category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	53/273	238/9376	7.64810539600456	RPL39/RPL37/RPS28/RPS27/RPLP1/RPL28/RPL34/RPL12/RPL30/RPS29/RPS21/RPL41/CXCL8/SELP/RPS15A/RPS17/RPS23/RPL37A/RPS11/FAU/RPL36/RPS25/RPS18/RPS12/RPL35A/RPL21/RPS13/RPS19/UBA52/RPL10/RPL22/RPS4X/RPLP2/MMP1/RPL26/RPL7A/RPL17/RPL13/RPS20/RPS9/CCL2/RPL11/RPL27A/RPL32/RPS7/RPL38/RPS27A/RPS24/CFD/RPL24/RPS3A/RPL36A/RPL7	17.9901791415269
Genetic Information Processing	Translation	hsa03010	Ribosome	50/273	222/9376	7.73520773520774	RPL39/RPL37/RPS28/RPS27/RPLP1/RPL28/RPL34/RPL12/RPL30/RPS29/RPS21/RPL41/RPS15A/RPS17/RPS23/RPL37A/RPS11/FAU/RPL36/RPS25/RPS18/RPS12/RPL35A/RPL21/RPS13/RPS19/UBA52/RPL10/RPL22/RPS4X/RPLP2/RPL26/RPL7A/RPL17/RPL13/RPS20/RPS9/RPL11/RPL27A/MRPL33/RPL32/MRPS24/RPS7/RPL38/RPS27A/RPS24/RPL24/RPS3A/RPL36A/RPL7	17.5872006661725
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/273	82/9376	5.86366479049406	HSPA1B/HSPA1A/CTSS/HLA-DPA1/HLA-DPB1/HLA-C/IFI30/HSP90AA1/B2M/HSPA5/HLA-DRB5/CD74/PSME2/HLA-DQA2	7.66026718298768
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/273	95/9376	4.69974937343358	CXCL8/CXCL2/HLA-DPA1/ATP6V0C/MMP1/CCL3L1/HLA-DPB1/CCL2/IL15/TGFB2/CCL5/HLA-DRB5/HLA-DQA2	6.27641153606536
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/273	94/9376	4.38438157587094	S100A8/JUND/S100A9/CXCL8/CXCL2/TNFAIP3/MMP1/FOSL1/PTGS2/CCL2/CEBPB/HSP90AA1	5.71080271420078
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/273	100/9376	3.77787545787546	CXCL8/CCL4L2/CXCL2/CCL3L1/CXCL14/CCL2/CXCL11/XCL1/XCL2/CCL5/CXCR2	4.83623160913892
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/273	119/9376	3.4632930095115	VCAM1/CXCL2/TNFAIP3/PTGS2/CCL2/IL15/SELE/CEBPB/CCL5/SOCS3/JUNB/CREB5	4.68305343858674
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/273	44/9376	5.46386946386946	HLA-DPA1/HLA-DPB1/CPE/GZMB/HLA-C/HLA-DRB5/HLA-DQA2	5.13955064161121
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/273	268/9376	2.43485867366464	ATP5F1E/MT-ND3/SNCA/UBA52/MT-CO2/NDUFA4/UBB/NDUFB1/UBC/NDUFA3/HSPA5/TXN/COX7C/RPS27A/UQCRQ/PSMB3/COX6C/UCHL1/SLC39A7	4.12704974617882
NA	NA	hsa04518	Integrin signaling	13/273	154/9376	2.89919604205318	THBS1/VCAM1/ACTN1/LIMS1/FLNA/COL1A1/LAMB1/PDGFD/ITGAX/TNC/ACTB/PDGFRA/CCND2	4.11521271115325
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/273	50/9376	4.80820512820513	THBS1/VCAM1/CXCL8/SELP/CCL2/SELE/TGFB2	4.67554585320377
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/273	196/9376	2.62839201614712	CLEC2B/CXCL8/ANGPT2/ZFP36/CXCL2/HIF1A/UBA52/PTGS2/UBB/CDKN1A/HLA-C/UBC/MAP1LC3B/GNG5/RPS27A	3.98970100227186
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/273	160/9376	2.79047619047619	VCAM1/SELP/VCAN/HLA-DPA1/HLA-DPB1/CDH2/CLDN1/HLA-C/SELE/HLA-DRB5/NEGR1/HLA-DQA2/ALCAM	3.95577880177696
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/273	39/9376	5.28374189912651	HLA-DPA1/HLA-DPB1/GZMB/HLA-C/HLA-DRB5/HLA-DQA2	4.64222953801805
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/273	204/9376	2.52531781943547	LUM/DCN/THBS1/DDX5/HIF1A/HOXD10/FLNA/COL1A1/CDKN1A/TIAM1/CAV1/TGFB2/ACTB/MMP2/CD63	3.81432851796138
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/273	70/9376	3.9250654107797	HLA-DPA1/HLA-DPB1/CAV1/HLA-C/ACTB/HLA-DRB5/CD55/HLA-DQA2	4.25380687234581
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/273	298/9376	2.18973867296015	CSH1/CXCL8/CCL4L2/BMP2/LEPR/CXCL2/CCL3L1/CXCL14/INHBA/CCL2/IL13RA2/IL15/CXCL11/TGFB2/INHBB/XCL1/XCL2/CCL5/CXCR2	3.61442578603412
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/273	45/9376	4.57924297924298	HLA-DPA1/HLA-DPB1/GZMB/HLA-C/HLA-DRB5/HLA-DQA2	4.16781117018813
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/273	78/9376	3.52249459941768	HLA-DPA1/HLA-DPB1/PTGS2/EEF1A1/FCGR3B/TGFB2/HLA-DRB5/HLA-DQA2	3.87398081705691
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	17/273	275/9376	2.12310356310356	HSPA1B/ATP5F1E/MT-ND3/HSPA1A/MT-CO2/NDUFA4/CAV1/NDUFB1/NDUFA3/CCL5/HSPA5/COX7C/UQCRQ/PSMB3/COX6C/RYR2/CREB5	3.27352969715593
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	11/273	142/9376	2.66047567456018	VCAM1/SQSTM1/GSTT2B/PLAT/CCL2/CAV1/SELE/ACTB/HSP90AA1/TXN/MMP2	3.45268092259503
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/273	105/9376	2.94379905808477	HIF1A/UBA52/SQSTM1/GABARAP/UBB/UBC/MAP1LC3B/RPS27A/TOMM7	3.4686255331975
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/273	193/9376	2.31334813718233	CXCL8/CCL4L2/CXCL2/CCL3L1/CXCL14/TIAM1/CCL2/CXCL11/XCL1/XCL2/CCL5/GNG5/CXCR2	3.19257357847428
