category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	58/1095	222/9376	2.237064461722	RSL24D1/RPL41/MRPL54/RPL12/RPL39/RPL30/RPL28/RPL34/RPS4X/RPL10/RPS21/RPLP1/MRPS6/RPL37/RPS27L/MRPL51/RPS15A/RPL14/MRPL33/MRPS15/MRPL18/FAU/RPS27A/MRPS21/RPS3/RPL21/MRPS34/RPS24/RPS5/RPSA/RPS14/RPL36AL/RPS12/RPL35A/MRPL42/UBA52/MRPL52/RPS28/MRPS31/MRPS35/MRPL19/MRPS33/MRPL36/MRPL21/RPL24/RPS8/MRPL3/RPS23/RPS19/RPS13/MRPS26/MRPS10/MRPL1/RPS26/RPL18/RPL5/RPL7/RPL37A	6.78288836482087
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	62/1095	253/9376	2.09833414550508	CAST/H3-3B/DIAPH1/SEPTIN6/CAPNS1/RBX1/H3-3A/ATM/UBE2D2/SEPTIN7/GSK3B/RPS6KA5/FNBP1/CAPN1/MAPK1/ROCK1/FOXO3/ACTB/PIK3R1/VDAC1/ACTR2/ELMO1/RPS27A/U2AF1/ACTR3/ACTG1/RIPK2/CAPN2/ARF6/MYL12A/FBXW11/PRKCQ/BCL2/TAB2/ARPC4/UBE2V1/TNIP1/NFKB1/PIK3CA/UBA52/UBE2D3/RPS6KB2/MAP1LC3B/RPTOR/FOXO1/UBE2N/ATG5/MYL12B/BNIP3/BECN1/CD44/RPS6KB1/PLCD1/PRKCE/PIK3CD/GLMN/PYCARD/ATG14/PFN2/PFN1/UBE2D1/TAB3	6.43987168329271
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1095	142/9376	2.47228760692006	STUB1/RBX1/UBE2B/FBXO2/PIAS1/BIRC6/FBXW7/ELOB/RNF7/UBE2D2/ANAPC16/CBLB/UBE2G1/HUWE1/CDC27/RPS27A/HERC1/UBE2S/UBE2I/BIRC2/UBE2Q1/UBE2E2/UBE2M/FBXW11/COP1/UBR5/ELOC/MAP3K1/UBA52/UBE2D3/CDC26/UBE2N/UBE2J1/UBE2H/UBE2R2/UBE3C/UBE2K/SAE1/UBA6/UBE2D1/VHL	6.4282565194532
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	61/1095	268/9376	1.94894023035507	COX7A1/TUBA4A/TH/NDUFB2/TXN/SOD1/KLC3/COX7A2/PSMD8/COX7C/VDAC2/COX7A2L/NDUFA4/NDUFS4/UQCR11/PRKACB/ATP5PD/NDUFB4/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/ATP5F1E/SEM1/NDUFB9/COX6A1/CAMK2D/NDUFB7/UQCRH/ERN1/UBE2G1/NFE2L2/VDAC1/NDUFA1/RPS27A/COX8A/MT-ATP8/UQCR10/MAP3K5/ATF6/PINK1/COX6C/COX4I1/NDUFA4L2/MCU/ATP5PB/UBA52/PSMB7/GNAI3/NDUFA5/UBE2J1/SLC39A6/KIF5B/DDIT3/PSMD12/SLC39A8/SLC39A11/ATP5MC2	5.73120641745303
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	50/1095	205/9376	2.08842855551843	COX7A1/GAPDH/RAC2/PPP1CB/NDUFB2/PRKCB/COX7A2/COX7C/VDAC2/COX7A2L/NDUFA4/NDUFS4/UQCR11/ATP5PD/NDUFB4/PRKCA/NDUFB1/GSK3B/NDUFB11/NDUFA2/ATP5F1D/PPP1CA/NDUFB6/COX6B1/NDUFS5/ATP5F1E/TGFBR2/MPC2/NDUFB9/COX6A1/CAMK2D/NDUFB7/UQCRH/PIK3R1/TGFB1/VDAC1/NDUFA1/COX8A/MT-ATP8/UQCR10/COX6C/COX4I1/NDUFA4L2/NFKB1/PIK3CA/ATP5PB/NDUFA5/ATP5MC2/MPC1/PIK3CD	5.72954080135374
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	38/1095	138/9376	2.3578055720998	COX7A1/NDUFB2/COX7A2/COX7C/COX7A2L/NDUFA4/NDUFS4/UQCR11/ATP5PD/NDUFB4/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/ATP6V1D/ATP5F1E/NDUFB9/COX6A1/NDUFB7/UQCRH/COX11/NDUFA1/COX8A/ATP5ME/MT-ATP8/UQCR10/COX17/COX6C/COX4I1/NDUFA4L2/ATP5PB/ATP6V1G1/NDUFA5/LHPP/ATP5MC2	5.84304803074671
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	76/1095	368/9376	1.76835417907485	COX7A1/TUBA4A/PPP3CA/OPTN/NDUFB2/SOD1/CHMP2B/KLC3/COX7A2/PSMD8/COX7C/COX7A2L/NDUFA4/DCTN3/NDUFS4/UQCR11/ATP5PD/NDUFB4/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/ATP5F1E/SEM1/NDUFB9/NRBF2/COX6A1/NDUFB7/UQCRH/ERN1/ACTB/VDAC1/NDUFA1/COX8A/PPP3CC/ACTG1/NUP98/MT-ATP8/UQCR10/BCL2/SETX/MAP3K5/ATF6/PINK1/COX6C/COX4I1/NDUFA4L2/MCU/ATP5PB/PSMB7/ACTR10/RAB8A/MAP1LC3B/NDUFA5/PPP3CB/KIF5B/DDIT3/NXT1/AMBRA1/VCP/DCTN6/BECN1/ATG13/NUP153/PSMD12/RAB5A/ATP5MC2/ALYREF/ATG14/NUP54/NUP58/PFN2/PFN1	5.46792417899678
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	66/1095	308/9376	1.83483365949119	COX7A1/TUBA4A/POLR2L/NDUFB2/POLR2I/AP2S1/SOD1/KLC3/COX7A2/PSMD8/CLTB/COX7C/VDAC2/COX7A2L/NDUFA4/DCTN3/NDUFS4/UQCR11/ATP5PD/NDUFB4/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/ATP5F1E/SEM1/NDUFB9/NRBF2/COX6A1/NDUFB7/UQCRH/ERN1/VDAC1/POLR2K/NDUFA1/GNAQ/COX8A/CREB1/MT-ATP8/UQCR10/MAP3K5/COX6C/COX4I1/NDUFA4L2/CASP8/ATP5PB/PSMB7/ACTR10/NRF1/NDUFA5/HTT/TAF4B/REST/KIF5B/AMBRA1/IFT57/DCTN6/BECN1/ATG13/PSMD12/ATP5MC2/TGM2/ATG14	5.41714997095508
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	56/1095	248/9376	1.93348063043158	S100A10/ANXA2/GAPDH/TUBA4A/AHNAK2/DYNLT1/TXN/KLC3/AHNAK/RHOH/DCTN3/BRK1/EXOC4/PTPRC/TCF7/CYFIP2/KPNA4/RAB9A/MAPK1/MAP2K4/ACTB/ACTR2/ELMO1/ACTR3/ACTG1/RIPK2/RPS3/BIRC2/ARF6/DYNLL1/RAB7A/MYL12A/BCL2/TAB2/ARPC4/DYNLT3/CASP8/NFKB1/PIK3CA/ACTR10/LEF1/KIF5B/IRAK4/MYL12B/DCTN6/ACBD3/DYNLL2/RAB5A/VPS41/RRAS/PIK3CD/PYCARD/NCKAP1/PFN2/PFN1/TAB3	5.41744662321472
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	33/1095	117/9376	2.41508020138157	BAZ1A/H2AZ1/EPC1/MBD2/H2AJ/RSF1/H2AZ2/ARID1B/MACROH2A1/BPTF/H2AX/ACTB/ARID2/ACTG1/BRD7/H2AC6/PBRM1/MORF4L1/ZNHIT1/BICRAL/SMARCC2/POLE3/YEATS4/UCHL5/GATAD2A/CHRAC1/CHD3/BRD9/ACTL6A/TRRAP/SMARCD1/CDK2AP2/H2AC20	5.600712104156
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	53/1095	235/9376	1.93112989410279	COX7A1/NDUFB2/COX7A2/COX7C/COX7A2L/NDUFA4/NDUFS4/UQCR11/PRKACB/ACSL3/ATP5PD/NDUFB4/ARID1B/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/ATP5F1E/NDUFB9/COX6A1/NDUFAF8/NDUFB7/UQCRH/COX11/ACTB/NDUFA1/SOS1/COX8A/CREB1/ACTG1/RPS6KA3/ATP5ME/MT-ATP8/UQCR10/COX17/SMARCC2/MAP3K5/COX6C/COX4I1/NDUFA4L2/COA1/ATP5PB/RPS6KB2/RPTOR/SOS2/NDUFA5/ACTL6A/SMARCD1/RPS6KB1/ATP5MC2	5.25652400574167
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/1095	388/9376	1.6992703478793	COX7A1/GAPDH/TUBA4A/PPP3CA/BRAF/NDUFB2/WNT5A/RTN3/KLC3/COX7A2/PSMD8/COX7C/VDAC2/COX7A2L/NDUFA4/NDUFS4/UQCR11/ATP5PD/NDUFB4/NDUFB1/GSK3B/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/WNT2/CAPN1/COX6B1/NDUFS5/MAPK1/ATP5F1E/SEM1/NDUFB9/NRBF2/COX6A1/NDUFB7/UQCRH/ERN1/PIK3R1/VDAC1/NDUFA1/GNAQ/COX8A/PPP3CC/CAPN2/MT-ATP8/UQCR10/MAP3K5/ATF6/PSENEN/COX6C/COX4I1/NDUFA4L2/CASP8/NFKB1/PIK3CA/MCU/ATP5PB/CSNK1A1/PSMB7/RTN4/NDUFA5/PPP3CB/SLC39A6/KIF5B/DDIT3/AMBRA1/BECN1/ATG13/PSMD12/NAE1/PSEN1/SLC39A8/SLC39A11/ATP5MC2/PIK3CD/ATG14	5.11541354419503
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	33/1095	122/9376	2.31610150460364	PPP2R5C/CD247/FYN/PPP3CA/CD3G/CD3E/CD3D/ITK/NFATC3/PTPRC/GSK3B/LCK/CBLB/MAPK1/PIK3R1/SOS1/NFATC2/PPP3CC/RASGRP1/CARD11/PPP2R2B/DLG1/PRKCQ/VAV3/NFKB1/PIK3CA/SOS2/PPP3CB/PTPN6/PIK3CD/ICOS/NCK1/PPP2R1A	5.32054179188139
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	51/1095	227/9376	1.92374630378372	COX7A1/BRAF/NDUFB2/SOD1/COX7A2/COX7C/VDAC2/COX7A2L/NDUFA4/NDUFS4/UQCR11/ATP5PD/NDUFB4/NDUFB1/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/MAPK1/MAP2K4/ATP5F1E/NDUFB9/COX6A1/FOXO3/NDUFB7/UQCRH/PIK3R1/NFE2L2/VDAC1/NDUFA1/SOS1/COX8A/PTPRJ/MT-ATP8/UQCR10/MAP3K5/GSTO2/COX6C/COX4I1/NDUFA4L2/NFKB1/MGST3/PIK3CA/ATP5PB/PTPN1/SOS2/NDUFA5/ATP5MC2/PIK3CD	5.12306815903403
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	39/1095	157/9376	2.12700462437833	PPP3CA/ZFP36L2/PPP1CB/CCND3/CCND1/VDAC2/ATM/NFATC3/CDK6/PPP1CA/ETS1/CAPN1/MAPK1/TGFBR2/FOXO3/PIK3R1/TGFB1/VDAC1/NFATC2/CCND2/PPP3CC/CAPN2/RBL2/FBXW11/RB1/IGFBP3/RRAS2/NFKB1/PIK3CA/MCU/GADD45A/TRPM7/FOXO1/PPP3CB/RASSF5/RRAS/HIPK2/PIK3CD/ATR	5.17827275463803
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	88/1095	480/9376	1.56980213089802	COX7A1/TUBA4A/PPP3CA/OPTN/BRAF/NDUFB2/WNT5A/PRKCB/SOD1/CHMP2B/KLC3/COX7A2/PSMD8/ATXN1/COX7C/VDAC2/COX7A2L/NDUFA4/DCTN3/NDUFS4/UQCR11/ATP5PD/NDUFB4/PRKCA/NDUFB1/GSK3B/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/WNT2/CAPN1/COX6B1/NDUFS5/MAPK1/ATP5F1E/SEM1/NDUFB9/NRBF2/COX6A1/CAMK2D/NDUFB7/UQCRH/ERN1/UBE2G1/VDAC1/NDUFA1/GNAQ/RPS27A/COX8A/PPP3CC/CAPN2/MT-ATP8/UQCR10/BCL2/MAP3K5/ATF6/PINK1/COX6C/COX4I1/NDUFA4L2/CASP8/NFKB1/MCU/ATP5PB/UBA52/CSNK1A1/PSMB7/ACTR10/RAB8A/MAP1LC3B/NDUFA5/HTT/PPP3CB/UBE2J1/KIF5B/DDIT3/AMBRA1/VCP/IFT57/DCTN6/BECN1/ATG13/PSMD12/RAB5A/PSEN1/ATP5MC2/ATG14	4.66013615973519
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	57/1095	275/9376	1.77478455790785	COX7A1/RAC2/TUBA4A/FYN/PPP3CA/NDUFB2/SOD1/KLC3/COX7A2/PSMD8/COX7C/VDAC2/COX7A2L/NDUFA4/NDUFS4/UQCR11/PRKACB/ATP5PD/NDUFB4/NDUFB1/GSK3B/NDUFB11/NDUFA2/ATP5F1D/NDUFB6/COX6B1/NDUFS5/MAPK1/ATP5F1E/SEM1/NDUFB9/COX6A1/NDUFB7/UQCRH/PIK3R1/VDAC1/NDUFA1/COX8A/CREB1/PPP3CC/CAV2/MT-ATP8/UQCR10/COX6C/COX4I1/NDUFA4L2/PIK3CA/MCU/ATP5PB/PSMB7/NDUFA5/PPP3CB/KIF5B/DDIT3/PSMD12/ATP5MC2/PIK3CD	4.741918129402
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	51/1095	238/9376	1.83483365949119	RSL24D1/RPL41/RPL12/PRKCB/RPL39/RPL30/JAK1/STAT3/RPL28/RPL34/RPS4X/RPL10/RPS21/RPLP1/PRKCA/RPL37/RPS27L/RPS15A/MAPK1/RPL14/PIK3R1/FAU/RPS27A/RPS3/RPL21/TAB2/RPS24/RPS5/RPSA/RPS14/TRAF3/RPL36AL/RPS12/RPL35A/NFKB1/PIK3CA/UBA52/RPS28/IRAK4/RPL24/RPS8/RPS23/RPS19/RPS13/RPS26/RPL18/PIK3CD/SYK/RPL5/RPL7/RPL37A	4.74366660311111
