ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005178 integrin binding 35/769 161/18639 0.217391304347826 5.26912421552553 3.6595431746524e-16 3.53511870671422e-13 GO:0005201 extracellular matrix structural constituent 35/769 168/18639 0.208333333333333 5.04957737321196 1.47633172667297e-15 7.13068223983047e-13 GO:0001968 fibronectin binding 12/769 30/18639 0.4 9.69518855656697 9.74303039021814e-10 3.13725578565024e-07 GO:0005518 collagen binding 17/769 72/18639 0.236111111111111 5.72285435630689 3.93437769577771e-09 9.50152213530318e-07 GO:0005539 glycosaminoglycan binding 31/769 242/18639 0.128099173553719 3.10486410385926 2.21097149471997e-08 4.27159692779899e-06 GO:0002020 protease binding 22/769 136/18639 0.161764705882353 3.92084831331752 3.87441143631594e-08 6.23780241246867e-06 GO:0005125 cytokine activity 28/769 234/18639 0.11965811965812 2.90027008102431 4.41840155665168e-07 6.09739414817931e-05 GO:0008201 heparin binding 23/769 172/18639 0.133720930232558 3.24112408141047 6.6991161740679e-07 6.83324120070821e-05 GO:0042056 chemoattractant activity 11/769 42/18639 0.261904761904762 6.34804012632361 7.28081210083959e-07 6.83324120070821e-05 GO:0061134 peptidase regulator activity 27/769 226/18639 0.119469026548673 2.89568684764721 7.30034523065483e-07 6.83324120070821e-05 GO:0019838 growth factor binding 20/769 136/18639 0.147058823529412 3.56440755756139 7.78112352047519e-07 6.83324120070821e-05 GO:0042605 peptide antigen binding 11/769 45/18639 0.244444444444444 5.92483745123537 1.54183875529319e-06 0.000124118019801102 GO:0050840 extracellular matrix binding 13/769 67/18639 0.194029850746269 4.70288997146905 2.92794230044212e-06 0.000215055729013232 GO:0003779 actin binding 40/769 443/18639 0.090293453724605 2.18853014820925 3.11674969584394e-06 0.000215055729013232 GO:0005520 insulin-like growth factor binding 7/769 19/18639 0.368421052631579 8.9297789336801 6.45839825491736e-06 0.000415920847616678 GO:0061135 endopeptidase regulator activity 22/769 184/18639 0.119565217391304 2.89801831853904 7.54820200544334e-06 0.000455722696078642 GO:0023026 MHC class II protein complex binding 8/769 27/18639 0.296296296296296 7.18162115301257 8.93814451402983e-06 0.000507896917679578 GO:0008191 metalloendopeptidase inhibitor activity 6/769 14/18639 0.428571428571429 10.3877020248932 1.09299186531009e-05 0.000557027607904317 GO:0004866 endopeptidase inhibitor activity 20/769 161/18639 0.124223602484472 3.01092812315744 1.09560295550539e-05 0.000557027607904317 GO:0008083 growth factor activity 20/769 162/18639 0.123456790123457 2.99234214708857 1.20248332990664e-05 0.000573802746400908 GO:0140313 molecular sequestering activity 11/769 55/18639 0.2 4.84759427828349 1.24739727478458e-05 0.000573802746400908 GO:0023023 MHC protein complex binding 9/769 37/18639 0.243243243243243 5.89572277088532 1.45266806146092e-05 0.000637853339714205 GO:0048306 calcium-dependent protein binding 13/769 80/18639 0.1625 3.93867035110533 2.21939645522668e-05 0.000907071393418951 GO:0030414 peptidase inhibitor activity 20/769 169/18639 0.118343195266272 2.86839898123283 2.25359352402224e-05 0.000907071393418951 GO:0050786 RAGE receptor binding 5/769 11/18639 0.454545454545455 11.0172597233716 4.4296778642415e-05 0.00171162752674292 GO:0042277 peptide binding 24/769 249/18639 0.0963855421686747 2.3361900136306 0.000105965973863749 0.00376459346848 GO:0043394 proteoglycan binding 8/769 37/18639 0.216216216216216 5.24064246300917 0.000107820940026122 0.00376459346848 GO:0001664 G protein-coupled receptor binding 27/769 297/18639 0.0909090909090909 2.20345194467431 0.00010911865126029 0.00376459346848 GO:0031994 insulin-like growth factor I binding 5/769 13/18639 0.384615384615385 9.3222966890067 0.000115162123644724 0.00383609004968286 GO:0005161 platelet-derived growth factor receptor binding 5/769 14/18639 0.357142857142857 8.65641835407765 0.000173068904195625 0.00557281871509912 GO:1901681 sulfur compound binding 25/769 275/18639 0.0909090909090909 2.20345194467431 0.000193587582675721 0.00603243886660471 GO:0070851 growth factor receptor binding 16/769 139/18639 0.115107913669065 2.78998231843654 0.000200770883562913 0.00606077104755544 GO:0008307 structural constituent of muscle 8/769 42/18639 0.19047619047619 4.61675645550808 0.000274727771652157 0.0080420311338177 GO:0140311 protein sequestering activity 7/769 33/18639 0.212121212121212 5.14138787090673 0.000330584406040098 0.00939248635984515 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 5/769 16/18639 0.3125 7.57436605981795 0.000352478511331725 0.0097284069127556 GO:0005126 cytokine receptor binding 24/769 275/18639 0.0872727272727273 2.11531386688734 0.000469207055300437 0.0125903893172284 GO:0044325 transmembrane transporter binding 15/769 136/18639 0.110294117647059 2.67330566817104 0.000498386873644617 0.0130119383767757 GO:0005507 copper ion binding 9/769 63/18639 0.142857142857143 3.46256734163106 0.0010613564870288 0.0263535692888865 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 5/769 20/18639 0.25 6.05949284785436 0.00109062771368879 0.0263535692888865 GO:0035497 cAMP response element binding 4/769 12/18639 0.333333333333333 8.07932379713914 0.00109124510512988 0.0263535692888865 GO:0004857 enzyme inhibitor activity 31/769 416/18639 0.0745192307692308 1.80619498349505 0.00114896794231438 0.0270708056652606 GO:0017147 Wnt-protein binding 6/769 31/18639 0.193548387096774 4.6912202693066 0.00147082200792449 0.0338289061822633 GO:0045296 cadherin binding 26/769 334/18639 0.0778443113772455 1.88678819214627 0.00151732754679157 0.0340869397721083 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/769 22/18639 0.227272727272727 5.50862986168578 0.00172997258396313 0.037980761729736 GO:0001618 virus receptor activity 10/769 81/18639 0.123456790123457 2.99234214708857 0.00179368141534713 0.0383911784509204 GO:0004867 serine-type endopeptidase inhibitor activity 11/769 95/18639 0.115789473684211 2.80650195058518 0.00182815135480573 0.0383911784509204 GO:0140272 exogenous protein binding 10/769 82/18639 0.121951219512195 2.95585016968505 0.0019689902760158 0.040276038643877 GO:0043014 alpha-tubulin binding 7/769 44/18639 0.159090909090909 3.85604090318004 0.00200129384565848 0.040276038643877 GO:0001540 amyloid-beta binding 10/769 83/18639 0.120481927710843 2.92023751703824 0.0021578582380955 0.0425406338367398 GO:0097110 scaffold protein binding 9/769 70/18639 0.128571428571429 3.11631060746795 0.00225850962696319 0.0433199928763344 GO:0008009 chemokine activity 7/769 45/18639 0.155555555555556 3.7703511053316 0.00228708036924747 0.0433199928763344 GO:0019955 cytokine binding 14/769 144/18639 0.0972222222222222 2.35646944083225 0.00255283957775535 0.047423904463686 GO:0051371 muscle alpha-actinin binding 4/769 15/18639 0.266666666666667 6.46345903771131 0.00272587181343473 0.0496828711656216 GO:0016209 antioxidant activity 10/769 86/18639 0.116279069767442 2.81836876644389 0.002813383782712 0.0503283098907369 GO:0004709 MAP kinase kinase kinase activity 5/769 25/18639 0.2 4.84759427828349 0.00315080963677074 0.0553396747112825 GO:0015026 coreceptor activity 8/769 61/18639 0.131147540983607 3.1787503464154 0.00344644636054639 0.0594511997194252 GO:0044183 protein folding chaperone 9/769 75/18639 0.12 2.90855656697009 0.00363585550572247 0.0606271264781985 GO:0001222 transcription corepressor binding 7/769 49/18639 0.142857142857143 3.46256734163106 0.0037557556977371 0.0606271264781985 GO:0035254 glutamate receptor binding 7/769 49/18639 0.142857142857143 3.46256734163106 0.0037557556977371 0.0606271264781985 GO:0042805 actinin binding 6/769 37/18639 0.162162162162162 3.93048184725688 0.00376566002970177 0.0606271264781985 GO:0051015 actin filament binding 17/769 209/18639 0.0813397129186603 1.97150963470859 0.00607463812074515 0.0950453969268363 GO:0043236 laminin binding 5/769 29/18639 0.172413793103448 4.17896058472714 0.0061478089115252 0.0950453969268363 GO:0030246 carbohydrate binding 21/769 280/18639 0.075 1.81784785435631 0.00627622453836449 0.0950453969268363 GO:0032934 sterol binding 8/769 68/18639 0.117647058823529 2.85152604604911 0.00672882411419503 0.0950453969268363 GO:0030957 Tat protein binding 3/769 10/18639 0.3 7.27139141742523 0.0067528036631587 0.0950453969268363 GO:0031720 haptoglobin binding 3/769 10/18639 0.3 7.27139141742523 0.0067528036631587 0.0950453969268363 GO:0032395 MHC class II receptor activity 3/769 10/18639 0.3 7.27139141742523 0.0067528036631587 0.0950453969268363 GO:0035256 G protein-coupled glutamate receptor binding 3/769 10/18639 0.3 7.27139141742523 0.0067528036631587 0.0950453969268363 GO:0016918 retinal binding 4/769 19/18639 0.210526315789474 5.10273081924577 0.00678895692334545 0.0950453969268363 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 20/769 268/18639 0.0746268656716418 1.8088038351804 0.0079388048730481 0.109555507248064 GO:0016504 peptidase activator activity 7/769 57/18639 0.12280701754386 2.97659297789337 0.00871093597336919 0.114434444502601 GO:0030020 extracellular matrix structural constituent conferring tensile strength 6/769 44/18639 0.136363636363636 3.30517791701147 0.00896616986942929 0.114434444502601 GO:0015173 aromatic amino acid transmembrane transporter activity 3/769 11/18639 0.272727272727273 6.61035583402293 0.00900312399813421 0.114434444502601 GO:0042608 T cell receptor binding 3/769 11/18639 0.272727272727273 6.61035583402293 0.00900312399813421 0.114434444502601 GO:0048407 platelet-derived growth factor binding 3/769 11/18639 0.272727272727273 6.61035583402293 0.00900312399813421 0.114434444502601 GO:0050998 nitric-oxide synthase binding 3/769 11/18639 0.272727272727273 6.61035583402293 0.00900312399813421 0.114434444502601 GO:0042379 chemokine receptor binding 8/769 72/18639 0.111111111111111 2.69310793237971 0.00944274640679045 0.118463545830644 GO:0051082 unfolded protein binding 11/769 121/18639 0.0909090909090909 2.20345194467431 0.011461574006967 0.140558034821813 GO:0001217 DNA-binding transcription repressor activity 20/769 278/18639 0.0719424460431655 1.74373894902284 0.0115986455388409 0.140558034821813 GO:0015269 calcium-activated potassium channel activity 3/769 12/18639 0.25 6.05949284785436 0.011640416962469 0.140558034821813 GO:0019825 oxygen binding 5/769 34/18639 0.147058823529412 3.56440755756139 0.0121658313733286 0.145088803785623 GO:0098631 cell adhesion mediator activity 8/769 76/18639 0.105263157894737 2.55136540962289 0.0128979282759548 0.151943886763077 GO:0003823 antigen binding 14/769 174/18639 0.0804597701149425 1.950181606206 0.0131925926963142 0.152929662946081 GO:0043178 alcohol binding 9/769 92/18639 0.0978260869565217 2.37110589698649 0.0135956136371961 0.152929662946081 GO:0005212 structural constituent of eye lens 4/769 23/18639 0.173913043478261 4.21529937242042 0.0136148561214938 0.152929662946081 GO:0099186 structural constituent of postsynapse 4/769 23/18639 0.173913043478261 4.21529937242042 0.0136148561214938 0.152929662946081 GO:0003735 structural constituent of ribosome 14/769 175/18639 0.08 1.93903771131339 0.0138157596871606 0.153402573078129 GO:0004252 serine-type endopeptidase activity 14/769 176/18639 0.0795454545454545 1.92802045159002 0.0144614075552033 0.156740099642751 GO:0005172 vascular endothelial growth factor receptor binding 3/769 13/18639 0.230769230769231 5.59337801340402 0.0146750241221394 0.156740099642751 GO:0035325 Toll-like receptor binding 3/769 13/18639 0.230769230769231 5.59337801340402 0.0146750241221394 0.156740099642751 GO:0008236 serine-type peptidase activity 15/769 194/18639 0.077319587628866 1.87406995294465 0.0147653717054766 0.156740099642751 GO:0019199 transmembrane receptor protein kinase activity 8/769 78/18639 0.102564102564103 2.48594578373512 0.0149361932452597 0.156830029075227 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/769 24/18639 0.166666666666667 4.03966189856957 0.0158162261312482 0.162536962157296 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/769 24/18639 0.166666666666667 4.03966189856957 0.0158162261312482 0.162536962157296 GO:0048020 CCR chemokine receptor binding 6/769 50/18639 0.12 2.90855656697009 0.0164082200461213 0.166845690153191 GO:0005200 structural constituent of cytoskeleton 10/769 112/18639 0.0892857142857143 2.16410458851941 0.017410816560028 0.173247682474176 GO:0017171 serine hydrolase activity 15/769 198/18639 0.0757575757575758 1.83620995389526 0.0174716817497178 0.173247682474176 GO:0005344 oxygen carrier activity 3/769 14/18639 0.214285714285714 5.19385101244659 0.0181138881261819 0.173247682474176 GO:0008195 phosphatidate phosphatase activity 3/769 14/18639 0.214285714285714 5.19385101244659 0.0181138881261819 0.173247682474176 GO:0032036 myosin heavy chain binding 3/769 14/18639 0.214285714285714 5.19385101244659 0.0181138881261819 0.173247682474176 GO:0044548 S100 protein binding 3/769 14/18639 0.214285714285714 5.19385101244659 0.0181138881261819 0.173247682474176 GO:0005501 retinoid binding 5/769 38/18639 0.131578947368421 3.18920676202861 0.0191858346569363 0.179937051248549 GO:0019840 isoprenoid binding 5/769 38/18639 0.131578947368421 3.18920676202861 0.0191858346569363 0.179937051248549 GO:0031072 heat shock protein binding 11/769 131/18639 0.083969465648855 2.03524950614956 0.0197574828599523 0.18351661964148 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/769 26/18639 0.153846153846154 3.72891867560268 0.0208574509101903 0.19007827904947 GO:0050750 