category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/455	101/9376	4.48856490044609	CXCL8/SERPINE1/COL1A1/VCAM1/MMP2/CCL2/FN1/PIM1/VEGFC/CDC42/FOXO1/EDN1/IL1B/BCL2/EGR1/STAT1/TGFB1/NFKB1/VEGFA/COL1A2/NOX4/DIAPH1	7.96040385766789
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/455	82/9376	4.52339855266684	B2M/CTSS/HLA-B/HSPA1A/HLA-DRB5/HSPA6/HLA-A/HSP90AA1/HSPA1B/HLA-DRA/HLA-C/CD74/HLA-DQA2/IFI30/HLA-DPA1/HLA-E/KLRC1/HLA-DPB1	7.2368893188701
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/455	233/9376	2.74164976654247	VIM/DCN/ACTG2/CSRP1/SGCD/ACTB/MYL9/THBS2/PDLIM4/COL1A1/ITGA11/ITGB1/FN1/FHL1/ITGA5/PDLIM2/TPM2/ANK2/ITGB5/DMD/SSPN/DAAM1/FBLN1/THBS1/ELN/ITGA7/COL1A2/TPM1/LMNA/PDLIM1/DIAPH1	6.07965581410579
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	28/455	203/9376	2.84228874573702	TNC/EMP1/ACTB/MYL9/THBS2/COL1A1/ITGA11/ITGB1/PDGFRA/FN1/IGF1/EGFR/VEGFC/ITGA5/CAPN2/CDC42/ITGB5/BIRC3/BCL2/PDGFD/THBS1/FYN/BRAF/ACTN1/ITGA7/VEGFA/COL1A2/DIAPH1	5.99286629118507
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/455	70/9376	4.41569858712716	SGCD/HLA-B/ACTB/HLA-DRB5/CD55/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/HLA-DPA1/HLA-E/DMD/SSPN/HLA-DPB1/FYN	6.47786067219467
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/455	119/9376	3.4632930095115	CXCL2/NFKBIA/TNFAIP3/CREB5/VCAM1/IRF1/CCL2/CCL5/CREB3L1/VEGFC/JUNB/MAP3K8/BIRC3/EDN1/IL1B/MAP3K5/ADAM17/IL15/NFKB1/MAP2K3	6.1071556679521
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/455	45/9376	5.49509157509157	HLA-B/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/GZMB/HLA-DPA1/HLA-E/KLRC1/IL1B/HLA-DPB1	6.82598410632066
NA	NA	hsa04518	Integrin signaling	23/455	154/9376	3.07760810617953	TNC/ACTB/THBS2/COL1A1/ITGA11/VCAM1/ITGB1/PDGFRA/FN1/IGF1/EGFR/VEGFC/ITGA5/CDC42/ITGB5/ITGAX/PDGFD/THBS1/TGFB1/ACTN1/ITGA7/VEGFA/COL1A2	5.8707826140562
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/455	95/9376	3.6874956622325	CXCL8/CXCL2/HLA-DRB5/ATP6V0C/CXCL12/HLA-DRA/CTSK/HLA-DQA2/CCL2/TNFSF13B/CCL5/HLA-DPA1/IL1B/HLA-DPB1/IL15/TGFB1/VEGFA	5.94561460920495
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/455	155/9376	2.92480680609713	CTSS/HLA-B/ACTB/THBS2/HLA-DRB5/ATP6V0C/TUBA4A/HLA-A/HLA-DRA/HLA-C/MRC2/HLA-DQA2/ITGB1/FCGR3B/HLA-DPA1/HLA-E/ITGA5/ITGB5/C1R/HLA-DPB1/CORO1A/THBS1	5.4569321080197
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/455	44/9376	5.15164835164835	HLA-B/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/GZMB/HLA-DPA1/HLA-E/IL1B/HLA-DPB1	6.23367421363711
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/455	204/9376	2.62633053221289	LUM/CD44/DCN/ACTB/PLAUR/COL1A1/MMP2/ITGB1/FN1/IGF1/EGFR/ITGA5/TIMP3/ANK2/FGF2/CDC42/ITGB5/CD63/DDX5/THBS1/WNT4/TGFB1/BRAF/VEGFA/COL1A2/HCLS1	5.30366937643997
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/455	112/9376	3.31177394034537	HSPA1A/NFKBIA/HLA-DRB5/HSPA6/HSPA1B/HLA-DRA/HLA-DQA2/ITGB1/PPIF/HLA-DPA1/BIRC3/BCL2/HLA-DPB1/STAT1/LY96/TGFB1/NFKB1/MAP2K3	5.55827037671558
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/455	160/9376	2.83340659340659	HLA-B/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/VCAM1/HLA-DQA2/ITGB1/ALCAM/CDH2/HLA-DPA1/HLA-E/PTPRM/PTPRC/HLA-DPB1/NRXN3/SLITRK4/JAM2/NCAM2/NEGR1/NEO1/VSIR	5.2824100920382
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/455	39/9376	5.28374189912651	HLA-B/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/GZMB/HLA-DPA1/HLA-E/HLA-DPB1	6.05391734406459
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/455	180/9376	2.63306471306471	B2M/HLA-B/NFKBIA/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/CD74/TNFSF14/HLA-DQA2/CCL2/CCL5/HLA-DPA1/HLA-E/ITGA5/BIRC3/IL1B/BCL2/HLA-DPB1/BST2/STAT1/NFKB1/ZC3HAV1	4.99602649491935
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/455	99/9376	3.33035853035853	SGCD/ACTB/ITGA11/ITGB1/IGF1/ITGA5/TPM2/ITGB5/DMD/EDN1/SSPN/TGFB1/CACNB2/ITGA7/TPM1/LMNA	5.26406361627631
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	32/455	300/9376	2.19803663003663	JUND/HSPA1A/HSPA6/HSPA1B/FGF7/PDGFRA/ANGPT2/DUSP1/GADD45B/IGF1/EGFR/RELB/VEGFC/MAP3K8/FGF2/CDC42/IL1B/PDGFD/FGF1/PTPN7/DUSP6/MAP3K5/DUSP2/TGFB1/GDNF/BRAF/NFKB1/EREG/STK4/CACNB2/VEGFA/MAP2K3	4.76286253805864
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	36/455	362/9376	2.04927448242365	TNC/THBS2/F2R/CREB5/HSP90AA1/COL1A1/ITGA11/FGF7/ITGB1/PDGFRA/ANGPT2/CREB3L1/FN1/IGF1/MCL1/EGFR/VEGFC/ITGA5/GNG10/FGF2/ITGB5/BCL2/PDGFD/FGF1/CSF3R/IL7R/THBS1/DDIT4/GDNF/NFKB1/EREG/ITGA7/PRL/VEGFA/COL1A2/IL7	4.59800232476965
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	27/455	238/9376	2.33772278142026	CXCL8/NFKBIA/CFD/RPL7A/RPS18/C1S/CCL2/C5AR1/RPS25/RPS9/EGFR/RPL37/RPL39/RPL17/RPS21/IL1B/C1R/NRP1/MX2/RPS17/RPL28/ADAM17/STAT1/CASP1/NFKB1/RPS28/RPL36	4.72077815179434
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/455	105/9376	3.14005232862376	CXCL8/CXCL2/NFKBIA/TNFAIP3/CXCL12/BCL2A1/VCAM1/TNFSF14/TNFSF13B/GADD45B/RELB/BIRC3/IL1B/BCL2/LY96/NFKB1	4.98012586132626
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/455	105/9376	3.14005232862376	SGCD/ACTB/ITGA11/ITGB1/IGF1/ITGA5/TPM2/ITGB5/DMD/SSPN/PLN/TGFB1/CACNB2/ITGA7/TPM1/LMNA	4.98012586132626
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/455	100/9376	3.09098901098901	CD44/HLA-DRB5/CD55/HLA-DRA/HLA-DQA2/CD37/CD59/HLA-DPA1/ITGA5/IL1B/CD7/HLA-DPB1/CSF3R/IL7R/IL7	4.74740133177283
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/455	137/9376	2.70743563006337	CTSS/ACTB/NFKBIA/TUBA4A/BCL2A1/CTSK/GZMB/GADD45B/MCL1/CTSW/CAPN2/BIRC3/BCL2/TNFRSF10B/MAP3K5/NFKB1/ERN1/LMNA	4.54649488397468
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/455	34/9376	4.8486102133161	NR1D1/BHLHE40/NPAS2/RORB/RORA/NR1D2/DBP/PER2	5.07701003634979
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/455	181/9376	2.39082022949426	CTSS/HLA-DRB5/ATP6V0C/HLA-DRA/CD74/MRC2/HLA-DQA2/FCGR3B/SPHK1/HLA-DPA1/ITGAX/IL1B/BCL2/HLA-DPB1/LSP1/CORO1A/STAT1/TGFB1/NFKB1/VDR/RIPK2	4.26696407462759
