category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	81/1096	238/9376	2.91148868306447	RPL34/RPS27/RPS21/RPL39/RPS28/RPL37/RPL30/RPL37A/RPL35A/RPL21/RPS27A/RPS29/RPL38/RPS4X/RPL36/RPS23/RPS13/RPL27A/UBA52/RPL11/RPL36AL/RPL35/RPS15/RPS8/RPL32/RPL8/FAU/RPL6/RPL28/MAPK8/RPS24/RPL14/RPL24/RPS12/RPS7/STAT1/RPS15A/RPL22/RPL23/RPS20/RPL7/RPL12/RPL9/RPLP2/RPL10A/RPL3/PRKCA/RPL10/TRAF3/RPL41/RPL13/RPL31/RSL24D1/RPS14/RPL15/RPL18/RPS10-NUDT3/CXCL8/RPS11/JAK1/RPS6/PRKCB/RPS3/RPL5/C1S/MX2/RPS27L/RPL22L1/RPL19/NFKB1/C7/RPS3A/PIK3R1/RPSA/RPS19/RPS16/EIF2AK2/PIK3CD/TAB2/MAPK14/PIK3CB	10.8670178313085
Genetic Information Processing	Translation	hsa03010	Ribosome	75/1096	222/9376	2.89011639376603	RPL34/RPS27/RPS21/RPL39/RPS28/RPL37/RPL30/RPL37A/RPL35A/RPL21/RPS27A/RPS29/RPL38/RPS4X/RPL36/RPS23/RPS13/RPL27A/UBA52/RPL11/RPL36AL/RPL35/RPS15/RPS8/RPL32/RPL8/FAU/RPL6/RPL28/RPS24/RPL14/RPL24/RPS12/RPS7/RPS15A/RPL22/RPL23/RPS20/RPL7/RPL12/RPL9/RPLP2/RPL10A/RPL3/RPL10/RPL41/RPL13/RPL31/RSL24D1/MRPL20/RPS14/RPL15/RPL18/RPS10-NUDT3/MRPL42/MRPL1/MRPS21/RPS11/RPS6/MRPL54/RPS3/RPL5/RPS27L/MRPL33/RPL22L1/RPL19/MRPL51/MRPL41/RPS3A/RPSA/RPS19/RPS16/MRPS25/MRPL47/MRPL52	10.3689631011015
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	68/1096	205/9376	2.83767135481574	COX7C/ATP5F1E/UQCRB/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/NDUFB1/NDUFB2/COX4I1/ATP5PF/PRKCA/UQCR11/NDUFA1/CYBA/RAC2/COX7A2L/COX7B/TGFBR2/COX5B/RAC1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/CAMK2D/NDUFA2/ATP5F1C/NDUFA12/PRKCB/PLCB1/NDUFS6/ATP5PD/UQCRFS1/PPP1CA/NDUFS5/NDUFV2/PPP1CB/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/NDUFAB1/NFKB1/NDUFB11/ATP5MC2/ATP5PB/PIK3R1/NDUFB5/ATP5MC1/GSK3B/PPIF/PIK3CD/MPC1/COX7A1/VDAC1/COL3A1/SMAD2/NDUFB3/SDHB/NDUFB6/NDUFS4/MPC2/MAPK14/PIK3CB	9.67859186148293
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	88/1096	308/9376	2.44421272158498	COX7C/ATP5F1E/UQCRB/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/POLR2L/NDUFB1/NDUFB2/NRF1/COX4I1/GNAQ/AMBRA1/PSMA7/TAF4B/ATP5PF/UQCR11/NDUFA1/RCOR1/COX7A2L/COX7B/PSMA1/DCTN4/SEM1/COX5B/PSMB1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/ATP5F1C/NDUFA12/PLCB1/NDUFS6/GPX1/ATP5PD/UQCRFS1/MAP3K5/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/CREB1/ATP5PO/NDUFAB1/PSMD8/POLR2G/POLR2K/NDUFB11/ACTR10/ATP5MC2/DCTN3/ATP5PB/CYCS/NDUFB5/ATP5MC1/CREBBP/PSMD7/AP2B1/PSMA3/ATG14/ITPR1/PPIF/PSMC5/PSMB7/PIK3C3/COX7A1/CLTB/PSMA5/POLR2I/POLR2F/VDAC1/HDAC1/NDUFB3/SDHB/WIPI1/NDUFB6/ATG13/PSMD4/TGM2/NDUFS4/PSMB2	9.37619251057139
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	53/1096	138/9376	3.28551782502909	COX7C/ATP5F1E/UQCRB/ATP6V1G1/NDUFA4/UQCR10/COX6C/COX6B1/COX7A2/ATP5ME/NDUFB1/NDUFB2/COX4I1/ATP5PF/ATP6V0E1/UQCR11/NDUFA1/COX7A2L/COX7B/COX5B/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/ATP5F1C/NDUFA12/NDUFS6/ATP5PD/UQCRFS1/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/COX17/NDUFAB1/ATP5MF/NDUFB11/ATP5MC2/ATP5PB/CYCS/NDUFB5/ATP5MC1/PPA1/PPA2/COX7A1/NDUFB3/SDHB/NDUFB6/NDUFS4	9.84035857065654
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	96/1096	368/9376	2.23167248492542	COX7C/ATP5F1E/UQCRB/BCL2/NDUFA4/UQCR10/COX6C/NUP98/COX6B1/COX7A2/NDUFB1/NDUFB2/COX4I1/AMBRA1/PSMA7/ATP5PF/UQCR11/RAB1A/NDUFA1/ACTG1/COX7A2L/HNRNPA1/COX7B/PSMA1/DCTN4/ACTB/SEM1/PRKN/COX5B/PSMB1/RAC1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/TANK/XBP1/ATP5F1C/NDUFA12/PFN1/NDUFS6/MCU/GPX1/ATP5PD/UQCRFS1/MAP3K5/NDUFS5/NDUFV2/MATR3/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/RANBP2/NDUFAB1/PPP3CC/PSMD8/NDUFB11/ACTR10/SEC13/ATP5MC2/NUP133/PPP3CA/DCTN3/PPP3CB/ATP5PB/CYCS/NUP214/NDUFB5/ATP5MC1/PSMD7/PSMA3/ANXA7/NUP54/ATG14/PSMC5/PSMB7/PIK3C3/ANXA11/COX7A1/PSMA5/VDAC1/NDUFB3/SDHB/EIF2AK3/WIPI1/NDUFB6/ATG13/PSMD4/RAB8A/NDUFS4/SPG11/PSMB2/MAPK14	8.76961862384636
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	79/1096	275/9376	2.45754479097545	COX7C/ATP5F1E/UQCRB/FYN/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/NDUFB1/NDUFB2/COX4I1/PSMA7/ATP5PF/UQCR11/NDUFA1/CYBA/RAC2/COX7A2L/COX7B/PSMA1/SEM1/COX5B/PSMB1/RAC1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/ATP5F1C/NDUFA12/NDUFS6/MCU/ATP5PD/UQCRFS1/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/CREB1/ATP5PO/NDUFAB1/PPP3CC/PSMD8/C7/NDUFB11/CSNK2A1/ATP5MC2/PPP3CA/PPP3CB/ATP5PB/CYCS/PIK3R1/NDUFB5/ATP5MC1/PSMD7/PSMA3/GSK3B/ITPR1/PPIF/PSMC5/PIK3CD/PSMB7/COX7A1/PSMA5/VDAC1/NDUFB3/SDHB/EIF2AK3/NDUFB6/PSMD4/NDUFS4/PSMB2/MAPK14/PIK3CB	8.92523061163974
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	77/1096	268/9376	2.45789301666848	RPS27A/COX7C/ATP5F1E/UQCRB/UBA52/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/CALM1/NDUFB1/NDUFB2/COX4I1/PSMA7/ATP5PF/SLC18A2/UQCR11/NDUFA1/COX7A2L/COX7B/PSMA1/SEM1/PRKN/PARK7/COX5B/PSMB1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/CAMK2D/NDUFA2/XBP1/ATP5F1C/NDUFA12/NDUFS6/MCU/UBE2L3/ATP5PD/UQCRFS1/MAP3K5/NDUFS5/TXN/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/NDUFAB1/PSMD8/NDUFB11/ATP5MC2/ATP5PB/CYCS/NDUFB5/NFE2L2/ATP5MC1/PSMD7/PSMA3/ITPR1/PPIF/PSMC5/PSMB7/COX7A1/PSMA5/VDAC1/UBE2L6/NDUFB3/SDHB/EIF2AK3/NDUFB6/PSMD4/NDUFS4/PSMB2	8.80962229100107
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	68/1096	227/9376	2.56265474774108	COX7C/ATP5F1E/UQCRB/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/NDUFB1/NDUFB2/MAP2K4/COX4I1/ATP5PF/UQCR11/NDUFA1/CYBA/BRAF/COX7A2L/COX7B/COX5B/RAC1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/ATP5F1C/NDUFA12/PTPRJ/SOS1/NDUFS6/ATP5PD/UQCRFS1/MAP3K5/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/NDUFAB1/SOS2/NFKB1/NDUFB11/ATP5MC2/ATP5PB/PIK3R1/NDUFB5/NFE2L2/ATP5MC1/HIF1A/PTPN1/PPIF/PIK3CD/COX7A1/VDAC1/RAF1/NDUFB3/SDHB/NDUFB6/ACP1/NDUFS4/MGST1/MAP2K1/MAPK14/PIK3CB	8.67091437228841
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	69/1096	235/9376	2.5118186053735	COX7C/ATP5F1E/UQCRB/NDUFA4/UQCR10/COX6C/COX6B1/COX7A2/ATP5ME/NDUFB1/NDUFB2/COX4I1/ATP5PF/COA1/UQCR11/NDUFA1/ACTG1/COX7A2L/COX7B/ACTB/RPTOR/COX5B/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/COX14/NDUFA2/ATP5F1C/NDUFA12/ARID1B/RPS6/SMARCC1/SOS1/NDUFS6/ATP5PD/UQCRFS1/RPS6KA3/MAP3K5/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/CREB1/ATP5PO/COX17/NDUFAB1/ATP5MF/SOS2/NDUFAF8/NDUFAF2/NDUFB11/NDUFAF7/ATP5MC2/ATP5PB/NDUFB5/NDUFAF6/ATP5MC1/COX7A1/FRS2/NDUFB3/SDHB/NDUFB6/PRKAA1/NDUFS4/ACTL6A/MAPK14	8.5391080563716
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/1096	122/9376	3.15543855450521	CD3G/CD3D/CD3E/CD247/FYN/MAPK8/ITK/PRKCQ/CBLB/VAV1/CARD11/RASGRP1/CD8B/LCK/PPP2R5C/PAK2/DLG1/MALT1/NFATC2/ICOS/SOS1/GRAP2/PPP2R2D/PPP3CC/CD8A/SOS2/NFKB1/NCK2/PPP3CA/PPP3CB/LAT/PIK3R1/PPP2R3C/CD4/PPP2R5A/GSK3B/PPP2R3A/PIK3CD/CD28/PAK1/RAF1/VAV3/MAP2K1/MAPK14/PIK3CB	8.71819465525969
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	109/1096	480/9376	1.9426399026764	RPS27A/COX7C/ATP5F1E/UQCRB/UBA52/BCL2/NDUFA4/MAPK8/DKK1/UQCR10/COX6C/COX6B1/COX7A2/CALM1/NDUFB1/NDUFB2/COX4I1/GNAQ/AMBRA1/PSMA7/ATP5PF/PRKCA/UQCR11/RAB1A/NDUFA1/BRAF/COX7A2L/COX7B/PSMA1/DCTN4/SEM1/PRKN/PARK7/COX5B/PSMB1/RAC1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/CAMK2D/NDUFA2/TANK/XBP1/ATP5F1C/NDUFA12/PRKCB/PLCB1/NDUFS6/MCU/UBE2L3/GPX1/ATP5PD/UQCRFS1/MAP3K5/PSEN1/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/NDUFAB1/PPP3CC/PSMD8/NFKB1/NDUFB11/ACTR10/CSNK2A1/ATP5MC2/PPP3CA/DCTN3/PPP3CB/ATP5PB/CYCS/ATXN1/NDUFB5/ATP5MC1/PSMD7/PSMA3/GSK3B/ATG14/ITPR1/PPIF/PSMC5/PSMB7/PIK3C3/COX7A1/PSMA5/FRAT2/VDAC1/RAF1/UBE2L6/WNT5A/NDUFB3/SDHB/EIF2AK3/WIPI1/NDUFB6/ATG13/PSMD4/RAB8A/NDUFS4/MAP2K1/SPG11/PSMB2/MAPK14/ATXN3	7.71338125849836
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	50/1096	157/9376	2.72444093170301	COX7C/UQCRB/NDUFA4/MAPK8/UQCR10/COX6C/COX6B1/COX7A2/NDUFB1/NDUFB2/COX4I1/UQCR11/NDUFA1/COX7A2L/COX7B/COX5B/RAC1/NDUFB4/NDUFC1/CXCL8/NDUFB7/NDUFA2/XBP1/NDUFA12/NDUFS6/UQCRFS1/MAP3K5/NDUFS5/NDUFV2/UQCRQ/UQCRH/NDUFA5/NDUFAB1/SOCS3/NFKB1/NDUFB11/CYCS/PIK3R1/NDUFB5/GSK3B/PIK3CD/COX7A1/NDUFB3/SDHB/EIF2AK3/NDUFB6/PRKAA1/NDUFS4/MAPK14/PIK3CB	7.92742219765337
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	91/1096	388/9376	2.00639626758974	COX7C/ATP5F1E/UQCRB/NDUFA4/MAPK8/DKK1/UQCR10/COX6C/COX6B1/COX7A2/CALM1/NDUFB1/NDUFB2/COX4I1/GNAQ/AMBRA1/PSMA7/ATP5PF/UQCR11/NDUFA1/BRAF/COX7A2L/COX7B/PSMA1/SEM1/COX5B/PSMB1/NDUFB4/NDUFC1/ATP5MC3/NDUFB7/NDUFA2/XBP1/ATP5F1C/NDUFA12/PLCB1/NDUFS6/MCU/ATP5PD/UQCRFS1/MAP3K5/PSEN1/NDUFS5/NDUFV2/ATP5F1D/UQCRQ/UQCRH/NDUFA5/ATP5PO/NDUFAB1/PPP3CC/PSMD8/NFKB1/NDUFB11/CSNK2A1/ATP5MC2/PPP3CA/PPP3CB/ATP5PB/CYCS/PIK3R1/NDUFB5/ATP5MC1/PSMD7/PSMA3/GSK3B/ATG14/ITPR1/PPIF/EIF2AK2/PSMC5/PIK3CD/PSMB7/PIK3C3/COX7A1/PSMA5/FRAT2/VDAC1/RAF1/WNT5A/NDUFB3/SDHB/EIF2AK3/WIPI1/NDUFB6/ATG13/PSMD4/NDUFS4/MAP2K1/PSMB2/PIK3CB	7.36595557506759
