ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 97/2769 175/18639 0.554285714285714 3.7310694938864 6.87680675002503e-36 8.80918944678207e-33 GO:0009055 electron transfer activity 52/2769 116/18639 0.448275862068966 3.01748421563866 9.56070864223746e-15 6.12363388535309e-12 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 34/2769 68/18639 0.5 3.36565547128927 8.95795565186818e-12 3.82504706334771e-09 GO:0003954 NADH dehydrogenase activity 25/2769 44/18639 0.568181818181818 3.82460849010145 1.40426378554788e-10 4.49715477321708e-08 GO:0004812 aminoacyl-tRNA ligase activity 23/2769 41/18639 0.560975609756098 3.77610126047089 1.08839970715711e-09 1.99177146409751e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity 23/2769 41/18639 0.560975609756098 3.77610126047089 1.08839970715711e-09 1.99177146409751e-07 GO:0016875 ligase activity, forming carbon-oxygen bonds 23/2769 41/18639 0.560975609756098 3.77610126047089 1.08839970715711e-09 1.99177146409751e-07 GO:0015078 proton transmembrane transporter activity 60/2769 185/18639 0.324324324324324 2.18312787326872 1.24442936585e-09 1.99264252206732e-07 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 27/2769 58/18639 0.46551724137931 3.13354130085553 9.05161532639494e-09 1.28834658145688e-06 GO:0022853 active monoatomic ion transmembrane transporter activity 42/2769 118/18639 0.355932203389831 2.39589033549406 1.82694221709218e-08 2.34031298009509e-06 GO:0016874 ligase activity 52/2769 167/18639 0.311377245508982 2.09597705996458 7.00371192021526e-08 8.1561408816325e-06 GO:0140101 catalytic activity, acting on a tRNA 44/2769 139/18639 0.316546762589928 2.1307746868594 4.1466892076548e-07 4.4265907291715e-05 GO:0016651 oxidoreductase activity, acting on NAD(P)H 32/2769 88/18639 0.363636363636364 2.44774943366493 5.04060105034971e-07 4.96693072730614e-05 GO:0015399 primary active transmembrane transporter activity 47/2769 166/18639 0.283132530120482 1.90585309819995 5.71016725140545e-06 0.000522480303503598 GO:0019843 rRNA binding 24/2769 65/18639 0.369230769230769 2.48540711725977 9.66492763124241e-06 0.000825384819708101 GO:0016859 cis-trans isomerase activity 18/2769 42/18639 0.428571428571429 2.88484754681938 1.1473175312458e-05 0.000918571098453672 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 16/2769 36/18639 0.444444444444444 2.99169375225713 2.01588684674472e-05 0.00135913213193683 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 16/2769 36/18639 0.444444444444444 2.99169375225713 2.01588684674472e-05 0.00135913213193683 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 16/2769 36/18639 0.444444444444444 2.99169375225713 2.01588684674472e-05 0.00135913213193683 GO:1990948 ubiquitin ligase inhibitor activity 8/2769 11/18639 0.727272727272727 4.89549886732985 2.54260923580138e-05 0.00162854121553079 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 16/2769 39/18639 0.41025641025641 2.76156346362197 6.67836406583119e-05 0.00396005323089693 GO:0008200 ion channel inhibitor activity 17/2769 43/18639 0.395348837209302 2.66121595404268 6.96742507395701e-05 0.00396005323089693 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 10/2769 18/18639 0.555555555555556 3.73961719032142 7.14648596381734e-05 0.00396005323089693 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/2769 15/18639 0.6 4.03878656554713 7.41930347709026e-05 0.00396005323089693 GO:0016248 channel inhibitor activity 17/2769 44/18639 0.386363636363636 2.60073377326898 9.79290589536401e-05 0.00501788498078452 GO:0141110 transporter inhibitor activity 17/2769 45/18639 0.377777777777778 2.54293968941856 0.000135758354016758 0.00668870967290256 GO:0003779 actin binding 94/2769 443/18639 0.212189616252822 1.42831428578416 0.000172646419311281 0.00819111344954632 GO:0016853 isomerase activity 45/2769 180/18639 0.25 1.68282773564464 0.000234652176592826 0.0107353370791218 GO:0099106 ion channel regulator activity 41/2769 160/18639 0.25625 1.72489842903575 0.000249112163985383 0.0110038855884578 GO:0016247 channel regulator activity 42/2769 168/18639 0.25 1.68282773564464 0.000371824005018723 0.0158768850142995 GO:0005246 calcium channel regulator activity 18/2769 53/18639 0.339622641509434 2.28610560313988 0.000409942850070413 0.0169398964819419 GO:0141108 transporter regulator activity 42/2769 170/18639 0.247058823529412 1.66302976228411 0.000484655562557425 0.019323605062525 GO:0061650 ubiquitin-like protein conjugating enzyme activity 15/2769 41/18639 0.365853658536585 2.46267473508971 0.00049779778849596 0.019323605062525 GO:0004129 cytochrome-c oxidase activity 8/2769 15/18639 0.533333333333333 3.59003250270856 0.000566582135957811 0.0201608810044988 GO:0031386 protein tag activity 8/2769 15/18639 0.533333333333333 3.59003250270856 0.000566582135957811 0.0201608810044988 GO:0141047 molecular tag activity 8/2769 15/18639 0.533333333333333 3.59003250270856 0.000566582135957811 0.0201608810044988 GO:0045296 cadherin binding 72/2769 334/18639 0.215568862275449 1.45106104151394 0.000591047702346192 0.0204630299109587 GO:0005201 extracellular matrix structural constituent 41/2769 168/18639 0.244047619047619 1.64276040860548 0.000731276100465406 0.024651702228847 GO:0003756 protein disulfide isomerase activity 9/2769 19/18639 0.473684210526316 3.18851570964247 0.000778391511387675 0.0249279881521903 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 9/2769 19/18639 0.473684210526316 3.18851570964247 0.000778391511387675 0.0249279881521903 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2769 16/18639 0.5 3.36565547128927 0.000985974764401106 0.030132823410541 GO:0015252 proton channel activity 11/2769 27/18639 0.407407407407407 2.74238593956904 0.000987961423296425 0.030132823410541 GO:0016209 antioxidant activity 24/2769 86/18639 0.27906976744186 1.87850537932425 0.00129468632388209 0.0385696088579757 GO:0019902 phosphatase binding 44/2769 190/18639 0.231578947368421 1.55882990249187 0.00151073365827331 0.0439829503692751 GO:1901681 sulfur compound binding 59/2769 275/18639 0.214545454545455 1.44417216586231 0.00196683141892828 0.0559891343921583 GO:0051015 actin filament binding 47/2769 209/18639 0.22488038277512 1.51373978134542 0.00202696764708679 0.0564466425199604 GO:0017124 SH3 domain binding 29/2769 115/18639 0.252173913043478 1.69746102030242 0.00243354253246882 0.0661419753507723 GO:0044325 transmembrane transporter binding 33/2769 136/18639 0.242647058823529 1.63333280224332 0.0025230795515269 0.0661419753507723 GO:0019210 kinase inhibitor activity 24/2769 90/18639 0.266666666666667 1.79501625135428 0.00253002091505687 0.0661419753507723 GO:0016922 nuclear receptor binding 33/2769 137/18639 0.240875912408759 1.62141066500067 0.00285938132591566 0.0732573495699592 GO:0061631 ubiquitin conjugating enzyme activity 12/2769 35/18639 0.342857142857143 2.3078780374555 0.00335707739927176 0.0843218852640613 GO:0004602 glutathione peroxidase activity 9/2769 23/18639 0.391304347826087 2.6339912384003 0.00393190605235222 0.0968609933281384 GO:0055106 ubiquitin-protein transferase regulator activity 12/2769 36/18639 0.333333333333333 2.24377031419285 0.004365505661185 0.105513448150528 GO:0004860 protein kinase inhibitor activity 22/2769 84/18639 0.261904761904762 1.76296238972295 0.00473226866405453 0.11225992886396 GO:0051020 GTPase binding 64/2769 315/18639 0.203174603174603 1.36763142960326 0.00502358902834358 0.117003955369239 GO:0008142 oxysterol binding 7/2769 16/18639 0.4375 2.94494853737812 0.00526783549164708 0.118387671312279 GO:0034450 ubiquitin-ubiquitin ligase activity 7/2769 16/18639 0.4375 2.94494853737812 0.00526783549164708 0.118387671312279 GO:0048027 mRNA 5'-UTR binding 9/2769 24/18639 0.375 2.52424160346696 0.00547289463981528 0.120875483337989 GO:0005518 collagen binding 19/2769 72/18639 0.263888888888889 1.77631816540267 0.00761785690535611 0.165397876199342 GO:0032977 membrane insertase activity 7/2769 17/18639 0.411764705882353 2.77171627047352 0.00782060438475743 0.165838718680478 GO:0015035 protein-disulfide reductase activity 11/2769 34/18639 0.323529411764706 2.17777706965777 0.00802152560429836 0.165838718680478 GO:0019207 kinase regulator activity 58/2769 287/18639 0.202090592334495 1.36033461557337 0.00815600475106011 0.165838718680478 GO:0044389 ubiquitin-like protein ligase binding 64/2769 322/18639 0.198757763975155 1.33790031156841 0.00827246380642317 0.165838718680478 GO:0051219 phosphoprotein binding 23/2769 93/18639 0.247311827956989 1.66473281375599 0.00828546291612068 0.165838718680478 GO:0140098 catalytic activity, acting on RNA 75/2769 387/18639 0.193798449612403 1.30451762453073 0.00853814402863417 0.168267115395083 GO:0005528 FK506 binding 5/2769 10/18639 0.5 3.36565547128927 0.0094528357817088 0.180732576662224 GO:0050815 phosphoserine residue binding 5/2769 10/18639 0.5 3.36565547128927 0.0094528357817088 0.180732576662224 GO:0019887 protein kinase regulator activity 52/2769 255/18639 0.203921568627451 1.37265948632974 0.00987169001881162 0.185118009488763 GO:0051117 ATPase binding 21/2769 84/18639 0.25 1.68282773564464 0.00997122767738067 0.185118009488763 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 15/2769 54/18639 0.277777777777778 1.86980859516071 0.0102896039996322 0.185847785763086 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 16/2769 59/18639 0.271186440677966 1.82544025561452 0.0104457771857472 0.185847785763086 GO:0045309 protein phosphorylated amino acid binding 16/2769 59/18639 0.271186440677966 1.82544025561452 0.0104457771857472 0.185847785763086 GO:0016530 metallochaperone activity 6/2769 14/18639 0.428571428571429 2.88484754681938 0.0109707648991773 0.190489796153103 GO:0015036 disulfide oxidoreductase activity 12/2769 40/18639 0.3 2.01939328277356 0.0110317046736107 0.190489796153103 GO:0043021 ribonucleoprotein complex binding 38/2769 177/18639 0.214689265536723 1.4451402023615 0.0111527983696196 0.190489796153103 GO:0000049 tRNA binding 20/2769 80/18639 0.25 1.68282773564464 0.011724298281883 0.196620991357098 GO:0005178 integrin binding 35/2769 161/18639 0.217391304347826 1.46332846577795 0.0119350107646401 0.196620991357098 GO:0019003 GDP binding 19/2769 75/18639 0.253333333333333 1.70526543878657 0.0119722383496125 0.196620991357098 GO:0030695 GTPase regulator activity 91/2769 489/18639 0.186094069529652 1.25265704657392 0.0123578538770191 0.200384947043817 GO:0005484 SNAP receptor activity 11/2769 36/18639 0.305555555555556 2.05678945467678 0.0127087101945858 0.200916660638508 GO:0044390 ubiquitin-like protein conjugating enzyme binding 11/2769 36/18639 0.305555555555556 2.05678945467678 0.0127087101945858 0.200916660638508 GO:0001671 ATPase activator activity 9/2769 27/18639 0.333333333333333 2.24377031419285 0.0129413606120272 0.200916660638508 GO:0060589 nucleoside-triphosphatase regulator activity 91/2769 490/18639 0.185714285714286 1.25010060362173 0.0130180193856332 0.200916660638508 GO:0004713 protein tyrosine kinase activity 31/2769 140/18639 0.221428571428571 1.49050456585668 0.0133285134593323 0.203259830254817 GO:0005543 phospholipid binding 92/2769 497/18639 0.185110663983903 1.24603743806283 0.0136770656397138 0.206121424523216 GO:0003924 GTPase activity 64/2769 331/18639 0.193353474320242 1.30152235747742 0.0149036889295603 0.218336827277599 GO:0050786 RAGE receptor binding 5/2769 11/18639 0.454545454545455 3.05968679208116 0.015233116092536 0.218336827277599 GO:0070990 snRNP binding 5/2769 11/18639 0.454545454545455 3.05968679208116 0.015233116092536 0.218336827277599 GO:0031625 ubiquitin protein ligase binding 59/2769 302/18639 0.195364238410596 1.31505743580177 0.0153562518257165 0.218336827277599 GO:0051540 metal cluster binding 19/2769 77/18639 0.246753246753247 1.66097282998691 0.0158348397782098 0.218336827277599 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/2769 15/18639 0.4 2.69252437703142 0.0160215938829776 0.218336827277599 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/2769 15/18639 0.4 2.69252437703142 0.0160215938829776 0.218336827277599 GO:0008252 nucleotidase activity 6/2769 15/18639 0.4 2.69252437703142 0.0160215938829776 0.218336827277599 GO:0045504 dynein heavy chain binding 6/2769 15/18639 0.4 2.69252437703142 0.0160215938829776 0.218336827277599 GO:0004857 enzyme inhibitor activity 78/2769 416/18639 0.1875 1.26212080173348 0.0163269058191589 0.219550572514707 GO:0031492 nucleosomal DNA binding 12/2769 42/18639 0.285714285714286 1.92323169787959 0.0164534386896268 0.219550572514707 GO:0004601 peroxidase activity 15/2769 57/18639 0.263157894736842 1.77139761646804 0.0170400220909408 0.221123146297036 GO:0035401 histone H3Y41 kinase activity 26/2769 115/18639 0.226086956521739 1.52186160440906 0.0170891424538693 0.221123146297036 GO:0140801 histone H2AXY142 kinase activity 26/2769 115/18639 0.226086956521739 1.52186160440906 0.0170891424538693 0.221123146297036 GO:0035035 histone acetyltransferase binding 8/2769 24/18639 0.333333333333333 2.24377031419285 0.0187465495044803 0.240143299152393 GO:0033218 amide binding 49/2769 247/18639 0.198380566801619 1.33536128010668 0.0195078837953789 0.243817414115333 GO:0005507 copper ion binding 16/2769 63/18639 0.253968253968254 1.70953928700408 0.0195932016762474 0.243817414115333 GO:0019903 protein phosphatase binding 31/2769 144/18639 0.215277777777778 1.44910166124955 0.019604366630663 0.243817414115333 GO:0016860 intramolecular oxidoreductase activity 14/2769 53/18639 0.264150943396226 1.77808213577547 0.0200940772715796 0.247504932547053 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 28/2769 128/18639 0.21875 1.47247426868906 0.020974622390167 0.254737913015135 GO:0019208 phosphatase regulator activity 26/2769 117/18639 0.222222222222222 1.49584687612857 0.0210790154407528 0.254737913015135 GO:0015631 tubulin binding 72/2769 385/18639 0.187012987012987 1.25884256588482 0.0214918943375971 0.257300155574411 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/2769 16/18639 0.375 2.52424160346696 0.0224738489177759 0.261980221697562 GO:0043023 ribosomal large subunit binding 6/2769 16/18639 0.375 2.52424160346696 0.0224738489177759 0.261980221697562 GO:0004300 enoyl-CoA hydratase activity 5/2769 12/18639 0.416666666666667 2.80471289274106 0.0229686450609138 0.261980221697562 GO:0005527 macrolide binding 5/2769 12/18639 0.416666666666667 2.80471289274106 0.0229686450609138 0.261980221697562 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 11/2769 39/18639 0.282051282051282 1.8985748812401 0.0232806957995884 0.261980221697562 GO:0019888 protein phosphatase regulator activity 24/2769 107/18639 0.224299065420561 1.50982675347556 0.0233433656545656 0.261980221697562 GO:0003925 G protein activity 14/2769 54/18639 0.259259259259259 1.74515468881666 0.0235256429167613 0.261980221697562 GO:0030020 extracellular matrix structural constituent conferring tensile strength 12/2769 44/18639 0.272727272727273 1.83581207524869 0.0236707873312573 0.261980221697562 GO:0060590 ATPase regulator activity 13/2769 49/18639 0.26530612244898 1.7858580051739 0.023723423666602 0.261980221697562 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/2769 21/18639 0.333333333333333 2.24377031419285 0.0273167719863203 0.296514740845566 GO:0009931 calcium-dependent protein serine/threonine kinase activity 7/2769 21/18639 0.333333333333333 2.24377031419285 0.0273167719863203 0.296514740845566 GO:0051536 iron-sulfur cluster binding 18/2769 76/18639 0.236842105263158 1.59425785482124 0.0275450852151618 0.296514740845566 GO:0004715 non-membrane spanning protein tyrosine kinase activity 12/2769 45/18639 0.266666666666667 1.79501625135428 0.0280451562519227 0.296907811229033 GO:0051539 4 iron, 4 sulfur cluster binding 12/2769 45/18639 0.266666666666667 1.79501625135428 0.0280451562519227 0.296907811229033 GO:0003712 transcription coregulator activity 89/2769 495/18639 0.17979797979798 1.21027610886766 0.02989749696496 0.307355850549723 GO:0043177 organic acid binding 38/2769 189/18639 0.201058201058201 1.35338526887823 0.0299399864748322 0.307355850549723 GO:0000287 magnesium ion binding 45/2769 230/18639 0.195652173913043 1.31699561920015 0.0302317443277761 0.307355850549723 GO:0005085 guanyl-nucleotide exchange factor activity 45/2769 230/18639 0.195652173913043 1.31699561920015 0.0302317443277761 0.307355850549723 GO:0043548 phosphatidylinositol 3-kinase binding 8/2769 26/18639 0.307692307692308 2.07117259771648 0.0303593371395182 0.307355850549723 GO:0005539 glycosaminoglycan binding 47/2769 242/18639 0.194214876033058 1.30732072025286 0.0306837525718965 0.307355850549723 GO:0008201 heparin binding 35/2769 172/18639 0.203488372093023 1.36974350575726 0.030711591624016 0.307355850549723 GO:0016597 amino acid binding 13/2769 51/18639 0.254901960784314 1.71582435791218 