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	37/1095	157/9376	2.0179274641538	COX7A1/NDUFB2/COX7A2/COX7C/COX7A2L/NDUFA4/NDUFS4/UQCR11/NDUFB4/NDUFB1/GSK3B/NDUFB11/NDUFA2/NDUFB6/COX6B1/NDUFS5/NDUFB9/COX6A1/NDUFB7/UQCRH/ERN1/PIK3R1/TGFB1/NDUFA1/COX8A/ADIPOR1/UQCR10/MAP3K5/COX6C/COX4I1/NDUFA4L2/CASP8/NFKB1/PIK3CA/NDUFA5/DDIT3/PIK3CD	4.67709354496483
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	39/1095	169/9376	1.97597471022129	OPTN/BIRC6/PRKACB/MAPK1/NRBF2/ERN1/PIK3R1/UVRAG/IGF1R/RPS27A/RAB7A/VAMP8/PRKCQ/BCL2/LAMP1/RRAS2/PIK3CA/UBA52/MTMR3/ATG3/WDR45/RAB8A/RPS6KB2/MAP1LC3B/RPTOR/ATG5/AMBRA1/BNIP3/BECN1/ATG13/EPG5/ATG7/VPS41/GABARAPL2/RRAS/RPS6KB1/PIK3CD/HMGB1/ATG14	4.65558382273251
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	39/1095	170/9376	1.96435132957293	BRAF/WNT5A/PRKCB/CCND1/IGF2/PRKCA/ARID1B/TCF7/GSK3B/CDK6/GSTP1/WNT2/MAPK1/TGFBR2/ACTB/PIK3R1/ARID2/TGFB1/NFE2L2/SOS1/IGF1R/TXNRD2/ACTG1/BRD7/PBRM1/SMARCC2/GSTO2/RB1/MGST3/PIK3CA/CSNK1A1/GADD45A/RPS6KB2/SOS2/LEF1/ACTL6A/SMARCD1/RPS6KB1/PIK3CD	4.61397847855428
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	25/1095	90/9376	2.37848807711821	CD247/PPP3CA/CD3G/JAK1/CD3E/STAT3/CD3D/EML4/NFATC3/LCK/MAPK1/PIK3R1/NFATC2/PPP3CC/RASGRP1/PRKCQ/NFKB1/PIK3CA/RPS6KB2/PPP3CB/PTPN6/IFNGR1/RPS6KB1/PIK3CD/BATF	4.77816601102018
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	44/1095	203/9376	1.85592370155431	THBS1/RAC2/EMP1/FYN/PPP1CB/BRAF/DIAPH1/EMP2/PRKCB/CCND3/LAMB3/RAP1A/ITGA4/CCND1/ITGA6/PPP1R12A/PRKCA/ITGB6/GSK3B/ITGB4/PPP1CA/MAPK1/FLNB/RAP1B/ROCK1/ACTB/PIK3R1/SOS1/IGF1R/CCND2/ACTG1/CAPN2/CAV2/BIRC2/MYL12A/BCL2/VAV3/PIK3CA/SOS2/MYL12B/ITGAV/VEGFB/LAMC2/PIK3CD	4.48310262201731
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	48/1095	232/9376	1.77156353330184	RAC2/TMSB4X/CYRIB/EZR/PPP1CB/BRAF/MYH14/DIAPH1/GSN/PIP4K2A/SSH2/IQGAP2/ITGA4/BRK1/ITGA6/PPP1R12A/ITGB6/ITGB4/CYFIP2/PPP1CA/MAPK1/ROCK1/ACTB/PIK3R1/ACTR2/SOS1/DIAPH2/ACTR3/ACTG1/MYL12A/ARPC4/ITGAL/CFL1/RGCC/VAV3/RRAS2/PIK3CA/FGD3/SOS2/CYRIA/MYL12B/ITGAV/RRAS/PIK3CD/NCKAP1/TIAM1/PFN2/PFN1	4.32711943407502
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	38/1095	174/9376	1.86998372959639	CRYAB/STUB1/RBX1/SELENOS/SSR4/FBXO2/DNAJC1/UBE2D2/SEC31A/DAD1/OSTC/MARCHF6/CAPN1/BAG1/KRTCAP2/ERN1/UBE2G1/NFE2L2/SEC61G/UBXN1/SEC61B/MAN1A2/CAPN2/BCL2/MAP3K5/ATF6/ERO1B/SEC63/UBE2D3/AMFR/NGLY1/UBE2J1/DDIT3/VCP/MBTPS1/SEC24B/FBXO6/UBE2D1	4.21207354588488
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/1095	31/9376	3.314538223597	SPCS2/SPCS1/IMMP2L/SEC11C/TMEM208/SRP9/SRP14/SEC61G/SEC61B/SRP19/SEC63/IMMP1L	4.69360844796532
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	20/1095	73/9376	2.34590604866454	STK4/BRAF/PRKCB/STAT3/CCND1/EML4/PRKCA/CDK6/MAPK1/FOXO3/PIK3R1/FHIT/SOS1/RB1/PIK3CA/GADD45A/SOS2/RASSF5/KIF5B/PIK3CD	4.19774419723922
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	34/1095	158/9376	1.84257557366626	SFN/PPP2R5C/CCND3/RBX1/NIPBL/STAG1/CCND1/TFDP2/ATRX/ATM/ANAPC16/CCNH/GSK3B/CDK6/YWHAZ/PDS5A/TGFB1/CDC14A/YWHAQ/CDC27/CCND2/RBL2/RAD21/RB1/CDKN1B/GADD45A/CDC26/WAPL/DBF4/CDKN2D/MAD2L2/ATR/PPP2R1A/ESCO1	3.88392076866225
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/1095	75/9376	2.28334855403349	PERP/SFN/THBS1/CCND3/CCND1/ATM/CDK6/SERPINB5/CCND2/PMAIP1/TP53I3/BCL2/COP1/CASP8/IGFBP3/GADD45A/CCNG1/CCNG2/ATR/SESN3	4.05753000984821
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	25/1095	105/9376	2.03870406610133	TOMM7/OPTN/ARIH1/USP15/FIS1/TOMM20/FOXO3/HUWE1/RPS27A/RAB7A/PINK1/TBC1D15/RRAS2/UBA52/BNIP3L/AMFR/MAP1LC3B/AMBRA1/VCP/BNIP3/BECN1/RAB5A/MTX1/GABARAPL2/RRAS	3.89201491740025
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	30/1095	138/9376	1.86142545165773	RAC2/ITGA4/FYB1/NFATC3/GSK3B/LCK/MAPK1/MAP2K4/ROCK1/ACTB/PIK3R1/ACTR2/ELMO1/GNAQ/NFATC2/WIPF1/ACTR3/ACTG1/RPS6KA3/ARF6/TAB2/ARPC4/VAV3/NFKB1/PIK3CA/SKAP2/IRAK4/PKN2/PIK3CD/PYCARD	3.70697424754261
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	47/1095	250/9376	1.60976073059361	ARF5/SH3KBP1/VPS37B/AP2S1/RAB11FIP1/CHMP2B/ACAP2/ASAP1/RAB10/ARAP2/CLTB/IL2RG/RAB11A/RABEP1/SH3GLB2/SMAP2/VPS4B/CBLB/TGFBR2/CHMP4B/RAB22A/ACTR2/IGF2R/IGF1R/ASAP2/WIPF1/ACTR3/CAV2/RAB4A/ARFGEF1/ARF6/RAB7A/ARPC4/CHMP4C/SMAP1/CHMP2A/STAM/GBF1/WASHC3/ARFGAP3/RAB8A/CHMP3/KIF5B/GRK6/RAB5A/GRK5/PSD4	3.55337080149132
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	29/1095	133/9376	1.86702372369279	CD247/RAC2/CD48/FYN/PPP3CA/BRAF/HCST/PRKCB/PRKCA/LCK/PRF1/MAPK1/PIK3R1/SOS1/NFATC2/PPP3CC/GZMB/ITGAL/VAV3/PIK3CA/SOS2/PPP3CB/KLRD1/PTPN6/IFNGR1/SH2D1A/PIK3CD/SYK/LAT2	3.66185910596208
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	22/1095	91/9376	2.07006874404135	IFITM1/RAC2/PPP3CA/PRKCB/NFATC3/GSK3B/MAPK1/DAPP1/PIK3R1/SOS1/NFATC2/PPP3CC/LYN/CARD11/VAV3/NFKB1/PIK3CA/SOS2/PPP3CB/PTPN6/PIK3CD/SYK	3.72986167892678
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	40/1095	204/9376	1.67893276031874	THBS1/EZR/PPP1CB/BRAF/WNT5A/PRKCB/STAT3/CCND1/IGF2/PPP1R12A/PRKACB/PRKCA/LUM/PPP1CA/WNT2/MAPK1/PDCD4/ROCK1/CAMK2D/ACTB/PIK3R1/TGFB1/SOS1/IGF1R/ACTG1/CAV2/VAV3/RRAS2/PIK3CA/RPS6KB2/SOS2/NUDT16L1/ITGAV/ANK3/PTPN6/CD44/RRAS/RPS6KB1/PIK3CD/TIAM1	3.56501310943752
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/1095	224/9376	1.64370515329419	PPP3CA/CD3G/CCND3/JAK1/CD3E/CD3D/CCND1/VDAC2/IL2RG/ATM/ANAPC16/PRKACB/NFATC3/KAT2B/LCK/ETS1/MAPK1/MAP2K4/TGFBR2/TSPO/PIK3R1/TGFB1/RELB/VDAC1/NFATC2/CDC27/CREB1/CCND2/PPP3CC/DLG1/ITGAL/RB1/NFKB1/PIK3CA/MAP3K1/PPP3CB/CDC26/CRTC3/POLB/XPO1/TRRAP/PIK3CD/ATR	3.54571883915089
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	17/1095	63/9376	2.31053127491484	POLR2L/POLR2I/RBX1/CCNH/ERCC6/RPA2/POLR2K/CETN2/POLE4/ERCC1/XPA/RFC1/POLE3/GTF2H5/RPA3/XPC/MNAT1	3.79510825195964
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/1095	93/9376	2.02555113664261	RAC2/LMO7/FYN/RAP1A/TCF7/MAPK1/RAP1B/TGFBR2/ROCK1/ACTB/IGF1R/PDCD10/ACTG1/PTPRJ/CCM2/MYL12A/PTPN1/LEF1/MYL12B/PTPN6/YES1/FER	3.61414793165304
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1095	98/9376	1.92220669089554	RAC2/PRKCB/GSN/ASAP1/PTPRC/PRKCA/MAPK1/PIK3R1/ACTR2/ASAP2/ACTR3/LYN/ARF6/ARPC4/CFL1/VAV3/PIK3CA/RPS6KB2/RPS6KB1/PRKCE/PIK3CD/SYK	3.3370708554897
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1095	196/9376	1.61640108098034	GNG2/PPP3CA/JAK1/STAT3/CCND1/NFATC3/TCF7/GSK3B/CDK6/PIK3R5/MAPK1/MAP2K4/PIK3R1/NFATC2/RPS27A/CREB1/GNB1/PPP3CC/LYN/CLEC2B/TRAF3/RB1/CASP8/GNB5/NFKB1/PIK3CA/UBA52/ATG3/PREX1/MAP1LC3B/PPP3CB/LEF1/BECN1/IFNGR1/PIK3CD/SYK/ATG14	3.17118363932652
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/1095	87/9376	1.96840392589094	RAC2/BRAF/CCND1/TCF7/GSK3B/AREG/MAPK1/TGFBR2/PIK3R1/TGFB1/SOS1/PMAIP1/BCL2/PIK3CA/GADD45A/RPS6KB2/SOS2/LEF1/RPS6KB1/PIK3CD	3.2997648479355
NA	NA	hsa04382	Cornified envelope formation	40/1095	217/9376	1.57835153504619	S100A6/S100A4/KRT6A/KRT24/SPRR3/KRT5/KRT17/S100A10/KRT14/KRT19/S100A14/PPP2R5C/PPL/DSG1/KRT18/EVPL/KRT10/LAMB3/PLEC/S100A11/KRT16/DSG2/ITGA6/PKP3/JUP/ITGB4/KRT8/CAPN1/S100A16/ELOVL1/DST/COL17A1/KDSR/DSP/PPP2R2B/PKP1/COL7A1/LAMC2/TMEM79/PPP2R1A	3.13436114880788
Organismal Systems	Immune system	hsa04611	Platelet activation	26/1095	126/9376	1.76687685728782	FYN/PPP1CB/RAP1A/APBB1IP/PPP1R12A/PRKACB/PIK3R5/PPP1CA/MAPK1/RAP1B/STIM1/ROCK1/ACTB/PIK3R1/GNAQ/LYN/RASGRP1/ACTG1/MYL12A/VAMP8/PIK3CA/GNAI3/MYL12B/GUCY1A1/PIK3CD/SYK	3.15131156689276
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/1095	120/9376	1.78386605783866	BRAF/ARHGDIB/RAP1A/GSK3B/RPS6KA5/MAPK1/RAP1B/CAMK2D/FOXO3/PIK3R1/CAMK4/SOS1/RIPK2/RPS6KA3/KIDINS220/BCL2/MAP3K5/NFKB1/PIK3CA/MAP3K1/SOS2/IRAK4/PSEN1/MATK/PIK3CD	3.14247705253968
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1095	214/9376	1.56046600947382	CD247/RAC2/GNG2/PPP3CA/CD3G/PRKCB/CD3E/RBX1/CD3D/ELOB/RNF7/ATM/NFATC3/PRKCA/MAPK1/PIK3R1/GNAQ/NFATC2/GNB1/PPP3CC/FBXW11/BCL2/TAB2/CFL1/CASP8/GNB5/NFKB1/ELOC/PIK3CA/APOBEC3C/RPS6KB2/GNAI3/PPP3CB/IRAK4/AP1M2/RPS6KB1/APOBEC3G/PIK3CD/ATR	3.01586798846255
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1095	78/9376	1.97597471022129	CNOT2/XRN1/CNOT6L/ZCCHC7/TOB1/BTG1/PAN3/XRN2/LSM8/LSM5/HSPA9/TENT4B/LSM4/EXOSC7/ENO1/LSM1/LSM6/DDX6	3.14733086024798
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1095	110/9376	1.79035284350353	GAPDH/PRKCB/STAT3/RBX1/ELOB/PRKCA/MAPK1/CAMK2D/PIK3R1/IGF1R/ENO1/BCL2/PGK1/PDK1/NFKB1/ELOC/CDKN1B/PIK3CA/RPS6KB2/IFNGR1/RPS6KB1/PIK3CD/VHL	3.0319533872027
