ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 76/2068 175/18639 0.434285714285714 3.91424150317767 7.49029563718962e-28 8.89847121698127e-25 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 27/2068 68/18639 0.397058823529412 3.57871344862897 1.00113916109452e-09 5.79316572175776e-07 GO:0004812 aminoacyl-tRNA ligase activity 20/2068 41/18639 0.48780487804878 4.39661272821626 1.95056084907669e-09 5.79316572175776e-07 GO:0016875 ligase activity, forming carbon-oxygen bonds 20/2068 41/18639 0.48780487804878 4.39661272821626 1.95056084907669e-09 5.79316572175776e-07 GO:0015078 proton transmembrane transporter activity 49/2068 185/18639 0.264864864864865 2.38724188405039 4.11539358114233e-09 9.77817514879418e-07 GO:0003712 transcription coregulator activity 98/2068 495/18639 0.197979797979798 1.78440302444171 6.88994808143279e-09 1.36420972012369e-06 GO:0005085 guanyl-nucleotide exchange factor activity 53/2068 230/18639 0.230434782608696 2.07692162139433 1.58565117417973e-07 2.58470123717077e-05 GO:0019787 ubiquitin-like protein transferase activity 91/2068 479/18639 0.189979123173278 1.71229249362994 1.74053955365035e-07 2.58470123717077e-05 GO:0009055 electron transfer activity 33/2068 116/18639 0.28448275862069 2.56405906089508 2.25659416409948e-07 2.82810812766086e-05 GO:0016755 aminoacyltransferase activity 93/2068 496/18639 0.1875 1.68994801740812 2.38056239702092e-07 2.82810812766086e-05 GO:0003713 transcription coactivator activity 56/2068 256/18639 0.21875 1.97160602030948 4.47591292203836e-07 4.83398595580143e-05 GO:0008137 NADH dehydrogenase (ubiquinone) activity 17/2068 41/18639 0.414634146341463 3.73712081898382 6.0570835445459e-07 5.99651270910044e-05 GO:0016874 ligase activity 41/2068 167/18639 0.245508982035928 2.21278622638668 6.79701965650744e-07 6.21143027071603e-05 GO:0031492 nucleosomal DNA binding 17/2068 42/18639 0.404761904761905 3.64814175186516 9.12655831322029e-07 7.74453662578979e-05 GO:0030695 GTPase regulator activity 89/2068 489/18639 0.18200408997955 1.64041307211259 1.59786169228454e-06 0.000126550646028935 GO:0060589 nucleoside-triphosphatase regulator activity 89/2068 490/18639 0.181632653061225 1.63706529033277 1.74461618192119e-06 0.000129537751507648 GO:0004842 ubiquitin-protein transferase activity 83/2068 449/18639 0.184855233853007 1.66611059177282 1.89247506078412e-06 0.000130607337119542 GO:0003954 NADH dehydrogenase activity 17/2068 44/18639 0.386363636363636 3.48231712678038 1.97889904726579e-06 0.000130607337119542 GO:0031625 ubiquitin protein ligase binding 61/2068 302/18639 0.201986754966887 1.82051795252796 2.40895711099691e-06 0.000150623213045491 GO:0031491 nucleosome binding 23/2068 74/18639 0.310810810810811 2.80135527209995 2.85329750510353e-06 0.000169485871803149 GO:0022853 active monoatomic ion transmembrane transporter activity 31/2068 118/18639 0.26271186440678 2.36783677015376 3.35515158071136e-06 0.000189805717994528 GO:0019902 phosphatase binding 43/2068 190/18639 0.226315789473684 2.03979690522244 3.72935488900468e-06 0.000201385164006253 GO:0003743 translation initiation factor activity 18/2068 51/18639 0.352941176470588 3.18107862100353 4.56068212745721e-06 0.000235569146409529 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/2068 15/18639 0.6 5.407833655706 6.70814811325231e-06 0.000332053331605989 GO:0106310 protein serine kinase activity 68/2068 361/18639 0.188365650969529 1.69775017815331 8.22330196458454e-06 0.000390771309357057 GO:0044389 ubiquitin-like protein ligase binding 62/2068 322/18639 0.192546583850932 1.73543316073381 9.99626648551358e-06 0.00045675248403039 GO:0034450 ubiquitin-ubiquitin ligase activity 9/2068 16/18639 0.5625 5.06984405222437 1.38179645446803e-05 0.000607990439965933 GO:0004674 protein serine/threonine kinase activity 77/2068 433/18639 0.177829099307159 1.60278364699523 1.85538667029832e-05 0.000787214058683717 GO:0051020 GTPase binding 60/2068 315/18639 0.19047619047619 1.71677258911301 1.93714087157065e-05 0.000793559777733082 GO:0019208 phosphatase regulator activity 29/2068 117/18639 0.247863247863248 2.23400535634578 2.29421999967896e-05 0.000908511119872868 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 18/2068 58/18639 0.310344827586207 2.79715533915827 3.43664936539915e-05 0.00131701272454651 GO:0045309 protein phosphorylated amino acid binding 18/2068 59/18639 0.305084745762712 2.74974592663017 4.43693866975772e-05 0.00157399944818494 GO:0070063 RNA polymerase binding 18/2068 59/18639 0.305084745762712 2.74974592663017 4.43693866975772e-05 0.00157399944818494 GO:1990948 ubiquitin ligase inhibitor activity 7/2068 11/18639 0.636363636363636 5.73558114999121 4.50929046516764e-05 0.00157399944818494 GO:0043021 ribonucleoprotein complex binding 38/2068 177/18639 0.214689265536723 1.93500639281382 4.63720376148762e-05 0.00157399944818494 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 9/2068 18/18639 0.5 4.50652804642166 4.77136878253442e-05 0.00157455169823636 GO:0019843 rRNA binding 19/2068 65/18639 0.292307692307692 2.63458562713882 5.31557734186144e-05 0.00168439933424036 GO:0051219 phosphoprotein binding 24/2068 93/18639 0.258064516129032 2.32594995944344 5.6548305782839e-05 0.00168439933424036 GO:0001098 basal transcription machinery binding 18/2068 60/18639 0.3 2.703916827853 5.68706957070325e-05 0.00168439933424036 GO:0001099 basal RNA polymerase II transcription machinery binding 18/2068 60/18639 0.3 2.703916827853 5.68706957070325e-05 0.00168439933424036 GO:0015399 primary active transmembrane transporter activity 36/2068 166/18639 0.216867469879518 1.95463867073711 5.81316268550966e-05 0.00168439933424036 GO:0000993 RNA polymerase II complex binding 13/2068 36/18639 0.361111111111111 3.25471470019342 7.30546935554054e-05 0.00201834827776329 GO:0055106 ubiquitin-protein transferase regulator activity 13/2068 36/18639 0.361111111111111 3.25471470019342 7.30546935554054e-05 0.00201834827776329 GO:0035403 histone H3T6 kinase activity 48/2068 247/18639 0.194331983805668 1.75152507067401 7.58091262069035e-05 0.00202111375252975 GO:0061659 ubiquitin-like protein ligase activity 66/2068 372/18639 0.17741935483871 1.59909059711736 7.65573391109754e-05 0.00202111375252975 GO:0019888 protein phosphatase regulator activity 26/2068 107/18639 0.242990654205607 2.19008839639184 8.51485788804864e-05 0.00219905460239169 GO:0019903 protein phosphatase binding 32/2068 144/18639 0.222222222222222 2.00290135396518 8.98939204030103e-05 0.00227221228593141 GO:0019210 kinase inhibitor activity 23/2068 90/18639 0.255555555555556 2.30333655705996 9.41943834474848e-05 0.00233131099032525 GO:0140101 catalytic activity, acting on a tRNA 31/2068 139/18639 0.223021582733813 2.01010603509455 0.000107129258259855 0.00259733793495321 GO:0140996 histone H3 kinase activity 63/2068 357/18639 0.176470588235294 1.59053931050176 0.00012895068685609 0.0030638683197007 GO:0140297 DNA-binding transcription factor binding 81/2068 488/18639 0.165983606557377 1.49601955639408 0.00013375173363677 0.00311562861883299 GO:0140857 histone H3T45 kinase activity 47/2068 246/18639 0.191056910569106 1.7220066518847 0.00013671360660536 0.0031233800893686 GO:0035173 histone kinase activity 63/2068 360/18639 0.175 1.57728481624758 0.000164387390421827 0.00368475886454963 GO:0043130 ubiquitin binding 24/2068 100/18639 0.24 2.1631334622824 0.000192298068861795 0.00395724650379772 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 46/2068 243/18639 0.189300411522634 1.70617522745182 0.000199774802857014 0.00395724650379772 GO:0004676 3-phosphoinositide-dependent protein kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0004711 ribosomal protein S6 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0035175 histone H3S10 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0035979 histone H2AXS139 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0044022 histone H3S28 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0044023 histone H4S1 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0044024 histone H2AS1 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0044025 histone H2BS14 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0072354 histone H3T3 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0072371 histone H2AS121 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0072518 Rho-dependent protein serine/threonine kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0140823 histone H2BS36 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0140855 histone H3S57 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0140995 histone H2A kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0140997 histone H4 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0140998 histone H2B kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:1990244 histone H2AT120 kinase activity 46/2068 245/18639 0.187755102040816 1.6922472664114 0.000242561790956631 0.00395724650379772 GO:0061631 ubiquitin conjugating enzyme activity 12/2068 35/18639 0.342857142857143 3.09019066040343 0.000243164137017873 0.00395724650379772 GO:0032182 ubiquitin-like protein binding 27/2068 120/18639 0.225 2.02793762088975 0.000248816445725796 0.00399451266921954 GO:0004677 DNA-dependent protein kinase activity 46/2068 246/18639 0.186991869918699 1.6853682124829 0.000266906873357423 0.00422780487398159 GO:0035402 histone H3T11 kinase activity 46/2068 247/18639 0.186234817813765 1.67854485939592 0.000293426837723034 0.00452769701869625 GO:0061630 ubiquitin protein ligase activity 61/2068 353/18639 0.172804532577904 1.55749694522222 0.000293461843804387 0.00452769701869625 GO:0031490 chromatin DNA binding 28/2068 128/18639 0.21875 1.97160602030948 0.000317020236771692 0.00475517078285293 GO:0141003 histone H2AX kinase activity 61/2068 354/18639 0.172316384180791 1.55309723633741 0.000317024109243863 0.00475517078285293 GO:0004679 AMP-activated protein kinase activity 46/2068 248/18639 0.185483870967742 1.67177653334997 0.000322289623177607 0.00475517078285293 GO:0061650 ubiquitin-like protein conjugating enzyme activity 13/2068 41/18639 0.317073170731707 2.85779827334057 0.000327469611269361 0.00475517078285293 GO:0044390 ubiquitin-like protein conjugating enzyme binding 12/2068 36/18639 0.333333333333333 3.00435203094778 0.000328218858749108 0.00475517078285293 GO:0045296 cadherin binding 58/2068 334/18639 0.173652694610778 1.56514147720034 0.000358868355396275 0.00513657356880451 GO:0140098 catalytic activity, acting on RNA 65/2068 387/18639 0.167958656330749 1.51382079078764 0.000424782770939559 0.0059619883770032 GO:0043175 RNA polymerase core enzyme binding 13/2068 42/18639 0.30952380952381 2.78975545730865 0.00042657324246235 0.0059619883770032 GO:0019207 kinase regulator activity 51/2068 287/18639 0.177700348432056 1.60162320813592 0.000456632381206728 0.00630789847527434 GO:0003714 transcription corepressor activity 39/2068 204/18639 0.191176470588235 1.72308425304358 0.000479578438130801 0.00654872625861369 GO:0070990 snRNP binding 6/2068 11/18639 0.545454545454545 4.91621241427818 0.000521421691290557 0.00703919283242252 GO:0004129 cytochrome-c oxidase activity 7/2068 15/18639 0.466666666666667 4.20609284332689 0.000587582793092431 0.00767086107905283 GO:0031386 protein tag activity 7/2068 15/18639 0.466666666666667 4.20609284332689 0.000587582793092431 0.00767086107905283 GO:0141047 molecular tag activity 7/2068 15/18639 0.466666666666667 4.20609284332689 0.000587582793092431 0.00767086107905283 GO:0035091 phosphatidylinositol binding 50/2068 284/18639 0.176056338028169 1.58680565014847 0.000641829672666289 0.00826245921819569 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 59/2068 349/18639 0.169054441260745 1.52369716182738 0.000646808676171885 0.00826245921819569 GO:0004860 protein kinase inhibitor activity 20/2068 84/18639 0.238095238095238 2.14596573639127 0.0007094879867638 0.00896672051356802 GO:0016675 oxidoreductase activity, acting on a heme group of donors 7/2068 16/18639 0.4375 3.94321204061896 0.000944915632168813 0.0118164186422795 GO:0019211 phosphatase activator activity 9/2068 25/18639 0.36 3.2447001934236 0.000973480263604835 0.0120468182621098 GO:0016922 nuclear receptor binding 28/2068 137/18639 0.204379562043796 1.84208445693148 0.000992114712022015 0.0121508482255892 GO:0072542 protein phosphatase activator activity 8/2068 21/18639 0.380952380952381 3.43354517822603 0.00121739265679952 0.0147577803701819 GO:0017022 myosin binding 18/2068 76/18639 0.236842105263158 2.13467117988395 0.00136931973921657 0.0164318368705989 GO:0003727 single-stranded RNA binding 20/2068 89/18639 0.224719101123595 2.0254058635603 0.00152623946433451 0.0181317248362939 GO:0008135 translation factor activity, RNA binding 19/2068 83/18639 0.228915662650602 2.06322970800028 0.00157239660806582 0.0184951204988337 GO:0031994 insulin-like growth factor I binding 6/2068 13/18639 0.461538461538462 4.15987204285077 0.00159081196529811 0.0185282805370015 GO:0015252 proton channel activity 9/2068 27/18639 0.333333333333333 3.00435203094778 0.00181917359000479 0.0206929496960737 GO:0180051 translation factor activity 19/2068 84/18639 0.226190476190476 2.0386674495717 0.00182463143583103 0.0206929496960737 GO:0031267 small GTPase binding 48/2068 283/18639 0.169611307420495 1.52871622776141 0.00182892232162268 0.0206929496960737 GO:0048156 tau protein binding 12/2068 43/18639 0.27906976744186 2.51527146777023 0.00192722204683931 0.0215994319966519 GO:0071889 14-3-3 protein binding 10/2068 33/18639 0.303030303030303 2.73122911904343 0.00231346093216748 0.0256859026861212 GO:0140030 modification-dependent protein binding 32/2068 173/18639 0.184971098265896 1.66715488422536 0.00254694379663519 0.0280163817629871 GO:0005520 insulin-like growth factor binding 7/2068 19/18639 0.368421052631579 3.3205996131528 0.00308443212594664 0.0333118669602237 GO:0050145 nucleoside monophosphate kinase activity 7/2068 19/18639 0.368421052631579 3.3205996131528 0.00308443212594664 0.0333118669602237 GO:0016651 oxidoreductase activity, acting on NAD(P)H 19/2068 88/18639 0.215909090909091 1.94600074731845 0.00320175572813975 0.0342674396849552 GO:0030276 clathrin binding 12/2068 46/18639 0.260869565217391 2.35123202422 0.00357263162794166 0.0375953269544174 GO:0017124 SH3 domain binding 23/2068 115/18639 0.2 1.80261121856867 0.00357598648640502 0.0375953269544174 GO:0031624 ubiquitin conjugating enzyme binding 9/2068 30/18639 0.3 2.703916827853 0.00408753046393322 0.0425963700978304 GO:0015631 tubulin binding 60/2068 385/18639 0.155844155844156 1.40463211836519 0.00416302093408767 0.0430058162582274 GO:0001784 phosphotyrosine residue binding 12/2068 47/18639 0.25531914893617 2.30120581093872 0.00432226339158065 0.0437583414262898 GO:0008526 phosphatidylinositol transfer activity 5/2068 11/18639 0.454545454545455 4.09684367856515 0.00434636724604562 0.0437583414262898 GO:0032050 clathrin heavy chain binding 5/2068 11/18639 0.454545454545455 4.09684367856515 0.00434636724604562 0.0437583414262898 GO:0005246 calcium channel regulator activity 13/2068 53/18639 0.245283018867925 2.21074960767855 0.0044116756341164 0.0440426105321873 GO:0048487 beta-tubulin binding 11/2068 42/18639 0.261904761904762 2.3605623100304 0.00501767506439037 0.0496749831374647 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 7/2068 21/18639 0.333333333333333 3.00435203094778 0.00583546286600515 0.057293635411687 GO:1990841 promoter-specific chromatin binding 15/2068 68/18639 0.220588235294118 1.9881741381272 0.00674598943128744 0.0645054854202398 GO:0035197 siRNA binding 5/2068 12/18639 0.416666666666667 3.75544003868472 0.00677589817929961 0.0645054854202398 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 5/2068 12/18639 0.416666666666667 3.75544003868472 0.00677589817929961 0.0645054854202398 GO:0005496 steroid binding 21/2068 108/18639 0.194444444444444 1.75253868471954 0.00728334178872897 0.0645054854202398 GO:0001046 core promoter sequence-specific DNA binding 11/2068 44/18639 0.25 2.25326402321083 0.00731116292694451 0.0645054854202398 GO:0019205 nucleobase-containing compound kinase activity 11/2068 44/18639 0.25 2.25326402321083 0.00731116292694451 0.0645054854202398 GO:0003725 double-stranded RNA binding 16/2068 75/18639 0.213333333333333 1.92278529980658 0.00734325407090994 0.0645054854202398 GO:0035591 signaling adaptor activity 24/2068 129/18639 0.186046511627907 1.67684764518015 0.00762222709427799 0.0645054854202398 GO:0032931 histone H3K56 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0043992 histone H3K9 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0043993 histone H3K18 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0043994 histone H3K23 