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/273	216/9376	2.22602089268756	SOD2/HSPA1B/VCAM1/CXCL8/SELP/HSPA1A/CXCL2/MMP1/CCL3L1/CCL2/SELE/HSP90AA1/CCL5/HSPA5	3.15683367121949
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/273	54/9376	3.81603581603582	HLA-DPA1/HLA-DPB1/GZMB/HLA-C/HLA-DRB5/HLA-DQA2	3.59381068094167
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/273	56/9376	3.67974882260597	HSPA1B/CXCL8/HSPA1A/CXCL2/EEF1A1/EEF1G	3.48301092314158
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/273	155/9376	2.43733900508094	THBS1/CTSS/HLA-DPA1/ATP6V0C/HLA-DPB1/FCGR3B/HLA-C/MRC2/ACTB/HLA-DRB5/HLA-DQA2	3.12471735563499
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/273	201/9376	2.22127457948353	CXCL8/DDX5/SMAD1/LMO2/PLAT/GZMB/CDKN1A/GADD45A/IGFBP3/BCL2A1/CEBPB/HMGA2/CCND2	3.03097950723637
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	13/273	203/9376	2.19939010086793	THBS1/ACTN1/MYL9/FLNA/COL1A1/LAMB1/PDGFD/CAV1/TNC/ACTB/PDGFRA/CCND2/MYL12A	2.99176496886518
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/273	41/9376	4.18833199321004	THBS1/CXCL8/MMP1/CDKN1A/MMP2	3.54301502994495
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/273	181/9376	2.27697164713739	CTSS/HLA-DPA1/ATP6V0C/HLA-DPB1/FCGR3B/TGFB2/ITGAX/MRC2/CEBPB/HLA-DRB5/CD74/HLA-DQA2	3.00413445022303
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/273	205/9376	2.17793263646922	ATP5F1E/MT-ND3/COL1A1/MT-CO2/NDUFA4/TGFB2/NDUFB1/NDUFA3/COX7C/MMP2/UQCRQ/COX6C/RYR2	2.9530019171481
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/273	138/9376	2.48871901045814	ATP5F1E/MT-ND3/ATP6V0C/MT-CO2/NDUFA4/NDUFB1/NDUFA3/COX7C/UQCRQ/COX6C	3.05097036201445
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/273	105/9376	2.61671027385313	VCAM1/CXCL8/CCL4L2/CXCL2/TNFAIP3/PTGS2/GADD45A/BCL2A1	2.88494971347246
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/273	87/9376	2.76333628057766	ASPH/MT-CO2/CACNA2D1/COX7C/UQCRQ/COX6C/RYR2	2.86144220438283
Human Diseases	Immune disease	hsa05310	Asthma	4/273	32/9376	4.29304029304029	HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQA2	3.23132253474136
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/273	224/9376	1.99319727891156	ZFP36/HLA-DPA1/FOSL1/HLA-DPB1/CDKN1A/IL15/HLA-C/TGFB2/CCND2/B2M/HLA-DRB5/HLA-DQA2/CREB5	2.60541083464394
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/273	88/9376	2.73193473193473	PROCR/PLAT/SERPINA1/ITGAX/CD55/CFD/F2R	2.826743776255
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/273	50/9376	3.43443223443223	HLA-DPA1/HLA-DPB1/IL15/HLA-DRB5/HLA-DQA2	2.98888824404527
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/273	227/9376	1.96685546465282	CXCL8/CCL4L2/CCL3L1/PTGS2/CDKN1A/CCL2/HLA-C/PDGFRA/CCL5/B2M/GNG5/CXCR2/CREB5	2.55365581056546
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/273	227/9376	1.96685546465282	SOD2/ATP5F1E/MT-ND3/HIF1A/MT-CO2/NDUFA4/GSTT2B/NDUFB1/NDUFA3/COX7C/PRKD1/UQCRQ/COX6C	2.55365581056546
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/273	253/9376	1.90047633525894	CXCL8/ACTN1/MYL9/UBA52/SQSTM1/UBB/UBC/MAP1LC3B/ACTB/MYL12A/UBE2V1/CCL5/RPS27A/PFN2	2.51442344482882
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/273	157/9376	2.18753645505238	CXCL8/LEPR/MT-CO2/NDUFA4/NDUFB1/NDUFA3/COX7C/SOCS3/UQCRQ/COX6C	2.59854091634099
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/273	112/9376	2.45316588173731	HSPA1B/HSPA1A/HLA-DPA1/HLA-DPB1/LAMB1/TGFB2/HLA-DRB5/HLA-DQA2	2.67916598795667
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/273	116/9376	2.36857395478085	VCAM1/ACTN1/MYL9/CLDN1/RAPGEF4/ACTB/MYL12A/MMP2	2.56842247964305
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/273	187/9376	2.02025425554837	CXCL8/CARD16/CXCL2/TNFAIP3/NAMPT/GABARAP/CCL2/MAP1LC3B/HSP90AA1/CCL5/TXN	2.44044926123881
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/273	75/9376	2.74754578754579	THBS1/CDKN1A/GADD45A/IGFBP3/SESN3/CCND2	2.63129210950164
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	22/273	480/9376	1.57411477411477	ATP5F1E/MT-ND3/SNCA/DKK1/UBA52/MT-CO2/SQSTM1/NDUFA4/PTGS2/UBB/NDUFB1/UBC/NDUFA3/MAP1LC3B/HSPA5/COX7C/RPS27A/UQCRQ/PSMB3/COX6C/UCHL1/RYR2	2.23612792393344
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/273	38/9376	3.61519182571814	NNMT/BST1/NAMPT/NT5E	2.7973261418815
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/273	99/9376	2.42838642838643	SELP/HLA-DPA1/HLA-DPB1/FCGR3B/HLA-DRB5/CFD/HLA-DQA2	2.47419670678403
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/273	101/9376	2.38029956841838	VCAM1/CXCL8/COL1A1/CCL2/SELE/TGFB2/MMP2	2.4151926051676