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1095	67/9376	2.04478974988073	PPP3CA/PPP1CB/BRAF/PRKCB/RAP1A/PRKACB/PRKCA/PPP1CA/MAPK1/RAP1B/CAMK2D/CAMK4/GNAQ/PPP3CC/RPS6KA3/PPP3CB	3.12080113235874
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1095	80/9376	1.92657534246575	BRAF/PRKCB/JAK1/STAT3/PRKCA/GSK3B/MAPK1/FOXO3/PIK3R1/SOS1/IGF1R/BCL2/PIK3CA/RPS6KB2/SOS2/RPS6KB1/GAS6/PIK3CD	3.02641848035691
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1095	68/9376	2.01471931238249	BRAF/STAT3/CCND1/TCF7/JUP/MAPK1/PIK3R1/SOS1/NFKB1/PIK3CA/RPS6KB2/SOS2/PIM2/LEF1/RPS6KB1/PIK3CD	3.05367983033369
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	37/1095	205/9376	1.54543713108364	REL/RASA2/PKM/GSN/CCND3/JAK1/STAT3/CCND1/H4C3/PRKACB/CDK6/KAT2B/MAPK1/YWHAZ/PIK3R1/YWHAQ/CREB1/CCND2/LYN/RBL2/PMAIP1/UBR4/DLG1/TRAF3/RB1/CASP8/NFKB1/CDKN1B/PIK3CA/SND1/SP100/POLB/HDAC4/PIK3CD/USP7/SYK/TRAF1	2.87120755999324
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/1095	93/9376	1.84141012422055	CD247/STAT4/PPP3CA/CD3G/RUNX3/JAK1/CD3E/CD3D/IL2RG/NFATC3/LCK/MAPK1/MAML2/NFATC2/PPP3CC/PRKCQ/NFKB1/PPP3CB/IFNGR1/TBX21	2.96521602041126
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	35/1095	193/9376	1.55279532495801	RAC2/GNG2/BRAF/PRKCB/STAT3/RAP1A/ITK/PRKACB/GSK3B/PIK3R5/MAPK1/RAP1B/ROCK1/FOXO3/PIK3R1/ELMO1/GNAQ/SOS1/DOCK2/GNB1/LYN/VAV3/GNB5/NFKB1/PIK3CA/CCR7/CX3CR1/PREX1/GNAI3/SOS2/GRK6/XCL2/GRK5/PIK3CD/TIAM1	2.82164276772974
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	26/1095	133/9376	1.67388333848319	STK4/BRAF/STAT3/CCND1/IL7R/ATM/MAPK1/TGFBR2/FOXO3/PIK3R1/TGFB1/SOS1/IGF1R/CCND2/RBL2/CDKN1B/PIK3CA/GADD45A/SOS2/FOXO1/BNIP3/CDKN2D/GABARAPL2/PIK3CD/USP7/CCNG2	2.84613416213184
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/1095	76/9376	1.91530881999519	BRAF/CAMK1D/PRKCB/CCND1/PRKCA/CDK6/MAPK1/CAMK2D/PIK3R1/CAMK4/SOS1/IGF1R/RB1/PIK3CA/GADD45A/SOS2/PIK3CD	2.91329373307817
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	31/1095	168/9376	1.57999565122853	STAT4/H2AZ1/CHMP2B/JAK1/STAT3/H2AJ/VDAC2/H2AZ2/MACROH2A1/VPS4B/CAPN1/H2AX/CYLD/CHMP4B/CAMK2D/VDAC1/CAPN2/H2AC6/BIRC2/BCL2/CHMP4C/CHMP2A/CASP8/CHMP3/DNM1L/TRPM7/IFNGR1/PYCARD/H2AC20/HMGB1/TNFAIP3	2.75834146651701
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1095	77/9376	1.89043467947578	RAC2/BRAF/JAK1/STAT3/CCND1/CDK6/MAPK1/TGFBR2/PIK3R1/TGFB1/RB1/NFKB1/PIK3CA/GADD45A/RPS6KB2/RPS6KB1/PIK3CD	2.85286098783257
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1095	109/9376	1.72822252942901	CD247/PPP3CA/CD3G/RORA/JAK1/CD3E/STAT3/CD3D/IL2RG/NFATC3/LCK/MAPK1/TGFBR2/TGFB1/NFATC2/PPP3CC/IL21R/PRKCQ/NFKB1/PPP3CB/IFNGR1/TBX21	2.78073167396652
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	23/1095	116/9376	1.69774838608093	RAC2/EZR/CD99/PRKCB/RAP1A/ITGA4/RHOH/ITK/PRKCA/TXK/RAP1B/ROCK1/ACTB/PIK3R1/ACTG1/MYL12A/ITGAL/VAV3/PIK3CA/GNAI3/RASSF5/MYL12B/PIK3CD	2.74962613673721
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	18/1095	86/9376	1.79216310927047	BRAF/PRKCB/PRKCA/GSK3B/AREG/CBLB/MAPK1/MAP2K4/CAMK2D/PIK3R1/SOS1/CDKN1B/PIK3CA/RPS6KB2/SOS2/RPS6KB1/PIK3CD/NCK1	2.68353514681514
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1095	75/9376	1.82667884322679	ATM/GSTP1/MAPK1/PIK3R1/REV3L/ERCC1/PMAIP1/BIRC2/BCL2/MAP3K5/XPA/GSTO2/CASP8/MGST3/PIK3CA/PIK3CD	2.61368916835338
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/1095	205/9376	1.4618999888629	CD247/CD3G/RUNX3/CCND3/JAK1/CD3E/STAT3/PSMD8/CD3D/CCND1/CDK6/CIR1/MAP2K4/SEM1/PIK3R1/RELB/CCND2/LYN/BCL2/TAB2/ITGAL/TRAF3/RB1/CASP8/NFKB1/CDKN1B/PIK3CA/GADD45A/IRAK4/PSMD12/CD44/PIK3CD/USP7/SYK/TNFAIP3	2.43146398439931
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1095	70/9376	1.83483365949119	BRAF/RBX1/RAP1A/ELOB/ETS1/MAPK1/RAP1B/PIK3R1/TGFB1/SOS1/ELOC/PIK3CA/SOS2/PIK3CD/VHL	2.54928712352328
Human Diseases	Infectious disease: viral	hsa05162	Measles	25/1095	136/9376	1.57399946279882	CD3G/CCND3/JAK1/CD3E/STAT3/CD3D/CCND1/IL2RG/GSK3B/CDK6/CBLB/RAB9A/PIK3R1/CCND2/BCL2/TAB2/TRAF3/CASP8/NFKB1/CDKN1B/PIK3CA/EIF3H/IRAK4/PIK3CD/TNFAIP3	2.45186333901485
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	48/1095	300/9376	1.37000913242009	STK4/RAC2/PPP3CA/RASA2/BRAF/PRKCB/RAP1A/IGF2/PRKACB/NFATC3/PRKCA/RPS6KA5/AREG/MAP3K2/MAPK1/MAP2K4/RAP1B/TGFBR2/TGFB1/RELB/TAOK3/SOS1/IGF1R/PPP3CC/RASGRP1/MAP4K4/RPS6KA3/MAP3K13/TAB2/MAP3K5/PPM1A/DUSP2/RRAS2/MAPKAPK3/NFKB1/MAP3K1/GADD45A/TAOK1/SOS2/PPP3CB/IRAK4/DDIT3/VEGFB/DUSP10/FLT3LG/RRAS/PTPN7/MAP3K4	2.36852041559239
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1095	103/9376	1.66263244225739	PPP2R5C/PPP1CB/SRRM1/UPF3A/RNMT/WDR33/PPP1CA/MSI2/SMG1/RNGTT/PPP2R2B/SAP18/HBS1L/DAZAP1/NXT1/SMG6/UPF3B/ALYREF/FIP1L1/PPP2R1A	2.45885253142513
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1095	77/9376	1.77923263950661	BRAF/CCND1/CDK6/MAPK1/TGFBR2/PIK3R1/TGFB1/SOS1/RB1/NFKB1/CDKN1B/PIK3CA/GADD45A/SOS2/CTBP2/PIK3CD	2.49658110688477
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1095	59/9376	1.88666511879885	BRAF/CCND1/TCF7/GSK3B/MAPK1/FOXO3/PIK3R1/SOS1/PIK3CA/GADD45A/SOS2/LEF1/PIK3CD	2.48427052877031
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/1095	125/9376	1.57551050228311	PPP2R5C/RAC2/FYN/CERS6/PRKCB/PRKCA/ORMDL2/MAPK1/ROCK1/PIK3R1/GNAQ/NSMAF/PPP2R2B/BCL2/MAP3K5/SGMS2/NFKB1/PIK3CA/GNAI3/S1PR5/PRKCE/PIK3CD/PPP2R1A	2.35540300514546
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	20/1095	105/9376	1.63096325288106	PRKCB/ATM/LCK/CYLD/RELB/LYN/UBE2I/BIRC2/CARD11/PRKCQ/BCL2/TAB2/TRAF3/NFKB1/GADD45A/IRAK4/SYK/TNFAIP3/TRAF1/TAB3	2.36421370887838
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1095	106/9376	1.61557680709916	BRAF/CCND1/TCF7/GSK3B/GSTP1/MAPK1/SPINT1/PIK3R1/SOS1/IGF1R/CREB1/BCL2/RB1/NFKB1/CDKN1B/PIK3CA/SOS2/FOXO1/LEF1/PIK3CD	2.317643426034
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1095	93/9376	1.6572691117985	LAMB3/CCND1/ITGA6/CDK6/PIK3R1/FHIT/BIRC2/BCL2/TRAF3/RB1/NFKB1/CDKN1B/PIK3CA/GADD45A/ITGAV/LAMC2/PIK3CD/TRAF1	2.31628410916948
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/1095	163/9376	1.47086870045102	STAT4/BRAF/PRKCB/JAK1/STAT3/NFATC3/PRKCA/MAPK1/MAP2K4/YWHAZ/TGFBR2/PIK3R1/TGFB1/YWHAQ/SOS1/NFATC2/CREB1/BCL2/TAB2/TRAF3/RB1/CASP8/NFKB1/PIK3CA/MAP3K1/SOS2/IRAK4/PIK3CD	2.2051817778345
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1095	101/9376	1.61077806410778	DIAPH1/PRKCB/STAT3/CCND1/PRKCA/MAPK1/TGFBR2/PIK3R1/TGFB1/F3/BCL2/NFKB1/CDKN1B/PIK3CA/FOXO1/VEGFB/PLCD1/PRKCE/PIK3CD	2.24408066738861
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1095	108/9376	1.58565871807881	SRRM1/THOC7/UPF3A/KPNA4/SUMO1/SUMO2/UBE2I/IPO7/NUP98/SAP18/NXT1/XPO1/NUP153/XPO4/SENP2/TNPO3/UPF3B/ALYREF/NUP54/NUP58	2.22594681379783
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1095	62/9376	1.79537487111504	CRYAB/SOD1/PRKACB/FOXO3/PIK3R1/IGF1R/PIK3CA/RPS6KB2/RPTOR/FOXO1/ATG5/RPS6KB1/PIK3CD	2.28481425295542
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/1095	137/9376	1.5000099990001	TUBA4A/CTSW/ATM/PRF1/CAPN1/MAPK1/ERN1/ACTB/PIK3R1/ACTG1/CAPN2/PMAIP1/BIRC2/GZMB/BCL2/MAP3K5/CASP8/NFKB1/PIK3CA/GADD45A/DDIT3/NOL3/PIK3CD/TRAF1	2.14376805348363
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/1095	103/9376	1.57950082014452	CD247/CD3G/CD3E/CD3D/MAPK1/MAP2K4/TGFBR2/PIK3R1/TGFB1/GNAQ/PPP2R2B/CASP8/NFKB1/PIK3CA/GNAI3/IRAK4/IFNGR1/PIK3CD/PPP2R1A	2.15037322006309
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/1095	83/9376	1.65061341255433	JARID2/UBE2D2/YAF2/KDM2A/MBD5/ASXL1/SFMBT2/AUTS2/LCOR/UBE2D3/PCGF5/ASXL2/PHC3/USP7/FOXK2/UBE2D1	2.16488781088931
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	17/1095	90/9376	1.61737189244039	PRKACB/FOXO3/PIK3R1/CAMK4/IGF1R/CREB1/ADIPOR1/NFKB1/PIK3CA/RPS6KB2/RPTOR/FOXO1/ATG5/ATG13/RPS6KB1/PIK3CD/SESN3	2.1399571324438
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	14/1095	71/9376	1.68839153643321	TH/IRF1/STAT3/CCND1/GSK3B/MAPK1/FOXO3/PIK3R1/SOS1/CCND2/NFKB1/PIK3CA/SOS2/PIK3CD	2.11718014867601
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	19/1095	105/9376	1.54941509023701	IRF1/PPP3CA/NFATC3/CBLB/MAPK1/CYLD/PIK3R1/RELB/NFATC2/PPP3CC/CASP8/RRAS2/NFKB1/PIK3CA/PPP3CB/RRAS/PIK3CD/PYCARD/SYK	2.05865346717401
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1095	78/9376	1.64664559185107	SEPTIN6/CLTB/CD2AP/ACTB/PIK3R1/ACTR2/ELMO1/SEPTIN1/ACTR3/ACTG1/CAV2/ARPC4/PIK3CA/PIK3CD/MAD2L2	2.085307749844
