category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/587	203/9376	3.22602193670748	EMP1/ITGB6/LAMB3/DIAPH1/ITGA2/COL4A6/LAMA3/CAPN2/ITGA3/FYN/ITGB4/MYLK/BRAF/MET/CAV2/THBS1/TNC/FLNA/LAMA5/COL4A5/THBS3/RAC2/MAPK8/PRKCB/BCL2/COL1A2/PRKCA/VCL/RAP1B/LAMB1/ITGB1/GSK3B/ITGA1/MYL12A/FLNB/ERBB2/MAPK1/PPP1R12B/ACTB/PXN/ITGB7	8.28622494087411
NA	NA	hsa04382	Cornified envelope formation	40/587	217/9376	2.94428437968582	KRT6A/KRT24/S100A4/SPRR3/KRT5/KRT17/KRT14/S100A14/COL7A1/S100A6/EVPL/PPL/DSG1/S100A16/LAMB3/COL4A6/COL17A1/LAMA3/ABCA12/KRT16/S100A2/ITGB4/PKP1/S100A3/S100A10/PLEC/KRT81/S100A9/DSG3/LAMA5/COL4A5/KRT18/PPP2R3A/KRT15/KRT86/PPP2R2B/PRSS8/DST/PPP2R5A/S100A5	7.4885990948947
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/587	204/9376	2.81871931055216	LUM/DCN/WNT5A/SDC1/ITGA2/CD63/WNT2/BRAF/MET/CAV2/THBS1/GPC1/IQGAP1/FLNA/ITPR3/CAMK2D/PRKCB/WNT7A/COL1A2/PRKCA/HPSE/ITGB1/CD44/MSN/TGFB1/ERBB2/MAPK1/PPP1R12B/FAS/ACTB/FZD6/CDKN1A/EZR/PXN/FASLG/ITPR1	6.78709136133618
NA	NA	hsa04518	Integrin signaling	29/587	154/9376	3.0078541560654	ITGB6/LAMB3/ITGA2/COL4A6/LAMA3/ITGA3/ITGB4/MET/THBS1/TNC/FLNA/LAMA5/COL4A5/THBS3/RAC2/COL1A2/VCL/ITGAD/LAMB1/ITGB1/TGFB1/GSK3B/ITGA1/FLNB/ERBB2/ITGAX/ACTB/PXN/ITGB7	6.49254430542508
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/587	233/9376	2.53644412923792	VIM/DCN/ITGB6/PDLIM4/SDC1/DIAPH1/ITGA2/COL4A6/MYH14/ITGA3/TRIM55/NEBL/ITGB4/THBS1/SPTBN1/COL3A1/COL5A1/TNNT1/PLEC/MYH15/ANKRD2/COL4A5/THBS3/NID2/PDLIM5/TMOD3/COL1A2/VCL/SYNE2/ITGB1/PDLIM2/ITGA1/SGCE/MYH9/ACTB/COL5A2/ITGB7	6.13741272660384
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/587	93/9376	3.60674836511513	SNAI2/FYN/YES1/NECTIN3/ARHGAP29/MET/LMO7/NECTIN4/FER/SMURF2/HEG1/IQGAP1/RAC2/TGFBR2/VCL/RAP1B/MYL12A/ERBB2/MAPK1/ACTB/RASIP1	6.52876994322718
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/587	89/9376	3.58938039545968	ITGB6/LAMB3/SDC1/ITGA2/COL4A6/LAMA3/ITGA3/ITGB4/THBS1/TNC/LAMA5/COL4A5/THBS3/COL1A2/LAMB1/ITGB1/CD44/ITGA1/GP1BB/ITGB7	6.34290333288749
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	34/587	232/9376	2.3408329906597	ITGB6/CYRIB/TMSB4X/RGCC/DIAPH1/ITGA2/MYH14/ITGA3/ITGB4/MYLK/BRAF/SSH2/IQGAP1/RAC2/PIP4K2A/GSN/VCL/ITGAD/ITGB1/MSN/ACTR3/ITGA1/MYL12A/ITGAX/MAPK1/MYH9/PPP1R12B/ACTB/EZR/PXN/ITGB7/ARHGEF7/PFN2/CXCR4	5.34423475938689
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/587	101/9376	3.16291935837536	F3/DIAPH1/COL4A6/EDN1/PRKCE/PLCD3/COL3A1/NFKB1/COL4A5/MAPK8/PRKCB/TGFBR2/BCL2/COL1A2/PLCD1/PRKCA/TGFB1/MAPK1/STAT1/JAK2	5.64779613637617
NA	NA	hsa04517	IgSF CAM signaling	40/587	299/9376	2.13682177388569	SLIT2/KIRREL3/SLITRK6/MYH14/CD96/FYN/NECTIN3/MYLK/MBP/LMO7/SPTBN1/NECTIN4/IQGAP1/TUBA4A/RAPGEF2/CD48/MAPK8/PRKCB/CDH2/NCAM1/PRKCA/VCL/RAP1B/PTPRS/ITGB1/MSN/ACTR3/GSK3B/MYL6/MYL12A/CASK/TRIO/ITGAX/MAPK1/MYH9/SH2D1B/ACTB/SLIT3/EZR/PXN	5.16287685290742
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/587	134/9376	2.74159017518879	AVPR1A/KCNMA1/MYH14/EDN1/PLA2G6/MYLK/PRKCE/BRAF/GNAQ/PRKCH/ADRA1B/EDN2/ITPR3/PRKCB/CALM1/PRKCA/KCNMB4/MYL6/MAPK1/MYH9/PPP1R12B/ADCY3/ITPR1	5.2474745353357
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	28/587	184/9376	2.43063476779498	SLIT2/WNT5A/EFNA5/SEMA5A/PPP3CA/FYN/MET/ABLIM3/SSH2/NGEF/RAC2/SEMA3C/PPP3CC/CAMK2D/RHOD/EPHA2/PRKCA/NFATC3/SEMA3B/ITGB1/GSK3B/MYL12A/EFNB2/RGS3/MAPK1/SEMA4D/SLIT3/CXCR4	5.06486221733036
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/587	67/9376	3.57598718502886	PPP3CA/BRAF/GNAQ/ITPR3/PPP3CC/CAMK2D/PRKCB/CALM1/PRKCA/CAMK4/RAP1B/RPS6KA3/MAPK1/RPS6KA2/ITPR1	5.46845371956386
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/587	253/9376	2.14653460013063	H3-3B/DIAPH1/H3C4/CAPN2/PRKCE/SEPTIN7/CAST/PLCD3/RPS6KA5/H3-3A/NFKB1/H3C14/ITPR3/CYTH1/MAPK8/MALT1/BCL2/ELMO1/PLCD1/VCL/ITGB1/CD44/IL1R1/ACTR3/H3C7/GSK3B/MYL12A/H3C8/MAPK1/ACTB/PXN/PFN2/ITPR1/FNBP1	4.77764135345429
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	43/587	362/9376	1.89731474771052	ITGB6/EFNA5/LAMB3/ITGA2/COL4A6/LAMA3/AREG/ITGA3/YWHAZ/ITGB4/MET/NGF/THBS1/JAK1/DDIT4/TNC/NFKB1/IL2RB/LAMA5/COL4A5/THBS3/PPP2R3A/BCL2/EPHA2/COL1A2/IL3RA/PRKCA/PPP2R2B/LAMB1/ITGB1/GSK3B/GNB1/ITGA1/ERBB2/MAPK1/GNG2/PIK3R5/PPP2R5A/CDKN1A/OSMR/FASLG/ITGB7/JAK2	4.49961411635121
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	37/587	300/9376	1.96997160704145	EFNA5/PPP3CA/AREG/RASA2/BRAF/MET/NGF/MAP3K8/RPS6KA5/NFKB1/MAP3K2/FLNA/RAPGEF2/RAC2/DUSP4/PPP3CC/MAPK8/PRKCB/TGFBR2/EPHA2/PRKCA/NFATC3/RAP1B/IL1R1/TGFB1/STK4/ERBB2/CACNG8/RPS6KA3/RELB/MAPK1/RASGRP1/FAS/RPS6KA2/MAP2K4/FASLG/JUND	4.41273007006533
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/587	103/9376	2.7913531036536	CTSG/LAMB3/COL4A6/LAMA3/IL1R2/GNAQ/COL3A1/NFKB1/LAMA5/COL4A5/PRKCB/COL1A2/PRKCA/VCL/LAMB1/IL1R1/TGFB1/GNA14	4.72416045123819
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/587	122/9376	2.61848241963862	PPP3CA/ITK/FYN/MAP3K8/NFKB1/PPP3CC/MAPK8/MALT1/PPP2R3A/NFATC3/PPP2R2B/CARD11/CD247/GSK3B/MAPK1/RASGRP1/CD3E/CBLB/PPP2R5A/GRAP2	4.65005522501893
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	18/587	109/9376	2.6377006392323	PPP3CA/JAK1/NFKB1/IL2RB/PPP3CC/MAPK8/TGFBR2/NFATC3/CD247/RORA/IL1R1/RUNX1/TGFB1/MAPK1/STAT1/CD3E/JAK2/IL21R	4.44440003751671
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	27/587	201/9376	2.14559231101732	H3-3B/H3C4/GZMB/KDM6A/MET/IL1R2/CDK14/H3-3A/NFKB1/SUPT3H/IL2RB/H3C14/NR4A3/PBX3/TGFBR2/DEFA1/IGFBP3/RUNX1/H3C7/H3C8/ETV4/JMJD1C/RUNX2/CDKN1A/ITGB7/ETV6/REL	4.24287306342741
NA	NA	hsa04519	Cadherin signaling	44/587	404/9376	1.73960564710645	VIM/KRT6A/KRT24/KRT5/KRT17/KRT14/GABRP/WNT5A/DSG1/WNT2/KRT16/YWHAZ/FAT1/PKP1/MET/PCDH7/DSC3/CELSR1/MYO1E/NFKB1/KRT81/DSG3/RAC2/CDH10/KRT18/MAPK8/CDH2/WNT7A/KRT15/MYO1B/KRT86/WWTR1/VCL/CDH11/ACTR3/GSK3B/ERBB2/PCDH1/MAPK1/ACTB/FZD6/GJA1/CDH12/AMOTL2	3.92718377796293
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/587	133/9376	2.40191620448054	GZMB/PPP3CA/FYN/BRAF/PRF1/KLRD1/KLRC1/RAC2/CD48/PPP3CC/PRKCB/PRKCA/HCST/CD247/KLRC4-KLRK1/MAPK1/FAS/SH2D1B/FCER1G/FASLG	4.20800605683746
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/587	115/9376	2.50008147544626	AKAP13/PDE4D/BRAF/PDE4A/GNAQ/PTHLH/OXSR1/ITPR3/PRKCB/BCL2/PRKCA/STK39/MAPK1/ADCY3/RUNX2/CDKN1A/ITPR1/JUND	4.18282584351989
