category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	60/606	238/9376	3.90049088942508	C3/C1QB/C1QC/C3AR1/IL1B/RPL37/RPS29/CYBB/RPS27/RPL39/RPS21/RPL21/C1QA/RPS25/RPL38/C7/FOS/RPL41/RPS17/CCL2/RPL36A/RPL36/RPL34/RPS11/RPL37A/RPS16/RPS18/RPS15A/RPS13/RPL27A/FCGR2A/TLR2/RPL12/RPLP2/NLRP3/C5AR1/RPL35A/RPS7/RPS5/RPS3A/RPL30/RPL8/RPL22/RPL27/TLR8/RPL5/RPL31/IL6/RPS23/RPS27A/RPS20/RPL9/RPL26/RPL17/EGFR/IFNAR1/C1R/VWF/MAPK10/TLR4	11.9139716116111
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	43/606	155/9376	4.29221760885766	FCGR3A/CD36/HLA-DRA/HLA-DPA1/MSR1/PLA2R1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/CYBB/HLA-DMB/CD209/CYBA/ACTB/HLA-DOA/HLA-DQB1/FCGR1A/CANX/CALR/CTSS/TUBB/CLEC7A/FCGR2A/LAMP1/TLR2/THBS1/ITGAV/RAC1/ATP6V0C/VAMP3/FCGR3B/ATP6V0B/FCAR/LAMP2/M6PR/C1R/CORO1A/TLR4	10.8639441711432
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	23/606	50/9376	7.11709570957096	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DMA/CXCL12/HLA-DMB/TNFSF13/HLA-DOA/HLA-DQB1/CXCR4/CD86/IL10/TNFSF13B/CD40/IL6/CD28/ITGA4/LTBR/IL15	11.3999967057082
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	29/606	82/9376	5.47178620301054	CD74/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/LGMN/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HSPA5/HLA-DMB/HSPA1B/HSPA1A/HLA-DOA/HLA-DQB1/CTSB/HSPA6/CIITA/CANX/CALR/CTSS/PSME1/PDIA3/HSPA1L/IFI30/B2M/TAPBP	10.6907648577352
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	42/606	181/9376	3.59017559214485	FCGR3A/CD74/HLA-DRA/HLA-DPA1/PLA2R1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/HLA-DMB/CD209/IFNGR1/HLA-DOA/HLA-DQB1/FCGR1A/RHOA/CIITA/FCER1G/IFNGR2/CTSS/CLEC7A/FCGR2A/LAMP1/TLR2/RIPK2/TLR1/IRAK2/IL10/BCL10/ATP6V0C/FCGR3B/ATP6V0B/IL6/LAMP2/MAPK10/CORO1A/BID/TLR4	9.24942597177088
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	29/606	95/9376	4.72301545944068	CCL3L1/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/CXCL12/HLA-DMB/TNFRSF11A/TNFSF13/CCL3/FOS/CCL2/HLA-DOA/HLA-DQB1/TLR2/CD86/ATP6V0C/TNFSF13B/CXCL3/ATP6V0B/IL6/CD28/IL15/TLR4	9.58697090805703
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	26/606	78/9376	5.15731573157316	FCGR3A/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/CYBB/HLA-DMB/IFNGR1/FOS/CYBA/HLA-DOA/HLA-DQB1/FCGR1A/IFNGR2/FCGR2A/TLR2/IL10/FCGR3B/ITGA4/TLR4	9.69142619445148
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	38/606	174/9376	3.37893099654793	HSPA5/HSPA1B/DNAJB1/HSPA1A/HERPUD1/SSR1/HSPA6/CANX/CALR/MAP3K5/RPN2/TRAM1/HSP90B1/SEC62/EDEM1/DNAJB11/DDIT3/PDIA3/UBE2J1/HSPA1L/UBE2D3/SELENOS/DAD1/AMFR/KRTCAP2/DNAJC3/BCAP29/SAR1B/ATF6B/PDIA6/MAPK10/XBP1/BCAP31/DERL2/CRYAB/SSR3/STT3B/TMEM258	8.32602112236961
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	27/606	99/9376	4.21962196219622	FCGR3A/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/C1QB/C1QC/HLA-DQA1/C3AR1/HLA-DRB1/HLA-DMA/HLA-DMB/C1QA/HLA-DOA/HLA-DQB1/FCGR1A/FPR1/KRT24/FCGR2A/IL10/C5AR1/KRT10/FCGR3B/FCAR/C1R	8.46527076620802
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	31/606	138/9376	3.47558234084278	IL1B/ACTR3/CDC42/FOS/ACTB/CCL2/RHOA/ACTR2/FYB1/FCGR2A/WASF2/NLRP3/IL10/RAC1/ARF6/ROCK1/SKAP2/IL6/MAP2K1/ARPC4/ARPC1B/RHOG/ARPC1A/LCP2/ITGA4/GNAQ/WAS/GIT2/MAPK10/RPS6KA1/TLR4	7.70105267402635
Human Diseases	Immune disease	hsa05330	Allograft rejection	16/606	39/9376	6.34746551578235	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/CD86/IL10/CD40/CD28	8.79627443238504
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	27/606	112/9376	3.72984441301273	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DMA/HLA-DMB/HSPA1B/IFNGR1/HSPA1A/HLA-DOA/HLA-DQB1/HSPA6/CIITA/IFNGR2/TLR2/LY96/IL10/HSPA1L/CD40/PIK3CG/PIK3R5/LAMA2/MAPK10/TLR4	7.63958534517949
Genetic Information Processing	Translation	hsa03010	Ribosome	40/606	222/9376	2.78773823328279	RPL37/RPS29/RPS27/RPL39/RPS21/RPL21/RPS25/RPL38/RPL41/RPS17/RPL36A/RPL36/RPL34/RPS11/RPL37A/RPS16/RPS18/RPS15A/RPS13/RPL27A/MRPL23/RPL12/RPLP2/RPL35A/RPS7/RPS5/RPS3A/RPL30/RPL8/RPL22/RPL27/RPL5/RPL31/RPS23/RPS27A/RPS20/RPL9/RPL26/RPL17/MRPL18	7.08593419774884
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	20/606	66/9376	4.68846884688469	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/HLA-DMB/MAF/IFNGR1/HLA-DOA/HLA-DQB1/IL21R/IFNGR2/TLR2/IL10/IL6/TLR4	7.90433613658336
Human Diseases	Immune disease	hsa05310	Asthma	14/606	32/9376	6.76897689768977	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/FCER1G/IL10/CD40	8.59269759197318
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/606	45/9376	5.5011367803447	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/CD86/IL6/CD28	7.95584889929601
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	35/606	193/9376	2.80579353272115	CX3CR1/CCL3L1/CCL4L2/CXCL12/CCL4/CDC42/CCL3/CXCL16/CCL2/CXCL14/GNG10/RHOA/GNG11/CXCR4/DOCK2/GNG2/GNB1/RAC1/ROCK1/CXCL3/PAK1/TIAM1/GNB2/MAP2K1/GNB4/HCK/RAP1B/PIK3CG/GNAQ/WAS/PIK3R5/PRKACB/JAK3/ARRB2/LYN	6.66310426562729
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/606	44/9376	5.27452745274527	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/CD86/CD28	7.47049255759136
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/606	70/9376	4.199528524281	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/ACTB/HLA-DOA/HLA-DQB1/CD86/RAC1/CD40/CD28/LAMA2/BID	7.06277930556851
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	30/606	157/9376	2.95642303083812	CX3CR1/CD36/PTGER4/LIPA/C1QB/C1QC/HIF1A/SGK1/C1QA/PECAM1/CH25H/SIGLEC10/LRP1/GAS6/CALR/MERTK/THBS1/ITGAV/IL10/RAC1/SIRPA/MAP2K1/RAB14/PANX1/DUSP8/ADAM9/SCARF1/P2RY12/TMEM30A/PROS1	6.49819648600072
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/606	109/9376	3.40666727223181	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/TGFBR1/HIF1A/HLA-DMA/RUNX1/HLA-DMB/IFNGR1/FOS/HLA-DOA/HLA-DQB1/IL21R/IFNGR2/AHR/IL6/TGFBR2/JAK3/MAPK10	6.64326953367015
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/606	205/9376	2.64155196007406	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/VIM/TNFAIP3/HLA-DOA/HLA-DQB1/CDKN1B/ENTPD1/CALR/TLR2/HES1/GADD45B/CDK6/RAC1/PDIA3/PSMC4/CD40/IL6/BTK/B2M/IFNAR1/JAK3/MAPK10/BID/LYN/TAPBP/PSMD12	6.24662408576558
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	16/606	54/9376	4.58428065028725	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/CD86/IL10/CD40/CD28	6.9433089794297
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/606	98/9376	3.47329426820233	FCGR3A/MARCKS/ACTR3/CDC42/PTPRC/GSN/FCGR1A/ACTR2/FCGR2A/WASF2/RAC1/ARF6/FCGR3B/PAK1/MAP2K1/ARPC4/ARPC1B/CFL1/ARPC1A/HCK/WAS/LYN	6.46969486773919
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	15/606	50/9376	4.64158415841584	CD36/IL1B/PECAM1/CCL2/SDC2/LRP1/HGF/CD81/TLR2/VCAM1/THBS1/IL10/CD40/IL6/TLR4	6.78656169210265