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/455	54/9376	3.81603581603582	HLA-B/HLA-DRB5/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/GZMB/HLA-DPA1/HLA-E/HLA-DPB1	4.68667751873513
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/455	253/9376	2.11767363071711	CD44/CXCL8/ACTB/MYL9/NFKBIA/ITGB1/UBE2D1/CCL5/EGFR/ITGA5/CAPN2/SQSTM1/CDC42/FOXO1/ARF6/IL1B/BCL2/FNBP1/TIFA/CASP1/ACTN1/NFKB1/UBE2V1/RIPK2/DIAPH1/HCLS1	4.06996800119224
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/455	86/9376	3.11495016611296	SGCD/ACTB/ITGA11/ITGB1/CDH2/ITGA5/GJA1/ITGB5/DMD/SSPN/CACNB2/ITGA7/LMNA	4.44965227982445
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/455	187/9376	2.31410941999177	CXCL8/CXCL2/NFKBIA/TNFAIP3/HSP90AA1/CARD16/TXN/CCL2/CCL5/GABARAP/GBP2/BIRC3/IL1B/BCL2/PANX1/STAT1/GPSM3/CASP1/NFKB1/NAMPT/RIPK2	4.0992345909754
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/455	88/9376	3.04415584415584	SERPINE1/F2R/CFD/CD55/PLAUR/C1S/CLU/C5AR1/SERPINB2/CD59/SERPINE2/ITGAX/C1R	4.35089700164604
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/455	78/9376	3.17024513947591	NFKBIA/HLA-DRB5/HLA-DRA/HLA-DQA2/ITGB1/FCGR3B/HLA-DPA1/IL1B/HLA-DPB1/STAT1/TGFB1/NFKB1	4.34656210668196
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/455	138/9376	2.5384933906673	CXCL8/ACTB/NFKBIA/NFATC2/CCL2/ITGB1/FN1/ITGA5/CDC42/ARF6/IL1B/FYB1/CASP1/NFKB1/WIPF3/PTK2B/MAP2K3	4.1117884849013
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/455	142/9376	2.46698653459217	JUND/NFKBIA/NFATC2/TYROBP/CTSK/MITF/FCGR3B/RELB/JUNB/FOSL2/SQSTM1/IL1B/FOSL1/STAT1/TGFB1/FYN/NFKB1	3.97795559987324
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/455	224/9376	2.11585557299843	B2M/HLA-B/NFKBIA/HLA-DRB5/CREB5/HLA-A/HLA-DRA/NFATC2/HLA-C/HLA-DQA2/ZFP36/CREB3L1/HLA-DPA1/HLA-E/RELB/NRP1/HLA-DPB1/FOSL1/EGR1/IL15/CDKN2A/TGFB1/NFKB1	3.81731990663588
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/455	50/9376	3.70918681318681	HLA-DRB5/CXCL12/HLA-DRA/HLA-DQA2/TNFSF13B/HLA-DPA1/HLA-DPB1/IL15/TGFB1	4.33771302472264
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/455	173/9376	2.26315187702471	CXCL8/ACTB/NFKBIA/HLA-DRB5/HLA-DRA/HLA-DQA2/CCL2/CCL5/HLA-DPA1/DNAJB1/IL1B/MX2/HLA-DPB1/TNFRSF10B/STAT1/CASP1/NFKB1/NXT1/IL33	3.78702767737452
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/455	73/9376	3.10510311606202	MITF/FGF7/PDGFRA/GADD45B/IGF1/EGFR/FGF2/PDGFD/FGF1/CDKN2A/BRAF	4.07763042011617
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/455	201/9376	2.15292766934558	CXCL8/REL/BCL2A1/ZEB1/MITF/NUPR1/GZMB/GADD45B/IGF1/MLF1/FOXO1/BIRC3/NFKBIZ/DDX5/HMGA2/DUSP6/ID2/NFKB1/RUNX1/BCL6/PER2	3.73148432088504
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/455	109/9376	2.64671841919548	NFKBIA/HLA-DRB5/HSP90AA1/HLA-DRA/NFATC2/HLA-DQA2/HLA-DPA1/IL1B/HLA-DPB1/STAT1/TGFB1/RORA/NFKB1/RUNX1	3.90523863858678
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/455	216/9376	2.0988196988197	SOD2/CXCL8/HSPA1A/CXCL2/NFKBIA/HSPA6/HSP90AA1/HSPA1B/NFATC2/VCAM1/CCL2/CCL5/CDC42/IL1B/BCL2/TNFRSF10B/MAP3K5/LY96/CASP1/NFKB1/ERN1/MAP2K3	3.68969223379882
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/455	42/9376	3.9250654107797	FTH1/SAT1/SLC3A2/FTL/GPX4/ACSL1/PRNP/ACSL3	4.2905295365608
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	21/455	205/9376	2.11091932457786	VIM/CD44/B2M/HLA-B/NFKBIA/HLA-DRB5/TNFAIP3/HLA-A/HLA-DRA/HLA-C/HLA-DQA2/GADD45B/HLA-DPA1/HLA-E/RELB/RUNX3/BCL2/HLA-DPB1/STAT1/NFKB1/MAP2K3	3.63191496813205
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/455	89/9376	2.77841708852945	CD44/TNC/THBS2/COL1A1/ITGA11/ITGB1/FN1/ITGA5/ITGB5/THBS1/ITGA7/COL1A2	3.80693507434611
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/455	66/9376	3.12221112221112	HLA-DRB5/HLA-DRA/HLA-DQA2/HLA-DPA1/IL1B/HLA-DPB1/STAT1/TGFB1/RORA/NFKB1	3.90724172799457
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/455	298/9376	1.86704034220813	CXCL8/CXCL2/CXCL12/IL32/TNFSF14/CCL2/XCL1/BMP8A/TNFSF13B/XCL2/CCL5/TNFRSF12A/IL34/ACVRL1/IL1B/TNFRSF10B/CSF3R/IL7R/IL15/TNFRSF18/CXCL13/TGFB1/IL33/PRL/INHBA/IL7/INHBB	3.43508046591767
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/455	56/9376	3.31177394034537	CXCL8/HSPA1A/CXCL2/NFKBIA/HSPA6/HSPA1B/IL1B/CASP1/NFKB1	3.91846514438168
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/455	227/9376	1.99711477949363	CXCL8/B2M/HLA-B/NFKBIA/CREB5/CXCL12/HLA-A/NFATC2/HLA-C/CCL2/PDGFRA/CCL5/CREB3L1/HLA-E/EGFR/GNG10/IL1B/CDKN2A/NFKB1/VEGFA/PTK2B/PTGER3	3.43443922152595
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/455	130/9376	2.37768385460693	ACTA2/NFKBIA/CREB5/COL1A1/MMP2/CREB3L1/EGFR/VEGFC/GNG10/EDN1/TGFB1/NFKB1/RXFP1/VEGFA/COL1A2	3.57214325537885
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/455	106/9376	2.52722371967655	NFKBIA/CREB5/HSP90AA1/ZEB1/PDGFRA/CREB3L1/IGF1/EGFR/FOXO1/BCL2/PDGFD/BRAF/NFKB1	3.57108586712233
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/455	94/9376	2.63062894552256	S100A8/CXCL8/JUND/S100A9/CXCL2/NFKBIA/TNFAIP3/HSP90AA1/CCL2/IL1B/FOSL1/NFKB1	3.58825136621611
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/455	133/9376	2.32405188796166	HLA-B/HLA-A/NFATC2/TYROBP/HLA-C/FCGR3B/GZMB/CD48/HLA-E/KLRC1/TNFRSF10B/FYN/BRAF/PTK2B/HCST	3.47303304646317
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/455	232/9376	1.9540735126942	TMSB4X/ACTB/MYL9/F2R/CXCL12/ITGA11/FGF7/ITGB1/PDGFRA/FN1/EGFR/ITGA5/FGF2/CDC42/ITGB5/ITGAX/PDGFD/FGF1/BRAF/ACTN1/ITGA7/DIAPH1	3.32309142360071
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/455	71/9376	2.9023370995202	CXCL8/CXCL2/NFKBIA/ATP6V0C/CCL5/EGFR/CDC42/ADAM17/NFKB1/JAM2	3.63364947437351
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	23/455	248/9376	1.91109535625665	CXCL8/ACTB/MYL9/NFKBIA/TUBA4A/HSP90AA1/TXN/S100A10/PTPRC/CDC42/BIRC3/ARF6/IL1B/BCL2/TNFRSF10B/RHOJ/AHNAK2/LY96/CASP1/NFKB1/PODXL/RIPK2/MAP2K3	3.28387354226229
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/455	50/9376	3.29705494505495	CXCL8/THBS2/VCAM1/CCL2/HBA2/IL1B/THBS1/TGFB1	3.67784351568867
