category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	67/1360	224/9376	2.06207983193277	PTEN/ANAPC5/CREBBP/FDPS/EP300/TGFB1/HLA-F/NFKB2/NFYB/RELB/ATM/ATF4/BUB3/SMAD3/CRTC2/VDAC2/PIK3CB/JAK1/ANAPC15/CDKN2C/DLG1/CDC26/HLA-DRB1/TP53/TBPL1/MYC/NFKBIA/NRAS/KRAS/IKBKB/PPP3CA/PPP3R1/MAP2K4/BAX/ANAPC1/TCF3/TRRAP/KAT2B/CDKN1A/EGR2/NFATC3/HLA-DPA1/HLA-DPB1/HLA-DRB5/SLC25A5/PIK3R3/STAT5A/ETS1/TBP/CDKN2B/ELK1/CHEK1/ICAM1/HLA-DQB1/MAPK8/B2M/MAP3K1/JAK3/PIK3CD/POLB/HLA-DMA/HLA-DQA2/MSX2/PTTG1/MSX1/TSPO/NFKB1	6.62673194618499
Genetic Information Processing	Transcription	hsa03040	Spliceosome	71/1360	243/9376	2.01433067053982	SF1/CDC5L/ACIN1/DDX39B/SNRNP27/LSM2/SLU7/PRPF40A/SYF2/DDX23/SNW1/PQBP1/SNRPB/SNRPD1/ISY1/HNRNPM/PLRG1/HSPA1A/SRSF10/LSM5/SNRPF/SRSF8/BUD31/SRSF6/DHX15/TCERG1/SNRNP40/RBMX/SF3B1/CCDC12/LSM7/RBM17/DHX8/PHF5A/SRSF4/SRSF9/CTNNBL1/NCBP1/RBM25/PRPF38B/RP9/RBM8A/SF3A3/SMNDC1/MAGOH/BCAS2/SNIP1/HNRNPC/CWC25/RBM22/HSPA1L/SRSF2/PRPF18/LSM6/THOC6/SRSF7/PPIH/TRA2B/CHERP/HNRNPA3/THOC1/RBMXL1/HNRNPK/PRPF3/ALYREF/PRPF38A/HNRNPA1/DDX5/THOC3/SRSF3/HSPA1B	6.59860609185832
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	57/1360	180/9376	2.18313725490196	IFNGR1/PPP1CA/IRF3/TNFRSF14/HLA-F/IRF9/TAP2/SRSF8/NXF1/IFIH1/IRF7/SRSF6/MYD88/BIRC2/PPP1CB/SRSF4/SRSF9/PIK3CB/JAK1/IFNGR2/SRPK1/SP100/TSC1/TBK1/HLA-DRB1/TP53/IFNAR2/NFKBIA/ZC3HAV1/IKBKB/SRSF2/TRAF5/BAX/BCL2/CASP3/SRSF7/CYCS/BID/HLA-DPA1/HLA-DPB1/HLA-DRB5/APAF1/PIK3R3/ALYREF/JAK2/HLA-DQB1/TICAM1/B2M/PILRB/TRAF2/PIK3CD/HLA-DMA/HLA-DQA2/SRSF3/CGAS/SYK/NFKB1	6.60158377815511
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	54/1360	173/9376	2.15192111526692	HNRNPUL1/CALCOCO2/CREBBP/CXCL8/IFNGR1/IRF3/FDPS/EP300/IRF9/NXF1/IFIH1/IRF7/MYD88/NUP98/PABPN1/PIK3CB/JAK1/IFNGR2/RAE1/IL1A/TBK1/HLA-DRB1/MX2/IFNAR2/NFKBIA/IKBKB/BAX/CASP3/MX1/CYCS/TPSB2/KPNA2/BID/HLA-DPA1/HLA-DPB1/HLA-DRB5/SLC25A5/APAF1/PIK3R3/TNFSF10/JAK2/ICAM1/NXT1/HLA-DQB1/TICAM1/TNFRSF10B/RSAD2/PIK3CD/HLA-DMA/HLA-DQA2/CPSF4/TPSAB1/PYCARD/NFKB1	6.29879273424808
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	38/1360	103/9376	2.54346087949743	ACIN1/PPP2R2A/DDX39B/PPP1CA/GSPT1/WDR33/PELO/PPP2R5C/PAPOLA/NXF1/PABPC4/UPF3A/PABPN1/RNMT/FIP1L1/PPP1CB/HBS1L/ETF1/PNN/PPP2R2D/NCBP1/PYM1/MSI2/DDX19A/RBM8A/MAGOH/SRRM1/PCF11/SMG1/RNGTT/PPP2R5A/ALYREF/NXT1/SAP18/PABPC1/UPF3B/CPSF4/CLP1	6.48754445680265
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	44/1360	137/9376	2.21416917131816	CAPN2/ATM/ENDOG/ATF4/ITPR2/BIRC2/PIK3CB/CTSH/EIF2AK3/CFLAR/TP53/ERN1/ITPR1/NFKBIA/NRAS/CTSF/KRAS/IKBKB/DDIT3/BAX/BCL2/CASP3/CYCS/BID/APAF1/PIK3R3/PARP2/CASP2/TNFSF10/TUBA1B/MAPK8/TNFRSF10B/LMNB2/TRAF2/PIDD1/BCL2L11/PIK3CD/TUBA1C/CTSW/GZMB/CASP10/BCL2A1/ITPR3/NFKB1	5.89662133899048
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	57/1360	205/9376	1.91690100430416	PSMD14/CIR1/LYN/IRF3/SNW1/HLA-F/IRF9/PSMD11/NFKB2/TAP2/RELB/IRF7/MYD88/PSMD12/PIK3CB/JAK1/HDAC1/SIN3A/TBK1/HLA-DRB1/TP53/MYC/IFNAR2/NFKBIA/MDM2/IKBKB/MAPK13/MAP2K4/CD58/DDB2/NFKBIE/TRAF5/BAX/BCL2/CASP3/CYCS/CDKN1A/BID/HLA-DPA1/HLA-DPB1/HLA-DRB5/APAF1/PIK3R3/SEM1/ICAM1/HLA-DQB1/MAPK8/HES1/B2M/TRAF2/BCL2L11/JAK3/PIK3CD/HLA-DMA/HLA-DQA2/SYK/NFKB1	5.46722906607276