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/606	227/9376	2.4537008766956	CCL3L1/PTGER4/CCL4L2/IL1B/HLA-C/CXCL12/CCL4/CCL3/CCL2/GNG10/RHOA/GNG11/CXCR4/CALR/GNG2/ITGAV/GNA13/CDK6/GNB1/RAC1/PDIA3/ROCK1/PDGFRA/IL6/GNB2/MAP2K1/GNB4/B2M/CREB5/ATF6B/GNAQ/EGFR/PRKACB/BID/CREB3L2/TAPBP	5.82805069430655
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/606	100/9376	3.24910891089109	CD36/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/HLA-DMB/HLA-DOA/HLA-DQB1/FCGR1A/CD59/CSF3R/CSF2RA/CD33/IL6/CD37/ITGA4	5.94363689409085
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/606	180/9376	2.57865786578658	CD74/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/IFNGR1/CCL2/HLA-DOA/HLA-DQB1/CALR/IFNGR2/TLR2/PILRA/PDIA3/PPP1CB/PILRB/IL6/POU2F2/B2M/IFNAR1/BID/TAPBP	5.62143175587073
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	37/606	250/9376	2.28984818481848	LIPA/LGMN/LAPTM5/CD164/CD68/LAPTM4A/CTSB/CTSA/SLC11A2/NAGA/CTSH/CTSS/NPC2/LAMP1/PSAP/AP1S2/CD63/CTSW/ATP6V0C/TLR8/ATP6V0B/MAN2B1/FUCA2/VPS29/LAMP2/ASAH1/GALC/NEU1/PPT1/M6PR/GAA/GLB1/SLC15A3/IDS/CLN5/DNASE2/BLOC1S6	5.43363576148788
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/606	103/9376	3.15447467076805	CCL3L1/C3/C1QB/C1QC/IL1B/TGFBR1/C1QA/IFNGR1/CCL3/FOS/CCL2/CALR/IFNGR2/TLR2/IL10/IL6/TGFBR2/PPP2CA/GNAQ/MAPK10/TLR4	5.77925727942664
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/606	224/9376	2.34842055634135	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/TGFBR1/HLA-DMA/HLA-DMB/FOS/ZFP36/HLA-DOA/HLA-DQB1/CANX/CALR/CD40/IL6/MAP2K1/TGFBR2/ETS2/VDAC2/B2M/CREB5/ELK4/ATF6B/PRKACB/JAK3/MAPK10/LTBR/CREB3L2/IL15/PTEN	5.36924871232261
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	19/606	88/9376	3.34053405340534	C3/C1QB/C1QC/C3AR1/VSIG4/C1QA/C7/SERPINA1/CD59/PLAU/A2M/C5AR1/PLAUR/VTN/CD46/C1R/VWF/F3/PROS1	5.79852255149491
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/606	216/9376	2.36376971030436	CD36/CCL3L1/IL1B/HSPA5/CYBB/HSPA1B/CDC42/CCL3/FOS/CYBA/HSPA1A/CCL2/RHOA/HSPA6/MAP3K5/TLR2/HSP90B1/VCAM1/LY96/NLRP3/DDIT3/RAC1/HSPA1L/CXCL3/CD40/IL6/POU2F2/RAP1B/MAPK10/XBP1/BID/LYN/TLR4	5.3301856134493
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/606	142/9376	2.72393436526751	FCGR3A/IL1B/TGFBR1/LILRB1/IFNGR1/TNFRSF11A/FOS/CYBA/LILRB2/FCGR1A/LILRB5/IFNGR2/FCGR2A/TYROBP/RAC1/SIRPA/FCGR3B/MAP2K1/TGFBR2/BTK/LCP2/IFNAR1/MAPK10/LILRA1/JUNB	5.44116778050358
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	25/606	143/9376	2.7048858732027	FCGR3A/HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/C3/HLA-DRB5/C1QB/C1QC/HLA-DQA1/HLA-DRB1/HLA-DMA/HLA-DMB/C1QA/C7/HLA-DOA/HLA-DQB1/FCGR1A/FCGR2A/CD86/IL10/FCGR3B/CD40/CD28/C1R	5.40025250127072
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	28/606	173/9376	2.50413018180431	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/IL1B/HLA-DRB1/HLA-DMA/HLA-DMB/DNAJB1/IFNGR1/ACTB/CCL2/HLA-DOA/HLA-DQB1/CIITA/IFNGR2/HNRNPUL1/NLRP3/CDK6/PABPN1/IL6/MAP2K1/DNAJC3/IFNAR1/BID/TLR4	5.24887124971199
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/606	109/9376	2.83888939352651	CCL3L1/CCL4L2/IL1B/CCL4/CCL3/FOS/MAP3K8/TLR2/CD86/LY96/TLR1/RAC1/TLR8/CD40/IL6/MAP2K1/IRF5/IFNAR1/MAPK10/TLR4	5.07599784347221
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	16/606	78/9376	3.17373275789117	C3/C1QB/C1QC/IL1B/C1QA/FOS/IRF8/RHOA/LY96/NLRP3/IL10/IL6/CFL1/C1R/MAPK10/TLR4	5.06734921035022
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	19/606	105/9376	2.799685682854	CCL4L2/IL1B/CXCL12/CCL4/TNFRSF11A/TNFAIP3/CSNK2B/PLAU/VCAM1/LY96/GADD45B/BCL10/TNFSF13B/CXCL3/CD40/BTK/LTBR/LYN/TLR4	4.87472560184007
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	36/606	275/9376	2.02541854185419	C1QB/C1QC/IL1B/HSPA5/CYBB/HSPA1B/C1QA/C7/CYBA/HSPA1A/HSPA6/TUBB/NDUFA2/MT-ND3/NDUFB1/CSNK2B/DDIT3/RAC1/HSPA1L/NDUFA4/PSMC4/IL6/NDUFA3/VDAC2/CREB5/ATF6B/PRKACB/NDUFA1/MAPK10/ATP5PB/NDUFB9/CREB3L2/PSMA4/COX6B1/PSMD12/SDHC	4.53675273295566
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	29/606	204/9376	2.19944347375914	LUM/DCN/HIF1A/CDC42/ACTB/FZD1/SDC2/RHOA/COL1A1/HGF/FZD2/PLAU/TLR2/THBS1/ITGAV/GPC3/CD63/RAC1/ROCK1/PPP1CB/PAK1/PLAUR/TIAM1/MAP2K1/CBL/VTN/EGFR/PRKACB/TLR4	4.55286738079321
Organismal Systems	Immune system	hsa04611	Platelet activation	21/606	126/9376	2.57865786578658	COL3A1/ACTB/RHOA/COL1A1/FCER1G/FCGR2A/GNA13/ROCK1/PPP1CB/BTK/TBXAS1/LCP2/RAP1B/PIK3CG/GNAQ/PIK3R5/MYL12A/PRKACB/VWF/LYN/P2RY12	4.6894788083978
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/606	196/9376	2.21027817067421	C3/HLA-C/HIF1A/CLEC2B/IFNGR1/FOS/ZFP36/GNG10/GNG11/GNG2/CD86/CDK6/GNB1/RAC1/CXCL3/IL6/RPS27A/GNB2/MAP2K1/GNB4/HCK/PIK3CG/IFNAR1/PIK3R5/MAPK10/BID/LYN/MAP1LC3B	4.50105219198343
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/606	93/9376	2.82820540118528	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DMA/HLA-DMB/MAF/IFNGR1/FOS/HLA-DOA/HLA-DQB1/IFNGR2/JAK3/MAPK10	4.65740966754771
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/606	160/9376	2.32079207920792	HLA-DRA/HLA-DPA1/HLA-DQA2/HLA-DPB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-C/HLA-DMA/HLA-DMB/VCAN/PECAM1/PTPRC/HLA-DOA/HLA-DQB1/SDC2/VCAM1/CD86/ITGAV/VSIR/CD40/CADM3/CD28/ITGA4	4.4294047565429
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	32/606	248/9376	1.99638028318961	IL1B/ACTR3/CDC42/FOS/PTPRC/ACTB/RHOA/ACTR2/SNX9/TUBB/RHOB/TLR2/HSP90B1/RIPK2/LY96/NLRP3/PFN1/RAC1/ARF6/PAK1/IL6/MAP2K1/ARPC4/ARPC1B/RHOG/ARPC1A/M6PR/PIK3CG/MYL12A/MAPK10/ABI1/TLR4	4.18008683082321
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	42/606	362/9376	1.79508779607242	SGK1/COL6A1/CDKN1B/COL6A2/GNG10/GNG11/COL1A1/LPAR6/LPAR5/YWHAH/CSF3R/HGF/COL6A3/TLR2/HSP90B1/GNG2/THBS1/ITGAV/CDK6/GNB1/RAC1/PDGFRA/IL6/GNB2/MAP2K1/GNB4/PRL/CREB5/PPP2CA/ATF6B/PIK3CG/VTN/ITGA4/EGFR/IFNAR1/PIK3R5/LAMA2/JAK3/VWF/CREB3L2/TLR4/PTEN	4.05539115352806
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/606	56/9376	3.31541725601132	C3/IL1B/HSPA1B/HSPA1A/EEF1G/HSPA6/TLR2/HSPA1L/CXCL3/IL6/SAR1B/TLR4	4.56811971249269
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/606	232/9376	2.00068282690338	TMSB4X/CXCL12/ACTR3/CDC42/C7/ACTB/GSN/RHOA/CXCR4/LPAR5/ACTR2/WASF2/ITGAV/GNA13/PFN1/RAC1/ROCK1/PPP1CB/PAK1/PDGFRA/SPATA13/TIAM1/MAP2K1/ARPC4/ARPC1B/CFL1/ARPC1A/ITGA4/EGFR/MYL12A	4.05690169409912
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/606	203/9376	2.05784519338633	CDC42/ACTB/COL6A1/COL6A2/RHOA/COL1A1/ARHGAP5/HGF/COL6A3/THBS1/ITGAV/RAC1/ROCK1/PPP1CB/PAK1/PDGFRA/MAP2K1/RAP1B/VTN/ITGA4/EGFR/MYL12A/PARVG/LAMA2/VWF/MAPK10/PTEN	4.00531422338408
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/606	93/9376	2.66184037758615	TGFBR1/CDC42/ACTB/PTPRJ/RHOA/CSNK2B/WASF2/CTNND1/RAC1/ROCK1/TGFBR2/RAP1B/EGFR/WAS/MYL12A/PDCD10	4.23358963684981
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	31/606	250/9376	1.91852145214521	HLA-C/TGFBR1/HSPA1B/ACTR3/CDC42/HSPA1A/CHMP1B/RHOA/CXCR4/HSPA6/ACTR2/ARF5/CAPZA2/CHMP4B/ARF6/HSPA1L/PDGFRA/TGFBR2/RAB31/CAPZA1/ARPC4/ARPC1B/VPS29/ARPC1A/CBL/SNX6/EGFR/GIT2/PDCD6IP/ARRB2/ARAP1	3.86937863603877
