1/1391	32/9376	0.210639827462257	CD40	-1.86679026461642
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/1391	109/9376	0.494713723214109	CD36/PPP1CA/MAPK8/PRKCE/MAPK10/PRKCQ/PIK3R1/CREB5	-2.21458785404884
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/1391	82/9376	0.41100454138977	PDIA3/CALR/KLRC1/KLRD1/IFNG	-2.23578110379717
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/1391	298/9376	0.633333172503968	BMP7/BMP4/BMP5/ACVRL1/CD40/CNTFR/XCL1/IL1B/EDA/TGFB3/CCL3L1/CCL4L2/IL7R/CXCR4/XCL2/IL32/CXCL14/CX3CR1/TNFSF15/ACVR1/CSF1/IL2RG/IL15/OSMR/IL3RA/TNFRSF11B/IL1RL1/IFNG	-2.684703980575
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1391	41/9376	0.164401816555908	GABRG2	-2.23791711334428
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1391	86/9376	0.235132830655543	PLCB1/PRKACB/PLCB4	-2.97398745023896
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	9/1391	183/9376	0.331498744858635	NOP10/XRN2/CSNK2A1/RPP38/POP7/RIOK1/IMP3/RPP30/NHP2	-3.81163130159871
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	26/1391	370/9376	0.47365496337459	NPFFR2/HRH2/SSTR1/LPAR1/TSPO/GRIK1/GZMA/NR3C1/P2RY8/GLRB/S1PR3/P2RX1/PTGER4/LYPD6/NPY1R/CHRM2/TACR1/SCT/PENK/GIP/S1PR2/PTGFR/GRIK2/S1PR5/PTGDR/GABRG2	-4.3113885660082
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/1391	323/9376	0.417366840792089	VIM/PLAU/ZFPM2/EFNA5/NOTCH3/CDK6/PDGFRA/SOS1/EZR/PRKCG/PDCD4/PRKCE/PRKCA/PTGS2/ZEB2/PIK3R1/FGFR3/CDKN2A/SLC45A3/ROCK1	-4.44745888395816
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1391	449/9376	0.135109733427907	PRKG1/NCALD/CALM1/CAMK2D/ADCY3/SLC8A1/PRKACB/GNB1/OR2C3	-7.83868397378915