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0043999 histone H2AK5 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044012 histone H2AK9 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044014 histone H2BK5 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044015 histone H2BK12 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044016 histone H3K4 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044017 histone H3K27 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0044018 histone H3K36 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0046972 histone H4K16 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0140908 histone H3K122 acetyltransferase activity 7/2068 22/18639 0.318181818181818 2.8677905749956 0.00775199424845483 0.0645054854202398 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 6/2068 17/18639 0.352941176470588 3.18107862100353 0.00776454917095479 0.0645054854202398 GO:0051536 iron-sulfur cluster binding 16/2068 76/18639 0.210526315789474 1.89748549323017 0.0083673445907661 0.0690305928738204 GO:0016776 phosphotransferase activity, phosphate group as acceptor 10/2068 39/18639 0.256410256410256 2.31104002380598 0.00857791634687831 0.0702797560006306 GO:0036408 histone H3K14 acetyltransferase activity 8/2068 28/18639 0.285714285714286 2.57515888366952 0.00918075709594725 0.0741955063264309 GO:0046966 nuclear thyroid hormone receptor binding 8/2068 28/18639 0.285714285714286 2.57515888366952 0.00918075709594725 0.0741955063264309 GO:0046982 protein heterodimerization activity 56/2068 369/18639 0.151761517615176 1.36783507100061 0.00940598610725942 0.0752632958149704 GO:0051540 metal cluster binding 16/2068 77/18639 0.207792207792208 1.87284282448693 0.0095022177268867 0.0752632958149704 GO:0019887 protein kinase regulator activity 41/2068 255/18639 0.16078431372549 1.44915803845716 0.00950294139077909 0.0752632958149704 GO:0044013 histone H2B acetyltransferase activity 7/2068 23/18639 0.304347826086957 2.74310402825666 0.0100954909802471 0.0788251515699038 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 7/2068 23/18639 0.304347826086957 2.74310402825666 0.0100954909802471 0.0788251515699038 GO:0030159 signaling receptor complex adaptor activity 12/2068 52/18639 0.230769230769231 2.07993602142538 0.0101517240658209 0.0788251515699038 GO:0030291 protein serine/threonine kinase inhibitor activity 11/2068 46/18639 0.239130434782609 2.15529602220167 0.0103484718716655 0.0798310687242765 GO:0008525 phosphatidylcholine transporter activity 6/2068 18/18639 0.333333333333333 3.00435203094778 0.0105707205869484 0.080500102931376 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 6/2068 18/18639 0.333333333333333 3.00435203094778 0.0105707205869484 0.080500102931376 GO:0005543 phospholipid binding 72/2068 497/18639 0.144869215291751 1.30571436355074 0.0108300478318935 0.081949661301207 GO:0043022 ribosome binding 21/2068 112/18639 0.1875 1.68994801740812 0.0110191386317914 0.0828527638896718 GO:0031593 polyubiquitin modification-dependent protein binding 13/2068 59/18639 0.220338983050847 1.98592761367734 0.0113366158491658 0.0847037712503706 GO:0010484 histone H3 acetyltransferase activity 8/2068 29/18639 0.275862068965517 2.48636030147402 0.0114711475903269 0.085173270858177 GO:0140566 histone reader activity 9/2068 35/18639 0.257142857142857 2.31764299530257 0.0121450951793847 0.0896172240565781 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7/2068 24/18639 0.291666666666667 2.6288080270793 0.0129150817594657 0.0929885886681529 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 7/2068 24/18639 0.291666666666667 2.6288080270793 0.0129150817594657 0.0929885886681529 GO:0043998 histone H2A acetyltransferase activity 7/2068 24/18639 0.291666666666667 2.6288080270793 0.0129150817594657 0.0929885886681529 GO:0048027 mRNA 5'-UTR binding 7/2068 24/18639 0.291666666666667 2.6288080270793 0.0129150817594657 0.0929885886681529 GO:0000287 magnesium ion binding 37/2068 230/18639 0.160869565217391 1.44992641493567 0.0131189513676173 0.0938874350887309 GO:0043995 histone H4K5 acetyltransferase activity 8/2068 30/18639 0.266666666666667 2.40348162475822 0.0141560992726518 0.0985074053267763 GO:0043996 histone H4K8 acetyltransferase activity 8/2068 30/18639 0.266666666666667 2.40348162475822 0.0141560992726518 0.0985074053267763 GO:0043997 histone H4K12 acetyltransferase activity 8/2068 30/18639 0.266666666666667 2.40348162475822 0.0141560992726518 0.0985074053267763 GO:0019992 diacylglycerol binding 5/2068 14/18639 0.357142857142857 3.2189486045869 0.0141790962212784 0.0985074053267763 GO:0034236 protein kinase A catalytic subunit binding 5/2068 14/18639 0.357142857142857 3.2189486045869 0.0141790962212784 0.0985074053267763 GO:0042393 histone binding 39/2068 247/18639 0.157894736842105 1.42311411992263 0.0148516187256428 0.102579785151533 GO:0032934 sterol binding 14/2068 68/18639 0.205882352941176 1.85562919558539 0.0158866608381228 0.109094526449075 GO:0019003 GDP binding 15/2068 75/18639 0.2 1.80261121856867 0.016603466643053 0.113361599838775 GO:1990782 protein tyrosine kinase binding 21/2068 117/18639 0.179487179487179 1.61772801666419 0.0176918846425733 0.120102622602155 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/2068 10/18639 0.4 3.60522243713733 0.0182999047536473 0.122826479363463 GO:0050815 phosphoserine residue binding 4/2068 10/18639 0.4 3.60522243713733 0.0182999047536473 0.122826479363463 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/2068 15/18639 0.333333333333333 3.00435203094778 0.0193611364477481 0.127783500555137 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/2068 15/18639 0.333333333333333 3.00435203094778 0.0193611364477481 0.127783500555137 GO:0042809 nuclear vitamin D receptor binding 5/2068 15/18639 0.333333333333333 3.00435203094778 0.0193611364477481 0.127783500555137 GO:0016248 channel inhibitor activity 10/2068 44/18639 0.227272727272727 2.04842183928257 0.0201144196704428 0.129525415463255 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/2068 26/18639 0.269230769230769 2.42659202499628 0.0201702035864496 0.129525415463255 GO:0043548 phosphatidylinositol 3-kinase binding 7/2068 26/18639 0.269230769230769 2.42659202499628 0.0201702035864496 0.129525415463255 GO:0052742 phosphatidylinositol kinase activity 7/2068 26/18639 0.269230769230769 2.42659202499628 0.0201702035864496 0.129525415463255 GO:0120014 phospholipid transfer activity 7/2068 26/18639 0.269230769230769 2.42659202499628 0.0201702035864496 0.129525415463255 GO:0051059 NF-kappaB binding 8/2068 32/18639 0.25 2.25326402321083 0.0208479903276576 0.1331581317702 GO:0019783 ubiquitin-like protein peptidase activity 22/2068 127/18639 0.173228346456693 1.56131680348467 0.0226316314983278 0.143560597801524 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6/2068 21/18639 0.285714285714286 2.57515888366952 0.0231400124675804 0.143560597801524 GO:0035613 RNA stem-loop binding 6/2068 21/18639 0.285714285714286 2.57515888366952 0.0231400124675804 0.143560597801524 GO:0051010 microtubule plus-end binding 6/2068 21/18639 0.285714285714286 2.57515888366952 0.0231400124675804 0.143560597801524 GO:0004715 non-membrane spanning protein tyrosine kinase activity 10/2068 45/18639 0.222222222222222 2.00290135396518 0.0233676360768076 0.143560597801524 GO:0051539 4 iron, 4 sulfur cluster binding 10/2068 45/18639 0.222222222222222 2.00290135396518 0.0233676360768076 0.143560597801524 GO:0141110 transporter inhibitor activity 10/2068 45/18639 0.222222222222222 2.00290135396518 0.0233676360768076 0.143560597801524 GO:0000149 SNARE binding 19/2068 106/18639 0.179245283018868 1.61554779022663 0.0235382866090357 0.143560597801524 GO:0061980 regulatory RNA binding 12/2068 58/18639 0.206896551724138 1.86477022610552 0.0236107833992636 0.143560597801524 GO:0043178 alcohol binding 17/2068 92/18639 0.184782608695652 1.66545601715583 0.0236850817921707 0.143560597801524 GO:0005096 GTPase activator activity 41/2068 271/18639 0.151291512915129 1.36359889227519 0.0245822606716051 0.146673856355144 GO:0120013 lipid transfer activity 13/2068 65/18639 0.2 1.80261121856867 0.024676511451859 0.146673856355144 GO:0008266 poly(U) RNA binding 7/2068 27/18639 0.259259259259259 2.33671824629271 0.0246925684099569 0.146673856355144 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7/2068 27/18639 0.259259259259259 2.33671824629271 0.0246925684099569 0.146673856355144 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/2068 16/18639 0.3125 2.81658002901354 0.0256448003557966 0.148614745476519 GO:0004708 MAP kinase kinase activity 5/2068 16/18639 0.3125 2.81658002901354 0.0256448003557966 0.148614745476519 GO:0017070 U6 snRNA binding 5/2068 16/18639 0.3125 2.81658002901354 0.0256448003557966 0.148614745476519 GO:0043023 ribosomal large subunit binding 5/2068 16/18639 0.3125 2.81658002901354 0.0256448003557966 0.148614745476519 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 5/2068 16/18639 0.3125 2.81658002901354 0.0256448003557966 0.148614745476519 GO:0002162 dystroglycan binding 4/2068 11/18639 0.363636363636364 3.27747494285212 0.0262733547579911 0.14863212120235 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/2068 11/18639 0.363636363636364 3.27747494285212 0.0262733547579911 0.14863212120235 GO:0034056 estrogen response element binding 4/2068 11/18639 0.363636363636364 3.27747494285212 0.0262733547579911 0.14863212120235 GO:0042608 T cell receptor binding 4/2068 11/18639 0.363636363636364 3.27747494285212 0.0262733547579911 0.14863212120235 GO:0050786 RAGE receptor binding 4/2068 11/18639 0.363636363636364 3.27747494285212 0.0262733547579911 0.14863212120235 GO:0000049 tRNA binding 15/2068 80/18639 0.1875 1.68994801740812 0.0286510111693436 0.159007856148639 GO:0048306 calcium-dependent protein binding 15/2068 80/18639 0.1875 1.68994801740812 0.0286510111693436 0.159007856148639 GO:0004857 enzyme inhibitor activity 59/2068 416/18639 0.141826923076923 1.27829401316768 0.0286622622160505 0.159007856148639 GO:0016251 RNA polymerase II general transcription initiation factor activity 11/2068 53/18639 0.207547169811321 1.87063428342031 0.0288681483931904 0.159007856148639 GO:0050321 tau-protein kinase activity 6/2068 22/18639 0.272727272727273 2.45810620713909 0.0289105192997525 0.159007856148639 GO:0140035 ubiquitin-like protein reader activity 6/2068 22/18639 0.272727272727273 2.45810620713909 0.0289105192997525 0.159007856148639 GO:0052866 phosphatidylinositol phosphate phosphatase activity 8/2068 34/18639 0.235294117647059 2.12071908066902 0.0295164776262035 0.161592513455898 GO:0015485 cholesterol binding 11/2068 54/18639 0.203703703703704 1.83599290780142 0.0327439627188888 0.177102464681005 GO:0140463 chromatin-protein adaptor activity 11/2068 54/18639 0.203703703703704 1.83599290780142 0.0327439627188888 0.177102464681005 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/2068 41/18639 0.219512195121951 1.97847572769732 0.0329771962483746 0.177102464681005 GO:0140318 protein transporter activity 9/2068 41/18639 0.219512195121951 1.97847572769732 0.0329771962483746 0.177102464681005 GO:0051787 misfolded protein binding 5/2068 17/18639 0.294117647058824 2.65089885083627 0.0330949050161474 0.177102464681005 GO:0010485 histone H4 acetyltransferase activity 8/2068 35/18639 0.228571428571429 2.06012710693562 0.0346635539067424 0.184665031574933 GO:0043236 laminin binding 7/2068 29/18639 0.241379310344828 2.17556526378977 0.0357151800056919 0.187694011667702 GO:0005049 nuclear export signal receptor activity 4/2068 12/18639 0.333333333333333 3.00435203094778 0.0360220830473368 0.187694011667702 GO:0016273 arginine N-methyltransferase activity 4/2068 12/18639 0.333333333333333 3.00435203094778 0.0360220830473368 0.187694011667702 GO:0016274 protein-arginine N-methyltransferase activity 4/2068 12/18639 0.333333333333333 3.00435203094778 0.0360220830473368 0.187694011667702 GO:0097371 MDM2/MDM4 family protein binding 4/2068 12/18639 0.333333333333333 3.00435203094778 0.0360220830473368 0.187694011667702 GO:0004402 histone acetyltransferase activity 9/2068 42/18639 0.214285714285714 1.93136916275214 0.0379843918016938 0.196197641132227 GO:0035198 miRNA binding 9/2068 42/18639 0.214285714285714 1.93136916275214 0.0379843918016938 0.196197641132227 GO:0001222 transcription corepressor binding 10/2068 49/18639 0.204081632653061 1.83939920262109 0.0401942866609569 0.20671347425635 GO:0008170 N-methyltransferase activity 17/2068 98/18639 0.173469387755102 1.56348932222792 0.0409145063574822 0.20861130280124 GO:0030527 structural constituent of chromatin 17/2068 98/18639 0.173469387755102 1.56348932222792 0.0409145063574822 0.20861130280124 GO:0070064 proline-rich region binding 5/2068 18/18639 0.277777777777778 2.50362669245648 0.0417580528735317 0.21191834412979 GO:0001968 fibronectin binding 7/2068 30/18639 0.233333333333333 2.10304642166344 0.0422766393592258 0.21191834412979 GO:0008187 poly-pyrimidine tract binding 7/2068 30/18639 0.233333333333333 2.10304642166344 0.0422766393592258 0.21191834412979 GO:0031210 phosphatidylcholine binding 7/2068 30/18639 0.233333333333333 2.10304642166344 0.0422766393592258 0.21191834412979 GO:0008200 ion channel inhibitor activity 9/2068 43/18639 0.209302325581395 1.88645360082767 0.0434849279453371 0.216151022590211 GO:0008375 acetylglucosaminyltransferase activity 9/2068 43/18639 0.209302325581395 1.88645360082767 0.0434849279453371 0.216151022590211 GO:0003697 single-stranded DNA binding 20/2068 121/18639 0.165289256198347 1.48976133766005 0.0444591685487575 0.22007288431635 GO:0042578 phosphoric ester hydrolase activity 51/2068 363/18639 0.140495867768595 1.26629713701105 0.0455953455593359 0.224760458607847 GO:0016504 peptidase activator activity 11/2068 57/18639 0.192982456140351 1.73936170212766 0.0465500797211619 0.228518573176613 GO:0019855 calcium channel inhibitor activity 4/2068 13/18639 0.307692307692308 2.77324802856718 0.0475800857070196 0.231660417294833 GO:0140333 glycerophospholipid flippase activity 4/2068 13/18639 0.307692307692308 2.77324802856718 0.0475800857070196 0.231660417294833 GO:0004721 phosphoprotein phosphatase activity 27/2068 175/18639 0.154285714285714 1.39058579718154 0.0481066279721515 0.233268057269045 GO:0043014 alpha-tubulin binding 9/2068 44/18639 0.204545454545455 1.84357965535432 0.0494944872160242 0.239022157774946 GO:0016835 carbon-oxygen lyase activity 14/2068 79/18639 0.177215189873418 1.59725044683299 0.0512507915051465 0.245499640407107 GO:0017025 TBP-class protein binding 6/2068 25/18639 0.24 2.1631334622824 0.0515716720860168 0.245499640407107 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 6/2068 25/18639 0.24 2.1631334622824 0.0515716720860168 0.245499640407107 GO:0140036 ubiquitin-modified protein reader activity 5/2068 19/18639 0.263157894736842 2.37185686653772 0.0516623822405529 0.245499640407107 GO:0140767 enzyme-substrate adaptor activity 22/2068 139/18639 0.158273381294964 1.42652686361549 0.0548947415499369 0.259165926067343 GO:1901981 phosphatidylinositol phosphate binding 28/2068 185/18639 0.151351351351351 1.36413821945737 0.0549745903779212 0.259165926067343 GO:0022884 macromolecule transmembrane transporter activity 7/2068 32/18639 0.21875 1.97160602030948 0.0576122754150919 0.269462138555627 GO:0140142 nucleocytoplasmic carrier activity 7/2068 32/18639 0.21875 1.97160602030948 0.0576122754150919 0.269462138555627 GO:0008276 protein methyltransferase activity 16/2068 95/18639 0.168421052631579 1.51798839458414 0.0581726616198793 0.271016164723202 GO:0005545 1-phosphatidylinositol binding 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:0032036 myosin heavy chain binding 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:0042043 neurexin family protein binding 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:0046030 inositol trisphosphate phosphatase activity 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:0071933 Arp2/3 complex binding 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:1990825 sequence-specific mRNA binding 4/2068 14/18639 0.285714285714286 2.57515888366952 0.0609404815013161 0.275305046766087 GO:0050681 nuclear androgen receptor binding 6/2068 26/18639 0.230769230769231 2.07993602142538 0.0609921126358869 0.275305046766087 GO:0050750 low-density lipoprotein particle receptor binding 6/2068 26/18639 0.230769230769231 2.07993602142538 0.0609921126358869 0.275305046766087 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2068 39/18639 0.205128205128205 1.84883201904478 0.0611788992813526 0.275305046766087 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/2068 20/18639 0.25 2.25326402321083 0.062817891174551 0.280555092914912 GO:0016505 peptidase