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/606	136/9376	2.27528635216463	IL1B/HSPA1B/CD209/FOS/HSPA1A/TNFAIP3/CDKN1B/HSPA6/CSNK2B/TLR2/CDK6/HSPA1L/IL6/CD28/CD46/IFNAR1/JAK3/MAPK10/BID/TLR4	3.9378877663585
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/606	200/9376	2.01135313531353	IL1B/ACTR3/CDC42/TMBIM6/FOS/ACTB/RHOA/LPAR5/ACTR2/TUBB/FCGR2A/WASF2/GNA13/NLRP3/RAC1/ARF6/ROCK1/PAK1/TMED10/IL6/ARPC4/ARPC1B/ARPC1A/MAPK10/ABI1/TLR4	3.80025968205186
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/606	31/9376	3.99276056637922	HSPA5/SEC11A/SPCS3/SEC62/SRP9/SPCS2/SPCS1/SRP19	4.38717865845027
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/606	130/9376	2.26128458999746	TGFBR1/COL3A1/FOS/GNG10/GNG11/COL1A1/GNG2/GNB1/GNB2/MAP2K1/TGFBR2/GNB4/CREB5/ATF6B/EGFR/PRKACB/MAPK10/ARRB2/CREB3L2	3.80653629302447
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/606	18/9376	5.15731573157316	NEU4/ENGASE/MAN2B1/FUCA2/NEU1/GLB1	4.6406615345539
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/606	142/9376	2.17914749221401	IL1B/DUSP1/PECAM1/FOS/CYBA/ACTB/CCL2/SDC2/RHOA/KLF2/MEF2C/MAP3K5/HSP90B1/VCAM1/ITGAV/GSTT2B/RAC1/GSTM4/MGST1/MAPK10	3.72168423134884
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/606	166/9376	2.0504990258062	RHOA/KCNMB4/ADRB2/RGS2/KCNMA1/MEF2C/GNA13/ATP1B1/ROCK1/PPP1CB/ATP1B3/MAP2K1/MEF2D/VDAC2/CREB5/ADRB1/ATF6B/PIK3CG/GNAQ/PIK3R5/CREB3L2/SLC8A1	3.58956677332747
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/606	42/9376	3.31541725601132	CYBB/FTH1/PCBP1/SLC11A2/SLC40A1/SAT1/VDAC2/NCOA4/MAP1LC3B	3.95313973634598
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	33/606	298/9376	1.71333643431457	CX3CR1/CCL3L1/CCL4L2/IL1B/TGFBR1/CXCL12/CCL4/IFNGR1/TNFRSF11A/TNFSF13/CCL3/CXCL16/CCL2/CXCL14/CXCR4/IL13RA1/CSF3R/IL21R/IFNGR2/CSF2RA/IL10/RELL1/TNFSF13B/CXCL3/CD40/BMP5/IL6/TGFBR2/IL17RA/PRL/IFNAR1/LTBR/IL15	3.28949782069905
NA	NA	hsa04517	IgSF CAM signaling	33/606	299/9376	1.70760621212623	MTSS1/CD209/ACTR3/CDC42/ACTB/RHOA/CSK/ACTR2/TUBB/EPB41L2/EPB41L3/CD86/CD84/RAC1/NPHS1/ARF6/PAK1/CADM3/MAP2K1/ARPC4/ARPC1B/CRTAM/CD28/ARPC1A/LCP2/RAP1B/ITGA4/KCNQ3/MYL12A/MAPK10/SLIT2/CD48/LYN	3.26872373826946
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/606	101/9376	2.29781393980982	IL1B/TGFBR1/CYBB/COL3A1/CDC42/CCL2/CDKN1B/COL1A1/VCAM1/RAC1/PIM1/IL6/TGFBR2/MAPK10/F3	3.44697644732949
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/606	55/9376	2.81308130813081	DEGS1/NEU4/PSAP/SGPP1/ACER3/ASAH1/GALC/NEU1/GLB1/SGPL1	3.54478194463264
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/606	125/9376	2.10418481848185	DEGS1/RHOA/FCER1G/MAP3K5/GNA13/RAC1/SGPP1/ROCK1/MAP2K1/ASAH1/PPP2CA/GNAQ/ORMDL1/MAPK10/SGPL1/BID/PTEN	3.26681537824647
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/606	214/9376	1.80747046667284	HLA-C/FOS/GNG10/GNG11/CXCR4/CALR/TLR2/GNG2/AP1S2/GNB1/RAC1/PDIA3/SAMHD1/PAK1/GNB2/MAP2K1/GNB4/CFL1/B2M/GNAQ/MAPK10/BID/RNF7/TLR4/TAPBP	3.14094653173974
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/606	115/9376	2.15261874013488	SGK1/FOS/PDE4B/RHOA/MEF2C/GNA13/MAP2K1/MEF2D/NR4A2/CREB5/ATF6B/GNAQ/EGFR/PRKACB/ARRB2/CREB3L2	3.26909700745658
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/606	227/9376	1.77211729983571	HIF1A/FOS/CYBA/PTPRJ/HGF/NDUFA2/MT-ND3/NDUFB1/MAP3K5/AHR/GSTT2B/RAC1/NDUFA4/MAP2K1/NDUFA3/VDAC2/GSTM4/MGST1/EGFR/NDUFA1/MAPK10/ATP5PB/NDUFB9/COX6B1/PTEN/SDHC	3.09550529791411
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/606	116/9376	2.13406168203027	CXCL12/CYBB/CDC42/PECAM1/CYBA/ACTB/RHOA/CXCR4/ARHGAP5/VCAM1/CTNND1/RAC1/ROCK1/RAP1B/ITGA4/MYL12A	3.23059362331055
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/606	140/9376	1.98925035360679	TGFBR1/GNG10/GNG11/KLF2/MEF2C/GNG2/GNA13/GNB1/GNB2/MAP2K1/GNB4/MEF2D/PIK3CG/GNAQ/PIK3R5/PRKACB/MAP1LC3B/SLC8A1	3.09991955319156
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/606	119/9376	2.08026180769337	IL1B/FOS/CCL2/TNFAIP3/MAP3K8/MAP3K5/VCAM1/CXCL3/IL6/MAP2K1/CREB5/ATF6B/MAPK10/CREB3L2/IL15/JUNB	3.11737841834434
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/606	78/9376	2.38029956841838	ACTR3/CDC42/ACTB/RHOA/ACTR2/WASF2/RAC1/ARPC4/ARPC1B/RHOG/ARPC1A/CBL	3.21771841670971
NA	NA	hsa04518	Integrin signaling	19/606	154/9376	1.90887660194591	C3/CDC42/ACTB/COL6A1/COL6A2/COL1A1/HGF/COL6A3/VCAM1/THBS1/ITGAV/RAC1/PDGFRA/VTN/ITGA4/EGFR/PARVG/LAMA2/VWF	2.98933700435119
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/606	300/9376	1.59876787678768	IL1B/TGFBR1/DUSP6/HSPA1B/DUSP1/CDC42/FOS/HSPA1A/HSPA6/MAP3K8/MEF2C/HGF/MAP3K5/GADD45B/DDIT3/RAC1/PPM1B/HSPA1L/PAK1/PDGFRA/DUSP3/MAP2K1/TGFBR2/DUSP8/ELK4/RAP1B/EGFR/PRKACB/MAPK10/ARRB2/RPS6KA1	2.77072887206068
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/606	170/9376	1.8202290817317	RUNX1/ACTR3/CDC42/ACTB/RHOA/ACTR2/MAP3K5/RAC1/ROCK1/TIAM1/ARPC4/ARPC1B/YBX3/ARPC1A/PPP2CA/WAS/MYL12A/PRKACB/MAPK10/AMOT	2.83691479625804
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	23/606	205/9376	1.73587700233438	CD36/TGFBR1/CYBB/COL3A1/CYBA/COL1A1/PDK4/NDUFA2/MT-ND3/NDUFB1/RAC1/NDUFA4/PPP1CB/TGFBR2/NDUFA3/VDAC2/NDUFA1/MAPK10/ATP5PB/NDUFB9/COX6B1/PTEN/SDHC	2.80024459703093
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/606	115/9376	2.01808006887645	FOS/GNG10/GNG11/GNG2/GNB1/GNB2/MAP2K1/GNB4/CREB5/PIK3CG/GNAQ/KCNQ3/PIK3R5/PRKACB/CREB3L2	2.88751378979464
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/606	75/9376	2.26921892189219	HSPA5/CANX/HSP90B1/GPX1/ATP1B1/ATP1B3/CREB5/ATF6B/GNAQ/PRKACB/CREB3L2	2.9008448482637
NA	NA	hsa03272	Virion - Hepatitis viruses	8/606	48/9376	2.57865786578658	CHMP1B/CD81/LAMP1/CD63/CHMP4B/LAMP2/EGFR/PDCD6IP	2.88228234425769
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	16/606	133/9376	1.86128688056776	FCGR3A/HLA-C/IFNGR1/HCST/FCER1G/IFNGR2/TYROBP/RAC1/FCGR3B/PAK1/MAP2K1/LCP2/IFNAR1/BID/CD48/LAT2	2.62959781072739
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	16/606	133/9376	1.86128688056776	FOS/GNG10/GNG11/GNG2/GNB1/PPP1CB/GNB2/GNB4/CREB5/PPP2CA/ATF6B/GNAQ/PRKACB/MAPK10/ARRB2/CREB3L2	2.62959781072739
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	13/606	100/9376	2.01135313531353	CX3CR1/CCL3L1/CCL4L2/CXCL12/CCL4/CCL3/CCL2/CXCL14/CXCR4/IL10/CXCL3/IL6/LTBR	2.67266550716851
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	18/606	157/9376	1.77385381850287	IL1B/CDC42/FOS/NDUFA2/NDUFB1/MAP3K5/DDIT3/RAC1/NDUFA4/IL6/NDUFA3/NDUFA1/MAPK10/NDUFB9/XBP1/BID/COX6B1/SDHC	2.57033069270267
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/606	253/9376	1.59000247850872	C3/IL1B/ACTR3/CDC42/ACTB/RHOA/ACTR2/RIPK2/WASF2/NLRP3/BCL10/PFN1/RAC1/ARF6/ROCK1/UBE2D3/RPS27A/ARPC4/ARPC1B/ARPC1A/EGFR/SEPTIN7/MYL12A/MAPK10/TLR4/MAP1LC3B	2.50073350473169
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/606	59/9376	2.36012753817755	ENTPD1/NME3/DCK/NME2/ENPP1/TK2/UCKL1/DUT/DPYD	2.75479791388135