Organismal Systems	Immune system	hsa04611	Platelet activation	19/587	126/9376	2.40858819393743	ITGA2/FYN/MYLK/GNAQ/COL3A1/ITPR3/COL1A2/RAP1B/ITGB1/MYL12A/MAPK1/RASGRP1/PIK3R5/ACTB/GP1BB/ADCY3/STIM1/FCER1G/ITPR1	4.11370748410407
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/587	333/9376	1.77474919553284	ITGB6/WNT5A/LAMB3/ITGA2/COL4A6/LAMA3/WNT2/ITGA3/PATJ/ITGB4/THBS1/LLGL2/JAK1/TNC/NFKB1/LAMA5/COL4A5/THBS3/PPP2R3A/WNT7A/TRAF3/COL1A2/PPP2R2B/LAMB1/ITGB1/ATP6V0E1/GSK3B/ITGA1/MAPK1/STAT1/FAS/PPP2R5A/FZD6/CDKN1A/PXN/FASLG/ITGB7	3.72016276737706
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	21/587	154/9376	2.17810128542667	PPP3CA/CAMK1D/MYLK/GNAQ/ITPR3/PPP3CC/CAMK2D/PRKCB/CALM1/PRKCA/NFATC3/CAMK4/MYL6/CACNG8/MAPK1/PPP1R12B/PIK3R5/ACTB/ADCY3/CDKN1A/ITPR1	3.80947728140755
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/587	125/9376	2.30007495741056	SGMS2/MS4A2/FYN/PRKCE/GNAQ/NFKB1/RAC2/MAPK8/PRKCB/PPP2R3A/BCL2/PRKCA/PPP2R2B/FCER1A/MAPK1/FCER1G/PPP2R5A/GAB2	3.78149922235126
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/587	115/9376	2.36118806014369	SLC18A3/FYN/GNAQ/ITPR3/CAMK2D/PRKCB/BCL2/PRKCA/CAMK4/GNB1/MAPK1/GNG2/PIK3R5/KCNQ5/ADCY3/ITPR1/JAK2	3.79553556860366
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/587	137/9376	2.21519790099355	GZMB/CTSW/CAPN2/NGF/PRF1/NFKB1/EIF2AK3/TUBA4A/ITPR3/MAPK8/BCL2/IL3RA/NOL3/MAPK1/FAS/CSF2RB/ACTB/FASLG/ITPR1	3.70279584147555
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	24/587	193/9376	1.98624780432691	ITK/XCL1/XCL2/BRAF/GNAQ/NFKB1/RAC2/PRKCB/ELMO1/CCR3/RAP1B/GSK3B/GNB1/MAPK1/DOCK2/STAT1/GNG2/PIK3R5/ADCY3/GRK5/PXN/JAK2/CCL27/CXCR4	3.57772839896608
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/587	99/9376	2.42011253936297	PLA2G6/PRKCE/NGF/GNAQ/PRKCH/ITPR3/CAMK2D/MAPK8/PRKCB/TRPV3/CALM1/PRKCA/IL1R1/ADCY3/ITPR1	3.67089141093829
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/587	142/9376	2.13719797490222	PPP3CA/FYN/JAK1/FOSL2/NFKB1/ITPR3/PPP3CC/MAPK8/TGFBR2/CAMK4/FOSL1/IL1R1/TGFB1/RELB/MAPK1/STAT1/GAB2/ITPR1/JUND	3.52874496359644
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/587	133/9376	2.16172458403248	TH/PPP3CA/SLC18A2/GNAQ/ITPR3/PPP3CC/CAMK2D/MAPK8/PRKCB/PPP2R3A/CALM1/PRKCA/PPP2R2B/GSK3B/GNB1/GNG2/PPP2R5A/ITPR1	3.48704442559537
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	14/587	93/9376	2.40449891007675	STAT4/PPP3CA/JAK1/NFKB1/IL2RB/PPP3CC/MAPK8/RUNX3/NFATC3/CD247/MAPK1/STAT1/CD3E/JAK2	3.5176583946949
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/587	93/9376	2.40449891007675	LAMB3/ITGA2/COL4A6/LAMA3/ITGA3/NFKB1/LAMA5/COL4A5/TRAF3/BCL2/LAMB1/ITGB1/CDKN2B/CDKN1A	3.5176583946949
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/587	214/9376	1.86597462147145	PPP3CA/GNAQ/NFKB1/APOBEC3B/RAC2/ITPR3/PPP3CC/MAPK8/PRKCB/BCL2/CALM1/PRKCA/NFATC3/CD247/GNB1/MAPK1/GNG2/FAS/APOBEC3H/CD3E/PXN/FASLG/ITPR1/APOBEC3G/CXCR4	3.31170668076205
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/587	116/9376	2.2031369323856	ITK/RHOH/CD99/RAC2/PRKCB/PRKCA/VCL/RAP1B/ITGB1/RASSF5/MSN/MYL12A/ACTB/EZR/PXN/CXCR4	3.36956250026184
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/587	163/9376	1.95984573739823	STAT4/YWHAZ/BRAF/JAK1/NFKB1/MAPK8/PRKCB/TGFBR2/TRAF3/BCL2/PRKCA/NFATC3/TGFB1/MAPK1/STAT1/FAS/MAP2K4/CDKN1A/FASLG/JAK2	3.19469692526294
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/587	98/9376	2.28182039425651	CAMK1D/PRKCE/GNAQ/LDLR/ITPR3/CAMK2D/PRKCB/CALM1/PRKCA/CAMK4/ATP2B4/ADCY3/PRKD1/ITPR1	3.29646134467396
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/587	120/9376	2.12969903463941	BRAF/NGF/RPS6KA5/NFKB1/ARHGDIB/CAMK2D/MAPK8/BCL2/CALM1/CAMK4/RAP1B/GSK3B/RPS6KA3/MAPK1/RPS6KA2/FASLG	3.21867157224119
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/587	69/9376	2.54637928054712	MS4A2/FYN/RAC2/MAPK8/PRKCA/FCER1A/MAPK1/ALOX5AP/MAP2K4/FCER1G/GAB2	3.33173665667869
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	21/587	178/9376	1.88442470761633	WNT5A/PPP3CA/DKK1/WNT2/GPC4/CELSR1/ROR2/RAC2/PPP3CC/CAMK2D/MAPK8/PRKCB/WNT7A/PRKCA/NFATC3/ROR1/FOSL1/GSK3B/MCC/PPARD/FZD6	3.07864151740278
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	26/587	238/9376	1.74492147796086	PLAAT2/EFNA5/RASA2/PLA2G6/ETS1/MET/NGF/NFKB1/RAC2/MAPK8/PRKCB/EPHA2/CALM1/PRKCA/RALGAPA1/RAP1B/RASSF5/GNB1/STK4/MAPK1/GNG2/RASGRP1/RIN1/GAB2/FASLG/REL	3.00821141228569
Human Diseases	Substance dependence	hsa05034	Alcoholism	22/587	191/9376	1.83979235976703	H3-3B/TH/H3C4/BRAF/SLC18A2/H2AC17/H2AC13/H3-3A/H2AZ2/H2AC14/H3C14/CALM1/H2BC9/CAMK4/H2AC20/H3C7/GNB1/H3C8/H2AC12/MAPK1/GNG2/H2AC16	3.03028850995339
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/587	112/9376	2.13920661961548	LAMB3/LAMA3/JAK1/NFKB1/LDLR/LAMA5/MAPK8/BCL2/LAMB1/ITGB1/TGFB1/MAPK1/STAT1/PIK3R5/JAK2	3.13434786282626
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/587	227/9376	1.75911263874401	AKAP13/PPP3CA/GNAQ/JAK1/NFKB1/RAC2/ITPR3/PPP3CC/PRKCB/CALM1/CCR3/PRKCA/NFATC3/IL1R1/GSK3B/GNB1/MAPK1/GNG2/FAS/ADCY3/CDKN1A/PXN/FASLG/ITPR1/CXCR4	2.99203929983319
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	19/587	157/9376	1.93300708558036	PPP3CA/CAPN2/ETS1/NFKB1/ITPR3/PPP3CC/TGFBR2/CALM1/IGFBP3/NFATC3/ZFP36L2/CDKN2B/RASSF5/TGFB1/HIPK2/MAPK1/MCU/CDKN1A/ITPR1	3.04668684410558
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/587	170/9376	1.87914620703477	RAB8B/MYH14/PATJ/PRKCE/LLGL2/TUBA4A/RAPGEF2/MAPK8/PPP2R2B/ITGB1/MSN/RUNX1/ACTR3/MYL6/MYL12A/ERBB2/MYH9/ACTB/EZR/AMOTL2	2.98940694217827
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	27/587	254/9376	1.69788997840347	AVPR1A/PPP3CA/CAMK1D/MYLK/MET/NGF/GNAQ/PLCD3/ADRA1B/ITPR3/PPP3CC/CAMK2D/PRKCB/CALM1/PLCD1/PRKCA/NFATC3/CAMK4/MST1R/ATP2B4/ERBB2/MCU/GNA14/ADCY3/STIM1/ITPR1/CXCR4	2.91402815066955
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/587	196/9376	1.79285888120154	PPP3CA/JAK1/NFKB1/ITPR3/PPP3CC/MAPK8/TRAF3/CALM1/CCR3/NFATC3/CLEC2B/GSK3B/GNB1/MAPK1/STAT1/GNG2/FAS/PIK3R5/MAP2K4/CDKN1A/ITPR1/JAK2	2.89892878730663
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/587	105/9376	2.12969903463941	PPP3CA/NFKB1/ITPR3/PPP3CC/MAPK8/MALT1/CALM1/NFATC3/RELB/MAPK1/STAT1/CBLB/FCER1G/ITPR1	3.0083549272202
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/587	200/9376	1.75700170357751	MYH14/MYO6/FYN/MYO5B/MYO1E/NFKB1/BAIAP2L1/TUBA4A/CYTH1/MAPK8/MYO1B/ITGB1/IL1R1/ACTR3/TMED10/ABI1/MAPK1/MYH9/FAS/ACTB/EZR/FASLG	2.79653403228756