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/273	106/9376	2.26802128688921	PLAT/CDKN1A/PDGFD/PDGFRA/HSP90AA1/FOLH1/CREB5	2.27360125460957
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/273	180/9376	1.90801790801791	HLA-DPA1/HLA-DPB1/CCL2/HLA-C/CCL5/B2M/HLA-DRB5/CD74/SOCS3/HLA-DQA2	2.13012885495172
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/273	232/9376	1.77643046608564	TMSB4X/ACTN1/MYL9/TIAM1/PDGFD/ITGAX/ENAH/ACTB/PDGFRA/MYL12A/F2R/PFN2	2.07373444914814
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/273	110/9376	2.18554778554779	DCN/THBS1/BMP2/SMAD1/INHBA/TGFB2/INHBB	2.16592766579296
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/273	235/9376	1.75375263034838	ATP5F1E/MT-ND3/MT-CO2/NDUFA4/NDUFB1/NDUFA3/ACTB/COX7C/UQCRQ/NDUFAF8/COX6C/CREB5	2.02647200136827
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/273	66/9376	2.6018426018426	HLA-DPA1/HLA-DPB1/TGFB2/HLA-DRB5/HLA-DQA2	2.26147430381984
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/273	212/9376	1.78201672541295	THBS1/ANGPT2/TIAM1/PDGFD/RAPGEF4/ENAH/ACTB/PDGFRA/F2R/PFN2/PRKD1	1.99441771117193
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/273	142/9376	1.93489139968013	JUND/FOSL1/SQSTM1/FCGR3B/TGFB2/FHL2/SOCS3/JUNB	1.94395000771616
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/273	71/9376	2.41861424960017	CXCL8/CXCL2/ATP6V0C/CCL5/CXCR2	2.07782991150888
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/273	168/9376	1.83987441130298	CSH1/LEPR/CDKN1A/IL13RA2/IL15/SOCS2/PDGFRA/CCND2/SOCS3	1.90222123536172
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/273	169/9376	1.82898758046687	HIF1A/UBA52/SQSTM1/GABARAP/UBB/UBC/MAP1LC3B/VMP1/RPS27A	1.88324574678126
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	16/273	362/9376	1.5179810980916	THBS1/CSH1/ANGPT2/COL1A1/EREG/CDKN1A/LAMB1/PDGFD/TNC/PDGFRA/CCND2/HSP90AA1/GNG5/F2R/AREG/CREB5	1.7405404100375
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/273	122/9376	1.97057587221522	CSH1/SSTR1/IGFBP3/SOCS2/SOCS3/JUNB/CREB5	1.86861292714493
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	9/273	173/9376	1.78669885028267	CXCL8/HLA-DPA1/HLA-DPB1/CCL2/ACTB/CCL5/HLA-DRB5/SOCS3/HLA-DQA2	1.80859591830764
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/273	174/9376	1.77643046608564	HSPA1B/HSPA1A/TXNDC5/CRYAB/KRTCAP2/PPP1R15A/HSP90AA1/HSPA5/SSR4	1.79023798717522
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	10/273	205/9376	1.67533279728402	HLA-DPA1/TNFAIP3/HLA-DPB1/CDKN1A/GADD45A/HLA-C/CCND2/B2M/HLA-DRB5/HLA-DQA2	1.69301620767581
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/273	103/9376	2.00064013656247	CXCL8/ACTN1/CXCL2/COL1A1/LAMB1/TGFB2	1.76832094768439
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/273	157/9376	1.7500291640419	CXCL8/SQSTM1/CDKN1A/GADD45A/IGFBP3/HLA-C/TGFB2/CCND2	1.64119717160679
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/273	59/9376	2.32842863351338	NME2/NME3/CDA/NT5E	1.77255972138581
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/273	109/9376	1.8905131565682	HIF1A/HLA-DPA1/HLA-DPB1/HSP90AA1/HLA-DRB5/HLA-DQA2	1.6194170148169
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/273	300/9376	1.48825396825397	JUND/HSPA1B/HSPA1A/ANGPT2/FLNA/EREG/GADD45A/PDGFD/CACNA2D1/TGFB2/MAP3K13/PDGFRA/AREG	1.48844864750127
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/273	85/9376	2.02025425554837	NME2/NME3/CDA/NT5E/GDA	1.63629400069693
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/273	86/9376	1.99676292699548	RAPGEF4/KCNMB4/KCNN3/RYR2/CREB5	1.60808105580036
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/273	62/9376	2.21576273189176	SOD2/HSPA1B/HSPA1A/CRYAB	1.66322592059945
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/273	87/9376	1.97381162898404	EREG/CDKN1A/GADD45A/TGFB2/AREG	1.5802463347382
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	13/273	308/9376	1.44959802102659	SOD2/ATP5F1E/MT-ND3/MT-CO2/NDUFA4/NDUFB1/NDUFA3/COX7C/UQCRQ/PSMB3/POLR2L/COX6C/CREB5	1.38937245279488
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/273	368/9376	1.3999044433827	ATP5F1E/MT-ND3/MT-CO2/SQSTM1/NDUFA4/NDUFB1/NDUFA3/MAP1LC3B/ACTB/HSPA5/COX7C/PFN2/UQCRQ/PSMB3/COX6C	1.35531623477176
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/273	42/9376	2.45316588173731	FTH1/SAT1/MAP1LC3B	1.63448383574177
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/273	93/9376	1.84646894324314	LYZ/GUCY1A1/CST3/BST1/ATP2B1	1.42063666124551
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/273	68/9376	2.02025425554837	ALDH1A1/DHRS4/DHRS3/DHRS9	1.46220873614182