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/606	91/9376	2.04025677293004	LILRB1/FOS/LILRB2/LILRB5/CD81/CD72/BCL10/RAC1/MAP2K1/BTK/LILRA1/LYN	2.62115345754724
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	27/606	268/9376	1.55874094872174	HSPA5/DUSP1/SNCA/SLC11A2/TUBB/NDUFA2/MT-ND3/NDUFB1/MAP3K5/DDIT3/UBE2J1/NDUFA4/PSMC4/RPS27A/NDUFA3/VDAC2/SLC39A1/PRKACB/NDUFA1/MAPK10/ATP5PB/NDUFB9/XBP1/PSMA4/COX6B1/PSMD12/SDHC	2.43943101147497
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/606	71/9376	2.17914749221401	CDC42/CSK/RAC1/ATP6V0C/CXCL3/ATP6V0B/PAK1/EGFR/MAPK10/LYN	2.621568867374
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/606	61/9376	2.28274630741763	FTH1/SLC11A2/SLC31A1/SLC40A1/ATP1B1/ATP1B3/MT2A/SLC8A1/CYBRD1	2.64202190869072
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/606	139/9376	1.7809435619821	HSPA1B/FOS/HSPA1A/HSPA6/KRT24/HSP90B1/FKBP4/HSPA1L/KRT10/MAP2K1/CREB5/ATF6B/GNAQ/EGFR/PRKACB/CREB3L2	2.43828086753572
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/606	187/9376	1.65475371066518	IL1B/CYBB/CYBA/CCL2/TNFAIP3/RHOA/CTSB/GABARAP/RIPK2/GPSM3/NAMPT/NLRP3/CXCL3/IL6/PANX1/VDAC2/IFNAR1/MAPK10/TLR4/MAP1LC3B	2.37731537693966
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/606	44/9376	2.46144614461446	MGAT4A/RPN2/DAD1/KRTCAP2/ALG2/STT3B/TMEM258	2.5541355547152
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/606	144/9376	1.71910524385772	C3/C1QB/C1QC/C3AR1/IL1B/C1QA/MAP3K5/LY96/C5AR1/CXCL3/ALDH9A1/IL6/IL17RA/TRA2B/MAPK10/TLR4	2.2858512071893
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/606	56/9376	2.21027817067421	MGAT4A/RPN2/DAD1/KRTCAP2/ALG2/ST6GAL1/STT3B/TMEM258	2.38777505639763
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	20/606	195/9376	1.58686637894559	FCGR3A/C3/CYBB/CYBA/ACTB/FCGR1A/FPR1/CLEC7A/FCGR2A/HMGB1/TLR2/C5AR1/RAC1/HDAC9/FCGR3B/TLR8/MAP2K1/VDAC2/VWF/TLR4	2.17687602085156
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/606	89/9376	1.912263136426	CD36/COL6A1/COL6A2/COL1A1/COL6A3/THBS1/ITGAV/VTN/ITGA4/LAMA2/VWF	2.2730006503912
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/606	90/9376	1.89101576824349	HIF1A/IFNGR1/FOS/IFNGR2/CSNK2B/TLR2/MAP2K1/CD28/EGFR/TLR4/PTEN	2.23261818822372
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/606	149/9376	1.66141714842625	GNG10/GNG11/NDUFA2/MT-ND3/NDUFB1/GNG2/GNB1/NDUFA4/GNB2/GNB4/NDUFA3/GNAQ/PRKACB/NDUFA1/MAPK10/NDUFB9	2.13924476597633
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/606	238/9376	1.49518817427961	CDC42/GNG10/RHOA/GNG11/HGF/GNG2/GNB1/RAC1/ARF6/PAK1/PDGFRA/TIAM1/GNB2/MAP2K1/GNB4/ETS2/RAP1B/SHOC2/EGFR/PRKACB/MAPK10/RGL2/RASA3	2.03402047297665
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/606	201/9376	1.53949723330542	RUNX1/DUSP6/MAF/CDKN1B/FCGR1A/BMP2K/MEF2C/ETV5/LMO2/PLAU/BCL6/CD86/GADD45B/DDIT3/CD40/BMI1/IL6/TGFBR2/ELK4/CDK9	2.03238680986354
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/606	333/9376	1.39386911664139	PTGER4/HLA-C/CDC42/COL6A1/FZD1/CDKN1B/COL6A2/COL1A1/FZD2/COL6A3/THBS1/HES1/ITGAV/CDK6/ATP6V0C/ATP6V0B/MAP2K1/CREB5/PPP2CA/VTN/ITGA4/EGFR/IFNAR1/PRKACB/LAMA2/VWF/CREB3L2/BCAP31/MFNG/PTEN	1.92371146783199
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	34/606	388/9376	1.35578918716614	IL1B/CYBB/DKK1/FZD1/SNCA/SLC11A2/LRP1/TUBB/NDUFA2/FZD2/MT-ND3/NDUFB1/MAP3K5/CSNK2B/APH1A/DDIT3/NDUFA4/PSMC4/IL6/MAP2K1/NDUFA3/VDAC2/GNAQ/SLC39A1/NDUFA1/MAPK10/ATP5PB/NDUFB9/XBP1/BID/PSMA4/COX6B1/PSMD12/SDHC	1.88147836939253
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/606	21/9376	2.94703756089895	VNN2/ENPP1/PPCS/DPYD	2.3479250793225
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/606	168/9376	1.56561370422757	IFNGR1/IL13RA1/CSF3R/IL21R/IFNGR2/CSF2RA/IL10/PTPN2/SOCS6/PDGFRA/PIM1/IL6/PRL/EGFR/IFNAR1/JAK3/IL15	1.94452737973316
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/606	169/9376	1.55634971781202	HIF1A/CTSB/VMP1/GABARAP/WDR45B/HMGB1/LAMP1/RPS27A/MAP2K1/LAMP2/ATG4B/PPP2CA/PRKACB/MAPK10/PTEN/ATG4C/MAP1LC3B	1.91846688178053
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/606	120/9376	1.67612761276128	CDC42/SH2B3/RHOA/IRAK3/MAP3K5/RIPK2/IRAK2/RAC1/ARHGDIB/MAP2K1/RAP1B/MAPK10/RPS6KA1	1.95943010507129
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/606	233/9376	1.46087055057437	DCN/COL3A1/VIM/VCAN/ACTB/COL6A1/SDC2/COL6A2/COL1A1/COL6A3/FMNL3/THBS1/ITGAV/CAPZA2/ATP1B1/ATP1B3/CAPZA1/ELN/FBLN2/FBN2/ITGA4/LAMA2	1.87255555843768
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/606	133/9376	1.62862602049679	TGFBR1/SGK1/CDKN1B/KLF2/GABARAP/BCL6/GADD45B/IL10/IL6/MAP2K1/TGFBR2/EGFR/MAPK10/PTEN	1.91926017284154
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/606	52/9376	2.08276212236608	CD36/LIPA/LRP1/VAPA/NPC2/SOAT1/VDAC2	2.05804917552357
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/606	86/9376	1.79906362729296	KCNMB4/KCNMA1/ATP1B1/ATP1B3/CREB5/VAMP2/ATF6B/GNAQ/PRKACB/CREB3L2	1.95679299332757
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/606	122/9376	1.64865011091273	CDC42/FOS/PTPRC/RHOA/MAP3K8/IL10/BCL10/PAK1/MAP2K1/CD28/PPP2CA/LCP2/MAPK10	1.89560487988288
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/606	110/9376	1.68784878487849	DCN/TGFBR1/RHOA/NRROS/THBS1/ROCK1/TGIF1/BMP5/FMOD/TGFBR2/SKIL/PPP2CA	1.90750340846797
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/606	77/9376	1.80840941236981	TGFBR1/CDC42/GADD45B/CDK6/RAC1/MAP2K1/TGFBR2/EGFR/MAPK10	1.87232291993957
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/606	44/9376	2.10981098109811	ARHGDIB/NSF/CREB5/VAMP2/PRKACB/CREB3L2	1.93959092935568
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/606	103/9376	1.65234387516422	IL1B/COL3A1/COL1A1/TLR2/IL10/CXCL3/IL6/GNAQ/PRKACB/LAMA2/TLR4	1.74987580053015
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/606	154/9376	1.50700784364151	ADRB2/ATP1B1/PPP1CB/CREM/ATP1B3/CREB5/ADRB1/PPP2CA/ATF6B/PIK3CG/GNAQ/PIK3R5/PRKACB/CREB3L2/SLC8A1	1.66757214923227
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/606	69/9376	1.7938489501124	FCER1G/RAC1/ALOX5AP/MAP2K1/BTK/LCP2/MAPK10/LYN	1.73972144440912
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/606	105/9376	1.62087065849442	IL1B/CD209/RHOA/FCER1G/CLEC7A/NLRP3/IL10/BCL10/PAK1/IL6/MAPK10	1.68172371610715
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/606	168/9376	1.47351878044947	IL1B/CYBB/IFNGR1/FTH1/TNFAIP3/CHMP1B/IFNGR2/HMGB1/NLRP3/CHMP4B/VDAC2/IFNAR1/JAK3/MAPK10/BID/TLR4	1.62791358575605
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/606	94/9376	1.64595182922548	IL1B/S100A8/FOS/CCL2/TNFAIP3/HSP90B1/CXCL3/IL6/IL17RA/MAPK10	1.65449489237362
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/606	82/9376	1.69814054576189	NME3/GSTT2B/NME2/GSTM4/MGST1/TK2/UCKL1/DUT/DPYD	1.66905484152319
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/606	37/9376	2.09080367496209	IL1B/VCAM1/IL10/IL6/GNAQ	1.74750899693613