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/1095	333/9376	1.28566923087471	THBS1/PPP2R5C/IRF1/PKM/WNT5A/CCND3/LAMB3/JAK1/ITGA4/CCND1/ATM/ITGA6/PRKACB/ITGB6/LLGL2/TCF7/GSK3B/CDK6/ITGB4/WNT2/MAPK1/ATP6V1D/PIK3R1/SOS1/MAML2/CREB1/CCND2/RBL2/UBR4/PPP2R2B/DLG1/PATJ/TRAF3/RB1/CASP8/NFKB1/CDKN1B/PIK3CA/ATP6V1G1/CSNK1A1/RPS6KB2/SOS2/FOXO1/ITGAV/LAMC2/PSEN1/RPS6KB1/PIK3CD/ATR/PPP2R1A	1.93010360684522
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	28/1095	170/9376	1.41030351866774	TUBA4A/EZR/MYH14/RAB8B/RAP1A/YBX3/CCND1/PRKACB/LLGL2/ROCK1/ACTB/ACTR2/ACTR3/ACTG1/MYL12A/PPP2R2B/DLG1/WHAMM/ARPC4/MAP3K5/PATJ/MAP3K1/RAB8A/MYL12B/ARHGEF18/PRKCE/TIAM1/PPP2R1A	1.96311400913031
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	29/1095	178/9376	1.39502334410754	RAC2/PPP3CA/WNT5A/PRKCB/CCND3/RBX1/CCND1/PRKACB/NFATC3/PRKCA/TCF7/GSK3B/WNT2/CAMK2D/TLE4/NFATC2/TBL1X/CCND2/PPP3CC/FBXW11/DAAM1/CCDC88C/CSNK1A1/PPP3CB/LEF1/CTBP2/CTNNBIP1/PSEN1/SENP2	1.93480573153677
NA	NA	hsa04519	Cadherin signaling	59/1095	404/9376	1.25047244450472	KRT6A/KRT24/KRT5/KRT17/KRT14/KRT19/RAC2/DSG1/KRT18/PPP1CB/KRT10/WNT5A/DSC2/DSC3/KRT16/DSG2/BRK1/PKP3/TCF7/GSK3B/EVL/ERBIN/JUP/CYFIP2/KRT8/PPP1CA/WNT2/MAPK1/YWHAZ/ROCK1/ACTB/TAOK3/ACTR2/YWHAQ/IGF1R/GABRP/ACTR3/ACTG1/DSP/ARPC4/PSENEN/VAV3/RRAS2/NFKB1/DAAM1/CSNK1A1/SHOC2/TAOK1/TMC6/PKP1/LEF1/TMC8/RERE/RRAS/PSEN1/MYO1D/MYO1F/NCKAP1/CIB2	1.87135986047916
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1095	60/9376	1.71251141552511	RAC2/PPP3CA/PRKCB/PRKCA/MAPK1/PIK3R1/NFATC2/PPP3CC/MAPKAPK3/PIK3CA/PPP3CB/PIK3CD	2.01327925024888
NA	NA	hsa04517	IgSF CAM signaling	45/1095	299/9376	1.28867915883997	MBP/TUBA4A/CD48/LMO7/FYN/CD96/EZR/MYH14/PRKCB/RAP1A/ITGA4/CD2/PRKCA/GSK3B/CD2AP/LCK/MAPK1/RAP1B/ACTB/PIK3R1/SLITRK6/ACTR2/ICAM3/ACTR3/LYN/ACTG1/ARF6/DYNLL1/MYL12A/PRKCQ/ARPC4/ITGAL/VAV3/PIK3CA/CASK/FOXO1/MYL12B/ANK3/PTPN6/DYNLL2/SH2D1A/SLIT2/PIK3CD/NCK1/PALS2	1.84472300210869
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1095	122/9376	1.47388277565686	PRKCB/CCND1/NCOA1/PRKACB/PRKCA/GSK3B/KAT2B/MAPK1/ACTB/PIK3R1/NCOR1/ACTG1/NCOA2/PIK3CA/FOXO1/MED13L/ITGAV/NCOA3/PLCD1/PIK3CD/MED13	1.91574365922058
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1095	69/9376	1.6132353914367	RAC2/FYN/PRKCA/MAPK1/MAP2K4/PIK3R1/SOS1/LYN/VAV3/PIK3CA/SOS2/PIK3CD/SYK	1.85908054072715
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1095	184/9376	1.34953345245186	RHOD/RAC2/FYN/PPP3CA/WNT5A/SSH2/NFATC3/PRKCA/GSK3B/MAPK1/ROCK1/CAMK2D/PIK3R1/NFATC2/PPP3CC/SEMA4D/MYL12A/CFL1/PIK3CA/GNAI3/PPP3CB/MYL12B/EPHA4/NGEF/RRAS/SLIT2/PIK3CD/SEMA3C/NCK1	1.74118114578446
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1095	133/9376	1.41636282487039	PPP2R5C/TH/GNG2/PPP3CA/PPP1CB/PRKCB/PRKACB/COMT/PRKCA/GSK3B/PPP1CA/CAMK2D/GNAQ/CREB1/GNB1/PPP3CC/PPP2R2B/GNB5/GNAI3/PPP3CB/KIF5B/PPP2R1A	1.75850090369151
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1095	37/9376	1.85136369245958	BRAF/CCND1/TCF7/CCDC6/MAPK1/TFG/GADD45A/LEF1	1.88676193108884
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1095	149/9376	1.37920382458398	GNG2/NDUFB2/PRKCB/NDUFA4/NDUFS4/PRKACB/NDUFB4/PRKCA/NDUFB1/NDUFB11/NDUFA2/NDUFB6/NDUFS5/MAPK1/NDUFB9/NDUFB7/NDUFA1/GNAQ/GNB1/GABRP/NDUFA4L2/GNB5/GNAI3/NDUFA5	1.69662900887734
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1095	44/9376	1.75143212951432	APEX1/POLE4/RFC1/POLE3/POLB/APTX/MPG/HMGB1/PNKP	1.81668671040098
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1095	44/9376	1.75143212951432	ARHGDIB/VAMP2/RAB11A/PRKACB/CREB1/DYNLL1/DCTN6/DYNLL2/RAB5A	1.81668671040098
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1095	99/9376	1.47033808403671	BRAF/CCND1/PRKACB/MAPK1/PIK3R1/NCOR1/SOS1/IGF1R/BCL2/RB1/CDKN1B/PIK3CA/RPS6KB2/SOS2/NCOA3/RPS6KB1/PIK3CD	1.71070557288764
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1095	86/9376	1.49346925772539	DSC2/ITGA4/DSG2/ITGA6/ITGB6/TCF7/JUP/ITGB4/ACTB/ACTG1/DSP/SNTB1/LEF1/SGCE/ITGAV	1.67167857412396
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1095	32/9376	1.87305936073059	ATG3/RPTOR/ATG5/BECN1/ATG13/ATG7/GABARAPL2	1.79888604546139
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1095	32/9376	1.87305936073059	BIRC6/PMAIP1/BIRC2/BCL2/CASP8/BECN1/BOK	1.79888604546139
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/1095	144/9376	1.36763064434297	PRKCB/RORA/PSMD8/ATXN1/VDAC2/PRKCA/SEM1/NRBF2/ERN1/PIK3R1/VDAC1/GNAQ/MAP3K5/PIK3CA/MCU/PSMB7/AMBRA1/BECN1/ATG13/PSMD12/ATXN10/PIK3CD/ATG14	1.61657686408548
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/1095	115/9376	1.41468334325988	FYN/GNG2/PRKCB/PRKACB/PRKCA/PIK3R5/MAPK1/CAMK2D/PIK3R1/CAMK4/GNAQ/CREB1/GNB1/BCL2/GNB5/PIK3CA/GNAI3/KCNQ5/PIK3CD	1.62700120575746
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1095	20/9376	2.14063926940639	CYB5R1/CYB5R3/GMDS/UAP1/CYB5R4	1.85681876277954
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/1095	227/9376	1.28249753585581	RAC2/GNG2/PPP3CA/PRKCB/AKAP13/JAK1/STAT3/CCND1/PRKACB/NFATC3/PRKCA/GSK3B/CDK6/MAPK1/ROCK1/PIK3R1/GNAQ/SOS1/NFATC2/CREB1/GNB1/PPP3CC/RB1/CASP8/GNB5/NFKB1/PIK3CA/RPS6KB2/GNAI3/SOS2/PPP3CB/ITGAV/RPS6KB1/PIK3CD	1.5667225135521
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1095	73/9376	1.52483893163195	KAT2B/VPS4B/SERINC5/CHMP4B/PIN1/MDFIC/APOBEC3C/XPO1/NUP153/CCNT1/APOBEC3G/TNPO3/MAP1B	1.63691929457431
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	22/1095	139/9376	1.35522486120692	KRT24/KRT17/KRT14/KRT19/KRT18/KRT10/KRT16/NCOA1/PRKACB/MAPK1/PIK3R1/GNAQ/SOS1/CREB1/NCOA2/BCL2/FKBP5/PIK3CA/GNAI3/SOS2/NCOA3/PIK3CD	1.53425160763844
NA	NA	hsa04518	Integrin signaling	24/1095	154/9376	1.33442447962996	THBS1/RAC2/CCND3/LAMB3/ITGA4/CCND1/ITGA6/ITGB6/GSK3B/ITGB4/FLNB/ACTB/PIK3R1/TGFB1/IGF1R/CCND2/ICAM3/ACTG1/ITGAL/PIK3CA/ITGAV/VEGFB/LAMC2/PIK3CD	1.52158832363086
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	24/1095	154/9376	1.33442447962996	PPP3CA/PPP1CB/CAMK1D/PRKCB/CCND1/PPP1R12A/PRKACB/NFATC3/PRKCA/PIK3R5/PPP1CA/MAPK1/ROCK1/CAMK2D/ACTB/CAMK4/GNAQ/NFATC2/PPP3CC/ACTG1/CD38/GNAI3/PPP3CB/GUCY1A1	1.52158832363086
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1095	27/9376	1.90279046169457	HACD4/TECR/HACD2/ELOVL1/SCP2/ELOVL5	1.70819548491274
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	30/1095	200/9376	1.28438356164384	GAPDH/TUBA4A/FYN/EZR/MYH14/BRK1/TMED10/CYFIP2/MAPK1/ROCK1/ACTB/ACTR2/WIPF1/ACTR3/ACTG1/RPS3/ARF6/TAB2/ARPC4/CASP8/NFKB1/IRAK4/PTPN6/SEC24B/MYO1D/MYO1F/PYCARD/NCKAP1/NCK1/TAB3	1.47823707324464
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1095	21/9376	2.03870406610133	CHST11/CSGALNACT2/CHST12/UST/B3GAT3	1.73272997571068
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1095	119/9376	1.36713096197383	IRF1/RPS6KA5/MAPK1/MAP2K4/CYLD/PIK3R1/CREB1/BIRC2/TAB2/MAP3K5/TRAF3/CASP8/NFKB1/PIK3CA/DNM1L/PIK3CD/TNFAIP3/TRAF1/TAB3	1.46558383620081
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/1095	157/9376	1.30892592269435	PPP1CB/WNT5A/CCND3/CCND1/LLGL2/TCF7/GSK3B/AREG/PPP1CA/WNT2/YWHAZ/TGFBR2/ACTB/TGFB1/YWHAQ/CCND2/ACTG1/BIRC2/PPP2R2B/DLG1/FBXW11/PATJ/LEF1/PPP2R1A	1.41942868208905
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1095	69/9376	1.48914036132619	TH/PPP3CA/PPP1CB/PRKCB/PRKACB/PRKCA/PPP1CA/CAMK2D/CAMK4/CREB1/PPP3CC/PPP3CB	1.48287483097691
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1095	150/9376	1.31292541856925	BRAF/WNT5A/CCND1/TCF7/GSK3B/JUP/WNT2/MAPK1/TGFBR2/PIK3R1/TGFB1/SOS1/BCL2/RB1/CDKN1B/PIK3CA/CSNK1A1/GADD45A/RPS6KB2/SOS2/LEF1/RPS6KB1/PIK3CD	1.40485354490474
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1095	91/9376	1.41141050730092	GNG2/PDE3B/PRKCB/PDE7A/PDE4D/PRKACB/PRKCA/GNB1/GABRP/PDE4B/GNB5/GNAI3/GRK6/PDE4A/GRK5	1.43402402325493
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/1095	70/9376	1.46786692759296	RAC2/FYN/CD55/CCND1/PRF1/ACTB/ACTG1/EIF4G3/ITGAL/CASP8/SNTB1/SGCE	1.42870034105004
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/1095	122/9376	1.33351298749906	PPP2R5C/RAB2A/RAB10/CCND1/FOXO3/PIK3R1/IGF1R/CREB1/ADIPOR1/PPP2R2B/PIK3CA/RAB8A/RPS6KB2/RPTOR/FOXO1/RPS6KB1/PIK3CD/TBC1D1/PPP2R1A	1.34827730377711
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/1095	238/9376	1.2232224396608	STK4/RAC2/REL/RALGAPA1/GNG2/RASA2/PRKCB/RAP1A/IGF2/PRKACB/PRKCA/ETS1/MAPK1/RAP1B/PIK3R1/SOS1/IGF1R/GNB1/PLAAT2/RASGRP1/ARF6/GNB5/RRAS2/NFKB1/PIK3CA/SHOC2/SOS2/RASSF5/VEGFB/FLT3LG/RAB5A/RRAS/PIK3CD/TIAM1	1.26838780401986