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/455	41/9376	3.51819887429644	CXCL8/MMP2/EGFR/THBS1/CDKN2A/BRAF/VEGFA	3.6492982555629
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/455	142/9376	2.17675282464015	ACTB/HSP90AA1/TXN/VCAM1/MGST1/MMP2/CCL2/DUSP1/SQSTM1/EDN1/IL1B/BCL2/MAP3K5/NFKB1/VEGFA	3.19094305098397
Human Diseases	Immune disease	hsa05310	Asthma	6/455	32/9376	3.86373626373626	HLA-DRB5/PRG2/HLA-DRA/HLA-DQA2/HLA-DPA1/HLA-DPB1	3.66459648057008
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/455	157/9376	2.10003499685028	CXCL8/HLA-B/SERPINE1/ZFP36L2/HLA-A/NFATC2/HLA-C/GADD45B/HLA-E/CAPN2/SQSTM1/FOXO1/CDKN2A/TGFB1/NFKB1/MAP2K3	3.13905545239886
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/455	78/9376	2.64187094956326	CXCL8/C1S/IRF1/ITGB1/ITGA5/IL1B/C1R/LY96/CASP1/NFKB1	3.28833546202848
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/455	174/9376	2.01328786156372	HSPA1A/HSPA6/HSP90AA1/HSPA1B/CRYAB/PPP1R15A/UBE2D1/DNAJA1/CAPN2/DNAJB1/HSPH1/BCL2/MAP3K5/PRKN/KRTCAP2/ERN1/SSR3	3.04684889683199
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	27/455	333/9376	1.67080487080487	TNC/HLA-B/THBS2/CREB5/ATP6V0C/HLA-A/COL1A1/HLA-C/ITGA11/IRF1/ITGB1/CREB3L1/FN1/HLA-E/EGFR/ITGA5/CDC42/ITGB5/FOXO1/MX2/THBS1/STAT1/WNT4/NFKB1/ITGA7/VEGFA/COL1A2	2.8147940581777
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/455	110/9376	2.24799200799201	DCN/EMP3/THSD4/BMP8A/LTBP1/THBS1/TGFB1/ID2/NEO1/RGMB/INHBA/INHBB	2.97335363977127
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/455	212/9376	1.84681733360979	ACTB/F2R/FGF7/ITGB1/PDGFRA/ANGPT2/IGF1/EGFR/VEGFC/FGF2/CDC42/PDGFD/FGF1/FYB1/THBS1/BRAF/EVL/VEGFA/MAP2K3	2.81643476286329
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/455	99/9376	2.28962148962149	HLA-DRB5/CFD/HLA-DRA/C1S/HLA-DQA2/FCGR3B/C5AR1/HLA-DPA1/KRT17/C1R/HLA-DPB1	2.91313524242988
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/455	100/9376	2.26672527472527	CXCL8/CXCL2/CXCL12/TNFSF14/CCL2/XCL1/XCL2/CCL5/IL34/TNFRSF10B/CXCL13	2.87598510782067
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/455	75/9376	2.47279120879121	SERPINE1/GADD45B/IGF1/ZMAT3/BCL2/TNFRSF10B/THBS1/CDKN2A/TP53I3	2.8919551907236
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/455	77/9376	2.40856286570572	GADD45B/EGFR/CDC42/STAT1/CDKN2A/TGFB1/BRAF/NFKB1/VEGFA	2.80277374360066
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/455	133/9376	2.01417830290011	SOD2/GADD45B/HOMER1/IGF1/EGFR/GABARAP/FOXO1/IL7R/TGFB1/BRAF/STK4/BCL6/DEPP1	2.66022411432866
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/455	93/9376	2.21576273189176	NFKBIA/HLA-DRB5/HLA-DRA/NFATC2/HLA-DQA2/HLA-DPA1/RUNX3/HLA-DPB1/STAT1/NFKB1	2.66091310386858
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	22/455	275/9376	1.64852747252747	HSPA1A/CREB5/TUBA4A/HSPA6/HSPA1B/MT-ND3/NDUFA4/CCL5/CREB3L1/PPIF/PSMB3/ATP5F1E/MT-CO2/MT-ND4/IL1B/MT-ND2/EGR1/MT-CYB/FYN/PRNP/NCAM2/PSMD9	2.46510109555116
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/455	110/9376	2.06065934065934	SERPINE1/TIMP1/ANGPT2/LDHA/IGF1/EGFR/EDN1/BCL2/PFKP/NFKB1/VEGFA	2.52703165638145
NA	NA	hsa04517	IgSF CAM signaling	23/455	299/9376	1.58512256973795	ACTB/MYL9/TUBA4A/ITGB1/CDH2/CD48/SORBS1/NRP2/ITGA5/ANK2/CDC42/FOXO1/ITGAX/ARF6/NRP1/PPFIA2/SLITRK4/FYN/ACTN1/CLMP/JAM2/NCAM2/MYL6	2.32217980364042
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	20/455	254/9376	1.62256640996798	F2R/NFATC2/FGF7/PDGFRA/SPHK1/PPIF/EGFR/VEGFC/ATP2B1/HRH1/FGF2/PDGFD/FGF1/ASPH/PLN/GDNF/PDE1C/VEGFA/PTK2B/PTGER3	2.27165343692055
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/455	115/9376	1.97106545628285	JUND/CREB5/PDE4B/CREB3L1/EGFR/PTHLH/MAFB/BCL2/EGR1/BRAF/VDR	2.36620871814269
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/455	116/9376	1.9540735126942	ACTB/MYL9/CXCL12/THY1/VCAM1/MMP2/ITGB1/CDC42/ACTN1/JAM2/PTK2B	2.33501624903885
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/455	103/9376	2.00064013656247	CXCL8/CXCL2/COL1A1/FN1/IL1B/TGFB1/ACTN1/NFKB1/COL1A2/SERPINB9	2.30606194014908
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/455	196/9376	1.68217089033416	CXCL8/CLEC2B/HLA-B/CXCL2/NFKBIA/HLA-A/NFATC2/HLA-C/ANGPT2/ZFP36/HLA-E/GNG10/FGF2/STAT1/NFKB1/VEGFA	2.17963837291476
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/455	62/9376	2.32655086848635	SOD2/HSPA1A/HSPA6/HSPA1B/CRYAB/IGF1/FOXO1	2.3666618116165
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/455	168/9376	1.71721611721612	FTH1/TNFAIP3/HSP90AA1/CAPN2/GLUL/SQSTM1/BIRC3/IL1B/BCL2/TNFRSF10B/FTL/STAT1/CASP1/IL33	2.11839329334594
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/455	109/9376	1.8905131565682	CXCL8/NFKBIA/CTSK/CCL5/MAP3K8/IL1B/STAT1/LY96/NFKB1/MAP2K3	2.11187677666171
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/455	80/9376	2.06065934065934	PDGFRA/IGF1/EGFR/FGF2/BCL2/PDGFD/BRAF/VEGFA	2.15157962885955
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/455	323/9376	1.46734256455619	VIM/CD44/TNC/ZEB1/PDGFRA/MCL1/PIM1/EGFR/ITGA5/TIMP3/BCL2/FOXP1/HMGA2/THBS1/CDKN2A/DDIT4/NFKB1/VEGFA/SOX4/TPM1/SLC7A1/ZFPM2/RECK	1.93030042038522
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/455	68/9376	2.12126696832579	BCL2A1/PIM1/DUSP6/BRAF/NFKB1/RUNX1/PER2	2.09565536845375
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/455	193/9376	1.601548710357	CXCL8/CXCL2/NFKBIA/CXCL12/CCL2/XCL1/XCL2/CCL5/GNG10/CDC42/CXCL13/STAT1/BRAF/NFKB1/PTK2B	1.9069606401049
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	17/455	227/9376	1.54322505688144	SOD2/NFKBIA/MGST1/MT-ND3/NDUFA4/PPIF/EGFR/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/MAP3K5/MT-CYB/BRAF/NFKB1/VEGFA/NOX4	1.87107189647389
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	13/455	163/9376	1.64347063978966	CXCL8/NFKBIA/CREB5/NFATC2/CREB3L1/BCL2/DDX3X/STAT1/TGFB1/BRAF/NFKB1/PTK2B/MAP2K3	1.87157212923408
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/455	134/9376	1.69158602591438	ACTA2/ACTG2/MYL9/RAMP1/KCNMB1/EDN1/KCNMA1/KCNMB4/ADM/BRAF/MYL6	1.8209591083214