low-density lipoprotein particle receptor binding 4/769 26/18639 0.153846153846154 3.72891867560268 0.0208574509101903 0.19007827904947 GO:0050700 CARD domain binding 3/769 15/18639 0.2 4.84759427828349 0.0219608922043687 0.198263755788974 GO:0051087 protein-folding chaperone binding 11/769 134/18639 0.082089552238806 1.98968421869845 0.022946561059897 0.205244240591301 GO:0140662 ATP-dependent protein folding chaperone 5/769 40/18639 0.125 3.02974642392718 0.0235225872584796 0.208466232033865 GO:0008142 oxysterol binding 3/769 16/18639 0.1875 4.54461963589077 0.0262171743482687 0.226932888862959 GO:0019841 retinol binding 3/769 16/18639 0.1875 4.54461963589077 0.0262171743482687 0.226932888862959 GO:0051019 mitogen-activated protein kinase binding 4/769 28/18639 0.142857142857143 3.46256734163106 0.0267808999279269 0.226932888862959 GO:0051393 alpha-actinin binding 4/769 28/18639 0.142857142857143 3.46256734163106 0.0267808999279269 0.226932888862959 GO:0097718 disordered domain specific binding 4/769 28/18639 0.142857142857143 3.46256734163106 0.0267808999279269 0.226932888862959 GO:0048487 beta-tubulin binding 5/769 42/18639 0.119047619047619 2.88547278469255 0.0284457045538238 0.229472689267027 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 29/769 484/18639 0.0599173553719008 1.45227514535352 0.029029864344468 0.229472689267027 GO:0030295 protein kinase activator activity 11/769 139/18639 0.079136690647482 1.91811284392512 0.0290732952133788 0.229472689267027 GO:0004601 peroxidase activity 6/769 57/18639 0.105263157894737 2.55136540962289 0.0294746682240478 0.229472689267027 GO:0003785 actin monomer binding 4/769 29/18639 0.137931034482759 3.34316846778171 0.0300821944905512 0.229472689267027 GO:0051861 glycolipid binding 4/769 29/18639 0.137931034482759 3.34316846778171 0.0300821944905512 0.229472689267027 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 8/769 89/18639 0.0898876404494382 2.1786940576555 0.0304698873697312 0.229472689267027 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 8/769 89/18639 0.0898876404494382 2.1786940576555 0.0304698873697312 0.229472689267027 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0005092 GDP-dissociation inhibitor activity 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0008484 sulfuric ester hydrolase activity 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0019198 transmembrane receptor protein phosphatase activity 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0045236 CXCR chemokine receptor binding 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0048038 quinone binding 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0070492 oligosaccharide binding 3/769 17/18639 0.176470588235294 4.27728906907366 0.0308814178102624 0.229472689267027 GO:0048156 tau protein binding 5/769 43/18639 0.116279069767442 2.81836876644389 0.031133769094063 0.229581839273778 GO:0140793 histone H2AXY142 phosphatase activity 8/769 90/18639 0.0888888888888889 2.15448634590377 0.0322837105544667 0.236258063603142 GO:0051721 protein phosphatase 2A binding 4/769 30/18639 0.133333333333333 3.23172951885566 0.0336130431712251 0.239281330237708 GO:0098918 structural constituent of synapse 4/769 30/18639 0.133333333333333 3.23172951885566 0.0336130431712251 0.239281330237708 GO:0030547 signaling receptor inhibitor activity 5/769 44/18639 0.113636363636364 2.75431493084289 0.0339757689946571 0.239281330237708 GO:0001216 DNA-binding transcription activator activity 29/769 491/18639 0.0590631364562118 1.43157061171305 0.0340819700858168 0.239281330237708 GO:0004879 nuclear receptor activity 6/769 59/18639 0.101694915254237 2.46487844658482 0.0341830471768155 0.239281330237708 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/769 59/18639 0.101694915254237 2.46487844658482 0.0341830471768155 0.239281330237708 GO:0005496 steroid binding 9/769 108/18639 0.0833333333333333 2.01983094928479 0.0345098923871356 0.239831338460237 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/769 18/18639 0.166666666666667 4.03966189856957 0.0359501194584031 0.244558202788277 GO:0004706 JUN kinase kinase kinase activity 3/769 18/18639 0.166666666666667 4.03966189856957 0.0359501194584031 0.244558202788277 GO:0098641 cadherin binding involved in cell-cell adhesion 3/769 18/18639 0.166666666666667 4.03966189856957 0.0359501194584031 0.244558202788277 GO:0019903 protein phosphatase binding 11/769 144/18639 0.0763888888888889 1.85151170351105 0.0362920960901773 0.244558202788277 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/769 60/18639 0.1 2.42379713914174 0.0367090470023812 0.244558202788277 GO:0098531 ligand-modulated transcription factor activity 6/769 60/18639 0.1 2.42379713914174 0.0367090470023812 0.244558202788277 GO:0070325 lipoprotein particle receptor binding 4/769 31/18639 0.129032258064516 3.12748017953773 0.0373749304215964 0.247288923200426 GO:0042562 hormone binding 8/769 94/18639 0.0851063829787234 2.06280607586531 0.0402721502636542 0.264645558875442 GO:0120015 sterol transfer activity 4/769 32/18639 0.125 3.02974642392718 0.0413686504430535 0.268521013160937 GO:0042577 lipid phosphatase activity 3/769 19/18639 0.157894736842105 3.82704811443433 0.0414178374337263 0.268521013160937 GO:0019209 kinase activator activity 11/769 148/18639 0.0743243243243243 1.8014708466594 0.0429080866865174 0.276328078261172 GO:0005504 fatty acid binding 5/769 47/18639 0.106382978723404 2.57850759483164 0.0434420736304046 0.277914192893847 GO:0033293 monocarboxylic acid binding 7/769 79/18639 0.0886075949367089 2.14766835113825 0.0442920604315575 0.281487699847925 GO:0019956 chemokine binding 4/769 33/18639 0.121212121212121 2.93793592623242 0.0455943320718266 0.282334133214003 GO:0030296 protein tyrosine kinase activator activity 4/769 33/18639 0.121212121212121 2.93793592623242 0.0455943320718266 0.282334133214003 GO:0071889 14-3-3 protein binding 4/769 33/18639 0.121212121212121 2.93793592623242 0.0455943320718266 0.282334133214003 GO:0140416 transcription regulator inhibitor activity 4/769 33/18639 0.121212121212121 2.93793592623242 0.0455943320718266 0.282334133214003 GO:0140693 molecular condensate scaffold activity 5/769 48/18639 0.104166666666667 2.52478868660598 0.0469149986620419 0.285437420052699 GO:0016004 phospholipase activator activity 3/769 20/18639 0.15 3.63569570871261 0.0472774194704264 0.285437420052699 GO:0030742 GTP-dependent protein binding 3/769 20/18639 0.15 3.63569570871261 0.0472774194704264 0.285437420052699 GO:0043024 ribosomal small subunit binding 3/769 20/18639 0.15 3.63569570871261 0.0472774194704264 0.285437420052699 GO:0004175 endopeptidase activity 24/769 405/18639 0.0592592592592593 1.43632423060251 0.0487941769339836 0.292765061603902 GO:0004725 protein tyrosine phosphatase activity 8/769 98/18639 0.0816326530612245 1.97860990950346 0.0494783791301638 0.295037742220606 GO:0009055 electron transfer activity 9/769 116/18639 0.0775862068965517 1.88053226312721 0.050620899190985 0.299998703180929 GO:0120013 lipid transfer activity 6/769 65/18639 0.0923076923076923 2.23735120536161 0.0511086874341986 0.301042634520951 GO:1990782 protein tyrosine kinase binding 9/769 117/18639 0.0769230769230769 1.86445933780134 0.0529311396069726 0.309887762789912 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/769 21/18639 0.142857142857143 3.46256734163106 0.0535202131579502 0.311448951268554 GO:0022853 active monoatomic ion transmembrane transporter activity 9/769 118/18639 0.076271186440678 1.84865883493862 0.0553091871167758 0.319932184160512 GO:0005021 vascular endothelial growth factor receptor activity 5/769 51/18639 0.0980392156862745 2.37627170504092 0.0582949481664725 0.327740258885407 GO:0030544 Hsp70 protein binding 5/769 51/18639 0.0980392156862745 2.37627170504092 0.0582949481664725 0.327740258885407 GO:0140375 immune receptor activity 11/769 156/18639 0.0705128205128205 1.7090877263179 0.0585310085997046 0.327740258885407 GO:0004869 cysteine-type endopeptidase inhibitor activity 4/769 36/18639 0.111111111111111 2.69310793237971 0.0596550255451085 0.327740258885407 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/769 68/18639 0.0882352941176471 2.13864453453683 0.0611948298375898 0.327740258885407 GO:1990841 promoter-specific chromatin binding 6/769 68/18639 0.0882352941176471 2.13864453453683 0.0611948298375898 0.327740258885407 GO:0004090 carbonyl reductase (NADPH) activity 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0005381 iron ion transmembrane transporter activity 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0019911 structural constituent of myelin sheath 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0031996 thioesterase binding 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0043208 glycosphingolipid binding 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0070513 death domain binding 2/769 10/18639 0.2 4.84759427828349 0.0614088890872244 0.327740258885407 GO:0004713 protein tyrosine kinase activity 10/769 140/18639 0.0714285714285714 1.73128367081553 0.0645014773331498 0.342353995075949 GO:0005319 lipid transporter activity 12/769 178/18639 0.0674157303370786 1.63402054324162 0.0653390523894843 0.344904506055967 GO:0004602 glutathione peroxidase activity 3/769 23/18639 0.130434782608696 3.16147452931532 0.0671144698311391 0.346698277309521 GO:0005158 insulin receptor binding 3/769 23/18639 0.130434782608696 3.16147452931532 0.0671144698311391 0.346698277309521 GO:0017134 fibroblast growth factor binding 3/769 23/18639 0.130434782608696 3.16147452931532 0.0671144698311391 0.346698277309521 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/769 23/18639 0.130434782608696 3.16147452931532 0.0671144698311391 0.346698277309521 GO:0015485 cholesterol binding 5/769 54/18639 0.0925925925925926 2.24425661031643 0.0711146036357296 0.358227196771828 GO:0004197 cysteine-type endopeptidase activity 7/769 88/18639 0.0795454545454545 1.92802045159002 0.0711523971208459 0.358227196771828 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/769 88/18639 0.0795454545454545 1.92802045159002 0.0711523971208459 0.358227196771828 GO:0008013 beta-catenin binding 8/769 106/18639 0.0754716981132075 1.82928085972962 0.071716587837802 0.358227196771828 GO:0008199 ferric iron binding 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:0035252 UDP-xylosyltransferase activity 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:0042285 xylosyltransferase activity 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:0047676 arachidonate-CoA ligase activity 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:0097493 structural molecule activity conferring elasticity 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:1990948 ubiquitin ligase inhibitor activity 2/769 11/18639 0.181818181818182 4.40690388934862 0.0730546146625777 0.358227196771828 GO:0005540 hyaluronic acid binding 3/769 24/18639 0.125 3.02974642392718 0.0744427903596949 0.359558677437326 GO:0050431 transforming growth factor beta binding 3/769 24/18639 0.125 3.02974642392718 0.0744427903596949 0.359558677437326 GO:0060229 lipase activator activity 3/769 24/18639 0.125 3.02974642392718 0.0744427903596949 0.359558677437326 GO:0044389 ubiquitin-like protein ligase binding 19/769 322/18639 0.0590062111801242 1.43019085849979 0.0756250300388911 0.362033541239652 GO:0098632 cell-cell adhesion mediator activity 5/769 55/18639 0.0909090909090909 2.20345194467431 0.0757047363668838 0.362033541239652 GO:0031625 ubiquitin protein ligase binding 18/769 302/18639 0.0596026490066225 1.44464730147521 0.0762623503155479 0.362903598053297 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/769 40/18639 0.1 2.42379713914174 0.0815530438001673 0.386177648583145 GO:0001848 complement binding 3/769 25/18639 0.12 2.90855656697009 0.0821083499883928 0.386910566286768 GO:0004126 cytidine deaminase activity 2/769 12/18639 0.166666666666667 4.03966189856957 0.0853374542025994 0.396326830575534 GO:0017166 vinculin binding 2/769 12/18639 0.166666666666667 4.03966189856957 0.0853374542025994 0.396326830575534 GO:0097371 MDM2/MDM4 family protein binding 2/769 12/18639 0.166666666666667 4.03966189856957 0.0853374542025994 0.396326830575534 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/769 41/18639 0.0975609756097561 2.36468013574804 0.0875685672268233 0.404139674733899 GO:0033218 amide binding 15/769 247/18639 0.0607287449392713 1.47194158247474 0.0878564510291085 0.404139674733899 GO:0005227 calcium-activated cation channel activity 3/769 26/18639 0.115384615384615 2.79668900670201 0.0900975976942453 0.410018391414138 GO:0030247 polysaccharide binding 3/769 26/18639 0.115384615384615 2.79668900670201 0.0900975976942453 0.410018391414138 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/769 58/18639 0.0862068965517241 2.08948029236357 0.0904077819577758 0.410018391414138 GO:0035198 miRNA binding 4/769 42/18639 0.0952380952380952 2.30837822775404 0.09379202645556 0.423378960542388 GO:0019902 phosphatase binding 12/769 190/18639 0.0631578947368421 1.53081924577373 0.0950323611875607 0.426982608870622 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/769 13/18639 0.153846153846154 3.72891867560268 0.0981851687626832 0.430094790119276 GO:0005035 death receptor activity 2/769 13/18639 0.153846153846154 3.72891867560268 0.0981851687626832 0.430094790119276 GO:0017154 semaphorin receptor activity 2/769 13/18639 0.153846153846154 3.72891867560268 0.0981851687626832 0.430094790119276 