0.0324331257330431 0.316398943222065 GO:0008253 5'-nucleotidase activity 5/2769 13/18639 0.384615384615385 2.5889657471456 0.0328501635039303 0.316398943222065 GO:0019855 calcium channel inhibitor activity 5/2769 13/18639 0.384615384615385 2.5889657471456 0.0328501635039303 0.316398943222065 GO:0039706 co-receptor binding 5/2769 13/18639 0.384615384615385 2.5889657471456 0.0328501635039303 0.316398943222065 GO:0070700 BMP receptor binding 5/2769 13/18639 0.384615384615385 2.5889657471456 0.0328501635039303 0.316398943222065 GO:0017080 sodium channel regulator activity 11/2769 41/18639 0.268292682926829 1.80596147239912 0.0332031315918903 0.317412026635906 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 26/2769 122/18639 0.213114754098361 1.43454167628723 0.0342388285412073 0.324888439713234 GO:0003713 transcription coactivator activity 49/2769 256/18639 0.19140625 1.28841498510293 0.0351684933390024 0.331256176229868 GO:0098641 cadherin binding involved in cell-cell adhesion 6/2769 18/18639 0.333333333333333 2.24377031419285 0.0401094688642757 0.375038172373264 GO:0031491 nucleosome binding 17/2769 74/18639 0.22972972972973 1.54638224356534 0.0412744848985558 0.383134892427898 GO:0005096 GTPase activator activity 51/2769 271/18639 0.188191881918819 1.2667780740646 0.0421932307018887 0.388845528986471 GO:0004864 protein phosphatase inhibitor activity 13/2769 53/18639 0.245283018867925 1.65107626893436 0.0432359782444917 0.391567389631789 GO:0019787 ubiquitin-like protein transferase activity 85/2769 479/18639 0.177453027139875 1.19449150338033 0.0436457870457395 0.391567389631789 GO:0035091 phosphatidylinositol binding 53/2769 284/18639 0.186619718309859 1.25619535196008 0.044605066402545 0.391567389631789 GO:0005496 steroid binding 23/2769 108/18639 0.212962962962963 1.43351992295654 0.0447023800889369 0.391567389631789 GO:0008191 metalloendopeptidase inhibitor activity 5/2769 14/18639 0.357142857142857 2.40403962234948 0.0450053849510153 0.391567389631789 GO:0032036 myosin heavy chain binding 5/2769 14/18639 0.357142857142857 2.40403962234948 0.0450053849510153 0.391567389631789 GO:0034236 protein kinase A catalytic subunit binding 5/2769 14/18639 0.357142857142857 2.40403962234948 0.0450053849510153 0.391567389631789 GO:0044548 S100 protein binding 5/2769 14/18639 0.357142857142857 2.40403962234948 0.0450053849510153 0.391567389631789 GO:0140996 histone H3 kinase activity 65/2769 357/18639 0.182072829131653 1.22558882708013 0.0452396359605814 0.391567389631789 GO:0046966 nuclear thyroid hormone receptor binding 8/2769 28/18639 0.285714285714286 1.92323169787959 0.0461252390736401 0.39655322988814 GO:0071889 14-3-3 protein binding 9/2769 33/18639 0.272727272727273 1.83581207524869 0.0467819874933803 0.399518173193468 GO:0005522 profilin binding 4/2769 10/18639 0.4 2.69252437703142 0.0483970824039151 0.410573924234538 GO:0022804 active transmembrane transporter activity 81/2769 457/18639 0.177242888402626 1.19307699419882 0.0490004378444067 0.41295763735977 GO:0051287 NAD binding 13/2769 54/18639 0.240740740740741 1.62050078247261 0.0494855967630404 0.414320584663103 GO:0005520 insulin-like growth factor binding 6/2769 19/18639 0.315789473684211 2.12567713976165 0.0514800871583058 0.425458010643805 GO:0140036 ubiquitin-modified protein reader activity 6/2769 19/18639 0.315789473684211 2.12567713976165 0.0514800871583058 0.425458010643805 GO:0035173 histone kinase activity 65/2769 360/18639 0.180555555555556 1.21537558685446 0.0522996382211234 0.429191591854568 GO:0141003 histone H2AX kinase activity 64/2769 354/18639 0.180790960451977 1.21696017040968 0.0526019359259697 0.429191591854568 GO:0051213 dioxygenase activity 20/2769 93/18639 0.21505376344086 1.44759375109216 0.0533551186990876 0.430411093889769 GO:0001098 basal transcription machinery binding 14/2769 60/18639 0.233333333333333 1.57063921993499 0.0537593872149594 0.430411093889769 GO:0001099 basal RNA polymerase II transcription machinery binding 14/2769 60/18639 0.233333333333333 1.57063921993499 0.0537593872149594 0.430411093889769 GO:0050431 transforming growth factor beta binding 7/2769 24/18639 0.291666666666667 1.96329902491874 0.0546013050906966 0.434436470939021 GO:0003785 actin monomer binding 8/2769 29/18639 0.275862068965517 1.85691336346994 0.0557000404079763 0.435071657089132 GO:0051861 glycolipid binding 8/2769 29/18639 0.275862068965517 1.85691336346994 0.0557000404079763 0.435071657089132 GO:0099604 ligand-gated calcium channel activity 8/2769 29/18639 0.275862068965517 1.85691336346994 0.0557000404079763 0.435071657089132 GO:0005006 epidermal growth factor receptor activity 12/2769 50/18639 0.24 1.61551462621885 0.0588641771733181 0.453666763698384 GO:0031406 carboxylic acid binding 36/2769 187/18639 0.192513368983957 1.29586734723437 0.0589355953245121 0.453666763698384 GO:0017081 chloride channel regulator activity 5/2769 15/18639 0.333333333333333 2.24377031419285 0.059497280485034 0.453666763698384 GO:0033130 acetylcholine receptor binding 5/2769 15/18639 0.333333333333333 2.24377031419285 0.059497280485034 0.453666763698384 GO:0140297 DNA-binding transcription factor binding 85/2769 488/18639 0.174180327868852 1.17246194696553 0.0630123408281054 0.466712740639517 GO:0016829 lyase activity 38/2769 200/18639 0.19 1.27894907908992 0.06317542226613 0.466712740639517 GO:0005200 structural constituent of cytoskeleton 23/2769 112/18639 0.205357142857143 1.38232278285095 0.0635795262698421 0.466712740639517 GO:0019212 phosphatase inhibitor activity 13/2769 56/18639 0.232142857142857 1.56262575452716 0.0637846473049275 0.466712740639517 GO:0016505 peptidase activator activity involved in apoptotic process 6/2769 20/18639 0.3 2.01939328277356 0.0646217704154803 0.466712740639517 GO:0031624 ubiquitin conjugating enzyme binding 8/2769 30/18639 0.266666666666667 1.79501625135428 0.0664488552291598 0.466712740639517 GO:0070566 adenylyltransferase activity 8/2769 30/18639 0.266666666666667 1.79501625135428 0.0664488552291598 0.466712740639517 GO:0005021 vascular endothelial growth factor receptor activity 12/2769 51/18639 0.235294117647059 1.58383786884201 0.0669968083857103 0.466712740639517 GO:0003953 NAD+ nucleosidase activity 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0034056 estrogen response element binding 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0034713 type I transforming growth factor beta receptor binding 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0035252 UDP-xylosyltransferase activity 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0042285 xylosyltransferase activity 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0042608 T cell receptor binding 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0048185 activin binding 4/2769 11/18639 0.363636363636364 2.44774943366493 0.0673479202961317 0.466712740639517 GO:0016755 aminoacyltransferase activity 86/2769 496/18639 0.173387096774194 1.16712246181805 0.0674269050107086 0.466712740639517 GO:0019838 growth factor binding 27/2769 136/18639 0.198529411764706 1.33636320183545 0.0677662527392273 0.466712740639517 GO:0030276 clathrin binding 11/2769 46/18639 0.239130434782609 1.60966131235574 0.070188924646093 0.479772165673267 GO:0016835 carbon-oxygen lyase activity 17/2769 79/18639 0.215189873417722 1.4485099496688 0.0704115278271461 0.479772165673267 GO:0032934 sterol binding 15/2769 68/18639 0.220588235294118 1.48484800203939 0.0716903916085119 0.484528643083002 GO:0016504 peptidase activator activity 13/2769 57/18639 0.228070175438596 1.53521126760563 0.0718660750864718 0.484528643083002 GO:0000993 RNA polymerase II complex binding 9/2769 36/18639 0.25 1.68282773564464 0.076081274691823 0.509238285275996 GO:0000062 fatty-acyl-CoA binding 5/2769 16/18639 0.3125 2.1035346695558 0.0763261130156059 0.509238285275996 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 26/2769 132/18639 0.196969696969697 1.3258642765685 0.0776878564631218 0.513572043195549 GO:0019955 cytokine binding 28/2769 144/18639 0.194444444444444 1.3088660166125 0.0789194374417106 0.513572043195549 GO:0072542 protein phosphatase activator activity 6/2769 21/18639 0.285714285714286 1.92323169787959 0.0795437697871443 0.513572043195549 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/2769 26/18639 0.269230769230769 1.81227602300192 0.0797820738453664 0.513572043195549 GO:0034237 protein kinase A regulatory subunit binding 7/2769 26/18639 0.269230769230769 1.81227602300192 0.0797820738453664 0.513572043195549 GO:0050681 nuclear androgen receptor binding 7/2769 26/18639 0.269230769230769 1.81227602300192 0.0797820738453664 0.513572043195549 GO:0097602 cullin family protein binding 7/2769 26/18639 0.269230769230769 1.81227602300192 0.0797820738453664 0.513572043195549 GO:0043175 RNA polymerase core enzyme binding 10/2769 42/18639 0.238095238095238 1.60269308156632 0.0839295738046853 0.534894447979114 GO:0048487 beta-tubulin binding 10/2769 42/18639 0.238095238095238 1.60269308156632 0.0839295738046853 0.534894447979114 GO:0051018 protein kinase A binding 12/2769 53/18639 0.226415094339623 1.52407040209326 0.0853670663060605 0.541362435336948 GO:0008081 phosphoric diester hydrolase activity 18/2769 87/18639 0.206896551724138 1.39268502260246 0.0873854367552396 0.551432238834788 GO:0016423 tRNA (guanine) methyltransferase activity 4/2769 12/18639 0.333333333333333 2.24377031419285 0.0895375579137408 0.553948963555373 GO:0031543 peptidyl-proline dioxygenase activity 4/2769 12/18639 0.333333333333333 2.24377031419285 0.0895375579137408 0.553948963555373 GO:0097371 MDM2/MDM4 family protein binding 4/2769 12/18639 0.333333333333333 2.24377031419285 0.0895375579137408 0.553948963555373 GO:0051087 protein-folding chaperone binding 26/2769 134/18639 0.194029850746269 1.30607525751524 0.0895733286412945 0.553948963555373 GO:0070063 RNA polymerase binding 13/2769 59/18639 0.220338983050847 1.4831702076868 0.0899464359246819 0.553948963555373 GO:0004364 glutathione transferase activity 7/2769 27/18639 0.259259259259259 1.74515468881666 0.094513171993625 0.555068320486762 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0015278 intracellularly gated calcium channel activity 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0019198 transmembrane receptor protein phosphatase activity 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0051787 misfolded protein binding 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0070402 NADPH binding 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0070492 oligosaccharide binding 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:1901567 fatty acid derivative binding 5/2769 17/18639 0.294117647058824 1.97979733605251 0.0954342735412884 0.555068320486762 GO:0050661 NADP binding 12/2769 54/18639 0.222222222222222 1.49584687612857 0.0956189147469236 0.555068320486762 GO:0004842 ubiquitin-protein transferase activity 77/2769 449/18639 0.171492204899777 1.15436735540879 0.0957666056136899 0.555068320486762 GO:0140035 ubiquitin-like protein reader activity 6/2769 22/18639 0.272727272727273 1.83581207524869 0.0962223681220633 0.555068320486762 GO:0043130 ubiquitin binding 20/2769 100/18639 0.2 1.34626218851571 0.0984090314636668 0.555068320486762 GO:0000149 SNARE binding 21/2769 106/18639 0.19811320754717 1.3335616018316 0.099570774187457 0.555068320486762 GO:0004714 transmembrane receptor protein tyrosine kinase activity 13/2769 60/18639 0.216666666666667 1.45845070422535 0.0999556196103498 0.555068320486762 GO:0043022 ribosome binding 22/2769 112/18639 0.196428571428571 1.32222179229221 0.100515194429399 0.555068320486762 GO:0005004 GPI-linked ephrin receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0005008 hepatocyte growth factor receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0005009 insulin receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0005011 macrophage colony-stimulating factor receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0005018 platelet-derived growth factor alpha-receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0005020 stem cell factor receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0008288 boss receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0036332 placental growth factor receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0038062 protein tyrosine kinase collagen receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0060175 brain-derived neurotrophic factor receptor activity 11/2769 49/18639 0.224489795918367 1.51111061976253 0.101619229984625 0.555068320486762 GO:0001540 amyloid-beta binding 17/2769 83/18639 0.204819277108434 1.37870224125103 0.101827521713028 0.555068320486762 GO:0042578 phosphoric ester hydrolase activity 63/2769 363/18639 0.173553719008264 1.16824404788553 0.102349850022306 0.555551516434634 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/2769 33/18639 0.242424242424242 1.63183295577662 0.105840221391627 0.569669426901994 GO:0019956 chemokine binding 8/2769 33/18639 0.242424242424242 1.63183295577662 0.105840221391627 0.569669426901994 GO:0031267 small GTPase binding 50/2769 283/18639 0.176678445229682 1.18927755169232 0.106298236524245 0.569740757270116 GO:0019205 nucleobase-containing compound kinase activity 10/2769 44/18639 0.227272727272727 1.52984339604058 0.107934884244808 0.573711978081325 GO:0030547 signaling receptor inhibitor activity 10/2769 44/18639 0.227272727272727 1.52984339604058 0.107934884244808 0.573711978081325 GO:0016836 hydro-lyase activity 13/2769 61/18639 0.213114754098361 1.43454167628723 0.110611152299026 0.577256409634494 GO:0051537 2 iron, 2 sulfur cluster binding 7/2769 28/18639 0.25 1.68282773564464 0.110642482966954 0.577256409634494 GO:0003714 transcription corepressor activity 37/2769 204/18639 0.181372549019608 1.22087502389905 0.111900117316942 0.577256409634494 GO:0005007 fibroblast growth factor receptor activity 11/2769 50/18639 0.22 1.48088840736728 0.113678347444225 0.577256409634494 GO:0005017 platelet-derived growth factor receptor activity 11/2769 50/18639 0.22 1.48088840736728 0.113678347444225 0.577256409634494 GO:0005019 platelet-derived growth factor beta-receptor activity 11/2769 50/18639 0.22 1.48088840736728 0.113678347444225 0.577256409634494 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 14/2769 67/18639 0.208955223880597 1.40654258501641 0.113879118730936 0.577256409634494 GO:0050840 extracellular matrix binding 14/2769 67/18639 0.208955223880597 1.40654258501641 0.113879118730936 0.577256409634494 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/2769 23/18639 0.260869565217391 1.75599415893353 0.114603085796421 0.577256409634494 GO:0002161 aminoacyl-tRNA editing activity 4/2769 13/18639 0.307692307692308 2.07117259771648 0.114731955429212 0.577256409634494 GO:0031432 titin binding 4/2769 13/18639 0.307692307692308 2.07117259771648 0.114731955429212 0.577256409634494 GO:0031994 insulin-like growth factor I binding 4/2769 13/18639 0.307692307692308 2.07117259771648 0.114731955429212 0.577256409634494 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/2769 13/18639 0.307692307692308 2.07117259771648 0.114731955429212 0.577256409634494 GO:0032182 ubiquitin-like protein binding 23/2769 120/18639 0.191666666666667 1.29016793066089 0.116469030737627 0.577256409634494 GO:0008308 voltage-gated monoatomic anion channel activity 5/2769 18/18639 0.277777777777778 1.86980859516071 0.116713044570909 0.577256409634494 GO:0031690 adrenergic receptor binding 5/2769 18/18639 0.277777777777778 1.86980859516071 0.116713044570909 0.577256409634494 GO:0070064 proline-rich region binding 5/2769 18/18639 0.277777777777778 1.86980859516071 0.116713044570909 0.577256409634494 GO:1990381 ubiquitin-specific protease binding 5/2769 18/18639 0.277777777777778 1.86980859516071 0.116713044570909 0.577256409634494 GO:0046332 SMAD binding 16/2769 79/18639 0.20253164556962 1.36330348204122 0.118653634265319 0.58459732882259 GO:0106310 protein serine kinase activity 62/2769 361/18639 0.171745152354571 1.15607002337914 0.120894328581654 0.593354923038691 GO:0072341 modified amino acid binding 18/2769 91/18639 0.197802197802198 1.33146809853202 0.121689252504677 0.594976841444623 GO:0003697 single-stranded DNA binding 23/2769 121/18639 0.190082644628099 1.27950538577939 0.124569133059585 0.606741670909996 GO:0003743 translation initiation factor activity 11/2769 51/18639 0.215686274509804 1.45185137977184 0.126515770685316 0.609273316721392 GO:0005010 insulin-like growth factor receptor activity 11/2769 51/18639 0.215686274509804 1.45185137977184 0.126515770685316 0.609273316721392 GO:0005030 neurotrophin receptor activity 11/2769 51/18639 0.215686274509804 1.45185137977184 0.126515770685316 0.609273316721392 GO:0048306 calcium-dependent protein binding 