activator activity involved in apoptotic process 5/2068 20/18639 0.25 2.25326402321083 0.062817891174551 0.280555092914912 GO:0042826 histone deacetylase binding 20/2068 127/18639 0.15748031496063 1.41937891225879 0.0675961907520783 0.300765073458686 GO:0030331 nuclear estrogen receptor binding 8/2068 40/18639 0.2 1.80261121856867 0.0693623034674229 0.30450246625152 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2068 40/18639 0.2 1.80261121856867 0.0693623034674229 0.30450246625152 GO:0050997 quaternary ammonium group binding 8/2068 40/18639 0.2 1.80261121856867 0.0693623034674229 0.30450246625152 GO:0005548 phospholipid transporter activity 12/2068 68/18639 0.176470588235294 1.59053931050176 0.069461421173537 0.30450246625152 GO:0019905 syntaxin binding 11/2068 61/18639 0.180327868852459 1.62530519707011 0.070457534636301 0.305373404784122 GO:0061733 protein-lysine-acetyltransferase activity 9/2068 47/18639 0.191489361702128 1.72590435820404 0.0706950241068674 0.305373404784122 GO:0140938 histone H3 methyltransferase activity 9/2068 47/18639 0.191489361702128 1.72590435820404 0.0706950241068674 0.305373404784122 GO:1990518 single-stranded 3'-5' DNA helicase activity 9/2068 47/18639 0.191489361702128 1.72590435820404 0.0706950241068674 0.305373404784122 GO:0003925 G protein activity 10/2068 54/18639 0.185185185185185 1.66908446163765 0.070945336464998 0.305373404784122 GO:0008320 protein transmembrane transporter activity 6/2068 27/18639 0.222222222222222 2.00290135396518 0.0713634109861527 0.306064015348554 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 20/2068 128/18639 0.15625 1.40829001450677 0.0721289983277846 0.307547638137226 GO:0030165 PDZ domain binding 14/2068 83/18639 0.168674698795181 1.52027452168442 0.0722270968352576 0.307547638137226 GO:0002020 protease binding 21/2068 136/18639 0.154411764705882 1.39172189668904 0.0737224675476161 0.311680752478889 GO:0140789 histone phosphatase activity 21/2068 136/18639 0.154411764705882 1.39172189668904 0.0737224675476161 0.311680752478889 GO:0050700 CARD domain binding 4/2068 15/18639 0.266666666666667 2.40348162475822 0.0760602433389771 0.320424003853563 GO:0099106 ion channel regulator activity 24/2068 160/18639 0.15 1.3519584139265 0.0772792847324417 0.324409152869755 GO:0016247 channel regulator activity 25/2068 168/18639 0.148809523809524 1.34122858524454 0.0781284468782672 0.324983501628894 GO:0017080 sodium channel regulator activity 8/2068 41/18639 0.195121951219512 1.7586450912865 0.0781829355205254 0.324983501628894 GO:0051117 ATPase binding 14/2068 84/18639 0.166666666666667 1.50217601547389 0.0782367689106597 0.324983501628894 GO:0043138 3'-5' DNA helicase activity 9/2068 48/18639 0.1875 1.68994801740812 0.0788445200303447 0.325233645125172 GO:0140693 molecular condensate scaffold activity 9/2068 48/18639 0.1875 1.68994801740812 0.0788445200303447 0.325233645125172 GO:0051537 2 iron, 2 sulfur cluster binding 6/2068 28/18639 0.214285714285714 1.93136916275214 0.0826816579329325 0.339881694201812 GO:0141108 transporter regulator activity 25/2068 170/18639 0.147058823529412 1.32544942541814 0.0869549136546107 0.352612660404098 GO:0016859 cis-trans isomerase activity 8/2068 42/18639 0.19047619047619 1.71677258911301 0.0876414163955448 0.352612660404098 GO:0034062 5'-3' RNA polymerase activity 5/2068 22/18639 0.227272727272727 2.04842183928257 0.0888368485559871 0.352612660404098 GO:0097747 RNA polymerase activity 5/2068 22/18639 0.227272727272727 2.04842183928257 0.0888368485559871 0.352612660404098 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0005131 growth hormone receptor binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0005522 profilin binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0008140 cAMP response element binding protein binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0031419 cobalamin binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0031996 thioesterase binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0051864 histone H3K36 demethylase activity 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0051880 G-quadruplex DNA binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0099122 RNA polymerase II C-terminal domain binding 3/2068 10/18639 0.3 2.703916827853 0.0902308491269745 0.352612660404098 GO:0000062 fatty-acyl-CoA binding 4/2068 16/18639 0.25 2.25326402321083 0.0928653910000373 0.357035872194318 GO:0015923 mannosidase activity 4/2068 16/18639 0.25 2.25326402321083 0.0928653910000373 0.357035872194318 GO:0097027 ubiquitin-protein transferase activator activity 4/2068 16/18639 0.25 2.25326402321083 0.0928653910000373 0.357035872194318 GO:0140327 flippase activity 4/2068 16/18639 0.25 2.25326402321083 0.0928653910000373 0.357035872194318 GO:0140328 floppase activity 4/2068 16/18639 0.25 2.25326402321083 0.0928653910000373 0.357035872194318 GO:0016410 N-acyltransferase activity 15/2068 94/18639 0.159574468085106 1.4382536318367 0.0943474008461476 0.361563587758785 GO:0003785 actin monomer binding 6/2068 29/18639 0.206896551724138 1.86477022610552 0.0949337826096038 0.362640944502281 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/2068 36/18639 0.194444444444444 1.75253868471954 0.0973942711185861 0.368485331493249 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/2068 36/18639 0.194444444444444 1.75253868471954 0.0973942711185861 0.368485331493249 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/2068 36/18639 0.194444444444444 1.75253868471954 0.0973942711185861 0.368485331493249 GO:0005158 insulin receptor binding 5/2068 23/18639 0.217391304347826 1.95936002018333 0.103638440507604 0.387177570198219 GO:0017134 fibroblast growth factor binding 5/2068 23/18639 0.217391304347826 1.95936002018333 0.103638440507604 0.387177570198219 GO:0070577 lysine-acetylated histone binding 5/2068 23/18639 0.217391304347826 1.95936002018333 0.103638440507604 0.387177570198219 GO:0140103 catalytic activity, acting on a glycoprotein 5/2068 23/18639 0.217391304347826 1.95936002018333 0.103638440507604 0.387177570198219 GO:0070566 adenylyltransferase activity 6/2068 30/18639 0.2 1.80261121856867 0.108098068422198 0.40257211688267 GO:0030971 receptor tyrosine kinase binding 13/2068 81/18639 0.160493827160494 1.44653986675263 0.109833997126923 0.405437104294483 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:0008429 phosphatidylethanolamine binding 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:0031489 myosin V binding 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:0032183 SUMO binding 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:1901567 fatty acid derivative binding 4/2068 17/18639 0.235294117647059 2.12071908066902 0.111256309764311 0.405437104294483 GO:0019206 nucleoside kinase activity 3/2068 11/18639 0.272727272727273 2.45810620713909 0.114214909515343 0.410352328820977 GO:0032404 mismatch repair complex binding 3/2068 11/18639 0.272727272727273 2.45810620713909 0.114214909515343 0.410352328820977 GO:0034511 U3 snoRNA binding 3/2068 11/18639 0.272727272727273 2.45810620713909 0.114214909515343 0.410352328820977 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/2068 11/18639 0.272727272727273 2.45810620713909 0.114214909515343 0.410352328820977 GO:0035064 methylated histone binding 12/2068 74/18639 0.162162162162162 1.46157666370432 0.114332172424026 0.410352328820977 GO:0016791 phosphatase activity 37/2068 273/18639 0.135531135531136 1.22154972686888 0.115749356522838 0.413040052168189 GO:0019838 growth factor binding 20/2068 136/18639 0.147058823529412 1.32544942541814 0.115776378259265 0.413040052168189 GO:0140104 molecular carrier activity 34/2068 249/18639 0.136546184738956 1.23069842231596 0.118150728755261 0.419025962862541 GO:0042054 histone methyltransferase activity 11/2068 67/18639 0.164179104477612 1.4797554779295 0.118871607840099 0.419025962862541 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2068 24/18639 0.208333333333333 1.87772001934236 0.119570539907745 0.419025962862541 GO:0030552 cAMP binding 5/2068 24/18639 0.208333333333333 1.87772001934236 0.119570539907745 0.419025962862541 GO:0070300 phosphatidic acid binding 5/2068 24/18639 0.208333333333333 1.87772001934236 0.119570539907745 0.419025962862541 GO:0140033 acetylation-dependent protein binding 5/2068 24/18639 0.208333333333333 1.87772001934236 0.119570539907745 0.419025962862541 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/2068 38/18639 0.184210526315789 1.6602998065764 0.121776346021783 0.423055402474231 GO:0042162 telomeric DNA binding 7/2068 38/18639 0.184210526315789 1.6602998065764 0.121776346021783 0.423055402474231 GO:0005164 tumor necrosis factor receptor binding 6/2068 31/18639 0.193548387096774 1.74446246958258 0.122144783710994 0.423055402474231 GO:0070325 lipoprotein particle receptor binding 6/2068 31/18639 0.193548387096774 1.74446246958258 0.122144783710994 0.423055402474231 GO:0034212 protein N-acetyltransferase activity 9/2068 53/18639 0.169811320754717 1.53051895916207 0.127728933671656 0.438560616190541 GO:0051018 protein kinase A binding 9/2068 53/18639 0.169811320754717 1.53051895916207 0.127728933671656 0.438560616190541 GO:0140296 general transcription initiation factor binding 9/2068 53/18639 0.169811320754717 1.53051895916207 0.127728933671656 0.438560616190541 GO:0140223 general transcription initiation factor activity 11/2068 68/18639 0.161764705882353 1.45799436795995 0.128406907021365 0.439617883404559 GO:0031690 adrenergic receptor binding 4/2068 18/18639 0.222222222222222 2.00290135396518 0.131112954590248 0.446310000152478 GO:1990381 ubiquitin-specific protease binding 4/2068 18/18639 0.222222222222222 2.00290135396518 0.131112954590248 0.446310000152478 GO:0140034 methylation-dependent protein binding 12/2068 76/18639 0.157894736842105 1.42311411992263 0.13230935805754 0.449095763921021 GO:0035401 histone H3Y41 kinase activity 17/2068 115/18639 0.147826086956522 1.33236481372467 0.133886854263325 0.451386300500197 GO:0140801 histone H2AXY142 kinase activity 17/2068 115/18639 0.147826086956522 1.33236481372467 0.133886854263325 0.451386300500197 GO:0008234 cysteine-type peptidase activity 26/2068 187/18639 0.13903743315508 1.25315218403169 0.134124043835496 0.451386300500197 GO:0003707 nuclear steroid receptor activity 5/2068 25/18639 0.2 1.80261121856867 0.136570256863178 0.453481444010969 GO:0004709 MAP kinase kinase kinase activity 5/2068 25/18639 0.2 1.80261121856867 0.136570256863178 0.453481444010969 GO:0030515 snoRNA binding 6/2068 32/18639 0.1875 1.68994801740812 0.137036901010049 0.453481444010969 GO:0031369 translation initiation factor binding 6/2068 32/18639 0.1875 1.68994801740812 0.137036901010049 0.453481444010969 GO:0070717 poly-purine tract binding 6/2068 32/18639 0.1875 1.68994801740812 0.137036901010049 0.453481444010969 GO:0120015 sterol transfer activity 6/2068 32/18639 0.1875 1.68994801740812 0.137036901010049 0.453481444010969 GO:0002039 p53 binding 11/2068 69/18639 0.159420289855072 1.43686401480111 0.138347956457176 0.455283579698406 GO:0016279 protein-lysine N-methyltransferase activity 11/2068 69/18639 0.159420289855072 1.43686401480111 0.138347956457176 0.455283579698406 GO:0005095 GTPase inhibitor activity 3/2068 12/18639 0.25 2.25326402321083 0.140279185004679 0.45657992270016 GO:0005165 neurotrophin receptor binding 3/2068 12/18639 0.25 2.25326402321083 0.140279185004679 0.45657992270016 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2068 12/18639 0.25 2.25326402321083 0.140279185004679 0.45657992270016 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/2068 12/18639 0.25 2.25326402321083 0.140279185004679 0.45657992270016 GO:0004713 protein tyrosine kinase activity 20/2068 140/18639 0.142857142857143 1.28757944183476 0.142589887062473 0.462832748169995 GO:0043495 protein-membrane adaptor activity 8/2068 47/18639 0.170212765957447 1.53413720729248 0.144246202849243 0.465664372241577 GO:0061749 forked DNA-dependent helicase activity 8/2068 47/18639 0.170212765957447 1.53413720729248 0.144246202849243 0.465664372241577 GO:0016278 lysine N-methyltransferase activity 11/2068 70/18639 0.157142857142857 1.41633738601824 0.148686119800653 0.478288739245437 GO:0004532 RNA exonuclease activity 7/2068 40/18639 0.175 1.57728481624758 0.148961981078124 0.478288739245437 GO:0120227 acyl-CoA binding 4/2068 19/18639 0.210526315789474 1.89748549323017 0.1522997738835 0.485396236775555 GO:1990380 K48-linked deubiquitinase activity 4/2068 19/18639 0.210526315789474 1.89748549323017 0.1522997738835 0.485396236775555 GO:0019956 chemokine binding 6/2068 33/18639 0.181818181818182 1.63873747142606 0.152730880342421 0.485396236775555 GO:0022804 active transmembrane transporter activity 58/2068 457/18639 0.12691466083151 1.14388895707858 0.152809926392304 0.485396236775555 GO:0003924 GTPase activity 43/2068 331/18639 0.129909365558912 1.17088039876817 0.15392019727634 0.487619184971445 GO:0009378 four-way junction helicase activity 8/2068 48/18639 0.166666666666667 1.50217601547389 0.157326539413022 0.495766389450055 GO:0036121 double-stranded DNA helicase activity 8/2068 48/18639 0.166666666666667 1.50217601547389 0.157326539413022 0.495766389450055 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 23/2068 167/18639 0.137724550898204 1.24131910260716 0.162235422109478 0.509882755201218 GO:0001727 lipid kinase activity 7/2068 41/18639 0.170731707317073 1.53881445487569 0.163534137516453 0.512072760290227 GO:0008081 phosphoric diester hydrolase activity 13/2068 87/18639 0.149425287356322 1.34677849663176 0.163794317264551 0.512072760290227 GO:0004722 protein serine/threonine phosphatase activity 15/2068 103/18639 0.145631067961165 1.31258098439466 0.165726306243756 0.515993877972207 GO:0002161 aminoacyl-tRNA editing activity 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0031432 titin binding 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0043560 insulin receptor substrate binding 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0046974 histone H3K9 methyltransferase activity 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0046975 histone H3K36 methyltransferase activity 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0140852 histone ubiquitin ligase activity 3/2068 13/18639 0.230769230769231 2.07993602142538 0.168088914793977 0.515993877972207 GO:0005518 collagen binding 11/2068 72/18639 0.152777777777778 1.37699468085106 0.170511606283947 0.522081928518888 GO:0008017 microtubule binding 36/2068 276/18639 0.130434782608696 1.17561601211 0.172266726906638 0.526099926902535 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 5/2068 27/18639 0.185185185185185 1.66908446163765 0.17347451722632 0.526670686645066 GO:0004197 cysteine-type endopeptidase activity 13/2068 88/18639 0.147727272727273 1.33147419553367 0.173911887822983 0.526670686645066 GO:0000339 RNA cap binding 4/2068 20/18639 0.2 1.80261121856867 0.174670244560737 0.526670686645066 GO:0016004 phospholipase activator activity 4/2068 20/18639 0.2 1.80261121856867 0.174670244560737 0.526670686645066 GO:0052745 inositol phosphate phosphatase activity 4/2068 20/18639 0.2 1.80261121856867 0.174670244560737 0.526670686645066 GO:0005319 lipid transporter activity 24/2068 178/18639 0.134831460674157 1.21524351813618 0.182439224509184 0.548703287890912 GO:0000175 3'-5'-RNA exonuclease activity 6/2068 35/18639 0.171428571428571 1.54509533020171 0.186322672196134 0.557560036697752 GO:0005154 epidermal growth factor receptor binding 6/2068 35/18639 0.171428571428571 1.54509533020171 0.186322672196134 0.557560036697752 GO:0008408 3'-5' exonuclease activity 9/2068 58/18639 0.155172413793103 1.39857766957914 0.189309827887335 0.563659337168305 GO:0017116 single-stranded DNA helicase activity 9/2068 58/18639 0.155172413793103 1.39857766957914 0.189309827887335 0.563659337168305 GO:0008168 methyltransferase activity 27/2068 204/18639 0.132352941176471 1.19290448287632 0.19098128943127 0.567214429610873 GO:0019789 SUMO transferase activity 5/2068 28/18639 0.178571428571429 1.60947430229345 0.193212095333578 0.570984998149978 GO:0097718 disordered domain specific binding 5/2068 28/18639 0.178571428571429 1.60947430229345 0.193212095333578 0.570984998149978 GO:0003678 DNA helicase activity 11/2068 74/18639 0.148648648648649 1.33977860839563 0.193784754608928 0.571256298946418 GO:0004705 JUN kinase activity 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0008174 mRNA methyltransferase activity 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0016530 metallochaperone activity 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0044548 S100 protein binding 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0061665 SUMO ligase