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/455	200/9376	1.54549450549451	CXCL8/ACTB/NFKBIA/F2R/TUBA4A/ITGB1/CDC42/ARF6/IL1B/TNFRSF10B/FYN/CASP1/NFKB1/WIPF3/HCLS1	1.76101576033865
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/455	268/9376	1.46091520419879	TUBA4A/TXN/MT-ND3/SNCAIP/MAOB/DUSP1/NDUFA4/PPIF/UCHL1/PSMB3/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/MAP3K5/PRKN/MT-CYB/ERN1/PSMD9	1.72886661221591
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/455	73/9376	1.97597471022129	APOBEC3A/BICD1/ELL2/MX2/BST2/SUPT4H1/SMARCB1	1.89048419400332
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/455	235/9376	1.49068973579612	ACTB/CREB5/MT-ND3/BMP8A/NDUFA4/CREB3L1/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/MAP3K5/COX16/MT-CYB/ACSL1/SMARCB1/ACSL3/MAP2K3	1.72039676423654
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/455	59/9376	2.09558577016204	ENPP1/NME2/NT5E/UPP1/DPYD/CDA	1.90642141474308
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/455	105/9376	1.76627943485086	NFKBIA/NFATC2/IRF1/RELB/IL1B/LSP1/STAT1/CASP1/NFKB1	1.78321248478881
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/455	238/9376	1.47189952904239	REL/FGF7/PDGFRA/ANGPT2/IGF1/EGFR/VEGFC/GNG10/FGF2/CDC42/RASAL2/ARF6/PDGFD/FGF1/NFKB1/STK4/VEGFA	1.66531737179519
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/455	139/9376	1.63073760771602	HSPA1A/CREB5/HSPA6/HSP90AA1/HSPA1B/MMP2/CREB3L1/EGFR/KRT17/BCL2/GREB1	1.69190206981672
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/455	21/9376	2.94379905808477	ENPP1/DPYD/BCAT1	2.01383407772956
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/455	77/9376	1.87332667332667	NFKBIA/GADD45B/CDKN2A/TGFB1/BRAF/NFKB1/RUNX1	1.73775493389834
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/455	93/9376	1.77261018551341	ACTB/MYL9/SORBS1/EGFR/PTPRM/CDC42/FYN/ACTN1	1.69099488978084
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/455	49/9376	2.10271361291769	B4GALT1/GXYLT2/GALNT10/XXYLT1/GALNT16	1.74773005392442
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/455	144/9376	1.57411477411477	CXCL8/CXCL2/NFKBIA/C5AR1/FOXO1/IL1B/MAP3K5/LY96/NFKB1/NOX4/MAP2K3	1.56789378285073
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/455	214/9376	1.44438738831262	B2M/HLA-B/NFKBIA/APOBEC3A/HLA-A/NFATC2/HLA-C/HLA-E/GNG10/BCL2/BST2/NFKB1/PTK2B/MAP2K3/AP1S2	1.4851079912211
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/455	250/9376	1.40124835164835	CTSS/ATP6V0C/LAMP5/CTSK/LITAF/SLC11A1/MITF/OSBPL1A/CTSW/CD63/OSBPL3/HEXB/LAPTM5/PSAP/IDS/GPR155/AP1S2	1.45220390507777
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/455	149/9376	1.5212921306881	CXCL8/PLPP1/F2R/PDGFRA/SPHK1/AGPAT4/EGFR/ARF6/PDGFD/FYN/PTK2B	1.44853372077553
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/455	38/9376	2.16911509543088	NNMT/ENPP1/NT5E/NAMPT	1.63082251421365
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/455	184/9376	1.45590062111801	MYL9/CXCL12/NFATC2/ITGB1/CDC42/NRP1/SEMA3C/TRPC4/WNT4/FYN/EFNB2/NEO1/ABLIM1	1.41045311527146
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/455	168/9376	1.47189952904239	PDGFRA/MCL1/PIM1/FHL1/EGFR/BCL2/CSF3R/IL7R/IL15/STAT1/PRL/IL7	1.39381808838419
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/455	205/9376	1.40727954971857	HLA-B/NFKBIA/REL/CREB5/HLA-A/HLA-C/CREB3L1/HLA-E/CDC42/DDX3X/CDKN2A/ACTN1/NFKB1/HDAC9	1.33151405337111
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/455	205/9376	1.40727954971857	COL1A1/MMP2/MT-ND3/NDUFA4/PPIF/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/PLN/MT-CYB/TGFB1/NFKB1/COL1A2	1.33151405337111
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/455	136/9376	1.51519069166128	HSPA1A/NFKBIA/TNFAIP3/HSPA6/HSPA1B/IL1B/BCL2/MX2/STAT1/NFKB1	1.36674043471363
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/455	103/9376	1.60051210924997	COL12A1/COL15A1/COL1A1/SLC3A2/ELN/COL8A1/COL1A2/COL18A1	1.38393221412977
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/455	103/9376	1.60051210924997	CXCL8/SERPINE1/NFKBIA/CCL2/CCL5/IL1B/TGFB1/NFKB1	1.38393221412977
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/455	55/9376	1.87332667332667	PLPP1/SPHK1/SGMS2/HEXB/PSAP	1.46693672815331
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/455	157/9376	1.44377406033457	NFATC2/SPHK1/ITGB5/ANO4/PANX1/DUSP2/ADAM17/THBS1/TGFB1/CASP1/MFGE8	1.26635187763577
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/455	157/9376	1.44377406033457	ACTB/SERPINE1/FRMD6/BMP8A/CCN2/BIRC3/FGF1/WNT4/TGFB1/GLI2/ID2	1.26635187763577
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	16/455	250/9376	1.31882197802198	HLA-B/HSPA1A/HSPA6/HLA-A/HSPA1B/HLA-C/PDGFRA/HLA-E/EGFR/CDC42/ARF6/ASAP2/EHD4/WIPF3/RAB31/VPS37B	1.15388516764275
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/455	76/9376	1.62683632157316	PDGFRA/GADD45B/IGF1/EGFR/CDKN2A/BRAF	1.23909339539007
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/455	15/9376	2.74754578754579	ST6GALNAC5/HEXB	1.52966960528772
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/455	93/9376	1.55103391232423	NFKBIA/ITGB1/GADD45B/FN1/BIRC3/BCL2/NFKB1	1.20603578273698
NA	NA	hsa04382	Cornified envelope formation	14/455	217/9376	1.32945763913506	S100A6/S100A4/S100A8/S100A9/S100A12/S100A16/S100A10/KRT17/S100A3/KRT6A/S100A11/SPRR3/KRT86/S100A13	1.1088938790868
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/455	61/9376	1.68906503332733	FTH1/ATP2B1/HEPH/FTL/VDR	1.21932159886308
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/455	78/9376	1.58512256973795	ACTB/ITGB1/FN1/ITGA5/CDC42/HCLS1	1.17188217272153
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	28/455	480/9376	1.20205128205128	DKK1/TUBA4A/MT-ND3/SNCAIP/NDUFA4/PPIF/UCHL1/CAPN2/SQSTM1/PSMB3/ATP5F1E/MT-CO2/MT-ND4/IL1B/BCL2/MT-ND2/MAP3K5/PRKN/MT-CYB/WNT4/BRAF/PRNP/NFKB1/ERN1/GPX1/NOX4/PSMD9/MAP2K3	1.02628837333308