16/2769 80/18639 0.2 1.34626218851571 0.12892522608197 0.618246296085714 GO:0030331 nuclear estrogen receptor binding 9/2769 40/18639 0.225 1.51454496208017 0.129344268033545 0.618246296085714 GO:0008170 N-methyltransferase activity 19/2769 98/18639 0.193877551020408 1.305050080704 0.13211786512407 0.62915607889938 GO:0061134 peptidase regulator activity 40/2769 226/18639 0.176991150442478 1.19138246771302 0.13329384249967 0.631601880097288 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/2769 24/18639 0.25 1.68282773564464 0.134603679364996 0.631601880097288 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/2769 24/18639 0.25 1.68282773564464 0.134603679364996 0.631601880097288 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/2769 24/18639 0.25 1.68282773564464 0.134603679364996 0.631601880097288 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2769 46/18639 0.217391304347826 1.46332846577795 0.135448863767354 0.633248155058323 GO:0005154 epidermal growth factor receptor binding 8/2769 35/18639 0.228571428571429 1.53858535830367 0.137910781516004 0.642413494989094 GO:0043395 heparan sulfate proteoglycan binding 5/2769 19/18639 0.263157894736842 1.77139761646804 0.140010529361124 0.647485516648375 GO:0120227 acyl-CoA binding 5/2769 19/18639 0.263157894736842 1.77139761646804 0.140010529361124 0.647485516648375 GO:0005525 GTP binding 64/2769 378/18639 0.169312169312169 1.13969285800272 0.142045299637159 0.654532477824463 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/2769 41/18639 0.219512195121951 1.47760484105383 0.145116012579778 0.666285348081347 GO:0001968 fibronectin binding 7/2769 30/18639 0.233333333333333 1.57063921993499 0.146894916976846 0.669652628638218 GO:0008106 alcohol dehydrogenase (NADP+) activity 7/2769 30/18639 0.233333333333333 1.57063921993499 0.146894916976846 0.669652628638218 GO:0140789 histone phosphatase activity 25/2769 136/18639 0.183823529411765 1.23737333503282 0.149474373877585 0.6789952941035 GO:0001784 phosphotyrosine residue binding 10/2769 47/18639 0.212765957446809 1.4321938175699 0.150469423321822 0.681100110513266 GO:0005003 ephrin receptor activity 11/2769 53/18639 0.207547169811321 1.39706453525215 0.154453670773747 0.683319975721302 GO:0005005 transmembrane-ephrin receptor activity 11/2769 53/18639 0.207547169811321 1.39706453525215 0.154453670773747 0.683319975721302 GO:0038064 collagen receptor activity 11/2769 53/18639 0.207547169811321 1.39706453525215 0.154453670773747 0.683319975721302 GO:0004869 cysteine-type endopeptidase inhibitor activity 8/2769 36/18639 0.222222222222222 1.49584687612857 0.155576354894341 0.683319975721302 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 59/2769 349/18639 0.169054441260745 1.13795801034996 0.156033949088057 0.683319975721302 GO:0003707 nuclear steroid receptor activity 6/2769 25/18639 0.24 1.61551462621885 0.156117698398817 0.683319975721302 GO:0017025 TBP-class protein binding 6/2769 25/18639 0.24 1.61551462621885 0.156117698398817 0.683319975721302 GO:0019211 phosphatase activator activity 6/2769 25/18639 0.24 1.61551462621885 0.156117698398817 0.683319975721302 GO:0019001 guanyl nucleotide binding 67/2769 400/18639 0.1675 1.12749458288191 0.157237045333909 0.683319975721302 GO:0032561 guanyl ribonucleotide binding 67/2769 400/18639 0.1675 1.12749458288191 0.157237045333909 0.683319975721302 GO:0001786 phosphatidylserine binding 12/2769 59/18639 0.203389830508475 1.36908019171089 0.157400419558962 0.683319975721302 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 17/2769 89/18639 0.191011235955056 1.28575602273972 0.162949821280143 0.683319975721302 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 17/2769 89/18639 0.191011235955056 1.28575602273972 0.162949821280143 0.683319975721302 GO:0016004 phospholipase activator activity 5/2769 20/18639 0.25 1.68282773564464 0.165140115676338 0.683319975721302 GO:0031418 L-ascorbic acid binding 5/2769 20/18639 0.25 1.68282773564464 0.165140115676338 0.683319975721302 GO:0017147 Wnt-protein binding 7/2769 31/18639 0.225806451612903 1.51997343864677 0.166875842836217 0.683319975721302 GO:0047499 calcium-independent phospholipase A2 activity 7/2769 31/18639 0.225806451612903 1.51997343864677 0.166875842836217 0.683319975721302 GO:0015485 cholesterol binding 11/2769 54/18639 0.203703703703704 1.37119296978452 0.169504422315493 0.683319975721302 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 12/2769 60/18639 0.2 1.34626218851571 0.171761619546116 0.683319975721302 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 12/2769 60/18639 0.2 1.34626218851571 0.171761619546116 0.683319975721302 GO:0000774 adenyl-nucleotide exchange factor activity 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0004865 protein serine/threonine phosphatase inhibitor activity 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0005523 tropomyosin binding 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0010181 FMN binding 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0016846 carbon-sulfur lyase activity 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0042809 nuclear vitamin D receptor binding 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0050700 CARD domain binding 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0120283 protein serine/threonine kinase binding 4/2769 15/18639 0.266666666666667 1.79501625135428 0.172849966578839 0.683319975721302 GO:0008017 microtubule binding 47/2769 276/18639 0.170289855072464 1.14627396485939 0.17356708299144 0.683319975721302 GO:0030551 cyclic nucleotide binding 8/2769 37/18639 0.216216216216216 1.45541858217915 0.174251296986637 0.683319975721302 GO:0005516 calmodulin binding 36/2769 207/18639 0.173913043478261 1.17066277262236 0.174490561489364 0.683319975721302 GO:0140793 histone H2AXY142 phosphatase activity 17/2769 90/18639 0.188888888888889 1.27146984470928 0.174709450901043 0.683319975721302 GO:0019199 transmembrane receptor protein kinase activity 15/2769 78/18639 0.192307692307692 1.2944828735728 0.174733203791307 0.683319975721302 GO:0000182 rDNA binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0004090 carbonyl reductase (NADPH) activity 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0004955 prostaglandin receptor activity 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0008140 cAMP response element binding protein binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0015279 store-operated calcium channel activity 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0016868 intramolecular phosphotransferase activity 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0033204 ribonuclease P RNA binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0035256 G protein-coupled glutamate receptor binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0035374 chondroitin sulfate binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0043208 glycosphingolipid binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0070513 death domain binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0097177 mitochondrial ribosome binding 3/2769 10/18639 0.3 2.01939328277356 0.176030907094481 0.683319975721302 GO:0030507 spectrin binding 6/2769 26/18639 0.230769230769231 1.55337944828736 0.179018385764852 0.690730578809566 GO:0120014 phospholipid transfer activity 6/2769 26/18639 0.230769230769231 1.55337944828736 0.179018385764852 0.690730578809566 GO:0001222 transcription corepressor binding 10/2769 49/18639 0.204081632653061 1.37373692705685 0.182872942769676 0.70137796313759 GO:0016763 pentosyltransferase activity 10/2769 49/18639 0.204081632653061 1.37373692705685 0.182872942769676 0.70137796313759 GO:0140313 molecular sequestering activity 11/2769 55/18639 0.2 1.34626218851571 0.185234660791249 0.708315225294299 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 12/2769 61/18639 0.19672131147541 1.32419231657283 0.186737244178055 0.710311167782604 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2769 32/18639 0.21875 1.47247426868906 0.187974618171977 0.710311167782604 GO:0043425 bHLH transcription factor binding 7/2769 32/18639 0.21875 1.47247426868906 0.187974618171977 0.710311167782604 GO:0047498 calcium-dependent phospholipase A2 activity 7/2769 32/18639 0.21875 1.47247426868906 0.187974618171977 0.710311167782604 GO:0005123 death receptor binding 5/2769 21/18639 0.238095238095238 1.60269308156632 0.191888973766712 0.722969927632817 GO:0042162 telomeric DNA binding 8/2769 38/18639 0.210526315789474 1.41711809317443 0.193865139645688 0.728273442481309 GO:0001046 core promoter sequence-specific DNA binding 9/2769 44/18639 0.204545454545455 1.37685905643652 0.197723376562085 0.737944831216832 GO:0043014 alpha-tubulin binding 9/2769 44/18639 0.204545454545455 1.37685905643652 0.197723376562085 0.737944831216832 GO:0004725 protein tyrosine phosphatase activity 18/2769 98/18639 0.183673469387755 1.23636323435116 0.198205986801357 0.737944831216832 GO:0043178 alcohol binding 17/2769 92/18639 0.184782608695652 1.24382919591125 0.199475795424738 0.737944831216832 GO:0052689 carboxylic ester hydrolase activity 17/2769 92/18639 0.184782608695652 1.24382919591125 0.199475795424738 0.737944831216832 GO:1901981 phosphatidylinositol phosphate binding 32/2769 185/18639 0.172972972972973 1.16433486574332 0.199896062788634 0.737944831216832 GO:0035591 signaling adaptor activity 23/2769 129/18639 0.178294573643411 1.20015621456827 0.200987318690165 0.739841250695693 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/2769 16/18639 0.25 1.68282773564464 0.20502458443325 0.750389979025694 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2769 16/18639 0.25 1.68282773564464 0.20502458443325 0.750389979025694 GO:0002020 protease binding 24/2769 136/18639 0.176470588235294 1.18787840163151 0.209535805063173 0.761766421442234 GO:0140416 transcription regulator inhibitor activity 7/2769 33/18639 0.212121212121212 1.42785383630454 0.210087724997456 0.761766421442234 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/2769 39/18639 0.205128205128205 1.38078173181098 0.214339176201711 0.761766421442234 GO:0004954 prostanoid receptor activity 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0008526 phosphatidylinositol transfer activity 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0010854 adenylate cyclase regulator activity 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0019215 intermediate filament binding 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0034511 U3 snoRNA binding 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0097493 structural molecule activity conferring elasticity 3/2769 11/18639 0.272727272727273 1.83581207524869 0.216787027143861 0.761766421442234 GO:0016830 carbon-carbon lyase activity 10/2769 51/18639 0.196078431372549 1.31986489070168 0.218136425970727 0.761766421442234 GO:0061659 ubiquitin-like protein ligase activity 61/2769 372/18639 0.163978494623656 1.10379023520777 0.218343312128882 0.761766421442234 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/2769 22/18639 0.227272727272727 1.52984339604058 0.22002621072102 0.761766421442234 GO:0034062 5'-3' RNA polymerase activity 5/2769 22/18639 0.227272727272727 1.52984339604058 0.22002621072102 0.761766421442234 GO:0097747 RNA polymerase activity 5/2769 22/18639 0.227272727272727 1.52984339604058 0.22002621072102 0.761766421442234 GO:0140784 metal ion sensor activity 5/2769 22/18639 0.227272727272727 1.52984339604058 0.22002621072102 0.761766421442234 GO:0004721 phosphoprotein phosphatase activity 30/2769 175/18639 0.171428571428571 1.15393901872775 0.223984981309782 0.773382105277173 GO:0046625 sphingolipid binding 6/2769 28/18639 0.214285714285714 1.44242377340969 0.228395527899271 0.782285217216487 GO:0046875 ephrin receptor binding 6/2769 28/18639 0.214285714285714 1.44242377340969 0.228395527899271 0.782285217216487 GO:0097718 disordered domain specific binding 6/2769 28/18639 0.214285714285714 1.44242377340969 0.228395527899271 0.782285217216487 GO:0017022 myosin binding 14/2769 76/18639 0.184210526315789 1.23997833152763 0.23187788563812 0.789988222080936 GO:0098631 cell adhesion mediator activity 14/2769 76/18639 0.184210526315789 1.23997833152763 0.23187788563812 0.789988222080936 GO:0071949 FAD binding 8/2769 40/18639 0.2 1.34626218851571 0.235587903243752 0.800498949748665 GO:0004674 protein serine/threonine kinase activity 70/2769 433/18639 0.161662817551963 1.08820269279561 0.23730944185335 0.802708491334003 GO:0005092 GDP-dissociation inhibitor activity 4/2769 17/18639 0.235294117647059 1.58383786884201 0.238744680092315 0.802708491334003 GO:0016018 cyclosporin A binding 4/2769 17/18639 0.235294117647059 1.58383786884201 0.238744680092315 0.802708491334003 GO:0045125 bioactive lipid receptor activity 4/2769 17/18639 0.235294117647059 1.58383786884201 0.238744680092315 0.802708491334003 GO:0035403 histone H3T6 kinase activity 41/2769 247/18639 0.165991902834008 1.11734311192599 0.243115855856428 0.81183301988398 GO:0030165 PDZ domain binding 15/2769 83/18639 0.180722891566265 1.21650197757444 0.244829113012479 0.81183301988398 GO:0016849 phosphorus-oxygen lyase activity 5/2769 23/18639 0.217391304347826 1.46332846577795 0.249310412088964 0.81183301988398 GO:0031681 G-protein beta-subunit binding 5/2769 23/18639 0.217391304347826 1.46332846577795 0.249310412088964 0.81183301988398 GO:0140102 catalytic activity, acting on a rRNA 5/2769 23/18639 0.217391304347826 1.46332846577795 0.249310412088964 0.81183301988398 GO:0120013 lipid transfer activity 12/2769 65/18639 0.184615384615385 1.24270355862989 0.252111742743609 0.81183301988398 GO:0051082 unfolded protein binding 21/2769 121/18639 0.173553719008264 1.16824404788553 0.253179576962458 0.81183301988398 GO:0015459 potassium channel regulator activity 11/2769 59/18639 0.186440677966102 1.25499017573498 0.254148460081553 0.81183301988398 GO:0043236 laminin binding 6/2769 29/18639 0.206896551724138 1.39268502260246 0.254553273637589 0.81183301988398 GO:0005544 calcium-dependent phospholipid binding 10/2769 53/18639 0.188679245283019 1.27005866841105 0.2558430394417 0.81183301988398 GO:0004623 phospholipase A2 activity 7/2769 35/18639 0.2 1.34626218851571 0.256900762374291 0.81183301988398 GO:0016229 steroid dehydrogenase activity 7/2769 35/18639 0.2 1.34626218851571 0.256900762374291 0.81183301988398 GO:0140566 histone reader activity 7/2769 35/18639 0.2 1.34626218851571 0.256900762374291 0.81183301988398 GO:0005504 fatty acid binding 9/2769 47/18639 0.191489361702128 1.28897443581291 0.25704421749628 0.81183301988398 GO:0001530 lipopolysaccharide binding 8/2769 41/18639 0.195121951219512 1.31342652538118 0.257520482798655 0.81183301988398 GO:0042169 SH2 domain binding 8/2769 41/18639 0.195121951219512 1.31342652538118 0.257520482798655 0.81183301988398 GO:0004032 aldose reductase (NADPH) activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0004526 ribonuclease P activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0004859 phospholipase inhibitor activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0005165 neurotrophin receptor binding 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0016273 arginine N-methyltransferase activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0016274 protein-arginine N-methyltransferase activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0016801 hydrolase activity, acting on ether bonds 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0016803 ether hydrolase activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0043047 single-stranded telomeric DNA binding 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/2769 12/18639 0.25 1.68282773564464 0.259203516887235 0.81183301988398 GO:0015085 calcium ion transmembrane transporter activity 25/2769 147/18639 0.170068027210884 1.14478077254737 0.262333270901507 0.819631512255683 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 40/2769 243/18639 0.164609053497942 1.1080347230582 0.2643293723148 0.820907978130837 GO:0035615 clathrin adaptor activity 4/2769 18/18639 0.222222222222222 1.49584687612857 0.273610861669859 0.820907978130837 GO:0140463 chromatin-protein adaptor activity 10/2769 54/18639 0.185185185185185 1.24653906344047 0.275465452424929 0.820907978130837 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/2769 48/18639 0.1875 1.26212080173348 0.277987370978796 0.820907978130837 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/2769 48/18639 0.1875 1.26212080173348 0.277987370978796 0.820907978130837 GO:0032266 phosphatidylinositol-3-phosphate binding 9/2769 48/18639 0.1875 1.26212080173348 0.277987370978796 0.820907978130837 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2769 24/18639 0.208333333333333 1.40235644637053 0.279496394384745 