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	48/1360	163/9376	2.03016961385781	DDB1/GRB2/CREBBP/CXCL8/IRF3/EP300/SOS2/TGFB1/IFIH1/IRF7/MYD88/ATF4/SMAD3/PIK3CB/JAK1/TBK1/TP53/MYC/NFKBIA/PCNA/NRAS/KRAS/IKBKB/MAPK13/MAP2K4/DDB2/BAX/BCL2/CASP3/CYCS/CDKN1A/EGR2/NFATC3/BID/APAF1/PIK3R3/STAT5A/ELK1/JAK2/MAPK8/TICAM1/BRAF/MAP3K1/JAK3/PIK3CD/CASP10/PTK2B/NFKB1	5.46484993138509
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	35/1360	108/9376	2.23420479302832	ACIN1/DDX39B/UBE2I/NUP58/KPNA4/RANBP2/NXF1/UPF3A/XPOT/NUP98/PNN/NUP214/NCBP1/SUMO1/RAE1/PYM1/DDX19A/RBM8A/MAGOH/SRRM1/SEH1L/THOC6/KPNA2/THOC1/NUP42/ALYREF/NUP88/NXT1/SAP18/NUP93/THOC3/NUP35/UPF3B/SUMO2/NUP107	5.31352015140679
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	64/1360	253/9376	1.74396651941409	CALCOCO2/ARPC4/CXCL8/PXN/IRF3/ATG12/RRAGC/CAPN2/UBE2N/UBE2D1/ATM/ARHGEF2/MYD88/ROCK1/ACTN1/ARF6/ITPR2/PIK3C3/SEPTIN6/PIK3CB/CYTH2/ACTR3/ARPC5L/FNBP1/FOXO3/TBK1/ACTN4/TP53/TECPR1/ARPC5/ITPR1/NFKBIA/MDM2/CASP4/ARPC1B/BCL10/IKBKB/MAPK13/TRAF5/RPS27A/BAX/BCL2/ATG14/CYCS/MALT1/PIK3R3/SEPTIN7/MAP1LC3B2/UBC/MAPK8/RIPK2/FNBP1L/TIFA/NAIP/TRAF2/RRAGB/CYTH1/PIK3CD/CGAS/PLCB2/CDC42/PYCARD/ITPR3/NFKB1	4.94107052586839
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	61/1360	238/9376	1.7669797330697	RPLP1/CXCL8/IRF3/RPL34/RPL39/IRF9/IFIH1/MYD88/RPL30/RPS23/PIK3CB/JAK1/RSL24D1/RPS15A/RPS12/RPS3A/TBK1/RPL22L1/MX2/IFNAR2/NFKBIA/IKBKB/RPL37/MAPK13/RPS14/RPS24/RPS3/RPS27A/HBEGF/MX1/RPS19/RPL32/RPL26/PIK3R3/RPL14/RPL41/RPS4X/ADAM17/RPL10/RPS13/AGTR1/MAPK8/FAU/RPS28/IL6R/RPS7/PIK3CD/RPS21/RPL9/RPLP2/RPL21/RPL23/RPS11/RPL24/RPS29/RPL19/CGAS/SYK/RPS20/RPL27A/NFKB1	4.9365441780462
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	54/1360	205/9376	1.81601147776184	DDB1/GRB2/CREBBP/LYN/GTF2H1/PXN/IRF3/EP300/SNW1/HLA-F/IRF9/NFKB2/IRF7/ATP6V0D1/YWHAH/ACTN1/HDAC5/GTF2A2/ATF4/PIK3CB/JAK1/HDAC1/SP100/DLG1/RASA2/ACTN4/TP53/TBPL1/NFKBIA/MDM2/NRAS/KRAS/TRAF5/DNAJA3/BAX/GTF2B/CASP3/KAT2B/CDKN1A/EGR2/PIK3R3/STAT5A/HNRNPK/HDAC8/TBP/CDKN2B/CHEK1/TRAF2/JAK3/PIK3CD/POLB/SYK/CDC42/NFKB1	4.86565250613311
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	52/1360	196/9376	1.82905162064826	CREBBP/CXCL8/LYN/IFNGR1/IRF3/EP300/GNG10/HLA-F/IRF9/IRF7/ATG3/ITPR2/PIK3C3/PIK3CB/JAK1/TBK1/TP53/MYC/IFNAR2/ITPR1/NFKBIA/NRAS/KRAS/IKBKB/MAPK13/PPP3CA/PPP3R1/MAP2K4/RPS27A/BAX/ATG14/GNB4/CASP3/CYCS/HIF1A/CDKN1A/NFATC3/BID/PIK3R3/JAK2/ICAM1/MAP1LC3B2/UBC/MAPK8/TICAM1/GNG5/TRAF2/PIK3CD/PREX1/SYK/ITPR3/NFKB1	4.8313055614602
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	49/1360	181/9376	1.86636334091648	CREBBP/IFNGR1/TCIRG1/EP300/TGFB1/NFYB/HSPA9/MYD88/ATP6V0D1/RAB5A/PIK3C3/JAK1/IFNGR2/ATP6V0B/IL1A/HLA-DRB1/CAMK2G/BCL10/MAPK13/PPP3CA/PPP3R1/NFYC/BAX/BCL2/CASP3/CYCS/MALT1/BID/HLA-DPA1/HLA-DPB1/CEBPG/HLA-DRB5/APAF1/FCGR3B/JAK2/HLA-DQB1/MAPK8/RIPK2/ATP6V0A2/FCGR1A/HLA-DMA/HLA-DQA2/LSP1/PLK3/CASP10/CAMP/SYK/NFKB1/CR1	4.84774454290553