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/273	233/9376	1.47400525082929	DCN/THBS1/VCAN/MYL9/COL1A1/COL5A2/PDLIM3/ACTB/FHL2/PDLIM1	1.26879495641815
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/273	149/9376	1.61349165376011	MT-ND3/NDUFA4/PTGS2/GABRG2/NDUFB1/NDUFA3/GNG5	1.30721259309249
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/273	388/9376	1.32774442052793	ATP5F1E/MT-ND3/BACE2/SNCA/DKK1/MT-CO2/NDUFA4/PTGS2/NDUFB1/NDUFA3/COX7C/UQCRQ/PSMB3/COX6C/SLC39A7	1.14181127798658
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/273	154/9376	1.56110556110556	GUCY1A1/MYL9/PTGS2/CDKN1A/CACNA2D1/ACTB/RYR2	1.21581378974658
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/273	73/9376	1.88188067640122	CDKN1A/GADD45A/PDGFD/PDGFRA	1.30988882315972
NA	NA	hsa03272	Virion - Hepatitis viruses	3/273	48/9376	2.14652014652015	CLDN1/CD63/EPCAM	1.37905863144746
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/273	100/9376	1.71721611721612	HLA-DPA1/HLA-DPB1/HLA-DRB5/CD55/HLA-DQA2	1.24866046345983
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/273	128/9376	1.60989010989011	NME2/GUCY1A1/PDE3A/NME3/NT5E/GDA	1.20311559280769
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	7/273	157/9376	1.53127551853666	CCN2/BMP2/SMAD1/TGFB2/ACTB/CCND2/AREG	1.16252529923969
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/273	103/9376	1.66720011380206	CXCL8/CCL3L1/CCL2/TGFB2/CCL5	1.17906917224675
NA	NA	hsa04081	Hormone signaling	9/273	219/9376	1.41141050730092	CSH1/PENK/RAMP3/LEPR/SMAD1/RAMP1/SSTR1/RAPGEF4/GNG5	1.06683073713841
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/273	133/9376	1.54936792530777	SOD2/GABARAP/CDKN1A/GADD45A/TGFB2/CCND2	1.1049874206762
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/273	28/9376	2.45316588173731	B3GNT5/GCNT2	1.33355074656659
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/273	137/9376	1.50413090559076	CTSS/GZMB/GADD45A/BCL2A1/ACTB/CTSW	1.0293565039109
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/273	109/9376	1.5754276304735	CXCL8/CCL4L2/CCL3L1/CXCL11/CCL5	1.04642731969922
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	9/273	226/9376	1.36769425265	PDE3A/MYL9/SSTR1/TIAM1/RAPGEF4/F2R/ATP2B1/RYR2/CREB5	0.968958561614254
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/273	82/9376	1.67533279728402	NME2/GSTT2B/NME3/CDA	1.06364848061507
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/273	110/9376	1.56110556110556	ANGPT2/TIMP1/HIF1A/CDKN1A/PFKP	1.02510761105026
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/273	140/9376	1.47189952904239	CCN2/APLN/PLAT/MAP1LC3B/GNG5/RYR2	0.974195883217783
NA	NA	hsa04981	Folate transport and metabolism	2/273	31/9376	2.21576273189176	BHMT2/FOLH1	1.17412601494936
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/273	142/9376	1.4511685497601	UBA52/UBB/UBC/RPS27A/UBE2QL1/SOCS3	0.938129397796909
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/273	143/9376	1.4410205179436	ACTN1/HLA-DPA1/HLA-DPB1/FCGR3B/HLA-DRB5/HLA-DQA2	0.920301407573893
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/273	86/9376	1.59741034159639	CDH2/CACNA2D1/ACTB/RYR2	0.963804157279544
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/273	89/9376	1.54356504918303	THBS1/COL1A1/LAMB1/TNC	0.892243710084184
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/273	61/9376	1.68906503332733	FTH1/STEAP1/ATP2B1	0.934993066619112
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/273	149/9376	1.38299284608009	CXCL8/PDGFD/RAPGEF4/PDGFRA/F2R/CXCR2	0.816071528262388
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/273	63/9376	1.63544392115821	BMP2/CDKN1A/GADD45A	0.876349600609899
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/273	93/9376	1.47717515459451	ACTN1/MYL9/ACTB/MYL12A	0.800847478060086
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/273	93/9376	1.47717515459451	HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQA2	0.800847478060086
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/273	93/9376	1.47717515459451	PTGS2/CDKN1A/GADD45A/LAMB1	0.800847478060086
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/273	37/9376	1.85644985644986	VCAM1/SELE	0.903914401099556
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/273	37/9376	1.85644985644986	CDKN1A/GADD45A	0.903914401099556
NA	NA	hsa04382	Cornified envelope formation	8/273	217/9376	1.26615013250958	S100A8/S100A6/S100A9/S100A12/UGCG/CLDN1/S100A4/KRT6A	0.686921665924811
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/273	12/9376	2.86202686202686	SLAMF1	1.11768790892847