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	31/1095	216/9376	1.22888550651108	PPP3CA/MIB2/STAT3/RAP1A/NFATC3/PRKCA/GSK3B/MAPK1/MAP2K4/RAP1B/CAMK2D/ERN1/PIK3R1/NFE2L2/NFATC2/PPP3CC/LYN/BCL2/TAB2/MAP3K5/ATF6/TRAF3/CASP8/VAV3/NFKB1/PIK3CA/PPP3CB/IRAK4/DDIT3/PIK3CD/PYCARD	1.23751005788689
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1095	109/9376	1.33544468183151	PPP1CB/PRKCB/STAT3/GSK3B/PPP1CA/PIK3R1/CREB1/RPS6KA3/PRKCQ/NFKB1/PIK3CA/PTPN1/RPS6KB2/FOXO1/RPS6KB1/PRKCE/PIK3CD	1.28090194128419
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/1095	201/9376	1.23539380721961	H3-3B/REL/BCL11B/KDM6A/H3-3A/ATM/JUP/JMJD1C/SUPT3H/TGFBR2/SPINT1/NCOR1/IGF1R/CCND2/BIRC2/GZMB/ETV6/IGFBP3/NFKB1/CDKN1B/ATF1/KLF3/GADD45A/FOXO1/DDIT3/CCNT1/PBX3/KMT2A/TRAF1	1.22670837662197
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1095	51/9376	1.51103948428687	PRKACB/PRKCA/KDELR1/ATP6V1D/ACTB/SEC61G/SEC61B/ACTG1/ATP6V1G1	1.33065793918854
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1095	44/9376	1.55682855956829	CCNH/TAF7/GTF2F2/GTF2H5/TAF11/TAF4B/TAF1/MNAT1	1.34620680219417
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/1095	140/9376	1.28438356164384	GNG2/PDE3B/CCND1/PRKACB/PIK3R5/MAPK1/CAMK4/GNAQ/GNB1/GNB5/RRAS2/RPS6KB2/NRF1/MAP1LC3B/GNAI3/HDAC4/MEF2A/BECN1/RRAS/RPS6KB1/PRKCE	1.232758058664
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1095	148/9376	1.27281253856596	BRAF/WNT5A/CCND1/NCOA1/TCF7/GSK3B/CDK6/WNT2/MAPK1/PIK3R1/SOS1/IGF1R/RB1/PIK3CA/CSNK1A1/GADD45A/RPS6KB2/SOS2/LEF1/NCOA3/RPS6KB1/PIK3CD	1.21644561446617
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1095	187/9376	1.23630503259834	TXN/JAK1/VDAC2/NEK7/ERBIN/MAPK1/GBP2/VDAC1/RIPK2/BIRC2/BCL2/TAB2/TRAF3/CASP8/NFKB1/MCU/MAP1LC3B/DNM1L/TRPM7/ATG5/IRAK4/PKN2/GABARAPL2/PYCARD/BRCC3/TNFAIP3/TAB3	1.18689132035594
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	28/1095	195/9376	1.2294953752488	H3-3B/RAC2/H2AZ1/PRKCB/H2AJ/H3-3A/VDAC2/H4C3/PRKCA/H2AZ2/MACROH2A1/MAPK1/H2AX/SELPLG/ACTB/PIK3R1/VDAC1/ACTG1/H2AC6/ITGAL/NFKB1/PIK3CA/HDAC4/ATG7/PIK3CD/H2AC20/SYK/HMGB1	1.17759934541871
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1095	38/9376	1.57731314587839	SFN/PRKCB/PRKCA/MAPK1/PIK3R1/PIK3CA/PIK3CD	1.29666448476842
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1095	38/9376	1.57731314587839	CD3E/CD3D/IL2RG/IL7R/PTPRC/LCK/ICOS	1.29666448476842
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/1095	142/9376	1.26629365232491	FYN/PPP3CA/JAK1/LCK/MAPK1/CYLD/TGFBR2/PIK3R1/TGFB1/RELB/CAMK4/NFATC2/CREB1/PPP3CC/TAB2/NFKB1/PIK3CA/PPP3CB/IFNGR1/PIK3CD/SYK	1.16268309167364
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/1095	142/9376	1.26629365232491	RAC2/TXN/GSTP1/MAP2K4/SUMO1/SUMO2/ACTB/PIK3R1/NFE2L2/ACTG1/CAV2/BCL2/MAP3K5/GSTO2/NFKB1/MGST3/PIK3CA/ITGAV/MEF2A/ACVR2A/PIK3CD	1.16268309167364
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1095	158/9376	1.246448182186	BRAF/WNT5A/PRKCB/PRKCA/GSK3B/WNT2/LAMTOR4/MAPK1/ATP6V1D/PIK3R1/SOS1/IGF1R/RICTOR/RPS6KA3/CLIP1/PIK3CA/ATP6V1G1/RPS6KB2/RPTOR/SOS2/RPS6KB1/PIK3CD/FNIP1	1.13602297895524
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1095	60/9376	1.42709284627093	BRAF/PRKCB/PRKCA/MAPK1/GNAQ/IGF1R/LYN/GNAI3/GUCY1A1/PPP2R1A	1.20679773908364
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1095	53/9376	1.45401912638925	PRKCB/AP2S1/ATP2B1/CLTB/ATP2B4/RAB11A/PRKACB/PRKCA/GNAQ	1.20527333041202
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1095	33/9376	1.55682855956829	STX8/VAMP2/VTI1A/VAMP8/VTI1B/STX5	1.16516277980939
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/1095	138/9376	1.24095030110516	PPP2R5C/PPP3CA/PPP1CB/RBX1/ANAPC16/PRKACB/PPP1CA/MAPK1/YWHAZ/CAMK2D/YWHAQ/IGF1R/CDC27/PPP3CC/RPS6KA3/FBXW11/PPP3CB/CDC26/MAD2L2/PPP2R1A	1.0368820185375
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/1095	115/9376	1.26576930712726	BRAF/PRKCB/AKAP13/OXSR1/PDE4D/PRKACB/PRKCA/MAPK1/GNAQ/CREB1/STK39/BCL2/PDE4B/PTHLH/GNAI3/MEF2A/PDE4A	1.04274017796367
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1095	100/9376	1.28438356164384	CD9/CD59/CD7/CD3G/CD37/CD3E/CD55/ITGA4/CD3D/CD2/IL7R/ITGA6/CD38/FLT3LG/CD44	1.03962191208616
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	48/1095	362/9376	1.13536668432604	THBS1/PPP2R5C/GNG2/CCND3/LAMB3/JAK1/ITGA4/CCND1/IL2RG/IL7R/IGF2/ITGA6/PRKCA/ITGB6/GSK3B/CDK6/ITGB4/PIK3R5/AREG/MAPK1/YWHAZ/FOXO3/PIK3R1/YWHAQ/SOS1/IGF1R/CREB1/CCND2/GNB1/RBL2/PPP2R2B/BCL2/GNB5/NFKB1/CDKN1B/PIK3CA/RPS6KB2/RPTOR/SOS2/PKN2/ITGAV/VEGFB/FLT3LG/LAMC2/RPS6KB1/PIK3CD/SYK/PPP2R1A	0.955121464924268
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1095	41/9376	1.4618999888629	ATM/SEM1/RPA2/BABAM2/RAD51B/RPA3/BRCC3	1.07778968897133
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1095	34/9376	1.51103948428687	CRY1/RORA/RBX1/NR1D2/CREB1/FBXW11	1.08548865481301
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/1095	156/9376	1.20754010069079	BRAF/JAK1/STAT3/PIAS1/CCND1/GSK3B/CDK6/MAPK1/YWHAZ/PIK3R1/YWHAQ/SOS1/PPP2R2B/TRAF3/RB1/CASP8/NFKB1/EIF3E/PIK3CA/SOS2/PIK3CD/PPP2R1A	0.950495723509573
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/1095	212/9376	1.17129318514689	THBS1/RAC2/SKAP1/SIPA1L1/BRAF/PRKCB/RAP1A/APBB1IP/FYB1/PRKCA/EVL/MAPK1/RAP1B/ACTB/PIK3R1/GNAQ/IGF1R/ACTG1/ITGAL/VAV3/PIK3CA/GNAI3/RASSF5/VEGFB/RRAS/PIK3CD/TIAM1/PFN2/PFN1	0.917311378675327
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/1095	157/9376	1.19984876246983	THBS1/ATP11B/CD47/NFATC3/MAPK1/CAMK2D/TGFB1/ELMO1/NFATC2/CREB1/RAB7A/DUSP2/CX3CR1/ATP8A1/ODC1/ITGAV/PTPN6/RAB5A/VPS41/GAS6/ATP11C/VPS8	0.918249472415851
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1095	42/9376	1.42709284627093	VDAC2/ACSL3/PCBP2/MAP1LC3B/ATG5/ATG7/SLC39A8	1.00870540868373
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/1095	166/9376	1.18637839027342	PPP3CA/PPP1CB/PDE3B/ATP2B1/VDAC2/ATP2B4/PPP1R12A/NFATC3/PIK3R5/PPP1CA/MAPK1/ROCK1/VDAC1/GNAQ/NFATC2/CREB1/PPP3CC/GNAI3/PPP3CB/GUCY1A1/MEF2A/KCNMA1/PRKCE	0.880990227267883
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1095	28/9376	1.52902804957599	HACD4/TECR/HACD2/ELOVL1/ELOVL5	1.01941182878436
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1095	21/9376	1.63096325288106	DPYD/PPCS/BCAT1/PANK2	1.05255094065674
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1095	191/9376	1.1655836859595	H3-3B/TH/GNG2/PPP1CB/BRAF/H2AZ1/H2AJ/H3-3A/H4C3/PRKACB/H2AZ2/MACROH2A1/PPP1CA/MAPK1/H2AX/CAMK4/SOS1/CREB1/GNB1/H2AC6/GNB5/GNAI3/SOS2/HDAC4/H2AC20/PKIA	0.840709499498058
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/1095	112/9376	1.2232224396608	LAMB3/JAK1/STAT3/ITGA6/PIK3R5/MAPK1/TGFB1/BIRC2/BCL2/TAB2/CASP8/NFKB1/GNAI3/IRAK4/IFNGR1/LAMC2	0.864169419821155
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1095	36/9376	1.42709284627093	C1GALT1/B3GNT3/GALNT1/GALNT11/GALNT3/GALNT10	0.933579732546267
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	6/1095	36/9376	1.42709284627093	RPA2/POLE4/RFC1/POLE3/RPA3/RNASEH2B	0.933579732546267
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	17/1095	122/9376	1.19314319934127	PRKCB/STAT3/PRKACB/PRKCA/GSK3B/MAPK1/MAP2K4/PIK3R1/GNAQ/SOS1/CREB1/IGFBP3/PIK3CA/MAP3K1/GNAI3/SOS2/PIK3CD	0.780810948333639
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/1095	130/9376	1.18558482613277	GNG2/PRKACB/PRKCA/MAPK1/MAP2K4/TGFBR2/PIK3R1/TGFB1/SOS1/CREB1/GNB1/GNB5/NFKB1/PIK3CA/GNAI3/SOS2/VEGFB/PIK3CD	0.774798018612989
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1095	83/9376	1.23796005941575	SOD1/ACSL3/GSTK1/PRDX5/CROT/PMVK/SCP2/PEX2/PEX13/ABCD3/HACL1/PEX16	0.791801739968937
Genetic Information Processing	Transcription	hsa03040	Spliceosome	32/1095	243/9376	1.12757953285604	SYF2/THOC7/BCAS2/DDX46/SF1/TXNL4A/SRSF10/SNRPD2/LSM8/SNRPB/TRA2A/LSM5/CDC40/LSM4/U2AF1/PRPF40A/CCDC12/U2SURP/PQBP1/HNRNPC/CTNNBL1/SF3B6/ZMAT2/LSM6/PRPF4/DDX42/SNRNP200/PRPF18/SMNDC1/SNIP1/ALYREF/SART1	0.732704267562515
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1095	107/9376	1.20035846882601	PPP3CA/PKM/PDE3B/PRKACB/SIK2/SIK1/CAMK2D/GNAQ/CREB1/PPP3CC/PPP4R3B/PGAM1/FOXO1/PPP3CB/PPP4R3A	0.757939354106783
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1095	23/9376	1.48914036132619	PMVK/IDI1/FNTA/MVD	0.854030254981137
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1095	69/9376	1.24095030110516	PPP3CA/PDE3B/PRKACB/GNAQ/CREB1/PPP3CC/GNAI3/PPP3CB/GUCY1A1/KCNMA1	0.730463411476436