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	25/1360	70/9376	2.46218487394958	GRB2/CREBBP/RAPGEF1/EP300/SOS2/TGFB1/FH/PAK2/PAK1/ELOC/PIK3CB/NRAS/KRAS/FLCN/PAK4/GAB1/HIF1A/CDKN1A/VHL/PIK3R3/ETS1/BRAF/PIK3CD/EPAS1/CDC42	5.05761796244321
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	31/1360	98/9376	2.18079231692677	PTEN/DGKZ/PIKFYVE/PIP5K1A/IMPA2/ITPR2/PPIP5K2/PIK3C3/PIK3CB/INPP1/CDS2/INPP4A/ITPR1/IMPA1/INPP5F/MTMR14/PIP4P1/PIP4K2A/MTMR4/DGKA/PIK3R3/SYNJ2/DGKD/DGKE/MTMR1/PIP4K2C/PIK3CD/PI4K2B/PIP5K1B/PLCB2/ITPR3	4.83989132990091
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	55/1360	216/9376	1.75544662309368	HSP90AA1/RXRA/CXCL8/LYN/IRF3/HSP90AB1/HSPA1A/IRF7/MYD88/HSPA4/ATF4/PIK3CB/EIF2AK3/TBK1/TP53/ERN1/CAMK2G/ITPR1/NFKBIA/NRAS/SOD2/KRAS/IKBKB/MAPK13/PPP3CA/PPP3R1/MAP2K4/HSPA1L/DDIT3/BAX/BCL2/ABCG1/CASP3/CYCS/ARHGEF1/NFATC3/BID/APAF1/PIK3R3/CYBA/TNFSF10/CCL3L1/JAK2/ICAM1/VCAM1/MAPK8/TICAM1/TNFRSF10B/TRAF2/PIK3CD/HSPA1B/PLCB2/CDC42/PYCARD/NFKB1	4.62657025188853
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	33/1360	109/9376	2.0872099298435	HSP90AA1/RXRA/IFNGR1/TGFB1/HSP90AB1/RUNX1/SMAD3/JAK1/IFNGR2/IL4R/HLA-DRB1/NFKBIA/IKBKB/MAPK13/PPP3CA/PPP3R1/NFKBIE/RARA/HIF1A/NFATC3/HLA-DPA1/HLA-DPB1/HLA-DRB5/STAT5A/JAK2/HLA-DQB1/MAPK8/EBI3/IL6R/JAK3/HLA-DMA/HLA-DQA2/NFKB1	4.70254885205006
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	26/1360	78/9376	2.29803921568627	CNOT4/BTG1/LSM2/LSM1/CNOT1/BTG3/CNOT7/XRN2/TOB1/HSPA9/LSM5/PABPC4/C1D/LSM7/CNOT9/ZCCHC7/CNOT2/TENT4B/PAN3/LSM6/EXOSC9/EXOSC3/DCP2/EXOSC8/PABPC1/CNOT6L	4.74150902886087
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	45/1360	169/9376	1.8357117995127	PTEN/CALCOCO2/BIRC6/EIF2AK4/SH3GLB1/ATG12/RRAGC/TP53INP2/ATG3/RRAS2/IGBP1/RAB8A/PIK3C3/PIK3CB/VMP1/SMCR8/TSC1/EIF2AK3/CFLAR/TBK1/ERN1/NRBF2/ITPR1/NRAS/DDIT4/KRAS/GABARAPL1/RPS27A/MTMR14/BCL2/ATG14/C9orf72/RAB33B/HIF1A/MTMR4/PIK3R3/DAPK1/ATG4D/ATG2A/MAP1LC3B2/UBC/MAPK8/ATG10/RRAGB/PIK3CD	4.51561651708511
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	82/1360	368/9376	1.53618925831202	NDUFA7/PSMD14/NDUFA10/PSMA6/ATXN2/NUP58/UQCRFS1/NDUFA2/RANBP2/PSMD11/PSMD9/PSMA2/NDUFB5/NXF1/NDUFA12/ATP5F1C/SPG11/PSMD12/NUP98/ATF4/MT-ATP8/RAB8A/COX5A/PSMA4/ATXN2L/RAB5A/NDUFA9/PSMA5/PIK3C3/NUP214/NCBP1/SMCR8/RAE1/EIF2AK3/TBK1/TP53/ERN1/NRBF2/MAPK13/PPP3CA/PPP3R1/SEH1L/DDIT3/BAX/MT-ND6/BCL2/ATG14/CASP3/C9orf72/SRSF7/CYCS/COX7A2/UQCRH/HNRNPA3/BID/MT-ATP6/APAF1/MT-ND3/MT-ND4L/TOMM40L/ALYREF/NUP88/ATG2A/TUBA1B/SEM1/ATP5MC2/NXT1/HNRNPA1/MAP1LC3B2/DNALI1/NUP93/TUBB2A/TRAF2/NUP35/NUP107/TUBA1C/SOD1/SRSF3/MT-ND4/UQCRB/MT-ND2/ITPR3	4.3221921282496
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	39/1360	142/9376	1.89345484672742	DDB1/ANAPC5/BIRC6/CDC34/ITCH/UBE2I/UBE2J1/UBE2N/UBR5/UBE2D1/RNF7/FBXW7/UBE2H/UBE2G1/BIRC2/HERC1/ELOC/ANAPC15/PIAS2/CDC26/CUL3/SIAH1/CBL/MDM2/UBA6/UBE2B/PIAS4/DDB2/RPS27A/ANAPC1/UBE2A/SMURF2/UBE2O/VHL/SOCS1/TRIM37/UBC/MAP3K1/FBXO2	4.41873629653613