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1096	142/9376	2.65076590932456	RPS27A/UBA52/PIAS1/ANAPC16/UBE2Q1/CBLB/ELOB/COP1/UBE2B/HERC1/NEDD4/CUL3/BIRC6/UBE2K/UBE2D2/PRKN/UBE2E2/RBX1/FBXW11/UBE2O/CUL2/WWP2/UBE2L3/BTRC/UBR5/ANAPC11/UBE4A/UBE4B/HUWE1/FBXW7/SOCS3/UBE3A/UBE2E1/CDC27/HERC4/UBA2/CUL1/UBE2L6/CUL5/UBE2E3/CDC26/UBE3C/STUB1/BRCA1	7.2112487296813
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	16/1096	31/9376	4.41535201318578	SRP14/SPCS2/SPCS1/SEC62/IMMP2L/SEC61G/SRP9/SEC61B/SEC11A/SEC11C/SRP72/IMMP1L/SRP54/SPCS3/SEC63/SRPRA	6.92950820104654
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	59/1096	253/9376	1.99497994864545	H3-3A/H3-3B/RPS27A/U2AF1/UBA52/SEPTIN6/MYL12A/BCL2/ELMO1/MAPK8/PRKCQ/ARPC5/SEPTIN7/MYL12B/ARPC3/FNBP1/RPS6KA5/CYTH1/ACTG1/ARPC2/UBE2D2/ACTB/RPTOR/ACTR3/FOXO1/RAC1/PRKCE/RBX1/CXCL8/FBXW11/MALT1/PFN1/PLCB1/BTRC/H3C4/ATG5/UBE2V2/CAST/NFKB1/WASF2/CYCS/PIK3R1/SEPTIN9/CUL1/MYL9/GSK3B/ATG14/ITPR1/BNIP3/PIK3CD/PIK3C3/PXN/VDAC1/GLMN/WIPI1/NOD1/TAB2/MAPK14/PIK3CB	5.83688986450299
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	37/1096	144/9376	2.19809407948094	MAPK8/PUM2/GNAQ/AMBRA1/PSMA7/PRKCA/PSMA1/SEM1/PUM1/PSMB1/XBP1/PRKCB/PLCB1/ATXN10/MCU/MAP3K5/PSMD8/CYCS/ATXN1/PIK3R1/PSMD7/PSMA3/ATG14/ITPR1/PPIF/PSMC5/PIK3CD/PSMB7/PIK3C3/PSMA5/VDAC1/WIPI1/ATG13/PSMD4/PSMB2/PIK3CB/ATXN3	5.2710849696585
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	27/1096	90/9376	2.56642335766423	CD3G/CD3D/CD3E/CD247/PRKCQ/STAT1/EML4/RASGRP1/LCK/NFATC2/JAK1/PPP3CC/NFKB1/CSNK2A1/PPP3CA/PPP3CB/LAT/PIK3R1/CD4/HIF1A/PIK3CD/CD28/MAP3K3/RAF1/MAP2K1/MAPK14/PIK3CB	5.43240089895107
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	35/1096	138/9376	2.16968158256638	ELMO1/MAPK8/ARPC5/MAP2K4/ARPC3/VAV1/GNAQ/ARHGEF7/ACTG1/RAC2/ARPC2/CD8B/LCK/ACTB/ACTR3/RAC1/CXCL8/NFATC2/WIPF1/RPS6KA3/ITGA4/CD8A/NFKB1/WASF2/LAT/PIK3R1/CD4/GSK3B/PIK3CD/PXN/TAB2/VAV3/MAP2K1/MAPK14/PIK3CB	5.03609556657021
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	41/1096	174/9376	2.01577313533015	MARCHF6/BCL2/MAPK8/TMEM258/SEC62/SSR4/SEC61G/DAD1/MAN1C1/UBE2D2/PRKN/SEC24B/SEC61B/RBX1/PDIA3/CRYAB/XBP1/SSR2/SVIP/PDIA6/SEC31A/MAP3K5/ERP29/OSTC/UBE4B/SEC23B/SEC13/NFE2L2/CUL1/PLAA/KRTCAP2/MAGT1/RAD23B/LMAN2/EDEM3/EIF2AK3/SEC63/DDOST/STUB1/NPLOC4/ATXN3	4.92046309934716
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	26/1096	93/9376	2.3916490071423	MYL12A/FYN/RAP1B/IGF1R/MYL12B/RAP1A/LEF1/ACTG1/RAC2/CCM2/FER/TGFBR2/ACTB/YES1/RAC1/TCF7/PTPRJ/NLK/PDCD10/WASF2/CSNK2A1/CREBBP/MYL9/PTPN1/ACP1/HEG1	4.90684975157046
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	46/1096	214/9376	1.83887031857562	CD3G/CD3D/CD3E/CD247/BCL2/CXCR4/MAPK8/CALM1/GNG2/ELOB/GNAQ/CFL1/PRKCA/RAC2/GNB1/GNB5/PAK2/RAC1/RBX1/PDIA3/FBXW11/GNG5/NFATC2/SAMHD1/PRKCB/BTRC/PPP3CC/NFKB1/ATR/PPP3CA/PPP3CB/CYCS/PIK3R1/AP1G1/CUL1/CD4/ITPR1/PIK3CD/PAK1/PXN/RAF1/CUL5/TAB2/MAP2K1/MAPK14/PIK3CB	4.51629516802758
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	31/1096	125/9376	2.12157664233577	FYN/BCL2/MAPK8/GNAQ/PRKCA/RAC2/CERS6/ORMDL1/PPP2R5C/SGMS1/RAC1/PRKCE/PRKCB/PLCB1/MAP3K5/PPP2R2D/NFKB1/PIK3R1/PPP2R3C/NSMAF/PPP2R5A/PPP2R3A/CERS5/SPTLC1/PIK3CD/RAF1/GAB2/SPTLC2/MAP2K1/MAPK14/PIK3CB	4.59267135587659
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	51/1096	248/9376	1.75924181775371	RHOH/DYNLT1/MYL12A/BCL2/ELMO1/MAPK8/ARPC5/EXOC4/MYL12B/MAP2K4/ARPC3/LEF1/SNX9/CYFIP2/CYTH1/ACTG1/S100A10/ARPC2/BRK1/DCTN4/ACTB/ACTR3/RAC1/TCF7/CXCL8/PFN1/RPS3/TXN/ABI1/ARL8B/RAB7A/NFKB1/EXOC2/ACTR10/DCTN3/CYCS/RALA/CSE1L/MYL9/PIK3CD/PIK3C3/PAK1/RAF1/NOD1/AHNAK2/DNM2/TAB2/MAP2K1/VPS41/MAPK14/PIK3CB	4.40853092744377
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	30/1096	120/9376	2.13868613138686	CAMK4/ARHGDIB/BCL2/MAPK8/RAP1B/CALM1/RAP1A/RPS6KA5/BRAF/RAC1/CAMK2D/SOS1/RPS6KA3/MAP3K5/PSEN1/MAP2K5/SOS2/NFKB1/PIK3R1/GSK3B/RAPGEF1/PIK3CD/FRS2/MAP3K3/RAF1/KIDINS220/MAP2K1/MAPK14/PIK3CB/BEX3	4.56729147367179
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	42/1096	193/9376	1.86165424908286	GRK5/PIK3R5/ELMO1/CXCR4/ITK/STAT1/RAP1B/GNG2/RAP1A/VAV1/GNAQ/RAC2/BRAF/GNB1/GNB5/RAC1/CXCL8/GNG5/DOCK2/PRKCB/PLCB1/SOS1/CCR9/STAT5B/CXCL14/TIAM1/SOS2/NFKB1/PIK3R1/RASGRP2/JAK3/GSK3B/CXCL2/PIK3CD/PAK1/PXN/XCL2/RAF1/VAV3/GRK6/MAP2K1/PIK3CB	4.40043026742915
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	20/1096	67/9376	2.55365508225297	CAMK4/RAP1B/CALM1/RAP1A/GNAQ/PRKCA/BRAF/CAMK2D/PRKCB/PLCB1/PPP1CA/RPS6KA3/PPP1CB/PPP3CC/PPP3CA/PPP3CB/CREBBP/ITPR1/RAF1/MAP2K1	4.64318773003898
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	42/1096	196/9376	1.83315954118874	RPS27A/UBA52/PIK3R5/MAPK8/STAT1/CALM1/GNG2/MAP2K4/LEF1/TRAF3/GNB1/GNB5/CDK6/RAC1/TCF7/CXCL8/GNG5/NFATC2/JAK1/CREB1/PPP3CC/NFKB1/RB1/PPP3CA/PPP3CB/CYCS/PIK3R1/CREBBP/HIF1A/ANGPT2/GSK3B/ATG14/ITPR1/CXCL2/EIF2AK2/PIK3CD/PIK3C3/CLEC2B/RAF1/MAP2K1/MAPK14/PIK3CB	4.28855134534334
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	50/1096	250/9376	1.71094890510949	RAB11A/GRK5/CXCR4/ASAP1/CAPZA1/ARPC5/CBLB/IGF1R/ARPC3/SH3KBP1/NEDD4/CYTH1/ARPC2/TGFBR2/ACTR3/CAPZB/EPS15/ARFGEF2/GBF1/ARF5/IQSEC1/VPS37B/LDLRAP1/WIPF1/SMAP2/RABEP1/RAB7A/ACAP2/SMAP1/VPS4B/RAB10/CHMP2A/VPS36/AP2B1/ARFGEF1/VTA1/RBSN/SPART/SNX1/CLTB/RAB22A/SMAD2/ZFYVE27/DNM2/RAB8A/GRK6/BIN1/MVB12B/TSG101/EEA1	4.14518491217729
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/1096	70/9376	2.44421272158498	RAP1B/ELOB/RAP1A/ETS1/BRAF/PAK2/RAC1/RBX1/CUL2/SOS1/SOS2/PIK3R1/CREBBP/HIF1A/RAPGEF1/PIK3CD/PAK1/RAF1/MAP2K1/PIK3CB	4.41239525636777
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	37/1096	169/9376	1.87293223340388	RPS27A/UBA52/BCL2/MAPK8/PRKCQ/IGF1R/AMBRA1/RAB1A/BIRC6/TAX1BP1/RPTOR/ATG7/TANK/MTMR3/ATG5/RAB7A/RUBCN/UVRAG/PIK3R1/GABARAPL2/IGBP1/HIF1A/ATG14/ITPR1/BNIP3/PIK3CD/PIK3C3/RAF1/ATG10/EIF2AK3/WIPI1/ATG13/RAB8A/PRKAA1/MAP2K1/VPS41/PIK3CB	4.16620425290555
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	17/1096	56/9376	2.59697601668405	MGAT4A/TMEM258/MGAT5/DAD1/MAN1C1/MAN2A1/ALG13/OSTC/ALG5/ST6GAL1/B4GALT1/KRTCAP2/MAGT1/FUT8/DPM3/DDOST/DHRSX	4.36074004653265
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	31/1096	138/9376	1.92171797313022	ANAPC16/IGF1R/CALM1/SPDYE2/PPP2R5C/YWHAB/RBX1/FBXW11/CAMK2D/BTRC/PPP1CA/RPS6KA3/SPDYE1/PPP1CB/SMC1B/ANAPC11/SPDYE18/PPP3CC/CDC27/PPP3CA/PPP3CB/CUL1/PPP2R5A/ITPR1/SMC3/CDC26/SPDYA/SPDYE21/MAP2K1/MAPK14/SPDYE5	3.96848156566214
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	19/1096	69/9376	2.3556542896435	FYN/MAPK8/MAP2K4/VAV1/PRKCA/RAC2/RAC1/SOS1/SOS2/LAT/PIK3R1/ALOX5AP/PIK3CD/RAF1/GAB2/VAV3/MAP2K1/MAPK14/PIK3CB	4.11191745616767
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	24/1096	98/9376	2.09503947564427	INPP4B/CALM1/INPP4A/PRKCA/PI4KA/ITPKB/PIP4K2A/PRKCB/PLCB1/INPP5A/MTMR3/PIK3R1/IP6K2/PI4K2B/ITPR1/BPNT2/PIK3CD/PIK3C3/MTMR1/SYNJ1/MTMR6/SACM1L/PIK3CB/MTM1	3.96452696609777
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/1096	98/9376	2.09503947564427	ASAP1/ARPC5/ARPC3/VAV1/CFL1/PRKCA/RAC2/ARPC2/ACTR3/RAC1/PRKCE/PRKCB/WASF2/LAT/PIK3R1/PIK3CD/PAK1/RAF1/GAB2/DNM2/VAV3/MAP2K1/BIN1/PIK3CB	3.96452696609777
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/1096	93/9376	2.11568950631819	CD3G/CD3D/MAML2/CD3E/CD247/STAT4/MAPK8/PRKCQ/STAT1/LCK/NFATC2/MAML3/JAK1/STAT5B/PPP3CC/NFKB1/PPP3CA/PPP3CB/LAT/CD4/JAK3/IL4R/MAPK14	3.93383730294817
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	45/1096	232/9376	1.65932544676567	TMSB4X/CYRIB/SSH2/MYL12A/CXCR4/ARPC5/MYL12B/ARPC3/VAV1/CFL1/ARHGEF7/CYFIP2/ACTG1/RAC2/ARPC2/BRAF/BRK1/ACTB/ACTR3/PAK2/RAC1/PIP4K2A/PFN1/SOS1/PPP1CA/PPP1CB/IQGAP2/ITGA4/TIAM1/SOS2/C7/FGD3/PPP1R12A/WASF2/PIK3R1/ARHGEF6/MYL9/PIK3CD/PAK1/PXN/RAF1/VAV3/PPP1R12B/MAP2K1/PIK3CB	3.69957186803473
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	14/1096	46/9376	2.60361789907966	PSME4/PSMA7/PSMA1/SEM1/PSMB1/PSMD8/POMP/PSMD7/PSMA3/PSMC5/PSMB7/PSMA5/PSMD4/PSMB2	3.96656646554016
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	33/1096	158/9376	1.78675043888016	STAG1/ANAPC16/CCND3/TFDP2/CCNH/STAG2/CDC14A/PPP2R5C/YWHAB/CDK6/RBX1/PDS5A/GADD45A/SMC1B/ANAPC11/PRKDC/CDKN1B/RB1/CDC27/ATR/RBL1/RBL2/WAPL/CREBBP/CUL1/PPP2R5A/GSK3B/BUB3/SMC3/SMAD2/HDAC1/SFN/CDC26	3.62846495039224
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/1096	109/9376	1.96209736824483	CD3G/CD3D/CD3E/CD247/IL21R/RUNX1/MAPK8/PRKCQ/STAT1/LCK/TGFBR2/NFATC2/JAK1/STAT5B/PPP3CC/NFKB1/PPP3CA/PPP3CB/LAT/CD4/HIF1A/JAK3/IL4R/SMAD2/MAPK14	3.67568631187057
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/1096	86/9376	2.08894924461042	MAPK8/CBLB/AREG/MAP2K4/PRKCA/BRAF/PAK2/CAMK2D/PRKCB/SOS1/STAT5B/CDKN1B/SOS2/NCK2/PIK3R1/GSK3B/PIK3CD/PAK1/RAF1/MAP2K1/PIK3CB	3.69083604641937