activity 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0070742 C2H2 zinc finger domain binding 3/2068 14/18639 0.214285714285714 1.93136916275214 0.197311214782884 0.572526261995128 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2068 21/18639 0.19047619047619 1.71677258911301 0.198070954276092 0.572526261995128 GO:0140312 cargo adaptor activity 4/2068 21/18639 0.19047619047619 1.71677258911301 0.198070954276092 0.572526261995128 GO:0005048 signal sequence binding 8/2068 51/18639 0.156862745098039 1.41381272044601 0.199674177197848 0.575759520657873 GO:0001221 transcription coregulator binding 16/2068 115/18639 0.139130434782609 1.25399041291733 0.203332206268476 0.583475026683454 GO:0101005 deubiquitinase activity 16/2068 115/18639 0.139130434782609 1.25399041291733 0.203332206268476 0.583475026683454 GO:0005484 SNAP receptor activity 6/2068 36/18639 0.166666666666667 1.50217601547389 0.204108352411644 0.583803611631196 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 10/2068 67/18639 0.149253731343284 1.34523225266318 0.204920964688728 0.583803611631196 GO:0050840 extracellular matrix binding 10/2068 67/18639 0.149253731343284 1.34523225266318 0.204920964688728 0.583803611631196 GO:0016741 transferase activity, transferring one-carbon groups 28/2068 215/18639 0.130232558139535 1.17379335162611 0.209915227528592 0.596601172975998 GO:0001223 transcription coactivator binding 7/2068 44/18639 0.159090909090909 1.4338952874978 0.210729533831783 0.597486124563623 GO:0005516 calmodulin binding 27/2068 207/18639 0.130434782608696 1.17561601211 0.21261030260595 0.601383427371117 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/2068 29/18639 0.172413793103448 1.55397518842126 0.21368674381774 0.602992521746971 GO:0004843 cysteine-type deubiquitinase activity 15/2068 108/18639 0.138888888888889 1.25181334622824 0.21478247443291 0.604648292953309 GO:0008970 phospholipase A1 activity 4/2068 22/18639 0.181818181818182 1.63873747142606 0.222345199991671 0.618965571252033 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2068 22/18639 0.181818181818182 1.63873747142606 0.222345199991671 0.618965571252033 GO:0070034 telomerase RNA binding 4/2068 22/18639 0.181818181818182 1.63873747142606 0.222345199991671 0.618965571252033 GO:0019213 deacetylase activity 6/2068 37/18639 0.162162162162162 1.46157666370432 0.222473315593113 0.618965571252033 GO:0030551 cyclic nucleotide binding 6/2068 37/18639 0.162162162162162 1.46157666370432 0.222473315593113 0.618965571252033 GO:0004559 alpha-mannosidase activity 3/2068 15/18639 0.2 1.80261121856867 0.227623957643861 0.628877352746294 GO:0008252 nucleotidase activity 3/2068 15/18639 0.2 1.80261121856867 0.227623957643861 0.628877352746294 GO:0061578 K63-linked deubiquitinase activity 3/2068 15/18639 0.2 1.80261121856867 0.227623957643861 0.628877352746294 GO:0051087 protein-folding chaperone binding 18/2068 134/18639 0.134328358208955 1.21070902739686 0.228535271721594 0.629930168921704 GO:0004864 protein phosphatase inhibitor activity 8/2068 53/18639 0.150943396226415 1.36046129703296 0.230193005291359 0.632596481083706 GO:0015026 coreceptor activity 9/2068 61/18639 0.147540983606557 1.32979516123918 0.231416793044752 0.632596481083706 GO:0016836 hydro-lyase activity 9/2068 61/18639 0.147540983606557 1.32979516123918 0.231416793044752 0.632596481083706 GO:0008080 N-acetyltransferase activity 10/2068 69/18639 0.144927536231884 1.30624001345555 0.231632549891761 0.632596481083706 GO:0001965 G-protein alpha-subunit binding 5/2068 30/18639 0.166666666666667 1.50217601547389 0.234804478896848 0.638324304186397 GO:0051721 protein phosphatase 2A binding 5/2068 30/18639 0.166666666666667 1.50217601547389 0.234804478896848 0.638324304186397 GO:0097110 scaffold protein binding 10/2068 70/18639 0.142857142857143 1.28757944183476 0.245456954906945 0.664301957918254 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 8/2068 54/18639 0.148148148148148 1.33526756931012 0.246037762191946 0.664301957918254 GO:0017069 snRNA binding 8/2068 54/18639 0.148148148148148 1.33526756931012 0.246037762191946 0.664301957918254 GO:0004602 glutathione peroxidase activity 4/2068 23/18639 0.173913043478261 1.56748801614667 0.247336096725159 0.664785707940019 GO:0043274 phospholipase binding 4/2068 23/18639 0.173913043478261 1.56748801614667 0.247336096725159 0.664785707940019 GO:0016779 nucleotidyltransferase activity 18/2068 136/18639 0.132352941176471 1.19290448287632 0.248116794341643 0.665378671959079 GO:0004707 MAP kinase activity 3/2068 16/18639 0.1875 1.68994801740812 0.25872208840782 0.687610382614072 GO:0008142 oxysterol binding 3/2068 16/18639 0.1875 1.68994801740812 0.25872208840782 0.687610382614072 GO:0015562 efflux transmembrane transporter activity 3/2068 16/18639 0.1875 1.68994801740812 0.25872208840782 0.687610382614072 GO:0030275 LRR domain binding 3/2068 16/18639 0.1875 1.68994801740812 0.25872208840782 0.687610382614072 GO:0005504 fatty acid binding 7/2068 47/18639 0.148936170212766 1.34237005638092 0.262242135597321 0.695409948860752 GO:0004540 RNA nuclease activity 16/2068 121/18639 0.132231404958678 1.19180907012804 0.265588869397819 0.702716206780867 GO:0035035 histone acetyltransferase binding 4/2068 24/18639 0.166666666666667 1.50217601547389 0.272889208088642 0.71255288056015 GO:0060229 lipase activator activity 4/2068 24/18639 0.166666666666667 1.50217601547389 0.272889208088642 0.71255288056015 GO:0070840 dynein complex binding 4/2068 24/18639 0.166666666666667 1.50217601547389 0.272889208088642 0.71255288056015 GO:0005525 GTP binding 46/2068 378/18639 0.121693121693122 1.09682693193331 0.27341115114352 0.71255288056015 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 16/2068 122/18639 0.131147540983607 1.18204014332372 0.276592472279738 0.71255288056015 GO:0019212 phosphatase inhibitor activity 8/2068 56/18639 0.142857142857143 1.28757944183476 0.278715950671734 0.71255288056015 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 7/2068 48/18639 0.145833333333333 1.31440401353965 0.280154554458055 0.71255288056015 GO:0015036 disulfide oxidoreductase activity 6/2068 40/18639 0.15 1.3519584139265 0.280401136071569 0.71255288056015 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/2068 40/18639 0.15 1.3519584139265 0.280401136071569 0.71255288056015 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 12/2068 89/18639 0.134831460674157 1.21524351813618 0.280931004560678 0.71255288056015 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 12/2068 89/18639 0.134831460674157 1.21524351813618 0.280931004560678 0.71255288056015 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0140791 histone H2AXS140 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2068 81/18639 0.135802469135802 1.22399527186761 0.284763699498091 0.71255288056015 GO:0004725 protein tyrosine phosphatase activity 13/2068 98/18639 0.13265306122449 1.19560948170371 0.289636531433858 0.71255288056015 GO:0004550 nucleoside diphosphate kinase activity 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0004659 prenyltransferase activity 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0016018 cyclosporin A binding 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0032977 membrane insertase activity 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0036041 long-chain fatty acid binding 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0070492 oligosaccharide binding 3/2068 17/18639 0.176470588235294 1.59053931050176 0.290321898117143 0.71255288056015 GO:0140793 histone H2AXY142 phosphatase activity 12/2068 90/18639 0.133333333333333 1.20174081237911 0.294145599481144 0.71255288056015 GO:0004601 peroxidase activity 8/2068 57/18639 0.140350877192982 1.26499032882012 0.295473976273409 0.71255288056015 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/2068 82/18639 0.134146341463415 1.20906850025947 0.298716164202958 0.71255288056015 GO:0033549 MAP kinase phosphatase activity 11/2068 82/18639 0.134146341463415 1.20906850025947 0.298716164202958 0.71255288056015 GO:0017056 structural constituent of nuclear pore 4/2068 25/18639 0.16 1.44208897485493 0.298854722607778 0.71255288056015 GO:0120020 cholesterol transfer activity 4/2068 25/18639 0.16 1.44208897485493 0.298854722607778 0.71255288056015 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/2068 41/18639 0.146341463414634 1.31898381846488 0.300435478681018 0.71255288056015 GO:0042287 MHC protein binding 6/2068 41/18639 0.146341463414634 1.31898381846488 0.300435478681018 0.71255288056015 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2068 33/18639 0.151515151515152 1.36561455952172 0.301061318062584 0.71255288056015 GO:0140311 protein sequestering activity 5/2068 33/18639 0.151515151515152 1.36561455952172 0.301061318062584 0.71255288056015 GO:0019001 guanyl nucleotide binding 48/2068 400/18639 0.12 1.0815667311412 0.302596332698191 0.71255288056015 GO:0032561 guanyl ribonucleotide binding 48/2068 400/18639 0.12 1.0815667311412 0.302596332698191 0.71255288056015 GO:0003684 damaged DNA binding 10/2068 74/18639 0.135135135135135 1.21798055308694 0.303324018258344 0.71255288056015 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0005528 FK506 binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0019911 structural constituent of myelin sheath 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0030957 Tat protein binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0032356 oxidized DNA binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0033204 ribonuclease P RNA binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0045322 unmethylated CpG binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0070097 delta-catenin binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0070513 death domain binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0097177 mitochondrial ribosome binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0140940 histone H2A methyltransferase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0140999 histone H3K4 trimethyltransferase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:1905394 retromer complex binding 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:1990259 histone H2AQ104 methyltransferase activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:1990757 ubiquitin ligase activator activity 2/2068 10/18639 0.2 1.80261121856867 0.306493705358785 0.71255288056015 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/2068 83/18639 0.132530120481928 1.1945014098949 0.31284506790034 0.725898321612507 GO:0032813 tumor necrosis factor receptor superfamily binding 7/2068 50/18639 0.14 1.26182785299807 0.316798566987815 0.730068013364917 GO:0051879 Hsp90 protein binding 6/2068 42/18639 0.142857142857143 1.28757944183476 0.320722611504415 0.730068013364917 GO:0000400 four-way junction DNA binding 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0004706 JUN kinase kinase kinase activity 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0017075 syntaxin-1 binding 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0035615 clathrin adaptor activity 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0050811 GABA receptor binding 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:1901611 phosphatidylglycerol binding 3/2068 18/18639 0.166666666666667 1.50217601547389 0.322163686822522 0.730068013364917 GO:0008376 acetylgalactosaminyltransferase activity 5/2068 34/18639 0.147058823529412 1.32544942541814 0.323799908424654 0.730068013364917 GO:0015035 protein-disulfide reductase activity 5/2068 34/18639 0.147058823529412 1.32544942541814 0.323799908424654 0.730068013364917 GO:0030332 cyclin binding 5/2068 34/18639 0.147058823529412 1.32544942541814 0.323799908424654 0.730068013364917 GO:0008173 RNA methyltransferase activity 9/2068 67/18639 0.134328358208955 1.21070902739686 0.323912363174623 0.730068013364917 GO:0008143 poly(A) binding 4/2068 26/18639 0.153846153846154 1.38662401428359 0.325089207971415 0.730068013364917 GO:0008157 protein phosphatase 1 binding 4/2068 26/18639 0.153846153846154 1.38662401428359 0.325089207971415 0.730068013364917 GO:0034237 protein kinase A regulatory subunit binding 4/2068 26/18639 0.153846153846154 1.38662401428359 0.325089207971415 0.730068013364917 GO:0051139 metal cation:proton antiporter activity 4/2068 26/18639 0.153846153846154 1.38662401428359 0.325089207971415 0.730068013364917 GO:0004527 exonuclease activity 11/2068 84/18639 0.130952380952381 1.1802811550152 0.327128644098089 0.731881034253351 GO:0017018 myosin phosphatase activity 11/2068 84/18639 0.130952380952381 1.1802811550152 0.327128644098089 0.731881034253351 GO:0001786 phosphatidylserine binding 8/2068 59/18639 0.135593220338983 1.22210930072452 0.329636275486913 0.733348118498975 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/2068 59/18639 0.135593220338983 1.22210930072452 0.329636275486913 0.733348118498975 GO:0070888 E-box binding 8/2068 59/18639 0.135593220338983 1.22210930072452 0.329636275486913 0.733348118498975 GO:0030544 Hsp70 protein binding 7/2068 51/18639 0.137254901960784 1.23708613039026 0.335431992636219 0.744847116358558 GO:0004712 protein serine/threonine/tyrosine kinase activity 6/2068 43/18639 0.13953488372093 1.25763573388512 0.341197877250365 0.755694215061759 GO:0043015 gamma-tubulin binding 5/2068 35/18639 0.142857142857143 1.28757944183476 0.346712781129407 0.755694215061759 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/2068 60/18639 0.133333333333333 1.20174081237911 0.346963776370398 0.755694215061759 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0008172 S-methyltransferase activity 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0019107 myristoyltransferase activity 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0019215 intermediate filament binding 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0034713 type I transforming growth factor beta receptor binding 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0048185 activin binding 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0180030 inositol phosphate kinase activity 2/2068 11/18639 0.181818181818182 1.63873747142606 0.349222326657328 0.755694215061759 GO:0003756 protein disulfide isomerase activity 3/2068 19/18639 0.157894736842105 1.42311411992263 0.354013170498588 0.759147376448235 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/2068 19/18639 0.157894736842105 1.42311411992263 0.354013170498588 0.759147376448235 GO:0016918 retinal binding 3/2068 19/18639 0.157894736842105 1.42311411992263 0.354013170498588 0.759147376448235 GO:0042800 histone H3K4 methyltransferase activity 3/2068 19/18639 0.157894736842105 1.42311411992263 0.354013170498588 0.759147376448235 GO:0046624 sphingolipid transporter activity 3/2068 19/18639 0.157894736842105 1.42311411992263 0.354013170498588 0.759147376448235 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2068 36/18639 0.138888888888889 1.25181334622824 0.369713495438723 0.784663875887795 GO:0005544 calcium-dependent phospholipid binding 7/2068 53/18639 0.132075471698113 1.19040363490384 0.373080269606885 0.784663875887795 GO:0019209 kinase activator activity 18/2068 148/18639 0.121621621621622 1.09618249777824 0.376642475181957 0.784663875887795 GO:0046625 sphingolipid binding 4/2068 28/18639 0.142857142857143 1.28757944183476 0.377831127765131 0.784663875887795 GO:0046875 ephrin receptor binding 4/2068 28/18639 0.142857142857143 1.28757944183476 0.377831127765131 0.784663875887795 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2068 28/18639 0.142857142857143 1.28757944183476 0.377831127765131 0.784663875887795 GO:0141052 histone H3 demethylase activity 4/2068 28/18639 0.142857142857143 1.28757944183476 0.377831127765131 0.784663875887795 GO:0046332 SMAD binding 10/2068 79/18639 0.126582278481013 1.14089317630928 0.379542341811132 0.784663875887795 GO:0031072 heat shock protein binding 16/2068 131/18639 0.122137404580153 1.10083127851522 0.381132946394135 0.784663875887795 GO:0016408 C-acyltransferase activity 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0030742 GTP-dependent protein binding 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0042288 MHC class I protein binding 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0043024 ribosomal small subunit binding 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0061608 nuclear import signal receptor activity 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0140939 histone H4 methyltransferase activity 3/2068 20/18639 0.15 1.3519584139265 0.385661922134679 0.784663875887795 GO:0000340 RNA 7-methylguanosine cap binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0004300 enoyl-CoA