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	53/1360	214/9376	1.70742166025289	DDB1/PXN/IRF3/GNG10/HLA-F/TAP2/GNAI3/RNF7/SAMHD1/ATM/MYD88/AP1G1/ITPR2/PAK2/AP1S2/PAK1/ELOC/PIK3CB/AP1S1/LIMK2/TBK1/TRIM5/ITPR1/NFKBIA/DCAF1/NRAS/KRAS/IKBKB/MAPK13/PPP3CA/PPP3R1/TRAF5/PAK4/BAX/BCL2/GNB4/CASP3/CYCS/APOBEC3C/NFATC3/BID/PIK3R3/CHEK1/MAPK8/B2M/GNG5/TRAF2/PIK3CD/CGAS/AP1G2/PTK2B/ITPR3/NFKB1	4.31187670723605
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	31/1360	105/9376	2.03540616246499	CALCOCO2/TBC1D15/USP8/RABGEF1/RRAS2/ATF4/RAB5A/EIF2AK3/CCZ1/FOXO3/TBK1/TP53/SIAH1/RHOT1/USP15/NRAS/KRAS/MFN1/GABARAPL1/ARIH1/RPS27A/TFEB/SMURF2/HIF1A/TOMM40L/MAP1LC3B2/UBC/MAPK8/PGAM5/TRAF2/CCZ1B	4.39458979204369
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	31/1360	105/9376	2.03540616246499	IRF9/NFKB2/RELB/RRAS2/ITPR2/PAK1/PIK3CB/ITPR1/NFKBIA/MDM2/NRAS/KRAS/BCL10/IKBKB/MAPK13/PPP3CA/PPP3R1/CYLD/BCL3/EGR2/MALT1/NFATC3/PIK3R3/MAPK8/PIK3CD/LSP1/PLK3/SYK/PYCARD/ITPR3/NFKB1	4.39458979204369
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1360	87/9376	2.1395537525355	GRB2/SOS2/TGFB1/RALA/SMAD3/PIK3CB/TP53/MYC/NRAS/KRAS/AXIN1/DDB2/BAX/BCL2/CASP3/CYCS/CDKN1A/PIK3R3/AXIN2/MAPK8/BRAF/MSH6/BCL2L11/PIK3CD/RALGDS/AREG/EREG	4.3983136732488
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	26/1360	83/9376	2.15960311835578	PHF1/SUZ12/CREBBP/RYBP/EP300/KDM2A/YAF2/CBX4/UBE2D1/USP16/OGT/TFDP1/LCOR/HDAC1/ASXL1/AEBP2/BCORL1/MBD6/EED/CBX8/BCOR/MTF2/EPOP/KDM2B/SFMBT1/TEX10	4.37065664777721
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	41/1360	157/9376	1.80037467216186	PTEN/CXCL8/PPP1CA/CAPN2/TGFB1/HLA-F/ATM/RRAS2/ITPR2/SMAD3/PPP1CB/HUS1/VDAC2/PIK3CB/TSC1/IL1A/FOXO3/TRPM7/TP53/SIRT1/MYC/ITPR1/MDM2/HIPK1/NRAS/KRAS/MAPK13/LIN54/PPP3CA/PPP3R1/MRE11/CDKN1A/NFATC3/SLC25A5/PIK3R3/ETS1/CDKN2B/CHEK1/PIK3CD/ITPR3/NFKB1	4.16559932009668
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/1360	157/9376	1.80037467216186	ADIPOR2/RXRA/NDUFA7/MAP3K11/CXCL8/NDUFA10/ITCH/UQCRFS1/NDUFA2/TGFB1/NDUFB5/NDUFA12/ATF4/COX5A/NDUFA9/PIK3CB/MLX/EIF2AK3/IL1A/ERN1/IKBKB/MAPK13/DDIT3/BAX/CASP3/CYCS/COX7A2/UQCRH/BID/PIK3R3/CEBPA/MAPK8/TRAF2/PRKAG2/IL6R/BCL2L11/PIK3CD/UQCRB/NR1H3/CDC42/NFKB1	4.16559932009668
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1360	77/9376	2.14881588999236	CTBP1/GRB2/SOS2/TGFB1/RUNX1/SMAD3/PIK3CB/HDAC1/TP53/CBL/MYC/NFKBIA/MDM2/NRAS/KRAS/IKBKB/DDB2/BAX/CDKN1A/PIK3R3/STAT5A/BRAF/PIK3CD/NFKB1	4.16921134424508
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	61/1360	268/9376	1.56918349429324	SLC39A1/NDUFA7/PSMD14/NDUFA10/PSMA6/UBE2J1/UQCRFS1/NDUFA2/PSMD11/PSMD9/PSMA2/NDUFB5/GNAI3/NDUFA12/ATP5F1C/PSMD12/ATF4/UBE2G1/MT-ATP8/ITPR2/COX5A/PSMA4/NDUFA9/PSMA5/VDAC2/EIF2AK3/TP53/ERN1/CAMK2G/ITPR1/MFN1/DDIT3/RPS27A/BAX/MT-ND6/GPR37/CASP3/CYCS/COX7A2/UQCRH/MT-ATP6/SLC25A5/APAF1/SLC39A4/GNAL/MT-ND3/MT-ND4L/TUBA1B/SEM1/ATP5MC2/UBC/MAPK8/PPIF/TUBB2A/LRRK2/TUBA1C/SOD1/MT-ND4/UQCRB/MT-ND2/ITPR3	3.8938966607225
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	31/1360	112/9376	1.90819327731092	IFNGR1/TGFB1/HSPA1A/GNAI3/MYD88/LAMA5/BIRC2/JAK1/IFNGR2/HLA-DRB1/NFKBIA/IKBKB/MAPK13/HSPA1L/BCL2/CASP3/ALOX5/CYCS/HLA-DPA1/HLA-DPB1/LAMB3/HLA-DRB5/SOCS1/JAK2/HLA-DQB1/MAPK8/PPIF/HLA-DMA/HLA-DQA2/HSPA1B/NFKB1	3.98257771328508