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1096	122/9376	1.89326313270312	STAT1/NCOA1/PRKCA/ACTG1/NCOA2/MED13L/MED4/ACTB/FOXO1/NCOA3/MED30/PRKCB/PLCB1/NCOR1/KAT2B/MED27/PIK3R1/MED14/CREBBP/HIF1A/GSK3B/PIK3CD/RAF1/HDAC1/ESR1/MAP2K1/PIK3CB	3.61301965810879
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1096	116/9376	1.91744273848477	RHOH/MYL12A/CXCR4/ITK/RAP1B/MYL12B/RAP1A/VAV1/PRKCA/CYBA/ACTG1/RAC2/TXK/ACTB/RAC1/CD99/PRKCB/ITGA4/PIK3R1/MYL9/PECAM1/PIK3CD/PXN/VAV3/MAPK14/PIK3CB	3.6172474216606
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	21/1096	87/9376	2.06493833375283	BCL2/MAPK8/AREG/LEF1/RAC2/BRAF/TGFBR2/RAC1/TCF7/GADD45A/SOS1/SOS2/CYCS/PIK3R1/RALA/GSK3B/PIK3CD/RAF1/SMAD2/MAP2K1/PIK3CB	3.63057449203293
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/1096	157/9376	1.74364219628993	CALM1/CCND3/ETS1/TGFBR2/FOXO1/CDK6/CXCL8/FBXW11/GADD45A/NFATC2/MCU/BTRC/PPP1CA/PPP1CB/PPP3CC/NFKB1/RB1/ATR/PPP3CA/RBL1/PPP3CB/PIK3R1/RBL2/ITPR1/PIK3CD/VDAC1/RAF1/SMAD2/HIPK2/MAP2K1/MAPK14/PIK3CB	3.41859529404615
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1096	77/9376	2.1109109868234	MAPK8/STAT1/RAC2/BRAF/TGFBR2/CDK6/RAC1/GADD45A/JAK1/NFKB1/RB1/PIK3R1/RALA/ARHGEF6/PIK3CD/RAF1/SMAD2/MAP2K1/PIK3CB	3.56108424162388
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	19/1096	77/9376	2.1109109868234	RUNX1/BRAF/TGFBR2/CDK6/GADD45A/SOS1/STAT5B/CDKN1B/SOS2/NFKB1/RB1/PIK3R1/PIK3CD/MECOM/RAF1/HDAC1/GAB2/MAP2K1/PIK3CB	3.56108424162388
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	42/1096	224/9376	1.60401459854015	CD3G/CD3D/CD3E/MAPK8/ANAPC16/TSPO/CRTC3/MAP2K4/CCND3/ETS1/LCK/TGFBR2/RELB/DLG1/NFATC2/JAK1/STAT5B/CREB1/ANAPC11/PPP3CC/NFKB1/RB1/CDC27/KAT2B/ATR/PPP3CA/PPP3CB/PIK3R1/CREBBP/CD4/JAK3/BUB3/POLB/PIK3CD/MAP3K3/VDAC1/SMAD2/CRTC1/CDC26/VAC14/MAP2K1/PIK3CB	3.3288113656871
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	21/1096	91/9376	1.97417181358787	IFITM1/VAV1/CARD11/RAC2/RAC1/MALT1/NFATC2/PRKCB/SOS1/PPP3CC/SOS2/NFKB1/PPP3CA/PPP3CB/PIK3R1/GSK3B/PIK3CD/RAF1/VAV3/MAP2K1/PIK3CB	3.39735592831913
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1096	149/9376	1.72243178366727	NDUFA4/MAPK8/GNG2/NDUFB1/NDUFB2/GNAQ/PRKCA/NDUFA1/GNB1/GNB5/NDUFB4/NDUFC1/NDUFB7/GNG5/NDUFA2/NDUFA12/PRKCB/PLCB1/NDUFS6/NDUFS5/NDUFV2/NDUFA5/NDUFAB1/NDUFB11/NDUFB5/ITPR1/NDUFB3/NDUFB6/NDUFS4/MAPK14	3.23396611752562
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/1096	76/9376	2.02612370341913	CAMK4/CAMK1D/IGF1R/CALM1/PRKCA/BRAF/CDK6/GADD45A/CAMK2D/PRKCB/SOS1/SOS2/RB1/PIK3R1/PIK3CD/RAF1/MAP2K1/PIK3CB	3.26768954551112
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	27/1096	133/9376	1.73667746007354	HCST/CD247/FYN/CD48/VAV1/PRKCA/RAC2/BRAF/LCK/RAC1/NFATC2/PRKCB/SOS1/PPP3CC/SOS2/PPP3CA/PPP3CB/LAT/PIK3R1/KLRC4-KLRK1/PIK3CD/PAK1/GZMB/RAF1/VAV3/MAP2K1/PIK3CB	3.11295234948819
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	17/1096	71/9376	2.0483191117508	MAPK8/STAT1/SOS1/ESR2/STAT5B/PRL/SOCS3/SOS2/NFKB1/PIK3R1/GSK3B/PIK3CD/RAF1/ESR1/MAP2K1/MAPK14/PIK3CB	3.22582078538009
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	15/1096	60/9376	2.13868613138686	PRKCA/RAC2/RAC1/NFATC2/PRKCB/PPP3CC/PPP3CA/PPP3CB/PIK3R1/PIK3CD/PXN/RAF1/MAP2K1/MAPK14/PIK3CB	3.21914592121243
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	18/1096	78/9376	1.97417181358787	INPP4B/INPP4A/PI4KA/ITPKB/PIP4K2A/PLCB1/INPP5A/MTMR3/IP6K2/PI4K2B/PIK3CD/PIK3C3/MTMR1/SYNJ1/MTMR6/SACM1L/PIK3CB/MTM1	3.14314080634506
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1096	78/9376	1.97417181358787	SEPTIN6/ELMO1/ARPC5/ARPC3/ACTG1/ARPC2/ACTB/ACTR3/RAC1/CD2AP/WASF2/PIK3R1/SEPTIN9/PIK3CD/PXN/CLTB/DNM2/PIK3CB	3.14314080634506
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	12/1096	44/9376	2.33311214333112	MGAT4A/TMEM258/DAD1/MAN1C1/MAN2A1/ALG13/OSTC/B4GALT1/KRTCAP2/MAGT1/FUT8/DDOST	3.22464124455212
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/1096	73/9376	1.99220077992201	EML4/PRKCA/BRAF/STK4/CDK6/GADD45A/PRKCB/SOS1/STAT5B/SOS2/RB1/PIK3R1/JAK3/PIK3CD/RAF1/MAP2K1/PIK3CB	3.09617308171411
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	37/1096	203/9376	1.55923914997663	MYL12A/FYN/BCL2/MAPK8/RAP1B/IGF1R/MYL12B/RAP1A/VAV1/CCND3/PRKCA/ACTG1/RAC2/BRAF/ACTB/PAK2/RAC1/PRKCB/SOS1/PPP1CA/PPP1CB/ITGA4/THBS1/SOS2/PPP1R12A/PIK3R1/MYL9/GSK3B/RAPGEF1/PIK3CD/PAK1/PXN/RAF1/VAV3/PPP1R12B/MAP2K1/PIK3CB	2.93066134455486
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1096	136/9376	1.69836839845427	CD3G/CD3D/CD3E/BCL2/MAPK8/STAT1/CBLB/EIF3H/CCND3/TRAF3/TNFAIP3/CDK6/JAK1/STAT5B/MX2/CDKN1B/NFKB1/CSNK2A1/CYCS/PIK3R1/JAK3/GSK3B/EIF2AK2/PIK3CD/CD28/TAB2/PIK3CB	2.98465264148889
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	37/1096	204/9376	1.55159582081008	LUM/DCN/IGF1R/VAV1/PRKCA/ACTG1/BRAF/ACTB/PDCD4/RAC1/CAMK2D/RPS6/PRKCB/SOS1/PPP1CA/PPP1CB/THBS1/TIAM1/SOS2/PPP1R12A/PIK3R1/PLAUR/HIF1A/ITPR1/PIK3CD/PAK1/PXN/FRS2/RAF1/SMAD2/WNT5A/ESR1/VAV3/PPP1R12B/MAP2K1/MAPK14/PIK3CB	2.89787584347238
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	37/1096	205/9376	1.54402706070856	H4C3/RASA2/CCND3/TRAF3/HDAC4/YWHAB/CDK6/RAC1/DLG1/JAK1/SP100/GTF2A2/STAT5B/CREB1/SND1/UBR4/CDKN1B/UBE3A/NFKB1/RB1/KAT2B/RBL1/PIK3R1/RBL2/CREBBP/H4C5/JAK3/POLB/EIF2AK2/H2BC12/GTF2E2/PIK3CD/PXN/TRAF1/HDAC1/VAC14/PIK3CB	2.86526525453097
NA	NA	hsa04517	IgSF CAM signaling	50/1096	299/9376	1.4305592852086	MYL12A/FYN/CD96/GRIP1/MAPK8/PRKCQ/ARPC5/RAP1B/CD48/MYL12B/RAP1A/ARPC3/VAV1/MYL6/CASK/PRKCA/CD2/ACTG1/ARPC2/RAPGEF2/LCK/MBP/ACTB/ACTR3/FOXO1/PAK2/RAC1/RASA1/ERC1/NLGN4X/PRKCB/CD2AP/ITGA4/ROBO1/NCK2/PALS2/PIK3R1/MYL9/GSK3B/PIK3CD/CD28/PAK1/PXN/CRTAM/SLIT2/VAV3/PLXNA4/MAP2K1/MAPK14/PIK3CB	2.75279032190469
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1096	133/9376	1.67235607266341	MAPK8/CALM1/GNG2/GNAQ/SLC18A2/PRKCA/PPP2R5C/GNB1/GNB5/GNG5/CAMK2D/PRKCB/PLCB1/PPP1CA/PPP1CB/CREB1/PPP2R2D/PPP3CC/PPP3CA/PPP3CB/PPP2R3C/PPP2R5A/GSK3B/PPP2R3A/ITPR1/MAPK14	2.84115169735378
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/1096	195/9376	1.5354669661239	H3-3A/H3-3B/H4C3/H2AZ2/H2AZ1/MACROH2A1/H2AJ/H2AC20/PRKCA/HDAC4/CYBA/ACTG1/RAC2/ACTB/SELPLG/ATG7/RAC1/PRKCB/PLCB1/H3C4/NFKB1/PIK3R1/H4C5/PPIF/HAT1/H2BC12/PIK3CD/VDAC1/RAF1/HDAC1/H2AC17/H2AC6/MAP2K1/MAPK14/PIK3CB	2.74903799584892
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	30/1096	163/9376	1.57449285746272	STAT4/BCL2/MAPK8/STAT1/MAP2K4/PRKCA/TRAF3/BRAF/TGFBR2/YWHAB/CXCL8/NFATC2/JAK1/PRKCB/SOS1/STAT5B/CREB1/SOS2/NFKB1/RB1/CYCS/PIK3R1/CREBBP/JAK3/PIK3CD/RAF1/TAB2/MAP2K1/MAPK14/PIK3CB	2.69186730157359
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1096	170/9376	1.55998282524689	IGF1R/LEF1/PRKCA/ACTG1/BRAF/TGFBR2/ACTB/CDK6/TCF7/GADD45A/ARID2/ARID1B/SMARCC1/PRKCB/SOS1/PBRM1/SOS2/RB1/PIK3R1/NFE2L2/GSK3B/PIK3CD/BRD7/FRAT2/RAF1/SMAD2/WNT5A/MGST1/MAP2K1/ACTL6A/PIK3CB	2.68064577654852
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	36/1096	205/9376	1.50229659960833	CD3G/CD3D/CD3E/CD247/BCL2/MAPK8/STAT1/MAP2K4/NEDD4/CCND3/TRAF3/SEM1/RELB/TNFAIP3/CDK6/RAC1/PDIA3/GADD45A/JAK1/CIR1/PSMD8/CDKN1B/NFKB1/RB1/CYCS/PIK3R1/PSMD7/JAK3/EIF2AK2/PSMC5/PIK3CD/HDAC1/TAB2/PSMD4/MAPK14/PIK3CB	2.64548052527445
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	23/1096	117/9376	1.68170191527856	H2AZ2/H2AZ1/MACROH2A1/H2AJ/H2AC20/ACTG1/BICRAL/MORF4L1/ACTB/ARID2/ARID1B/SMARCC1/PBRM1/MTA3/EPC2/EPC1/RSF1/ACTR6/BRD7/HDAC1/H2AC17/H2AC6/ACTL6A	2.6994864375494
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	26/1096	138/9376	1.61176346133503	PDE3B/MAPK8/CBLB/CALM1/BRAF/RPTOR/FOXO1/RPS6/SOS1/INPP5A/PPP1CA/PPP1CB/SOCS3/SOS2/PHKB/PIK3R1/PRKAR1B/GSK3B/PTPN1/RAPGEF1/PIK3CD/RAF1/PRKAR2A/PRKAA1/MAP2K1/PIK3CB	2.63396406452704
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1096	32/9376	2.40602189781022	RPTOR/ATG7/ATG5/GABARAPL2/IGBP1/PIK3C3/ATG10/WIPI1/ATG13	2.89852069641893
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	21/1096	105/9376	1.71094890510949	RPS27A/TOMM7/UBA52/MAPK8/ARIH1/USP15/AMBRA1/TOMM20/TAX1BP1/PRKN/MARCHF5/TBC1D15/HUWE1/RAB7A/CSNK2A1/FIS1/GABARAPL2/HIF1A/BNIP3/EIF2AK3/PHB2	2.66529629507714
Organismal Systems	Immune system	hsa04611	Platelet activation	24/1096	126/9376	1.62947514772332	MYL12A/APBB1IP/FYN/PIK3R5/RAP1B/MYL12B/RAP1A/GNAQ/RASGRP1/ACTG1/ACTB/STIM1/PLCB1/PPP1CA/PPP1CB/PPP1R12A/PIK3R1/RASGRP2/ITPR1/PIK3CD/COL3A1/TBXAS1/MAPK14/PIK3CB	2.58802663427857
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1096	133/9376	1.60803468525328	KLF2/MAPK8/IGF1R/BRAF/TGFBR2/STK4/FOXO1/IL7R/GADD45A/SOS1/NLK/CDKN1B/SOS2/PIK3R1/RBL2/C8orf44-SGK3/CREBBP/GABARAPL2/BNIP3/PIK3CD/RAF1/PRKAA1/MAP2K1/MAPK14/PIK3CB	2.56935104521937
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1096	101/9376	1.69400881694009	BCL2/MAPK8/STAT1/PRKCA/TGFBR2/FOXO1/RAC1/PRKCE/CXCL8/PRKCB/PLCB1/STAT5B/CDKN1B/NFKB1/PIK3R1/PIK3CD/COL3A1/SMAD2/MAPK14/PIK3CB	2.55119974340369