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/455	16/9376	2.57582417582418	MAOB/MIF	1.42467037257395
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/455	166/9376	1.36549715344896	MYL9/CREB5/NFATC2/KCNMB1/CREB3L1/PPIF/ATP2B1/KCNMA1/PLN/RGS2/KCNMB4	1.07298288516303
Genetic Information Processing	Translation	hsa03010	Ribosome	14/455	222/9376	1.2995148995149	RPL7A/RPS18/RPS25/RPS9/RPL37/RPL39/RPL17/RPS21/RPS17/RPL28/MRPS24/MRPL23/RPS28/RPL36	1.01993860781299
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/455	98/9376	1.47189952904239	PLPP1/FCGR3B/SPHK1/PTPRC/CDC42/ARF6/ASAP2	1.06052268947207
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/455	17/9376	2.42430510665805	GLUL/CA5B	1.32738631323666
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/455	17/9376	2.42430510665805	NRP2/PCDH7	1.32738631323666
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/455	170/9376	1.33336780866193	ACTB/MYL9/TUBA4A/ITGB1/CDC42/MAP3K5/ACTN1/JAM2/RUNX1/MYL6/HCLS1	0.990597442840721
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/455	226/9376	1.27651463580667	MYL9/NFKBIA/F2R/CREB5/PDE4B/CREB3L1/ATP2B1/EDN1/HCAR3/PLN/BRAF/PDE10A/NFKB1/PTGER3	0.950268564288555
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/455	49/9376	1.68217089033416	CREB5/MAOB/CREB3L1/NFKB1	1.08119692455304
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/455	83/9376	1.48963325830796	NFKBIA/CCL5/IL1B/CASP1/NFKB1/IL33	1.0118509738873
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/455	18/9376	2.28962148962149	ACSL1/ACSL3	1.23677745611392
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/455	120/9376	1.37377289377289	NFKBIA/ARHGDIB/CDC42/BCL2/MAP3K5/BRAF/NFKB1/RIPK2	0.930617724425149
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/455	157/9376	1.31252187303143	CXCL8/NDUFA4/CDC42/MT-CO2/IL1B/MAP3K5/MT-CYB/TGFB1/NFKB1/ERN1	0.89181116268315
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/455	19/9376	2.16911509543088	HEXB/IDS	1.15199427465109
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/455	104/9376	1.38698224852071	PLPP1/AGPAT4/SGMS2/PLPP4/GPAT3/CHPT1/PEMT	0.896201298298059
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/455	87/9376	1.42114437286851	TPM2/MT-CO2/ASPH/MT-CYB/CACNB2/TPM1	0.89123188166662
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/455	87/9376	1.42114437286851	GADD45B/EGFR/BCL2/TGFB1/BRAF/EREG	0.89123188166662
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/455	178/9376	1.273441165576	DKK1/NFATC2/SFRP2/ROR2/SERPINF1/DAAM1/FOSL1/APCDD1L/WNT4/SFRP4/NOTUM	0.831786298056398
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	22/455	388/9376	1.16841509006457	DKK1/TUBA4A/MT-ND3/NDUFA4/PPIF/CAPN2/PSMB3/ATP5F1E/MT-CO2/MT-ND4/IL1B/MT-ND2/MAP3K5/ADAM17/MT-CYB/WNT4/APOE/BRAF/NFKB1/ERN1/NOX4/PSMD9	0.765155844094911
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/455	143/9376	1.29691846614924	HLA-DRB5/HLA-DRA/C1S/HLA-DQA2/FCGR3B/HLA-DPA1/C1R/HLA-DPB1/ACTN1	0.808013052153026
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/455	71/9376	1.4511685497601	PDGFRA/SLC7A5/LDHA/EGFR/PFKP	0.861775951330143
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/455	37/9376	1.67080487080487	VCAM1/HBA2/IL1B	0.923275791887354
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/455	90/9376	1.37377289377289	SOD2/CREB5/CREB3L1/IGF1/FOXO1/NFKB1	0.804635676648888
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/455	90/9376	1.37377289377289	NFKBIA/NFATC2/EGFR/STAT1/NFKB1/MAP2K3	0.804635676648888
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/455	21/9376	1.96253270538985	CHSY3/CHST7	0.997212728847184
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/455	73/9376	1.41141050730092	GADD45B/EGFR/CDKN2A/BRAF/STK4	0.796911080946889
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/455	56/9376	1.47189952904239	GAS1/BCL2/GLI2/CDON	0.799871399158721
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/455	93/9376	1.32945763913506	MMP2/EGFR/CDC42/EGR1/PTK2B/MAP2K3	0.721076675693107
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/455	75/9376	1.37377289377289	MGST1/BIRC3/BCL2/MAP3K5/CDKN2A	0.733935980773185
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/455	150/9376	1.2363956043956	FGF7/GADD45B/EGFR/FGF2/BCL2/FGF1/WNT4/TGFB1/BRAF	0.659117538752735
NA	NA	hsa04519	Cadherin signaling	22/455	404/9376	1.12214122511152	VIM/CDH13/ACTB/NFKBIA/PDGFRA/CDH2/EGFR/GJA1/FAT3/CDC42/KRT17/PCDH7/DAAM1/KRT6A/LIMA1/WNT4/KRT86/ACTN1/NFKB1/EVL/PTK2B/MAP2K3	0.566751774691368
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/455	59/9376	1.39705718010803	MGST1/GGT5/GPX4/GPX1	0.690916523060981
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/455	308/9376	1.13737690880548	SOD2/CREB5/TUBA4A/MT-ND3/NDUFA4/CREB3L1/PPIF/PSMB3/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/MAP3K5/MT-CYB/ERN1/GPX1/PSMD9	0.553627824794738
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/455	154/9376	1.20428143285286	CREB5/CREB3L1/ATP2B1/TPM2/BCL2/PLN/CREM/CACNB2/TPM1	0.577246440654497
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	20/455	368/9376	1.11992355470616	ACTB/TUBA4A/MT-ND3/NDUFA4/SQSTM1/PSMB3/ATP5F1E/MT-CO2/MT-ND4/BCL2/MT-ND2/MAP3K5/PRKN/MT-CYB/CASP1/NXT1/ERN1/GPX1/PSMD9/MAP2K3	0.530027960598334
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/455	60/9376	1.37377289377289	NFATC2/SPHK1/CDC42/VEGFA	0.655923596963433
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/455	99/9376	1.24888444888445	MMP2/IGF1/EGFR/BCL2/CDKN2A/BRAF	0.562206868583454
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/455	138/9376	1.19458512501991	ATP6V0C/MT-ND3/NDUFA4/ATP5F1E/MT-CO2/MT-ND4/MT-ND2/MT-CYB	0.520049602580941
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/455	44/9376	1.404995004995	B4GALT1/HEXB/KRTCAP2	0.608097484529689
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/455	44/9376	1.404995004995	CREB5/ARHGDIB/CREB3L1	0.608097484529689