Organismal Systems	Immune system	hsa04611	Platelet activation	5/273	126/9376	1.36286993429851	GUCY1A1/COL1A1/ACTB/MYL12A/F2R	0.710133634067563
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/273	99/9376	1.38764938764939	HIF1A/PDGFD/PDGFRA/SLC22A4	0.671471542467977
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/273	99/9376	1.38764938764939	CACNA2D1/TGFB2/ACTB/RYR2	0.671471542467977
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/273	130/9376	1.32093547478163	MMP1/COL1A1/GNG5/MMP2/CREB5	0.638097652192815
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/273	70/9376	1.47189952904239	HIF1A/CDKN1A/TGFB2	0.686264810455016
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/273	71/9376	1.4511685497601	SOCS2/CCND2/SOCS3	0.660822001532717
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/273	71/9376	1.4511685497601	HIF1A/PFKP/PDGFRA	0.660822001532717
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/273	134/9376	1.28150456508665	RAMP3/GUCY1A1/MYL9/RAMP1/KCNMB4	0.56836790975177
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/273	103/9376	1.33376009104164	COL8A1/COL12A1/COL1A1/COL5A2	0.589817396809112
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/273	166/9376	1.24136104858996	GUCY1A1/PDE3A/MYL9/KCNMB4/ATP2B1/CREB5	0.543333025006636
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/273	136/9376	1.26265890971773	HSPA1B/HSPA1A/TNFAIP3/SLAMF1/CCND2	0.534318604418978
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/273	105/9376	1.30835513692657	CACNA2D1/TGFB2/ACTB/RYR2	0.550246434572277
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/273	170/9376	1.21215255332902	ACTN1/MYL9/CLDN1/TIAM1/ACTB/MYL12A	0.483405880060844
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/273	16/9376	2.14652014652015	MIF	0.794837681409739
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/273	139/9376	1.23540727857275	HSPA1B/HSPA1A/HSP90AA1/MMP2/CREB5	0.484213067229693
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/273	76/9376	1.3556969346443	CDKN1A/GADD45A/PDGFRA	0.539163066517306
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/273	46/9376	1.49323140627488	PSME2/PSMB3	0.580715618453723
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/273	77/9376	1.33809048094762	CDKN1A/GADD45A/TGFB2	0.515863585434718
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/273	77/9376	1.33809048094762	CDKN1A/GADD45A/TGFB2	0.515863585434718
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/273	47/9376	1.46146052529031	SOCS2/SOCS3	0.549212772815363
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/273	49/9376	1.40180907527846	ST6GAL1/GALNT15	0.488339083174952
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/273	50/9376	1.37377289377289	SAT1/P4HA3	0.458901830307523
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/273	248/9376	1.10788136594588	CXCL8/MYL9/FLNA/ACTB/MYL12A/HSP90AA1/TXN/PFN2	0.298166708915995
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/273	83/9376	1.24136104858996	CCL4L2/CCL5/POLR2L	0.382474910719896
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/273	51/9376	1.34683617036558	ATP6V0C/ACTB	0.430090391682787
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/273	20/9376	1.71721611721612	CYP51A1	0.556025388277498
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/273	86/9376	1.19805775619729	EREG/CDKN1A/AREG	0.319527258758725
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/273	21/9376	1.63544392115821	DSEL	0.50482362525445
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/273	154/9376	1.11507540078969	CACNA2D1/RAPGEF4/ATP2B1/RYR2/CREB5	0.249347482611019
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/273	54/9376	1.27201193867861	BHMT2/ADI1	0.347140261853257
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/273	89/9376	1.15767378688727	GUCY1A1/PDGFD/PDGFRA	0.258816207566632
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/273	89/9376	1.15767378688727	GABARAP/GABRG2/GNG5	0.258816207566632
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/273	56/9376	1.22658294086866	KRTCAP2/ST6GAL1	0.29450180232773
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/273	56/9376	1.22658294086866	CCND2/GAS1	0.29450180232773
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/273	90/9376	1.14481074481074	SOD2/SESN3/CREB5	0.239046501828834
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/273	91/9376	1.13223040695568	PDE3A/GABRG2/GNG5	0.219500627948249
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/273	333/9376	1.03136103136103	THBS1/ATP6V0C/COL1A1/PTGS2/CDKN1A/LAMB1/HLA-C/TNC/CCND2/CREB5	0.100909226793417