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	26/1096	142/9376	1.56636167369179	CAMK4/FYN/MAPK8/STAT1/CYBA/LCK/TGFBR2/RELB/RAC1/NFATC2/JAK1/CREB1/PPP3CC/SOCS3/NFKB1/PPP3CA/PPP3CB/PIK3R1/ITPR1/PIK3CD/SIRPG/GAB2/TAB2/MAP2K1/MAPK14/PIK3CB	2.47410906469542
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	36/1096	212/9376	1.4526924666024	SKAP1/APBB1IP/SIPA1L1/EVL/RAP1B/IGF1R/CALM1/RAP1A/VAV1/GNAQ/PRKCA/ACTG1/RAC2/RAPGEF2/BRAF/ACTB/RAC1/PFN1/PRKCB/PLCB1/THBS1/SIPA1L3/TIAM1/LAT/PIK3R1/RALA/RASGRP2/ANGPT2/RAPGEF1/PIK3CD/RAF1/MAGI3/VAV3/MAP2K1/MAPK14/PIK3CB	2.42551745544955
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1096	34/9376	2.26449119793903	POLR1F/POLR2L/POLR2G/POLR3GL/POLR2K/POLR1C/POLR2I/POLR2F/POLR3B	2.68726864310608
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	31/1096	178/9376	1.48987123759534	MAPK8/DKK1/TBL1X/LEF1/CCND3/PRKCA/RAC2/RAC1/RBX1/TCF7/FBXW11/NFATC2/CAMK2D/PRKCB/PLCB1/BTRC/PSEN1/NLK/PPP3CC/CSNK2A1/PPP3CA/PPP3CB/TBL1XR1/CREBBP/CUL1/GSK3B/CCDC88C/SENP2/FRAT2/WNT5A/INVS	2.40060654798794
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	21/1096	110/9376	1.63317850033179	PDE3B/MAPK8/ANAPC16/IGF1R/SPDYE2/BRAF/RPS6KA3/SPDYE1/ANAPC11/SPDYE18/CDC27/PIK3R1/PIK3CD/RAF1/CDC26/SPDYA/SPDYE21/MAP2K1/MAPK14/PIK3CB/SPDYE5	2.43025643319137
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/1096	154/9376	1.49985780642715	CAMK4/PIK3R5/CAMK1D/CALM1/GNAQ/MYL6/PRKCA/ACTG1/ACTB/NFATC2/CAMK2D/PRKCB/PLCB1/PPP1CA/PPP1CB/CACNB2/MAP2K5/PPP3CC/PPP1R12A/PPP3CA/PPP3CB/MYL9/ITPR1/RAF1/PRKAA1/PPP1R12B/MAP2K1	2.27546430606158
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1096	106/9376	1.61410274066933	ZEB1/BCL2/IGF1R/LEF1/BRAF/FOXO1/TCF7/SOS1/CREB1/CDKN1B/SOS2/NFKB1/RB1/PIK3R1/CREBBP/GSK3B/PIK3CD/RAF1/MAP2K1/PIK3CB	2.31328876197439
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1096	300/9376	1.34024330900243	RASA2/MAPK8/RAP1B/AREG/IGF1R/RAP1A/MAP2K4/PRKCA/RASGRP1/RPS6KA5/RAC2/RAPGEF2/BRAF/TGFBR2/RELB/STK4/PAK2/RAC1/RASGRF2/GADD45A/RASA1/MAP3K2/TAOK3/PRKCB/SOS1/RPS6KA3/MAP3K5/CACNB2/NLK/MAP4K4/MAP2K5/MAP4K3/PPP3CC/SOS2/NFKB1/PPP3CA/PPP3CB/RASGRP2/ANGPT2/PAK1/MECOM/MAP3K3/RAF1/MAX/TAB2/MAP2K1/MAPK14	2.17910784423396
Human Diseases	Substance dependence	hsa05034	Alcoholism	32/1096	191/9376	1.43325562731685	H3-3A/H3-3B/H4C3/H2AZ2/CAMK4/H2AZ1/MACROH2A1/H2AJ/H2AC20/CALM1/GNG2/SLC18A2/HDAC4/BRAF/GNB1/GNB5/GNG5/SOS1/PPP1CA/PPP1CB/H3C4/CREB1/SOS2/PKIA/H4C5/HAT1/H2BC12/RAF1/HDAC1/H2AC17/H2AC6/MAP2K1	2.20088353998535
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1096	87/9376	1.67161674637134	COX7C/UQCRB/UQCR10/COX6C/COX6B1/COX7A2/COX4I1/UQCR11/COX7A2L/COX7B/COX5B/UQCRFS1/CACNB2/UQCRQ/UQCRH/COX7A1/TPM4	2.28966743943304
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	31/1096	184/9376	1.44128847984767	SSH2/ABLIM1/MYL12A/FYN/CXCR4/MYL12B/CFL1/PRKCA/RAC2/PAK2/RAC1/RASA1/NFATC2/CAMK2D/SEMA4D/PPP3CC/ROBO1/NCK2/PPP3CA/PPP3CB/PIK3R1/MYL9/GSK3B/PIK3CD/PAK1/RAF1/WNT5A/EPHA4/SLIT2/PLXNA4/PIK3CB	2.19938997195947
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1096	142/9376	1.50611699393441	BCL2/KLF2/MAPK8/CALM1/MAP2K4/SUMO2/CYBA/ACTG1/RAC2/ACTB/RAC1/MAP3K5/TXN/SUMO1/MAP2K5/NFKB1/PIK3R1/NFE2L2/PECAM1/PIK3CD/ACVR2A/PRKAA1/MGST1/MAPK14/PIK3CB	2.21093463886287
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1096	68/9376	1.76127093173036	RUNX1/LEF1/BRAF/TCF7/SOS1/STAT5B/SOS2/NFKB1/PIK3R1/PIK3CD/RAF1/PIM2/MAP2K1/PIK3CB	2.29214064876503
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/1096	122/9376	1.54265884886921	MAPK8/STAT1/MAP2K4/GNAQ/PRKCA/PRKCB/PLCB1/SOS1/STAT5B/CREB1/SOCS3/SOS2/PIK3R1/CREBBP/GSK3B/ITPR1/PIK3CD/RAF1/CSHL1/MAP2K1/MAPK14/PIK3CB	2.19491549223354
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	35/1096	216/9376	1.38618545552852	BCL2/MAPK8/RAP1B/CALM1/RAP1A/MAP2K4/VAV1/PRKCA/TRAF3/CYBA/RAC1/CXCL8/NFATC2/CAMK2D/TANK/XBP1/PLCB1/POU2F1/MAP3K5/PPP3CC/NFKB1/PPP3CA/PPP3CB/CYCS/PIK3R1/NFE2L2/GSK3B/ITPR1/CXCL2/PIK3CD/EIF2AK3/TAB2/VAV3/MAPK14/PIK3CB	2.08905944909728
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1096	238/9376	1.36588357970926	RASA2/MAPK8/RAP1B/IGF1R/CALM1/GNG2/PLAAT2/RAP1A/PRKCA/RASGRP1/RAC2/ETS1/GNB1/GNB5/STK4/PAK2/RAC1/RASGRF2/RASA1/GNG5/PRKCB/SOS1/RALGAPA2/TIAM1/SOS2/NFKB1/EXOC2/LAT/PIK3R1/RALA/RASGRP2/ANGPT2/PIK3CD/PAK1/RAF1/GAB2/MAP2K1/PIK3CB	2.08008732675786
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1096	44/9376	1.9442601194426	TAF4B/CCNH/TAF3/GTF2A2/GTF2F2/MNAT1/TAF11/TAF10/GTF2E2/TAF2	2.28405400248764
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/1096	38/9376	2.02612370341913	CD3D/CD3E/CD8B/LCK/IL7R/ICOS/CD8A/CD4/JAK3	2.30589926193835
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1096	110/9376	1.55540809555408	BCL2/IGF1R/ELOB/PRKCA/RBX1/CAMK2D/RPS6/CUL2/PRKCB/CDKN1B/PDK1/NFKB1/PIK3R1/CREBBP/HIF1A/ANGPT2/PGK1/PIK3CD/MAP2K1/PIK3CB	2.13175920622635
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	24/1096	139/9376	1.47707819146143	BCL2/KRT24/OPRM1/CALM1/GNAQ/KRT10/NCOA1/NCOA2/KRT17/KRT14/NCOA3/PLCB1/SOS1/ESR2/CREB1/SOS2/PIK3R1/ITPR1/FKBP5/PIK3CD/RAF1/ESR1/MAP2K1/PIK3CB	2.06161345253663
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	15/1096	78/9376	1.64514317798989	CNOT6L/ZCCHC7/PAN3/LSM6/LSM7/XRN1/DDX6/C1D/EXOSC7/LSM5/LSM8/LSM3/TENT4B/DCP1A/MTREX	2.08153820547002
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1096	99/9376	1.55540809555408	BCL2/MAPK8/IGF1R/BRAF/NCOA3/SOS1/ESR2/NCOR1/CDKN1B/SOS2/RB1/PIK3R1/PIK3CD/RAF1/ESR1/MAP2K1/MAPK14/PIK3CB	2.02116501161617
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1096	99/9376	1.55540809555408	GPCPD1/MAPK8/PRKCA/RAC2/RAC1/CHKA/PRKCB/SOS1/CHPT1/SOS2/WASF2/PIK3R1/HIF1A/SLC44A2/PIK3CD/RAF1/MAP2K1/PIK3CB	2.02116501161617
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/1096	59/9376	1.7399480390944	LEF1/BRAF/TCF7/GADD45A/SOS1/SOS2/PIK3R1/GSK3B/PIK3CD/RAF1/MAP2K1/PIK3CB	2.07426829177076
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1096	80/9376	1.60401459854015	BCL2/IGF1R/PRKCA/BRAF/JAK1/RPS6/PRKCB/SOS1/SOS2/PIK3R1/GSK3B/PIK3CD/RAF1/MAP2K1/PIK3CB	1.97387714343026
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/1096	115/9376	1.48778165661695	CAMK4/FYN/PIK3R5/BCL2/GNG2/GNAQ/PRKCA/KCNQ5/GNB1/GNB5/GNG5/CAMK2D/PRKCB/PLCB1/CREB1/PIK3R1/ITPR1/PIK3CD/MAP2K1/PIK3CB	1.91479017006478
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	19/1096	108/9376	1.50500135171668	NUP98/XPO4/SUMO2/SUMO1/RANBP2/XPO6/SAP18/MAGOH/SEC13/NUP133/NUP214/CSE1L/UPF3A/NUP54/THOC7/IPO9/THOC1/SENP2/KPNA6	1.92037990417785
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/1096	103/9376	1.49500389766849	WDR33/RNMT/RNGTT/MSI2/PPP2R5C/CPSF6/PPP1CA/PPP1CB/SMG6/PPP2R2D/SAP18/MAGOH/PPP2R3C/PPP2R5A/PPP2R3A/UPF3A/SSU72/HBS1L	1.83777715214745
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/1096	227/9376	1.31901347310203	CXCR4/CALM1/GNG2/GNAQ/PRKCA/RAC2/GNB1/GNB5/CDK6/RAC1/PDIA3/CXCL8/GNG5/NFATC2/JAK1/PRKCB/PLCB1/SOS1/CREB1/PPP3CC/SOS2/NFKB1/RB1/PPP3CA/PPP3CB/CYCS/PIK3R1/GSK3B/ITPR1/PIK3CD/PXN/RAF1/MAP2K1/MAPK14/PIK3CB	1.77015333225247
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/1096	30/9376	1.99610705596107	OGDH/SUCLG2/SUCLA2/ACO2/SDHB/MDH1/DLD	1.98806006868751
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1096	69/9376	1.61176346133503	CAMK4/CALM1/SLC18A2/PRKCA/CAMK2D/PRKCB/PPP1CA/PPP1CB/CREB1/PPP3CC/PPP3CA/PPP3CB/HDAC1	1.85557695271304
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1096	63/9376	1.62947514772332	POLR2L/CCNH/RBX1/MNAT1/POLR2G/POLR2K/RPA3/RFC1/RAD23B/POLR2I/POLR2F/XPC	1.82381090678157
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1096	105/9376	1.46652763295099	BCL2/PRKCQ/CARD11/TRAF3/LCK/RELB/TNFAIP3/CXCL8/GADD45A/ERC1/MALT1/PRKCB/NFKB1/CSNK2A1/LAT/CXCL2/TRAF1/TAB2	1.74897853097317
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/1096	105/9376	1.46652763295099	MAPK8/STAT1/CBLB/CALM1/RELB/MALT1/NFATC2/PPP3CC/NFKB1/PPP3CA/PPP3CB/PIK3R1/ITPR1/PIK3CD/PAK1/RAF1/MAPK14/PIK3CB	1.74897853097317
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	17/1096	99/9376	1.46899653468997	PRKCH/MAPK8/PRKCQ/CALM1/GNAQ/PRKCA/PRKCE/CAMK2D/PRKCB/PLCB1/PPP1CA/PPP1CB/PIK3R1/ITPR1/PIK3CD/MAPK14/PIK3CB	1.70670790374226
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	15/1096	85/9376	1.50966079862602	ADSS2/ADK/NT5C2/APRT/AK5/RRM1/ASMTL/NME7/GUK1/DGUOK/CMPK1/HPRT1/ADA2/NT5E/NME3	1.71725666298003
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/1096	128/9376	1.40351277372263	PDE3B/ADSS2/PDE4D/PDE7A/PDE4B/ADK/PDE7B/NT5C2/APRT/AK5/RRM1/PDE5A/PDE8A/NME7/GUK1/DGUOK/HPRT1/ADA2/NT5E/NUDT5/NME3	1.67229968747117
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/1096	158/9376	1.35359881733346	ATP6V1G1/IGF1R/PRKCA/BRAF/RPTOR/LAMTOR4/RPS6/PRKCB/SOS1/RPS6KA3/MAPKAP1/SOS2/SLC38A9/LAMTOR1/SEC13/LAMTOR5/PIK3R1/GSK3B/FNIP2/PIK3CD/RAF1/WNT5A/PRKAA1/MAP2K1/PIK3CB	1.63078512802714