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1095	173/9376	1.13837464037797	PRKCB/CCND3/JAK1/RAB11A/PRKCA/CDK6/MAPK1/ACTB/PIK3R1/VDAC1/ACTG1/NUP98/TRAF3/CASP8/NFKB1/PIK3CA/IRAK4/NXT1/XPO1/PRSS3/IFNGR1/PIK3CD/PYCARD	0.66798414016584
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/1095	87/9376	1.18104235553456	COX7A1/COX7A2/COX7C/COX7A2L/UQCR11/COX6B1/COX6A1/UQCRH/COX8A/UQCR10/COX6C/COX4I1	0.616888454092934
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1095	144/9376	1.12978183663115	WNT5A/JARID2/HAND1/JAK1/STAT3/TCF7/GSK3B/WNT2/MAPK1/PIK3R1/KAT6A/IGF1R/PIK3CA/ID4/REST/PCGF5/ACVR2A/RIF1/PIK3CD	0.570687775093936
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1095	128/9376	1.13721461187215	PDE3B/ADK/PDE7A/PDE4D/HDDC2/NME3/ITPA/PGM1/GUK1/ADSS2/FHIT/RRM1/PDE4B/DGUOK/NT5C2/GUCY1A1/PDE4A	0.568372086820253
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1095	56/9376	1.2232224396608	CCND1/PRKACB/GSK3B/CCND2/FBXW11/BCL2/CSNK1A1/SPOP	0.609221488144064
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1095	97/9376	1.14755919597044	GNG2/PRKCB/PRKACB/PRKCA/RPS6KA5/MAPK1/CAMK2D/GNAQ/CREB1/GNB1/GNB5/GNAI3/GUCY1A1	0.531193638558392
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1095	89/9376	1.1545020778821	SLC38A1/GNG2/PRKCB/PRKACB/PRKCA/TRAK2/GNB1/GABRP/GNB5/GNAI3/PLCL1/GABARAPL2	0.532528567657817
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1095	41/9376	1.25305713331106	THBS1/BRAF/CCND1/RPS6KA5/MAPK1/RB1	0.59047927165951
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/1095	138/9376	1.11685527099464	PPP1CB/BRAF/PDE3B/PRKACB/GSK3B/PPP1CA/CBLB/MAPK1/PIK3R1/SOS1/PIK3CA/PTPN1/RPS6KB2/RPTOR/SOS2/FOXO1/RPS6KB1/PIK3CD	0.502863572736479
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1095	73/9376	1.17295302433227	BRAF/CCND1/CDK6/MAPK1/PIK3R1/IGF1R/RB1/PIK3CA/GADD45A/PIK3CD	0.539422907717918
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1095	57/9376	1.20176239685973	HACD4/TECR/HACD2/ACSL3/ELOVL1/SCP2/ELOVL5/ACADM	0.555577060902342
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/1095	66/9376	1.16762141967621	STAT4/RORA/STAT3/IL2RG/TGFB1/IL21R/NFKB1/IFNGR1/TBX21	0.496910240987517
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/1095	34/9376	1.25919957023905	POLR2L/POLR2I/POLR1D/POLR2K/POLR1F	0.550560575998401
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1095	99/9376	1.12437618191043	PPP1CB/PRKCB/PRKCH/PRKACB/PRKCA/PPP1CA/CAMK2D/PIK3R1/GNAQ/PRKCQ/PIK3CA/PRKCE/PIK3CD	0.452378905196306
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	13/1095	99/9376	1.12437618191043	RAC2/PRKCB/PRKCA/MAPK1/PIK3R1/SOS1/GPCPD1/PIK3CA/RPS6KB2/SOS2/CHPT1/RPS6KB1/PIK3CD	0.452378905196306
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/1095	116/9376	1.10722720831365	GAPDH/PKM/TPI1/OGDH/ESD/TALDO1/SUCLG2/PGLS/ENO1/MDH2/PGK1/PGP/ME2/PGAM1/SUCLA2	0.422551653905773
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/1095	59/9376	1.1610246884916	GSTK1/GSTP1/GGCT/SMS/RRM1/GSTO2/MGST3/ODC1	0.451161187626304
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/1095	134/9376	1.08629455462414	PPP1CB/BRAF/MYH14/PRKCB/PRKCH/PPP1R12A/PRKACB/PRKCA/PPP1CA/MAPK1/ROCK1/GNAQ/PRKCQ/AVPR1A/GUCY1A1/KCNMA1/PRKCE	0.365850888593204
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1095	101/9376	1.10211130702111	WNT5A/PRKCB/PRKACB/PRKCA/TCF7/GSK3B/WNT2/MAPK1/CAMK2D/GNAQ/CREB1/GNAI3/LEF1	0.37517066095456
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/1095	226/9376	1.06084777952883	RAC2/PPP1CB/BRAF/PDE3B/ATP2B1/PDE4D/RAP1A/ATP2B4/PPP1R12A/PRKACB/PPP1CA/MAPK1/RAP1B/ROCK1/CAMK2D/PIK3R1/CAMK4/CREB1/PDE4B/VAV3/RRAS2/NFKB1/PIK3CA/GNAI3/PDE4A/RRAS/PIK3CD/TIAM1	0.336697361033655
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1095	93/9376	1.10484607453233	PRKCB/PRKACB/PRKCA/MAP3K2/MAPK1/MAP2K4/CAMK2D/GNAQ/SOS1/MAP3K1/SOS2/MAP3K4	0.369488375444138
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1095	85/9376	1.10809562181037	ADK/CMPK1/HDDC2/NME3/ITPA/GUK1/ADSS2/RRM1/DGUOK/DUT/NT5C2	0.364030391209604
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/1095	110/9376	1.0897799916978	THBS1/RBX1/EMP3/MAPK1/TGFBR2/ROCK1/TGFB1/NCOR1/LEMD3/RPS6KB2/ID4/ACVR2A/RPS6KB1/PPP2R1A	0.344414209638964
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1095	110/9376	1.0897799916978	BRAF/PDE3B/ANAPC16/PRKACB/MAPK1/PIK3R1/IGF1R/CDC27/RPS6KA3/PIK3CA/GNAI3/CDC26/PIK3CD/MAD2L2	0.344414209638964
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1095	44/9376	1.16762141967621	DAD1/OSTC/KRTCAP2/MAN1A2/MGAT4A/ALG13	0.405246985780531
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1095	102/9376	1.09130629420718	PRKCB/ATP2B1/RAP1A/ATP2B4/RAB11A/PRKCA/RAP1B/GNAQ/CD38/RAB27B/RAB8A/KCNMA1/PRSS3	0.337146427603137
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	18/1095	144/9376	1.0703196347032	CCND1/TCF7/GSK3B/MAP2K4/FOXO3/TRA2A/ADIPOR1/TAB2/MAP3K5/TRAF3/CASP8/NFKB1/FOXO1/LEF1/IRAK4/IL17RC/ACADM/TAB3	0.30921550284605
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/1095	103/9376	1.08071108746731	PRKCB/LAMB3/PRKACB/PRKCA/PIK3R1/TGFB1/GNAQ/RAB7A/NFKB1/PIK3CA/RAB5A/LAMC2/PIK3CD	0.299497351890854
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1095	78/9376	1.09776372790071	PIP4K2A/TPI1/ITPKB/INPP4B/INPP4A/PIK3CA/MTMR3/CDIPT/PLCD1/PIK3CD	0.315269232504026
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/1095	78/9376	1.09776372790071	PRKCB/JAK1/ITGA4/MAPK1/TGFB1/TAB2/NFKB1/IRAK4/PTPN6/IFNGR1	0.315269232504026
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1095	62/9376	1.10484607453233	ATXN1/KAT2B/CIR1/TLE4/MAML2/PSENEN/CTBP2/PSEN1	0.30118352258485
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1095	155/9376	1.04960377080572	BRAF/WNT5A/RAP1A/CCND1/PRKACB/TCF7/GSK3B/CDK6/WNT2/MAPK1/RAP1B/CAMK2D/GNAQ/CREB1/RB1/CDKN1B/GNAI3/LEF1/KMT2A	0.226434624196903
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/1095	46/9376	1.11685527099464	PSMD8/SEM1/PSME4/PSMB7/PSMD12/PSMB10	0.28889345733131
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1095	63/9376	1.08730883525404	KMT2E/SMYD3/ASH1L/NSD3/KMT2C/NSD1/CAMKMT/KMT2A	0.252833707584069
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1095	13/9376	1.31731647348086	XRCC5/XRCC4	0.416301608591617
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	28/1095	233/9376	1.02897681619535	THBS1/TMOD3/MYH14/DIAPH1/DSC2/PLEC/ITGA4/PDLIM4/DSG2/ITGA6/ITGB6/PDLIM2/JUP/ITGB4/NEBL/SYNE1/ACTB/DIAPH2/ACTG1/DSP/ENO1/SUN1/DAAM1/SYNE2/SNTB1/SGCE/ITGAV/ANK3	0.162867928284928
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	30/1095	250/9376	1.02750684931507	CTSW/AP2S1/CLTB/CD164/LAMTOR4/ATP6V1D/AP3S1/IGF2R/BORCS7/AP3B1/RAB7A/VAMP8/VPS13A/SUMF1/LAMP1/ATP6V1G1/RPTOR/OSBPL1A/DMXL1/VPS41/AP1M2/NCOA7/SLC15A4/OSTM1/BLOC1S4/OSBPL3/LITAF/WDR7/OSBP/OSBPL5	0.160295719768692
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/1095	89/9376	1.05829357139192	TUBA4A/PRKCB/PRKACB/PRKCA/MAP3K2/MAPK1/GNAQ/SOS1/GNAI3/SOS2/GUCY1A1	0.200922812835496
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1095	30/9376	1.14167427701674	OGDH/SUCLG2/MDH2/SUCLA2	0.282611642769148
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1095	30/9376	1.14167427701674	PIGT/PIGK/PIGP/PGAP2	0.282611642769148
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1095	47/9376	1.09309239288837	PKM/MAPK1/PIK3R1/PIK3CA/PRKCE/PIK3CD	0.232646691976948
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1095	98/9376	1.04847637685211	PRKCB/PIP4K2A/PRKCA/ITPKB/PIK3R1/INPP4B/INPP4A/PIK3CA/MTMR3/CDIPT/PLCD1/PIK3CD	0.175415236052802
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1095	98/9376	1.04847637685211	CAMK1D/PRKCB/ATP2B1/ATP2B4/PRKACB/PRKCA/CAMK2D/CAMK4/GNAQ/CREB1/ATF1/PRKCE	0.175415236052802
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1095	56/9376	1.0703196347032	DAD1/OSTC/KRTCAP2/MAN1A2/MGAT4A/DPM1/ALG13	0.191917230923232
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1095	82/9376	1.04421427775922	DPYD/CMPK1/GSTP1/NME3/ITPA/RRM1/GSTO2/MGST3/DUT/TPMT	0.14622426019942
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1095	65/9376	1.05385317878469	PRKCB/PRKCA/MAPK1/PIK3R1/GNAQ/KCNN4/PIK3CA/PIK3CD	0.158424069103484
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1095	31/9376	1.10484607453233	TALDO1/PGM1/PGLS/DERA	0.212615378801642
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1095	14/9376	1.2232224396608	B4GALT4/B3GNT2	0.303926700474838