GO:0039706 co-receptor binding 2/769 13/18639 0.153846153846154 3.72891867560268 0.0981851687626832 0.430094790119276 GO:0089720 caspase binding 2/769 13/18639 0.153846153846154 3.72891867560268 0.0981851687626832 0.430094790119276 GO:0005104 fibroblast growth factor receptor binding 3/769 27/18639 0.111111111111111 2.69310793237971 0.0983964271390891 0.430094790119276 GO:0001221 transcription coregulator binding 8/769 115/18639 0.0695652173913043 1.68611974896817 0.102974868427661 0.44607050628305 GO:0017124 SH3 domain binding 8/769 115/18639 0.0695652173913043 1.68611974896817 0.102974868427661 0.44607050628305 GO:0003954 NADH dehydrogenase activity 4/769 44/18639 0.0909090909090909 2.20345194467431 0.106842788929614 0.459442670207463 GO:0019887 protein kinase regulator activity 15/769 255/18639 0.0588235294117647 1.42576302302455 0.107274390940724 0.459442670207463 GO:0046332 SMAD binding 6/769 79/18639 0.0759493670886076 1.84085858668993 0.107488657833216 0.459442670207463 GO:0004065 arylsulfatase activity 2/769 14/18639 0.142857142857143 3.46256734163106 0.1115303822021 0.474618278445941 GO:0042578 phosphoric ester hydrolase activity 20/769 363/18639 0.0550964187327824 1.33542542101473 0.116572214815647 0.493898068034714 GO:0001965 G-protein alpha-subunit binding 3/769 30/18639 0.1 2.42379713914174 0.125003330171435 0.5107584532196 GO:0022839 monoatomic ion-gated channel activity 3/769 30/18639 0.1 2.42379713914174 0.125003330171435 0.5107584532196 GO:0004467 long-chain fatty acid-CoA ligase activity 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0008242 omega peptidase activity 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0031005 filamin binding 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0061578 K63-linked deubiquitinase activity 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0140776 protein-containing complex destabilizing activity 2/769 15/18639 0.133333333333333 3.23172951885566 0.125310303740213 0.5107584532196 GO:0019843 rRNA binding 5/769 65/18639 0.0769230769230769 1.86445933780134 0.129887135755078 0.527188962770611 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 19/769 349/18639 0.0544412607449857 1.31954572044966 0.133906112508949 0.538683636181391 GO:0005164 tumor necrosis factor receptor binding 3/769 31/18639 0.0967741935483871 2.3456101346533 0.13439208728749 0.538683636181391 GO:0016878 acid-thiol ligase activity 3/769 31/18639 0.0967741935483871 2.3456101346533 0.13439208728749 0.538683636181391 GO:0003714 transcription corepressor activity 12/769 204/18639 0.0588235294117647 1.42576302302455 0.138549665876715 0.541062671763588 GO:0004708 MAP kinase kinase activity 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0005024 transforming growth factor beta receptor activity 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0005521 lamin binding 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0016722 oxidoreductase activity, acting on metal ions 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0022858 alanine transmembrane transporter activity 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/769 16/18639 0.125 3.02974642392718 0.139466465081919 0.541062671763588 GO:0016763 pentosyltransferase activity 4/769 49/18639 0.0816326530612245 1.97860990950346 0.1427276971354 0.54771135667213 GO:0060590 ATPase regulator activity 4/769 49/18639 0.0816326530612245 1.97860990950346 0.1427276971354 0.54771135667213 GO:0051059 NF-kappaB binding 3/769 32/18639 0.09375 2.27230981794538 0.144015201443811 0.54771135667213 GO:0071813 lipoprotein particle binding 3/769 32/18639 0.09375 2.27230981794538 0.144015201443811 0.54771135667213 GO:0071814 protein-lipid complex binding 3/769 32/18639 0.09375 2.27230981794538 0.144015201443811 0.54771135667213 GO:0015399 primary active transmembrane transporter activity 10/769 166/18639 0.0602409638554217 1.46011875851912 0.149122933488484 0.561171167387633 GO:0008081 phosphoric diester hydrolase activity 6/769 87/18639 0.0689655172413793 1.67158423389086 0.149832676352803 0.561171167387633 GO:0005006 epidermal growth factor receptor activity 4/769 50/18639 0.08 1.93903771131339 0.150413474936711 0.561171167387633 GO:0031406 carboxylic acid binding 11/769 187/18639 0.0588235294117647 1.42576302302455 0.151345625077154 0.561171167387633 GO:0030169 low-density lipoprotein particle binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0036041 long-chain fatty acid binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0038191 neuropilin binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0046965 nuclear retinoid X receptor binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0051787 misfolded protein binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0070402 NADPH binding 2/769 17/18639 0.117647058823529 2.85152604604911 0.153944471384806 0.561171167387633 GO:0042826 histone deacetylase binding 8/769 127/18639 0.062992125984252 1.52680134749086 0.154598317302477 0.56143599441426 GO:0043177 organic acid binding 11/769 189/18639 0.0582010582010582 1.41067558362747 0.159070027140114 0.575511783585579 GO:0016791 phosphatase activity 15/769 273/18639 0.0549450549450549 1.3317566698581 0.159667023710697 0.575516212330348 GO:0008376 acetylgalactosaminyltransferase activity 3/769 34/18639 0.0882352941176471 2.13864453453683 0.163903013176111 0.585399694179722 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 3/769 34/18639 0.0882352941176471 2.13864453453683 0.163903013176111 0.585399694179722 GO:0035591 signaling adaptor activity 8/769 129/18639 0.062015503875969 1.50313000877007 0.164227036358908 0.585399694179722 GO:0003746 translation elongation factor activity 2/769 18/18639 0.111111111111111 2.69310793237971 0.168693765375607 0.59242627725499 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/769 18/18639 0.111111111111111 2.69310793237971 0.168693765375607 0.59242627725499 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/769 18/18639 0.111111111111111 2.69310793237971 0.168693765375607 0.59242627725499 GO:0099602 neurotransmitter receptor regulator activity 2/769 18/18639 0.111111111111111 2.69310793237971 0.168693765375607 0.59242627725499 GO:0004222 metalloendopeptidase activity 7/769 110/18639 0.0636363636363636 1.54241636127202 0.169264650644283 0.59242627725499 GO:0015631 tubulin binding 20/769 385/18639 0.051948051948052 1.25911539695675 0.172954955505023 0.597301742288633 GO:0005154 epidermal growth factor receptor binding 3/769 35/18639 0.0857142857142857 2.07754040497864 0.174137145931206 0.597301742288633 GO:0043015 gamma-tubulin binding 3/769 35/18639 0.0857142857142857 2.07754040497864 0.174137145931206 0.597301742288633 GO:0061631 ubiquitin conjugating enzyme activity 3/769 35/18639 0.0857142857142857 2.07754040497864 0.174137145931206 0.597301742288633 GO:0016860 intramolecular oxidoreductase activity 4/769 53/18639 0.0754716981132075 1.82928085972962 0.174367589363762 0.597301742288633 GO:0038064 collagen receptor activity 4/769 53/18639 0.0754716981132075 1.82928085972962 0.174367589363762 0.597301742288633 GO:0005179 hormone activity 8/769 132/18639 0.0606060606060606 1.46896796311621 0.17917249132834 0.609700042001602 GO:0140463 chromatin-protein adaptor activity 4/769 54/18639 0.0740740740740741 1.79540528825314 0.182627828222005 0.609700042001602 GO:0043539 protein serine/threonine kinase activator activity 5/769 73/18639 0.0684931506849315 1.66013502680941 0.182806358959206 0.609700042001602 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0005229 intracellularly calcium-gated chloride channel activity 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0043395 heparan sulfate proteoglycan binding 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0070003 threonine-type peptidase activity 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0097001 ceramide binding 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0141147 intracellularly calcium-gated channel activity 2/769 19/18639 0.105263157894737 2.55136540962289 0.183667403957004 0.609700042001602 GO:0019003 GDP binding 5/769 75/18639 0.0666666666666667 1.61586475942783 0.197128418419929 0.648106072103169 GO:0035401 histone H3Y41 kinase activity 7/769 115/18639 0.0608695652173913 1.47535478034715 0.197249674118356 0.648106072103169 GO:0140801 histone H2AXY142 kinase activity 7/769 115/18639 0.0608695652173913 1.47535478034715 0.197249674118356 0.648106072103169 GO:0010851 cyclase regulator activity 2/769 20/18639 0.1 2.42379713914174 0.198821846677735 0.648857783414501 GO:0031418 L-ascorbic acid binding 2/769 20/18639 0.1 2.42379713914174 0.198821846677735 0.648857783414501 GO:0140789 histone phosphatase activity 8/769 136/18639 0.0588235294117647 1.42576302302455 0.199981571797772 0.650445112311944 GO:0017022 myosin binding 5/769 76/18639 0.0657894736842105 1.5946033810143 0.204430697642591 0.662684744707192 GO:0019207 kinase regulator activity 15/769 287/18639 0.0522648083623693 1.26679292986502 0.208208213504618 0.67267268978415 GO:0001846 opsonin binding 2/769 21/18639 0.0952380952380952 2.30837822775404 0.214116755469292 0.68679059765987 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/769 21/18639 0.0952380952380952 2.30837822775404 0.214116755469292 0.68679059765987 GO:0140297 DNA-binding transcription factor binding 24/769 488/18639 0.0491803278688525 1.19203137990578 0.214710932187661 0.68679059765987 GO:0061980 regulatory RNA binding 4/769 58/18639 0.0689655172413793 1.67158423389086 0.216855590837591 0.691361388610932 GO:0001786 phosphatidylserine binding 4/769 59/18639 0.0677966101694915 1.64325229772322 0.225673177377126 0.714755047037062 GO:0070888 E-box binding 4/769 59/18639 0.0677966101694915 1.64325229772322 0.225673177377126 0.714755047037062 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/769 40/18639 0.075 1.81784785435631 0.22761403624452 0.715197747447492 GO:0071855 neuropeptide receptor binding 3/769 40/18639 0.075 1.81784785435631 0.22761403624452 0.715197747447492 GO:0008093 cytoskeletal anchor activity 2/769 22/18639 0.0909090909090909 2.20345194467431 0.229514805081493 0.715197747447492 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/769 22/18639 0.0909090909090909 2.20345194467431 0.229514805081493 0.715197747447492 GO:0061133 endopeptidase activator activity 2/769 22/18639 0.0909090909090909 2.20345194467431 0.229514805081493 0.715197747447492 GO:0020037 heme binding 8/769 142/18639 0.0563380281690141 1.36551951500943 0.232894204666318 0.723394860796343 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/769 41/18639 0.0731707317073171 1.77351010181103 0.238670257482759 0.734253085122118 GO:0016877 ligase activity, forming carbon-sulfur bonds 3/769 41/18639 0.0731707317073171 1.77351010181103 0.238670257482759 0.734253085122118 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/769 41/18639 0.0731707317073171 1.77351010181103 0.238670257482759 0.734253085122118 GO:0015101 organic cation transmembrane transporter activity 5/769 81/18639 0.0617283950617284 1.49617107354429 0.242181602429996 0.741856214895785 GO:0031681 G-protein beta-subunit binding 2/769 23/18639 0.0869565217391304 2.10764968621021 0.244981503676765 0.741856214895785 GO:0042171 lysophosphatidic acid acyltransferase activity 2/769 23/18639 0.0869565217391304 2.10764968621021 0.244981503676765 0.741856214895785 GO:0043274 phospholipase binding 2/769 23/18639 0.0869565217391304 2.10764968621021 0.244981503676765 0.741856214895785 GO:0071617 lysophospholipid acyltransferase activity 2/769 23/18639 0.0869565217391304 2.10764968621021 0.244981503676765 0.741856214895785 GO:0019894 kinesin binding 3/769 42/18639 0.0714285714285714 1.73128367081553 0.249814736792543 0.751778927543915 GO:0031492 nucleosomal DNA binding 3/769 42/18639 0.0714285714285714 1.73128367081553 0.249814736792543 0.751778927543915 GO:0015179 L-amino acid transmembrane transporter activity 4/769 62/18639 0.0645161290322581 1.56374008976887 0.25263670202239 0.757910106067169 GO:0030552 cAMP binding 2/769 24/18639 0.0833333333333333 2.01983094928479 0.260485023069226 0.771866663450529 GO:0035035 histone acetyltransferase binding 2/769 24/18639 0.0833333333333333 2.01983094928479 0.260485023069226 0.771866663450529 GO:0050699 WW domain binding 2/769 24/18639 0.0833333333333333 2.01983094928479 0.260485023069226 0.771866663450529 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/769 24/18639 0.0833333333333333 2.01983094928479 0.260485023069226 0.771866663450529 GO:0015085 calcium ion transmembrane transporter activity 8/769 147/18639 0.054421768707483 1.31907327300231 0.261659652388996 0.77297622081887 GO:0001046 core promoter sequence-specific DNA binding 3/769 44/18639 0.0681818181818182 1.65258895850573 0.272316770390517 0.785340168641569 GO:0001223 transcription coactivator binding 3/769 44/18639 0.0681818181818182 1.65258895850573 0.272316770390517 0.785340168641569 GO:0003707 nuclear steroid receptor activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0015645 fatty acid ligase activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0015662 P-type ion transporter activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0042974 nuclear retinoic acid receptor binding 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0120020 cholesterol transfer activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0120515 fatty acid-CoA ligase activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0140358 P-type transmembrane transporter activity 2/769 