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1096	93/9376	1.47178400439526	MAPK8/CALM1/MAP2K4/GNAQ/PRKCA/CAMK2D/MAP3K2/PRKCB/PLCB1/SOS1/SOS2/ITPR1/MAP3K3/RAF1/MAP2K1/MAPK14	1.66347492282951
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1096	130/9376	1.38192026951151	MAPK8/GNG2/MAP2K4/PRKCA/TGFBR2/GNB1/GNB5/GNG5/PLCB1/SOS1/CREB1/SOS2/NFKB1/PIK3R1/PIK3CD/RAF1/COL3A1/SMAD2/MAP2K1/MAPK14/PIK3CB	1.59530301734683
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1096	73/9376	1.52344765523448	CXCR4/MLLT3/SERINC5/SAMHD1/CPSF6/MX2/RANBP2/PSIP1/VPS4B/KAT2B/CREBBP/CD4/TSG101	1.63342397286842
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/1096	109/9376	1.41271010513628	MAPK8/PRKCQ/FOXO1/PRKCE/PRKCB/PPP1CA/RPS6KA3/PPP1CB/CREB1/OGT/SOCS3/NFKB1/PIK3R1/GSK3B/PTPN1/PIK3CD/PRKAA1/PIK3CB	1.57675608965395
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1096	53/9376	1.61410274066933	RAB11A/GNAQ/PRKCA/PRKCB/PLCB1/ATP2B1/AP2B1/CLTB/DNM2/ESR1	1.63108605663506
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/1096	103/9376	1.41194812557579	CD3G/CD3D/CD3E/CD247/MAPK8/MAP2K4/GNAQ/TGFBR2/CXCL8/PLCB1/PPP2R2D/NFKB1/PIK3R1/PIK3CD/SMAD2/MAPK14/PIK3CB	1.52941998359816
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/1096	170/9376	1.30837269214255	ARHGEF18/MYL12A/RUNX1/MAPK8/ARPC5/MYL12B/RAP1A/ARPC3/MYL6/NEDD4/ACTG1/ARPC2/RAB8B/RAPGEF2/ACTB/ACTR3/RAC1/PRKCE/DLG1/MAP3K5/PPP2R2D/PATJ/TIAM1/MYL9/RAB8A/PRKAA1	1.4761844783907
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1096	34/9376	1.76127093173036	CRY1/RBX1/FBXW11/BTRC/CREB1/CUL1/PRKAA1	1.61783609651174
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1096	91/9376	1.41012272399134	PDE3B/PDE4D/PDE7A/GRK5/PDE4B/OPRM1/GNG2/PRKCA/PDE7B/GNB1/GNB5/GNG5/PRKCB/PDE8A/GRK6	1.43027425784238
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1096	107/9376	1.35916501807763	PDE3B/SIK1/CALM1/GNAQ/SIK2/FOXO1/CAMK2D/PPP4R3B/PLCB1/CREB1/PPP3CC/PHKB/PPP3CA/PPP3CB/CREBBP/ITPR1/PRKAA1	1.35939361372279
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/1096	137/9376	1.31131120464596	BCL2/CTSW/MAPK8/ACTG1/ACTB/GADD45A/MAP3K5/NFKB1/CYCS/PIK3R1/ITPR1/IL3RA/PIK3CD/TRAF1/GZMB/RAF1/EIF2AK3/CTSS/PARP4/MAP2K1/PIK3CB	1.33542129982508
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/1096	168/9376	1.27302745915885	PIAS1/IL21R/STAT4/BCL2/STAT1/CCND3/IL7R/JAK1/SOS1/STAT5B/PRL/SOCS3/SOS2/IL24/PTPN2/PIK3R1/CREBBP/JAK3/IL4R/IL3RA/PIK3CD/RAF1/CSHL1/OSM/PIK3CB	1.29913433191092
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1096	65/9376	1.44772599663111	GNAQ/PRKCA/PRKCB/PLCB1/ESR2/PIK3R1/ITPR1/PIK3CD/RAF1/MAP2K1/PIK3CB	1.31779111100406
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/1096	140/9376	1.28321167883212	CAMK4/PDE3B/PIK3R5/KLF2/CALM1/GNG2/NRF1/GNAQ/HDAC4/GNB1/GNB5/PRKCE/GNG5/RPS6/PLCB1/ITPR1/PIK3C3/RAF1/SMAD2/PRKAA1/MAP2K1	1.22831275324628
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1096	148/9376	1.27165121325705	IGF1R/LEF1/NCOA1/BRAF/CDK6/NCOA3/TCF7/GADD45A/SOS1/ESR2/SOS2/RB1/PIK3R1/GSK3B/PIK3CD/FRAT2/RAF1/WNT5A/ESR1/MAP2K1/BRCA1/PIK3CB	1.2118935126959
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/1096	156/9376	1.26127643645892	PIAS1/STAT1/EIF3E/TRAF3/BRAF/YWHAB/CDK6/JAK1/SOS1/MX2/PPP2R2D/SOCS3/SOS2/NFKB1/RB1/CYCS/PIK3R1/GSK3B/EIF2AK2/PIK3CD/RAF1/MAP2K1/PIK3CB	1.19721687489383
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/1096	250/9376	1.19766423357664	ATP6V1G1/CTSW/ATP6V0E1/SUMF1/RPTOR/LAMTOR4/WDR7/MEAK7/AP3B1/NPC1/LITAF/HGSNAT/AP3M2/ARL8B/RAB7A/SLC38A9/LAMTOR1/MANBA/ARSG/OSTM1/LAMTOR5/AP1G1/AP2B1/DMXL1/ABCA5/BLOC1S2/CLTB/MFSD8/OSBPL3/CTSS/GPR155/BORCS7/SPG11/VPS41/AP4S1	1.15248056901192
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1096	38/9376	1.57587399154821	PRKCA/PRKCB/NR3C2/PIK3R1/PIK3CD/SFN/PIK3CB	1.29410070896502
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1096	173/9376	1.23623475802709	RAB11A/STAT1/NUP98/CCND3/PRKCA/TRAF3/ACTG1/ACTB/CDK6/CXCL8/JAK1/PRKCB/MX2/SOCS3/NFKB1/CYCS/PIK3R1/CREBBP/EIF2AK2/PIK3CD/VDAC1/RAF1/KPNA6/MAP2K1/PIK3CB	1.14097961331459
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1096	32/9376	1.60401459854015	SUCLG2/SUCLA2/ECHDC1/PCCA/BCKDHB/DLD	1.2451789104668
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	45/1096	333/9376	1.15604655750641	MAML2/ATP6V1G1/STAT1/CCND3/ATP6V0E1/TRAF3/PPP2R5C/FOXO1/CDK6/TCF7/DLG1/MAML3/JAK1/SOS1/PSEN1/MX2/ITGA4/CREB1/THBS1/PPP2R2D/PATJ/UBR4/CDKN1B/SOS2/UBE3A/NFKB1/RB1/ATR/RBL1/NFX1/PIK3R1/RBL2/CREBBP/PPP2R3C/PPP2R5A/GSK3B/PPP2R3A/EIF2AK2/PIK3CD/PXN/RAF1/WNT5A/HDAC1/MAP2K1/PIK3CB	1.05486234674786
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	13/1096	83/9376	1.33989974496526	JARID2/MBD5/SFMBT2/UBE2D2/FOXK2/SCMH1/OGT/PHC3/CREBBP/HDAC1/SUZ12/MAX/KDM2B	1.13158625403449
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/1096	62/9376	1.37979750412056	IGF1R/RPTOR/FOXO1/CRYAB/ATG5/PIK3R1/PIK3CD/HDAC1/PRKAA1/PIK3CB	1.09158002848186
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1096	100/9376	1.28321167883212	CD3G/CD3D/CD3E/CD7/CD2/CD8B/IL7R/CD37/CD5/ITGA4/CD8A/CD4/IL4R/IL3RA/CD9	1.03587305245739
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1096	13/9376	1.97417181358787	XRCC5/XRCC6/PRKDC	1.27872003866634
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1096	41/9376	1.4605661385081	RPS6KA5/BRAF/CXCL8/THBS1/RB1/RAF1/MAP2K1	1.07523283680268
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	26/1096	187/9376	1.18942972012959	BCL2/MAPK8/STAT1/TRAF3/CYBA/TNFAIP3/CXCL8/TANK/JAK1/PLCB1/MCU/TXN/NEK7/ATG5/NLRP1/CARD8/NFKB1/CARD16/GABARAPL2/ANTXR2/ITPR1/CXCL2/VDAC1/NOD1/TAB2/MAPK14	0.951942117373954
Genetic Information Processing	Transcription	hsa03040	Spliceosome	33/1096	243/9376	1.16175542939533	U2AF1/SRSF5/SNRPB2/SNRPD2/LSM6/HNRNPA1/SF3B6/LSM7/BCAS2/SNRPF/ZMAT2/SRSF4/TXNL4A/SYF2/CDC40/SNRPG/MAGOH/SNRPE/CCDC12/SNRPD1/LSM5/PRPF6/THOC7/LSM8/LSM3/THOC1/CWC15/SF3B5/AQR/YJU2/U2SURP/PRPF18/SNRPC	0.929460679310677
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/1096	71/9376	1.32538295466228	ATP6V1G1/MAPK8/MAP2K4/ATP6V0E1/RAC1/CXCL8/NFKB1/CXCL2/PAK1/NOD1/MAPK14	1.00124769890438
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	19/1096	134/9376	1.21298616407016	PRKCH/PRKCQ/CALM1/GNAQ/MYL6/PRKCA/BRAF/PRKCE/PRKCB/PLCB1/PPP1CA/PPP1CB/PPP1R12A/MYL9/ITPR1/RAF1/PPP1R12B/MAP2K1/RAMP1	0.903434260022205
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1096	14/9376	1.83315954118874	ST3GAL1/B4GALT1/FUT8	1.13496800401867
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/1096	119/9376	1.22210636079249	MAPK8/MAP2K4/RPS6KA5/TRAF3/TNFAIP3/MAP3K5/CREB1/SOCS3/NFKB1/PIK3R1/CXCL2/PIK3CD/TRAF1/TAB2/MAP2K1/MAPK14/PIK3CB	0.887105132586829
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	27/1096	200/9376	1.15489051094891	FYN/MAPK8/ARPC5/ARPC3/CYFIP2/RAB1A/CYTH1/ACTG1/ARPC2/BRK1/ACTB/ACTR3/PAK2/SEC24B/RAC1/CXCL8/WIPF1/RPS3/ABI1/TMED10/NFKB1/NCK2/WASF2/CYCS/PAK1/TAB2/MAPK14	0.805543234822875
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	47/1096	362/9376	1.11069887486389	PIK3R5/BCL2/AREG/IGF1R/GNG2/CCND3/PRKCA/PPP2R5C/RPTOR/GNB1/GNB5/YWHAB/CDK6/RAC1/IL7R/GNG5/JAK1/RPS6/SOS1/PRL/ITGA4/CREB1/THBS1/PPP2R2D/CDKN1B/SOS2/NFKB1/PIK3R1/RBL2/MTCP1/C8orf44-SGK3/PPP2R3C/ANGPT2/JAK3/PPP2R5A/GSK3B/PPP2R3A/IL4R/IL3RA/PIK3CD/RAF1/CSHL1/OSM/PRKAA1/MAP2K1/BRCA1/PIK3CB	0.781473871563783
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	27/1096	201/9376	1.14914478701384	H3-3A/H3-3B/ZEB1/KDM6A/RUNX1/ETV6/IGF1R/MLLT3/AFF1/BCL11B/TGFBR2/FOXO1/CXCL8/SUPT3H/GADD45A/NCOR1/H3C4/BMP2K/CDKN1B/NFKB1/FLI1/TRAF1/GZMB/FUT8/HDAC1/MAX/PBX3	0.777640404334678
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1096	90/9376	1.23568532035685	CAMK4/IGF1R/RPTOR/FOXO1/ATG5/CREB1/NFKB1/PIK3R1/EHMT1/PIK3CD/ATG13/PRKAA1/PIK3CB	0.817363415778804
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1096	15/9376	1.71094890510949	AK5/TPK1/ACP1	1.00253292261116
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/1096	226/9376	1.1355855564886	CAMK4/PDE3B/PDE4D/PDE4B/MAPK8/RAP1B/CALM1/RAP1A/VAV1/RAC2/BRAF/RAC1/CAMK2D/PPP1CA/PPP1CB/CREB1/TIAM1/ATP2B1/NFKB1/PPP1R12A/PIK3R1/CREBBP/MYL9/PIK3CD/PAK1/RAF1/ABCC4/VAV3/MAP2K1/PIK3CB	0.750641977387662
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1096	60/9376	1.28321167883212	IGF1R/GNAQ/PRKCA/BRAF/PRKCB/PLCB1/ITPR1/RAF1/MAP2K1	0.800659370147707
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/1096	115/9376	1.19022532529356	PDE4D/BCL2/NACA/PDE4B/GNAQ/PRKCA/BRAF/MMP24/OXSR1/PRKCB/PLCB1/CREB1/ITPR1/RAF1/STK39/MAP2K1	0.74673079241173
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/1096	93/9376	1.19582450357115	BCL2/TRAF3/CDK6/GADD45A/CDKN1B/NFKB1/RB1/CYCS/PIK3R1/PIK3CD/TRAF1/MAX/PIK3CB	0.690462474207224