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/273	59/9376	1.16421431675669	CDKN1A/GADD45A	0.219115785533742
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/273	26/9376	1.32093547478163	NR5A2	0.283774445438905
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/273	26/9376	1.32093547478163	FOLH1	0.283774445438905
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/273	97/9376	1.06219553642234	GUCY1A1/GNG5/RYR2	0.106627490468552
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/273	98/9376	1.05135680645885	ATP2B1/PRKD1/CREB5	0.0885031144878246
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/273	63/9376	1.0902959474388	PTGDS/PTGS2	0.124528404222452
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/273	63/9376	1.0902959474388	POLE4/POLR2L	0.124528404222452
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/273	170/9376	1.01012712777419	GSTT2B/CDKN1A/GADD45A/TGFB2/ACTB	0.0230754381097499
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/273	28/9376	1.22658294086866	ATP6V0C	0.207932111365982
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/273	65/9376	1.0567483798253	KISS1/KCNN3	0.0795035776379372
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/273	138/9376	0.995487604183256	CXCL8/CCL2/ARHGEF28/ACTB	-0.00924767253044355
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/273	102/9376	1.01012712777419	BST1/ATP2B1/RYR2	0.0178085073543586
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/273	250/9376	0.961641025641026	HSPA1B/HSPA1A/CAV1/HLA-C/PDGFRA/VPS28/CXCR2	-0.106456319912463
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/273	31/9376	1.10788136594588	PFKP	0.104186709267059
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/273	31/9376	1.10788136594588	HYI	0.104186709267059
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/273	31/9376	1.10788136594588	HSPA5	0.104186709267059
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/273	69/9376	0.995487604183256	GUCY1A1/PDE3A	-0.00651480718542367
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/273	323/9376	0.956962542101861	THBS1/HOXD10/PTGS2/CDKN1A/TGFB2/TNC/HMGA2/PDGFRA/CCND2	-0.136309555692043
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/273	70/9376	0.981266352694924	LEPR/SOCS3	-0.0272436019231422
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/273	70/9376	0.981266352694924	GSTT2B/PTGS2	-0.0272436019231422
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/273	32/9376	1.07326007326007	PFKP	0.0718870419297299
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/273	32/9376	1.07326007326007	GABARAP	0.0718870419297299
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/273	33/9376	1.04073704073704	STX11	0.040595506391958
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/273	73/9376	0.940940338200612	MAP1B/APOBEC3A	-0.0877234221825882
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/273	73/9376	0.940940338200612	CDKN1A/GADD45A	-0.0877234221825882
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/273	34/9376	1.01012712777419	POLR2L	0.0102442579845585
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/273	34/9376	1.01012712777419	NR1D1	0.0102442579845585
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/273	35/9376	0.981266352694924	PFKP	-0.0192280111846276
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/273	75/9376	0.915848595848596	GSTT2B/CDKN1A	-0.126707367168925
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/273	75/9376	0.915848595848596	HSPA5/CREB5	-0.126707367168925
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/273	76/9376	0.903797956429535	MMP1/UBC	-0.145822422868366
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/273	36/9376	0.954008954008954	GALNT15	-0.0478768743452497
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/273	36/9376	0.954008954008954	POLE4	-0.0478768743452497
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/273	115/9376	0.895938843764931	JUND/CDKN1A/CREB5	-0.194438971651048
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/273	37/9376	0.928224928224928	FOLH1	-0.0757528540974659
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/273	37/9376	0.928224928224928	MIF	-0.0757528540974659
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/273	78/9376	0.880623649854419	BTG1/PFKP	-0.183335056725596
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/273	78/9376	0.880623649854419	CAV1/ACTB	-0.183335056725596
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/273	157/9376	0.875014582020952	THBS1/HIF1A/PTGS2/CEBPB	-0.273490317861622