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/606	17/9376	2.73034362259755	CH25H/AMACR/SCP2	1.87699989053541
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/606	17/9376	2.73034362259755	CD209/LAMP1/LAMP2	1.87699989053541
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/606	97/9376	1.5950461025484	FOS/GNG10/GNG11/GNG2/PER1/GNB1/GNB2/GNB4/GNAQ/PRKACB	1.54848872812437
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/606	38/9376	2.03578252562098	PTPRC/CIITA/CD40/BTK/JAK3	1.6817273880013
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	9/606	85/9376	1.63820617355853	ENTPD1/NME3/DCK/LACC1/NME2/ENPP1/TK2/UCKL1/DUT	1.55367932782711
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/606	99/9376	1.56282294896156	HIF1A/FOS/WASF2/RAC1/PDGFRA/MAP2K1/SLC44A4/EGFR/WAS/MAPK10	1.47981617479877
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/606	87/9376	1.6005462615227	TGFBR1/FOS/RHOA/GADD45B/RAC1/MAP2K1/TGFBR2/EGFR/MAPK10	1.47925745357424
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/606	205/9376	1.35851243660951	C3/HLA-C/CDC42/GSN/CDKN1B/RHOA/YWHAH/CDK6/RAC1/HNRNPK/HDAC9/CREB5/ATF6B/PRKACB/JAK3/LTBR/LYN/CREB3L2	1.36425314339149
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/606	89/9376	1.56457892980309	GNG10/GNG11/GABARAP/GNG2/GNB1/NSF/GNB2/GNB4/PRKACB	1.40670846316028
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/606	77/9376	1.60747503321761	TGFBR1/RUNX1/CDKN1B/GADD45B/CDK6/MAP2K1/TGFBR2/CBL	1.40694728510172
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	10/606	103/9376	1.50213079560383	COL3A1/COL15A1/COL6A1/COL6A2/COL1A1/COL6A3/ATP1B1/ATP1B3/ELN/SLC8A1	1.3469376526405
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/606	91/9376	1.53019257969753	GNG10/PDE4B/GNG11/GNG2/GNB1/GNB2/GNB4/PRKACB/ARRB2	1.33593565512265
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/606	212/9376	1.31365589389128	CDC42/ACTB/RHOA/FPR1/LPAR5/HGF/FYB1/CTNND1/THBS1/PFN1/RAC1/PDGFRA/TIAM1/MAP2K1/LCP2/RAP1B/GNAQ/EGFR	1.21423010560029
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/606	93/9376	1.49728521239221	CST3/ADRB2/KCNMA1/ATP1B1/ATP1B3/ADRB1/VAMP2/GNAQ/PRKACB	1.26684942196452
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/606	106/9376	1.4596176598792	CDKN1B/ETV5/PLAU/HSP90B1/PDGFRA/MAP2K1/CREB5/EGFR/CREB3L2/PTEN	1.25092688465289
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/606	32/9376	1.93399339933993	AKR1B1/GAA/PGM2/GLB1	1.39115184126339
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/606	32/9376	1.93399339933993	GABARAP/ATG4B/PPP2CA/ATG4C	1.39115184126339
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/606	69/9376	1.56961783134835	PTGER4/CTSB/ADRB2/KCNMA1/ADRB1/GNAQ/PRKACB	1.24831853235333
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/606	33/9376	1.87538753875388	STX11/BET1L/VAMP3/VAMP2	1.32414733013917
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/606	70/9376	1.54719471947195	HIF1A/CDC42/HGF/RAC1/PAK1/MAP2K1/RAP1B	1.20790157408311
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/606	217/9376	1.28338732490761	FOS/ADRB2/PAQR8/AHR/BCL6/HSP90B1/GSTT2B/MAP2K1/CREB5/ADRB1/GSTM4/ATF6B/MGST1/EGFR/PRKACB/ARRB2/CREB3L2/RPS6KA1	1.11021837922808
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/606	83/9376	1.49127201876814	CCL4L2/IL1B/CCL4/PCBP1/NLRP3/SAMHD1/IL6/DNASE2	1.18169462486589
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/606	163/9376	1.32887890015995	TGFBR1/FOS/TLR2/IL6/MAP2K1/TGFBR2/CREB5/ATF6B/IFNAR1/JAK3/MAPK10/BID/CREB3L2/TLR4	1.1134005503045
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/606	110/9376	1.40654065406541	HIF1A/CYBB/IFNGR1/CDKN1B/IFNGR2/IL6/MAP2K1/EGFR/LTBR/TLR4	1.12739558513221
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/606	34/9376	1.8202290817317	BHLHE41/NR1D2/NR1D1/PER1	1.25943814868672
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/606	137/9376	1.35520705355207	FOS/ACTB/CTSB/CTSH/CTSS/MAP3K5/GADD45B/DDIT3/CTSW/MAP2K1/MAPK10/BID	1.10090928576428
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/606	12/9376	2.57865786578658	CD209/CD46	1.43836826297538
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/606	138/9376	1.3453867125843	NDUFA2/MT-ND3/NDUFB1/ATP6V0C/NDUFA4/ATP6V0B/NDUFA3/NDUFA1/ATP5PB/NDUFB9/COX6B1/SDHC	1.07443053807493
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/606	73/9376	1.48361137483611	HGF/GADD45B/CDK6/PDGFRA/MAP2K1/EGFR/PTEN	1.0903566593248
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	36/606	480/9376	1.16039603960396	IL1B/HSPA5/CYBB/DKK1/FZD1/SNCA/TUBB/NDUFA2/FZD2/MT-ND3/NDUFB1/MAP3K5/CSNK2B/GPX1/DDIT3/RAC1/UBE2J1/NDUFA4/PSMC4/IL6/RPS27A/MAP2K1/NDUFA3/VDAC2/GNAQ/NDUFA1/MAPK10/ATP5PB/NDUFB9/XBP1/BID/PSMA4/COX6B1/PSMD12/MAP1LC3B/SDHC	0.948285316604398
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/606	154/9376	1.30607346448931	FOS/ACTB/RHOA/RGS2/MEF2C/ROCK1/PPP1CB/MAP2K1/PIK3CG/GNAQ/EGFR/PIK3R5/PRKACB	1.00668972167281
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/606	36/9376	1.71910524385772	ENPP1/GAA/PGM2/GYG2	1.13629846917357
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/606	155/9376	1.29764718407325	FZD1/CDKN1B/FZD2/AHR/CDK6/MAP2K1/CREB5/RAP1B/ATF6B/GNAQ/EGFR/PRKACB/CREB3L2	0.982201899950273
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/606	115/9376	1.3453867125843	DUSP1/GNG10/GNG11/GNG2/GNB1/GNB2/MAP2K1/GNB4/GNAQ/PRKACB	0.979597701484947
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/606	170/9376	1.27416035721219	TGFBR1/ACTB/FZD1/HGF/FZD2/GADD45B/CDK6/GSTT2B/MAP2K1/TGFBR2/GSTM4/MGST1/EGFR/PTEN	0.948234574029727
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/606	75/9376	1.44404840484048	SLC31A1/MAP3K5/GSTT2B/GSTM4/MGST1/BID/TOP2B	1.0148883737416
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/606	226/9376	1.2322789801104	FOS/PDE4B/RHOA/ADRB2/RAC1/ATP1B1/ROCK1/PPP1CB/PAK1/ATP1B3/TIAM1/MAP2K1/CREB5/ADRB1/RAP1B/PRKACB/MAPK10/CREB3L2	0.929128403339368
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/606	62/9376	1.49728521239221	HSPA1B/HSPA1A/HSPA6/HSPA1L/PRKACB/CRYAB	1.03265541448554
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/606	157/9376	1.28111664669652	HLA-C/TGFBR1/ZFP36L1/GADD45B/CDK6/PPP1CB/IL6/MAP2K1/HIPK1/TGFBR2/ZFP36L2/VDAC2/PTEN	0.933719945495145
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/606	51/9376	1.51685756810975	ACTB/KDELR2/ATP6V0C/ATP6V0B/PRKACB	0.972867513038949
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/606	27/9376	1.71910524385772	SCP2/HACD3/ELOVL1	0.983589562503533
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/606	149/9376	1.24606286131969	RHOA/LPAR6/LPAR5/FCER1G/GNA13/ARF6/PDGFRA/MAP2K1/AGPAT5/PIK3CG/EGFR/PIK3R5	0.795849774127828
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/606	53/9376	1.4596176598792	ATP1B1/ATP1B3/GNAQ/PRKACB/SLC8A1	0.882021057192098
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/606	80/9376	1.35379537953795	GAS6/HGF/PDGFRA/IL6/MAP2K1/EGFR/PTEN	0.835355327016891