hydratase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0004526 ribonuclease P activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0005025 transforming growth factor beta receptor activity, type I 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0005026 transforming growth factor beta receptor activity, type II 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0005527 macrolide binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0015132 prostaglandin transmembrane transporter activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0016208 AMP binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0016361 activin receptor activity, type I 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0016362 activin receptor activity, type II 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0017002 activin receptor activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0034452 dynactin binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0035497 cAMP response element binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0036009 protein-glutamine N-methyltransferase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0045295 gamma-catenin binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0070410 co-SMAD binding 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:1990817 poly(A) RNA polymerase activity 2/2068 12/18639 0.166666666666667 1.50217601547389 0.391010954987857 0.784663875887795 GO:0050661 NADP binding 7/2068 54/18639 0.12962962962963 1.16835912314636 0.392001494115493 0.785325084332555 GO:0008013 beta-catenin binding 13/2068 106/18639 0.122641509433962 1.10537480383928 0.394781457569652 0.789562915139304 GO:0019842 vitamin binding 18/2068 150/18639 0.12 1.0815667311412 0.399218485777439 0.796277331939836 GO:0005507 copper ion binding 8/2068 63/18639 0.126984126984127 1.14451505940868 0.399479200198773 0.796277331939836 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2068 46/18639 0.130434782608696 1.17561601211 0.403131329623048 0.801442310994485 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2068 29/18639 0.137931034482759 1.24318015073701 0.404094229196714 0.801442310994485 GO:0097472 cyclin-dependent protein kinase activity 4/2068 29/18639 0.137931034482759 1.24318015073701 0.404094229196714 0.801442310994485 GO:0140313 molecular sequestering activity 7/2068 55/18639 0.127272727272727 1.14711622999824 0.410927300034393 0.813636054068098 GO:0140597 protein carrier chaperone 22/2068 188/18639 0.117021276595745 1.05471933001358 0.429096416016259 0.834970969393247 GO:0032452 histone demethylase activity 4/2068 30/18639 0.133333333333333 1.20174081237911 0.430138806165924 0.834970969393247 GO:0098918 structural constituent of synapse 4/2068 30/18639 0.133333333333333 1.20174081237911 0.430138806165924 0.834970969393247 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0004535 poly(A)-specific ribonuclease activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0008253 5'-nucleotidase activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0039706 co-receptor binding 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0070123 transforming growth factor beta receptor activity, type III 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0071714 icosanoid transmembrane transporter activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0140666 annealing activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/2068 13/18639 0.153846153846154 1.38662401428359 0.431542235023109 0.834970969393247 GO:0044325 transmembrane transporter binding 16/2068 136/18639 0.117647058823529 1.06035954033451 0.441476085093097 0.852802583887153 GO:0032266 phosphatidylinositol-3-phosphate binding 6/2068 48/18639 0.125 1.12663201160542 0.444262789884372 0.854998135059543 GO:0004407 histone deacetylase activity 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0008649 rRNA methyltransferase activity 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0033558 protein lysine deacetylase activity 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0061133 endopeptidase activator activity 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0140517 protein-RNA adaptor activity 3/2068 22/18639 0.136363636363636 1.22905310356954 0.447650538726461 0.854998135059543 GO:0016878 acid-thiol ligase activity 4/2068 31/18639 0.129032258064516 1.16297497972172 0.455867547095079 0.865456368893419 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2068 31/18639 0.129032258064516 1.16297497972172 0.455867547095079 0.865456368893419 GO:0140457 protein demethylase activity 4/2068 31/18639 0.129032258064516 1.16297497972172 0.455867547095079 0.865456368893419 GO:0004386 helicase activity 18/2068 155/18639 0.116129032258065 1.04667748174955 0.456040140511179 0.865456368893419 GO:0051213 dioxygenase activity 11/2068 93/18639 0.118279569892473 1.06606039807824 0.45905328960461 0.869785180303471 GO:0032451 demethylase activity 5/2068 40/18639 0.125 1.12663201160542 0.461020980081812 0.872122490982791 GO:0016763 pentosyltransferase activity 6/2068 49/18639 0.122448979591837 1.10363952157265 0.464621815994992 0.877536911608983 GO:0004065 arylsulfatase activity 2/2068 14/18639 0.142857142857143 1.28757944183476 0.47058073839648 0.881477772620655 GO:0005313 L-glutamate transmembrane transporter activity 2/2068 14/18639 0.142857142857143 1.28757944183476 0.47058073839648 0.881477772620655 GO:0015386 potassium:proton antiporter activity 2/2068 14/18639 0.142857142857143 1.28757944183476 0.47058073839648 0.881477772620655 GO:0032454 histone H3K9 demethylase activity 2/2068 14/18639 0.142857142857143 1.28757944183476 0.47058073839648 0.881477772620655 GO:0098821 BMP receptor activity 2/2068 14/18639 0.142857142857143 1.28757944183476 0.47058073839648 0.881477772620655 GO:0008094 ATP-dependent activity, acting on DNA 24/2068 210/18639 0.114285714285714 1.03006355346781 0.47116025725094 0.881477772620655 GO:0005200 structural constituent of cytoskeleton 13/2068 112/18639 0.116071428571429 1.04615829649074 0.475600431425764 0.883963977525962 GO:0051082 unfolded protein binding 14/2068 121/18639 0.115702479338843 1.04283293636204 0.476375440826075 0.883963977525962 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/2068 23/18639 0.130434782608696 1.17561601211 0.477697705026656 0.883963977525962 GO:0031681 G-protein beta-subunit binding 3/2068 23/18639 0.130434782608696 1.17561601211 0.477697705026656 0.883963977525962 GO:0099186 structural constituent of postsynapse 3/2068 23/18639 0.130434782608696 1.17561601211 0.477697705026656 0.883963977525962 GO:0140102 catalytic activity, acting on a rRNA 3/2068 23/18639 0.130434782608696 1.17561601211 0.477697705026656 0.883963977525962 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/2068 23/18639 0.130434782608696 1.17561601211 0.477697705026656 0.883963977525962 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/2068 32/18639 0.125 1.12663201160542 0.481193338206219 0.88904772284446 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/2068 41/18639 0.121951219512195 1.09915318205406 0.483324521943034 0.8902163287881 GO:0042169 SH2 domain binding 5/2068 41/18639 0.121951219512195 1.09915318205406 0.483324521943034 0.8902163287881 GO:0016209 antioxidant activity 10/2068 86/18639 0.116279069767442 1.0480297782376 0.487836511651789 0.897135875916911 GO:0016407 acetyltransferase activity 11/2068 96/18639 0.114583333333333 1.0327460106383 0.502755133851557 0.911563355201425 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2068 60/18639 0.116666666666667 1.05152321083172 0.50418713584654 0.911563355201425 GO:0019894 kinesin binding 5/2068 42/18639 0.119047619047619 1.07298286819563 0.505297753083388 0.911563355201425 GO:0005315 phosphate transmembrane transporter activity 3/2068 24/18639 0.125 1.12663201160542 0.506956061732087 0.911563355201425 GO:0050431 transforming growth factor beta binding 3/2068 24/18639 0.125 1.12663201160542 0.506956061732087 0.911563355201425 GO:0050699 WW domain binding 3/2068 24/18639 0.125 1.12663201160542 0.506956061732087 0.911563355201425 GO:0140612 DNA damage sensor activity 3/2068 24/18639 0.125 1.12663201160542 0.506956061732087 0.911563355201425 GO:0004089 carbonate dehydratase activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0005523 tropomyosin binding 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0010181 FMN binding 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0016846 carbon-sulfur lyase activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0017081 chloride channel regulator activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0120283 protein serine/threonine kinase binding 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0141050 histone H3K deacetylase activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0141051 histone H4K deacetylase activity 2/2068 15/18639 0.133333333333333 1.20174081237911 0.507958704666114 0.911563355201425 GO:0033293 monocarboxylic acid binding 9/2068 79/18639 0.113924050632911 1.02680385867835 0.519303344617027 0.930516400309243 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/2068 61/18639 0.114754098360656 1.03428512540825 0.522307064322925 0.93448914520427 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/2068 34/18639 0.117647058823529 1.06035954033451 0.530337697509892 0.946007784747376 GO:0051427 hormone receptor binding 4/2068 34/18639 0.117647058823529 1.06035954033451 0.530337697509892 0.946007784747376 GO:0008139 nuclear localization sequence binding 3/2068 25/18639 0.12 1.0815667311412 0.53533351706722 0.952060206999787 GO:0008483 transaminase activity 3/2068 25/18639 0.12 1.0815667311412 0.53533351706722 0.952060206999787 GO:0061134 peptidase regulator activity 25/2068 226/18639 0.110619469026549 0.997019479296828 0.538093949811416 0.955539031952111 GO:0016887 ATP hydrolysis activity 46/2068 417/18639 0.11031175059952 0.994245995853221 0.54040348216502 0.958091922025913 GO:0005024 transforming growth factor beta receptor activity 2/2068 16/18639 0.125 1.12663201160542 0.543563935560156 0.958091922025913 GO:0015385 sodium:proton antiporter activity 2/2068 16/18639 0.125 1.12663201160542 0.543563935560156 0.958091922025913 GO:0019841 retinol binding 2/2068 16/18639 0.125 1.12663201160542 0.543563935560156 0.958091922025913 GO:0022858 alanine transmembrane transporter activity 2/2068 16/18639 0.125 1.12663201160542 0.543563935560156 0.958091922025913 GO:0030547 signaling receptor inhibitor activity 5/2068 44/18639 0.113636363636364 1.02421091964129 0.548055444573929 0.964306611474717 GO:0008194 UDP-glycosyltransferase activity 16/2068 145/18639 0.110344827586207 0.994544120589609 0.548713189694367 0.964306611474717 GO:0016829 lyase activity 22/2068 200/18639 0.11 0.991436170212766 0.550848479982655 0.966629238137953 GO:0016229 steroid dehydrogenase activity 4/2068 35/18639 0.114285714285714 1.03006355346781 0.554031235107374 0.970780394258939 GO:0140713 histone chaperone activity 18/2068 164/18639 0.109756097560976 0.989237863848658 0.556625073936689 0.973151302953115 GO:0005112 Notch binding 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0005160 transforming growth factor beta receptor binding 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0008198 ferrous iron binding 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0015145 monosaccharide transmembrane transporter activity 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0015216 purine nucleotide transmembrane transporter activity 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0070006 metalloaminopeptidase activity 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0070412 R-SMAD binding 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0097602 cullin family protein binding 3/2068 26/18639 0.115384615384615 1.03996801071269 0.562756687818847 0.973151302953115 GO:0140303 intramembrane lipid transporter activity 5/2068 45/18639 0.111111111111111 1.00145067698259 0.568754595731103 0.981212438020656 GO:0004521 RNA endonuclease activity 8/2068 73/18639 0.10958904109589 0.987732174558173 0.570087983080197 0.981212438020656 GO:0043539 protein serine/threonine kinase activator activity 8/2068 73/18639 0.10958904109589 0.987732174558173 0.570087983080197 0.981212438020656 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0004549 tRNA-specific ribonuclease activity 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0005092 GDP-dissociation inhibitor activity 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0008484 sulfuric ester hydrolase activity 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0030169 low-density lipoprotein particle binding 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0038191 neuropilin binding 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0045236 CXCR chemokine receptor binding 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0048038 quinone binding 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0070402 NADPH binding 2/2068 17/18639 0.117647058823529 1.06035954033451 0.577329540552558 0.981212438020656 GO:0030295 protein kinase activator activity 15/2068 139/18639 0.107913669064748 0.972631952465107 0.585802844742531 0.994191113648753 GO:0004364 glutathione transferase activity 3/2068 27/18639 0.111111111111111 1.00145067698259 0.58916915126184 0.995637200140918 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/2068 27/18639 0.111111111111111 1.00145067698259 0.58916915126184 0.995637200140918 GO:0005385 zinc ion transmembrane transporter activity 3/2068 27/18639 0.111111111111111 1.00145067698259 0.58916915126184 0.995637200140918 GO:0140658 ATP-dependent chromatin remodeler activity 17/2068 158/18639 0.107594936708861 0.96975919986289 0.591426030907815 0.997576194071306 GO:0160215 deacylase activity 7/2068 65/18639 0.107692307692308 0.970636809998512 0.591995973754437 0.997576194071306 GO:0023023 MHC protein complex binding 4/2068 37/18639 0.108108108108108 0.974384442469549 0.599416550023696 0.999999999999858 GO:0043394 proteoglycan binding 4/2068 37/18639 0.108108108108108 0.974384442469549 0.599416550023696 0.999999999999858 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0008409 5'-3' exonuclease activity 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0015172 acidic amino acid transmembrane transporter activity 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0070628 proteasome binding 2/2068 18/18639 0.111111111111111 1.00145067698259 0.609225272268812 0.999999999999858 GO:0003689 DNA clamp loader activity 17/2068 160/18639 0.10625 0.957637209864603 0.612887454431691 0.999999999999858 GO:0051119 sugar transmembrane transporter activity 3/2068 28/18639 0.107142857142857 0.965684581376071 0.614529714081445 0.999999999999858 GO:0000510 H3-H4 histone complex chaperone activity 16/2068 151/18639 0.105960264900662 0.955025811162207 0.616278267560875 0.999999999999858 GO:0140584 chromatin extrusion motor activity 16/2068 151/18639 0.105960264900662 0.955025811162207 0.616278267560875 0.999999999999858 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 16/2068 151/18639 0.105960264900662 0.955025811162207 0.616278267560875 0.999999999999858 GO:0140849 ATP-dependent H2AZ histone chaperone activity 16/2068 151/18639 0.105960264900662 0.955025811162207 0.616278267560875 0.999999999999858 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2068 57/18639 0.105263157894737 0.948742746615087 0.617040078002993 0.999999999999858 GO:0005501 retinoid binding 4/2068 38/18639 0.105263157894737 0.948742746615087 0.621035675667959 0.999999999999858 GO:0019840 isoprenoid binding 4/2068 38/18639 0.105263157894737 0.948742746615087 0.621035675667959 0.999999999999858 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 9/2068 86/18639 0.104651162790698 0.943226800413837 0.624925740003596 0.999999999999858 GO:0015616 DNA translocase activity 16/2068 152/18639 0.105263157894737 0.948742746615087 0.627082894842033 0.999999999999858 GO:0140674 ATP-dependent histone chaperone activity 16/2068 152/18639 0.105263157894737 0.948742746615087 0.627082894842033 0.999999999999858 GO:0004518 nuclease activity 22/2068 209/18639 0.105263157894737 0.948742746615087 0.636582189882969 0.999999999999858 GO:0061775 cohesin loader activity 16/2068 153/18639 0.104575163398693 0.942541813630675 0.637739922133101 0.999999999999858 GO:0004629 phospholipase C activity 3/2068 29/18639 0.103448275862069 0.932385113052758 0.638810731568144 0.999999999999858 GO:0106222 lncRNA binding 3/2068 29/18639 0.103448275862069 0.932385113052758 0.638810731568144 0.999999999999858 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0022821 solute:potassium antiporter activity 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0042834 peptidoglycan