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	27/1360	93/9376	2.00151802656547	FN1/RXRA/PTEN/LAMA5/BIRC2/PIK3CB/TP53/MYC/NFKBIA/IKBKB/DDB2/TRAF5/BAX/BCL2/CASP3/CYCS/CDKN1A/CKS1B/LAMB3/APAF1/PIK3R3/CKS2/CDKN2B/COL4A2/TRAF2/PIK3CD/NFKB1	3.99790350722895
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	40/1360	158/9376	1.74534623976173	ANAPC5/CREBBP/NIPBL/SMC3/EP300/SMC1A/TGFB1/PPP2R5C/WAPL/ATM/STAG2/YWHAH/RAD21/BUB3/SMAD3/CDK7/TFDP1/ANAPC15/HDAC1/CDKN2C/TFDP2/CDC26/TP53/CCNH/MYC/MDM2/PCNA/ORC4/ANAPC1/CDKN1A/PPP2R5A/MCM3/ORC2/ESCO1/HDAC8/CDKN2B/CHEK1/MCM7/MCM4/PTTG1	3.89174606098066
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	45/1360	187/9376	1.65901226800881	HSP90AA1/PKN2/CXCL8/IRF3/ATG12/SUGT1/IRF9/HSP90AB1/IRF7/MYD88/ITPR2/BIRC2/VDAC2/JAK1/TBK1/TRPM7/IFNAR2/ITPR1/NFKBIA/CASP4/IKBKB/MFN1/MAPK13/CARD8/TRAF5/GABARAPL1/BCL2/PANX1/GBP3/NLRP1/CYBA/NAMPT/MAP1LC3B2/MAPK8/TICAM1/RIPK2/NAIP/TRAF2/TRPV2/TRPM2/CAMP/PLCB2/PYCARD/ITPR3/NFKB1	3.74935372542834
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	56/1360	248/9376	1.55673624288425	HSP90AA1/DYNC1LI1/DNM2/RHOG/ARPC4/CXCL8/DYNLL2/KPNA4/ACBD3/RAB9A/HSP90AB1/GCC2/RALA/MYD88/ARF6/BIRC2/RAB5A/PIK3C3/PAK1/PIK3CB/CYTH2/DYNC1H1/ACTR3/ARPC5L/DYNLT1/MYO6/ARPC5/MYC/NFKBIA/CASP4/STX10/ARPC1B/IKBKB/MAPK13/FBXO22/RPS3/MAP2K4/BAX/BCL2/CASP3/CYCS/FHOD1/TNFSF10/TUBA1B/MAPK8/RIPK2/TNFRSF10B/TUBB2A/NAIP/TRAF2/CYTH1/PIK3CD/TUBA1C/CDC42/PYCARD/NFKB1	3.6598539696007
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	31/1360	117/9376	1.82664655605832	PBRM1/ARID1A/RSF1/SS18/EPC1/MBD2/BAZ2B/BRD7/BRD9/EPC2/SMARCB1/ZNHIT1/BCL7B/GATAD2A/CHRAC1/GATAD2B/SMARCC1/ARID1B/HDAC1/ACTR6/MTA3/INO80E/SMARCA2/TRRAP/ARID2/ACTR8/BAZ1A/YEATS4/SS18L1/ING3/MTA2	3.70601342055387
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	23/1360	78/9376	2.03288084464555	IFNGR1/TGFB1/MYD88/JAK1/IFNGR2/IL1A/HLA-DRB1/NFKBIA/MAPK13/HLA-DPA1/HLA-DPB1/HLA-DRB5/CYBA/FCGR3B/ELK1/JAK2/HLA-DQB1/FCGR1A/MARCKSL1/HLA-DMA/HLA-DQA2/NFKB1/CR1	3.77293212057161
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	34/1360	133/9376	1.76240601503759	PTEN/GRB2/CREBBP/ATG12/EP300/SOS2/TGFB1/ATM/PRMT1/SMAD3/PIK3CB/FOXO3/SIRT1/MDM2/NRAS/SOD2/KRAS/IKBKB/MAPK13/GABARAPL1/SGK3/CDKN1A/BCL6/SGK1/PIK3R3/CDKN2B/TNFSF10/MAPK8/BRAF/STK4/PRKAG2/BCL2L11/PIK3CD/PLK3	3.64738742209137
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/1360	56/9376	2.21596638655462	CXCL8/SEC22B/NFKB2/HSPA1A/MYD88/CLK4/HBS1L/NFKBIA/HSPA1L/CLK1/CASP3/CYCS/APAF1/NAIP/HSPA1B/PYCARD/NFKB1/CR1	3.75909988018848
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	22/1360	75/9376	2.02227450980392	PTEN/ATM/CCNG1/TP53/SIAH1/PERP/MDM2/MDM4/DDB2/BAX/BCL2/CASP3/CYCS/CDKN1A/BID/PPM1D/APAF1/SESN1/CHEK1/PPP1R13L/TNFRSF10B/PIDD1	3.66108303951167
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	31/1360	120/9376	1.78098039215686	GRB2/RAPGEF1/SOS2/ATF4/PIK3CB/RPS6KA3/FOXO3/TP53/CAMK2G/NFKBIA/NRAS/KRAS/IKBKB/MAPK13/NFKBIE/BAX/BCL2/GAB1/PIK3R3/BEX3/SH2B2/IRAK3/SORT1/MAPK8/BRAF/RIPK2/MAP3K1/PIK3CD/ARHGDIB/CDC42/NFKB1	3.54646206288641