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/1095	168/9376	1.01935203305066	STAT4/CCND3/JAK1/STAT3/PIAS1/CCND1/IL2RG/IL7R/PTPN2/PIK3R1/SOS1/CCND2/IL21R/BCL2/STAM/PIK3CA/SOS2/PTPN6/IFNGR1/PIK3CD	0.0920343370023295
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1095	23/9376	1.11685527099464	RPA2/RFC1/RPA3	0.204027197045985
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1095	49/9376	1.04847637685211	TH/PRKACB/CREB1/NFKB1/RGS9/GNAI3	0.123711054869085
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/1095	67/9376	1.02239487494037	GAPDH/PKM/TPI1/PGM1/ENO1/PGK1/PGAM1/BPGM	0.0668937947380386
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1095	93/9376	1.0127755683213	PRKCB/ATP2B1/VAMP2/ATP2B4/PRKACB/PRKCA/GNAQ/KCNN4/CD38/GUCY1A1/KCNMA1	0.0450224198232487
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1095	76/9376	1.0139870223504	EZR/PRKCB/PRKACB/PRKCA/CAMK2D/ACTB/GNAQ/ACTG1/GNAI3	0.0445186407774905
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1095	50/9376	1.02750684931507	THBS1/GYPC/KLRB1/HBA2/TGFB1/ITGAL	0.0709135864635745
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1095	59/9376	1.01589660243015	DPYD/CMPK1/HDDC2/NME3/RRM1/DUT/NT5C2	0.0445393193975022
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1095	59/9376	1.01589660243015	PDE3B/PRKACB/PIK3R1/PLAAT2/PIK3CA/GNAI3/PIK3CD	0.0445393193975022
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1095	52/9376	0.987987355110643	VAPA/VDAC2/TSPO/VDAC1/LRPAP1/OSBPL5	-0.0315856983730002
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1095	71/9376	0.964795163676121	PKM/MAPK1/SLC1A5/PIK3R1/PDK1/PIK3CA/PGAM1/PIK3CD	-0.108274109511132
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1095	89/9376	0.962085064901749	THBS1/LAMB3/CD47/ITGA4/ITGA6/ITGB6/ITGB4/ITGAV/CD44/LAMC2	-0.130682941986825
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1095	116/9376	0.959596913871831	SLC38A1/GNG2/PPP3CA/PRKCB/PRKACB/PRKCA/MAPK1/GNAQ/GNB1/PPP3CC/GNB5/GNAI3/PPP3CB	-0.159216966802087
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1095	17/9376	1.00735965619124	SCP2/CYP7B1	0.0110438009161651
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1095	17/9376	1.00735965619124	TXNRD2/MARS1	0.0110438009161651
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1095	17/9376	1.00735965619124	MYH14/LAMP1	0.0110438009161651
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1095	72/9376	0.951395230847286	RNF125/CYLD/PIN1/TRAF3/CASP8/NFKB1/MAP3K1/ATG5	-0.150543354013823
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1095	54/9376	0.951395230847286	RPA2/REV3L/USP1/ERCC1/RPA3/ATR	-0.13024843714175
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1095	154/9376	0.945217339737888	PPP2R5C/PPP1CB/ATP2B1/ATP2B4/PRKACB/PRKCA/RPS6KA5/PIK3R5/PPP1CA/MAPK1/CAMK2D/GNAQ/CREB1/PPP2R2B/BCL2/GNAI3/PPP2R1A	-0.249254050673865
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/1095	181/9376	0.946138903605035	PPP3CA/CORO1A/JAK1/MAPK1/CAMK2D/TGFB1/HSPA9/CREB1/PPP3CC/RIPK2/RAB7A/BCL2/LAMP1/CASP8/NFKB1/PPP3CB/IRAK4/IFNGR1/RAB5A/SYK	-0.266066327899486
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1095	37/9376	0.925681846229791	PRKCB/PRKCA/HBA2/GNAQ	-0.164701248789856
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1095	28/9376	0.917416829745597	B4GALT4/B3GNT3/B3GNT2	-0.159133831718989
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1095	28/9376	0.917416829745597	TH/PTS/GCH1	-0.159133831718989
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/1095	56/9376	0.917416829745597	CASP8/NFKB1/HBS1L/VCP/BNIP3/PYCARD	-0.225387026297599
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/1095	75/9376	0.913339421613394	GAPDH/PKM/TPI1/BCAT1/TALDO1/ENO1/PGK1/PGAM1	-0.27399251463627
Cellular Processes	Cell motility	hsa04814	Motor proteins	21/1095	194/9376	0.926874735206892	TUBA4A/MYH14/DYNLT1/KLC3/KIF2A/DCTN3/KIF1C/ACTB/ACTG1/DYNLL1/MYL12A/DYNLT3/ACTR10/KIF5B/MYL12B/DCTN6/DYNLL2/KIF13B/MYO1D/MYO1F/KIFAP3	-0.374240666509597
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1095	86/9376	0.896081554635234	PRKCB/VAMP2/PRKACB/PRKCA/CAMK2D/GNAQ/CREB1/KCNN4/KCNMA1	-0.352034571258384
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/1095	49/9376	0.873730314043426	C1GALT1/GALNT1/GALNT11/GALNT3/GALNT10	-0.322238522390639
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1095	105/9376	0.897029789084584	ITGA4/ITGA6/PRKACB/ITGB6/ITGB4/ACTB/TGFB1/ACTG1/SNTB1/SGCE/ITGAV	-0.385828466460972
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1095	20/9376	0.856255707762557	EBP/SC5D	-0.23399781686269
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1095	10/9376	0.856255707762557	ETHE1	-0.165373088595675
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/1095	180/9376	0.903825469304921	PPP1CB/ZC3HAV1/JAK1/SRPK1/PPP1CA/PIK3R1/BIRC2/BCL2/TAB2/TRAF3/CASP8/NFKB1/PIK3CA/SP100/IRAK4/IFNGR1/PIK3CD/SYK/ALYREF	-0.473748832237769
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/1095	217/9376	0.907552132651558	PRKCB/CCND3/STAT3/CCND1/PRKACB/PRKCA/KPNA4/MAPK1/PIK3R1/SOS1/CREB1/RPS6KA3/BCL2/GSTO2/RB1/NFKB1/MGST3/PIK3CA/RPS6KB2/GNAI3/SOS2/RPS6KB1/PIK3CD	-0.501018820126343
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1095	61/9376	0.842218728946778	ATP2B1/ATP2B4/ATOX1/TRPM7/MT1X/MT1E	-0.449552320429319
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1095	99/9376	0.864904755315714	KRT24/KRT17/KRT14/KRT19/DSG1/KRT18/KRT10/KRT16/SELPLG/ITGAL	-0.491366095572195
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/1095	99/9376	0.864904755315714	ITGA4/ITGA6/ITGB6/ITGB4/ACTB/TGFB1/ACTG1/SNTB1/SGCE/ITGAV	-0.491366095572195
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1095	32/9376	0.802739726027397	SUCLG2/SUCLA2/ECHDC1	-0.406442872196297
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/1095	109/9376	0.864111264714507	JAK1/MAPK1/MAP2K4/PIK3R1/TAB2/TRAF3/CASP8/NFKB1/PIK3CA/IRAK4/PIK3CD	-0.518893737934616
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1095	63/9376	0.81548162644053	WNT5A/TCF7/GSK3B/WNT2/GADD45A/LEF1	-0.534338413388281
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/1095	149/9376	0.86200239036499	FYN/PRKCA/PIK3R5/MAPK1/PIK3R1/SOS1/ARF6/RRAS2/PIK3CA/AVPR1A/SOS2/RRAS/PIK3CD/SYK/AGPAT4	-0.617427178956722
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1095	12/9376	0.713546423135464	VKORC1	-0.361048442205467
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/1095	94/9376	0.819819294666278	GSK3B/MAPK1/TAB2/TRAF3/CASP8/NFKB1/IL17RC/TNFAIP3/TAB3	-0.638414486065747
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1095	104/9376	0.823322795925536	PLAAT2/GPCPD1/SGMS2/ETNK2/CDIPT/CHPT1/LPGAT1/MBOAT2/AGPAT4/PCYT2	-0.65881242547321
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1095	24/9376	0.713546423135464	HS2ST1/B3GAT3	-0.510927086049714
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/1095	78/9376	0.7684346095305	IRF1/MAPK1/CFL1/NFKB1/GNAI3/IRAK4/PYCARD	-0.746753877899956
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1095	37/9376	0.694261384672344	GMDS/PGM1/UAP1	-0.677567043759531
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1095	26/9376	0.658658236740429	LMBRD1/BTD	-0.633755296060246
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1095	48/9376	0.713546423135464	CD9/VPS4B/CHMP4B/LAMP1	-0.723488954238952
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1095	48/9376	0.713546423135464	PRKCB/PIK3R1/PIK3CA/PIK3CD	-0.723488954238952
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/1095	254/9376	0.842771365908029	PPP3CA/CAMK1D/PRKCB/ATP2B1/VDAC2/ATP2B4/PRKACB/NFATC3/PRKCA/ITPKB/STIM1/CAMK2D/CAMK4/VDAC1/GNAQ/NFATC2/PPP3CC/CD38/ORAI3/MCU/STIM2/AVPR1A/PPP3CB/VEGFB/PLCD1	-0.923750680581152
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/1095	160/9376	0.802739726027397	ALCAM/CD99/SELL/ITGA4/CD2/ITGA6/PTPRC/SELPLG/SPN/SLITRK6/ICAM3/ITGAL/CD6/ITGAV/ICOS	-0.915123474145391
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1095	28/9376	0.611611219830398	ATP6V1D/ATP6V1G1	-0.748406661970662
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1095	29/9376	0.590521177767281	GNB1/RGS9	-0.80305562515783
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1095	115/9376	0.744570180663093	GNG2/BRAF/PRKCB/PRKACB/PRKCA/MAPK1/GNAQ/GNB1/GNB5/GNAI3	-1.00217341931459
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1095	17/9376	0.503679828095622	CA5B	-0.744771362514227