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/587	86/9376	2.2287548036924	AREG/BRAF/CAMK2D/MAPK8/PRKCB/PRKCA/GSK3B/ERBB2/MAPK1/CBLB/MAP2K4/CDKN1A	2.95829550674552
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/587	86/9376	2.2287548036924	ITGB6/ITGA2/ITGA3/ITGB4/CDH2/ITGB1/ITGA1/SGCE/CACNG8/ACTB/GJA1/ITGB7	2.95829550674552
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/587	76/9376	2.31184434681252	MYLK/GNAQ/ITPR3/CAMK2D/PRKCB/CALM1/PRKCA/ACTB/ADCY3/EZR/ITPR1	2.96744437326634
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/587	77/9376	2.28182039425651	BRAF/JAK1/NFKB1/RAC2/MAPK8/TGFBR2/TGFB1/ERBB2/MAPK1/STAT1/CDKN1A	2.91869942405707
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/587	170/9376	1.78518889668303	WNT5A/WNT2/BRAF/MET/GSTO2/PRKCB/TGFBR2/ARID2/WNT7A/PRKCA/TGFB1/GSK3B/ARID1B/NFE2L2/DPF3/MAPK1/ACTB/FZD6/CDKN1A	2.669918973526
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/587	101/9376	2.05589758294398	WNT5A/EDN1/WNT2/GNAQ/CAMK2D/PRKCB/WNT7A/CALM1/PRKCA/GSK3B/MAPK1/ADCY3/FZD6	2.75715054575098
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/587	195/9376	1.72014152797798	H3-3B/CTSG/H3C4/H2AC17/H2AC13/H3-3A/NFKB1/H2AZ2/H2AC14/H3C14/RAC2/PRKCB/H2BC9/PRKCA/H2AC20/H3C7/H3C8/H2AC12/MAPK1/ACTB/H2AC16	2.62618383884996
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/587	80/9376	2.19625212947189	BRAF/MET/JAK1/AXL/PRKCB/BCL2/PRKCA/GSK3B/ERBB2/MAPK1/JAK2	2.77686403980798
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/587	102/9376	2.03574172428767	KCNMA1/RAB27B/CPA3/GNAQ/RAB11A/ITPR3/PRKCB/PRSS3/PRKCA/RAP1B/ATP2B4/ADCY3/ITPR1	2.71802200600792
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/587	91/9376	2.10629574854447	IFITM1/PPP3CA/NFKB1/RAC2/PPP3CC/PRKCB/MALT1/DAPP1/NFATC3/CARD11/GSK3B/MAPK1	2.74053871809426
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/587	50/9376	2.55563884156729	SDC1/MET/THBS1/KLRB1/THBS3/HBB/KLRC4-KLRK1/TGFB1	2.85023737969838
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/587	103/9376	2.0159772415276	GNAQ/NFKB1/MAPK8/TGFBR2/PPP2R2B/CD247/TGFB1/MAPK1/FAS/CD3E/GNA14/MAP2K4/FASLG	2.67933747623153
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/587	138/9376	1.85191220403427	GNAQ/NFKB1/RAC2/MAPK8/ELMO1/NFATC3/ITGB1/ACTR3/GSK3B/RPS6KA3/MAPK1/RPS6KA2/ACTB/MAP2K4/PXN/ARHGEF7	2.60543570590305
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/587	41/9376	2.72705364191632	BRAF/THBS1/RPS6KA5/ERBB2/MAPK1/DAPK2/CDKN1A	2.86401673081989
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/587	93/9376	2.06099906578007	GNAQ/MAP3K2/ITPR3/CAMK2D/MAPK8/PRKCB/CALM1/PRKCA/MAPK1/MAP2K4/ADCY3/ITPR1	2.65734080939996
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/587	212/9376	1.65754877695992	EFNA5/SIPA1L1/SKAP1/BRAF/MET/NGF/THBS1/GNAQ/RAPGEF2/RAC2/PRKCB/EPHA2/CALM1/PRKCA/RAP1B/ITGB1/RASSF5/MAPK1/ACTB/ADCY3/PRKD1/PFN2	2.50258202629142
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/587	116/9376	1.9277448158374	PPP3CA/SLC38A1/SLC1A6/GNAQ/ITPR3/PPP3CC/PRKCB/SLC38A2/PRKCA/GNB1/MAPK1/GNG2/ADCY3/ITPR1	2.59828624415972
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/587	130/9376	1.84300877997641	COL4A6/EDN1/COL3A1/NFKB1/COL4A5/MAPK8/TGFBR2/COL1A2/PRKCA/TGFB1/GNB1/MAPK1/GNG2/MAP2K4/ADCY3	2.50127697915401
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/587	142/9376	1.79974566307556	SDC1/EDN1/IL1R2/CAV2/GPC1/NFKB1/GSTO2/RAC2/MAPK8/BMPR1A/BCL2/CALM1/IL1R1/NFE2L2/ACTB/MAP2K4	2.48162460980341
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/587	97/9376	1.97600941358296	GNAQ/RPS6KA5/ITPR3/CAMK2D/PRKCB/CALM1/PRKCA/GNB1/MAPK1/GNG2/ADCY3/ITPR1	2.49703277528138
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/587	168/9376	1.71136529569238	TNFAIP3/STAT4/CAPN2/H2AC17/H2AC13/JAK1/H2AZ2/H2AC14/CAMK2D/MAPK8/BCL2/H2AC20/H2AC12/STAT1/FAS/H2AC16/FASLG/JAK2	2.40436067539005
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/587	17/9376	3.75829241406955	MYH14/PCDH7/PCDH1/MYH9	2.94160935930995
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/587	157/9376	1.72953265551927	WNT5A/SNAI2/AREG/WNT2/PATJ/YWHAZ/LLGL2/CCN2/TGFBR2/BMPR1A/WNT7A/WWTR1/PPP2R2B/TGFB1/GSK3B/ACTB/FZD6	2.38225151584288
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/587	99/9376	1.93609003149037	ITGB6/ITGA2/EDN1/ITGA3/ITGB4/ITGB1/TGFB1/ITGA1/SGCE/CACNG8/ACTB/ITGB7	2.41972714219143
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/587	36/9376	2.66212379329926	B3GNT3/GALNT3/B4GALT5/GALNT13/GALNT5/ST6GALNAC2	2.58211829817309
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/587	224/9376	1.56875152105135	PPP3CA/ETS1/IL1R2/JAK1/TSPO/NFKB1/IL2RB/PPP3CC/MAPK8/TGFBR2/KAT2B/NFATC3/FOSL1/CDKN2B/IL1R1/TGFB1/RELB/MAPK1/CD3E/MAP2K4/ADCY3/CDKN1A	2.22650426385086
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/587	90/9376	1.95222411508613	PPP3CA/JAK1/NFKB1/PPP3CC/NFATC3/CD247/MAPK1/STAT1/RASGRP1/CD3E/JAK2	2.34574634027655
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/587	37/9376	2.59017450158847	GNAQ/PRKCB/PRKCA/HBB/FAS/FASLG	2.50455409437699
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/587	91/9376	1.93077110283243	GABRP/PDE4D/PDE4A/PDE10A/PRKCB/PRKCA/GNB1/PDE7A/GNG2/ADCY3/GRK5	2.30572543404567
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/587	103/9376	1.8609020691024	COL7A1/COL12A1/COL4A6/COL17A1/CPA3/COL3A1/COL5A1/COL4A5/SLC38A2/COL1A2/PRSS3/COL5A2	2.2703728812302
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/587	139/9376	1.72367727623693	KRT24/KRT17/KRT14/KRT16/ESR2/NCOA1/GNAQ/ITPR3/KRT18/BCL2/KRT15/CALM1/MAPK1/ADCY3/ITPR1	2.22137469738131
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/587	69/9376	2.08340122953855	KCNMA1/PPP3CA/EDN1/GNAQ/EDN2/ITPR3/PPP3CC/CALM1/ITPR1	2.3342317345763
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/587	69/9376	2.08340122953855	TH/PPP3CA/SLC18A2/PPP3CC/CAMK2D/PRKCB/CALM1/PRKCA/CAMK4	2.3342317345763
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/587	38/9376	2.52201201470456	SFN/NR3C2/SCNN1A/PRKCB/PRKCA/MAPK1	2.42950557988114
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/587	216/9376	1.55290554609124	PPP3CA/NFKB1/EIF2AK3/LDLR/PPP3CC/CAMK2D/MAPK8/TRAF3/BCL2/CALM1/PRKCA/NFATC3/RAP1B/GSK3B/NFE2L2/MAPK1/FAS/MAP2K4/FASLG/ITPR1/JAK2	2.12454063295887
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/587	105/9376	1.82545631540521	ITGB6/ITGA2/ITGA3/ITGB4/ITGB1/TGFB1/ITGA1/SGCE/CACNG8/ACTB/ADCY3/ITGB7	2.19816561536403