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	14/1096	101/9376	1.18580617185806	CALM1/LEF1/GNAQ/PRKCA/TCF7/CAMK2D/PRKCB/PLCB1/CREB1/CREBBP/GSK3B/RAF1/WNT5A/MAP2K1	0.683029734488274
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/1096	166/9376	1.13376132266291	PDE3B/PIK3R5/CALM1/GNAQ/PRKCE/NFATC2/PLCB1/PDE5A/PPP1CA/PPP1CB/CREB1/PPP3CC/ATP2B1/PPP1R12A/PPP3CA/PPP3CB/MYL9/ITPR1/PPIF/VDAC1/RAF1/MAP2K1	0.632601955864562
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1096	70/9376	1.22210636079249	FYN/ACTG1/RAC2/ACTB/RAC1/SNTB1/SGCE/CYCS/CD28/EIF4G3	0.678584974445008
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1096	63/9376	1.22210636079249	SMYD3/CAMKMT/PHYKPL/ASH1L/KMT2C/EHMT1/SETD2/MECOM/DLD	0.64352024816865
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1096	17/9376	1.50966079862602	MARS1/MTR/KYAT3	0.765185469429556
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1096	48/9376	1.24756690997567	OXCT1/AUH/PCCA/HIBADH/BCKDHB/DLD/ACSF3	0.62559705106615
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1096	56/9376	1.22210636079249	BCL2/CUL3/FBXW11/BTRC/CUL1/DISP1/GSK3B/GAS1	0.606488821359096
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1096	33/9376	1.29617341296173	VTI1A/STX5/STX8/VAMP5/VAMP3	0.620062707590126
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	20/1096	154/9376	1.11100578253863	PIK3R5/BCL2/CALM1/GNAQ/PRKCA/RPS6KA5/PPP2R5C/CAMK2D/PLCB1/PPP1CA/PPP1CB/CACNB2/CREB1/PPP2R2D/ATP2B1/PPP2R3C/PPP2R5A/PPP2R3A/TPM4/MAPK14	0.505323099260025
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1096	97/9376	1.14651215290842	CALM1/GNG2/GNAQ/PRKCA/RPS6KA5/GNB1/GNB5/GNG5/CAMK2D/PRKCB/PLCB1/CREB1/ITPR1	0.527697062655804
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1096	41/9376	1.25191383300694	RAD51B/BABAM2/SEM1/RPA3/ABRAXAS1/BRCA1	0.588115370728951
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1096	73/9376	1.17188281171883	IGF1R/BRAF/CDK6/GADD45A/RB1/PIK3R1/PIK3CD/RAF1/MAP2K1/PIK3CB	0.536362141234159
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	16/1096	122/9376	1.12193370826852	IGF1R/RAB2A/PPP2R5C/RPTOR/FOXO1/CREB1/PPP2R2D/PIK3R1/RAB10/PPP2R3C/PPP2R5A/PPP2R3A/PIK3CD/RAB8A/PRKAA1/PIK3CB	0.493190493183235
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1096	18/9376	1.42579075425791	LMBRD1/MTR/ZNF76	0.65783459025225
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/1096	75/9376	1.14063260340633	BCL2/MAP3K5/REV3L/CYCS/PIK3R1/PIK3CD/SLC31A1/MGST1/BRCA1/PIK3CB	0.444864317996361
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/1096	75/9376	1.14063260340633	BCL2/COP1/CCND3/CDK6/GADD45A/THBS1/SIVA1/ATR/CYCS/SFN	0.444864317996361
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1096	59/9376	1.15996535939626	DPYD/NT5C2/RRM1/ASMTL/NME7/CMPK1/NT5E/NME3	0.448424828834575
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1096	19/9376	1.35074913561275	OGDH/BCKDHB/DLD	0.556776430036401
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1096	51/9376	1.17418062115357	ATP6V1G1/PRKCA/ATP6V0E1/SEC61G/ACTG1/ACTB/SEC61B	0.453770490645577
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1096	150/9376	1.08360097323601	BCL2/LEF1/BRAF/TGFBR2/TCF7/GADD45A/SOS1/CDKN1B/SOS2/RB1/PIK3R1/GSK3B/PIK3CD/FRAT2/RAF1/SMAD2/WNT5A/MAP2K1/PIK3CB	0.37551387155314
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/1096	109/9376	1.0987745262171	MAPK8/STAT1/MAP2K4/TRAF3/RAC1/CXCL8/JAK1/NFKB1/PIK3R1/PIK3CD/TAB2/MAP2K1/MAPK14/PIK3CB	0.377367391244455
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/1096	143/9376	1.07682098922975	H3-3A/H3-3B/H4C3/H2AZ2/H2AZ1/MACROH2A1/H2AJ/H2AC20/SSB/C1S/H3C4/C7/SNRPD1/H4C5/H2BC12/CD28/H2AC17/H2AC6	0.336784614463934
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/1096	69/9376	1.11583624246271	PDE3B/CALM1/GNAQ/PLCB1/CREB1/PPP3CC/PPP3CA/PPP3CB/ITPR1	0.351349950409957
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/1096	94/9376	1.09209504581457	MAPK8/TRAF3/S100A8/TNFAIP3/CXCL8/IL17RA/NFKB1/GSK3B/CXCL2/USP25/TAB2/MAPK14	0.326478931126538
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1096	37/9376	1.15604655750641	HBB/GNAQ/PRKCA/PRKCB/PLCB1	0.346003596851525
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1096	37/9376	1.15604655750641	LEF1/BRAF/TCF7/GADD45A/MAP2K1	0.346003596851525
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1096	62/9376	1.10383800329644	MAML2/MAML3/PSEN1/CIR1/KAT2B/ATXN1/CREBBP/HDAC1	0.298441904873218
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1096	21/9376	1.22210636079249	CSGALNACT1/CHST11/CSGALNACT2	0.370701629097624
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1096	21/9376	1.22210636079249	DPYD/PPCS/VNN2	0.370701629097624
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/1096	89/9376	1.05732797506766	GNAQ/PRKCA/MAP3K2/PRKCB/PLCB1/SOS1/MAP2K5/SOS2/ITPR1/RAF1/MAP2K1	0.197696795297273
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1096	47/9376	1.09209504581457	MAPK8/PRKCE/SOCS3/PIK3R1/PIK3CD/PIK3CB	0.230273200736176
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1096	98/9376	1.04751973782214	CAMK4/CAMK1D/CALM1/GNAQ/PRKCA/PRKCE/CAMK2D/PRKCB/PLCB1/CREB1/ATP2B1/ITPR1	0.172042457105862
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1096	56/9376	1.06934306569343	RAB1A/CXCL8/NFKB1/CYCS/CXCL2/BNIP3/HBS1L	0.189349796339811
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1096	31/9376	1.10383800329644	ACO2/PCCA/MDH1/DLD	0.210679980466151
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	20/1096	168/9376	1.01842196732708	H2AZ2/H2AZ1/MACROH2A1/STAT4/BCL2/MAPK8/H2AJ/STAT1/H2AC20/TNFAIP3/CAMK2D/JAK1/STAT5B/VPS4B/CHMP2A/JAK3/EIF2AK2/VDAC1/H2AC17/H2AC6	0.0876564221403934
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1096	23/9376	1.11583624246271	PDSS2/NUS1/PDSS1	0.202352539451051
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1096	49/9376	1.04751973782214	OGT/ST6GAL1/B4GALT1/GALNT11/GALNT2/B3GLCT	0.121332412906418
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1096	32/9376	1.06934306569343	BCL2/MAPK8/BIRC6/CYCS	0.142951053165372
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/1096	110/9376	1.01101526211015	DCN/EMP3/TGFBR2/RBX1/NCOR1/THBS1/RBL1/CREBBP/CUL1/SMAD2/HDAC1/ACVR2A/LEMD3	0.0422786174711556
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1096	76/9376	1.01306185170957	CALM1/GNAQ/PRKCA/ACTG1/ACTB/CAMK2D/PRKCB/PLCB1/ITPR1	0.0415954491004787
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1096	50/9376	1.02656934306569	HBB/CXCL8/THBS1/KLRC4-KLRK1/PECAM1/KLRB1	0.0685320716053898
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1096	33/9376	1.03693873036939	OGDH/ACO2/BCKDHB/DLD	0.0773341838443248
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/1096	155/9376	0.9934542029668	RAP1B/RAP1A/LEF1/GNAQ/BRAF/CDK6/TCF7/CAMK2D/PLCB1/CREB1/PDE8A/CDKN1B/RB1/GSK3B/ITPR1/WNT5A/AIP/MAP2K1	-0.0298961400886783
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1096	181/9376	0.99253942009114	BCL2/MAPK8/STAT1/CALM1/MALT1/CAMK2D/JAK1/CREB1/PPP3CC/CORO1A/RAB7A/NFKB1/PPP3CA/PPP3CB/CYCS/CREBBP/PIK3C3/RAF1/CTSS/MAPK14/EEA1	-0.0368732785272642
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/1096	103/9376	0.996669265112324	GNAQ/PRKCA/CXCL8/PRKCB/PLCB1/RAB7A/NFKB1/PIK3R1/CXCL2/PIK3CD/COL3A1/PIK3CB	-0.0123658591483078
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/1096	157/9376	0.980798735413083	ELMO1/ATP8A1/VPS8/RAC1/ATP11B/NFATC2/CAMK2D/GPR132/UQCRFS1/CREB1/THBS1/RAB7A/HIF1A/PECAM1/SIRPG/MAP2K1/VPS41/MAPK14	-0.0882700754261372
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/1096	157/9376	0.980798735413083	AREG/LEF1/CCND3/ACTG1/TGFBR2/ACTB/YWHAB/TCF7/FBXW11/DLG1/BTRC/PPP1CA/PPP1CB/PPP2R2D/PATJ/GSK3B/SMAD2/WNT5A	-0.0882700754261372
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1096	16/9376	1.06934306569343	ST3GAL1/ABO	0.10099522753824
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1096	52/9376	0.987085906793936	TSPO/VAPA/LIPC/LDLRAP1/NPC1/VDAC1	-0.0339734931158132
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	17/1096	149/9376	0.976044677411454	FYN/PIK3R5/PRKCA/CYTH1/CXCL8/PLCB1/SOS1/SOS2/PIK3R1/RALA/AGPAT3/PIK3CD/RAF1/GAB2/DNM2/MAP2K1/PIK3CB	-0.107236009457519
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1096	115/9376	0.967058076801016	GNG2/GNAQ/SLC18A2/PRKCA/BRAF/GNB1/GNB5/GNG5/PRKCB/PLCB1/ITPR1/RAF1/MAP2K1	-0.129313740828057
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1096	71/9376	0.963914876118022	SLC16A3/PDK1/PIK3R1/HIF1A/PIK3CD/RAF1/MAP2K1/PIK3CB	-0.111038844333472
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1096	26/9376	0.987085906793936	CUBN/LMBRD1/BTD	-0.023989463304675
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1096	89/9376	0.961207250061511	PLCL1/GNG2/PRKCA/GNB1/GNB5/GNG5/SLC38A1/PRKCB/GABARAPL2/GPHN	-0.133777659764821