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/455	217/9376	1.13953511925862	CREB5/HSP90AA1/FGF7/MGST1/CREB3L1/EGFR/FGF2/BCL2/NFKB1/VDR/VEGFA/BCL6	0.469649573370804
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/455	63/9376	1.30835513692657	PTGDS/GGT5/PTGIS/GPX4	0.554576200346239
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/455	82/9376	1.25649959796301	MGST1/NME2/UPP1/DPYD/CDA	0.526837703156802
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/455	122/9376	1.18234552332913	NFKBIA/NFATC2/PTPRC/MAP3K8/CDC42/FYN/NFKB1	0.457820083496825
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/455	122/9376	1.18234552332913	ACTB/RCAN2/FOXO1/PLN/STAT1/WNT4/PFKP	0.457820083496825
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/455	46/9376	1.3439082656474	FTH1/HEPH/FTL	0.528038118348786
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/455	46/9376	1.3439082656474	PSMB9/PSMB3/PSMD9	0.528038118348786
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/455	65/9376	1.26809805579036	PLPP1/AGPAT4/PLPP4/GPAT3	0.489820262137975
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/455	10/9376	2.06065934065934	SQOR	0.757850272377114
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/455	85/9376	1.21215255332902	ENPP1/NME2/NT5E/UPP1/CDA	0.443722103041213
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/455	28/9376	1.47189952904239	GPHN/GCH1	0.564746794531499
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/455	86/9376	1.19805775619729	CREB5/KCNMB1/CREB3L1/KCNMA1/KCNMB4	0.416694520996635
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/455	148/9376	1.11386991386991	FGF7/GADD45B/IGF1/EGFR/FGF2/FGF1/WNT4/BRAF	0.315333872150786
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/455	30/9376	1.37377289377289	IL1B/NFKB1	0.463063029527411
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/455	89/9376	1.15767378688727	TUBA4A/PDGFRA/EGFR/GJA1/PDGFD	0.33752142479831
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/455	89/9376	1.15767378688727	GABARAP/GLUL/GNG10/SLC38A1/GPHN	0.33752142479831
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/455	50/9376	1.2363956043956	SAT1/P4HA3/MAOB	0.378495970518843
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/455	170/9376	1.09093729799612	ACTB/MGST1/GADD45B/EGFR/CDKN2A/WNT4/TGFB1/BRAF/SMARCB1	0.270218816913893
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/455	70/9376	1.17751962323391	NFKBIA/ACSL1/NFKB1/ACSL3	0.33666535748312
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/455	70/9376	1.17751962323391	CDC42/TGFB1/BRAF/VEGFA	0.33666535748312
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/455	12/9376	1.71721611721612	NCAM2	0.561428593948641
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/455	71/9376	1.16093483980808	IRF1/STAT1/NFKB1/PRL	0.307401246721469
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/455	32/9376	1.28791208791209	B4GALT1/PFKP	0.368428349159386
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/455	32/9376	1.28791208791209	LDHA/SUCLG2	0.368428349159386
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/455	32/9376	1.28791208791209	BIRC3/BCL2	0.368428349159386
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/455	72/9376	1.14481074481074	CXCL8/NFKBIA/DDX3X/NFKB1	0.278558715707507
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/455	116/9376	1.06585827965138	HOMER1/GLUL/GNG10/GRIK2/SLC38A1/DLGAP1	0.161182708746903
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/455	14/9376	1.47189952904239	B4GALT1	0.399037591223334
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/455	76/9376	1.08455754771544	SORBS1/PLIN2/ACSL1/ACSL3	0.167148417056678
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/455	140/9376	1.03032967032967	ACTA2/SERPINE1/CCN2/SPHK1/GNG10/EGR1/APLN	0.0816534073487191
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/455	36/9376	1.14481074481074	ENPP1/GBE1	0.196590789315876
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/455	36/9376	1.14481074481074	GALNT10/GALNT16	0.196590789315876
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/455	99/9376	1.04073704073704	IGF1/HRH1/IL1B/TRPA1/MAP2K3	0.0920211938141681
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/455	99/9376	1.04073704073704	PLPP1/PDGFRA/EGFR/PDGFD/CHPT1	0.0920211938141681
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/455	37/9376	1.11386991386991	MAOB/MIF	0.156727148946078
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/455	37/9376	1.11386991386991	GADD45B/BRAF	0.156727148946078
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/455	122/9376	1.0134390199964	CREB5/CREB3L1/IGF1/JUNB/STAT1/MAP2K3	0.0337417291334351
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/455	16/9376	1.28791208791209	HEXB	0.260295423719927
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/455	59/9376	1.04779288508102	GADD45B/EGFR/BRAF	0.0831640772199304
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/455	38/9376	1.08455754771544	PTPRC/IL7R	0.11795104955874
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/455	125/9376	0.989116483516484	SPHK1/BCL2/SGMS2/MAP3K5/FYN/NFKB1	-0.0276639679146454
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/455	17/9376	1.21215255332902	CYP7B1	0.197716342018821
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/455	17/9376	1.21215255332902	GGT5	0.197716342018821
Organismal Systems	Immune system	hsa04611	Platelet activation	6/455	126/9376	0.981266352694924	ACTB/F2R/COL1A1/ITGB1/FYN/COL1A2	-0.0478102828051572
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/455	18/9376	1.14481074481074	HEXB	0.138876923210671
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/455	128/9376	0.965934065934066	ENPP1/NME2/NT5E/PDE4B/PDE10A/PDE1C	-0.0876366852699303
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/455	63/9376	0.981266352694924	GADD45B/WNT4/GLI2	-0.0336924334863594
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	5/455	107/9376	0.962924925541748	CREB5/CREB3L1/LDHA/FOXO1/PFKP	-0.0871047916951801