25/18639 0.08 1.93903771131339 0.275996038119734 0.785340168641569 GO:0050660 flavin adenine dinucleotide binding 5/769 86/18639 0.0581395348837209 1.40918438322194 0.281596220341903 0.785340168641569 GO:0004715 non-membrane spanning protein tyrosine kinase activity 3/769 45/18639 0.0666666666666667 1.61586475942783 0.283649446668574 0.785340168641569 GO:0046906 tetrapyrrole binding 8/769 152/18639 0.0526315789473684 1.27568270481144 0.291415674567816 0.785340168641569 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0008198 ferrous iron binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0019865 immunoglobulin binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0030507 spectrin binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0043548 phosphatidylinositol 3-kinase binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0050681 nuclear androgen receptor binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0070412 R-SMAD binding 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0120014 phospholipid transfer activity 2/769 26/18639 0.0769230769230769 1.86445933780134 0.291487574821858 0.785340168641569 GO:0003924 GTPase activity 16/769 331/18639 0.0483383685800604 1.1716239947513 0.293120647173265 0.785340168641569 GO:0141003 histone H2AX kinase activity 17/769 354/18639 0.0480225988700565 1.16397037755394 0.294441187453867 0.785340168641569 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/769 46/18639 0.0652173913043478 1.58073726465766 0.295020647769746 0.785340168641569 GO:0005262 calcium channel activity 7/769 131/18639 0.0534351145038168 1.29515877664063 0.296712751839156 0.785340168641569 GO:0140996 histone H3 kinase activity 17/769 357/18639 0.0476190476190476 1.15418911387702 0.306323200035166 0.785340168641569 GO:0001671 ATPase activator activity 2/769 27/18639 0.0740740740740741 1.79540528825314 0.306934866636479 0.785340168641569 GO:0015252 proton channel activity 2/769 27/18639 0.0740740740740741 1.79540528825314 0.306934866636479 0.785340168641569 GO:0016405 CoA-ligase activity 2/769 27/18639 0.0740740740740741 1.79540528825314 0.306934866636479 0.785340168641569 GO:0035255 ionotropic glutamate receptor binding 2/769 27/18639 0.0740740740740741 1.79540528825314 0.306934866636479 0.785340168641569 GO:0030145 manganese ion binding 4/769 68/18639 0.0588235294117647 1.42576302302455 0.308234879779716 0.785340168641569 GO:0035173 histone kinase activity 17/769 360/18639 0.0472222222222222 1.14457087126138 0.3183432524255 0.785340168641569 GO:0072341 modified amino acid binding 5/769 91/18639 0.0549450549450549 1.3317566698581 0.322129532234328 0.785340168641569 GO:0046625 sphingolipid binding 2/769 28/18639 0.0714285714285714 1.73128367081553 0.32231521865433 0.785340168641569 GO:0046875 ephrin receptor binding 2/769 28/18639 0.0714285714285714 1.73128367081553 0.32231521865433 0.785340168641569 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/769 28/18639 0.0714285714285714 1.73128367081553 0.32231521865433 0.785340168641569 GO:0016782 transferase activity, transferring sulphur-containing groups 4/769 70/18639 0.0571428571428571 1.38502693665242 0.327066618123421 0.785340168641569 GO:0005004 GPI-linked ephrin receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0005008 hepatocyte growth factor receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0005009 insulin receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0005011 macrophage colony-stimulating factor receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0005020 stem cell factor receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0008288 boss receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0036332 placental growth factor receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0038062 protein tyrosine kinase collagen receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0060175 brain-derived neurotrophic factor receptor activity 3/769 49/18639 0.0612244897959184 1.4839574321276 0.329253296778168 0.785340168641569 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 9/769 181/18639 0.0497237569060773 1.2052029973633 0.331624011605013 0.785340168641569 GO:0004629 phospholipase C activity 2/769 29/18639 0.0689655172413793 1.67158423389086 0.337607879186397 0.785340168641569 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/769 29/18639 0.0689655172413793 1.67158423389086 0.337607879186397 0.785340168641569 GO:0099604 ligand-gated calcium channel activity 2/769 29/18639 0.0689655172413793 1.67158423389086 0.337607879186397 0.785340168641569 GO:0005007 fibroblast growth factor receptor activity 3/769 50/18639 0.06 1.45427828348505 0.340668604555282 0.785340168641569 GO:0005017 platelet-derived growth factor receptor activity 3/769 50/18639 0.06 1.45427828348505 0.340668604555282 0.785340168641569 GO:0005019 platelet-derived growth factor beta-receptor activity 3/769 50/18639 0.06 1.45427828348505 0.340668604555282 0.785340168641569 GO:0032813 tumor necrosis factor receptor superfamily binding 3/769 50/18639 0.06 1.45427828348505 0.340668604555282 0.785340168641569 GO:0000182 rDNA binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0003796 lysozyme activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0004955 prostaglandin receptor activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0005031 tumor necrosis factor receptor activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0005522 profilin binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0008140 cAMP response element binding protein binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0008190 eukaryotic initiation factor 4E binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0008239 dipeptidyl-peptidase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0015187 glycine transmembrane transporter activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0015203 polyamine transmembrane transporter activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0015279 store-operated calcium channel activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0031434 mitogen-activated protein kinase kinase binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0032052 bile acid binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0035374 chondroitin sulfate binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0047429 nucleoside triphosphate diphosphatase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0051880 G-quadruplex DNA binding 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0070739 protein-glutamic acid ligase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0070740 tubulin-glutamic acid ligase activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0140135 mechanosensitive monoatomic cation channel activity 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/769 10/18639 0.1 2.42379713914174 0.343893552815425 0.785340168641569 GO:0008237 metallopeptidase activity 9/769 184/18639 0.0489130434782609 1.18555294849324 0.349080981992651 0.785340168641569 GO:0000287 magnesium ion binding 11/769 230/18639 0.0478260869565217 1.15920732741562 0.3515479924496 0.785340168641569 GO:0005010 insulin-like growth factor receptor activity 3/769 51/18639 0.0588235294117647 1.42576302302455 0.352069557992771 0.785340168641569 GO:0005030 neurotrophin receptor activity 3/769 51/18639 0.0588235294117647 1.42576302302455 0.352069557992771 0.785340168641569 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/769 30/18639 0.0666666666666667 1.61586475942783 0.352793918401751 0.785340168641569 GO:0033612 receptor serine/threonine kinase binding 2/769 30/18639 0.0666666666666667 1.61586475942783 0.352793918401751 0.785340168641569 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/769 30/18639 0.0666666666666667 1.61586475942783 0.352793918401751 0.785340168641569 GO:0048019 receptor antagonist activity 2/769 30/18639 0.0666666666666667 1.61586475942783 0.352793918401751 0.785340168641569 GO:0070566 adenylyltransferase activity 2/769 30/18639 0.0666666666666667 1.61586475942783 0.352793918401751 0.785340168641569 GO:0015078 proton transmembrane transporter activity 9/769 185/18639 0.0486486486486487 1.17914455417706 0.354929898865106 0.785340168641569 GO:0004896 cytokine receptor activity 5/769 96/18639 0.0520833333333333 1.26239434330299 0.363256578507385 0.785340168641569 GO:0005080 protein kinase C binding 3/769 52/18639 0.0576923076923077 1.39834450335101 0.363446853636998 0.785340168641569 GO:0030159 signaling receptor complex adaptor activity 3/769 52/18639 0.0576923076923077 1.39834450335101 0.363446853636998 0.785340168641569 GO:0008234 cysteine-type peptidase activity 9/769 187/18639 0.0481283422459893 1.16653338247464 0.366664094626623 0.785340168641569 GO:0016411 acylglycerol O-acyltransferase activity 2/769 31/18639 0.0645161290322581 1.56374008976887 0.36785611365101 0.785340168641569 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0002162 dystroglycan binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0004954 prostanoid receptor activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0005114 type II transforming growth factor beta receptor binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0005536 D-glucose binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0008046 axon guidance receptor activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0008432 JUN kinase binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0008526 phosphatidylinositol transfer activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0010854 adenylate cyclase regulator activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0019215 intermediate filament binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0019864 IgG binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0034713 type I transforming growth factor beta receptor binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0043522 leucine zipper domain binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0045294 alpha-catenin binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0048185 activin binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0070697 activin receptor binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0140031 phosphorylation-dependent protein binding 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/769 11/18639 0.0909090909090909 2.20345194467431 0.370977446630709 0.785340168641569 GO:0004864 protein phosphatase inhibitor activity 3/769 53/18639 0.0566037735849057 1.37196064479721 0.374791609493393 0.785340168641569 GO:0005003 ephrin receptor activity 3/769 53/18639 0.0566037735849057 1.37196064479721 0.374791609493393 0.785340168641569 GO:0005005 transmembrane-ephrin receptor activity 3/769 53/18639 0.0566037735849057 1.37196064479721 0.374791609493393 0.785340168641569 GO:0008146 sulfotransferase activity 3/769 53/18639 0.0566037735849057 1.37196064479721 0.374791609493393 0.785340168641569 GO:0043425 bHLH transcription factor binding 2/769 32/18639 0.0625 1.51487321196359 0.38277884113149 0.785340168641569 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/769 54/18639 0.0555555555555556 1.34655396618986 0.386095361332886 0.785340168641569 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/769 54/18639 0.0555555555555556 1.34655396618986 0.386095361332886 0.785340168641569 GO:0050661 NADP binding 3/769 54/18639 0.0555555555555556 1.34655396618986 0.386095361332886 0.785340168641569 GO:0003712 transcription coregulator activity 22/769 495/18639 0.0444444444444444 1.07724317295189 0.390561076591913 0.785340168641569 GO:0008194 UDP-glycosyltransferase activity 7/769 145/18639 0.0482758620689655 1.1701089637236 0.390739293246201 0.785340168641569 GO:0004859 phospholipase inhibitor activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0004875 complement receptor activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0005025 transforming growth factor beta receptor activity, type I 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0005026 transforming growth factor beta receptor activity, type II 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0005078 MAP-kinase scaffold activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0008179 adenylate cyclase binding 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0010853 cyclase activator activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0015132 prostaglandin transmembrane transporter activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0015368 calcium:monoatomic cation antiporter activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0016361 activin receptor activity, type I 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0016362 activin receptor activity, type II 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0016840 carbon-nitrogen lyase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0017002 activin receptor activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0031543 peptidyl-proline dioxygenase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0034452 dynactin binding 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0035259 nuclear glucocorticoid receptor binding 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0045295 gamma-catenin binding 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0070008 serine-type exopeptidase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0070679 inositol 1,4,5 trisphosphate binding 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:1990817 poly(A) RNA