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	35/1360	142/9376	1.69925434962717	JUND/GRB2/IFNGR1/TGFB1/IRF9/NFKB2/RELB/FHL2/ITPR2/PIK3CB/JAK1/IFNGR2/IL1A/IFNAR2/ITPR1/NFKBIA/IKBKB/MAPK13/PPP3CA/PPP3R1/CYLD/SOCS1/PIK3R3/CYBA/FCGR3B/MAPK8/TRAF2/FCGR1A/PIK3CD/LILRB4/ACP5/TYROBP/SYK/ITPR3/NFKB1	3.45828397095372
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/1360	44/9376	2.35026737967914	GTF2H1/TAF7/TAF13/MNAT1/TAF1/GTF2A2/CDK7/TBPL1/CCNH/GTF2F2/TAF3/GTF2B/TAF5L/TBP/TAF8	3.69772821588672
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	24/1360	86/9376	1.92393980848153	GRB2/SOS2/NCK2/PAK2/PAK1/PIK3CB/CBL/MYC/CAMK2G/NRAS/KRAS/MAP2K4/PAK4/HBEGF/GAB1/CDKN1A/PIK3R3/STAT5A/ELK1/MAPK8/BRAF/PIK3CD/AREG/EREG	3.54536771909909
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	27/1360	101/9376	1.84298194525335	FN1/CXCL8/TGFB1/SMAD3/PIK3CB/IL1A/NRAS/KRAS/PIM1/MAPK13/BAX/BCL2/CASP3/PIK3R3/STAT5A/JAK2/ICAM1/VCAM1/PRKCZ/AGTR1/MAPK8/THBD/COL4A2/PIK3CD/PLCB2/CDC42/NFKB1	3.50831224283709
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	65/1360	308/9376	1.45492742551566	POLR2A/NDUFA7/PSMD14/POLR2F/CREBBP/NDUFA10/PSMA6/REST/UQCRFS1/EP300/NDUFA2/HIP1/PSMD11/PSMD9/PSMA2/NDUFB5/NDUFA12/ATP5F1C/POLR2G/PSMD12/MT-ATP8/COX5A/PSMA4/RCOR1/NDUFA9/PSMA5/PIK3C3/VDAC2/HDAC1/SIN3A/TP53/ERN1/NRBF2/TBPL1/ITPR1/SOD2/IFT57/BAX/MT-ND6/ATG14/CASP3/CYCS/COX7A2/UQCRH/MT-ATP6/SLC25A5/APAF1/MT-ND3/MT-ND4L/TBP/ATG2A/TUBA1B/SEM1/ATP5MC2/MAPK8/DNALI1/PPIF/TUBB2A/TRAF2/TUBA1C/SOD1/MT-ND4/UQCRB/MT-ND2/PLCB2	3.34378203333991
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	59/1360	275/9376	1.47910160427807	NDUFA7/PSMD14/NDUFA10/PSMA6/UQCRFS1/NDUFA2/PSMD11/PSMD9/PSMA2/NDUFB5/HSPA1A/NDUFA12/ATP5F1C/PSMD12/ATF4/MT-ATP8/ITPR2/COX5A/PSMA4/NDUFA9/PSMA5/VDAC2/PIK3CB/EIF2AK3/IL1A/ITPR1/MAPK13/PPP3CA/PPP3R1/HSPA1L/DDIT3/BAX/MT-ND6/CASP3/CYCS/COX7A2/UQCRH/MT-ATP6/SLC25A5/APAF1/MT-ND3/PIK3R3/MT-ND4L/CYBA/TUBA1B/SEM1/ATP5MC2/MAPK8/PPIF/TUBB2A/NOTCH1/PIK3CD/TUBA1C/SOD1/MT-ND4/UQCRB/MT-ND2/HSPA1B/ITPR3	3.32143419831329
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	34/1360	138/9376	1.69855072463768	FN1/PKN2/RHOG/ARPC4/CXCL8/PXN/IRF3/MYD88/ROCK1/PIP5K1A/ARF6/PIK3CB/RPS6KA3/ACTR3/ARPC5L/TBK1/ARPC5/NFKBIA/ARPC1B/IKBKB/MAPK13/MAP2K4/ARHGEF1/NFATC3/PIK3R3/MAPK8/TICAM1/TRAF2/PIK3CD/PIP5K1B/PTK2B/CDC42/PYCARD/NFKB1	3.40505985042612
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	21/1360	73/9376	1.98323932312651	SUPT4H1/CREBBP/FURIN/EP300/RANBP2/ELL/AFF4/CCNT1/SAMHD1/SUPT5H/SMARCB1/NELFCD/PSIP1/MX2/TRIM5/ELL2/KAT2B/MX1/APOBEC3C/CHMP6/SERINC5	3.47364471657699
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	22/1360	78/9376	1.94449472096531	PTEN/PIKFYVE/PIP5K1A/IMPA2/PPIP5K2/PIK3C3/PIK3CB/INPP1/INPP4A/IMPA1/INPP5F/MTMR14/PIP4K2A/MTMR4/SYNJ2/ISYNA1/MTMR1/PIP4K2C/PIK3CD/PI4K2B/PIP5K1B/PLCB2	3.45007315114185