0.820907978130837 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 5/2769 24/18639 0.208333333333333 1.40235644637053 0.279496394384745 0.820907978130837 GO:0060229 lipase activator activity 5/2769 24/18639 0.208333333333333 1.40235644637053 0.279496394384745 0.820907978130837 GO:0004033 aldo-keto reductase (NADPH) activity 7/2769 36/18639 0.194444444444444 1.3088660166125 0.281358377972899 0.820907978130837 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 6/2769 30/18639 0.2 1.34626218851571 0.281467862802776 0.820907978130837 GO:0031210 phosphatidylcholine binding 6/2769 30/18639 0.2 1.34626218851571 0.281467862802776 0.820907978130837 GO:0033612 receptor serine/threonine kinase binding 6/2769 30/18639 0.2 1.34626218851571 0.281467862802776 0.820907978130837 GO:0048019 receptor antagonist activity 6/2769 30/18639 0.2 1.34626218851571 0.281467862802776 0.820907978130837 GO:0004676 3-phosphoinositide-dependent protein kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0004711 ribosomal protein S6 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0035175 histone H3S10 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0035979 histone H2AXS139 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0044022 histone H3S28 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0044023 histone H4S1 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0044024 histone H2AS1 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0044025 histone H2BS14 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0072354 histone H3T3 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0072371 histone H2AS121 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0072518 Rho-dependent protein serine/threonine kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0140823 histone H2BS36 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0140855 histone H3S57 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0140995 histone H2A kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0140997 histone H4 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0140998 histone H2B kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:1990244 histone H2AT120 kinase activity 40/2769 245/18639 0.163265306122449 1.09898954164548 0.282607664602419 0.820907978130837 GO:0043539 protein serine/threonine kinase activator activity 13/2769 73/18639 0.178082191780822 1.19872660621262 0.283514921349021 0.821680122733248 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 22/2769 130/18639 0.169230769230769 1.13914492874406 0.287294742566125 0.829559952826513 GO:0016500 protein-hormone receptor activity 12/2769 67/18639 0.17910447761194 1.20560793001407 0.287528976623709 0.829559952826513 GO:0004677 DNA-dependent protein kinase activity 40/2769 246/18639 0.16260162601626 1.09452210448432 0.291927234098485 0.838472616323227 GO:0140857 histone H3T45 kinase activity 40/2769 246/18639 0.16260162601626 1.09452210448432 0.291927234098485 0.838472616323227 GO:0098632 cell-cell adhesion mediator activity 10/2769 55/18639 0.181818181818182 1.22387471683246 0.295516739454635 0.844634088093291 GO:0035402 histone H3T11 kinase activity 40/2769 247/18639 0.161943319838057 1.09009084090341 0.301359384483424 0.844634088093291 GO:0016791 phosphatase activity 44/2769 273/18639 0.161172161172161 1.0848999321372 0.301887270431261 0.844634088093291 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0017154 semaphorin receptor activity 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0019104 DNA N-glycosylase activity 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0035325 Toll-like receptor binding 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0140666 annealing activity 3/2769 13/18639 0.230769230769231 1.55337944828736 0.302544985324642 0.844634088093291 GO:0048156 tau protein binding 8/2769 43/18639 0.186046511627907 1.2523369195495 0.303055823490048 0.844634088093291 GO:0043394 proteoglycan binding 7/2769 37/18639 0.189189189189189 1.27349125940675 0.306350030203027 0.844634088093291 GO:0005164 tumor necrosis factor receptor binding 6/2769 31/18639 0.193548387096774 1.30283437598294 0.308969947594749 0.844634088093291 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0005229 intracellularly calcium-gated chloride channel activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0008301 DNA binding, bending 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0016918 retinal binding 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0030506 ankyrin binding 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0042577 lipid phosphatase activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0050145 nucleoside monophosphate kinase activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0070003 threonine-type peptidase activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0097001 ceramide binding 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0141147 intracellularly calcium-gated channel activity 4/2769 19/18639 0.210526315789474 1.41711809317443 0.309237616952189 0.844634088093291 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 5/2769 25/18639 0.2 1.34626218851571 0.310341068381227 0.84556364785357 GO:0004679 AMP-activated protein kinase activity 40/2769 248/18639 0.161290322580645 1.08569531331912 0.310898109398151 0.84556364785357 GO:0061630 ubiquitin protein ligase activity 56/2769 353/18639 0.158640226628895 1.06785669344022 0.317252221323793 0.861017151516482 GO:0032813 tumor necrosis factor receptor superfamily binding 9/2769 50/18639 0.18 1.21163596966414 0.321167354680074 0.869799960560623 GO:0005109 frizzled binding 7/2769 38/18639 0.184210526315789 1.23997833152763 0.331749844199845 0.896564452362874 GO:0030515 snoRNA binding 6/2769 32/18639 0.1875 1.26212080173348 0.336891946692312 0.900957377271088 GO:0051059 NF-kappaB binding 6/2769 32/18639 0.1875 1.26212080173348 0.336891946692312 0.900957377271088 GO:0070717 poly-purine tract binding 6/2769 32/18639 0.1875 1.26212080173348 0.336891946692312 0.900957377271088 GO:0120015 sterol transfer activity 6/2769 32/18639 0.1875 1.26212080173348 0.336891946692312 0.900957377271088 GO:0140142 nucleocytoplasmic carrier activity 6/2769 32/18639 0.1875 1.26212080173348 0.336891946692312 0.900957377271088 GO:0005112 Notch binding 5/2769 26/18639 0.192307692307692 1.2944828735728 0.341608373766078 0.901282922756573 GO:0008143 poly(A) binding 5/2769 26/18639 0.192307692307692 1.2944828735728 0.341608373766078 0.901282922756573 GO:0008157 protein phosphatase 1 binding 5/2769 26/18639 0.192307692307692 1.2944828735728 0.341608373766078 0.901282922756573 GO:0008198 ferrous iron binding 5/2769 26/18639 0.192307692307692 1.2944828735728 0.341608373766078 0.901282922756573 GO:0070412 R-SMAD binding 5/2769 26/18639 0.192307692307692 1.2944828735728 0.341608373766078 0.901282922756573 GO:0030544 Hsp70 protein binding 9/2769 51/18639 0.176470588235294 1.18787840163151 0.343245410832077 0.901282922756573 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/2769 20/18639 0.2 1.34626218851571 0.345261992271152 0.901282922756573 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/2769 20/18639 0.2 1.34626218851571 0.345261992271152 0.901282922756573 GO:0061608 nuclear import signal receptor activity 4/2769 20/18639 0.2 1.34626218851571 0.345261992271152 0.901282922756573 GO:0004065 arylsulfatase activity 3/2769 14/18639 0.214285714285714 1.44242377340969 0.34616018578941 0.901282922756573 GO:0008195 phosphatidate phosphatase activity 3/2769 14/18639 0.214285714285714 1.44242377340969 0.34616018578941 0.901282922756573 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/2769 14/18639 0.214285714285714 1.44242377340969 0.34616018578941 0.901282922756573 GO:0098847 sequence-specific single stranded DNA binding 3/2769 14/18639 0.214285714285714 1.44242377340969 0.34616018578941 0.901282922756573 GO:0140311 protein sequestering activity 6/2769 33/18639 0.181818181818182 1.22387471683246 0.365070662624502 0.947895653732233 GO:0030159 signaling receptor complex adaptor activity 9/2769 52/18639 0.173076923076923 1.16503458621552 0.365542898472852 0.947895653732233 GO:0030414 peptidase inhibitor activity 27/2769 169/18639 0.159763313609467 1.07541654112202 0.372474241764624 0.961583274320661 GO:0005044 scavenger receptor activity 5/2769 27/18639 0.185185185185185 1.24653906344047 0.37307329222277 0.961583274320661 GO:0008266 poly(U) RNA binding 5/2769 27/18639 0.185185185185185 1.24653906344047 0.37307329222277 0.961583274320661 GO:0004879 nuclear receptor activity 10/2769 59/18639 0.169491525423729 1.14090015975908 0.37869981681856 0.965432893804418 GO:0031593 polyubiquitin modification-dependent protein binding 10/2769 59/18639 0.169491525423729 1.14090015975908 0.37869981681856 0.965432893804418 GO:0001846 opsonin binding 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0009975 cyclase activity 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0036122 BMP binding 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0061891 calcium ion sensor activity 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0140312 cargo adaptor activity 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:1904047 S-adenosyl-L-methionine binding 4/2769 21/18639 0.19047619047619 1.28215446525306 0.381349761331019 0.965432893804418 GO:0004532 RNA exonuclease activity 7/2769 40/18639 0.175 1.17797941495125 0.383279448190037 0.966497978605193 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/2769 40/18639 0.175 1.17797941495125 0.383279448190037 0.966497978605193 GO:0031072 heat shock protein binding 21/2769 131/18639 0.16030534351145 1.07906511293244 0.38876418057082 0.968803486793047 GO:0004953 icosanoid receptor activity 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0031005 filamin binding 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0050780 dopamine receptor binding 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0051371 muscle alpha-actinin binding 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0061578 K63-linked deubiquitinase activity 3/2769 15/18639 0.2 1.34626218851571 0.389487740592052 0.968803486793047 GO:0008175 tRNA methyltransferase activity 6/2769 34/18639 0.176470588235294 1.18787840163151 0.393349497572045 0.974624190309071 GO:0030332 cyclin binding 6/2769 34/18639 0.176470588235294 1.18787840163151 0.393349497572045 0.974624190309071 GO:0098531 ligand-modulated transcription factor activity 10/2769 60/18639 0.166666666666667 1.12188515709642 0.399911087162329 0.987176430580215 GO:0050660 flavin adenine dinucleotide binding 14/2769 86/18639 0.162790697674419 1.09579480460581 0.39995672714374 0.987176430580215 GO:0008194 UDP-glycosyltransferase activity 23/2769 145/18639 0.158620689655172 1.06772518399522 0.401162797530772 0.988249122378691 GO:0001664 G protein-coupled receptor binding 46/2769 297/18639 0.154882154882155 1.04255994396839 0.403525722038115 0.988924617428766 GO:0016866 intramolecular transferase activity 5/2769 28/18639 0.178571428571429 1.20201981117474 0.404524980119183 0.988924617428766 GO:0045499 chemorepellent activity 5/2769 28/18639 0.178571428571429 1.20201981117474 0.404524980119183 0.988924617428766 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/2769 28/18639 0.178571428571429 1.20201981117474 0.404524980119183 0.988924617428766 GO:0008013 beta-catenin binding 17/2769 106/18639 0.160377358490566 1.07954986814939 0.406547097607761 0.991974918162936 GO:0030295 protein kinase activator activity 22/2769 139/18639 0.158273381294964 1.0653873434297 0.409074114885845 0.994588331796708 GO:0016877 ligase activity, forming carbon-sulfur bonds 7/2769 41/18639 0.170731707317073 1.14924820970853 0.409170999888263 0.994588331796708 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 9/2769 54/18639 0.166666666666667 1.12188515709642 0.410484716717355 0.995891897944947 GO:0008649 rRNA methyltransferase activity 4/2769 22/18639 0.181818181818182 1.22387471683246 0.417199439244352 0.999499140373186 GO:0016881 acid-amino acid ligase activity 4/2769 22/18639 0.181818181818182 1.22387471683246 0.417199439244352 0.999499140373186 GO:0050321 tau-protein kinase activity 4/2769 22/18639 0.181818181818182 1.22387471683246 0.417199439244352 0.999499140373186 GO:0070034 telomerase RNA binding 4/2769 22/18639 0.181818181818182 1.22387471683246 0.417199439244352 0.999499140373186 GO:0140517 protein-RNA adaptor activity 4/2769 22/18639 0.181818181818182 1.22387471683246 0.417199439244352 0.999499140373186 GO:0003684 damaged DNA binding 12/2769 74/18639 0.162162162162162 1.09156393663436 0.419581799389955 0.999499140373186 GO:0048029 monosaccharide binding 12/2769 74/18639 0.162162162162162 1.09156393663436 0.419581799389955 0.999499140373186 GO:0019905 syntaxin binding 10/2769 61/18639 0.163934426229508 1.10349359714402 0.421159764311319 0.999499140373186 GO:0000175 3'-5'-RNA exonuclease activity 6/2769 35/18639 0.171428571428571 1.15393901872775 0.42158027037158 0.999499140373186 GO:0043015 gamma-tubulin binding 6/2769 35/18639 0.171428571428571 1.15393901872775 0.42158027037158 0.999499140373186 GO:0042826 histone deacetylase binding 20/2769 127/18639 0.15748031496063 1.0600489673352 0.425972693109309 0.999499140373186 GO:0005548 phospholipid transporter activity 11/2769 68/18639 0.161764705882353 1.08888853482888 0.430514707864621 0.999499140373186 GO:0004708 MAP kinase kinase activity 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0005159 insulin-like growth factor receptor binding 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0005521 lamin binding 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0016722 oxidoreductase activity, acting on metal ions 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0017070 U6 snRNA binding 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0019841 retinol binding 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0030275 LRR domain binding 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0055102 lipase inhibitor activity 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0097027 ubiquitin-protein transferase activator activity 3/2769 16/18639 0.1875 1.26212080173348 0.432056161244084 0.999499140373186 GO:0005506 iron ion binding 24/2769 154/18639 0.155844155844156 1.04903547157068 0.4336260858243 0.999499140373186 GO:0008307 structural constituent of muscle 7/2769 42/18639 0.166666666666667 1.12188515709642 0.434996761675886 0.999499140373186 GO:0051879 Hsp90 protein binding 7/2769 42/18639 0.166666666666667 1.12188515709642 0.434996761675886 0.999499140373186 GO:0004629 phospholipase C activity 5/2769 29/18639 0.172413793103448 1.16057085216872 0.435769085636182 0.999499140373186 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5/2769 29/18639 0.172413793103448 1.16057085216872 0.435769085636182 0.999499140373186 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/2769 29/18639 0.172413793103448 1.16057085216872 0.435769085636182 0.999499140373186 GO:0097472 cyclin-dependent protein kinase activity 5/2769 29/18639 0.172413793103448 1.16057085216872 0.435769085636182 0.999499140373186 GO:0031490 chromatin DNA binding 20/2769 128/18639 0.15625 1.0517673347779 0.440692460639362 0.999499140373186 GO:0019209 kinase activator activity 23/2769 148/18639 0.155405405405405 1.04608210594126 0.44217031613183 0.999499140373186 GO:0035254 glutamate receptor binding 8/2769 49/18639 0.163265306122449 1.09898954164548 0.446029197519642 0.999499140373186 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0005131 growth hormone receptor binding 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0016783 sulfurtransferase activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0019911 structural constituent of myelin sheath 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0043295 glutathione binding 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0070739 protein-glutamic acid ligase activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0070740 tubulin-glutamic acid ligase activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0098505 G-rich strand telomeric DNA binding 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0140999 histone H3K4 trimethyltransferase activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:1905394 retromer complex binding 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:1990757 ubiquitin ligase activator activity 2/2769 10/18639 0.2 1.34626218851571 0.450424026140347 0.999499140373186 GO:0017134 fibroblast growth factor binding 4/2769 23/18639 0.173913043478261 1.17066277262236 0.452544497592855 0.999499140373186 GO:0042171 lysophosphatidic acid acyltransferase activity 4/2769 23/18639 0.173913043478261 1.17066277262236 0.452544497592855 0.999499140373186 GO:0043274 phospholipase binding 4/2769 23/18639 