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/587	154/9376	1.65950574127746	GNAQ/RPS6KA5/ADRA1B/CAMK2D/PPP2R3A/CREM/BCL2/CALM1/PRKCA/PPP2R2B/ATP2B4/CACNG8/MAPK1/PIK3R5/ADCY3/PPP2R5A	2.1325603913966
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	16/587	155/9376	1.64879925262406	WNT5A/WNT2/BRAF/GNAQ/LDLR/ITPR3/CAMK2D/WNT7A/RAP1B/CDKN2B/GSK3B/MAPK1/ADCY3/FZD6/CDKN1A/ITPR1	2.10485476840784
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/587	298/9376	1.44719481380698	XCL1/XCL2/NGF/IL1R2/CLCF1/IL1RL2/IL2RB/RELL1/TGFBR2/BMPR1A/IL3RA/CCR3/INHBA/EDA2R/IL1R1/IL18R1/TGFB1/FAS/CSF2RB/IL17RC/IL1RL1/OSMR/IL32/FASLG/IL21R/CCL27/CXCR4	2.02742481469294
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/587	143/9376	1.67546252725128	H3-3B/CTSG/H3C4/H2AC17/H2AC13/H3-3A/H2AZ2/H2AC14/H3C14/H2BC9/H2AC20/H3C7/H3C8/H2AC12/H2AC16	2.103453027338
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/587	73/9376	1.96924225805699	BRAF/MET/PRKCB/PRKCA/RASSF5/STK4/ERBB2/MAPK1/CDKN1A	2.14841025577342
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/587	122/9376	1.7020135727651	NCOA1/PLCD3/PRKCB/KAT2B/PLCD1/PRKCA/PFKP/MED13L/GSK3B/MAPK1/STAT1/ACTB/THRB	2.01695232673547
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/587	122/9376	1.7020135727651	GNAQ/ITPR3/MAPK8/PRKCB/IGFBP3/PRKCA/GSK3B/MAPK1/STAT1/MAP2K4/ADCY3/ITPR1/JAK2	2.01695232673547
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/587	110/9376	1.74248102834133	EDN1/TIMP1/NFKB1/EGLN3/CAMK2D/PRKCB/BCL2/PRKCA/PFKP/ERBB2/MAPK1/CDKN1A	2.02427966496894
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/587	110/9376	1.74248102834133	EMP3/DCN/THSD4/THBS1/SMURF2/ID4/TGFBR2/BMPR1A/INHBA/CDKN2B/TGFB1/MAPK1	2.02427966496894
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/587	98/9376	1.79285888120154	BPNT2/PLCD3/ITPR3/PRKCB/PIP4K2A/CALM1/PLCD1/PRKCA/MTMR3/INPP5A/ITPR1	2.03899755798339
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/587	98/9376	1.79285888120154	PLPP2/PLA2G6/PRKCE/PLPP1/RAC2/PRKCB/PRKCA/GSN/ACTR3/MAPK1/GAB2	2.03899755798339
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/587	173/9376	1.5695758781302	TPSB2/TPSAB1/JAK1/NFKB1/RAB11A/PRKCB/TRAF3/PRSS3/PRKCA/MAPK1/STAT1/DNAJC3/FAS/ACTB/FASLG/NUP98/JAK2	1.95409145459743
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/587	87/9376	1.83594744365466	AREG/BRAF/RAC2/MAPK8/TGFBR2/BCL2/TGFB1/GSK3B/MAPK1/CDKN1A	2.02436619080095
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/587	136/9376	1.64425293115543	TNFAIP3/JAK1/NFKB1/IL2RB/MAPK8/TRAF3/BCL2/MSN/GSK3B/STAT1/FAS/CD3E/CBLB/FASLG	1.95580174058949
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/587	76/9376	1.89150901102842	CAMK1D/BRAF/CAMK2D/PRKCB/CALM1/PRKCA/CAMK4/MAPK1/CDKN1A	2.01662903447387
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/587	100/9376	1.75700170357751	CD9/ITGA2/ITGA3/IL1R2/IL3RA/CD44/IL1R1/CD55/ITGA1/CD3E/GP1BB	1.96676034614622
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/587	89/9376	1.79469019772984	GNAQ/MAP3K2/TUBA4A/ITPR3/PRKCB/PRKCA/MAPK1/ADCY3/GJA1/ITPR1	1.9466599471565
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/587	140/9376	1.59727427597956	MYLK/PRKCE/GNAQ/ITPR3/CCN2/CALM1/CAMK4/NRF1/GNB1/MAPK1/GNG2/PIK3R5/ADCY3/ITPR1	1.84005507783253
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/587	166/9376	1.53954147082367	KCNMA1/PPP3CA/MYLK/PRKCE/GNAQ/ADRA1B/ITPR3/PPP3CC/CALM1/NFATC3/KCNMB4/ATP2B4/MAPK1/PIK3R5/ADCY3/ITPR1	1.81252504822766
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/587	34/9376	2.34893275879347	BHLHE40/CRY1/NPAS2/NFIL3/RORA	2.03631417883382
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/587	45/9376	2.12969903463941	GZMB/PRF1/KLRD1/KLRC1/FAS/FASLG	1.96308848863019
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/587	194/9376	1.48200706018722	MYH14/KLC3/MYO6/MYO16/MYO5B/TNNT1/MYO1E/MYH15/TUBA4A/MYO1B/MYO9B/MYL6/MYL12A/MYH9/KIF21A/ACTB/DNAH5/DNALI1	1.75315605881591
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/587	105/9376	1.67333495578811	TNFAIP3/NFKB1/CARD10/PRKCB/MALT1/TRAF3/BCL2/CARD11/EDA2R/IL1R1/RELB	1.79307095943595
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/587	93/9376	1.71749922148339	KCNMA1/GNAQ/ADRA1B/ITPR3/PRKCB/CALM1/PRKCA/ATP2B4/ADCY3/ITPR1	1.79702322410502
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	22/587	250/9376	1.40560136286201	AGAP1/CAV2/SH3KBP1/VPS37B/RAB11FIP1/SMURF2/LDLR/IL2RB/RAB11A/CYTH1/TGFBR2/EHD2/SMAP1/ACTR3/RAB11FIP5/ARAP2/GBF1/CBLB/STAM/GRK5/CXCR4/PIP5KL1	1.67982536337698
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/587	144/9376	1.55290554609124	HAND1/WNT5A/WNT2/JARID2/JAK1/ID4/BMPR1A/WNT7A/INHBA/GSK3B/MAPK1/FZD6/JAK2/KAT6A	1.7279025717246
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/587	119/9376	1.61069674888695	TNFAIP3/EDN1/MAP3K8/RPS6KA5/NFKB1/MAPK8/TRAF3/IL18R1/RHBDF1/MAPK1/FAS/MAP2K4	1.73260240701202
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/587	94/9376	1.69922795316974	TNFAIP3/NFKB1/S100A9/MAPK8/TRAF3/FOSL1/GSK3B/MAPK1/IL17RC/JUND	1.7607467003432
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/587	70/9376	1.82545631540521	ETS1/BRAF/MET/EGLN3/RAP1B/TGFB1/MAPK1/CDKN1A	1.79141640543032
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/587	71/9376	1.79974566307556	TH/ESR2/NFKB1/MAPK8/GSK3B/MAPK1/STAT1/JAK2	1.74806604030776
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/587	60/9376	1.86348665530948	PPP3CA/RAC2/PPP3CC/PRKCB/PRKCA/MAPK1/PXN	1.73400949818397
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/587	60/9376	1.86348665530948	BRAF/GNAQ/ITPR3/PRKCB/PRKCA/MAPK1/ITPR1	1.73400949818397
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	14/587	150/9376	1.49078932424759	WNT5A/WNT2/BRAF/MET/TGFBR2/WNT7A/BCL2/CDKN2B/TGFB1/GSK3B/ERBB2/MAPK1/FZD6/CDKN1A	1.56591782685871
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/587	86/9376	1.6715661027693	KCNMA1/RIMS2/GNAQ/ITPR3/CAMK2D/PRKCB/PRKCA/KCNMB4/ADCY3	1.61683273044795
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/587	138/9376	1.50467866577784	PPP3CA/YWHAZ/ITPR3/PPP3CC/CAMK2D/CALM1/RPS6KA3/MAPK1/RPS6KA2/ADCY3/PPP2R5A/SPDYA/ITPR1	1.54347808330283
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/587	75/9376	1.70375922771153	SFN/SERPINB5/THBS1/COP1/BCL2/IGFBP3/FAS/CDKN1A	1.58133858693865
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/587	75/9376	1.70375922771153	GNAQ/GPX1/TG/ITPR3/PRKCB/PRKCA/ADCY3/ITPR1	1.58133858693865