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/273	158/9376	0.869476515046135	CDKN1A/GADD45A/TGFB2/CCND2	-0.286532271567724
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/273	80/9376	0.858608058608059	PDGFD/PDGFRA	-0.219935980619021
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/273	39/9376	0.880623649854419	BHMT2	-0.129366435195267
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/273	122/9376	0.844532516663664	LEPR/PFKP/CREB5	-0.299315651078279
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/273	122/9376	0.844532516663664	HIF1A/PFKP/ACTB	-0.299315651078279
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/273	200/9376	0.858608058608059	CXCL8/CLDN1/ACTB/F2R/MYO1D	-0.350015795300976
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/273	83/9376	0.82757403239331	SOD2/DHRS4	-0.273236327698415
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/273	41/9376	0.837666398642008	GABRG2	-0.18039225234427
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/273	163/9376	0.842805456302389	CXCL8/CDKN1A/TGFB2/CREB5	-0.350594762850264
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/273	205/9376	0.837666398642008	ACTN1/CDKN1A/HLA-C/CCND2/CREB5	-0.406959974778005
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/273	168/9376	0.817721960579103	FTH1/TNFAIP3/SQSTM1/HSP90AA1	-0.412839291994392
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/273	44/9376	0.780552780552781	KRTCAP2	-0.252664220277642
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/273	44/9376	0.780552780552781	POLE4	-0.252664220277642
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/273	44/9376	0.780552780552781	CREB5	-0.252664220277642
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/273	250/9376	0.824263736263736	OSBPL1A/NCOA7/CTSS/ATP6V0C/CD63/CTSW	-0.487714706275813
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/273	46/9376	0.746615703137442	FTH1	-0.298326945095212
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/273	133/9376	0.774683962653887	GZMB/FCGR3B/HLA-C	-0.453196074023763
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/273	254/9376	0.811283204983992	ASPH/PDGFD/PDGFRA/F2R/ATP2B1/RYR2	-0.528028138996882
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/273	49/9376	0.700904537639231	CREB5	-0.363505985447997
NA	NA	hsa04517	IgSF CAM signaling	7/273	299/9376	0.804047680301861	ACTN1/MYL9/CDH2/SLAMF1/ITGAX/ACTB/MYL12A	-0.596333937503193
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/273	51/9376	0.673418085182791	ENPP2	-0.404974324079857
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/273	52/9376	0.660467737390814	PTGS2	-0.425163797362003
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/273	99/9376	0.693824693824694	CDKN1A/MMP2	-0.530345233742723
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/273	53/9376	0.648006081968346	ATP2B1	-0.445010176532232
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/273	144/9376	0.715506715506715	SMAD1/INHBA/INHBB	-0.59577195789634
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/273	55/9376	0.624442224442224	UGCG	-0.483728348014862
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/273	150/9376	0.686886446886447	CDKN1A/GADD45A/TGFB2	-0.669445861642343
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/273	194/9376	0.708130357614894	MYL9/ACTB/MYL12A/MYO1D	-0.711370476639412
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/273	107/9376	0.641949950361165	PFKP/CREB5	-0.645050737918639
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/273	59/9376	0.582107158378345	GSTT2B	-0.557606182392292
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/273	59/9376	0.582107158378345	PTGS2	-0.557606182392292
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/273	238/9376	0.721519376981562	ANGPT2/TIAM1/PDGFD/PDGFRA/GNG5	-0.753585570192168
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/273	154/9376	0.669045240473812	NME2/NME3/DHRS3	-0.717118824524538
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/273	60/9376	0.572405372405372	PTGS2	-0.575397294608735
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/273	60/9376	0.572405372405372	GUCY1A1	-0.575397294608735
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/273	109/9376	0.630171052189401	SOCS3/CREB5	-0.672541765653797
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/273	156/9376	0.660467737390814	CLDN1/CDKN1A/SOCS3	-0.74054691413162
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/273	370/9376	0.742579942579943	CSH1/PENK/LEPR/APLN/KISS1/SSTR1/GABRG2/F2R	-0.874887001109115