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/606	67/9376	1.38554750997488	PPP1CB/MAP2K1/RAP1B/GNAQ/PRKACB/RPS6KA1	0.832503259194036
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/606	28/9376	1.65770862800566	HACD3/PPT1/ELOVL1	0.916168501813912
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/606	69/9376	1.3453867125843	FOS/PPP1CB/CREB5/ATF6B/PRKACB/CREB3L2	0.75691562029754
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/606	29/9376	1.6005462615227	MOB1A/PAK1/MOB1B	0.85139579125984
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/606	98/9376	1.26301609752812	ATP1B1/ATP1B3/NR4A2/CREB5/ATF6B/GNAQ/PRKACB/CREB3L2	0.688003008047753
NA	NA	hsa04519	Cadherin signaling	29/606	404/9376	1.11061007090808	VIM/ACTR3/CDC42/ACTB/FZD1/RHOA/MOB1A/ACTR2/YWHAH/KRT24/TMC7/FZD2/CTNND1/APH1A/CDH11/RAC1/ROCK1/KRT10/PPP1CB/PDGFRA/MAP2K1/ARPC4/MOB1B/ARPC1B/CDH13/ARPC1A/SHOC2/EGFR/MAPK10	0.597396775916918
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/606	30/9376	1.54719471947195	IL1B/IL6/ABCC5	0.789063201667767
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/606	71/9376	1.30748849532841	TNFRSF11A/FOS/SOCS6/MAP2K1/PRL/MAPK10	0.683631413161942
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/606	157/9376	1.18256921233525	TGFBR1/ACTB/FZD1/MOB1A/YWHAH/FZD2/PPP1CB/BMP5/TGFBR2/MOB1B/PPP2CA/AMOT	0.606397796053641
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/606	73/9376	1.27166689271667	CXCR4/CHMP4B/SAMHD1/SERINC3/PDCD6IP/CDK9	0.612503801615663
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/606	73/9376	1.27166689271667	HGF/GADD45B/CDK6/MAP2K1/EGFR/JAK3	0.612503801615663
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/606	59/9376	1.31118196565419	GPX1/TXNDC12/GSTT2B/GSTM4/MGST1	0.630266946120582
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/606	116/9376	1.20040969614203	GNG10/GNG11/GNG2/GNB1/GNB2/GNB4/GNAQ/PRKACB/SLC1A3	0.570905707039627
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	22/606	308/9376	1.10513908533711	TUBB/NDUFA2/MT-ND3/NDUFB1/MAP3K5/GPX1/NDUFA4/PSMC4/NDUFA3/VDAC2/CREB5/GNAQ/NDUFA1/MAPK10/ATP5PB/NDUFB9/CREB3L2/PSMA4/COX6B1/SLC1A3/PSMD12/SDHC	0.493180561413721
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/606	60/9376	1.28932893289329	GNA13/MAP2K1/PPP2CA/GNAQ/LYN	0.590982885452871
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/606	46/9376	1.3453867125843	PSME1/PSMC4/PSMA4/PSMD12	0.617256786204849
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/606	19/9376	1.62862602049679	GLB1/IDS	0.720979627208024
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/606	235/9376	1.11924724387332	ACTB/NDUFA2/MT-ND3/NDUFB1/MAP3K5/NDUFA4/NDUFA3/CREB5/PRKACB/NDUFA1/ATP5PB/NDUFB9/NDUFAF8/CREB3L2/COX6B1/RPS6KA1/SDHC	0.486639750028446
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/606	89/9376	1.21689472318018	TUBB/PDGFRA/MAP2K1/ADRB1/GNAQ/EGFR/PRKACB	0.540416275929359
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/606	134/9376	1.15462292497906	RHOA/KCNMB4/KCNMA1/GNA13/ROCK1/PPP1CB/MAP2K1/GNAQ/PRKACB/PRKCH	0.47387680884046
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/606	76/9376	1.22146951537259	GADD45B/CDK6/PDGFRA/MAP2K1/EGFR/PTEN	0.509567159368605
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/606	105/9376	1.17881502435958	HIF1A/TOMM7/GABARAP/CSNK2B/RPS27A/AMFR/MAPK10/MAP1LC3B	0.484348008957301
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/606	20/9376	1.54719471947195	LIPA/SOAT1	0.6439230071677
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/606	122/9376	1.14137315370881	FOS/MAP2K1/CREB5/ATF6B/GNAQ/PRKACB/MAPK10/CREB3L2/JUNB	0.41314668038485
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/606	49/9376	1.26301609752812	CREB5/ATF6B/PRKACB/CREB3L2	0.485212002069597
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/606	78/9376	1.19014978420919	CNOT7/BTG2/CNOT2/C1D/DCP2/LSM5	0.443272226248956
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/606	79/9376	1.1750845970673	ATP6V0C/SYT1/ATP6V0B/NSF/VAMP2/SLC1A3	0.410782775374508
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/606	109/9376	1.1355557574106	CD36/PPP1CB/IL6/CREB5/MAPK10/CREB3L2/RPS6KA1/PTEN	0.37418277287842
NA	NA	hsa04082	Neuroactive ligand signaling	14/606	199/9376	1.08847869711594	P2RY13/OGFRL1/GNG10/GNG11/ADRB2/GNG2/GNB1/GNB2/GNB4/ADRB1/GNAQ/PRKACB/SLC1A3/P2RY12	0.331617197535822
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/606	65/9376	1.19014978420919	CREB5/ATF6B/GNAQ/PRKACB/CREB3L2	0.404367744383753
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	25/606	368/9376	1.05108336920649	HSPA5/ACTB/TUBB/NDUFA2/MT-ND3/NDUFB1/MAP3K5/GPX1/PFN1/DDIT3/RAC1/NDUFA4/PSMC4/HNRNPA3/NDUFA3/NDUFA1/ATP5PB/NDUFB9/XBP1/BID/PSMA4/COX6B1/PSMD12/MAP1LC3B/SDHC	0.262791556752898
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/606	37/9376	1.25448220497725	GADD45B/MAP2K1/NCOA4	0.407690176486939
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/606	23/9376	1.3453867125843	ATP1B1/ATP1B3	0.43592947071335
NA	NA	hsa04081	Hormone signaling	15/606	219/9376	1.05972241059722	GNG10/RHOA/GNG11/ADRB2/GNG2/ITGAV/GNA13/GNB1/SLC40A1/GNB2/GNB4/PRL/ADRB1/GNAQ/PRKACB	0.235074181660402
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/606	38/9376	1.22146951537259	NAMPT/NMRK1/ENPP1	0.359584507748056
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/606	38/9376	1.22146951537259	SGK1/ATP1B1/ATP1B3	0.359584507748056
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/606	68/9376	1.13764317608231	RUNX1/DUSP6/FCGR1A/PIM1/MAP2K1	0.299435376233034
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/606	99/9376	1.09397606427309	PTGER4/IL1B/PPP1CB/GNAQ/PRKACB/MAPK10/PRKCH	0.247088893961838
Human Diseases	Substance dependence	hsa05034	Alcoholism	13/606	191/9376	1.05306446875054	GNG10/GNG11/GNG2/GNB1/PPP1CB/HDAC9/GNB2/MAP2K1/GNB4/CREB5/ATF6B/PRKACB/CREB3L2	0.194761485152329
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/606	24/9376	1.28932893289329	HS3ST2/HS3ST3A1	0.373050297482786
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/606	86/9376	1.07943817637578	CDKN1B/PAK1/MAP2K1/CBL/EGFR/MAPK10	0.194532777648068
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/606	71/9376	1.089573746107	HIF1A/PDGFRA/MAP2K1/EGFR/PTEN	0.199147049608929
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/606	102/9376	1.06180029767683	RHOA/KCNMA1/RAC1/ATP1B1/ATP1B3/RAP1B/GNAQ	0.164960232741866
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/606	56/9376	1.10513908533711	GAS1/PTCH2/PRKACB/ARRB2	0.20743040030256
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/606	41/9376	1.1320936971746	THBS1/MAP2K1/EGFR	0.222812225580958
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/606	243/9376	1.01872903339717	HSPA1B/HSPA1A/PCBP1/HSPA6/PRPF40A/HSPA1L/HNRNPK/HNRNPA3/PRPF38B/WBP11/SF3B1/TRA2B/BCAS2/SF3B4/CDC5L/LSM5	0.0777560026064539