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/587	248/9376	1.35253063691817	AHNAK2/AHNAK/KLC3/MYO6/RHOH/S100A10/NFKB1/EXOC4/FLNA/TUBA4A/CYTH1/MAPK8/BCL2/ELMO1/ACTR3/MYL12A/ABI1/MAPK1/ACTB/MAP2K4/PFN2	1.45401821435425
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/587	51/9376	1.87914620703477	PRKCA/ATP6V0E1/SEC61G/KDELR3/ACTB/ADCY3	1.62688453617468
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/587	77/9376	1.65950574127746	BRAF/NFKB1/TGFBR2/RUNX1/TGFB1/MAPK1/CDKN1A/GAB2	1.50169168461807
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	37/587	480/9376	1.23123225440091	WNT5A/COX7A1/MT-ND3/OPTN/PPP3CA/KLC3/CAPN2/DKK1/WNT2/BRAF/ATXN1/GNAQ/ATP5F1E/GPX1/NFKB1/EIF2AK3/TUBA4A/ITPR3/PPP3CC/CAMK2D/MT-ND2/MAPK8/PRKCB/WNT7A/BCL2/CALM1/PRKCA/GSK3B/MAPK1/MCU/FAS/DNAH5/COX6B2/FZD6/FASLG/DNALI1/ITPR1	1.34402269281976
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/587	156/9376	1.43345127331499	YWHAZ/BRAF/JAK1/NFKB1/LDLR/PIAS1/TRAF3/PPP2R2B/GSK3B/MAPK1/STAT1/FAS/CDKN1A/FASLG	1.41082152894013
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/587	65/9376	1.72014152797798	ESR2/GNAQ/ITPR3/PRKCB/PRKCA/MAPK1/ITPR1	1.50560596753718
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/587	78/9376	1.6382300266457	MET/CAV2/ELMO1/VCL/ITGB1/ACTR3/ACTB/PXN	1.46273185513571
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/587	78/9376	1.6382300266457	JAK1/NFKB1/PRKCB/ITGB1/TGFB1/MAPK1/STAT1/JAK2	1.46273185513571
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/587	117/9376	1.50171085775856	H2AC17/H2AC13/H2AZ2/H2AC14/ARID2/H2AC20/ARID1B/DPF3/H2AC12/ACTB/H2AC16	1.41123502100507
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/587	66/9376	1.69407877755408	STAT4/NFKB1/RORA/IL18R1/TGFB1/STAT1/IL21R	1.46231471183763
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/587	187/9376	1.36665178693438	TNFAIP3/NEK7/ANTXR2/JAK1/NFKB1/ITPR3/MAPK8/TRAF3/BCL2/DEFA1/NAMPT/MAPK1/MCU/STAT1/GBP2/ITPR1	1.3088064904682
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/587	174/9376	1.376960582741	SSR4/FBXO2/MARCHF6/CRYAB/CAPN2/DNAJC1/DAD1/EIF2AK3/MAPK8/BCL2/NFE2L2/SEC61G/SELENOS/DNAJC3/SEC31A	1.29707296206633
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/587	32/9376	1.99659284497445	BOK/BIRC6/MAPK8/BCL2	1.45935616024055
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/587	149/9376	1.3935950058882	AVPR1A/PLPP2/MS4A2/FYN/PLPP1/CYTH1/PRKCA/FCER1A/MAPK1/PIK3R5/ADCY3/FCER1G/GAB2	1.25154770955123
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/587	149/9376	1.3935950058882	GABRP/MT-ND3/GNAQ/ITPR3/MT-ND2/MAPK8/PRKCB/PRKCA/GNB1/MAPK1/GNG2/ADCY3/ITPR1	1.25154770955123
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/587	21/9376	2.28182039425651	ENPP1/ENPP3/DPYD	1.51967208215351
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/587	205/9376	1.32456891178793	CMA1/COX7A1/MT-ND3/COL3A1/ATP5F1E/NFKB1/RAC2/CAMK2D/MT-ND2/MAPK8/PRKCB/TGFBR2/COL1A2/PRKCA/TGFB1/GSK3B/COX6B2	1.21425656388417
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/587	33/9376	1.93609003149037	VTI1A/STX11/STX3/STX8	1.39208698299992
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	15/587	181/9376	1.32370796351897	PPP3CA/JAK1/NFKB1/PPP3CC/CAMK2D/MAPK8/MALT1/BCL2/CALM1/TGFB1/ITGAX/MAPK1/STAT1/FCER1G/JAK2	1.13645373634873
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/587	168/9376	1.33106189664963	STAT4/CLCF1/JAK1/PIAS1/IL2RB/BCL2/IL3RA/STAT1/CSF2RB/STAM/CDKN1A/OSMR/JAK2/IL21R	1.11896406845328
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/587	12/9376	2.66212379329926	NECTIN4/NCAM1	1.48887502027309
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/587	73/9376	1.53163286737766	MAP1B/ELL2/APOBEC3B/KAT2B/APOBEC3H/APOBEC3G/CXCR4	1.17841075859616
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/587	23/9376	2.08340122953855	CMA1/CTSG/CPA3	1.34435117639157
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	29/587	388/9376	1.19383902070637	WNT5A/COX7A1/MT-ND3/PPP3CA/KLC3/CAPN2/DKK1/WNT2/BRAF/GNAQ/ATP5F1E/NFKB1/EIF2AK3/TUBA4A/ITPR3/PPP3CC/MT-ND2/MAPK8/WNT7A/CALM1/RTN4/SLC39A11/GSK3B/MAPK1/MCU/FAS/COX6B2/FZD6/ITPR1	1.0077678389819
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/587	115/9376	1.3889341530257	BRAF/SLC18A2/GNAQ/ITPR3/PRKCB/PRKCA/GNB1/MAPK1/GNG2/ITPR1	1.08450364419003
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/587	75/9376	1.49078932424759	GSTO2/BCL2/ERBB2/MAPK1/FAS/CDKN1A/FASLG	1.10279775515552
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/587	158/9376	1.31421301188191	WNT5A/WNT2/BRAF/DDIT4/PRKCB/WNT7A/PRKCA/GSK3B/RPS6KA3/MAPK1/RPS6KA2/FZD6/SLC7A5	1.02936480171664
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/587	89/9376	1.43575215818387	GABRP/SLC38A1/PRKCB/SLC38A2/PRKCA/GNB1/GNG2/ADCY3	1.0674112700103
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/587	63/9376	1.52121359617101	WNT5A/WNT2/WNT7A/GSK3B/FZD6/CDKN1A	1.07269477658226
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/587	104/9376	1.38225658498231	PLAAT2/SGMS2/PLPP2/PLA2G6/PLPP1/TAFAZZIN/GPAT3/ETNK2/LPGAT1	1.01302436337194
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/587	38/9376	1.68134134313638	NT5E/ENPP1/ENPP3/NAMPT	1.08758838889642
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/587	51/9376	1.56595517252898	PLAAT2/PLPP2/PLA2G6/PLPP1/PAFAH1B1	1.04731580593517
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/587	205/9376	1.24665309344746	VIM/TNFAIP3/JAK1/NFKB1/MAPK8/TRAF3/BCL2/RUNX3/CD247/CD44/RELB/STAT1/FAS/CD3E/MAP2K4/CDKN1A	0.922762861270604
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/587	26/9376	1.84300877997641	BTD/CUBN/LMBRD1	1.1123665558231
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/587	39/9376	1.6382300266457	GZMB/PRF1/FAS/FASLG	1.03214523793282
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/587	107/9376	1.34350172745944	PPP3CA/SIK1/GNAQ/ITPR3/PPP3CC/CAMK2D/CALM1/PFKP/ITPR1	0.92350516731883
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/587	53/9376	1.50686252450902	GNAQ/RAB11A/PRKCB/PRKCA/ATP2B4	0.956280349509497
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/587	54/9376	1.47895766294403	GZMB/PRF1/TG/FAS/FASLG	0.912167119208572
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/587	226/9376	1.20148949963064	SOX9/EDN1/PDE4D/BRAF/PDE4A/PDE10A/NFKB1/EDN2/RAC2/CAMK2D/MAPK8/CALM1/CAMK4/RAP1B/ATP2B4/MAPK1/ADCY3	0.792375515806801