0.173913043478261 1.17066277262236 0.452544497592855 0.999499140373186 GO:0071617 lysophospholipid acyltransferase activity 4/2769 23/18639 0.173913043478261 1.17066277262236 0.452544497592855 0.999499140373186 GO:0099186 structural constituent of postsynapse 4/2769 23/18639 0.173913043478261 1.17066277262236 0.452544497592855 0.999499140373186 GO:0008135 translation factor activity, RNA binding 13/2769 83/18639 0.156626506024096 1.05430171389784 0.464729272928857 1 GO:0005253 monoatomic anion channel activity 16/2769 103/18639 0.155339805825243 1.04564053476948 0.465186242498889 1 GO:0001965 G-protein alpha-subunit binding 5/2769 30/18639 0.166666666666667 1.12188515709642 0.466629330202863 1 GO:0008187 poly-pyrimidine tract binding 5/2769 30/18639 0.166666666666667 1.12188515709642 0.466629330202863 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 20/2769 130/18639 0.153846153846154 1.03558629885824 0.470108429784174 1 GO:0097110 scaffold protein binding 11/2769 70/18639 0.157142857142857 1.05777743383377 0.470721238823792 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0004549 tRNA-specific ribonuclease activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0004550 nucleoside diphosphate kinase activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0008429 phosphatidylethanolamine binding 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0008484 sulfuric ester hydrolase activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0016805 dipeptidase activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0030548 acetylcholine receptor regulator activity 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0031489 myosin V binding 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0036041 long-chain fatty acid binding 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0038191 neuropilin binding 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:0048038 quinone binding 3/2769 17/18639 0.176470588235294 1.18787840163151 0.473480050062321 1 GO:1990782 protein tyrosine kinase binding 18/2769 117/18639 0.153846153846154 1.03558629885824 0.475588735132125 1 GO:0019213 deacetylase activity 6/2769 37/18639 0.162162162162162 1.09156393663436 0.477355220202599 1 GO:0180051 translation factor activity 13/2769 84/18639 0.154761904761905 1.04175050301811 0.483042083097659 1 GO:0005262 calcium channel activity 20/2769 131/18639 0.152671755725191 1.02768105993566 0.484765051264058 1 GO:0001223 transcription coactivator binding 7/2769 44/18639 0.159090909090909 1.07089037722841 0.486039035216504 1 GO:0016790 thiolester hydrolase activity 7/2769 44/18639 0.159090909090909 1.07089037722841 0.486039035216504 1 GO:1902936 phosphatidylinositol bisphosphate binding 17/2769 111/18639 0.153153153153153 1.03092149571023 0.486485832705017 1 GO:0004622 lysophospholipase activity 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0005540 hyaluronic acid binding 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0015295 solute:proton symporter activity 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0030552 cAMP binding 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2769 24/18639 0.166666666666667 1.12188515709642 0.487154118234478 1 GO:0140299 molecular sensor activity 11/2769 71/18639 0.154929577464789 1.0428791601178 0.490649492765154 1 GO:0005048 signal sequence binding 8/2769 51/18639 0.156862745098039 1.05589191256134 0.493359753558162 1 GO:0016411 acylglycerol O-acyltransferase activity 5/2769 31/18639 0.161290322580645 1.08569531331912 0.496948442242885 1 GO:0016878 acid-thiol ligase activity 5/2769 31/18639 0.161290322580645 1.08569531331912 0.496948442242885 1 GO:0008408 3'-5' exonuclease activity 9/2769 58/18639 0.155172413793103 1.04451376695184 0.499709827561385 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0001851 complement component C3b binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0002162 dystroglycan binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0004016 adenylate cyclase activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0005114 type II transforming growth factor beta receptor binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0005225 volume-sensitive anion channel activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0008432 JUN kinase binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0008503 benzodiazepine receptor activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0016594 glycine binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0019107 myristoyltransferase activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0019206 nucleoside kinase activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0032794 GTPase activating protein binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0050998 nitric-oxide synthase binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0140537 transcription regulator activator activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0180030 inositol phosphate kinase activity 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:1900750 oligopeptide binding 2/2769 11/18639 0.181818181818182 1.22387471683246 0.502343359250677 1 GO:0016757 glycosyltransferase activity 40/2769 267/18639 0.149812734082397 1.00843609626645 0.503538156437796 1 GO:0000146 microfilament motor activity 6/2769 38/18639 0.157894736842105 1.06283856988082 0.504656228203115 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/2769 38/18639 0.157894736842105 1.06283856988082 0.504656228203115 1 GO:0042379 chemokine receptor binding 11/2769 72/18639 0.152777777777778 1.02839472733839 0.510399374751189 1 GO:0000900 mRNA regulatory element binding translation repressor activity 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0004706 JUN kinase kinase kinase activity 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0017128 phospholipid scramblase activity 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0099602 neurotransmitter receptor regulator activity 3/2769 18/18639 0.166666666666667 1.12188515709642 0.513453887740812 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 8/2769 52/18639 0.153846153846154 1.03558629885824 0.516599181755491 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 25/2769 167/18639 0.149700598802395 1.00768127882912 0.51690325245976 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 13/2769 86/18639 0.151162790697674 1.01752374713397 0.519269281973074 1 GO:0000030 mannosyltransferase activity 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0001848 complement binding 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0004709 MAP kinase kinase kinase activity 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0015662 P-type ion transporter activity 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0017056 structural constituent of nuclear pore 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0042974 nuclear retinoic acid receptor binding 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0120020 cholesterol transfer activity 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0140358 P-type transmembrane transporter activity 4/2769 25/18639 0.16 1.07700975081257 0.520832794397001 1 GO:0070888 E-box binding 9/2769 59/18639 0.152542372881356 1.02681014378317 0.521491629495094 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 27/2769 181/18639 0.149171270718232 1.00411820690398 0.522957828422992 1 GO:0031369 translation initiation factor binding 5/2769 32/18639 0.15625 1.0517673347779 0.52658853401151 1 GO:0004540 RNA nuclease activity 18/2769 121/18639 0.148760330578512 1.00135204104474 0.536793814937599 1 GO:0140296 general transcription initiation factor binding 8/2769 53/18639 0.150943396226415 1.01604693472884 0.539464546333898 1 GO:0008173 RNA methyltransferase activity 10/2769 67/18639 0.149253731343284 1.00467327501172 0.546174478295852 1 GO:0001221 transcription coregulator binding 17/2769 115/18639 0.147826086956522 0.995063356729003 0.549134430093313 1 GO:0005025 transforming growth factor beta receptor activity, type I 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0005026 transforming growth factor beta receptor activity, type II 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0005049 nuclear export signal receptor activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0005078 MAP-kinase scaffold activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0005095 GTPase inhibitor activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0005247 voltage-gated chloride channel activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0010853 cyclase activator activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0015368 calcium:monoatomic cation antiporter activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0016361 activin receptor activity, type I 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0016362 activin receptor activity, type II 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0017002 activin receptor activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0035251 UDP-glucosyltransferase activity 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0035259 nuclear glucocorticoid receptor binding 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0035497 cAMP response element binding 2/2769 12/18639 0.166666666666667 1.12188515709642 0.550971327723366 1 GO:0042800 histone H3K4 methyltransferase activity 3/2769 19/18639 0.157894736842105 1.06283856988082 0.55174443851368 1 GO:0030971 receptor tyrosine kinase binding 12/2769 81/18639 0.148148148148148 0.997231250752377 0.552042015513183 1 GO:0004435 phosphatidylinositol phospholipase C activity 4/2769 26/18639 0.153846153846154 1.03558629885824 0.553419052693533 1 GO:0005160 transforming growth factor beta receptor binding 4/2769 26/18639 0.153846153846154 1.03558629885824 0.553419052693533 1 GO:0019865 immunoglobulin binding 4/2769 26/18639 0.153846153846154 1.03558629885824 0.553419052693533 1 GO:0030247 polysaccharide binding 4/2769 26/18639 0.153846153846154 1.03558629885824 0.553419052693533 1 GO:0050750 low-density lipoprotein particle receptor binding 4/2769 26/18639 0.153846153846154 1.03558629885824 0.553419052693533 1 GO:0019239 deaminase activity 5/2769 33/18639 0.151515151515152 1.01989559736039 0.555431011044904 1 GO:0008276 protein methyltransferase activity 14/2769 95/18639 0.147368421052632 0.991982665222102 0.557316983372401 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/2769 40/18639 0.15 1.00969664138678 0.55756716807252 1 GO:0032451 demethylase activity 6/2769 40/18639 0.15 1.00969664138678 0.55756716807252 1 GO:0050997 quaternary ammonium group binding 6/2769 40/18639 0.15 1.00969664138678 0.55756716807252 1 GO:0099095 ligand-gated monoatomic anion channel activity 7/2769 47/18639 0.148936170212766 1.00253567229893 0.559736224062353 1 GO:0015026 coreceptor activity 9/2769 61/18639 0.147540983606557 0.993144237429622 0.564025582685155 1 GO:0003725 double-stranded RNA binding 11/2769 75/18639 0.146666666666667 0.987258938244854 0.568162320809989 1 GO:0044183 protein folding chaperone 11/2769 75/18639 0.146666666666667 0.987258938244854 0.568162320809989 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/2769 41/18639 0.146341463414634 0.985069894035885 0.583006511189821 1 GO:0140318 protein transporter activity 6/2769 41/18639 0.146341463414634 0.985069894035885 0.583006511189821 1 GO:0008376 acetylgalactosaminyltransferase activity 5/2769 34/18639 0.147058823529412 0.989898668026257 0.583376099574707 1 GO:0015020 glucuronosyltransferase activity 5/2769 34/18639 0.147058823529412 0.989898668026257 0.583376099574707 1 GO:0016831 carboxy-lyase activity 5/2769 34/18639 0.147058823529412 0.989898668026257 0.583376099574707 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 5/2769 34/18639 0.147058823529412 0.989898668026257 0.583376099574707 1 GO:0005385 zinc ion transmembrane transporter activity 4/2769 27/18639 0.148148148148148 0.997231250752377 0.584783532775405 1 GO:0016279 protein-lysine N-methyltransferase activity 10/2769 69/18639 0.144927536231884 0.97555231051863 0.585684552893224 1 GO:0005254 chloride channel activity 12/2769 83/18639 0.144578313253012 0.973201582059549 0.58798371815638 1 GO:0000339 RNA cap binding 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0005326 neurotransmitter transmembrane transporter activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0010851 cyclase regulator activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0016408 C-acyltransferase activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0043024 ribosomal small subunit binding 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0052745 inositol phosphate phosphatase activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0140664 ATP-dependent DNA damage sensor activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0140939 histone H4 methyltransferase activity 3/2769 20/18639 0.15 1.00969664138678 0.58818251726236 1 GO:0004535 poly(A)-specific ribonuclease activity 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0005542 folic acid binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0008035 high-density lipoprotein particle binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0009982 pseudouridine synthase activity 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0030955 potassium ion binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0043560 insulin receptor substrate binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0046975 histone H3K36 methyltransferase activity 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0070123 transforming growth factor beta receptor activity, type III 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0071837 HMG box domain binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0089720 caspase binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0097157 pre-mRNA intronic binding 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0140852 histone ubiquitin ligase activity 2/2769 13/18639 0.153846153846154 1.03558629885824 0.596139753614043 1 GO:0016278 lysine N-methyltransferase activity 10/2769 70/18639 0.142857142857143 0.961615848939793 0.604845105238129 1 GO:0016782 transferase activity, transferring sulphur-containing groups 10/2769 70/18639 0.142857142857143 0.961615848939793 0.604845105238129 1 GO:0019894 kinesin binding 6/2769 42/18639 0.142857142857143 0.961615848939793 0.607674802775477 1 GO:0042056 chemoattractant activity 6/2769 42/18639 0.142857142857143 0.961615848939793 0.607674802775477 1 GO:0019789 SUMO transferase activity 4/2769 28/18639 0.142857142857143 0.961615848939793 0.614826624884775 1 GO:0051119 sugar transmembrane transporter activity 4/2769 28/18639 0.142857142857143 0.961615848939793 0.614826624884775 1 GO:0051393 alpha-actinin binding 4/2769 28/18639 0.142857142857143 0.961615848939793 0.614826624884775 1 GO:0004866 endopeptidase inhibitor activity 23/2769 161/18639 0.142857142857143 0.961615848939793 0.614881481951511 1 GO:0008373 sialyltransferase activity 3/2769 21/18639 0.142857142857143 0.961615848939793 0.622654643250917 1 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2769 21/18639 0.142857142857143 0.961615848939793 0.622654643250917 1 GO:0019200 carbohydrate kinase activity 3/2769 21/18639 0.142857142857143 0.961615848939793 0.622654643250917 1 GO:0070182 DNA polymerase binding 3/2769 21/18639 0.142857142857143 0.961615848939793 0.622654643250917 1 GO:0048020 CCR chemokine receptor binding 7/2769 50/18639 0.14 0.942383531960997 0.628292365750279 1 GO:0016758 hexosyltransferase activity 28/2769 197/18639 0.142131979695431 0.95673455021421 0.631242958630386 1 GO:0008375 acetylglucosaminyltransferase activity 6/2769 43/18639 0.13953488372093 0.939252689662123 0.631516347425407 1 GO:0008168 methyltransferase activity 29/2769 204/18639 0.142156862745098 0.956902045758715 0.632078572421648 1 GO:0030246 carbohydrate binding 40/2769 280/18639 0.142857142857143 0.961615848939793 0.632285354474589 1 GO:0004705 JUN kinase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0005161 platelet-derived growth factor receptor binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0005313 L-glutamate transmembrane transporter activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0015926 glucosidase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0019763 immunoglobulin receptor activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0019992 diacylglycerol binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0030983 mismatched DNA binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0031404 chloride ion binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0032454 histone H3K9 demethylase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0042813 Wnt receptor activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0046030 inositol trisphosphate phosphatase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0061665 SUMO ligase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0071933 Arp2/3 complex binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0098599 palmitoyl hydrolase activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0098821 BMP receptor activity 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:1990825 sequence-specific mRNA binding 2/2769 14/18639 0.142857142857143 0.961615848939793 0.637803014918149 1 GO:0033293 monocarboxylic acid binding 11/2769 79/18639 0.139240506329114 0.937271143903342 0.640401644959893 1 GO:0061135 endopeptidase regulator activity 26/2769 184/18639 0.141304347826087 0.951163502755664 0.641096223402203 1 GO:0035250 UDP-galactosyltransferase activity 4/2769 29/18639 0.137931034482759 0.928456681734972 0.64347583116455 1 GO:0160215 deacylase activity 9/2769 65/18639 0.138461538461538 0.932027668972414 0.643729880913337 1 GO:0016779 nucleotidyltransferase activity 19/2769 136/18639 0.139705882352941 0.940403734624944 0.651200722391576 1 GO:0019842 vitamin binding 21/2769 150/18639 0.14 0.942383531960997 0.651205334093064 1 GO:0008970 phospholipase A1 activity 3/2769 22/18639 0.136363636363636 0.917906037624347 0.655094938620375 1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/2769 22/18639 0.136363636363636 0.917906037624347 0.655094938620375 1 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2769 22/18639 0.136363636363636 0.917906037624347 0.655094938620375 1 GO:0033691 sialic acid binding 3/2769 22/18639 0.136363636363636 0.917906037624347 0.655094938620375 1 GO:0061133 endopeptidase activator activity 3/2769 22/18639 0.136363636363636 0.917906037624347 0.655094938620375 1 GO:0004521 RNA endonuclease activity 10/2769 73/18639 0.136986301369863 0.922097389394322 0.659578726394668 1 GO:0022829 wide pore channel activity 5/2769 37/18639 0.135135135135135 0.909636613861966 0.66109376970535 1 GO:0042805 actinin binding 5/2769 37/18639 0.135135135135135 0.909636613861966 0.66109376970535 1 GO:0004620 phospholipase activity 15/2769 109/18639 0.137614678899083 0.926327193932828 0.667034318036621 1 GO:0016769 transferase activity, transferring nitrogenous groups 4/2769 30/18639 0.133333333333333 0.89750812567714 0.670682985158656 1 GO:0051721 protein phosphatase 2A binding 4/2769 30/18639 0.133333333333333 0.89750812567714 0.670682985158656 1 GO:0098918 structural constituent of synapse 4/2769 30/18639 0.133333333333333 0.89750812567714 0.670682985158656 1 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0140791 histone H2AXS140 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2769 81/18639 0.135802469135802 0.914128646523013 0.673979668215788 1 GO:0016741 transferase activity, transferring one-carbon groups 30/2769 215/18639 0.13953488372093 0.939252689662123 0.674770704168424 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2769 15/18639 0.133333333333333 0.89750812567714 0.676005364814472 1 GO:0015929 hexosaminidase activity 2/2769 15/18639 0.133333333333333 0.89750812567714 0.676005364814472 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2769 15/18639 0.133333333333333 0.89750812567714 0.676005364814472 1 GO:0030553 cGMP binding 2/2769 15/18639 0.133333333333333 0.89750812567714 0.676005364814472 1 GO:0140161 monocarboxylate:sodium symporter activity 2/2769 15/18639 0.133333333333333 0.89750812567714 0.676005364814472 1 GO:0140303 intramembrane lipid transporter activity 6/2769 45/18639 0.133333333333333 0.89750812567714 0.676550771529156 1 GO:0070577 lysine-acetylated histone binding 3/2769 23/18639 0.130434782608696 0.877997079466767 0.685477504774503 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/2769 23/18639 0.130434782608696 0.877997079466767 0.685477504774503 1 GO:0003727 single-stranded RNA binding 12/2769 89/18639 0.134831460674157 0.907592486639804 0.687186966452988 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/2769 82/18639 0.134146341463415 0.902980736199561 0.690063817065995 1 GO:0033549 MAP kinase phosphatase activity 11/2769 82/18639 0.134146341463415 0.902980736199561 0.690063817065995 1 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2769 31/18639 0.129032258064516 0.868556250655297 0.696421435960993 1 GO:0070325 lipoprotein particle receptor binding 4/2769 31/18639 0.129032258064516 0.868556250655297 0.696421435960993 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2769 46/18639 0.130434782608696 0.877997079466767 0.697684622229102 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/2769 83/18639 0.132530120481928 0.892101450221253 0.705659387732742 1 GO:0000217 DNA secondary structure binding 5/2769 39/18639 0.128205128205128 0.862988582381865 0.707351194776156 1 GO:0003688 DNA replication origin binding 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0004707 MAP kinase activity 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0005024 transforming growth factor beta receptor activity 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0008296 3'-5'-DNA exonuclease activity 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0022858 alanine transmembrane transporter activity 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0070411 I-SMAD binding 2/2769 16/18639 0.125 0.841413867822319 0.710855251038813 1 GO:0030527 structural constituent of chromatin 13/2769 98/18639 0.13265306122449 0.89292900258695 0.713568422532429 1 GO:0042626 ATPase-coupled transmembrane transporter activity 13/2769 98/18639 0.13265306122449 0.89292900258695 0.713568422532429 1 GO:0015149 hexose transmembrane transporter activity 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0019957 C-C chemokine binding 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0030215 semaphorin receptor binding 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0050699 WW domain binding 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0055056 D-glucose transmembrane transporter activity 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0070300 phosphatidic acid binding 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0140033 acetylation-dependent protein binding 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0140612 DNA damage sensor activity 3/2769 24/18639 0.125 0.841413867822319 0.713809417137364 1 GO:0043495 protein-membrane adaptor activity 6/2769 47/18639 0.127659574468085 0.859316290541942 0.717872192692528 1 GO:0140938 histone H3 methyltransferase activity 6/2769 47/18639 0.127659574468085 0.859316290541942 0.717872192692528 1 GO:0008378 galactosyltransferase activity 4/2769 32/18639 0.125 0.841413867822319 0.720683279096633 1 GO:0015106 bicarbonate transmembrane transporter activity 4/2769 32/18639 0.125 0.841413867822319 0.720683279096633 1 GO:0004527 exonuclease activity 11/2769 84/18639 0.130952380952381 0.881481194861477 0.720755817427705 1 GO:0017018 myosin phosphatase activity 11/2769 84/18639 0.130952380952381 0.881481194861477 0.720755817427705 1 GO:0015297 antiporter activity 18/2769 135/18639 0.133333333333333 0.89750812567714 0.726730048914869 1 GO:0008374 O-acyltransferase activity 7/2769 55/18639 0.127272727272727 0.856712301782724 0.727881544081495 1 GO:0005319 lipid transporter activity 24/2769 178/18639 0.134831460674157 0.907592486639804 0.728445808173146 1 GO:0061791 GTPase motor activity 5/2769 40/18639 0.125 0.841413867822319 0.728748912876676 1 GO:1990606 membrane scission GTPase motor activity 5/2769 40/18639 0.125 0.841413867822319 0.728748912876676 1 GO:0140104 molecular carrier activity 34/2769 249/18639 0.136546184738956 0.919134827500685 0.730275425015166 1 GO:0005251 delayed rectifier potassium channel activity 3/2769 25/18639 0.12 0.807757313109426 0.740124411147413 1 GO:0005537 D-mannose binding 3/2769 25/18639 0.12 0.807757313109426 0.740124411147413 1 GO:0008483 transaminase activity 3/2769 25/18639 0.12 0.807757313109426 0.740124411147413 1 GO:0015271 outward rectifier potassium channel activity 3/2769 25/18639 0.12 0.807757313109426 0.740124411147413 1 GO:0047617 fatty acyl-CoA hydrolase activity 3/2769 25/18639 0.12 0.807757313109426 0.740124411147413 1 GO:0004659 prenyltransferase activity 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0017110 nucleoside diphosphate phosphatase activity 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0032183 SUMO binding 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0046965 nuclear retinoid X receptor binding 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0070403 NAD+ binding 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:1990226 histone methyltransferase binding 2/2769 17/18639 0.117647058823529 0.791918934421006 0.742505277835678 1 GO:0030296 protein tyrosine kinase activator activity 4/2769 33/18639 0.121212121212121 0.815916477888309 0.74347669537963 1 GO:0140030 modification-dependent protein binding 23/2769 173/18639 0.132947976878613 0.894914171556686 0.749895624215205 1 GO:0005227 calcium-activated cation channel activity 3/2769 26/18639 0.115384615384615 0.776689724143679 0.764477283989224 1 GO:0015145 monosaccharide transmembrane transporter activity 3/2769 26/18639 0.115384615384615 0.776689724143679 0.764477283989224 1 GO:0016289 acyl-CoA hydrolase activity 3/2769 26/18639 0.115384615384615 0.776689724143679 0.764477283989224 1 GO:0052742 phosphatidylinositol kinase activity 3/2769 26/18639 0.115384615384615 0.776689724143679 0.764477283989224 1 GO:0070006 metalloaminopeptidase activity 3/2769 26/18639 0.115384615384615 0.776689724143679 0.764477283989224 1 GO:0140767 enzyme-substrate adaptor activity 18/2769 139/18639 0.129496402877698 0.871680553715208 0.770933838467293 1 GO:0000400 four-way junction DNA binding 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0004970 glutamate-gated receptor activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0008525 phosphatidylcholine transporter activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0015280 ligand-gated sodium channel activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0016854 racemase and epimerase activity 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0034185 apolipoprotein binding 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:1901611 phosphatidylglycerol binding 2/2769 18/18639 0.111111111111111 0.747923438064283 0.771136701597537 1 GO:0015605 organophosphate ester transmembrane transporter activity 6/2769 50/18639 0.12 0.807757313109426 0.772715722249101 1 GO:0004197 cysteine-type endopeptidase activity 11/2769 88/18639 0.125 0.841413867822319 0.776027319714145 1 GO:0001618 virus receptor activity 10/2769 81/18639 0.123456790123457 0.831026042293648 0.782167284874776 1 GO:0008235 metalloexopeptidase activity 8/2769 66/18639 0.121212121212121 0.815916477888309 0.783586161302424 1 GO:0005343 organic acid:sodium symporter activity 4/2769 35/18639 0.114285714285714 0.769292679151834 0.784756521535778 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/2769 43/18639 0.116279069767442 0.782710574718436 0.786057597587459 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2769 43/18639 0.116279069767442 0.782710574718436 0.786057597587459 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/2769 27/18639 0.111111111111111 0.747923438064283 0.786939002890951 1 GO:0008320 protein transmembrane transporter activity 3/2769 27/18639 0.111111111111111 0.747923438064283 0.786939002890951 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2769 27/18639 0.111111111111111 0.747923438064283 0.786939002890951 1 GO:0035255 ionotropic glutamate receptor binding 3/2769 27/18639 0.111111111111111 0.747923438064283 0.786939002890951 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/2769 27/18639 0.111111111111111 0.747923438064283 0.786939002890951 1 GO:0036002 pre-mRNA binding 7/2769 59/18639 0.11864406779661 0.798630111831353 0.79309519217749 1 GO:0140272 exogenous protein binding 10/2769 82/18639 0.121951219512195 0.820891578363238 0.794959433181551 1 GO:0015245 fatty acid transmembrane transporter activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0022821 solute:potassium antiporter activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0031420 alkali metal ion binding 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0034987 immunoglobulin receptor binding 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0046527 glucosyltransferase activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0046624 sphingolipid transporter activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:1990380 K48-linked deubiquitinase activity 2/2769 19/18639 0.105263157894737 0.708559046587216 0.796947556077991 1 GO:0042054 histone methyltransferase activity 8/2769 67/18639 0.119402985074627 0.803738620009379 0.797583001569751 1 GO:0001094 TFIID-class transcription factor complex binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0003796 lysozyme activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0004382 GDP phosphatase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0004983 neuropeptide Y receptor activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0008239 dipeptidyl-peptidase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0015187 glycine transmembrane transporter activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0015203 polyamine transmembrane transporter activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0015643 toxic substance binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0016427 tRNA (cytidine) methyltransferase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0019531 oxalate transmembrane transporter activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0030957 Tat protein binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0031419 cobalamin binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0031996 thioesterase binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0032356 oxidized DNA binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0043121 neurotrophin binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0043422 protein kinase B binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0051864 histone H3K36 demethylase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0070097 delta-catenin binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0140940 histone H2A methyltransferase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:1990763 arrestin family protein binding 1/2769 10/18639 0.1 0.673131094257855 0.799847890487292 1 GO:0005080 protein kinase C binding 6/2769 52/18639 0.115384615384615 0.776689724143679 0.804584394396052 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2769 60/18639 0.116666666666667 0.785319609967497 0.807400122270666 1 GO:0036408 histone H3K14 acetyltransferase activity 3/2769 28/18639 0.107142857142857 0.721211886704844 0.807592488251692 1 GO:0051019 mitogen-activated protein kinase binding 3/2769 28/18639 0.107142857142857 0.721211886704844 0.807592488251692 1 GO:0051959 dynein light intermediate chain binding 3/2769 28/18639 0.107142857142857 0.721211886704844 0.807592488251692 1 GO:0141052 histone H3 demethylase activity 3/2769 28/18639 0.107142857142857 0.721211886704844 0.807592488251692 1 GO:0008009 chemokine activity 5/2769 45/18639 0.111111111111111 0.747923438064283 0.81872255876316 1 GO:0046915 transition metal ion transmembrane transporter activity 5/2769 45/18639 0.111111111111111 0.747923438064283 0.81872255876316 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/2769 53/18639 0.113207547169811 0.762035201046628 0.819160018680532 1 GO:0001614 purinergic nucleotide receptor activity 2/2769 20/18639 0.1 0.673131094257855 0.820143671501949 1 GO:0016502 nucleotide receptor activity 2/2769 20/18639 0.1 0.673131094257855 0.820143671501949 1 GO:0023023 MHC protein complex binding 4/2769 37/18639 0.108108108108108 0.727709291089573 0.820557364807798 1 GO:0030280 structural constituent of skin epidermis 4/2769 37/18639 0.108108108108108 0.727709291089573 0.820557364807798 1 GO:0002039 p53 binding 8/2769 69/18639 0.115942028985507 0.780441848414904 0.823517070486677 1 GO:0010484 histone H3 acetyltransferase activity 3/2769 29/18639 0.103448275862069 0.696342511301229 0.826529025607901 1 GO:0016298 lipase activity 16/2769 130/18639 0.123076923076923 0.828469039086591 0.826689265205276 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0005536 D-glucose binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0008172 S-methyltransferase activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0019864 IgG binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0032050 clathrin heavy chain binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0043522 leucine zipper domain binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0045294 alpha-catenin binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0048407 platelet-derived growth factor binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0070697 activin receptor binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0140031 phosphorylation-dependent protein binding 1/2769 11/18639 0.0909090909090909 0.611937358416232 0.829598343610953 1 GO:0015179 L-amino acid transmembrane transporter activity 7/2769 62/18639 0.112903225806452 0.759986719323384 0.833708033059192 1 GO:0005125 cytokine activity 30/2769 234/18639 0.128205128205128 0.862988582381865 0.834708093739469 1 GO:0005501 retinoid binding 4/2769 38/18639 0.105263157894737 0.708559046587216 0.83652923978416 1 GO:0019840 isoprenoid binding 4/2769 38/18639 0.105263157894737 0.708559046587216 0.83652923978416 1 GO:0042277 peptide binding 32/2769 249/18639 0.1285140562249 0.865068072941821 0.837693868359818 1 GO:0070851 growth factor receptor binding 17/2769 139/18639 0.122302158273381 0.823253856286585 0.839903640809653 1 GO:0015125 bile acid transmembrane transporter activity 2/2769 21/18639 0.0952380952380952 0.641077232626528 0.840931990265215 1 GO:0035613 RNA stem-loop binding 2/2769 21/18639 0.0952380952380952 0.641077232626528 0.840931990265215 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2769 21/18639 0.0952380952380952 0.641077232626528 0.840931990265215 1 GO:0051010 microtubule plus-end binding 2/2769 21/18639 0.0952380952380952 0.641077232626528 0.840931990265215 1 GO:0051428 peptide hormone receptor binding 2/2769 21/18639 0.0952380952380952 0.641077232626528 0.840931990265215 1 GO:0022839 monoatomic ion-gated channel activity 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0032452 histone demethylase activity 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0043995 histone H4K5 acetyltransferase activity 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0043996 histone H4K8 acetyltransferase activity 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0043997 histone H4K12 acetyltransferase activity 3/2769 30/18639 0.1 0.673131094257855 0.843845252324484 1 GO:0004867 serine-type endopeptidase inhibitor activity 11/2769 95/18639 0.115789473684211 0.779414951245937 0.853178805470567 1 GO:0000340 RNA 7-methylguanosine cap binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0003720 telomerase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0003995 acyl-CoA dehydrogenase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0004000 adenosine deaminase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0004126 cytidine deaminase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0005436 sodium:phosphate symporter activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0008179 adenylate cyclase binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0008504 monoamine transmembrane transporter activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0015269 calcium-activated potassium channel activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0016208 AMP binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0016840 carbon-nitrogen lyase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0034452 dynactin binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0042301 phosphate ion binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0045295 gamma-catenin binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0097677 STAT family protein binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0140900 chloride:bicarbonate antiporter activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:1990459 transferrin receptor binding 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:1990817 poly(A) RNA polymerase activity 1/2769 12/18639 0.0833333333333333 0.560942578548212 0.854928072328007 1 GO:0004722 protein serine/threonine phosphatase activity 12/2769 103/18639 0.116504854368932 0.784230401077112 0.85586795141124 1 GO:0030170 pyridoxal phosphate binding 6/2769 56/18639 0.107142857142857 0.721211886704844 0.857753929336618 1 GO:0032931 histone H3K56 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0043992 histone H3K9 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0043993 histone H3K18 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0043994 histone H3K23 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0043999 histone H2AK5 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044012 histone H2AK9 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044014 histone H2BK5 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044015 histone H2BK12 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044016 histone H3K4 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044017 histone H3K27 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0044018 histone H3K36 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0046972 histone H4K16 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0140908 histone H3K122 acetyltransferase activity 2/2769 22/18639 0.0909090909090909 0.611937358416232 0.8595156954297 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/2769 31/18639 0.0967741935483871 0.651417187991472 0.859640661220572 1 GO:0140457 protein demethylase activity 3/2769 31/18639 0.0967741935483871 0.651417187991472 0.859640661220572 1 GO:0005216 monoatomic ion channel activity 59/2769 448/18639 0.131696428571429 0.886489610741371 0.861304165017474 1 GO:0005126 cytokine receptor binding 35/2769 275/18639 0.127272727272727 0.856712301782724 0.862074374249255 1 GO:0015144 carbohydrate transmembrane transporter activity 4/2769 40/18639 0.1 0.673131094257855 0.864908392933627 1 GO:0140662 ATP-dependent protein folding chaperone 4/2769 40/18639 0.1 0.673131094257855 0.864908392933627 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2769 57/18639 0.105263157894737 0.708559046587216 0.869006638883751 1 GO:0070279 vitamin B6 binding 6/2769 57/18639 0.105263157894737 0.708559046587216 0.869006638883751 1 GO:0042393 histone binding 31/2769 247/18639 0.125506072874494 0.844820401700141 0.869014310457836 1 GO:0022884 macromolecule transmembrane transporter activity 3/2769 32/18639 0.09375 0.631060400866739 0.8740155628196 1 GO:0071813 lipoprotein particle binding 3/2769 32/18639 0.09375 0.631060400866739 0.8740155628196 1 GO:0071814 protein-lipid complex binding 3/2769 32/18639 0.09375 0.631060400866739 0.8740155628196 1 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0005158 insulin receptor binding 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0005283 amino acid:sodium symporter activity 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0016493 C-C chemokine receptor activity 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0044013 histone H2B acetyltransferase activity 2/2769 23/18639 0.0869565217391304 0.585331386311178 0.876090761206385 1 GO:0003964 RNA-directed DNA polymerase activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0005172 vascular endothelial growth factor receptor binding 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0008417 fucosyltransferase activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0045159 myosin II binding 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0061459 L-arginine transmembrane transporter activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0071714 icosanoid transmembrane transporter activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2769 13/18639 0.0769230769230769 0.517793149429119 0.87649376555417 1 GO:0035064 methylated histone binding 8/2769 74/18639 0.108108108108108 0.727709291089573 0.877053618317948 1 GO:0140828 metal cation:monoatomic cation antiporter activity 4/2769 41/18639 0.0975609756097561 0.65671326269059 0.877440012373916 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 14/2769 122/18639 0.114754098360656 0.772445518000817 0.884116506150855 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/2769 91/18639 0.10989010989011 0.739704499184456 0.886073775878726 1 GO:0004520 DNA endonuclease activity 4/2769 42/18639 0.0952380952380952 0.641077232626528 0.88895078369981 1 GO:0035198 miRNA binding 4/2769 42/18639 0.0952380952380952 0.641077232626528 0.88895078369981 1 GO:0008237 metallopeptidase activity 22/2769 184/18639 0.119565217391304 0.80483065617787 0.890508735750309 1 GO:0005315 phosphate transmembrane transporter activity 2/2769 24/18639 0.0833333333333333 0.560942578548212 0.890843610667205 1 GO:0043998 histone H2A acetyltransferase activity 2/2769 24/18639 0.0833333333333333 0.560942578548212 0.890843610667205 1 GO:0070840 dynein complex binding 2/2769 24/18639 0.0833333333333333 0.560942578548212 0.890843610667205 1 GO:0046982 protein heterodimerization activity 47/2769 369/18639 0.127371273712737 0.857375648512715 0.892421651691508 1 GO:0140034 methylation-dependent protein binding 8/2769 76/18639 0.105263157894737 0.708559046587216 0.894352885778852 1 GO:0008331 high voltage-gated calcium channel activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0008392 arachidonate epoxygenase activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0008494 translation activator activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0015386 potassium:proton antiporter activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0042043 neurexin family protein binding 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0061783 peptidoglycan muralytic activity 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:0070742 C2H2 zinc finger domain binding 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:1901612 cardiolipin binding 1/2769 14/18639 0.0714285714285714 0.480807924469896 0.894854592526172 1 GO:1990841 promoter-specific chromatin binding 7/2769 68/18639 0.102941176470588 0.69292906761838 0.895795815840128 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/2769 34/18639 0.0882352941176471 0.593939200815754 0.898899708409725 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/2769 34/18639 0.0882352941176471 0.593939200815754 0.898899708409725 1 GO:0051427 hormone receptor binding 3/2769 34/18639 0.0882352941176471 0.593939200815754 0.898899708409725 1 GO:0090482 vitamin transmembrane transporter activity 3/2769 34/18639 0.0882352941176471 0.593939200815754 0.898899708409725 1 GO:0005245 voltage-gated calcium channel activity 4/2769 43/18639 0.0930232558139535 0.626168459774749 0.899503930993385 1 GO:0004518 nuclease activity 25/2769 209/18639 0.119617224880383 0.8051807347582 0.902823960409168 1 GO:0008139 nuclear localization sequence binding 2/2769 25/18639 0.08 0.538504875406284 0.903949628016752 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/2769 25/18639 0.08 0.538504875406284 0.903949628016752 1 GO:0008509 monoatomic anion transmembrane transporter activity 17/2769 149/18639 0.114093959731544 0.768001919623056 0.907559979423749 1 GO:0016410 N-acyltransferase activity 10/2769 94/18639 0.106382978723404 0.716096908784952 0.907833308545228 1 GO:0010485 histone H4 acetyltransferase activity 3/2769 35/18639 0.0857142857142857 0.576969509363876 0.909600632179157 1 GO:0004089 carbonate dehydratase activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0004559 alpha-mannosidase activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0005041 low-density lipoprotein particle receptor activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0008242 omega peptidase activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0015116 sulfate transmembrane transporter activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0140776 protein-containing complex destabilizing activity 1/2769 15/18639 0.0666666666666667 0.44875406283857 0.910486680219865 1 GO:0008146 sulfotransferase activity 5/2769 53/18639 0.0943396226415094 0.635029334205523 0.911292461560913 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/2769 53/18639 0.0943396226415094 0.635029334205523 0.911292461560913 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/2769 70/18639 0.1 0.673131094257855 0.911564670008916 1 GO:0004519 endonuclease activity 14/2769 127/18639 0.110236220472441 0.742034277134643 0.91501851259621 1 GO:0019783 ubiquitin-like protein peptidase activity 14/2769 127/18639 0.110236220472441 0.742034277134643 0.91501851259621 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0004529 DNA exonuclease activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0004950 chemokine receptor activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0008066 glutamate receptor activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0015216 purine nucleotide transmembrane transporter activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0051139 metal cation:proton antiporter activity 2/2769 26/18639 0.0769230769230769 0.517793149429119 0.91557232335238 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/2769 36/18639 0.0833333333333333 0.560942578548212 0.919262684447339 1 GO:0045505 dynein intermediate chain binding 3/2769 36/18639 0.0833333333333333 0.560942578548212 0.919262684447339 1 GO:0017069 snRNA binding 5/2769 54/18639 0.0925925925925926 0.623269531720236 0.919295630015848 1 GO:1901682 sulfur compound transmembrane transporter activity 6/2769 63/18639 0.0952380952380952 0.641077232626528 0.921928989570965 1 GO:0005261 monoatomic cation channel activity 42/2769 341/18639 0.12316715542522 0.829076421080056 0.923168209482564 1 GO:0005149 interleukin-1 receptor binding 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0008391 arachidonate monooxygenase activity 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0015385 sodium:proton antiporter activity 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0015923 mannosidase activity 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0140327 flippase activity 1/2769 16/18639 0.0625 0.420706933911159 0.923795442165268 1 GO:0015108 chloride transmembrane transporter activity 13/2769 121/18639 0.107438016528926 0.723198696310092 0.925041150370358 1 GO:0004252 serine-type endopeptidase activity 20/2769 176/18639 0.113636363636364 0.764921698020289 0.925710504491977 1 GO:0005104 fibroblast growth factor receptor binding 2/2769 27/18639 0.0740740740740741 0.498615625376189 0.925862988989294 1 GO:0003774 cytoskeletal motor activity 17/2769 153/18639 0.111111111111111 0.747923438064283 0.927072068559587 1 GO:0004536 DNA nuclease activity 6/2769 64/18639 0.09375 0.631060400866739 0.928637390336953 1 GO:0015101 organic cation transmembrane transporter activity 8/2769 81/18639 0.0987654320987654 0.664820833834918 0.928857134289974 1 GO:0140359 ABC-type transporter activity 4/2769 47/18639 0.0851063829787234 0.572877527027962 0.933361847257399 1 GO:0170055 lipid transmembrane transporter activity 5/2769 56/18639 0.0892857142857143 0.60100990558737 0.933408452315772 1 GO:0101005 deubiquitinase activity 12/2769 115/18639 0.104347826086957 0.702397663573414 0.934804709725483 1 GO:0038024 cargo receptor activity 6/2769 65/18639 0.0923076923076923 0.621351779314943 0.934831871625686 1 GO:0005242 inward rectifier potassium channel activity 2/2769 28/18639 0.0714285714285714 0.480807924469896 0.934960719815263 1 GO:0009881 photoreceptor activity 1/2769 17/18639 0.0588235294117647 0.395959467210503 0.935126077435868 1 GO:0030169 low-density lipoprotein particle binding 1/2769 17/18639 0.0588235294117647 0.395959467210503 0.935126077435868 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2769 17/18639 0.0588235294117647 0.395959467210503 0.935126077435868 1 GO:0045236 CXCR chemokine receptor binding 1/2769 17/18639 0.0588235294117647 0.395959467210503 0.935126077435868 1 GO:0043531 ADP binding 3/2769 38/18639 0.0789473684210526 0.531419284940412 0.9358099262915 1 GO:0008188 neuropeptide receptor activity 4/2769 48/18639 0.0833333333333333 0.560942578548212 0.940026236039557 1 GO:0140693 molecular condensate scaffold activity 4/2769 48/18639 0.0833333333333333 0.560942578548212 0.940026236039557 1 GO:0004181 metallocarboxypeptidase activity 2/2769 29/18639 0.0689655172413793 0.464228340867486 0.942992697163957 1 GO:0005416 amino acid:monoatomic cation symporter activity 2/2769 29/18639 0.0689655172413793 0.464228340867486 0.942992697163957 1 GO:0003746 translation elongation factor activity 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0008409 5'-3' exonuclease activity 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0022851 GABA-gated chloride ion channel activity 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0030228 lipoprotein particle receptor activity 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0032393 MHC class I receptor activity 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0050811 GABA receptor binding 1/2769 18/18639 0.0555555555555556 0.373961719032142 0.944772511308711 