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	18/1360	59/9376	2.10329012961117	PTEN/GRB2/SOS2/PIK3CB/FOXO3/TP53/MYC/NRAS/KRAS/AXIN1/DDB2/BAX/CDKN1A/PIK3R3/ELK1/AXIN2/BRAF/PIK3CD	3.5014983743881
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1360	93/9376	1.85325743200506	IFNGR1/JAK1/IFNGR2/IL4R/HLA-DRB1/NFKBIA/IKBKB/MAPK13/PPP3CA/PPP3R1/NFKBIE/NOTCH2/NFATC3/HLA-DPA1/HLA-DPB1/HLA-DRB5/STAT5A/JAK2/HLA-DQB1/MAPK8/NOTCH1/JAK3/HLA-DMA/HLA-DQA2/NFKB1	3.4060703746696
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	14/1360	41/9376	2.35408895265423	ATM/RPA2/RPA3/TOPBP1/MUS81/RBBP8/TOP3A/MRE11/UIMC1/POLD3/BARD1/RAD51C/SEM1/RAD51D	3.57897117210912
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	50/1360	227/9376	1.51852811609225	GRB2/CXCL8/PXN/IRF3/GNA13/GNG10/SOS2/HLA-F/TAP2/GNAI3/ROCK1/ATF4/ITPR2/PIK3CB/JAK1/TSC1/TBK1/TP53/MYC/ITPR1/NFKBIA/MDM2/NRAS/KRAS/IKBKB/MAPK13/PPP3CA/PPP3R1/TRAF5/BAX/GNB4/CASP3/CYCS/CDKN1A/ARHGEF1/NFATC3/BID/PIK3R3/ELK1/CCL3L1/B2M/GNG5/TRAF2/IL6R/PIK3CD/CGAS/PLCB2/PTK2B/ITPR3/NFKB1	3.25742678379417
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1360	156/9376	1.63514328808446	RXRA/GRB2/PPP2R2A/IRF3/SOS2/IRF9/IRF7/YWHAH/PIK3CB/JAK1/PPP2R2D/CFLAR/TBK1/TP53/MX2/MYC/IFNAR2/NFKBIA/NRAS/KRAS/IKBKB/BAX/CASP3/MX1/CYCS/CDKN1A/BID/APAF1/PIK3R3/TICAM1/BRAF/TRAF2/RSAD2/PIK3CD/NR1H3/CLDN7/NFKB1	3.29491935750615
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	54/1360	250/9376	1.48912941176471	GUSB/TCIRG1/AP3S1/RRAGC/AGA/CLN8/GM2A/AP3B1/PIKFYVE/ENTPD4/ATP6V0D1/SPG11/SLC17A5/AP1G1/ATP6V1B2/PPT1/OSBPL2/NEU1/DMXL2/AP1S2/AP5Z1/VAMP7/AP1S1/ATP6V0B/LAMTOR4/CTSH/BLOC1S4/BLOC1S2/GLA/BORCS8/AP3M2/GNPTAB/ASAH1/GGA2/CTSF/SLC15A3/BLOC1S5/SLC2A6/BORCS5/TFEB/NAGPA/DTNBP1/FUCA1/ROGDI/SORT1/LITAF/ATP6V0A2/SLC29A3/RRAGB/MFSD8/ABCB9/CTSW/ACP5/AP1G2	3.22871557233675
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	15/1360	46/9376	2.24808184143223	PSMD14/PSMA6/PSMD11/PSMD9/PSMA2/PSMD12/PSMB10/PSMA4/PSMA5/PSMB8/PSME2/PSME4/PSMB9/SEM1/POMP	3.49508221954157
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	20/1360	71/9376	1.94200497100249	CXCL8/LYN/TCIRG1/ATP6V0D1/ATP6V1B2/PAK1/GIT1/ATP6V0B/NFKBIA/IKBKB/MAPK13/MAP2K4/HBEGF/CASP3/JAM2/ADAM17/MAPK8/ATP6V0A2/CDC42/NFKB1	3.2817116465961
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	34/1360	144/9376	1.62777777777778	PSMD14/PSMA6/ATXN2/AFG3L2/PSMD11/PSMD9/PSMA2/PSMD12/ITPR2/PSMA4/ATXN2L/PSMA5/PIK3C3/VDAC2/PIK3CB/ERN1/NRBF2/TBPL1/ITPR1/GTF2B/ATG14/CYCS/SLC25A5/PIK3R3/OMA1/TBP/ATG2A/SEM1/MAPK8/PPIF/TRAF2/PIK3CD/PLCB2/ITPR3	3.12691103149431
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	18/1360	62/9376	2.00151802656547	CTBP1/CIR1/CREBBP/ITCH/EP300/SNW1/SPEN/HDAC1/TLE1/NUMB/NOTCH2/KAT2B/DTX2/TLE4/ADAM17/HES1/NOTCH1/DTX4	3.25883773694954
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	44/1360	200/9376	1.51670588235294	ARPC4/CXCL8/GNA13/SEC24A/NCK2/MYO1E/ARHGEF2/MYD88/ROCK1/ARF6/PAK2/PAK1/CYTH2/ACTR3/ARPC5L/MYO6/ARPC5/NFKBIA/CASP4/ARPC1B/IKBKB/MAPK13/RPS3/BAX/MYH10/CASP3/CYCS/ARHGEF1/TNFSF10/TUBA1B/MAPK8/NCL/TNFRSF10B/EZR/TUBB2A/NAIP/TRAF2/CYTH1/BAIAP2L1/TUBA1C/CDC42/PYCARD/CLDN7/NFKB1	3.04234134330792