polymerase activity 1/769 12/18639 0.0833333333333333 2.01983094928479 0.396944718669629 0.785340168641569 GO:0019239 deaminase activity 2/769 33/18639 0.0606060606060606 1.46896796311621 0.397547973567005 0.785340168641569 GO:0019212 phosphatase inhibitor activity 3/769 56/18639 0.0535714285714286 1.29846275311165 0.408548055582194 0.785688382766136 GO:0090482 vitamin transmembrane transporter activity 2/769 34/18639 0.0588235294117647 1.42576302302455 0.412150783591437 0.785688382766136 GO:0015171 amino acid transmembrane transporter activity 5/769 102/18639 0.0490196078431373 1.18813585252046 0.412706039434271 0.785688382766136 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 11/769 243/18639 0.0452674897119342 1.09719212059914 0.420196816011174 0.785688382766136 GO:0005253 monoatomic anion channel activity 5/769 103/18639 0.0485436893203883 1.17660055298143 0.420907568793721 0.785688382766136 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0004535 poly(A)-specific ribonuclease activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0008253 5'-nucleotidase activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0035673 oligopeptide transmembrane transporter activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0061459 L-arginine transmembrane transporter activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0070123 transforming growth factor beta receptor activity, type III 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0070700 BMP receptor binding 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0071714 icosanoid transmembrane transporter activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0071837 HMG box domain binding 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0140666 annealing activity 1/769 13/18639 0.0769230769230769 1.86445933780134 0.42184134782854 0.785688382766136 GO:0016757 glycosyltransferase activity 12/769 267/18639 0.0449438202247191 1.08934702882775 0.422614245872236 0.785688382766136 GO:0004674 protein serine/threonine kinase activity 19/769 433/18639 0.0438799076212471 1.06355994558183 0.424590286694075 0.785688382766136 GO:0019842 vitamin binding 7/769 150/18639 0.0466666666666667 1.13110533159948 0.424684159151603 0.785688382766136 GO:0030971 receptor tyrosine kinase binding 4/769 81/18639 0.0493827160493827 1.19693685883543 0.430609887089618 0.785688382766136 GO:0004676 3-phosphoinositide-dependent protein kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0004711 ribosomal protein S6 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0035175 histone H3S10 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0035979 histone H2AXS139 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0044022 histone H3S28 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0044023 histone H4S1 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0044024 histone H2AS1 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0044025 histone H2BS14 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0072354 histone H3T3 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0072371 histone H2AS121 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0072518 Rho-dependent protein serine/threonine kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0140823 histone H2BS36 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0140855 histone H3S57 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0140995 histone H2A kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0140997 histone H4 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0140998 histone H2B kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:1990244 histone H2AT120 kinase activity 11/769 245/18639 0.0448979591836735 1.0882354502269 0.43080731295192 0.785688382766136 GO:0031490 chromatin DNA binding 6/769 128/18639 0.046875 1.13615490897269 0.434378064010683 0.785688382766136 GO:0004721 phosphoprotein phosphatase activity 8/769 175/18639 0.0457142857142857 1.10802154932194 0.434842571933096 0.785688382766136 GO:0004677 DNA-dependent protein kinase activity 11/769 246/18639 0.0447154471544715 1.08381172888452 0.436109771740537 0.785688382766136 GO:0140857 histone H3T45 kinase activity 11/769 246/18639 0.0447154471544715 1.08381172888452 0.436109771740537 0.785688382766136 GO:0004033 aldo-keto reductase (NADPH) activity 2/769 36/18639 0.0555555555555556 1.34655396618986 0.440812984371112 0.785688382766136 GO:0055106 ubiquitin-protein transferase regulator activity 2/769 36/18639 0.0555555555555556 1.34655396618986 0.440812984371112 0.785688382766136 GO:0035402 histone H3T11 kinase activity 11/769 247/18639 0.0445344129554656 1.07942382714814 0.441409130224689 0.785688382766136 GO:0035403 histone H3T6 kinase activity 11/769 247/18639 0.0445344129554656 1.07942382714814 0.441409130224689 0.785688382766136 GO:0015459 potassium channel regulator activity 3/769 59/18639 0.0508474576271186 1.23243922329241 0.441731386718504 0.785688382766136 GO:0004497 monooxygenase activity 5/769 106/18639 0.0471698113207547 1.14330053733101 0.445377734770394 0.785688382766136 GO:0005347 ATP transmembrane transporter activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0008331 high voltage-gated calcium channel activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0019763 immunoglobulin receptor activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0019992 diacylglycerol binding 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0043176 amine binding 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0046030 inositol trisphosphate phosphatase activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0061783 peptidoglycan muralytic activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0070742 C2H2 zinc finger domain binding 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0098821 BMP receptor activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:1901474 azole transmembrane transporter activity 1/769 14/18639 0.0714285714285714 1.73128367081553 0.445711422107497 0.785688382766136 GO:0004679 AMP-activated protein kinase activity 11/769 248/18639 0.0443548387096774 1.0750713117161 0.446704469423454 0.786004585542909 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/769 130/18639 0.0461538461538462 1.1186756026808 0.449064817217277 0.78734188832296 GO:0005254 chloride channel activity 4/769 83/18639 0.0481927710843374 1.1680950068153 0.449094596755643 0.78734188832296 GO:0005506 iron ion binding 7/769 154/18639 0.0454545454545455 1.10172597233716 0.451698064860311 0.788768085844044 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/769 60/18639 0.05 1.21189856957087 0.452634057788719 0.788768085844044 GO:0019888 protein phosphatase regulator activity 5/769 107/18639 0.0467289719626168 1.13261548558025 0.453479486362312 0.788768085844044 GO:0022829 wide pore channel activity 2/769 37/18639 0.0540540540540541 1.31016061575229 0.454853124440504 0.788768085844044 GO:0030280 structural constituent of skin epidermis 2/769 37/18639 0.0540540540540541 1.31016061575229 0.454853124440504 0.788768085844044 GO:0030551 cyclic nucleotide binding 2/769 37/18639 0.0540540540540541 1.31016061575229 0.454853124440504 0.788768085844044 GO:0004860 protein kinase inhibitor activity 4/769 84/18639 0.0476190476190476 1.15418911387702 0.458266033098356 0.788768085844044 GO:0051117 ATPase binding 4/769 84/18639 0.0476190476190476 1.15418911387702 0.458266033098356 0.788768085844044 GO:0000774 adenyl-nucleotide exchange factor activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0004089 carbonate dehydratase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0004129 cytochrome-c oxidase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0004953 icosanoid receptor activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0005523 tropomyosin binding 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0008252 nucleotidase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0015929 hexosaminidase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0030553 cGMP binding 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0033130 acetylcholine receptor binding 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0047372 monoacylglycerol lipase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0050780 dopamine receptor binding 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0141050 histone H3K deacetylase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0141051 histone H4K deacetylase activity 1/769 15/18639 0.0666666666666667 1.61586475942783 0.468597216276589 0.788768085844044 GO:0005109 frizzled binding 2/769 38/18639 0.0526315789473684 1.27568270481144 0.468688282892838 0.788768085844044 GO:0005516 calmodulin binding 9/769 207/18639 0.0434782608695652 1.05382484310511 0.48438077028228 0.807258826746375 GO:0019001 guanyl nucleotide binding 17/769 400/18639 0.0425 1.03011378413524 0.485360801028642 0.807258826746375 GO:0032561 guanyl ribonucleotide binding 17/769 400/18639 0.0425 1.03011378413524 0.485360801028642 0.807258826746375 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0005149 interleukin-1 receptor binding 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0005159 insulin-like growth factor receptor binding 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0015562 efflux transmembrane transporter activity 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0017070 U6 snRNA binding 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0030275 LRR domain binding 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0055102 lipase inhibitor activity 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/769 16/18639 0.0625 1.51487321196359 0.490539266356234 0.807258826746375 GO:0043022 ribosome binding 5/769 112/18639 0.0446428571428571 1.08205229425971 0.493448904591699 0.810257573672079 GO:0061791 GTPase motor activity 2/769 40/18639 0.05 1.21189856957087 0.495716590103725 0.810257573672079 GO:0071949 FAD binding 2/769 40/18639 0.05 1.21189856957087 0.495716590103725 0.810257573672079 GO:1990606 membrane scission GTPase motor activity 2/769 40/18639 0.05 1.21189856957087 0.495716590103725 0.810257573672079 GO:0001530 lipopolysaccharide binding 2/769 41/18639 0.0487804878048781 1.18234006787402 0.508898453315057 0.816270783074943 GO:0042169 SH2 domain binding 2/769 41/18639 0.0487804878048781 1.18234006787402 0.508898453315057 0.816270783074943 GO:0042287 MHC protein binding 2/769 41/18639 0.0487804878048781 1.18234006787402 0.508898453315057 0.816270783074943 GO:0140828 metal cation:monoatomic cation antiporter activity 2/769 41/18639 0.0487804878048781 1.18234006787402 0.508898453315057 0.816270783074943 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0004550 nucleoside diphosphate kinase activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0008429 phosphatidylethanolamine binding 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0015278 intracellularly gated calcium channel activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0016018 cyclosporin A binding 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0030548 acetylcholine receptor regulator activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0045125 bioactive lipid receptor activity 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0070403 NAD+ binding 1/769 17/18639 0.0588235294117647 1.42576302302455 0.511576441041949 0.816270783074943 GO:0019210 kinase inhibitor activity 4/769 90/18639 0.0444444444444444 1.07724317295189 0.512070491245772 0.816270783074943 GO:0051879 Hsp90 protein binding 2/769 42/18639 0.0476190476190476 1.15418911387702 0.521852639141183 0.830493656359773 GO:0016500 protein-hormone receptor activity 3/769 67/18639 0.0447761194029851 1.08528230110824 0.526183165149274 0.832025862279532 GO:0004970 glutamate-gated receptor activity 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0015280 ligand-gated sodium channel activity 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0017128 phospholipid scramblase activity 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0031690 adrenergic receptor binding 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0035615 clathrin adaptor activity 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0050811 GABA receptor binding 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0070064 proline-rich region binding 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:1990381 ubiquitin-specific protease binding 1/769 18/18639 0.0555555555555556 1.34655396618986 0.531746010198792 0.832025862279532 GO:0019208 phosphatase regulator activity 5/769 117/18639 0.0427350427350427 1.03581074322297 0.532289837358956 0.832025862279532 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/769 43/18639 0.0465116279069767 1.12734750657755 0.534575477466472 0.832903082633246 GO:0005245 voltage-gated calcium channel activity 2/769 43/18639 0.0465116279069767 1.12734750657755 0.534575477466472 0.832903082633246 GO:0005548 phospholipid transporter activity 3/769 68/18639 0.0441176470588235 1.06932226726842 0.536242316781715 0.834154714993778 GO:0016874 ligase activity 7/769 167/18639 0.0419161676646707 1.01596287269414 0.537207775463132 0.834313040349495 GO:0005261 monoatomic cation channel activity 14/769 341/18639 0.0410557184750733 0.995107329852915 0.546235540847673 0.84365588650873 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0008301 DNA binding, bending 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0008381 mechanosensitive monoatomic ion channel activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0022821 solute:potassium antiporter activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0022840 leak channel activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0022842 narrow pore channel activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0030506 ankyrin binding 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0140036 ubiquitin-modified protein reader activity 1/769 19/18639 0.0526315789473684 1.27568270481144 0.551083710545558 0.84365588650873 GO:0046915 transition metal ion transmembrane transporter activity 2/769 45/18639 0.0444444444444444 1.07724317295189 0.559315826427635 0.853553062131272 GO:0140303 intramembrane lipid transporter activity 2/769 45/18639 0.0444444444444444 1.07724317295189 0.559315826427635 0.853553062131272 GO:0001972 retinoic acid binding 1/769 20/18639 0.05 1.21189856957087 0.569623808643864 0.861004757185053 GO:0015095 magnesium ion transmembrane transporter activity 1/769 20/18639 0.05 1.21189856957087 0.569623808643864 0.861004757185053 GO:0016505 peptidase activator activity involved in apoptotic process 1/769 20/18639 0.05 1.21189856957087 0.569623808643864 0.861004757185053 GO:0042288 MHC class I protein binding 1/769 20/18639 0.05 1.21189856957087 0.569623808643864 0.861004757185053 GO:0052745 inositol phosphate phosphatase activity 1/769 20/18639 0.05 1.21189856957087 0.569623808643864 0.861004757185053 GO:0004180 carboxypeptidase activity 2/769 46/18639 0.0434782608695652 1.05382484310511 0.571329243639357 0.861004757185053 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/769 46/18639 0.0434782608695652 1.05382484310511 0.571329243639357 0.861004757185053 GO:0030291 protein serine/threonine kinase inhibitor activity 2/769 46/18639 0.0434782608695652 1.05382484310511 0.571329243639357 0.861004757185053 GO:0042626 ATPase-coupled transmembrane transporter activity 4/769 98/18639 0.0408163265306122 0.989304954751732 0.579707779510797 0.864981082040098 GO:0005216 monoatomic ion channel activity 18/769 448/18639 0.0401785714285714 0.973847064833736 0.580374940771769 0.864981082040098 GO:0099095 ligand-gated monoatomic anion channel activity 2/769 47/18639 0.0425531914893617 1.03140303793266 0.583103034325151 0.864981082040098 GO:0140359 ABC-type transporter activity 2/769 47/18639 0.0425531914893617 1.03140303793266 0.583103034325151 0.864981082040098 GO:0005267 potassium channel activity 5/769 124/18639 0.0403225806451613 0.977337556105541 0.584272006043939 0.864981082040098 GO:0004521 RNA endonuclease activity 3/769 73/18639 0.0410958904109589 0.996081016085648 0.584645418370651 0.864981082040098 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0008373 sialyltransferase activity 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0010314 phosphatidylinositol-5-phosphate binding 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0015174 basic amino acid transmembrane transporter activity 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0019200 carbohydrate kinase activity 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0035613 RNA stem-loop binding 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0051428 peptide hormone receptor binding 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0070182 DNA polymerase binding 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0140312 cargo adaptor activity 1/769 21/18639 0.0476190476190476 1.15418911387702 0.587399161302593 0.864981082040098 GO:0031491 nucleosome binding 3/769 74/18639 0.0405405405405405 0.98262046181422 0.593931297082917 0.866306038879043 GO:0048029 monosaccharide binding 3/769 74/18639 0.0405405405405405 0.98262046181422 0.593931297082917 0.866306038879043 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/769 48/18639 0.0416666666666667 1.00991547464239 0.594636498334672 0.866306038879043 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/769 48/18639 0.0416666666666667 1.00991547464239 0.594636498334672 0.866306038879043 GO:0032266 phosphatidylinositol-3-phosphate binding 2/769 48/18639 0.0416666666666667 1.00991547464239 0.594636498334672 0.866306038879043 GO:0038187 pattern recognition receptor activity 2/769 48/18639 0.0416666666666667 1.00991547464239 0.594636498334672 0.866306038879043 GO:0043130 ubiquitin binding 4/769 100/18639 0.04 0.969518855656697 0.595759347698791 0.866306038879043 GO:0005525 GTP binding 15/769 378/18639 0.0396825396825397 0.961824261564184 0.598799282501146 0.866306038879043 GO:0043021 ribonucleoprotein complex binding 7/769 177/18639 0.0395480225988701 0.958563840338542 0.599113833980781 0.866306038879043 GO:0003725 double-stranded RNA binding 3/769 75/18639 0.04 0.969518855656697 0.603081334702072 0.866306038879043 GO:0004407 histone deacetylase activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0005243 gap junction channel activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0008970 phospholipase A1 activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0016881 acid-amino acid ligase activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0033558 protein lysine deacetylase activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0033691 sialic acid binding 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0050321 tau-protein kinase activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0140035 ubiquitin-like protein reader activity 1/769 22/18639 0.0454545454545455 1.10172597233716 0.604441273503597 0.866306038879043 GO:0003713 transcription coactivator activity 10/769 256/18639 0.0390625 0.946795757477243 0.615231944771441 0.880465272072906 GO:0000295 adenine nucleotide transmembrane transporter activity 1/769 23/18639 0.0434782608695652 1.05382484310511 0.620780353950272 0.883439876960049 GO:0005283 amino acid:sodium symporter activity 1/769 23/18639 0.0434782608695652 1.05382484310511 0.620780353950272 0.883439876960049 GO:0016849 phosphorus-oxygen lyase activity 1/769 23/18639 0.0434782608695652 1.05382484310511 0.620780353950272 0.883439876960049 GO:0003724 RNA helicase activity 3/769 77/18639 0.038961038961039 0.944336547717562 0.620968609167571 0.883439876960049 GO:0106310 protein serine kinase activity 14/769 361/18639 0.038781163434903 0.939976729861064 0.632253086516915 0.883549181204998 GO:0004806 triacylglycerol lipase activity 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0015149 hexose transmembrane transporter activity 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0019957 C-C chemokine binding 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0030215 semaphorin receptor binding 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0048027 mRNA 5'-UTR binding 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0055056 D-glucose transmembrane transporter activity 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0070300 phosphatidic acid binding 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0070840 dynein complex binding 1/769 24/18639 0.0416666666666667 1.00991547464239 0.636445368336404 0.883549181204998 GO:0008186 ATP-dependent activity, acting on RNA 3/769 79/18639 0.0379746835443038 0.920429293344965 0.638298727555481 0.883549181204998 GO:0016835 carbon-oxygen lyase activity 3/769 79/18639 0.0379746835443038 0.920429293344965 0.638298727555481 0.883549181204998 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/769 52/18639 0.0384615384615385 0.93222966890067 0.638368596926176 0.883549181204998 GO:0005246 calcium channel regulator activity 2/769 53/18639 0.0377358490566038 0.914640429864809 0.648704949374521 0.883549181204998 GO:0017046 peptide hormone binding 2/769 53/18639 0.0377358490566038 0.914640429864809 0.648704949374521 0.883549181204998 GO:0015276 ligand-gated monoatomic ion channel activity 7/769 186/18639 0.0376344086021505 0.912181719031839 0.650961638863683 0.883549181204998 GO:0015079 potassium ion transmembrane transporter activity 6/769 160/18639 0.0375 0.908923927178153 0.651269500195742 0.883549181204998 GO:0000030 mannosyltransferase activity 1/769 25/18639 0.04 0.969518855656697 0.651464090428765 0.883549181204998 GO:0008139 nuclear localization sequence binding 1/769 25/18639 0.04 0.969518855656697 0.651464090428765 0.883549181204998 GO:0008483 transaminase activity 1/769 25/18639 0.04 0.969518855656697 0.651464090428765 0.883549181204998 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/769 25/18639 0.04 0.969518855656697 0.651464090428765 0.883549181204998 GO:0019707 protein-cysteine S-acyltransferase activity 1/769 25/18639 0.04 0.969518855656697 0.651464090428765 0.883549181204998 GO:0033192 calmodulin-dependent protein phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0140791 histone H2AXS140 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/769 81/18639 0.037037037037037 0.897702644126571 0.655066235014144 0.883549181204998 GO:0003925 G protein activity 2/769 54/18639 0.037037037037037 0.897702644126571 0.658805318145352 0.883549181204998 GO:0051287 NAD binding 2/769 54/18639 0.037037037037037 0.897702644126571 0.658805318145352 0.883549181204998 GO:0022834 ligand-gated channel activity 7/769 188/18639 0.0372340425531915 0.902477658191074 0.661927625178525 0.883549181204998 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/769 82/18639 0.0365853658536585 0.886755050905516 0.663238071259879 0.883549181204998 GO:0033549 MAP kinase phosphatase activity 3/769 82/18639 0.0365853658536585 0.886755050905516 0.663238071259879 0.883549181204998 GO:0099094 ligand-gated monoatomic cation channel activity 5/769 136/18639 0.0367647058823529 0.891101889390347 0.665536673257666 0.883549181204998 GO:0004435 phosphatidylinositol phospholipase C activity 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0005112 Notch binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0005160 transforming growth factor beta receptor binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0008066 glutamate receptor activity 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0008143 poly(A) binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0008157 protein phosphatase 1 binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0015145 monosaccharide transmembrane transporter activity 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0015216 purine nucleotide transmembrane transporter activity 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0034237 protein kinase A regulatory subunit binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0051139 metal cation:proton antiporter activity 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0097602 cullin family protein binding 1/769 26/18639 0.0384615384615385 0.93222966890067 0.665863151053042 0.883549181204998 GO:0008374 O-acyltransferase activity 2/769 55/18639 0.0363636363636364 0.881380777869724 0.66867155437864 0.88485090320312 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/769 83/18639 0.036144578313253 0.876071255111473 0.671268451553788 0.88485090320312 GO:0008135 translation factor activity, RNA binding 3/769 83/18639 0.036144578313253 0.876071255111473 0.671268451553788 0.88485090320312 GO:0008514 organic anion transmembrane transporter activity 10/769 269/18639 0.0371747211895911 0.901039828677228 0.67640642110815 0.88485090320312 GO:0170055 lipid transmembrane transporter activity 2/769 56/18639 0.0357142857142857 0.865641835407765 0.678305758037767 0.88485090320312 GO:0017018 myosin phosphatase activity 3/769 84/18639 0.0357142857142857 0.865641835407765 0.6791574300151 0.88485090320312 GO:0180051 translation factor activity 3/769 84/18639 0.0357142857142857 0.865641835407765 0.6791574300151 0.88485090320312 GO:0004364 glutathione transferase activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0005044 scavenger receptor activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0008320 protein transmembrane transporter activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0008395 steroid hydroxylase activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/769 27/18639 0.037037037037037 0.897702644126571 0.679668085069063 0.88485090320312 GO:0019789 SUMO transferase activity 1/769 28/18639 0.0357142857142857 0.865641835407765 0.692903376417757 0.896043723720955 GO:0045499 chemorepellent activity 1/769 28/18639 0.0357142857142857 0.865641835407765 0.692903376417757 0.896043723720955 GO:0050698 proteoglycan sulfotransferase activity 1/769 28/18639 0.0357142857142857 0.865641835407765 0.692903376417757 0.896043723720955 GO:0051119 sugar transmembrane transporter activity 1/769 28/18639 0.0357142857142857 0.865641835407765 0.692903376417757 0.896043723720955 GO:0141052 histone H3 demethylase activity 1/769 28/18639 0.0357142857142857 0.865641835407765 0.692903376417757 0.896043723720955 GO:0016247 channel regulator activity 6/769 168/18639 0.0357142857142857 0.865641835407765 0.696864462447865 0.899961324498179 GO:0101005 deubiquitinase activity 4/769 115/18639 0.0347826086956522 0.843059874484084 0.703801419651164 0.900715780273066 GO:0140104 molecular carrier activity 9/769 249/18639 0.036144578313253 0.876071255111473 0.703802732185681 0.900715780273066 GO:0004181 metallocarboxypeptidase activity 1/769 29/18639 0.0344827586206897 0.835792116945428 0.705592501318877 0.900715780273066 GO:0005416 amino acid:monoatomic cation symporter activity 1/769 29/18639 0.0344827586206897 0.835792116945428 0.705592501318877 0.900715780273066 GO:0016417 S-acyltransferase activity 1/769 29/18639 0.0344827586206897 0.835792116945428 0.705592501318877 