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1096	17/9376	1.00644053241735	CA6/CA5B	0.00966957206524285
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/1096	116/9376	0.958721369242386	GNG2/GNAQ/PRKCA/GNB1/GNB5/GNG5/SLC38A1/PRKCB/PLCB1/PPP3CC/PPP3CA/PPP3CB/ITPR1	-0.162751324321629
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1096	72/9376	0.950527169505272	RNF125/MAPK8/TRAF3/CXCL8/TANK/ATG5/NFKB1/MAPK14	-0.153311206947101
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1096	36/9376	0.950527169505272	ST3GAL1/GCNT4/GALNT11/GALNT2	-0.108198270185692
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1096	36/9376	0.950527169505272	RNASEH2B/PRIM2/RPA3/RFC1	-0.108198270185692
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/1096	144/9376	0.950527169505272	IGF1R/JARID2/KAT6A/TCF7/JAK1/PIK3R1/JAK3/GSK3B/PIK3CD/RAF1/SMAD2/WNT5A/ACVR2A/MAP2K1/MAPK14/PIK3CB	-0.217658611033453
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1096	144/9376	0.950527169505272	MAPK8/MAP2K4/LEF1/TRAF3/FOXO1/TCF7/CXCL8/MAP3K5/IL17RA/NFKB1/GSK3B/CXCL2/TAB2/PRKAA1/MAPK14/ADH5	-0.217658611033453
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1096	27/9376	0.950527169505272	SCP2/HSD17B12/HACD4	-0.0936573375065664
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/1096	180/9376	0.950527169505272	SRSF5/BCL2/STAT1/TRAF3/PDIA3/JAK1/SP100/POU2F1/PPP1CA/SRSF4/PPP1CB/SOCS3/NFKB1/CYCS/PIK3R1/EIF2AK2/PIK3CD/TAB2/EIF2B3/PIK3CB	-0.243825585941494
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1096	28/9376	0.916579770594369	PTS/GPHN/PCBD2	-0.160829899482389
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1096	102/9376	0.922570488049234	RAB11A/RAP1B/RAP1A/GNAQ/PRKCA/RAC1/PRKCB/PLCB1/ATP2B1/ITPR1/RAB8A	-0.286054516253607
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1096	75/9376	0.912506082725061	GNAQ/PRKCA/PRKCB/PLCB1/GPX1/CREB1/TG/ITPR1	-0.276770257355521
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1096	48/9376	0.891119221411192	PRKCB/PLCB1/PIK3R1/PIK3CD/PIK3CB	-0.275139734989781
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1096	30/9376	0.855474452554745	NFKB1/MTR/ABCC4	-0.288448383195013
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/1096	78/9376	0.877409694927943	MAPK8/CALM1/CFL1/CXCL8/C1S/NFKB1/NOD1/MAPK14	-0.395534529905094
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/1096	78/9376	0.877409694927943	STAT1/CYBA/JAK1/PRKCB/ITGA4/NFKB1/TAB2/MAPK14	-0.395534529905094
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1096	50/9376	0.855474452554745	CXCR4/ICOS/CCR9/ITGA4/CD28	-0.372784345545802
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1096	10/9376	0.855474452554745	BPNT2	-0.166357847829358
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1096	51/9376	0.838700443681122	PLAAT2/PAFAH1B1/CHPT1/SELENOI/AGPS	-0.42021310021164
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/1096	155/9376	0.883070402637156	ATP6V1G1/ATP6V0E1/SEC61G/CYBA/ACTG1/ACTB/SEC61B/RAC1/THBS1/CORO1A/RAB7A/STX12/PIK3C3/CTSS/VAMP3/EEA1	-0.53404399885027
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1096	23/9376	0.743890828308473	RPA3/RFC1	-0.447393148868487
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1096	23/9376	0.743890828308473	ATP6AP2/PRCP	-0.447393148868487
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/1096	83/9376	0.824553689209392	POLR2L/SAMHD1/NFKB1/POLR3GL/POLR2K/POLR1C/POLR2F/POLR3B	-0.584091740439534
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/1096	54/9376	0.792105974587726	MTAP/AHCYL2/MTR/KYAT3/MDH1	-0.55739117191682
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1096	54/9376	0.792105974587726	REV3L/WDR48/RPA3/ATR/BRCA1	-0.55739117191682
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/1096	44/9376	0.77770404777704	ADPRS/RFC1/POLB/PARP4	-0.537707723705804
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1096	44/9376	0.77770404777704	RAB11A/ARHGDIB/DCTN4/CREB1	-0.537707723705804
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1096	12/9376	0.712895377128954	NPC1	-0.362056086542128
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1096	55/9376	0.77770404777704	CERS6/SGMS1/CERS5/SPTLC1/SPTLC2	-0.601530139414986
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1096	45/9376	0.760421735604217	ABCD3/ABCA5/ABCB7/ABCC4	-0.586091365746518
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1096	24/9376	0.712895377128954	EXT1/HS2ST1	-0.512353024302099
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1096	66/9376	0.77770404777704	IL21R/STAT4/STAT1/NFKB1/IL4R/SMAD2	-0.659332416878736
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/1096	86/9376	0.795790188423018	LEF1/ACTG1/ACTB/TCF7/SNTB1/SGCE/CACNB2/ITGA4	-0.692139635828916
NA	NA	hsa04518	Integrin signaling	15/1096	154/9376	0.833254336903972	IGF1R/CCND3/ACTG1/RAC2/ACTB/RAC1/ITGA4/THBS1/NCK2/PIK3R1/ARHGEF6/GSK3B/PIK3CD/PXN/PIK3CB	-0.7590634770268
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/1096	116/9376	0.811225773974327	OGDH/SUCLG2/SUCLA2/ACO2/PCCA/PGK1/SDHB/MDH1/DLD/ESD/ADH5	-0.74428959293428
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/1096	47/9376	0.728063363876378	ACYP2/MDH1/DLD/ADH5	-0.679946668615588
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1096	59/9376	0.724978349622665	PDE3B/PLAAT2/PIK3R1/PIK3CD/PIK3CB	-0.770957768367564
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1096	15/9376	0.570316301703163	ST3GAL1	-0.605911410448768
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1096	39/9376	0.658057271195957	AHCYL2/MTR/DLD	-0.778498435555074
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	21/1096	217/9376	0.827878502472333	BCL2/CCND3/PRKCA/PRKCB/SOS1/ESR2/STAT5B/RPS6KA3/CREB1/SOS2/NFKB1/RB1/PIK3R1/PIK3CD/RAF1/KPNA6/AIP/ESR1/MGST1/MAP2K1/PIK3CB	-0.93329018864135
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/1096	160/9376	0.802007299270073	CD6/SELL/CD2/GLG1/CD8B/SELPLG/CD99/ICOS/NLGN4X/ITGA4/VCAN/CD8A/CD4/PECAM1/CD28	-0.918996134962162
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/1096	28/9376	0.611053180396246	HSD17B12/HACD4	-0.749869406336638
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1096	28/9376	0.611053180396246	B4GALT1/ABO	-0.749869406336638
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1096	28/9376	0.611053180396246	ATP6V1G1/ATP6V0E1	-0.749869406336638
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/1096	61/9376	0.701208567667823	MT2A/ATP2B1/MT1X/SLC31A1/MT1F	-0.851760262603243
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/1096	112/9376	0.763816475495308	PIK3R5/BCL2/MAPK8/STAT1/JAK1/NFKB1/CYCS/PPIF/TAB2/MAPK14	-0.914818806741323
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1096	82/9376	0.73028306925405	DPYD/RRM1/NME7/CMPK1/HPRT1/MGST1/NME3	-0.89246161889196
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1096	83/9376	0.721484478058218	PEX14/PRDX5/FAR1/ABCD3/GSTK1/SCP2/AGPS	-0.927227339334339
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1096	29/9376	0.589982381072238	CALM1/GNB1	-0.804527963476159
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/1096	63/9376	0.678947978218051	LEF1/TCF7/GADD45A/GSK3B/WNT5A	-0.930200629981914
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1096	17/9376	0.503220266208673	SCP2	-0.74584632529907
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1096	30/9376	0.570316301703163	PIGU/PIGP	-0.857575496165643
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/1096	65/9376	0.658057271195957	GNAQ/PLCB1/CREB1/PDE8A/ITPR1	-1.00643941133869
NA	NA	hsa04981	Folate transport and metabolism	2/1096	31/9376	0.551919001648222	MTR/ABCC4	-0.909124722963914
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1096	18/9376	0.475263584752636	ACSF3	-0.810702818844201
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1096	18/9376	0.475263584752636	MANBA	-0.810702818844201
NA	NA	hsa04382	Cornified envelope formation	20/1096	217/9376	0.788455716640318	S100A6/KRT6A/KRT24/S100A4/KRT10/S100A10/SPRR3/S100A8/KRT17/PPP2R5C/KRT14/KRT5/PPP2R2D/S100A16/PPP2R3C/PPP2R5A/PPP2R3A/SPTLC1/S100A12/SPTLC2	-1.14705139659282
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/1096	88/9376	0.68049104180491	A2M/C1S/CLU/C7/PLAUR/SERPINB2/SERPIND1	-1.0955671930108
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1096	99/9376	0.691292486912925	ACTG1/ACTB/SNTB1/SGCE/CACNB2/ITGA4/TPM4/PRKAA1	-1.12340606712291
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1096	19/9376	0.450249711870918	HGSNAT	-0.872669300528028
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1096	79/9376	0.649727432320059	ATP6V1G1/SLC18A2/ATP6V0E1/AP2B1/CLTB/DNM2	-1.13742823041342