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/587	29/9376	1.6523526992892	RGS9/CALM1/GNB1	0.909243694447648
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/587	70/9376	1.36909223655391	FYN/PRF1/RAC2/CD55/SGCE/ACTB	0.801008939346546
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/587	275/9376	1.16165401889422	COX7A1/MT-ND3/PPP3CA/KLC3/FYN/CAV2/ATP5F1E/EIF2AK3/TUBA4A/RAC2/ITPR3/PPP3CC/MT-ND2/MAPK8/NCAM1/GSK3B/MAPK1/MCU/COX6B2/ITPR1	0.703142344035045
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/587	142/9376	1.23732514336445	FBXO2/BIRC6/COP1/FBXW7/HERC1/SMURF2/PIAS1/MID1/CBLB/UBR5/WWP2	0.736424020148378
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/587	157/9376	1.22084658036654	PLA2G6/ATP11B/THBS1/AXL/DUSP4/CAMK2D/ELMO1/NFATC3/TGFB1/MAPK1/PPARD/JAK2	0.721163195186147
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/587	99/9376	1.29072668766025	BRAF/ESR2/MAPK8/BCL2/ERBB2/MAPK1/ADCY3/CDKN1A	0.751508117195614
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/587	99/9376	1.29072668766025	KRT24/KRT17/KRT14/DSG1/KRT16/KRT18/KRT15/DEFA1	0.751508117195614
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/587	71/9376	1.34980924730667	MET/PFKP/SLC16A3/ERBB2/MAPK1/SLC7A5	0.764605166411052
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/587	144/9376	1.22014007192883	SLC1A6/ATXN1/GNAQ/ITPR3/MAPK8/PRKCB/PRKCA/RORA/PUM2/MCU/ITPR1	0.687966686379909
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/587	44/9376	1.45206752361778	GZMB/PRF1/FAS/FASLG	0.776742803736744
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/587	160/9376	1.19795570698467	SDC1/SLITRK6/NECTIN3/ALCAM/CD99/VTCN1/NRXN3/CDH2/NCAM1/PTPRS/ITGB1/ITGB7	0.652667130941013
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/587	205/9376	1.16873727510699	RASA2/YWHAZ/JAK1/NFKB1/TRAF3/KAT2B/CCR3/H2BC9/GSN/CDKN2B/MAPK1/SP100/CDKN1A/PXN/REL	0.63126915865704
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/587	59/9376	1.35362226777929	NT5E/ENPP1/ENPP3/DPYD/UPP1	0.70414568068971
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/587	59/9376	1.35362226777929	BRAF/GSK3B/ERBB2/MAPK1/CDKN1A	0.70414568068971
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/587	148/9376	1.18716331322805	WNT5A/WNT2/BRAF/ESR2/NCOA1/WNT7A/GSK3B/ERBB2/MAPK1/FZD6/CDKN1A	0.593106585186305
Human Diseases	Immune disease	hsa05310	Asthma	3/587	32/9376	1.49744463373083	MS4A2/FCER1A/FCER1G	0.728430767162802
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/587	106/9376	1.20549001960721	BRAF/IL1R2/NFKB1/BCL2/GSK3B/ERBB2/MAPK1/CDKN1A	0.549843069975555
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/587	20/9376	1.59727427597956	CYB5R2/GMDS	0.691000972133686
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/587	78/9376	1.22867251998427	PLCD3/PIP4K2A/PLCD1/MTMR3/INPP5A/PIP5KL1	0.524084680147521
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/587	49/9376	1.30389736814658	TH/RGS9/SLC18A2/NFKB1	0.551174284731721
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/587	109/9376	1.17231139521435	JAK1/MAP3K8/NFKB1/MAPK8/TRAF3/MAPK1/STAT1/MAP2K4	0.467619510556108
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/587	109/9376	1.17231139521435	PRKCE/SLC27A6/NFKB1/MAPK8/PRKCB/GSK3B/RPS6KA3/RPS6KA2	0.467619510556108
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/587	21/9376	1.52121359617101	CHST11/CSGALNACT2	0.617928810064951
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	8/587	110/9376	1.16165401889422	BRAF/MAPK8/STK10/RPS6KA3/MAPK1/RPS6KA2/ADCY3/SPDYA	0.440729029722285
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/587	65/9376	1.22867251998427	PLPP2/PLPP1/LIPC/LIPG/GPAT3	0.478087566574294
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/587	65/9376	1.22867251998427	GNAQ/LDLR/ITPR3/ADCY3/ITPR1	0.478087566574294
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/587	158/9376	1.11202639466931	SFN/YWHAZ/STAG1/CCNH/NIPBL/CDKN2B/TGFB1/GSK3B/STAG2/PPP2R5A/CDKN1A	0.366999529539355
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	9/587	128/9376	1.12308347529813	NT5E/ENPP1/ENPP3/PDE4D/ADSS2/PDE4A/PDE10A/PDE7A/ADCY3	0.362339583727191
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/587	37/9376	1.29508725079424	BRAF/MAPK1/CDKN1A	0.464767848708983
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/587	52/9376	1.22867251998427	TSPO/LDLR/LIPC/LIPG	0.427316314173759
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	18/587	268/9376	1.07279615550866	TH/COX7A1/MT-ND3/KLC3/SLC18A2/ATP5F1E/EIF2AK3/TUBA4A/ITPR3/CAMK2D/MT-ND2/MAPK8/CALM1/SLC39A11/NFE2L2/MCU/COX6B2/ITPR1	0.312463495382111
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/587	68/9376	1.17446637939673	BRAF/NFKB1/RUNX1/MAPK1/PPARD	0.373141002609927
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/587	99/9376	1.12938585170272	PLPP2/PLPP1/RAC2/MAPK8/PRKCB/PRKCA/MAPK1	0.33445336094666
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/587	100/9376	1.11809199318569	XCL1/XCL2/IL2RB/CCR3/IL18R1/CCL27/CXCR4	0.306813905830534
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/587	55/9376	1.16165401889422	SGMS2/PLPP2/PLPP1/B4GALT5	0.310721677923202
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/587	133/9376	1.08086229201624	BRAF/MAPK8/TGFBR2/CDKN2B/TGFB1/STK4/MAPK1/CDKN1A/FASLG	0.242717085005938
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/587	71/9376	1.12484103942222	MET/NFKB1/MAPK8/ATP6V0E1/MAP2K4	0.2728747294627
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/587	88/9376	1.08905064271333	CLU/F3/SERPINB2/CD55/ITGAX/F12	0.216896351972543
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/587	10/9376	1.59727427597956	BPNT2	0.488350560344832
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/587	105/9376	1.0648495173197	OPTN/ARIH1/TAX1BP1/SMURF2/EIF2AK3/MAPK8/USP15	0.172692335723609
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/587	26/9376	1.22867251998427	PLAAT2/PLA2G6	0.301737857906313
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/587	169/9376	1.03964597844823	OPTN/BIRC6/TAX1BP1/DDIT4/EIF2AK3/MAPK8/BCL2/MAPK1/MTMR3/DAPK2/ITPR1	0.134405913789558
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/587	27/9376	1.18316613035523	SCD5/ELOVL5	0.246308516894703