0.900715780273066 GO:0035250 UDP-galactosyltransferase activity 1/769 29/18639 0.0344827586206897 0.835792116945428 0.705592501318877 0.900715780273066 GO:0031593 polyubiquitin modification-dependent protein binding 2/769 59/18639 0.0338983050847458 0.821626148861608 0.705840419944835 0.900715780273066 GO:0036002 pre-mRNA binding 2/769 59/18639 0.0338983050847458 0.821626148861608 0.705840419944835 0.900715780273066 GO:0070063 RNA polymerase binding 2/769 59/18639 0.0338983050847458 0.821626148861608 0.705840419944835 0.900715780273066 GO:0141108 transporter regulator activity 6/769 170/18639 0.0352941176470588 0.855457813814733 0.707617957008484 0.901792805369651 GO:0016758 hexosyltransferase activity 7/769 197/18639 0.0355329949238579 0.861247714415848 0.708613265399904 0.901871428690787 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/769 30/18639 0.0333333333333333 0.807932379713914 0.71775796969533 0.907531673724724 GO:0015215 nucleotide transmembrane transporter activity 1/769 30/18639 0.0333333333333333 0.807932379713914 0.71775796969533 0.907531673724724 GO:0016769 transferase activity, transferring nitrogenous groups 1/769 30/18639 0.0333333333333333 0.807932379713914 0.71775796969533 0.907531673724724 GO:0031624 ubiquitin conjugating enzyme binding 1/769 30/18639 0.0333333333333333 0.807932379713914 0.71775796969533 0.907531673724724 GO:0032452 histone demethylase activity 1/769 30/18639 0.0333333333333333 0.807932379713914 0.71775796969533 0.907531673724724 GO:0016836 hydro-lyase activity 2/769 61/18639 0.0327868852459016 0.79468758660385 0.723084351815997 0.913071220724513 GO:0030695 GTPase regulator activity 18/769 489/18639 0.0368098159509202 0.892195265941746 0.724172019153349 0.913250875329158 GO:0060589 nucleoside-triphosphatase regulator activity 18/769 490/18639 0.036734693877551 0.890374459276559 0.727270045459607 0.915092257779631 GO:0047499 calcium-independent phospholipase A2 activity 1/769 31/18639 0.032258064516129 0.781870044884433 0.729421364896807 0.915092257779631 GO:0072349 modified amino acid transmembrane transporter activity 1/769 31/18639 0.032258064516129 0.781870044884433 0.729421364896807 0.915092257779631 GO:0140457 protein demethylase activity 1/769 31/18639 0.032258064516129 0.781870044884433 0.729421364896807 0.915092257779631 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/769 91/18639 0.032967032967033 0.79905400191486 0.730453156633004 0.915198118427343 GO:0032182 ubiquitin-like protein binding 4/769 120/18639 0.0333333333333333 0.807932379713914 0.734785179203658 0.915388756364425 GO:0052689 carboxylic ester hydrolase activity 3/769 92/18639 0.0326086956521739 0.790368632328829 0.737228153690433 0.915388756364425 GO:0008378 galactosyltransferase activity 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0015106 bicarbonate transmembrane transporter activity 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0022884 macromolecule transmembrane transporter activity 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0031369 translation initiation factor binding 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0047498 calcium-dependent phospholipase A2 activity 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0070717 poly-purine tract binding 1/769 32/18639 0.03125 0.757436605981795 0.740603381792462 0.915388756364425 GO:0004540 RNA nuclease activity 4/769 121/18639 0.0330578512396694 0.80125525260884 0.740679774513661 0.915388756364425 GO:0015108 chloride transmembrane transporter activity 4/769 121/18639 0.0330578512396694 0.80125525260884 0.740679774513661 0.915388756364425 GO:0008509 monoatomic anion transmembrane transporter activity 5/769 149/18639 0.0335570469798658 0.813354744678437 0.741028993247392 0.915388756364425 GO:0051213 dioxygenase activity 3/769 93/18639 0.032258064516129 0.781870044884433 0.743867677594502 0.917721809139577 GO:0008528 G protein-coupled peptide receptor activity 4/769 122/18639 0.0327868852459016 0.79468758660385 0.746474528868635 0.919763258784568 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/769 33/18639 0.0303030303030303 0.734483981558104 0.751323863299508 0.924559047066656 GO:0015020 glucuronosyltransferase activity 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0015035 protein-disulfide reductase activity 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0016831 carboxy-lyase activity 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0030332 cyclin binding 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0051427 hormone receptor binding 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/769 34/18639 0.0294117647058824 0.712881511512277 0.761601835411874 0.928923450767513 GO:0046873 metal ion transmembrane transporter activity 16/769 450/18639 0.0355555555555556 0.861794538361508 0.764109663635941 0.930150168878842 GO:0022836 gated channel activity 11/769 318/18639 0.0345911949685535 0.838420394042741 0.766194550839071 0.930150168878842 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/769 67/18639 0.0298507462686567 0.723521534072162 0.769753652916806 0.930150168878842 GO:0000175 3'-5'-RNA exonuclease activity 1/769 35/18639 0.0285714285714286 0.692513468326212 0.771455540790442 0.930150168878842 GO:0004623 phospholipase A2 activity 1/769 35/18639 0.0285714285714286 0.692513468326212 0.771455540790442 0.930150168878842 GO:0005343 organic acid:sodium symporter activity 1/769 35/18639 0.0285714285714286 0.692513468326212 0.771455540790442 0.930150168878842 GO:0140566 histone reader activity 1/769 35/18639 0.0285714285714286 0.692513468326212 0.771455540790442 0.930150168878842 GO:0019783 ubiquitin-like protein peptidase activity 4/769 127/18639 0.031496062992126 0.763400673745431 0.773969642968162 0.930150168878842 GO:0008170 N-methyltransferase activity 3/769 98/18639 0.0306122448979592 0.741978716063799 0.775075551203232 0.930150168878842 GO:0001653 peptide receptor activity 4/769 128/18639 0.03125 0.757436605981795 0.779177397961857 0.930150168878842 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/769 128/18639 0.03125 0.757436605981795 0.779177397961857 0.930150168878842 GO:0000993 RNA polymerase II complex binding 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0016409 palmitoyltransferase activity 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0045505 dynein intermediate chain binding 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/769 36/18639 0.0277777777777778 0.673276983094928 0.780902470973852 0.930150168878842 GO:0002039 p53 binding 2/769 69/18639 0.0289855072463768 0.702549895403404 0.783714856900431 0.932350433209134 GO:0016298 lipase activity 4/769 130/18639 0.0307692307692308 0.745783735120536 0.789307513625002 0.937410156434343 GO:0019213 deacetylase activity 1/769 37/18639 0.027027027027027 0.655080307876147 0.789959397266445 0.937410156434343 GO:0005096 GTPase activator activity 9/769 271/18639 0.033210332103321 0.804951079419767 0.791277421940764 0.937410156434343 GO:0140597 protein carrier chaperone 6/769 188/18639 0.0319148936170213 0.773552278449492 0.792605377308131 0.937410156434343 GO:0099106 ion channel regulator activity 5/769 160/18639 0.03125 0.757436605981795 0.79449219749164 0.937410156434343 GO:0140299 molecular sensor activity 2/769 71/18639 0.028169014084507 0.682759757504716 0.796926853302451 0.937410156434343 GO:0008238 exopeptidase activity 3/769 102/18639 0.0294117647058824 0.712881511512277 0.797737064970293 0.937410156434343 GO:0000146 microfilament motor activity 1/769 38/18639 0.0263157894736842 0.637841352405722 0.798642400357624 0.937410156434343 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/769 38/18639 0.0263157894736842 0.637841352405722 0.798642400357624 0.937410156434343 GO:0042887 amide transmembrane transporter activity 1/769 38/18639 0.0263157894736842 0.637841352405722 0.798642400357624 0.937410156434343 GO:0043531 ADP binding 1/769 38/18639 0.0263157894736842 0.637841352405722 0.798642400357624 0.937410156434343 GO:0004722 protein serine/threonine phosphatase activity 3/769 103/18639 0.029126213592233 0.705960331788857 0.80309501750584 0.941492459843012 GO:0000217 DNA secondary structure binding 1/769 39/18639 0.0256410256410256 0.62148644593378 0.806966898724646 0.942599787385741 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/769 39/18639 0.0256410256410256 0.62148644593378 0.806966898724646 0.942599787385741 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/769 39/18639 0.0256410256410256 0.62148644593378 0.806966898724646 0.942599787385741 GO:0140713 histone chaperone activity 5/769 164/18639 0.0304878048780488 0.738962542421263 0.811650456839596 0.944462085066684 GO:0004532 RNA exonuclease activity 1/769 40/18639 0.025 0.605949284785436 0.814947675868772 0.944462085066684 GO:0015036 disulfide oxidoreductase activity 1/769 40/18639 0.025 0.605949284785436 0.814947675868772 0.944462085066684 GO:0015144 carbohydrate transmembrane transporter activity 1/769 40/18639 0.025 0.605949284785436 0.814947675868772 0.944462085066684 GO:0030331 nuclear estrogen receptor binding 1/769 40/18639 0.025 0.605949284785436 0.814947675868772 0.944462085066684 GO:0032451 demethylase activity 1/769 40/18639 0.025 0.605949284785436 0.814947675868772 0.944462085066684 GO:0003678 DNA helicase activity 2/769 74/18639 0.027027027027027 0.655080307876147 0.815405154188007 0.944462085066684 GO:0016887 ATP hydrolysis activity 14/769 417/18639 0.0335731414868106 0.813744842877324 0.8207650796018 0.947116261756742 GO:0016922 nuclear receptor binding 4/769 137/18639 0.0291970802919708 0.707677996829706 0.821857264226952 0.947116261756742 GO:0001727 lipid kinase activity 1/769 41/18639 0.024390243902439 0.59117003393701 0.822598906432615 0.947116261756742 GO:0008227 G protein-coupled amine receptor activity 1/769 41/18639 0.024390243902439 0.59117003393701 0.822598906432615 0.947116261756742 GO:0140318 protein transporter activity 1/769 41/18639 0.024390243902439 0.59117003393701 0.822598906432615 0.947116261756742 GO:0004843 cysteine-type deubiquitinase activity 3/769 108/18639 0.0277777777777778 0.673276983094928 0.828123333474457 0.952157267318628 GO:0016859 cis-trans isomerase activity 1/769 42/18639 0.0238095238095238 0.57709455693851 0.829934181244601 0.952157267318628 GO:0043175 RNA polymerase core enzyme binding 1/769 42/18639 0.0238095238095238 0.57709455693851 0.829934181244601 0.952157267318628 GO:0004620 phospholipase activity 3/769 109/18639 0.0275229357798165 0.667100130039012 0.832788832887468 0.954298947294537 GO:0008375 acetylglucosaminyltransferase activity 1/769 43/18639 0.0232558139534884 0.563673753288777 0.836966531334557 0.95667930592451 GO:0046982 protein heterodimerization activity 12/769 369/18639 0.032520325203252 0.788226711916014 0.83779368845848 0.95667930592451 GO:0016829 lyase activity 6/769 200/18639 0.03 0.727139141742523 0.837837156120223 0.95667930592451 GO:0051020 GTPase binding 10/769 315/18639 0.0317460317460317 0.769459409251347 0.841700666796931 0.959956132379971 GO:0016248 channel inhibitor activity 1/769 44/18639 0.0227272727272727 0.550862986168578 0.843708450962634 0.959979226890347 GO:0019205 nucleobase-containing compound kinase activity 1/769 44/18639 0.0227272727272727 0.550862986168578 0.843708450962634 0.959979226890347 GO:0005244 voltage-gated monoatomic ion channel activity 5/769 173/18639 0.0289017341040462 0.700519404376226 0.84607269665329 0.960720595981788 GO:0022843 voltage-gated monoatomic cation channel activity 4/769 143/18639 0.027972027972028 0.677985213745942 0.846349096460146 0.960720595981788 GO:0051539 4 iron, 4 sulfur cluster binding 1/769 45/18639 0.0222222222222222 0.538621586475943 0.850171919702066 0.962797273660253 GO:0141110 transporter inhibitor activity 1/769 45/18639 0.0222222222222222 0.538621586475943 0.850171919702066 0.962797273660253 GO:0022804 active transmembrane transporter activity 15/769 457/18639 0.0328227571115974 0.79555704785834 0.851250957432604 0.962890427259831 GO:0022832 voltage-gated channel activity 5/769 175/18639 0.0285714285714286 0.692513468326212 0.852973702328284 0.96371063912178 GO:0030165 PDZ domain binding 2/769 83/18639 0.0240963855421687 0.584047503407649 0.862126188617818 0.968593570217155 GO:0001784 phosphotyrosine residue binding 1/769 47/18639 0.0212765957446809 0.515701518966328 0.862308975555645 0.968593570217155 GO:0043495 protein-membrane adaptor activity 1/769 47/18639 0.0212765957446809 0.515701518966328 0.862308975555645 0.968593570217155 GO:0061749 forked DNA-dependent helicase activity 1/769 47/18639 0.0212765957446809 0.515701518966328 0.862308975555645 0.968593570217155 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/769 47/18639 0.0212765957446809 0.515701518966328 0.862308975555645 0.968593570217155 GO:0004527 exonuclease activity 2/769 84/18639 0.0238095238095238 0.57709455693851 0.866588841266665 0.969354906436425 GO:0008188 neuropeptide receptor activity 1/769 48/18639 0.0208333333333333 0.504957737321196 0.868004134645453 0.969354906436425 GO:0009378 four-way junction helicase activity 1/769 48/18639 0.0208333333333333 0.504957737321196 0.868004134645453 0.969354906436425 GO:0036121 double-stranded DNA helicase activity 1/769 48/18639 0.0208333333333333 0.504957737321196 0.868004134645453 0.969354906436425 GO:0043138 3'-5' DNA helicase activity 1/769 48/18639 0.0208333333333333 0.504957737321196 0.868004134645453 0.969354906436425 GO:0016853 isomerase activity 5/769 180/18639 0.0277777777777778 