1 GO:0061980 regulatory RNA binding 5/2769 58/18639 0.0862068965517241 0.580285426084358 0.945270148477555 1 GO:0020037 heme binding 15/2769 142/18639 0.105633802816901 0.711053972807593 0.946329061407826 1 GO:0004222 metalloendopeptidase activity 11/2769 110/18639 0.1 0.673131094257855 0.948258748157158 1 GO:0004177 aminopeptidase activity 3/2769 40/18639 0.075 0.504848320693391 0.949172886776694 1 GO:0008238 exopeptidase activity 10/2769 102/18639 0.0980392156862745 0.659932445350838 0.949446967900515 1 GO:0015171 amino acid transmembrane transporter activity 10/2769 102/18639 0.0980392156862745 0.659932445350838 0.949446967900515 1 GO:0015215 nucleotide transmembrane transporter activity 2/2769 30/18639 0.0666666666666667 0.44875406283857 0.950074657509633 1 GO:0140223 general transcription initiation factor activity 6/2769 68/18639 0.0882352941176471 0.593939200815754 0.950645150129135 1 GO:0042562 hormone binding 9/2769 94/18639 0.0957446808510638 0.644487217906457 0.951037390366182 1 GO:0046906 tetrapyrrole binding 16/2769 152/18639 0.105263157894737 0.708559046587216 0.952919795281522 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/2769 19/18639 0.0526315789473684 0.354279523293608 0.952985008821528 1 GO:0004890 GABA-A receptor activity 1/2769 19/18639 0.0526315789473684 0.354279523293608 0.952985008821528 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/2769 19/18639 0.0526315789473684 0.354279523293608 0.952985008821528 1 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2769 19/18639 0.0526315789473684 0.354279523293608 0.952985008821528 1 GO:0042834 peptidoglycan binding 1/2769 19/18639 0.0526315789473684 0.354279523293608 0.952985008821528 1 GO:0004175 endopeptidase activity 49/2769 405/18639 0.120987654320988 0.814405521447775 0.953376221731591 1 GO:0001727 lipid kinase activity 3/2769 41/18639 0.0731707317073171 0.492534947017943 0.954836008440071 1 GO:0042287 MHC protein binding 3/2769 41/18639 0.0731707317073171 0.492534947017943 0.954836008440071 1 GO:0005184 neuropeptide hormone activity 2/2769 31/18639 0.0645161290322581 0.434278125327648 0.956311484839913 1 GO:0008327 methyl-CpG binding 2/2769 31/18639 0.0645161290322581 0.434278125327648 0.956311484839913 1 GO:0072349 modified amino acid transmembrane transporter activity 2/2769 31/18639 0.0645161290322581 0.434278125327648 0.956311484839913 1 GO:0004896 cytokine receptor activity 9/2769 96/18639 0.09375 0.631060400866739 0.958462728740746 1 GO:0016407 acetyltransferase activity 9/2769 96/18639 0.09375 0.631060400866739 0.958462728740746 1 GO:0015291 secondary active transmembrane transporter activity 33/2769 287/18639 0.114982578397213 0.773983488171053 0.958762944985708 1 GO:0004402 histone acetyltransferase activity 3/2769 42/18639 0.0714285714285714 0.480807924469896 0.95990410265086 1 GO:0001972 retinoic acid binding 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0015095 magnesium ion transmembrane transporter activity 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0015464 acetylcholine receptor activity 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0030742 GTP-dependent protein binding 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0042288 MHC class I protein binding 1/2769 20/18639 0.05 0.336565547128927 0.959976658154138 1 GO:0042910 xenobiotic transmembrane transporter activity 2/2769 32/18639 0.0625 0.420706933911159 0.961797879641268 1 GO:0160041 neuropeptide activity 2/2769 32/18639 0.0625 0.420706933911159 0.961797879641268 1 GO:0140597 protein carrier chaperone 20/2769 188/18639 0.106382978723404 0.716096908784952 0.963640055261907 1 GO:0017046 peptide hormone binding 4/2769 53/18639 0.0754716981132075 0.508023467364419 0.965088804744786 1 GO:0034212 protein N-acetyltransferase activity 4/2769 53/18639 0.0754716981132075 0.508023467364419 0.965088804744786 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 4/2769 53/18639 0.0754716981132075 0.508023467364419 0.965088804744786 1 GO:0005248 voltage-gated sodium channel activity 1/2769 21/18639 0.0476190476190476 0.320538616313264 0.965928891548584 1 GO:0015174 basic amino acid transmembrane transporter activity 1/2769 21/18639 0.0476190476190476 0.320538616313264 0.965928891548584 1 GO:0005267 potassium channel activity 12/2769 124/18639 0.0967741935483871 0.651417187991472 0.96637786862848 1 GO:0042923 neuropeptide binding 2/2769 33/18639 0.0606060606060606 0.407958238944154 0.966619068678537 1 GO:0004843 cysteine-type deubiquitinase activity 10/2769 108/18639 0.0925925925925926 0.623269531720236 0.968761332455881 1 GO:0004407 histone deacetylase activity 1/2769 22/18639 0.0454545454545455 0.305968679208116 0.970996186601864 1 GO:0005243 gap junction channel activity 1/2769 22/18639 0.0454545454545455 0.305968679208116 0.970996186601864 1 GO:0008093 cytoskeletal anchor activity 1/2769 22/18639 0.0454545454545455 0.305968679208116 0.970996186601864 1 GO:0033558 protein lysine deacetylase activity 1/2769 22/18639 0.0454545454545455 0.305968679208116 0.970996186601864 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/2769 56/18639 0.0714285714285714 0.480807924469896 0.975026858874654 1 GO:0008236 serine-type peptidase activity 20/2769 194/18639 0.103092783505155 0.693949581709129 0.97523128676465 1 GO:0004180 carboxypeptidase activity 3/2769 46/18639 0.0652173913043478 0.438998539733384 0.975298047580984 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2769 23/18639 0.0434782608695652 0.292665693155589 0.975310069574386 1 GO:0005212 structural constituent of eye lens 1/2769 23/18639 0.0434782608695652 0.292665693155589 0.975310069574386 1 GO:0008171 O-methyltransferase activity 1/2769 23/18639 0.0434782608695652 0.292665693155589 0.975310069574386 1 GO:0016917 GABA receptor activity 1/2769 23/18639 0.0434782608695652 0.292665693155589 0.975310069574386 1 GO:0008234 cysteine-type peptidase activity 19/2769 187/18639 0.101604278074866 0.683929988818141 0.976986600387371 1 GO:0015293 symporter activity 14/2769 146/18639 0.0958904109589041 0.645468172576025 0.977412283492316 1 GO:0061733 protein-lysine-acetyltransferase activity 3/2769 47/18639 0.0638297872340425 0.429658145270971 0.978157333966683 1 GO:0046943 carboxylic acid transmembrane transporter activity 19/2769 188/18639 0.101063829787234 0.680292063345704 0.978487099543489 1 GO:0004806 triacylglycerol lipase activity 1/2769 24/18639 0.0416666666666667 0.280471289274106 0.978982524309481 1 GO:0008514 organic anion transmembrane transporter activity 29/2769 269/18639 0.107806691449814 0.725680361839323 0.979666740402091 1 GO:0005342 organic acid transmembrane transporter activity 19/2769 189/18639 0.100529100529101 0.676692634439113 0.979899156088499 1 GO:0017116 single-stranded DNA helicase activity 4/2769 58/18639 0.0689655172413793 0.464228340867486 0.980102762818661 1 GO:0005244 voltage-gated monoatomic ion channel activity 17/2769 173/18639 0.0982658959537572 0.661458300715811 0.980516246420218 1 GO:0030145 manganese ion binding 5/2769 68/18639 0.0735294117647059 0.494949334013129 0.980521046912286 1 GO:0038187 pattern recognition receptor activity 3/2769 48/18639 0.0625 0.420706933911159 0.980699407161824 1 GO:0015103 inorganic anion transmembrane transporter activity 16/2769 165/18639 0.096969696969697 0.652733182310647 0.98093337531787 1 GO:0017171 serine hydrolase activity 20/2769 198/18639 0.101010101010101 0.679930398240257 0.981001564147839 1 GO:0015645 fatty acid ligase activity 1/2769 25/18639 0.04 0.269252437703142 0.982108894988345 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2769 25/18639 0.04 0.269252437703142 0.982108894988345 1 GO:0019707 protein-cysteine S-acyltransferase activity 1/2769 25/18639 0.04 0.269252437703142 0.982108894988345 1 GO:0120515 fatty acid-CoA ligase activity 1/2769 25/18639 0.04 0.269252437703142 0.982108894988345 1 GO:0030594 neurotransmitter receptor activity 8/2769 97/18639 0.0824742268041237 0.555159665367303 0.982474920382352 1 GO:0004497 monooxygenase activity 9/2769 106/18639 0.0849056603773585 0.571526400784971 0.982499851007839 1 GO:0008080 N-acetyltransferase activity 5/2769 69/18639 0.072463768115942 0.487776155259315 0.98250771421468 1 GO:0098960 postsynaptic neurotransmitter receptor activity 5/2769 69/18639 0.072463768115942 0.487776155259315 0.98250771421468 1 GO:0022832 voltage-gated channel activity 17/2769 175/18639 0.0971428571428571 0.653898777279059 0.983118381869253 1 GO:0042887 amide transmembrane transporter activity 2/2769 38/18639 0.0526315789473684 0.354279523293608 0.983156922763122 1 GO:0005249 voltage-gated potassium channel activity 8/2769 98/18639 0.0816326530612245 0.549494770822739 0.984040248882975 1 GO:0015294 solute:monoatomic cation symporter activity 10/2769 116/18639 0.0862068965517241 0.580285426084358 0.984153791742907 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/2769 26/18639 0.0384615384615385 0.25889657471456 0.984770357853783 1 GO:0015079 potassium ion transmembrane transporter activity 15/2769 160/18639 0.09375 0.631060400866739 0.985200729933667 1 GO:0015276 ligand-gated monoatomic ion channel activity 18/2769 186/18639 0.0967741935483871 0.651417187991472 0.986082249733057 1 GO:0005272 sodium channel activity 3/2769 51/18639 0.0588235294117647 0.395959467210503 0.986737795272703 1 GO:0008395 steroid hydroxylase activity 1/2769 27/18639 0.037037037037037 0.249307812688094 0.987036025887033 1 GO:0016405 CoA-ligase activity 1/2769 27/18639 0.037037037037037 0.249307812688094 0.987036025887033 1 GO:0023026 MHC class II protein complex binding 1/2769 27/18639 0.037037037037037 0.249307812688094 0.987036025887033 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/2769 27/18639 0.037037037037037 0.249307812688094 0.987036025887033 1 GO:0099094 ligand-gated monoatomic cation channel activity 12/2769 136/18639 0.0882352941176471 0.593939200815754 0.987134582765766 1 GO:0071855 neuropeptide receptor binding 2/2769 40/18639 0.05 0.336565547128927 0.987238806479315 1 GO:0008083 growth factor activity 15/2769 162/18639 0.0925925925925926 0.623269531720236 0.987309233534263 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 23/2769 229/18639 0.100436681222707 0.676070531350684 0.987711734914739 1 GO:0022834 ligand-gated channel activity 18/2769 188/18639 0.0957446808510638 0.644487217906457 0.987957784862276 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/2769 73/18639 0.0684931506849315 0.461048694697161 0.988701891341216 1 GO:0022824 transmitter-gated monoatomic ion channel activity 4/2769 63/18639 0.0634920634920635 0.427384821751019 0.988863669247667 1 GO:0022835 transmitter-gated channel activity 4/2769 63/18639 0.0634920634920635 0.427384821751019 0.988863669247667 1 GO:0008227 G protein-coupled amine receptor activity 2/2769 41/18639 0.0487804878048781 0.328356631345295 0.988900488430046 1 GO:0050698 proteoglycan sulfotransferase activity 1/2769 28/18639 0.0357142857142857 0.240403962234948 0.988964740926728 1 GO:0140375 immune receptor activity 14/2769 156/18639 0.0897435897435897 0.604092007667306 0.989640290781922 1 GO:0003678 DNA helicase activity 5/2769 74/18639 0.0675675675675676 0.454818306930983 0.989887947756979 1 GO:0016417 S-acyltransferase activity 1/2769 29/18639 0.0344827586206897 0.232114170433743 0.990606599632541 1 GO:0016887 ATP hydrolysis activity 46/2769 417/18639 0.11031175059952 0.742542693905547 0.991038186746951 1 GO:0008094 ATP-dependent activity, acting on DNA 20/2769 210/18639 0.0952380952380952 0.641077232626528 0.991779989858614 1 GO:0003689 DNA clamp loader activity 14/2769 160/18639 0.0875 0.588989707475623 0.992520943451653 1 GO:0022843 voltage-gated monoatomic cation channel activity 12/2769 143/18639 0.0839160839160839 0.564865253922675 0.992916883642845 1 GO:0005452 solute:inorganic anion antiporter activity 1/2769 31/18639 0.032258064516129 0.217139062663824 0.993194011741502 1 GO:0015370 solute:sodium symporter activity 5/2769 79/18639 0.0632911392405063 0.426032338137883 0.994244444314153 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2769 46/18639 0.0434782608695652 0.292665693155589 0.994511170735773 1 GO:0061749 forked DNA-dependent helicase activity 2/2769 47/18639 0.0425531914893617 0.286438763513981 0.99523800792551 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/2769 47/18639 0.0425531914893617 0.286438763513981 0.99523800792551 1 GO:0022836 gated channel activity 32/2769 318/18639 0.10062893081761 0.677364623152558 0.995570223828069 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/2769 34/18639 0.0294117647058824 0.197979733605251 0.995802766427067 1 GO:0009378 four-way junction helicase activity 2/2769 48/18639 0.0416666666666667 0.280471289274106 0.995870121002192 1 GO:0036121 double-stranded DNA helicase activity 2/2769 48/18639 0.0416666666666667 0.280471289274106 0.995870121002192 1 GO:0043138 3'-5' DNA helicase activity 2/2769 48/18639 0.0416666666666667 0.280471289274106 0.995870121002192 1 GO:0034061 DNA polymerase activity 1/2769 35/18639 0.0285714285714286 0.192323169787958 0.996427444726634 1 GO:0004190 aspartic-type endopeptidase activity 1/2769 36/18639 0.0277777777777778 0.186980859516071 0.996959180135791 1 GO:0016409 palmitoyltransferase activity 1/2769 36/18639 0.0277777777777778 0.186980859516071 0.996959180135791 1 GO:0070001 aspartic-type peptidase activity 1/2769 37/18639 0.027027027027027 0.181927322772393 0.997411796928996 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/2769 268/18639 0.0932835820895522 0.627920796882327 0.99741449118132 1 GO:0140097 catalytic activity, acting on DNA 33/2769 336/18639 0.0982142857142857 0.661110896146107 0.997662043072225 1 GO:0003724 RNA helicase activity 4/2769 77/18639 0.051948051948052 0.349678490523561 0.997971117136375 1 GO:0140658 ATP-dependent chromatin remodeler activity 12/2769 158/18639 0.0759493670886076 0.511238805765459 0.99817809103365 1 GO:0008186 ATP-dependent activity, acting on RNA 4/2769 79/18639 0.0506329113924051 0.340825870510306 0.998421581824569 1 GO:0000510 H3-H4 histone complex chaperone activity 11/2769 151/18639 0.0728476821192053 0.49036039979049 0.998550786376746 1 GO:0140584 chromatin extrusion motor activity 11/2769 151/18639 0.0728476821192053 0.49036039979049 0.998550786376746 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 11/2769 151/18639 0.0728476821192053 0.49036039979049 0.998550786376746 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 11/2769 151/18639 0.0728476821192053 0.49036039979049 0.998550786376746 1 GO:0003777 microtubule motor activity 3/2769 68/18639 0.0441176470588235 0.296969600407877 0.998556666226759 1 GO:0008528 G protein-coupled peptide receptor activity 8/2769 122/18639 0.0655737704918033 0.44139743885761 0.998571586808887 1 GO:0046873 metal ion transmembrane transporter activity 46/2769 450/18639 0.102222222222222 0.688089563019141 0.998618380591463 1 GO:0015616 DNA translocase activity 11/2769 152/18639 0.0723684210526316 0.487134344528711 0.998685380134739 1 GO:0140674 ATP-dependent histone chaperone activity 11/2769 152/18639 0.0723684210526316 0.487134344528711 0.998685380134739 1 GO:0001217 DNA-binding transcription repressor activity 25/2769 278/18639 0.0899280575539568 0.605333717857783 0.998767407680558 1 GO:0061775 cohesin loader activity 11/2769 153/18639 0.0718954248366013 0.483950459923948 0.998807958784737 1 GO:0015081 sodium ion transmembrane transporter activity 12/2769 164/18639 0.0731707317073171 0.492534947017943 0.99896984792595 1 GO:0140713 histone chaperone activity 12/2769 164/18639 0.0731707317073171 0.492534947017943 0.99896984792595 1 GO:0001653 peptide receptor activity 8/2769 128/18639 0.0625 0.420706933911159 0.999251506007304 1 GO:0042605 peptide antigen binding 1/2769 45/18639 0.0222222222222222 0.149584687612857 0.999287290474521 1 GO:0004386 helicase activity 10/2769 155/18639 0.0645161290322581 0.434278125327648 0.999639678647134 1 GO:0005179 hormone activity 6/2769 132/18639 0.0454545454545455 0.305968679208116 0.999963423505893 1 GO:0003823 antigen binding 9/2769 174/18639 0.0517241379310345 0.348171255650615 0.999986473581544 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 40/2769 484/18639 0.0826446280991736 0.556306689469302 0.999996644780742 1 GO:0003730 mRNA 3'-UTR binding 16/2769 262/18639 0.0610687022900763 0.411072423974262 0.999997306016066 1 GO:0001216 DNA-binding transcription activator activity 40/2769 491/18639 0.0814663951120163 0.548375636869943 0.999998106048843 1 GO:0045182 translation regulator activity 10/2769 356/18639 0.0280898876404494 0.189081768049959 0.999999999999996 1 GO:0004984 olfactory receptor activity 1/2769 419/18639 0.00238663484486874 0.0160651812472042 1 1 GO:0030371 translation repressor activity 5/2769 329/18639 0.0151975683890578 0.10229955839785 1 1