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/455	194/9376	0.955975982780106	ACTA2/ACTG2/ACTB/MYL9/TUBA4A/TPM2/KIF13B/TPM1/MYL6	-0.139928589778936
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/455	109/9376	0.945256578284101	NFKBIA/CREB5/CREB3L1/FOXO1/NFKB1	-0.129825550744629
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/455	43/9376	0.958446204957833	ACSL1/ACSL3	-0.0616763770930353
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/455	154/9376	0.936663336663337	ACTB/MYL9/NFATC2/EGFR/RGS2/CACNB2/MYL6	-0.178973012688603
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/455	68/9376	0.909114414996768	ALDH1A3/ALDH1A1/ALDH1A2	-0.169865758563702
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/455	91/9376	0.905784325564545	NFKBIA/NFATC2/IFITM1/NFKB1	-0.203956462270434
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/455	91/9376	0.905784325564545	PDE4B/GNG10/PDE10A/PDE1C	-0.203956462270434
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/455	69/9376	0.895938843764931	EDN1/KCNMA1/PDE1C	-0.195926374563629
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/455	69/9376	0.895938843764931	CREB5/MAOB/CREB3L1	-0.195926374563629
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/455	115/9376	0.895938843764931	CREB5/CREB3L1/GNG10/BCL2/FYN	-0.253567268313691
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/455	22/9376	0.936663336663337	MAOB	-0.0671664515567339
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/455	93/9376	0.886305092756706	LYZ/CST3/ATP2B1/KCNMA1	-0.24884153839463
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/455	23/9376	0.895938843764931	GLUL	-0.112839632941825
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/455	23/9376	0.895938843764931	B4GALT1	-0.112839632941825
NA	NA	hsa03272	Virion - Hepatitis viruses	2/455	48/9376	0.858608058608059	EGFR/CD63	-0.221786738519423
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/455	144/9376	0.858608058608059	IGF1/FGF2/WNT4/ID2/INHBA/INHBB	-0.386138026486844
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/455	144/9376	0.858608058608059	PPIF/PSMB3/MAP3K5/RORA/ERN1/PSMD9	-0.386138026486844
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/455	75/9376	0.824263736263736	GLUL/PFKP/BCAT1	-0.345073624202022
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/455	75/9376	0.824263736263736	CREB5/CREB3L1/GPX1	-0.345073624202022
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/455	122/9376	0.844532516663664	CREB5/CREB3L1/IGF1/FOXO1/PFKP	-0.390336625229955
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/455	51/9376	0.808101702219349	PLPP1/CHPT1	-0.310324709154421
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/455	51/9376	0.808101702219349	ACTB/ATP6V0C	-0.310324709154421
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/455	26/9376	0.792561284868977	BTD	-0.239196736021384
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/455	101/9376	0.816102709172016	MITF/CREB3L1/EDN1/WNT4	-0.419627194877345
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/455	53/9376	0.777607298362015	ATP2B1/VDR	-0.366661398221238
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/455	54/9376	0.763207163207163	LDHA/BCAT1	-0.394090039080806
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/455	28/9376	0.735949764521193	B4GALT1	-0.316002697405849
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/455	28/9376	0.735949764521193	ATP6V0C	-0.316002697405849
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/455	105/9376	0.785013082155939	MITF/GABARAP/SQSTM1/PRKN	-0.500297069880792
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/455	56/9376	0.735949764521193	B4GALT1/KRTCAP2	-0.447566098930462
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/455	29/9376	0.710572186434255	FRMD6	-0.352523203673523
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/455	155/9376	0.797674583481035	CREB5/CREB3L1/EGFR/CDKN2A/WNT4/BRAF	-0.573603573186392
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/455	57/9376	0.723038365143628	ACSL1/ACSL3	-0.473649357926289
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/455	83/9376	0.744816629153979	SOD2/ACSL1/ACSL3	-0.527348863520193
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/455	156/9376	0.792561284868977	NFKBIA/EGFR/MX2/STAT1/BRAF/NFKB1	-0.59002609460624
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/455	30/9376	0.686886446886447	SUCLG2	-0.387912855390073
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/455	158/9376	0.782528863541522	SLC7A5/IGF1/SLC3A2/WNT4/DDIT4/BRAF	-0.622581745067899
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/455	31/9376	0.664728819567529	PFKP	-0.422252261677399
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/455	31/9376	0.664728819567529	DPYD	-0.422252261677399
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/455	31/9376	0.664728819567529	GLUL	-0.422252261677399
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/455	31/9376	0.664728819567529	SEC11C	-0.422252261677399
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/455	86/9376	0.718834653718375	EGFR/BRAF/EREG	-0.591544918710319
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/455	60/9376	0.686886446886447	IGF1/BRAF	-0.549474216664388
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/455	32/9376	0.643956043956044	GABARAP	-0.455613683693286
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/455	33/9376	0.624442224442224	BCAT1	-0.488062140651254
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/455	115/9376	0.716751075011945	MAOB/DUSP1/GNG10/BRAF	-0.690196599389753
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/455	35/9376	0.588759811616954	PFKP	-0.550449463030555
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/455	142/9376	0.72558427488005	UBE2D1/BIRC3/PRKN/UBE2S/UBE2E2	-0.744119693462393
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/455	65/9376	0.634049027895182	CREB5/CREB3L1	-0.668599406875937