0.673276983094928 0.86910640361123 0.969457339188536 GO:0000510 H3-H4 histone complex chaperone activity 4/769 151/18639 0.0264900662251656 0.642065467322316 0.874532113825341 0.969457339188536 GO:0140584 chromatin extrusion motor activity 4/769 151/18639 0.0264900662251656 0.642065467322316 0.874532113825341 0.969457339188536 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 4/769 151/18639 0.0264900662251656 0.642065467322316 0.874532113825341 0.969457339188536 GO:0140849 ATP-dependent H2AZ histone chaperone activity 4/769 151/18639 0.0264900662251656 0.642065467322316 0.874532113825341 0.969457339188536 GO:0005543 phospholipid binding 16/769 497/18639 0.0321931589537223 0.780296865719676 0.876484514829036 0.969457339188536 GO:0015616 DNA translocase activity 4/769 152/18639 0.0263157894736842 0.637841352405722 0.877720975415376 0.969457339188536 GO:0140674 ATP-dependent histone chaperone activity 4/769 152/18639 0.0263157894736842 0.637841352405722 0.877720975415376 0.969457339188536 GO:0015605 organophosphate ester transmembrane transporter activity 1/769 50/18639 0.02 0.484759427828349 0.878698353332319 0.969457339188536 GO:0003774 cytoskeletal motor activity 4/769 153/18639 0.0261437908496732 0.63367245467758 0.880839428968621 0.969457339188536 GO:0061775 cohesin loader activity 4/769 153/18639 0.0261437908496732 0.63367245467758 0.880839428968621 0.969457339188536 GO:0003743 translation initiation factor activity 1/769 51/18639 0.0196078431372549 0.475254341008185 0.88371642672451 0.969457339188536 GO:0005048 signal sequence binding 1/769 51/18639 0.0196078431372549 0.475254341008185 0.88371642672451 0.969457339188536 GO:0005272 sodium channel activity 1/769 51/18639 0.0196078431372549 0.475254341008185 0.88371642672451 0.969457339188536 GO:0016830 carbon-carbon lyase activity 1/769 51/18639 0.0196078431372549 0.475254341008185 0.88371642672451 0.969457339188536 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/769 122/18639 0.0245901639344262 0.596015689952888 0.884153121972153 0.969457339188536 GO:0004386 helicase activity 4/769 155/18639 0.0258064516129032 0.625496035907546 0.886869694721544 0.970374593070567 GO:0008017 microtubule binding 8/769 276/18639 0.0289855072463768 0.702549895403404 0.886998722237382 0.970374593070567 GO:0046943 carboxylic acid transmembrane transporter activity 5/769 188/18639 0.0265957446808511 0.64462689870791 0.891799784640912 0.970497641927244 GO:0005544 calcium-dependent phospholipid binding 1/769 53/18639 0.0188679245283019 0.457320214932404 0.893139134237392 0.970497641927244 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/769 53/18639 0.0188679245283019 0.457320214932404 0.893139134237392 0.970497641927244 GO:0051018 protein kinase A binding 1/769 53/18639 0.0188679245283019 0.457320214932404 0.893139134237392 0.970497641927244 GO:1901505 carbohydrate derivative transmembrane transporter activity 1/769 53/18639 0.0188679245283019 0.457320214932404 0.893139134237392 0.970497641927244 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/769 53/18639 0.0188679245283019 0.457320214932404 0.893139134237392 0.970497641927244 GO:0005342 organic acid transmembrane transporter activity 5/769 189/18639 0.0264550264550265 0.641216174376122 0.894383672344794 0.970758008410192 GO:0140658 ATP-dependent chromatin remodeler activity 4/769 158/18639 0.0253164556962025 0.613619528896644 0.895415605985491 0.970787289991003 GO:0017069 snRNA binding 1/769 54/18639 0.0185185185185185 0.448851322063286 0.897560526993845 0.972021826318446 GO:0004519 endonuclease activity 3/769 127/18639 0.0236220472440945 0.572550505309073 0.899825988194377 0.973340201709148 GO:0003689 DNA clamp loader activity 4/769 160/18639 0.025 0.605949284785436 0.900793105929584 0.973340201709148 GO:0031267 small GTPase binding 8/769 283/18639 0.0282685512367491 0.685172336153143 0.901948164729284 0.973499359920099 GO:0016410 N-acyltransferase activity 2/769 94/18639 0.0212765957446809 0.515701518966328 0.904440705833008 0.974421575251969 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/769 56/18639 0.0178571428571429 0.432820917703883 0.905862729010707 0.974421575251969 GO:0016798 hydrolase activity, acting on glycosyl bonds 3/769 130/18639 0.0230769230769231 0.559337801340402 0.908287040518772 0.974421575251969 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/769 57/18639 0.0175438596491228 0.425227568270481 0.909758308916576 0.974421575251969 GO:0016407 acetyltransferase activity 2/769 96/18639 0.0208333333333333 0.504957737321196 0.910694231059458 0.974421575251969 GO:0015103 inorganic anion transmembrane transporter activity 4/769 165/18639 0.0242424242424242 0.587587185246483 0.913182699759884 0.974421575251969 GO:0008408 3'-5' exonuclease activity 1/769 58/18639 0.0172413793103448 0.417896058472714 0.913492883259658 0.974421575251969 GO:0017116 single-stranded DNA helicase activity 1/769 58/18639 0.0172413793103448 0.417896058472714 0.913492883259658 0.974421575251969 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3/769 132/18639 0.0227272727272727 0.550862986168578 0.913562486534514 0.974421575251969 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/769 229/18639 0.0262008733624454 0.635056018989103 0.914823133302302 0.974421575251969 GO:0005249 voltage-gated potassium channel activity 2/769 98/18639 0.0204081632653061 0.494652477375866 0.91656276363124 0.974421575251969 GO:0005085 guanyl-nucleotide exchange factor activity 6/769 230/18639 0.0260869565217391 0.632294905863063 0.916787768551598 0.974421575251969 GO:0045309 protein phosphorylated amino acid binding 1/769 59/18639 0.0169491525423729 0.410813074430804 0.917073098144397 0.974421575251969 GO:0001098 basal transcription machinery binding 1/769 60/18639 0.0166666666666667 0.403966189856957 0.920505325675449 0.974421575251969 GO:0001099 basal RNA polymerase II transcription machinery binding 1/769 60/18639 0.0166666666666667 0.403966189856957 0.920505325675449 0.974421575251969 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 1/769 60/18639 0.0166666666666667 0.403966189856957 0.920505325675449 0.974421575251969 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/769 60/18639 0.0166666666666667 0.403966189856957 0.920505325675449 0.974421575251969 GO:0015297 antiporter activity 3/769 135/18639 0.0222222222222222 0.538621586475943 0.920959521951395 0.974421575251969 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1/769 61/18639 0.0163934426229508 0.397343793301925 0.923795675239773 0.976352978426281 GO:0022824 transmitter-gated monoatomic ion channel activity 1/769 63/18639 0.0158730158730159 0.384729704625673 0.929973928891375 0.978789573774754 GO:0022835 transmitter-gated channel activity 1/769 63/18639 0.0158730158730159 0.384729704625673 0.929973928891375 0.978789573774754 GO:1901682 sulfur compound transmembrane transporter activity 1/769 63/18639 0.0158730158730159 0.384729704625673 0.929973928891375 0.978789573774754 GO:0140030 modification-dependent protein binding 4/769 173/18639 0.023121387283237 0.560415523500981 0.930154067003338 0.978789573774754 GO:0038024 cargo receptor activity 1/769 65/18639 0.0153846153846154 0.372891867560268 0.935651879952174 0.981633866220806 GO:0160215 deacylase activity 1/769 65/18639 0.0153846153846154 0.372891867560268 0.935651879952174 0.981633866220806 GO:0004518 nuclease activity 5/769 209/18639 0.0239234449760766 0.579855774914293 0.93590558052729 0.981633866220806 GO:0008235 metalloexopeptidase activity 1/769 66/18639 0.0151515151515152 0.367241990779052 0.938316018227009 0.983094656840879 GO:0003777 microtubule motor activity 1/769 68/18639 0.0147058823529412 0.356440755756139 0.943318355241775 0.985450743995803 GO:0140223 general transcription initiation factor activity 1/769 68/18639 0.0147058823529412 0.356440755756139 0.943318355241775 0.985450743995803 GO:0008080 N-acetyltransferase activity 1/769 69/18639 0.0144927536231884 0.351274947701702 0.945665465511501 0.985450743995803 GO:0016279 protein-lysine N-methyltransferase activity 1/769 69/18639 0.0144927536231884 0.351274947701702 0.945665465511501 0.985450743995803 GO:0098960 postsynaptic neurotransmitter receptor activity 1/769 69/18639 0.0144927536231884 0.351274947701702 0.945665465511501 0.985450743995803 GO:1902936 phosphatidylinositol bisphosphate binding 2/769 111/18639 0.018018018018018 0.436720205250764 0.946707593700539 0.985473637408104 GO:0016278 lysine N-methyltransferase activity 1/769 70/18639 0.0142857142857143 0.346256734163106 0.947915506277341 0.985668868744792 GO:0035091 phosphatidylinositol binding 7/769 284/18639 0.0246478873239437 0.597414787816627 0.95112626839423 0.987944059428846 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/769 73/18639 0.0136986301369863 0.332027005361883 0.954122486281067 0.989991752682611 GO:0035064 methylated histone binding 1/769 74/18639 0.0135135135135135 0.327540153938073 0.956022723706999 0.990899089164121 GO:0051536 iron-sulfur cluster binding 1/769 76/18639 0.0131578947368421 0.318920676202861 0.959590618412355 0.992467384781943 GO:0140034 methylation-dependent protein binding 1/769 76/18639 0.0131578947368421 0.318920676202861 0.959590618412355 0.992467384781943 GO:0051540 metal cluster binding 1/769 77/18639 0.012987012987013 0.314778849239187 0.961264637398559 0.993135443558297 GO:0015370 solute:sodium symporter activity 1/769 79/18639 0.0126582278481013 0.306809764448322 0.964407750648009 0.995318255476471 GO:0015081 sodium ion transmembrane transporter activity 3/769 164/18639 0.0182926829268293 0.443377525452758 0.967785583455265 0.997738392334884 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/769 167/18639 0.0179640718562874 0.435412659726062 0.970729794159413 0.999706802940291 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/769 86/18639 0.0116279069767442 0.281836876644389 0.973533841749131 0.999999158254788 GO:0008094 ATP-dependent activity, acting on DNA 4/769 210/18639 0.019047619047619 0.461675645550808 0.975862658351446 0.999999158254788 GO:0003727 single-stranded RNA binding 1/769 89/18639 0.0112359550561798 0.272336757206937 0.976690455686091 0.999999158254788 GO:0016779 nucleotidyltransferase activity 2/769 136/18639 0.0147058823529412 0.356440755756139 0.97807817608725 0.999999158254788 GO:0051219 phosphoprotein binding 1/769 93/18639 0.010752688172043 0.260623348294811 0.980322189249514 0.999999158254788 GO:0008276 protein methyltransferase activity 1/769 95/18639 0.0105263157894737 0.255136540962289 0.981920259181504 0.999999158254788 GO:0030594 neurotransmitter receptor activity 1/769 97/18639 0.0103092783505155 0.249875993725953 0.983388702026633 0.999999158254788 GO:1901981 phosphatidylinositol phosphate binding 3/769 185/18639 0.0162162162162162 0.393048184725688 0.983694223347279 0.999999158254788 GO:0015293 symporter activity 2/769 146/18639 0.0136986301369863 0.332027005361883 0.984753594732883 0.999999158254788 GO:0008168 methyltransferase activity 3/769 204/18639 0.0147058823529412 0.356440755756139 0.991350742952669 0.999999158254788 GO:0140098 catalytic activity, acting on RNA 8/769 387/18639 0.020671834625323 0.501043336256691 0.991420129744447 0.999999158254788 GO:0015294 solute:monoatomic cation symporter activity 1/769 116/18639 0.00862068965517241 0.208948029236357 0.992574780897945 0.999999158254788 GO:0015291 secondary active transmembrane transporter activity 5/769 287/18639 0.0174216027874564 0.422264309955007 0.992764088392049 0.999999158254788 GO:0016755 aminoacyltransferase activity 11/769 496/18639 0.0221774193548387 0.537535655858048 0.993136967750983 0.999999158254788 GO:0003697 single-stranded DNA binding 1/769 121/18639 0.00826446280991736 0.20031381315221 0.993993471250262 0.999999158254788 GO:0016741 transferase activity, transferring one-carbon groups 3/769 215/18639 0.013953488372093 0.338204251973266 0.994048523294632 0.999999158254788 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/769 122/18639 0.00819672131147541 0.198671896650962 0.994242905347278 0.999999158254788 GO:0003730 mRNA 3'-UTR binding 4/769 262/18639 0.0152671755725191 0.370045364754464 0.995202970410656 0.999999158254788 GO:0019787 ubiquitin-like protein transferase activity 10/769 479/18639 0.0208768267223382 0.506011928839612 0.995385519046919 0.999999158254788 GO:0004842 ubiquitin-protein transferase activity 9/769 449/18639 0.0200445434298441 0.485839070206585 0.99583586552487 0.999999158254788 GO:0061630 ubiquitin protein ligase activity 6/769 353/18639 0.0169971671388102 0.411976850845622 0.996927030551349 0.999999158254788 GO:0140101 catalytic activity, acting on a tRNA 1/769 139/18639 0.00719424460431655 0.174373894902284 0.99720163366126 0.999999158254788 GO:0140767 enzyme-substrate adaptor activity 1/769 139/18639 0.00719424460431655 0.174373894902284 0.99720163366126 0.999999158254788 GO:0061659 ubiquitin-like protein ligase activity 6/769 372/18639 0.0161290322580645 0.390935022442217 0.998258977479854 0.999999158254788 GO:0140097 catalytic activity, acting on DNA 5/769 336/18639 0.0148809523809524 0.360684098086569 0.998401767600937 0.999999158254788 GO:0042393 histone binding 2/769 247/18639 0.00809716599190283 0.196258877663299 0.999668339029075 0.999999158254788 GO:0045182 translation regulator activity 2/769 356/18639 0.00561797752808989 0.136168378603469 0.999995608666129 0.999999158254788 GO:0030371 translation repressor activity 1/769 329/18639 0.00303951367781155 0.0736716455666183 0.999999158254788 0.999999158254788