binding 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0070003 threonine-type peptidase activity 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0097001 ceramide binding 2/2068 19/18639 0.105263157894737 0.948742746615087 0.63925022541825 0.999999999999858 GO:0000217 DNA secondary structure binding 4/2068 39/18639 0.102564102564103 0.924416009522392 0.641903352935094 0.999999999999858 GO:0004879 nuclear receptor activity 6/2068 59/18639 0.101694915254237 0.916581975543389 0.651124641203706 0.999999999999858 GO:0036002 pre-mRNA binding 6/2068 59/18639 0.101694915254237 0.916581975543389 0.651124641203706 0.999999999999858 GO:0015215 nucleotide transmembrane transporter activity 3/2068 30/18639 0.1 0.901305609284333 0.66199650105728 0.999999999999858 GO:0016769 transferase activity, transferring nitrogenous groups 3/2068 30/18639 0.1 0.901305609284333 0.66199650105728 0.999999999999858 GO:0048019 receptor antagonist activity 3/2068 30/18639 0.1 0.901305609284333 0.66199650105728 0.999999999999858 GO:0061791 GTPase motor activity 4/2068 40/18639 0.1 0.901305609284333 0.662001394363236 0.999999999999858 GO:1990606 membrane scission GTPase motor activity 4/2068 40/18639 0.1 0.901305609284333 0.662001394363236 0.999999999999858 GO:0015605 organophosphate ester transmembrane transporter activity 5/2068 50/18639 0.1 0.901305609284333 0.664208932636926 0.999999999999858 GO:0001614 purinergic nucleotide receptor activity 2/2068 20/18639 0.1 0.901305609284333 0.667426703560869 0.999999999999858 GO:0015095 magnesium ion transmembrane transporter activity 2/2068 20/18639 0.1 0.901305609284333 0.667426703560869 0.999999999999858 GO:0016502 nucleotide receptor activity 2/2068 20/18639 0.1 0.901305609284333 0.667426703560869 0.999999999999858 GO:0031418 L-ascorbic acid binding 2/2068 20/18639 0.1 0.901305609284333 0.667426703560869 0.999999999999858 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/2068 60/18639 0.1 0.901305609284333 0.667451030687835 0.999999999999858 GO:0098531 ligand-modulated transcription factor activity 6/2068 60/18639 0.1 0.901305609284333 0.667451030687835 0.999999999999858 GO:0008236 serine-type peptidase activity 20/2068 194/18639 0.103092783505155 0.929181040499312 0.670669062458938 0.999999999999858 GO:0004252 serine-type endopeptidase activity 18/2068 176/18639 0.102272727272727 0.921789827677158 0.678994146191885 0.999999999999858 GO:0140828 metal cation:monoatomic cation antiporter activity 4/2068 41/18639 0.0975609756097561 0.879322545643251 0.681317813003258 0.999999999999858 GO:0008327 methyl-CpG binding 3/2068 31/18639 0.0967741935483871 0.87223123479129 0.684081746124658 0.999999999999858 GO:0047499 calcium-independent phospholipase A2 activity 3/2068 31/18639 0.0967741935483871 0.87223123479129 0.684081746124658 0.999999999999858 GO:0072349 modified amino acid transmembrane transporter activity 3/2068 31/18639 0.0967741935483871 0.87223123479129 0.684081746124658 0.999999999999858 GO:0140299 molecular sensor activity 7/2068 71/18639 0.0985915492957746 0.888611164083145 0.685849044601348 0.999999999999858 GO:0001618 virus receptor activity 8/2068 81/18639 0.0987654320987654 0.890178379540082 0.688887845448662 0.999999999999858 GO:0000182 rDNA binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0001094 TFIID-class transcription factor complex binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0004090 carbonyl reductase (NADPH) activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0008239 dipeptidyl-peptidase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0008519 ammonium channel activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0015187 glycine transmembrane transporter activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0015279 store-operated calcium channel activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0015643 toxic substance binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0016427 tRNA (cytidine) methyltransferase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0016783 sulfurtransferase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0016868 intramolecular phosphotransferase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0031434 mitogen-activated protein kinase kinase binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0031720 haptoglobin binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0035256 G protein-coupled glutamate receptor binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0042975 peroxisome proliferator activated receptor binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0043121 neurotrophin binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0043208 glycosphingolipid binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0043422 protein kinase B binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0098505 G-rich strand telomeric DNA binding 1/2068 10/18639 0.1 0.901305609284333 0.691588763980243 0.999999999999858 GO:0001846 opsonin binding 2/2068 21/18639 0.0952380952380952 0.858386294556507 0.693795084625756 0.999999999999858 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2068 21/18639 0.0952380952380952 0.858386294556507 0.693795084625756 0.999999999999858 GO:0008373 sialyltransferase activity 2/2068 21/18639 0.0952380952380952 0.858386294556507 0.693795084625756 0.999999999999858 GO:0010314 phosphatidylinositol-5-phosphate binding 2/2068 21/18639 0.0952380952380952 0.858386294556507 0.693795084625756 0.999999999999858 GO:0061891 calcium ion sensor activity 2/2068 21/18639 0.0952380952380952 0.858386294556507 0.693795084625756 0.999999999999858 GO:0016758 hexosyltransferase activity 20/2068 197/18639 0.101522842639594 0.915031075415566 0.697243806140686 0.999999999999858 GO:0005080 protein kinase C binding 5/2068 52/18639 0.0961538461538462 0.866640008927243 0.698273922813785 0.999999999999858 GO:0015179 L-amino acid transmembrane transporter activity 6/2068 62/18639 0.0967741935483871 0.87223123479129 0.698618205169094 0.999999999999858 GO:1902936 phosphatidylinositol bisphosphate binding 11/2068 111/18639 0.0990990990990991 0.89318573893042 0.699235366136064 0.999999999999858 GO:0008307 structural constituent of muscle 4/2068 42/18639 0.0952380952380952 0.858386294556507 0.699846240363245 0.999999999999858 GO:0042379 chemokine receptor binding 7/2068 72/18639 0.0972222222222222 0.876269342359768 0.700063381243104 0.999999999999858 GO:0140272 exogenous protein binding 8/2068 82/18639 0.0975609756097561 0.879322545643251 0.702177089628322 0.999999999999858 GO:0004175 endopeptidase activity 42/2068 405/18639 0.103703703703704 0.934687298517086 0.703806220766092 0.999999999999858 GO:0042910 xenobiotic transmembrane transporter activity 3/2068 32/18639 0.09375 0.844974008704062 0.705070202116221 0.999999999999858 GO:0043425 bHLH transcription factor binding 3/2068 32/18639 0.09375 0.844974008704062 0.705070202116221 0.999999999999858 GO:0047498 calcium-dependent phospholipase A2 activity 3/2068 32/18639 0.09375 0.844974008704062 0.705070202116221 0.999999999999858 GO:0017171 serine hydrolase activity 20/2068 198/18639 0.101010101010101 0.910409706347811 0.705823656187033 0.999999999999858 GO:0016860 intramolecular oxidoreductase activity 5/2068 53/18639 0.0943396226415094 0.850288310645597 0.714382849937312 0.999999999999858 GO:0001540 amyloid-beta binding 8/2068 83/18639 0.0963855421686747 0.868728298105381 0.715093745137302 0.999999999999858 GO:0033218 amide binding 25/2068 247/18639 0.101214574898785 0.912252640976045 0.717478305599359 0.999999999999858 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/2068 43/18639 0.0930232558139535 0.838423822590077 0.717585358143189 0.999999999999858 GO:0031683 G-protein beta/gamma-subunit complex binding 2/2068 22/18639 0.0909090909090909 0.81936873571303 0.718409539215686 0.999999999999858 GO:0140784 metal ion sensor activity 2/2068 22/18639 0.0909090909090909 0.81936873571303 0.718409539215686 0.999999999999858 GO:0016757 glycosyltransferase activity 27/2068 267/18639 0.101123595505618 0.911432638602134 0.724871560350526 0.999999999999858 GO:0030296 protein tyrosine kinase activator activity 3/2068 33/18639 0.0909090909090909 0.81936873571303 0.724973308919033 0.999999999999858 GO:0001851 complement component C3b binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0008046 axon guidance receptor activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0008432 JUN kinase binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0008503 benzodiazepine receptor activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0010854 adenylate cyclase regulator activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0043522 leucine zipper domain binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0048407 platelet-derived growth factor binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0050998 nitric-oxide synthase binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0140031 phosphorylation-dependent protein binding 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0140537 transcription regulator activator activity 1/2068 11/18639 0.0909090909090909 0.81936873571303 0.725825407712534 0.999999999999858 GO:0019955 cytokine binding 14/2068 144/18639 0.0972222222222222 0.876269342359768 0.738927876159538 0.999999999999858 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0003887 DNA-directed DNA polymerase activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0005212 structural constituent of eye lens 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0008171 O-methyltransferase activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0016493 C-C chemokine receptor activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0042171 lysophosphatidic acid acyltransferase activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0071617 lysophospholipid acyltransferase activity 2/2068 23/18639 0.0869565217391304 0.783744008073333 0.741334475805117 0.999999999999858 GO:0046915 transition metal ion transmembrane transporter activity 4/2068 45/18639 0.0888888888888889 0.801160541586074 0.750712374258067 0.999999999999858 GO:0008235 metalloexopeptidase activity 6/2068 66/18639 0.0909090909090909 0.81936873571303 0.75486644266752 0.999999999999858 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0004000 adenosine deaminase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0005078 MAP-kinase scaffold activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0005436 sodium:phosphate symporter activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0008179 adenylate cyclase binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0008504 monoamine transmembrane transporter activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0010853 cyclase activator activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0015368 calcium:monoatomic cation antiporter activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0016423 tRNA (guanine) methyltransferase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0016840 carbon-nitrogen lyase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0017166 vinculin binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0031543 peptidyl-proline dioxygenase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0035251 UDP-glucosyltransferase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0035259 nuclear glucocorticoid receptor binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0042301 phosphate ion binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0043047 single-stranded telomeric DNA binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0070008 serine-type exopeptidase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0097677 STAT family protein binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:1990459 transferrin receptor binding 1/2068 12/18639 0.0833333333333333 0.751088007736944 0.756263085232959 0.999999999999858 GO:0003779 actin binding 45/2068 443/18639 0.101580135440181 0.91554745864097 0.758881202634241 0.999999999999858 GO:0004623 phospholipase A2 activity 3/2068 35/18639 0.0857142857142857 0.772547665100857 0.761600679949723 0.999999999999858 GO:0004622 lysophospholipase activity 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0005540 hyaluronic acid binding 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0015149 hexose transmembrane transporter activity 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0019957 C-C chemokine binding 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0055056 D-glucose transmembrane transporter activity 2/2068 24/18639 0.0833333333333333 0.751088007736944 0.762641604357211 0.999999999999858 GO:0003724 RNA helicase activity 7/2068 77/18639 0.0909090909090909 0.81936873571303 0.764647641211993 0.999999999999858 GO:0042626 ATPase-coupled transmembrane transporter activity 9/2068 98/18639 0.0918367346938776 0.827729641179489 0.772744525288319 0.999999999999858 GO:0004190 aspartic-type endopeptidase activity 3/2068 36/18639 0.0833333333333333 0.751088007736944 0.778376109711883 0.999999999999858 GO:0016409 palmitoyltransferase activity 3/2068 36/18639 0.0833333333333333 0.751088007736944 0.778376109711883 0.999999999999858 GO:0030145 manganese ion binding 6/2068 68/18639 0.0882352941176471 0.795269655250882 0.779942415660983 0.999999999999858 GO:0140359 ABC-type transporter activity 4/2068 47/18639 0.0851063829787234 0.767068603646241 0.780769090625878 0.999999999999858 GO:0070851 growth factor receptor binding 13/2068 139/18639 0.0935251798561151 0.842947692136426 0.782087538170905 0.999999999999858 GO:0001848 complement binding 2/2068 25/18639 0.08 0.721044487427466 0.782407524991123 0.999999999999858 GO:0005537 D-mannose binding 2/2068 25/18639 0.08 0.721044487427466 0.782407524991123 0.999999999999858 GO:0042974 nuclear retinoic acid receptor binding 2/2068 25/18639 0.08 0.721044487427466 0.782407524991123 0.999999999999858 GO:0004465 lipoprotein lipase activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0008417 fucosyltransferase activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0017154 semaphorin receptor activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0030955 potassium ion binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0035325 Toll-like receptor binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0035673 oligopeptide transmembrane transporter activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0045159 myosin II binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0051011 microtubule minus-end binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0061459 L-arginine transmembrane transporter activity 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0070700 BMP receptor binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0071837 HMG box domain binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0089720 caspase binding 1/2068 13/18639 0.0769230769230769 0.693312007141794 0.78332315608378 0.999999999999858 GO:0008186 ATP-dependent activity, acting on RNA 7/2068 79/18639 0.0886075949367089 0.798625223416497 0.787447504736529 0.999999999999858 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/2068 229/18639 0.0960698689956332 0.865883118089752 0.793613064578273 0.999999999999858 GO:0030280 structural constituent of skin epidermis 3/2068 37/18639 0.0810810810810811 0.730788331852162 0.794166659096135 0.999999999999858 GO:0070001 aspartic-type peptidase activity 3/2068 37/18639 0.0810810810810811 0.730788331852162 0.794166659096135 0.999999999999858 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/2068 48/18639 0.0833333333333333 0.751088007736944 0.794681655910643 0.999999999999858 GO:0038187 pattern recognition receptor activity 4/2068 48/18639 0.0833333333333333 0.751088007736944 0.794681655910643 0.999999999999858 GO:0005262 calcium channel activity 12/2068 131/18639 0.0916030534351145 0.825623458886412 0.798836675910734 0.999999999999858 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2068 26/18639 0.0769230769230769 0.693312007141794 0.800711761422146 0.999999999999858 GO:0004435 phosphatidylinositol phospholipase C activity 2/2068 26/18639 0.0769230769230769 0.693312007141794 0.800711761422146 0.999999999999858 GO:0004950 chemokine receptor activity 2/2068 26/18639 0.0769230769230769 0.693312007141794 0.800711761422146 0.999999999999858 GO:0019865 immunoglobulin binding 2/2068 26/18639 0.0769230769230769 0.693312007141794 0.800711761422146 0.999999999999858 GO:0072341 modified amino acid binding 8/2068 91/18639 0.0879120879120879 0.792356579590622 0.804816638907557 0.999999999999858 GO:0005161 platelet-derived growth factor receptor binding 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0005344 oxygen carrier activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0005347 ATP transmembrane transporter activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0008191 metalloendopeptidase inhibitor activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0008331 high voltage-gated calcium channel activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0008494 translation activator activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0008559 ABC-type xenobiotic transporter activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0019763 immunoglobulin receptor activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0030983 mismatched DNA binding 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0031404 chloride ion binding 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0061783 peptidoglycan muralytic activity 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0098847 sequence-specific single stranded DNA binding 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:1901612 cardiolipin binding 1/2068 14/18639 0.0714285714285714 0.643789720917381 0.807380265136649 0.999999999999858 GO:0035254 glutamate receptor binding 4/2068 49/18639 0.0816326530612245 0.735759681048435 0.807874159320469 0.999999999999858 GO:0042887 amide transmembrane transporter activity 3/2068 38/18639 0.0789473684210526 0.711557059961315 0.809006457675693 0.999999999999858 GO:0052689 carboxylic ester hydrolase activity 8/2068 92/18639 0.0869565217391304 0.783744008073333 0.814350563703314 0.999999999999858 GO:0016405 CoA-ligase activity 2/2068 27/18639 0.0740740740740741 0.667633784655061 0.81763517023497 0.999999999999858 GO:0023026 MHC class II protein complex binding 2/2068 27/18639 0.0740740740740741 0.667633784655061 0.81763517023497 0.999999999999858 GO:0048020 CCR chemokine receptor binding 4/2068 50/18639 0.08 0.721044487427466 0.820366787727734 0.999999999999858 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/2068 39/18639 0.0769230769230769 0.693312007141794 0.822931716404076 0.999999999999858 GO:0000774 adenyl-nucleotide exchange factor activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0004953 icosanoid receptor activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0015929 hexosaminidase activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0030553 cGMP binding 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0034483 heparan sulfate sulfotransferase activity 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0045504 dynein heavy chain binding 1/2068 15/18639 0.0666666666666667 0.600870406189555 0.828767519455973 0.999999999999858 GO:0015297 antiporter activity 12/2068 135/18639 0.0888888888888889 0.801160541586074 0.830208977678048 0.999999999999858 GO:0016597 amino acid binding 4/2068 51/18639 0.0784313725490196 0.706906360223006 0.832181180615661 0.999999999999858 GO:0016830 carbon-carbon lyase activity 4/2068 51/18639 0.0784313725490196 0.706906360223006 0.832181180615661 0.999999999999858 GO:0050698 proteoglycan sulfotransferase activity 2/2068 28/18639 0.0714285714285714 0.643789720917381 0.833258666862165 0.999999999999858 GO:0051019 mitogen-activated protein kinase binding 2/2068 28/18639 0.0714285714285714 0.643789720917381 0.833258666862165 0.999999999999858 GO:0051959 dynein light intermediate chain binding 2/2068 28/18639 0.0714285714285714 0.643789720917381 0.833258666862165 0.999999999999858 GO:0004177 aminopeptidase activity 3/2068 40/18639 0.075 0.67597920696325 0.835980120893874 0.999999999999858 GO:0015144 carbohydrate transmembrane transporter activity 3/2068 40/18639 0.075 0.67597920696325 0.835980120893874 0.999999999999858 GO:0015085 calcium ion transmembrane transporter activity 13/2068 147/18639 0.0884353741496599 0.797072987802471 0.842894255673292 0.999999999999858 GO:0004181 metallocarboxypeptidase activity 2/2068 29/18639 0.0689655172413793 0.621590075368505 0.847662217624685 0.999999999999858 GO:0035250 UDP-galactosyltransferase activity 2/2068 29/18639 0.0689655172413793 0.621590075368505 0.847662217624685 0.999999999999858 GO:0051861 glycolipid binding 2/2068 29/18639 0.0689655172413793 0.621590075368505 0.847662217624685 0.999999999999858 GO:0003688 DNA replication origin binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0005149 interleukin-1 receptor binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0005159 insulin-like growth factor receptor binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0005521 lamin binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0008296 3'-5'-DNA exonuclease activity 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0015378 sodium:chloride symporter activity 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0070411 I-SMAD binding 1/2068 16/18639 0.0625 0.563316005802708 0.847781091715694 0.999999999999858 GO:0001530 lipopolysaccharide binding 3/2068 41/18639 0.0731707317073171 0.659491909232439 0.848190303095765 0.999999999999858 GO:0004896 cytokine receptor activity 8/2068 96/18639 0.0833333333333333 0.751088007736944 0.848937173021545 0.999999999999858 GO:0042277 peptide binding 23/2068 249/18639 0.0923694779116466 0.832531285684323 0.851941065419746 0.999999999999858 GO:0044183 protein folding chaperone 6/2068 75/18639 0.08 0.721044487427466 0.852492078738169 0.999999999999858 GO:0042056 chemoattractant activity 3/2068 42/18639 0.0714285714285714 0.643789720917381 0.85960138484442 0.999999999999858 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/2068 30/18639 0.0666666666666667 0.600870406189555 0.860924054522356 0.999999999999858 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/2068 54/18639 0.0740740740740741 0.667633784655061 0.86378680000171 0.999999999999858 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0009881 photoreceptor activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0015278 intracellularly gated calcium channel activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0017110 nucleoside diphosphate phosphatase activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0019198 transmembrane receptor protein phosphatase activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0046965 nuclear retinoid X receptor binding 1/2068 17/18639 0.0588235294117647 0.530179770167255 0.86468431366339 0.999999999999858 GO:0005539 glycosaminoglycan binding 22/2068 242/18639 0.0909090909090909 0.81936873571303 0.866381047913374 0.999999999999858 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/2068 130/18639 0.0846153846153846 0.762643207855974 0.86653604501065 0.999999999999858 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2068 31/18639 0.0645161290322581 0.58148748986086 0.873120075791163 0.999999999999858 GO:0016411 acylglycerol O-acyltransferase activity 2/2068 31/18639 0.0645161290322581 0.58148748986086 0.873120075791163 0.999999999999858 GO:0098632 cell-cell adhesion mediator activity 4/2068 55/18639 0.0727272727272727 0.655494988570424 0.873123419020395 0.999999999999858 GO:0046906 tetrapyrrole binding 13/2068 152/18639 0.0855263157894737 0.770853481624758 0.873724363386199 0.999999999999858 GO:0061135 endopeptidase regulator activity 16/2068 184/18639 0.0869565217391304 0.783744008073333 0.87951437988095 0.999999999999858 GO:0005126 cytokine receptor binding 25/2068 275/18639 0.0909090909090909 0.81936873571303 0.879652748432695 0.999999999999858 GO:0003746 translation elongation factor activity 1/2068 18/18639 0.0555555555555556 0.500725338491296 0.879711316098366 0.999999999999858 GO:0008308 voltage-gated monoatomic anion channel activity 1/2068 18/18639 0.0555555555555556 0.500725338491296 0.879711316098366 0.999999999999858 GO:0015373 monoatomic anion:sodium symporter activity 1/2068 18/18639 0.0555555555555556 0.500725338491296 0.879711316098366 0.999999999999858 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2068 18/18639 0.0555555555555556 0.500725338491296 0.879711316098366 0.999999999999858 GO:0034185 apolipoprotein binding 1/2068 18/18639 0.0555555555555556 0.500725338491296 0.879711316098366 0.999999999999858 GO:0016790 thiolester hydrolase activity 3/2068 44/18639 0.0681818181818182 0.614526551784772 0.880182896896786 0.999999999999858 GO:0030170 pyridoxal phosphate binding 4/2068 56/18639 0.0714285714285714 0.643789720917381 0.881901909243972 0.999999999999858 GO:0170055 lipid transmembrane transporter activity 4/2068 56/18639 0.0714285714285714 0.643789720917381 0.881901909243972 0.999999999999858 GO:0008378 galactosyltransferase activity 2/2068 32/18639 0.0625 0.563316005802708 0.884323400702826 0.999999999999858 GO:0071813 lipoprotein particle binding 2/2068 32/18639 0.0625 0.563316005802708 0.884323400702826 0.999999999999858 GO:0071814 protein-lipid complex binding 2/2068 32/18639 0.0625 0.563316005802708 0.884323400702826 0.999999999999858 GO:0008009 chemokine activity 3/2068 45/18639 0.0666666666666667 0.600870406189555 0.88943079137098 0.999999999999858 GO:0070279 vitamin B6 binding 4/2068 57/18639 0.0701754385964912 0.632495164410058 0.89014708492207 0.999999999999858 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0008301 DNA binding, bending 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0015245 fatty acid transmembrane transporter activity 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0031420 alkali metal ion binding 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0046527 glucosyltransferase activity 1/2068 19/18639 0.0526315789473684 0.474371373307544 0.893070265580594 0.999999999999858 GO:0042923 neuropeptide binding 2/2068 33/18639 0.0606060606060606 0.546245823808687 0.894604051785651 0.999999999999858 GO:0140416 transcription regulator inhibitor activity 2/2068 33/18639 0.0606060606060606 0.546245823808687 0.894604051785651 0.999999999999858 GO:0004180 carboxypeptidase activity 3/2068 46/18639 0.0652173913043478 0.587808006054999 0.89803400439716 0.999999999999858 GO:0051015 actin filament binding 18/2068 209/18639 0.0861244019138756 0.776244065412344 0.899738673113665 0.999999999999858 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/2068 70/18639 0.0714285714285714 0.643789720917381 0.900391330635479 0.999999999999858 GO:0016782 transferase activity, transferring sulphur-containing groups 5/2068 70/18639 0.0714285714285714 0.643789720917381 0.900391330635479 0.999999999999858 GO:0008175 tRNA methyltransferase activity 2/2068 34/18639 0.0588235294117647 0.530179770167255 0.904028741694195 0.999999999999858 GO:0015020 glucuronosyltransferase activity 2/2068 34/18639 0.0588235294117647 0.530179770167255 0.904028741694195 0.999999999999858 GO:0090482 vitamin transmembrane transporter activity 2/2068 34/18639 0.0588235294117647 0.530179770167255 0.904028741694195 0.999999999999858 GO:0010851 cyclase regulator activity 1/2068 20/18639 0.05 0.450652804642166 0.904946242529001 0.999999999999858 GO:0030627 pre-mRNA 5'-splice site binding 1/2068 20/18639 0.05 0.450652804642166 0.904946242529001 0.999999999999858 GO:0140664 ATP-dependent DNA damage sensor activity 1/2068 20/18639 0.05 0.450652804642166 0.904946242529001 0.999999999999858 GO:0015459 potassium channel regulator activity 4/2068 59/18639 0.0677966101694915 0.611054650362259 0.905135872042097 0.999999999999858 GO:0030414 peptidase inhibitor activity 14/2068 169/18639 0.0828402366863905 0.746643699998855 0.906229322539482 0.999999999999858 GO:0016853 isomerase activity 15/2068 180/18639 0.0833333333333333 0.751088007736944 0.908396605901448 0.999999999999858 GO:0004519 endonuclease activity 10/2068 127/18639 0.078740157480315 0.709689456129396 0.908862261114422 0.999999999999858 GO:0005343 organic acid:sodium symporter activity 2/2068 35/18639 0.0571428571428571 0.515031776733904 0.912660745436284 0.999999999999858 GO:0034061 DNA polymerase activity 2/2068 35/18639 0.0571428571428571 0.515031776733904 0.912660745436284 0.999999999999858 GO:0005123 death receptor binding 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:0015125 bile acid transmembrane transporter activity 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:0015174 basic amino acid transmembrane transporter activity 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:0036122 BMP binding 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:0051428 peptide hormone receptor binding 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:0070182 DNA polymerase binding 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:1904047 S-adenosyl-L-methionine binding 1/2068 21/18639 0.0476190476190476 0.429193147278254 0.915503800424163 0.999999999999858 GO:1901681 sulfur compound binding 24/2068 275/18639 0.0872727272727273 0.786593986284509 0.916254134763267 0.999999999999858 GO:0004866 endopeptidase inhibitor activity 13/2068 161/18639 0.0807453416149068 0.727762293210952 0.916917428227705 0.999999999999858 GO:0140097 catalytic activity, acting on DNA 30/2068 336/18639 0.0892857142857143 0.804737151146726 0.917040862589375 0.999999999999858 GO:0008201 heparin binding 14/2068 172/18639 0.0813953488372093 0.733620844766317 0.918426825180211 0.999999999999858 GO:0060590 ATPase regulator activity 3/2068 49/18639 0.0612244897959184 0.551819760786326 0.920338063480784 0.999999999999858 GO:0045505 dynein intermediate chain binding 2/2068 36/18639 0.0555555555555556 0.500725338491296 0.920559841655367 0.999999999999858 GO:0048029 monosaccharide binding 5/2068 74/18639 0.0675675675675676 0.608990276543468 0.924402415493745 0.999999999999858 GO:0008093 cytoskeletal anchor activity 1/2068 22/18639 0.0454545454545455 0.409684367856515 0.924889241434091 0.999999999999858 GO:0015377 chloride:monoatomic cation symporter activity 1/2068 22/18639 0.0454545454545455 0.409684367856515 0.924889241434091 0.999999999999858 GO:0016881 acid-amino acid ligase activity 1/2068 22/18639 0.0454545454545455 0.409684367856515 0.924889241434091 0.999999999999858 GO:0033691 sialic acid binding 1/2068 22/18639 0.0454545454545455 0.409684367856515 0.924889241434091 0.999999999999858 GO:0050660 flavin adenine dinucleotide binding 6/2068 86/18639 0.0697674418604651 0.628817866942558 0.926038855239187 0.999999999999858 GO:1901682 sulfur compound transmembrane transporter activity 4/2068 63/18639 0.0634920634920635 0.572257529704338 0.929774156282668 0.999999999999858 GO:0005506 iron ion binding 12/2068 154/18639 0.0779220779220779 0.702316059182597 0.930996164872782 0.999999999999858 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2068 23/18639 0.0434782608695652 0.391872004036666 0.933232639871771 0.999999999999858 GO:0005283 amino acid:sodium symporter activity 1/2068 23/18639 0.0434782608695652 0.391872004036666 0.933232639871771 0.999999999999858 GO:0031406 carboxylic acid binding 15/2068 187/18639 0.0802139037433155 0.722972413864438 0.933632056699748 0.999999999999858 GO:0098631 cell adhesion mediator activity 5/2068 76/18639 0.0657894736842105 0.592964216634429 0.934361730905118 0.999999999999858 GO:0005109 frizzled binding 2/2068 38/18639 0.0526315789473684 0.474371373307544 0.934380967649874 0.999999999999858 GO:0043531 ADP binding 2/2068 38/18639 0.0526315789473684 0.474371373307544 0.934380967649874 0.999999999999858 GO:0043177 organic acid binding 15/2068 189/18639 0.0793650793650794 0.715321912130423 0.939654419645441 0.999999999999858 GO:0004806 triacylglycerol lipase activity 1/2068 24/18639 0.0416666666666667 0.375544003868472 0.940649641415883 0.999999999999858 GO:0015295 solute:proton symporter activity 1/2068 24/18639 0.0416666666666667 0.375544003868472 0.940649641415883 0.999999999999858 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2068 24/18639 0.0416666666666667 0.375544003868472 0.940649641415883 0.999999999999858 GO:0030215 semaphorin receptor binding 1/2068 24/18639 0.0416666666666667 0.375544003868472 0.940649641415883 0.999999999999858 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/2068 24/18639 0.0416666666666667 0.375544003868472 0.940649641415883 0.999999999999858 GO:0017046 peptide hormone binding 3/2068 53/18639 0.0566037735849057 0.510172986387358 0.943148061660535 0.999999999999858 GO:0008238 exopeptidase activity 7/2068 102/18639 0.0686274509803922 0.61854306519513 0.944511550569859 0.999999999999858 GO:0071855 neuropeptide receptor binding 2/2068 40/18639 0.05 0.450652804642166 0.945901311006636 0.999999999999858 GO:0071949 FAD binding 2/2068 40/18639 0.05 0.450652804642166 0.945901311006636 0.999999999999858 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/2068 91/18639 0.0659340659340659 0.594267434692967 0.947114013741466 0.999999999999858 GO:0000030 mannosyltransferase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0005251 delayed rectifier potassium channel activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0015271 outward rectifier potassium