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/587	44/9376	1.08905064271333	ARHGDIB/RAB11A/ADCY3	0.15300689008175
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/587	28/9376	1.14091019712825	TH/GCH1	0.192973219648856
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/587	61/9376	1.04739296785545	MT1E/TRPM6/MT1F/ATP2B4	0.0959670954356338
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/587	78/9376	1.02389376665356	PAN3/BTG1/CNOT6L/CNOT2/PFKP	0.0547610926534277
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/587	78/9376	1.02389376665356	NFKB1/MAPK8/CALM1/ITGB1/MAPK1	0.0547610926534277
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/587	144/9376	0.998296422487223	NFKB1/MAPK8/TRAF3/GSK3B/SCD5/FAS/IL17RC/MAP2K4/FASLG	-0.00532390384988764
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/587	79/9376	1.01093308606301	SLC18A3/SLC1A6/SLC18A2/ATP6V0E1/STX3	0.0252185349824392
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	14/587	227/9376	0.985103077696643	COX7A1/MT-ND3/BRAF/MET/ATP5F1E/NFKB1/GSTO2/MT-ND2/MAPK8/NFE2L2/MAPK1/COX6B2/MAP2K4/PRKD1	-0.058716157133087
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/587	30/9376	1.0648495173197	PLAAT2/PLA2G6	0.0919368127328074
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/587	47/9376	1.01953677190184	PRKCE/MAPK8/MAPK1	0.0346991746642688
NA	NA	hsa03272	Virion - Hepatitis viruses	3/587	48/9376	0.998296422487223	CD9/CD63/LDLR	-0.0030578994816968
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/587	31/9376	1.03049953289004	SEC61G/SPCS2	0.0439561188211153
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/587	49/9376	0.977923026109933	GALNT3/GALNT13/GALNT5	-0.0400406899444735
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/587	50/9376	0.958364565587734	TGFB1/ITGB7/CXCR4	-0.0762843330411192
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/587	85/9376	0.939573103517386	NT5E/ENPP1/ENPP3/UPP1/ADSS2	-0.144625035619219
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/587	323/9376	0.939573103517386	VIM/EFNA5/SERPINB5/PRKCE/MET/THBS1/RPS6KA5/DDIT4/TNC/NFKB1/SLC7A1/PRKCB/BCL2/PRKCA/CD44/ERBB2/MAPK1/CDKN1A/EZR	-0.285607920450199
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/587	35/9376	0.912728157702604	PFKP/GMDS	-0.133673843889262
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/587	157/9376	0.915634935274905	COX7A1/NFKB1/EIF2AK3/MAPK8/TGFB1/GSK3B/FAS/COX6B2/FASLG	-0.275489797207895
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/587	17/9376	0.939573103517386	CYP7B1	-0.0644428862366539
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/587	17/9376	0.939573103517386	GGT5	-0.0644428862366539
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/587	17/9376	0.939573103517386	CA5B	-0.0644428862366539
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/587	72/9376	0.887374597766421	RNF125/NFKB1/MAPK8/TRAF3	-0.247914945543791
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/587	36/9376	0.887374597766421	ENPP1/ENPP3	-0.174964171212047
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/587	73/9376	0.875218781358661	BRAF/MET/MAPK1/CDKN1A	-0.276588487169732
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/587	18/9376	0.887374597766421	LMBRD1	-0.12359930927889
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/587	56/9376	0.855682647846191	SMURF2/BCL2/GSK3B	-0.279923632997713
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/587	19/9376	0.840670671568188	HPSE	-0.179654941804539
NA	NA	hsa04082	Neuroactive ligand signaling	11/587	199/9376	0.882915428933424	GABRP/SLC18A3/SLC1A6/SLC18A2/GNAQ/ADRA1B/PRKCB/PRKCA/GNB1/GNG2/ADCY3	-0.431430454187513
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/587	59/9376	0.812173360667571	GPX1/GSTO2/GGT5	-0.374007320395735
NA	NA	hsa04081	Hormone signaling	12/587	219/9376	0.875218781358661	AVPR1A/ESR2/GNAQ/PTHLH/ADRA1B/BMPR1A/GNB1/GNG2/GNA14/ADCY3/THRB/JAK2	-0.482869338986966
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/587	20/9376	0.798637137989779	EBP	-0.232961537096981
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/587	22/9376	0.72603376180889	HDC	-0.332464026778382
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/587	43/9376	0.742918267897468	PLPP2/PLPP1	-0.436646284271393
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/587	155/9376	0.824399626312029	ITGA2/THBS1/TUBA4A/THBS3/ITGB1/ATP6V0E1/SEC61G/ACTB	-0.569688208481173
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/587	63/9376	0.760606798085503	SMYD3/KMT2E/KMT2C	-0.492688293493269
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/587	63/9376	0.760606798085503	PLAAT2/PLA2G6/GGT5	-0.492688293493269
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/587	138/9376	0.810211589264993	BRAF/MAPK8/CALM1/GSK3B/MAPK1/CBLB/INPP5A	-0.580437161897602
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/587	44/9376	0.72603376180889	DAD1/MAN2A1	-0.470729023573245
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/587	83/9376	0.769770735411835	JARID2/L3MBTL4/SFMBT2/SCMH1	-0.544448192636575
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	20/587	368/9376	0.868083845641064	COX7A1/MT-ND3/OPTN/PPP3CA/KLC3/ATP5F1E/GPX1/EIF2AK3/TUBA4A/ITPR3/PPP3CC/MT-ND2/BCL2/MCU/ACTB/DNAH5/COX6B2/NUP98/DNALI1/PFN2	-0.667179447497964
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/587	122/9376	0.785544725891585	RAB2A/PPP2R3A/PPP2R2B/PFKP/SCD5/PPP2R5A	-0.616150571547985
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/587	24/9376	0.665530948324815	EXT1	-0.423978922871047
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/587	180/9376	0.798637137989779	JAK1/NFKB1/TRAF3/BCL2/SP100/STAT1/FAS/FASLG/JAK2	-0.70493829395781
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/587	217/9376	0.8096782044136	ESR2/NFKB1/GSTO2/PRKCB/BCL2/PRKCA/RPS6KA3/MAPK1/RPS6KA2/ADCY3/JAK2	-0.733042779676785
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/587	70/9376	0.684546118276953	NFKB1/MAPK8/JAK2	-0.684602259779107
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/587	28/9376	0.570455098564127	ELOVL5	-0.588251697202472
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/587	28/9376	0.570455098564127	B3GNT3	-0.588251697202472
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/587	28/9376	0.570455098564127	ATP6V0E1	-0.588251697202472
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/587	52/9376	0.614336259992137	LDLR/ADCY3	-0.720683044477578