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/273	115/9376	0.597292562509954	GNG5/CREB5	-0.752461560631833
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/273	115/9376	0.597292562509954	PTGS2/GNG5	-0.752461560631833
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/273	65/9376	0.528374189912651	CREB5	-0.660740259435845
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/273	66/9376	0.52036852036852	DHRS9	-0.677141602578167
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/273	67/9376	0.512601826034662	PFKP	-0.693337155394188
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/273	68/9376	0.505063563887093	BCL2A1	-0.709333361545462
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/273	69/9376	0.497743802091628	CREB5	-0.725136362132863
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/273	214/9376	0.641949950361165	HLA-C/B2M/GNG5/APOBEC3A	-0.917550912760457
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/273	72/9376	0.477004477004477	CXCL8	-0.771443384126524
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/273	73/9376	0.470470169100306	GSTT2B	-0.78652954485374
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/273	75/9376	0.457924297924298	PFKP	-0.816207236336566
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/273	76/9376	0.451898978214768	ACTB	-0.830807912254038
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/273	178/9376	0.578836893443635	DKK1/FOSL1/CCND2	-0.98239989941616
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/273	78/9376	0.44031182492721	CXCL8	-0.85955436902268
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/273	133/9376	0.516455975102592	GNG5/CREB5	-0.972590572257085
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/273	79/9376	0.434738257523068	GSTT2B	-0.873708203518829
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/273	79/9376	0.434738257523068	ATP6V0C	-0.873708203518829
NA	NA	hsa04519	Cadherin signaling	8/273	404/9376	0.68008559097668	ACTN1/CDH2/GABRG2/ENAH/ACTB/PDGFRA/MYO1D/KRT6A	-1.13829424909889
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/273	184/9376	0.559961777353082	MYL9/ENAH/MYL12A	-1.04392427322928
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/273	138/9376	0.497743802091628	SOCS2/SOCS3	-1.02932035071207
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/273	83/9376	0.413787016196655	L3MBTL4	-0.928947566116727
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/273	144/9376	0.477004477004477	CXCL8/CXCL2	-1.09523171086809
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/273	195/9376	0.528374189912651	SELP/FCGR3B/ACTB	-1.15250963958809
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/273	90/9376	0.381603581603582	HIF1A	-1.02081859156473
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/273	148/9376	0.464112464112464	CDKN1A/GADD45A	-1.13795584561226
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/273	91/9376	0.377410135651894	IFITM1	-1.03349047563944
NA	NA	hsa04082	Neuroactive ligand signaling	3/273	199/9376	0.517753603180739	PENK/GABRG2/GNG5	-1.19074798190127
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/273	93/9376	0.369293788648627	MMP2	-1.05852007149617
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/273	155/9376	0.443152546378353	CDKN1A/CREB5	-1.21056403299563
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/273	98/9376	0.350452268819616	FCGR3B	-1.11936471875503
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/273	217/9376	0.474806299691092	GSTT2B/HSP90AA1/CREB5	-1.35550160410469
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/273	105/9376	0.327088784231641	PTGS2	-1.20078102460286
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/273	108/9376	0.318002984669651	EEF1A1	-1.23445717870952
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/273	110/9376	0.312221112221112	HSP90AA1	-1.25653249843514
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/273	116/9376	0.296071744347606	PFKP	-1.32107231001853
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/273	116/9376	0.296071744347606	GNG5	-1.32107231001853
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/273	117/9376	0.29354121661814	ACTB	-1.33159577416565
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/273	243/9376	0.424003979559535	HSPA1B/HSPA1A/DDX5	-1.57539905716883
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/273	191/9376	0.359626411982433	GNG5/CREB5	-1.54840728149305
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/273	144/9376	0.238502238502239	PSMB3	-1.59469146383984