channel activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0015645 fatty acid ligase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0015662 P-type ion transporter activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0019707 protein-cysteine S-acyltransferase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0047617 fatty acyl-CoA hydrolase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0120515 fatty acid-CoA ligase activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0140358 P-type transmembrane transporter activity 1/2068 25/18639 0.04 0.360522243713733 0.947243062933581 0.999999999999858 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 14/2068 181/18639 0.0773480662983425 0.697142460219926 0.947317350339498 0.999999999999858 GO:0001217 DNA-binding transcription repressor activity 23/2068 278/18639 0.0827338129496403 0.745684496889915 0.950584825710822 0.999999999999858 GO:0005178 integrin binding 12/2068 161/18639 0.0745341614906832 0.671780578348571 0.952229046640055 0.999999999999858 GO:0004529 DNA exonuclease activity 1/2068 26/18639 0.0384615384615385 0.346656003570897 0.953104314994038 0.999999999999858 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/2068 26/18639 0.0384615384615385 0.346656003570897 0.953104314994038 0.999999999999858 GO:0016289 acyl-CoA hydrolase activity 1/2068 26/18639 0.0384615384615385 0.346656003570897 0.953104314994038 0.999999999999858 GO:0030247 polysaccharide binding 1/2068 26/18639 0.0384615384615385 0.346656003570897 0.953104314994038 0.999999999999858 GO:0030507 spectrin binding 1/2068 26/18639 0.0384615384615385 0.346656003570897 0.953104314994038 0.999999999999858 GO:0015101 organic cation transmembrane transporter activity 5/2068 81/18639 0.0617283950617284 0.556361487212551 0.954307324612829 0.999999999999858 GO:0030246 carbohydrate binding 23/2068 280/18639 0.0821428571428571 0.740358179054988 0.954556213853011 0.999999999999858 GO:0004520 DNA endonuclease activity 2/2068 42/18639 0.0476190476190476 0.429193147278254 0.955477669279178 0.999999999999858 GO:0042562 hormone binding 6/2068 94/18639 0.0638297872340425 0.57530145273468 0.957003416310198 0.999999999999858 GO:0001671 ATPase activator activity 1/2068 27/18639 0.037037037037037 0.333816892327531 0.958314666715541 0.999999999999858 GO:0005104 fibroblast growth factor receptor binding 1/2068 27/18639 0.037037037037037 0.333816892327531 0.958314666715541 0.999999999999858 GO:0008395 steroid hydroxylase activity 1/2068 27/18639 0.037037037037037 0.333816892327531 0.958314666715541 0.999999999999858 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/2068 27/18639 0.037037037037037 0.333816892327531 0.958314666715541 0.999999999999858 GO:0035255 ionotropic glutamate receptor binding 1/2068 27/18639 0.037037037037037 0.333816892327531 0.958314666715541 0.999999999999858 GO:0005245 voltage-gated calcium channel activity 2/2068 43/18639 0.0465116279069767 0.419211911295038 0.95963499037343 0.999999999999858 GO:0004867 serine-type endopeptidase inhibitor activity 6/2068 95/18639 0.0631578947368421 0.569245647969052 0.959907022175344 0.999999999999858 GO:0020037 heme binding 10/2068 142/18639 0.0704225352112676 0.634722260059389 0.960571565790646 0.999999999999858 GO:0016866 intramolecular transferase activity 1/2068 28/18639 0.0357142857142857 0.32189486045869 0.962946370413814 0.999999999999858 GO:0045499 chemorepellent activity 1/2068 28/18639 0.0357142857142857 0.32189486045869 0.962946370413814 0.999999999999858 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/2068 44/18639 0.0454545454545455 0.409684367856515 0.963418423396128 0.999999999999858 GO:0004620 phospholipase activity 7/2068 109/18639 0.0642201834862385 0.578820116054159 0.965022373941552 0.999999999999858 GO:0001664 G protein-coupled receptor binding 24/2068 297/18639 0.0808080808080808 0.728327765078249 0.965507415960282 0.999999999999858 GO:0005416 amino acid:monoatomic cation symporter activity 1/2068 29/18639 0.0344827586206897 0.310795037684253 0.967063661584855 0.999999999999858 GO:0016417 S-acyltransferase activity 1/2068 29/18639 0.0344827586206897 0.310795037684253 0.967063661584855 0.999999999999858 GO:0099604 ligand-gated calcium channel activity 1/2068 29/18639 0.0344827586206897 0.310795037684253 0.967063661584855 0.999999999999858 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/2068 122/18639 0.0655737704918033 0.591020071661858 0.967540067562702 0.999999999999858 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 21/2068 268/18639 0.0783582089552239 0.706246932648171 0.969700240640401 0.999999999999858 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2068 46/18639 0.0434782608695652 0.391872004036666 0.969988149707029 0.999999999999858 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2068 30/18639 0.0333333333333333 0.300435203094778 0.970723648035286 0.999999999999858 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/2068 30/18639 0.0333333333333333 0.300435203094778 0.970723648035286 0.999999999999858 GO:0033612 receptor serine/threonine kinase binding 1/2068 30/18639 0.0333333333333333 0.300435203094778 0.970723648035286 0.999999999999858 GO:0008188 neuropeptide receptor activity 2/2068 48/18639 0.0416666666666667 0.375544003868472 0.975412426330692 0.999999999999858 GO:0015171 amino acid transmembrane transporter activity 6/2068 102/18639 0.0588235294117647 0.530179770167255 0.975717854043422 0.999999999999858 GO:0005004 GPI-linked ephrin receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0005008 hepatocyte growth factor receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0005009 insulin receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0005011 macrophage colony-stimulating factor receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0005020 stem cell factor receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0008288 boss receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0036332 placental growth factor receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0038062 protein tyrosine kinase collagen receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0060175 brain-derived neurotrophic factor receptor activity 2/2068 49/18639 0.0408163265306122 0.367879840524217 0.977756016239199 0.999999999999858 GO:0004536 DNA nuclease activity 3/2068 64/18639 0.046875 0.422487004352031 0.978406425195022 0.999999999999858 GO:0019199 transmembrane receptor protein kinase activity 4/2068 78/18639 0.0512820512820513 0.462208004761196 0.978873586502966 0.999999999999858 GO:0015291 secondary active transmembrane transporter activity 22/2068 287/18639 0.0766550522648084 0.690896285862555 0.979341399097892 0.999999999999858 GO:0019239 deaminase activity 1/2068 33/18639 0.0303030303030303 0.273122911904343 0.979439939757768 0.999999999999858 GO:0005006 epidermal growth factor receptor activity 2/2068 50/18639 0.04 0.360522243713733 0.979882549884931 0.999999999999858 GO:0005007 fibroblast growth factor receptor activity 2/2068 50/18639 0.04 0.360522243713733 0.979882549884931 0.999999999999858 GO:0005017 platelet-derived growth factor receptor activity 2/2068 50/18639 0.04 0.360522243713733 0.979882549884931 0.999999999999858 GO:0005019 platelet-derived growth factor beta-receptor activity 2/2068 50/18639 0.04 0.360522243713733 0.979882549884931 0.999999999999858 GO:0046943 carboxylic acid transmembrane transporter activity 13/2068 188/18639 0.0691489361702128 0.623243240462571 0.980121050523977 0.999999999999858 GO:0015370 solute:sodium symporter activity 4/2068 79/18639 0.0506329113924051 0.456357270523713 0.980567960670748 0.999999999999858 GO:0005342 organic acid transmembrane transporter activity 13/2068 189/18639 0.0687830687830688 0.6199456571797 0.981231370292034 0.999999999999858 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/2068 34/18639 0.0294117647058824 0.265089885083627 0.981725127577877 0.999999999999858 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2068 34/18639 0.0294117647058824 0.265089885083627 0.981725127577877 0.999999999999858 GO:0016831 carboxy-lyase activity 1/2068 34/18639 0.0294117647058824 0.265089885083627 0.981725127577877 0.999999999999858 GO:0019825 oxygen binding 1/2068 34/18639 0.0294117647058824 0.265089885083627 0.981725127577877 0.999999999999858 GO:0005010 insulin-like growth factor receptor activity 2/2068 51/18639 0.0392156862745098 0.353453180111503 0.981811313737398 0.999999999999858 GO:0005021 vascular endothelial growth factor receptor activity 2/2068 51/18639 0.0392156862745098 0.353453180111503 0.981811313737398 0.999999999999858 GO:0005030 neurotrophin receptor activity 2/2068 51/18639 0.0392156862745098 0.353453180111503 0.981811313737398 0.999999999999858 GO:0004497 monooxygenase activity 6/2068 106/18639 0.0566037735849057 0.510172986387358 0.981928300968972 0.999999999999858 GO:0140375 immune receptor activity 10/2068 156/18639 0.0641025641025641 0.577760005951495 0.983286174104967 0.999999999999858 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/2068 132/18639 0.0606060606060606 0.546245823808687 0.98334614822908 0.999999999999858 GO:0005201 extracellular matrix structural constituent 11/2068 168/18639 0.0654761904761905 0.590140577507599 0.983500865873266 0.999999999999858 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/2068 52/18639 0.0384615384615385 0.346656003570897 0.983559989070832 0.999999999999858 GO:0003777 microtubule motor activity 3/2068 68/18639 0.0441176470588235 0.397634827625441 0.984998931167216 0.999999999999858 GO:0005003 ephrin receptor activity 2/2068 53/18639 0.0377358490566038 0.340115324258239 0.985144770537903 0.999999999999858 GO:0005005 transmembrane-ephrin receptor activity 2/2068 53/18639 0.0377358490566038 0.340115324258239 0.985144770537903 0.999999999999858 GO:0008146 sulfotransferase activity 2/2068 53/18639 0.0377358490566038 0.340115324258239 0.985144770537903 0.999999999999858 GO:0038064 collagen receptor activity 2/2068 53/18639 0.0377358490566038 0.340115324258239 0.985144770537903 0.999999999999858 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/2068 53/18639 0.0377358490566038 0.340115324258239 0.985144770537903 0.999999999999858 GO:0004033 aldo-keto reductase (NADPH) activity 1/2068 36/18639 0.0277777777777778 0.250362669245648 0.985562049828686 0.999999999999858 GO:0051287 NAD binding 2/2068 54/18639 0.037037037037037 0.333816892327531 0.986580478205904 0.999999999999858 GO:0022829 wide pore channel activity 1/2068 37/18639 0.027027027027027 0.243596110617387 0.987167042623089 0.999999999999858 GO:0042805 actinin binding 1/2068 37/18639 0.027027027027027 0.243596110617387 0.987167042623089 0.999999999999858 GO:0008237 metallopeptidase activity 12/2068 184/18639 0.0652173913043478 0.587808006054999 0.987307318347541 0.999999999999858 GO:0008374 O-acyltransferase activity 2/2068 55/18639 0.0363636363636364 0.327747494285212 0.987880663045835 0.999999999999858 GO:0000146 microfilament motor activity 1/2068 38/18639 0.0263157894736842 0.237185686653772 0.98859369329804 0.999999999999858 GO:0140662 ATP-dependent protein folding chaperone 1/2068 40/18639 0.025 0.225326402321083 0.990989002474123 0.999999999999858 GO:0016298 lipase activity 7/2068 130/18639 0.0538461538461538 0.485318404999256 0.992182768320204 0.999999999999858 GO:0016798 hydrolase activity, acting on glycosyl bonds 7/2068 130/18639 0.0538461538461538 0.485318404999256 0.992182768320204 0.999999999999858 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/2068 60/18639 0.0333333333333333 0.300435203094778 0.992746142702474 0.999999999999858 GO:0003730 mRNA 3'-UTR binding 17/2068 262/18639 0.0648854961832061 0.584816616711208 0.996042433358933 0.999999999999858 GO:0003774 cytoskeletal motor activity 8/2068 153/18639 0.0522875816993464 0.471270906815337 0.996315947406768 0.999999999999858 GO:0016500 protein-hormone receptor activity 2/2068 67/18639 0.0298507462686567 0.269046450532637 0.996496590282415 0.999999999999858 GO:0015294 solute:monoatomic cation symporter activity 5/2068 116/18639 0.0431034482758621 0.388493797105316 0.997266570004789 0.999999999999858 GO:0005261 monoatomic cation channel activity 23/2068 341/18639 0.0674486803519062 0.60791873939999 0.997707608698454 0.999999999999858 GO:0015293 symporter activity 7/2068 146/18639 0.0479452054794521 0.432132826369201 0.997727711993997 0.999999999999858 GO:0008083 growth factor activity 8/2068 162/18639 0.0493827160493827 0.445089189770041 0.998141887333667 0.999999999999858 GO:0001216 DNA-binding transcription activator activity 36/2068 491/18639 0.0733197556008147 0.660835069943706 0.998172373425387 0.999999999999858 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 35/2068 484/18639 0.0723140495867769 0.651770585226274 0.998495524827761 0.999999999999858 GO:0008514 organic anion transmembrane transporter activity 16/2068 269/18639 0.0594795539033457 0.536092555708153 0.99876687501518 0.999999999999858 GO:0038024 cargo receptor activity 1/2068 65/18639 0.0153846153846154 0.138662401428359 0.999527791273133 0.999999999999858 GO:0008528 G protein-coupled peptide receptor activity 4/2068 122/18639 0.0327868852459016 0.295510035830929 0.999598320740655 0.999999999999858 GO:0004222 metalloendopeptidase activity 3/2068 110/18639 0.0272727272727273 0.245810620713909 0.999746905602422 0.999999999999858 GO:0001653 peptide receptor activity 4/2068 128/18639 0.03125 0.281658002901354 0.999773831091436 0.999999999999858 GO:0005125 cytokine activity 11/2068 234/18639 0.047008547008547 0.423690671031097 0.999838993598883 0.999999999999858 GO:0005179 hormone activity 4/2068 132/18639 0.0303030303030303 0.273122911904343 0.999846301897797 0.999999999999858 GO:0015081 sodium ion transmembrane transporter activity 6/2068 164/18639 0.0365853658536585 0.329745954616219 0.99985243953868 0.999999999999858 GO:0015103 inorganic anion transmembrane transporter activity 6/2068 165/18639 0.0363636363636364 0.327747494285212 0.999865060928508 0.999999999999858 GO:0005249 voltage-gated potassium channel activity 2/2068 98/18639 0.0204081632653061 0.183939920262109 0.999872706815414 0.999999999999858 GO:0005253 monoatomic anion channel activity 2/2068 103/18639 0.0194174757281553 0.175010797919288 0.999926189321845 0.999999999999858 GO:0046873 metal ion transmembrane transporter activity 27/2068 450/18639 0.06 0.5407833655706 0.999939254180676 0.999999999999858 GO:0005254 chloride channel activity 1/2068 83/18639 0.0120481927710843 0.108591037263173 0.999943643930721 0.999999999999858 GO:0022843 voltage-gated monoatomic cation channel activity 4/2068 143/18639 0.027972027972028 0.252113457142471 0.999947542270044 0.999999999999858 GO:0005216 monoatomic ion channel activity 26/2068 448/18639 0.0580357142857143 0.523079148245372 0.999967765659972 0.999999999999858 GO:0005244 voltage-gated monoatomic ion channel activity 5/2068 173/18639 0.0289017341040462 0.260492950660212 0.999985421237044 0.999999999999858 GO:0022832 voltage-gated channel activity 5/2068 175/18639 0.0285714285714286 0.257515888366952 0.999987980843251 0.999999999999858 GO:0030594 neurotransmitter receptor activity 1/2068 97/18639 0.0103092783505155 0.0929181040499312 0.99998922929739 0.999999999999858 GO:0015108 chloride transmembrane transporter activity 2/2068 121/18639 0.0165289256198347 0.148976133766005 0.999989798877587 0.999999999999858 GO:0015079 potassium ion transmembrane transporter activity 4/2068 160/18639 0.025 0.225326402321083 0.99999035302199 0.999999999999858 GO:0005267 potassium channel activity 2/2068 124/18639 0.0161290322580645 0.145371872465215 0.999992681591044 0.999999999999858 GO:0008509 monoatomic anion transmembrane transporter activity 3/2068 149/18639 0.0201342281879195 0.181470928043825 0.999995567404065 0.999999999999858 GO:0003823 antigen binding 3/2068 174/18639 0.0172413793103448 0.155397518842126 0.999999692598665 0.999999999999858 GO:0099094 ligand-gated monoatomic cation channel activity 1/2068 136/18639 0.00735294117647059 0.0662724712709068 0.999999893556527 0.999999999999858 GO:0015276 ligand-gated monoatomic ion channel activity 1/2068 186/18639 0.00537634408602151 0.0484572908217383 0.999999999718245 0.999999999999858 GO:0022836 gated channel activity 7/2068 318/18639 0.0220125786163522 0.198400605817306 0.999999999724757 0.999999999999858 GO:0022834 ligand-gated channel activity 1/2068 188/18639 0.00531914893617021 0.04794178772789 0.999999999777859 0.999999999999858 GO:0045182 translation regulator activity 9/2068 356/18639 0.0252808988764045 0.227858159650534 0.999999999788541 0.999999999999858 GO:0030371 translation repressor activity 4/2068 329/18639 0.0121580547112462 0.10958122909232 0.999999999999858 0.999999999999858