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/606	57/9376	1.08575068033119	SCP2/HACD3/PPT1/ELOVL1	0.170691737790946
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/606	105/9376	1.03146314631463	ACTB/ITGAV/ADRB1/ITGA4/PRKACB/LAMA2/SLC8A1	0.0852227732406853
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/606	59/9376	1.04894557252335	GADD45B/MAP2K1/EGFR/PTEN	0.0991342041803898
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/606	75/9376	1.03146314631463	THBS1/GADD45B/CDK6/BID/PTEN	0.0719101364805516
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/606	76/9376	1.01789126281049	ACTB/ATP1B1/ATP1B3/GNAQ/PRKACB	0.0411650332666404
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/606	12/9376	1.28932893289329	COQ7	0.263617319277022
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/606	93/9376	0.998190141594805	CDC42/MAP2K1/GNAQ/EGFR/PRKACB/MAPK10	-0.00461067012917921
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/606	93/9376	0.998190141594805	CDKN1B/ITGAV/GADD45B/CDK6/LAMA2/PTEN	-0.00461067012917921
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/606	63/9376	0.982345853632982	FZD1/FZD2/GADD45B/PTCH2	-0.0369567991574129
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/606	128/9376	0.966996699669967	PDE4B/ENTPD1/NME3/DCK/LACC1/NME2/ENPP1/PGM2	-0.0988235838042804
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/606	31/9376	0.998190141594805	PGM2/FBP1	-0.00265312643426624
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/606	31/9376	0.998190141594805	ALDH9A1/DPYD	-0.00265312643426624
NA	NA	hsa04981	Folate transport and metabolism	2/606	31/9376	0.998190141594805	SLCO2B1/ABCC5	-0.00265312643426624
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/606	32/9376	0.966996699669967	MAPK10/BID	-0.0491573088785652
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/606	49/9376	0.94726207314609	GALNT4/ST6GAL1/MFNG	-0.0972909084815607
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/606	99/9376	0.937693769376938	FOS/CDKN1B/MAP2K1/EGFR/PRKACB/MAPK10	-0.163820199650471
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/606	99/9376	0.937693769376938	ACTB/ITGAV/IL6/ITGA4/LAMA2/SLC8A1	-0.163820199650471
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/606	148/9376	0.940861653732941	FOS/FZD1/FZD2/HES1/GADD45B/CDK6/MAP2K1/EGFR/PTEN	-0.190619968835731
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/606	15/9376	1.03146314631463	GLB1	0.0320559616909456
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/606	150/9376	0.928316831683168	TGFBR1/FZD1/CDKN1B/HGF/FZD2/GADD45B/MAP2K1/TGFBR2/EGFR	-0.232636711646009
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/606	101/9376	0.919125575923929	FZD1/FZD2/MAP2K1/GNAQ/PRKACB/CREB3L2	-0.214801387495039
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/606	68/9376	0.910114540865851	DHRS9/DHRS4/RETSAT/RDH11	-0.19554101438067
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/606	51/9376	0.910114540865851	PLD4/PLD3/LPCAT2	-0.169189054164405
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/606	184/9376	0.924953364901708	CXCL12/CDC42/RHOA/CXCR4/DPYSL2/RAC1/ROCK1/PAK1/CFL1/MYL12A/SLIT2	-0.270244759876351
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/606	16/9376	0.966996699669967	NAGA	-0.0347297448002352
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/606	86/9376	0.899531813646481	ACTB/ITGAV/ITGA4/LAMA2/SLC8A1	-0.246032276271808
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/606	87/9376	0.889192367512613	ATP1B1/ATP1B3/ASPH/COX6B1/SLC8A1	-0.272939866204937
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/606	35/9376	0.884111268269684	AKR1B1/FBP1	-0.180551333259255
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/606	70/9376	0.884111268269684	GSTT2B/HSD11B1/GSTM4/MGST1	-0.255817858788238
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/606	122/9376	0.887734675106855	CD36/RAB14/CREB5/PPP2CA/CAB39/CREB3L2/FBP1	-0.328082419364165
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/606	122/9376	0.887734675106855	HIF1A/ACTB/ITGAV/ATP1B1/ATP1B3/MAP2K1/PRKACB	-0.328082419364165
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/606	54/9376	0.85955262192886	APIP/LACC1/MAT2B	-0.272068411054964
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/606	18/9376	0.85955262192886	LMBRD1	-0.156776340101803
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/606	144/9376	0.85955262192886	MAP3K5/PSMC4/VDAC2/GNAQ/MAPK10/XBP1/PSMA4/PSMD12	-0.446446207217493
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/606	59/9376	0.786709179392516	ADRB2/ADRB1/PRKACB	-0.431998537759802
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/606	60/9376	0.773597359735974	CDC42/RAC1/MAP2K1	-0.462449725574908
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/606	21/9376	0.736759390224737	DSE	-0.317440835246201
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/606	79/9376	0.783389731378201	GSTT2B/HSD11B1/GSTM4/MGST1	-0.508210138467389
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/606	22/9376	0.703270327032703	ALDH9A1	-0.366265311501257
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/606	62/9376	0.748642606196103	APH1A/HES1/MFNG	-0.521965196660319
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/606	23/9376	0.672693356292151	ZMPSTE24	-0.413109731074845
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/606	23/9376	0.672693356292151	CTSA	-0.413109731074845
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/606	44/9376	0.703270327032703	HMGB1/APEX1	-0.518587572082393
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/606	83/9376	0.745636009384071	MBD6/CSNK2B/UBE2D3/BMI1	-0.611841401478518
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/606	138/9376	0.784808915674176	FLOT1/PPP1CB/MAP2K1/CBL/PRKACB/MAPK10/FBP1	-0.669417392438598
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/606	156/9376	0.793433189472793	YWHAH/CD81/CDK6/MAP2K1/PPP2CA/EGFR/IFNAR1/BID	-0.683879422273103
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/606	65/9376	0.714089870525514	AKR1B1/ALDH9A1/AGPAT5	-0.608009284011992
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/606	65/9376	0.714089870525514	MAP2K1/GNAQ/ARRB2	-0.608009284011992
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/606	103/9376	0.751065397801916	PABPN1/PPP1CB/PPP2CA/NUDT21/DAZAP1	-0.667753086807739
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/606	158/9376	0.783389731378201	SGK1/FZD1/RHOA/FZD2/MAP2K1/CAB39/RPS6KA1/PTEN	-0.721790872972344
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/606	104/9376	0.743843615130744	PLD4/PLD3/LPCAT2/AGPAT5/ETNK1	-0.690489847202407
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/606	67/9376	0.692773754987439	ALDH9A1/PGM2/FBP1	-0.663386077372327
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/606	178/9376	0.782289464901546	DKK1/FZD1/RHOA/FZD2/CSNK2B/CACYBP/RAC1/PRKACB/MAPK10	-0.770841161920422