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/455	195/9376	0.739723865877712	ACTB/FCGR3B/C5AR1/PPIF/CASP1/NFKB1/HDAC9	-0.829451938311591
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/455	37/9376	0.556934956934957	GLUL	-0.609821493995198
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/455	67/9376	0.615122191241594	LDHA/PFKP	-0.713991964902975
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/455	38/9376	0.542278773857721	HEXB	-0.638484682768718
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/455	38/9376	0.542278773857721	IGF1	-0.638484682768718
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/455	69/9376	0.597292562509954	FYN/MAP2K3	-0.758217677872042
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/455	149/9376	0.691496423040047	MT-ND3/NDUFA4/GNG10/MT-ND4/MT-ND2	-0.857250297671831
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/455	98/9376	0.630814083875308	CREB5/CREB3L1/ATP2B1	-0.829689407570058
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/455	41/9376	0.502599839185205	MAOB	-0.720817389645318
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/455	154/9376	0.669045240473812	NME2/GPHN/GCH1/BCAT1/RFK	-0.935192466031703
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/455	73/9376	0.564564202920367	MGST1/MAOB	-0.843448588637751
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/455	42/9376	0.490633176347462	MAOB	-0.747146847988887
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/455	43/9376	0.479223102478916	PLPP1	-0.772965075277904
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/455	133/9376	0.61974717012311	CREB5/MAOB/CREB3L1/GNG10	-0.997416080276618
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/455	45/9376	0.457924297924298	ABCA9	-0.823164570727566
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/455	47/9376	0.438438157587094	LDHA	-0.871592610365776
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/455	191/9376	0.647327541568379	CREB5/MAOB/CREB3L1/GNG10/BRAF/HDAC9	-1.11207279191782
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/455	110/9376	0.561998001998002	HSP90AA1/IGF1/BRAF	-1.04354421073718
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/455	48/9376	0.429304029304029	BCAT1	-0.895191032676843
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/455	169/9376	0.60966252682229	GABARAP/SQSTM1/BCL2/DDIT4/ERN1	-1.15640269199521
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/455	52/9376	0.396280642434489	IGF1	-0.985871262650315
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/455	52/9376	0.396280642434489	APOE	-0.985871262650315
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/455	117/9376	0.528374189912651	ACTB/BAZ1A/SMARCB1	-1.15929248297339
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/455	59/9376	0.349264295027007	PTGER3	-1.13234081446217
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/455	158/9376	0.521685909027681	CDKN1C/GADD45B/CDKN2A/TGFB1	-1.3693294029618
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/455	97/9376	0.424878214568936	GNG10/PER2	-1.28581848662701
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/455	62/9376	0.332364409783765	ADAM17	-1.19110973651823
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/455	63/9376	0.327088784231641	CAMKMT	-1.21022970115156
NA	NA	hsa04081	Hormone signaling	6/455	219/9376	0.564564202920367	RAMP1/IGF1/GNG10/PTHLH/HEPH/PRL	-1.47249607759368
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/455	65/9376	0.317024513947591	TRPC4	-1.24780924138289
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/455	102/9376	0.404050851109675	ATP2B1/KCNMA1	-1.36665945663281
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/455	66/9376	0.312221112221112	CYP7B1	-1.26628229483759
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/455	67/9376	0.307561095620797	BRAF	-1.28455266233162
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/455	138/9376	0.447969421882465	SORBS1/FOXO1/BRAF	-1.47536088759704
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/455	70/9376	0.294379905808477	MGST1	-1.33820609198367
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	11/455	370/9376	0.612628452628453	F2R/TAC3/C5AR1/HRH1/GRIK2/EDN1/ADM/PRL/RXFP1/PTGER3/APLN	-1.71690859984875
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/455	76/9376	0.271139386928861	ACTB	-1.44076905044341
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/455	116/9376	0.355286093217128	PFKP/SUCLG2	-1.57788412348665
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/455	78/9376	0.264187094956326	SYNJ2	-1.47368443891216
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/455	78/9376	0.264187094956326	PFKP	-1.47368443891216
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/455	79/9376	0.260842954513841	MGST1	-1.48992160523807
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/455	79/9376	0.260842954513841	ATP6V0C	-1.48992160523807
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/455	83/9376	0.248272209717993	UBE2D1	-1.55348208845852
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/455	86/9376	0.239611551239458	PDE1C	-1.59978435841727
NA	NA	hsa04082	Neuroactive ligand signaling	4/455	199/9376	0.414202882544591	TAC3/GNG10/HRH1/GRIK2	-1.88628785928973
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/455	98/9376	0.210271361291769	SYNJ2	-1.77479545609112
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/455	103/9376	0.200064013656247	NXT1	-1.84352182693781
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/455	108/9376	0.190801790801791	NXT1	-1.91010985379539
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/455	243/9376	0.339203183647628	HSPA1A/HSPA6/HSPA1B/DDX5	-2.35694211550763
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/455	138/9376	0.149323140627488	IGF1	-2.27352508366823
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/455	183/9376	0.112604335555155	NXT1	-2.7377814980515
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/455	449/9376	0.0917888347732446	RGS2/PDE1C	-4.45391379049155