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/1095	155/9376	0.773392252172632	THBS1/TUBA4A/CORO1A/ATP6V1D/ACTB/SEC61G/SEC61B/ACTG1/RAB7A/LAMP1/ATP6V1G1/ITGAV/RAB5A/STX12	-1.03443426549912
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/1095	31/9376	0.552423037266166	MDH2/PGP	-0.907632888489278
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1095	18/9376	0.475697615423643	ACSL3	-0.80961374098141
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1095	18/9376	0.475697615423643	LMBRD1	-0.80961374098141
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1095	19/9376	0.450660898822398	OGDH	-0.871566047801653
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1095	45/9376	0.570837138508371	PRF1/GZMB/KLRD1	-1.04933848224616
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1095	33/9376	0.518942853189429	OGDH/BCAT1	-1.00661123211702
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1095	143/9376	0.718536258262286	H3-3B/H2AZ1/H2AJ/H3-3A/H4C3/H2AZ2/MACROH2A1/H2AX/SNRPB/SSB/H2AC6/H2AC20	-1.23330463377533
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/1095	70/9376	0.611611219830398	STAT3/ACSL3/ADIPOR1/PRKCQ/NFKB1	-1.18600215138753
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1095	47/9376	0.546546196444185	PKM/MDH2/ME2	-1.13322393042497
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1095	35/9376	0.489288975864318	TPI1/GMDS	-1.10068709387432
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/1095	71/9376	0.602996977297575	MAP2K4/ATP6V1D/LYN/NFKB1/ATP6V1G1	-1.2210012386047
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/1095	48/9376	0.535159817351598	BCAT1/OXCT1/ACADM	-1.17403574189466
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/1095	83/9376	0.618980029707873	POLR2L/POLR1D/POLR2K/CASP8/NFKB1/PYCARD	-1.26782736641163
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1095	37/9376	0.462840923114896	ADSS2/NIT2	-1.19043283872921
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1095	37/9376	0.462840923114896	TH/COMT	-1.19043283872921
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/1095	50/9376	0.513753424657534	SMS/CKB/ODC1	-1.25356009218677
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1095	50/9376	0.513753424657534	ITGA4/TGFB1/ICOS	-1.25356009218677
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1095	23/9376	0.372285090331546	LNPEP	-1.09597891882432
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1095	38/9376	0.450660898822398	PGM1/UAP1	-1.23383385200386
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/1095	38/9376	0.450660898822398	CD38/NT5C2	-1.23383385200386
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1095	51/9376	0.503679828095622	PAFAH1B1/PLAAT2/CHPT1	-1.29233140966708
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/1095	75/9376	0.570837138508371	PRKCB/PRKACB/PRKCA/GNAQ/CREB1	-1.35687314575739
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1095	39/9376	0.439105491160286	PRF1/GZMB	-1.27632453508518
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/1095	323/9376	0.768774474461739	THBS1/EZR/PRKCB/STAT3/CCND1/ATM/PRKCA/CDK6/RPS6KA5/MAPK1/PDCD4/ROCK1/SERPINB5/PIK3R1/SOS1/CCND2/UBE2I/BCL2/NFKB1/CDKN1B/PIK3CA/RPTOR/SOS2/HDAC4/CD44/CCNG1/ZEB2/PRKCE/PIK3CD	-1.53777246991206
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/1095	54/9376	0.475697615423643	BCAT1/SMS/MDH2	-1.404997233218
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1095	26/9376	0.329329118370214	PLAAT2	-1.24520720549232
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1095	41/9376	0.417685711103686	PGAM1/BPGM	-1.35876239758776
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1095	79/9376	0.541933992254783	GSTK1/GSTP1/GSTO2/MGST3/AKR7A2	-1.48669369768114
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/1095	79/9376	0.541933992254783	AP2S1/VAMP2/CLTB/ATP6V1D/ATP6V1G1	-1.48669369768114
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/1095	55/9376	0.467048567870486	CERS6/KDSR/SGMS2	-1.44141497540054
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1095	27/9376	0.317131743615762	OXCT1	-1.29207443126534
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/1095	43/9376	0.398258468726771	ACSL3/ACADM	-1.43808609546166
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1095	70/9376	0.489288975864318	GSTK1/GSTP1/GSTO2/MGST3	-1.55953107887861
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1095	44/9376	0.389207139892071	PRF1/GZMB	-1.47667264704674
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1095	30/9376	0.285418569254186	PLAAT2	-1.42544600394563
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/1095	30/9376	0.285418569254186	NFKB1	-1.42544600394563
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1095	46/9376	0.372285090331546	EPRS1/BLVRA	-1.55185751510387
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1095	73/9376	0.469181209732908	GSTK1/GSTP1/GSTO2/MGST3	-1.65556986599486
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1095	31/9376	0.276211518633083	DPYD	-1.46775702213474
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1095	32/9376	0.267579908675799	PGM1	-1.50910733102514
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1095	88/9376	0.486508924865089	SERPINB2/CD59/CLU/CD55/F3	-1.75980455635034
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/1095	76/9376	0.450660898822398	ACSL3/SCP2/DBI/ACADM	-1.74846579191044
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/1095	103/9376	0.498789732677218	SLC1A5/COL17A1/COL12A1/KCNN4/COL7A1/PRSS3	-1.85985782764342
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1095	183/9376	0.608269082017117	XRN1/REXO2/XRN2/NOP10/IMP3/RRP7A/EIF6/GAR1/NXT1/RIOK1/XPO1/WDR43/RPP30	-1.94596968572148
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1095	65/9376	0.395194942044257	PRKACB/GNAQ/CREB1	-1.77920190521724
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1095	66/9376	0.389207139892071	SULT2B1/COMT/CYP7B1	-1.81068283454441
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/1095	52/9376	0.329329118370214	PRKACB/IGF1R	-1.76344246998265
NA	NA	hsa04081	Hormone signaling	16/1095	219/9376	0.625574946310544	GNG2/STAT3/IGF2/PRKACB/PIK3R1/GNAQ/IGF1R/GNB1/ADIPOR1/GNB5/PIK3CA/AVPR1A/PTHLH/GNAI3/ITGAV/PIK3CD	-2.0387391206823
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/1095	36/9376	0.237848807711821	PGM1	-1.66598179404966
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/1095	154/9376	0.556010199845816	PPCS/CMPK1/PTS/NME3/BCAT1/VKORC1/ADSS2/EPRS1/GCH1/PANK2	-2.02009642497859
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1095	54/9376	0.317131743615762	PRF1/GZMB	-1.82991349857675
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1095	41/9376	0.208842855551843	GABRP	-1.84607281489958
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/1095	45/9376	0.190279046169457	ABCD3	-1.97983430761525
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/1095	95/9376	0.360528719057919	ATP6V1D/TGFB1/ITGAL/ATP6V1G1	-2.27791107754725
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/1095	65/9376	0.263463294696171	MBOAT2/AGPAT4	-2.16672710008138
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1095	100/9376	0.342502283105023	IL2RG/CCR7/CX3CR1/XCL2	-2.40361654407692
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/1095	82/9376	0.208842855551843	CREB1/KLRD1	-2.61649344988573
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/1095	63/9376	0.135913604406755	PLAAT2	-2.50226871581915
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1095	68/9376	0.125919957023905	CYP26B1	-2.630442295482
NA	NA	hsa04082	Neuroactive ligand signaling	9/1095	199/9376	0.387251325118744	GNG2/PRKCB/PRKACB/PRKCA/GNAQ/GNB1/GABRP/GNB5/GNAI3	-3.17694618696952
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1095	86/9376	0.0995646171816927	PRKACB	-3.05031876510151
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/1095	298/9376	0.431001195182495	TNFRSF12A/IL2RG/IL7R/TGFBR2/TGFB1/IL21R/IL36RN/CCR7/CX3CR1/CD27/IL17RC/ACVR2A/XCL2/IFNGR1/RELL1	-3.62974154645314
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/1095	90/9376	0.0951395230847286	PRKACB	-3.13646062470897
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/1095	370/9376	0.254562507713193	GZMA/P2RY8/NR3C1/TSPO/GABRP/LYPD6B/PGRMC2/AVPR1A/PRSS3/S1PR5/PTGDR	-5.31982600730903
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1095	449/9376	0.0762811320946599	PRKACB/NCALD/CAMK2D/GNB1	-7.29392886031254