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/587	29/9376	0.550784233096399	WWTR1	-0.626113150062239
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/587	30/9376	0.532424758659852	NFKB1	-0.662878910719733
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/587	76/9376	0.630503003676141	SLC27A6/SCD5/PPARD	-0.835816981903532
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/587	31/9376	0.515249766445018	PFKP	-0.698625088506412
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/587	31/9376	0.515249766445018	DPYD	-0.698625088506412
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/587	138/9376	0.694467076512851	COX7A1/MT-ND3/ATP5F1E/MT-ND2/ATP6V0E1/COX6B2	-0.934423036097675
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/587	56/9376	0.570455098564127	DAD1/MAN2A1	-0.833162246612078
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/587	32/9376	0.499148211243612	PFKP	-0.733420018992684
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/587	235/9376	0.747660299394686	COX7A1/MT-ND3/ATP5F1E/MT-ND2/ARID1B/RPS6KA3/DPF3/RPS6KA2/ACTB/COX6B2/ADCY3	-1.01241277520264
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/587	57/9376	0.560447114378792	SCD5/ELOVL5	-0.860198862769597
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/587	34/9376	0.469786551758693	POLR1F	-0.800396576792939
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/587	59/9376	0.541448907111714	PLAAT2/ADCY3	-0.913083820938457
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/587	82/9376	0.584368637553496	DPYD/UPP1/GSTO2	-0.976897188130951
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/587	62/9376	0.515249766445018	CRYAB/ADCY3	-0.989647909330296
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/587	62/9376	0.515249766445018	ATXN1/KAT2B	-0.989647909330296
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/587	37/9376	0.431695750264745	ADSS2	-0.895089648403024
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/587	37/9376	0.431695750264745	TH	-0.895089648403024
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/587	37/9376	0.431695750264745	GMDS	-0.895089648403024
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/587	63/9376	0.507071198723669	CCNH/ERCC6	-1.01448265018511
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/587	38/9376	0.420335335784094	CD3E	-0.925287397580653
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/587	87/9376	0.550784233096399	COX7A1/CACNG8/COX6B2	-1.08784017200732
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/587	308/9376	0.72603376180889	COX7A1/MT-ND3/KLC3/GNAQ/ATP5F1E/GPX1/TUBA4A/MT-ND2/MAPK8/NRF1/DNAH5/COX6B2/DNALI1/ITPR1	-1.26343122376912
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/587	66/9376	0.484022507872593	SULT2B1/CYP7B1	-1.08708334286479
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/587	90/9376	0.532424758659852	NFKB1/CAMK4/ADCY3	-1.15184324131339
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/587	41/9376	0.389579091702331	RAD51B	-1.0122764295074
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/587	41/9376	0.389579091702331	GABRP	-1.0122764295074
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/587	44/9376	0.363016880904445	CCNH	-1.09446493722824
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/587	45/9376	0.354949839106568	ABCA12	-1.12090964638483
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/587	46/9376	0.347233538256425	EPRS1	-1.14691407751428
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/587	48/9376	0.332765474162408	PRKCB	-1.19767729699792
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/587	103/9376	0.465225517275599	PPP2R3A/PPP2R2B/PPP2R5A	-1.41030847378179
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/587	50/9376	0.319454855195911	P4HA2	-1.24689301813692
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/587	238/9376	0.604011280832606	JAK1/NFKB1/MAPK8/PRKCB/TRAF3/PRKCA/MAPK1/STAT1/RPS27L	-1.59911859085682
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/587	82/9376	0.389579091702331	KLRD1/KLRC1	-1.43472924031109
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/587	54/9376	0.295791532588807	FANCC	-1.34115363160149
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/587	83/9376	0.384885367705917	NFKB1/ZDHHC1	-1.45462850005577
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/587	56/9376	0.285227549282064	NFKB1	-1.38640086022644
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/587	86/9376	0.371459133948734	SCNN1A/ITPR3	-1.51324708091303
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/587	90/9376	0.354949839106568	LDLR/ADCY3	-1.58904193901213
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/587	95/9376	0.336268268627275	ATP6V0E1/TGFB1	-1.6803198335238
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/587	67/9376	0.238399145668591	PFKP	-1.61677008678324
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/587	370/9376	0.604374050370643	GABRP/CTSG/AVPR1A/EDN1/LYPD6B/NR3C1/GZMA/TSPO/ADRA1B/EDN2/PRSS3/P2RY8/THRB/PTGDR	-2.00657139646284
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/587	68/9376	0.234893275879347	CYP26B1	-1.63637653930316
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/587	70/9376	0.228182039425651	GSTO2	-1.67500972586288
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/587	73/9376	0.218804695339665	GSTO2	-1.73158773293562
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/587	75/9376	0.212969903463941	PFKP	-1.76844723554328
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/587	79/9376	0.202186617212602	GSTO2	-1.8402566839158
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/587	250/9376	0.447236797274276	CTSG/CTSW/CD63/OSBPL3/LITAF/ATP6V0E1/SLC15A4	-2.28930603518723
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/587	154/9376	0.311157326489524	ADSS2/EPRS1/GCH1	-2.22742352263187
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/587	108/9376	0.147895766294403	NUP98	-2.30168848435622
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/587	116/9376	0.1376960582741	PFKP	-2.41500942050405
Genetic Information Processing	Translation	hsa03010	Ribosome	1/587	222/9376	0.0719492917107909	RPS27L	-3.61641028998736
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/587	449/9376	0.249018261288572	CAMK2D/NCALD/CALM1/GNB1/OR2T11/ADCY3/OR2T2	-4.21439013110275