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/606	26/9376	0.595074892104595	HES1	-0.543472694326962
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/606	26/9376	0.595074892104595	LMBRD1	-0.543472694326962
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/606	48/9376	0.644664466446645	ATP1B1/ATP1B3	-0.648764597348595
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/606	107/9376	0.722988186669134	CREB5/GNAQ/PRKACB/CREB3L2/FBP1	-0.757523118769629
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/606	90/9376	0.687642097543088	CREB5/ATF6B/PRKACB/CREB3L2	-0.782675188381332
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/606	50/9376	0.618877887788779	SAT1/ALDH9A1	-0.710270205006357
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/606	28/9376	0.552569542668553	B3GNT5	-0.623257281879142
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/606	28/9376	0.552569542668553	AKR1B1	-0.623257281879142
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/606	28/9376	0.552569542668553	ATP6V0C	-0.623257281879142
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/606	29/9376	0.533515420507568	GNB1	-0.661336241874945
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/606	73/9376	0.635833446358334	GSTT2B/GSTM4/MGST1	-0.821054771511759
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/606	30/9376	0.515731573157316	SDHC	-0.69832251985153
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/606	30/9376	0.515731573157316	PIGP	-0.69832251985153
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/606	31/9376	0.499095070797402	ALDH9A1	-0.734291757248355
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/606	138/9376	0.672693356292151	YWHAH/PPP1CB/MAP2K1/PPP2CA/PRKACB/RPS6KA1	-1.0181869785413
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/606	158/9376	0.685466014955926	CDKN1B/YWHAH/GADD45B/CDK6/TFDP2/PPP2CA/RAD21	-1.04809324640478
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/606	323/9376	0.766412244939664	MARCKS/VIM/CDKN1B/RHOA/ZEB2/PLAU/THBS1/CDK6/HNRNPK/ROCK1/BMI1/PDGFRA/PIM1/MAP2K1/EGFR/PTEN	-1.12299346087999
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/606	254/9376	0.730958135183597	CXCR4/ADRB2/HGF/PDGFRA/ASPH/CYSLTR1/VDAC2/ADRB1/GNAQ/EGFR/PRKACB/SLC8A1	-1.1426516274155
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/606	142/9376	0.653744247664203	UBE2J1/UBE2D3/RPS27A/KLHL13/CBL/RNF7	-1.09286970628444
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/606	36/9376	0.42977631096443	AKR1B1	-0.901042386315605
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/606	36/9376	0.42977631096443	GALNT4	-0.901042386315605
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/606	144/9376	0.644664466446645	FZD1/FZD2/BMI1/MAP2K1/SKIL/JAK3	-1.12952056081919
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/606	83/9376	0.559227007038053	AMACR/SCP2/DHRS4	-1.06022540806462
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/606	37/9376	0.418160734992418	NAT8L	-0.93212864396225
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/606	37/9376	0.418160734992418	PGM2	-0.93212864396225
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/606	63/9376	0.491172926816491	ALDH9A1/SETDB2	-1.06516733001766
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/606	63/9376	0.491172926816491	LTC4S/TBXAS1	-1.06516733001766
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/606	38/9376	0.407156505124197	PGM2	-0.962558372505187
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/606	39/9376	0.396716594736397	MAT2B	-0.992366641269689
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/606	110/9376	0.562616261626163	MAP2K1/PRKACB/MAPK10/RPS6KA1	-1.21292788487508
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/606	66/9376	0.468846884688469	DHRS9/HSD11B1	-1.1382535511888
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/606	90/9376	0.515731573157316	ATP1B1/ATP1B3/PRKACB	-1.2134313850392
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/606	154/9376	0.602803137456603	COQ7/NME3/NME2/MAT2B/PPCS/RDH11	-1.30639877478531
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/606	42/9376	0.368379695112368	ALDH9A1	-1.07837294511467
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/606	43/9376	0.359812725458592	ALDH9A1	-1.10599403731934
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/606	43/9376	0.359812725458592	CD36	-1.10599403731934
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/606	70/9376	0.442055634134842	CD36/MAPK10	-1.2316308140358
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/606	45/9376	0.343821048771544	ABCC5	-1.15980936408521
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/606	46/9376	0.336346678146075	FTH1	-1.1860459643529
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/606	47/9376	0.329190365845095	ALDH9A1	-1.21186105040675
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/606	47/9376	0.329190365845095	MAPK10	-1.21186105040675
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/606	48/9376	0.322332233223322	ALDH9A1	-1.23727242094964
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/606	76/9376	0.407156505124197	CD36/SCP2	-1.36404134503925
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/606	78/9376	0.396716594736397	PIK3CG/PTEN	-1.40635856739155
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/606	52/9376	0.297537446052298	PRKACB	-1.33519860930216
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/606	194/9376	0.55826613589194	ACTB/TUBB/CAPZA2/CAPZA1/MYL12A/KIF20B/HOOK3	-1.6342371119218
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/606	54/9376	0.286517540642953	HES1	-1.38212647112953
NA	NA	hsa04382	Cornified envelope formation	7/606	217/9376	0.499095070797402	S100A8/KRT24/SPRR3/S100A12/KRT10/PPP2CA/ELOVL1	-1.96238084687795
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/606	370/9376	0.585425028989385	PTGER4/C3/C3AR1/P2RY13/OGFRL1/LPAR6/FPR1/ADRB2/C5AR1/CYSLTR1/GZMA/PRL/ADRB1/UTS2	-2.1387504964626
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/606	72/9376	0.214888155482215	MAPK10	-1.75786322353461
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/606	75/9376	0.206292629262926	MAT2B	-1.81404633804155
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/606	116/9376	0.266757710253784	FBP1/SDHC	-2.0887822092313
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/606	117/9376	0.264477729824265	ACTB/CDK2AP1	-2.10440279176841
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/606	86/9376	0.179906362729296	PRKACB	-2.00829249195131
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/606	98/9376	0.157877012191015	PTEN	-2.20284292179797
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/606	183/9376	0.253638478601959	TCOF1/CSNK2B/SBDS	-2.68020683083181
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/606	449/9376	0.172293398604894	RGS2/GNB1/PRKACB/ARRB2/SLC8A1	-4.72464275423885