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1096	57/9376	0.600332949161224	SCP2/HSD17B12/HACD4/ACSF3	-1.10110025873516
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1096	20/9376	0.427737226277372	CYP2R1	-0.932054126757177
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1096	20/9376	0.427737226277372	GMDS	-0.932054126757177
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/1096	70/9376	0.611053180396246	MAPK8/PRKCQ/SOCS3/NFKB1/PRKAA1	-1.18832016651637
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1096	59/9376	0.579982679698132	RRM1/GPX1/GSTK1/MGST1	-1.17741863410161
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1096	254/9376	0.774642220817288	CAMK4/CXCR4/CAMK1D/CALM1/GNAQ/PRKCA/STIM1/ITPKB/NFATC2/CAMK2D/PRKCB/PLCB1/MCU/PPP3CC/ATP2B1/PHKB/PPP3CA/PPP3CB/ITPR1/PPIF/VDAC1/CYSLTR1/STIM2	-1.32470789742741
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1096	35/9376	0.488842544316997	GMDS/PMM2	-1.10221871996289
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/1096	82/9376	0.625956916503472	CD8B/PDIA3/CREB1/CD8A/CD4/CTSS	-1.23766459491222
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/1096	93/9376	0.643905501922926	CALM1/GNAQ/PRKCA/PRKCB/PLCB1/ATP2B1/ITPR1	-1.25556242303734
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/1096	104/9376	0.658057271195957	GPCPD1/PLAAT2/SGMS1/CHKA/CHPT1/SELENOI/TAFAZZIN/AGPAT3	-1.27573090982343
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1096	48/9376	0.534671532846715	VPS4B/CD9/TSG101	-1.17587652104571
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1096	49/9376	0.523759868911068	SLC18A2/CREB1/NFKB1	-1.21598659580508
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/1096	37/9376	0.462418623002565	GMDS/PMM2	-1.19198457828117
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1096	23/9376	0.371945414154237	B4GALT1	-1.09713883718803
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1096	23/9376	0.371945414154237	MDH1	-1.09713883718803
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1096	86/9376	0.596842641317264	GNAQ/PRKCA/CAMK2D/PRKCB/PLCB1/CREB1	-1.36644358694404
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1096	63/9376	0.543158382574441	PLAAT2/PTGDS/CBR3/TBXAS1	-1.32363084951956
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/1096	38/9376	0.450249711870918	NT5C2/NT5E	-1.23539567346828
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1096	39/9376	0.438704847463972	CD28/GZMB	-1.27789644675953
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/1096	100/9376	0.598832116788321	CXCR4/CXCL8/CCR9/CXCL14/IL24/CXCL2/XCL2	-1.46730883925407
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/1096	154/9376	0.666603469523178	ADSS2/EPRS1/AK5/PTS/NME7/TPK1/CMPK1/GPHN/PPCS/PMM2/NME3/DLD	-1.5176954227989
NA	NA	hsa04519	Cadherin signaling	37/1096	404/9376	0.783479077834791	KRT6A/MAPK8/KRT24/EVL/ARPC5/IGF1R/ARPC3/VAV1/LEF1/KRT10/CYFIP2/ACTG1/RAC2/ARPC2/KRT17/BRK1/ACTB/ACTR3/YWHAB/KRT14/RAC1/TCF7/KRT5/TMC8/TAOK3/PPP1CA/PSEN1/PPP1CB/NFKB1/RERE/CREBBP/GSK3B/RAF1/WNT5A/VAV3/MAP2K1/MAPK14	-1.61853339684213
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1096	54/9376	0.475263584752636	TG/CD28/GZMB	-1.40688721026079
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1096	26/9376	0.329028635597979	PLAAT2	-1.24640907169942
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1096	79/9376	0.541439526933383	HSD11B1/GSTK1/CBR3/MGST1/ADH5	-1.48906787326347
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1096	42/9376	0.407368786930831	KYAT3/DLD	-1.40039649541675
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/1096	42/9376	0.407368786930831	ATG7/ATG5	-1.40039649541675
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1096	27/9376	0.316842389835091	OXCT1	-1.29329011955789
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/1096	105/9376	0.570316301703163	ACTG1/ACTB/SNTB1/SGCE/CACNB2/ITGA4/TPM4	-1.61085327074135
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1096	44/9376	0.38885202388852	CD28/GZMB	-1.47829496577028
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/1096	29/9376	0.294991190536119	PAK1	-1.38335348416005
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/1096	194/9376	0.661449318985627	DYNLT1/MYL12A/CAPZA1/MYL12B/MYL6/ACTG1/DCTN4/ACTB/CAPZB/KIF2A/KIFAP3/ACTR10/DCTN3/MYL9/TPM4	-1.73353118763993
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1096	45/9376	0.380210867802109	CD28/GZMB	-1.51621875999827
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1096	30/9376	0.285158150851581	PLAAT2	-1.42670260913627
NA	NA	hsa04081	Hormone signaling	17/1096	219/9376	0.664066926640669	IGF1R/OPRM1/GNG2/GNAQ/GNB1/GNB5/GNG5/PLCB1/ESR2/STAT5B/PRL/PIK3R1/PIK3CD/ESR1/CSHL1/PIK3CB/RAMP1	-1.83009637343931
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1096	31/9376	0.275959500824111	DPYD	-1.46902707467895
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1096	99/9376	0.518469365184694	KRT24/KRT10/KRT17/SELPLG/KRT14/C1S	-1.75232028287073
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/1096	32/9376	0.267335766423358	B4GALT1	-1.51039073278677
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1096	66/9376	0.38885202388852	HSD11B1/HSD17B12/HSD17B11	-1.81267210729945
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/1096	67/9376	0.383048262337945	PGK1/DLD/ADH5	-1.8437958148244
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1096	95/9376	0.450249711870918	ATP6V1G1/ATP6V0E1/CXCL8/CXCL2/CD28	-1.95932116046318
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/1096	37/9376	0.231209311501282	ADSS2	-1.7046473033254
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1096	37/9376	0.231209311501282	ADH5	-1.7046473033254
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/1096	38/9376	0.225124855935459	PMM2	-1.74129494995494
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1096	70/9376	0.366631908237748	HSD11B1/GSTK1/MGST1	-1.93508222290093
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1096	73/9376	0.351564843515648	GSTK1/MGST1/ADH5	-2.02344879924579
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1096	41/9376	0.208652305501157	DLD	-1.84747195963971
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/1096	75/9376	0.342189781021898	ACO2/MTR/PGK1	-2.08085669573523
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	22/1096	298/9376	0.631558320677999	IL32/IL21R/CXCR4/RELL1/TGFBR2/TNFSF8/CXCL8/IL7R/CCR9/CD27/PRL/CXCL14/IL17RA/IL24/CD4/IL4R/CXCL2/IL3RA/XCL2/ACVR2A/CSHL1/OSM	-2.35156800607644
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/1096	233/9376	0.587450267848752	DCN/CAPZA1/ACTG1/ACTB/CAPZB/SNTB1/SGCE/ITGA4/ANKRD23/THBS1/VCAN/TMOD3/MYL9/TPM4/COL3A1/MYOM1	-2.3199875644214
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/1096	43/9376	0.198947547105755	ADH5	-1.91540358687115
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1096	46/9376	0.185972707077118	EPRS1	-2.01350543916693
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/1096	65/9376	0.263222908478383	LIPC/AGPAT3	-2.16855467251006
NA	NA	hsa04082	Neuroactive ligand signaling	12/1096	199/9376	0.515863991490298	OPRM1/GNG2/GNAQ/SLC18A2/PRKCA/GNB1/GNB5/GNG5/PRKCB/PLCB1/TAC3/TAC4	-2.5114197458094
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1096	323/9376	0.609161374884183	ZEB1/BCL2/PRKCA/RPS6KA5/HDAC4/RPTOR/PDCD4/CDK6/PRKCE/PRKCB/SOS1/THBS1/CDKN1B/SOS2/NFKB1/PIK3R1/CREBBP/PIK3CD/RAF1/HDAC1/MAP2K1/BRCA1/PIK3CB	-2.60062794370803
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1096	68/9376	0.251610133104337	ALDH1A2/ADH5	-2.25335654303297
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/1096	50/9376	0.171094890510949	P4HA3	-2.13805001415057
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/1096	52/9376	0.164514317798989	IGF1R	-2.19793729375348
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/1096	76/9376	0.225124855935459	DBI/SCP2	-2.4675888481078
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/1096	103/9376	0.249167316278081	PRCP/COL3A1/COL10A1	-2.78758037609194
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/1096	89/9376	0.192241450012302	ITGA4/THBS1	-2.78557330026157
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/1096	183/9376	0.373977902756172	XRN1/CSNK2A1/NOP10/POP5/WDR75/IMP3/RPP30/SBDS	-3.11144640659111
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1096	86/9376	0.0994737735528773	PLCB1	-3.05220346473184
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/1096	90/9376	0.0950527169505272	ABCC4	-3.13838299836885
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/1096	370/9376	0.300572104951667	P2RY8/TSPO/OPRM1/NR3C1/GZMA/PGRMC2/PRL/P2RY10/TAC3/CYSLTR1/CSHL1/UTS2/TAC4	-4.99405805619554
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1096	449/9376	0.0762115325215808	CALM1/GNB1/CAMK2D/NCALD	-7.2982491645502