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	18/1360	63/9376	1.96974789915966	KMT2C/ALDH9A1/NSD1/KMT2B/PHYKPL/EHMT2/KMT5A/PRDM2/EHMT1/KMT2D/NSD3/SETD1B/SETDB1/KMT2E/SMYD2/ACAT2/ALDH2/DOT1L	3.18097721856256
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1360	68/9376	1.92629757785467	GRB2/SOS2/RUNX1/PIK3CB/MYC/NRAS/KRAS/IKBKB/PIM1/RARA/PIK3R3/STAT5A/CEBPA/BRAF/FCGR1A/PIK3CD/JUP/BCL2A1/NFKB1	3.1575703520004
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/1360	125/9376	1.65458823529412	PTEN/ORMDL1/PPP2R2A/GNA13/PPP2R5C/GNAI3/ROCK1/PIK3CB/PPP2R2D/NSMAF/TP53/CERS5/ASAH1/NRAS/KRAS/MAPK13/BAX/BCL2/SMPD2/PPP2R5A/BID/PIK3R3/PRKCZ/MAPK8/SGMS2/TRAF2/DEGS2/PIK3CD/PLCB2/NFKB1	3.03462547813347
Human Diseases	Infectious disease: viral	hsa05162	Measles	32/1360	136/9376	1.62214532871972	IRF3/IRF9/RAB9A/HSPA1A/IFIH1/IRF7/MYD88/EIF3H/PIK3CB/JAK1/IL1A/TBK1/TP53/MX2/IFNAR2/NFKBIA/IKBKB/HSPA1L/BAX/BCL2/CASP3/MX1/CYCS/BID/APAF1/PIK3R3/STAT5A/MAPK8/JAK3/PIK3CD/HSPA1B/NFKB1	3.01024297350399
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	26/1360	105/9376	1.70711484593838	CXCL8/LYN/UBE2I/NFKB2/RELB/ATM/MYD88/BIRC2/CFLAR/NFKBIA/BCL10/IKBKB/PIAS4/CYLD/TRAF5/BCL2/MALT1/PPP1R13L/ICAM1/VCAM1/TICAM1/TRAF2/PIDD1/BCL2A1/SYK/NFKB1	3.00121806921196
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	44/1360	204/9376	1.48696655132641	FN1/GPC1/GRB2/PXN/PPP1CA/SOS2/TGFB1/PPP1R12A/ROCK1/RRAS2/ITPR2/IQGAP1/PPP1CB/PAK1/PIK3CB/TP53/PDCD4/CBL/MYC/CAMK2G/ITPR1/MDM2/NRAS/KRAS/MAPK13/SDC4/HBEGF/CASP3/GAB1/HIF1A/CDKN1A/ARHGEF1/PIK3R3/SDC1/ELK1/BRAF/DDX5/EZR/IGF2/PIK3CD/PPP1R12B/CDC42/PLAUR/ITPR3	2.89639927635306
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	8/1360	20/9376	2.75764705882353	FDFT1/SC5D/MSMO1/HSD17B7/DHCR24/EBP/LBR/SQLE	3.24099082181207
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	43/1360	205/9376	1.44608321377331	PTEN/NDUFA7/PPP1CA/NDUFA10/UQCRFS1/NDUFA2/TGFB1/NDUFB5/NDUFA12/ATP5F1C/MT-ATP8/COX5A/NDUFA9/SMAD3/PPP1CB/VDAC2/MPC2/PIK3CB/PDHA1/CAMK2G/MPC1/MAPK13/MT-ND6/COX7A2/UQCRH/MT-ATP6/SLC25A5/MT-ND3/PIK3R3/MT-ND4L/CYBA/ATP5MC2/PRKCZ/AGTR1/MAPK8/PPIF/PIK3CD/MT-ND4/UQCRB/MT-ND2/PDK4/PLCB2/NFKB1	2.65987178635436
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	89/1360	480/9376	1.27828431372549	NDUFA7/PSMD14/NDUFA10/PSMA6/ATXN2/UBE2J1/UQCRFS1/CAPN2/NDUFA2/HIP1/PSMD11/PSMD9/PSMA2/NDUFB5/NDUFA12/ATP5F1C/SPG11/PSMD12/ATF4/UBE2G1/MT-ATP8/ITPR2/RAB8A/COX5A/PSMA4/ATXN2L/RAB5A/NDUFA9/PSMA5/PIK3C3/VDAC2/SMCR8/EIF2AK3/IL1A/TBK1/ERN1/NRBF2/CAMK2G/ITPR1/NRAS/KRAS/MFN1/IFT57/MAPK13/PPP3CA/PPP3R1/AXIN1/DDIT3/RPS27A/BAX/MT-ND6/BCL2/ATG14/GPR37/CASP3/C9orf72/CYCS/COX7A2/UQCRH/BID/MT-ATP6/SLC25A5/APAF1/MT-ND3/MT-ND4L/TOMM40L/ATG2A/TUBA1B/SEM1/ATP5MC2/AXIN2/FRAT2/MAP1LC3B2/UBC/MAPK8/DNALI1/BRAF/PPIF/TUBB2A/TRAF2/LRRK2/TUBA1C/SOD1/MT-ND4/UQCRB/MT-ND2/PLCB2/ITPR3/NFKB1	2.57803136323452
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	28/1360	122/9376	1.58225650916104	GRB2/PPP2R2A/SOS2/PPP2R5C/NCK2/PAK2/PAK1/PIK3CB/PPP2R2D/DLG1/NFKBIA/NRAS/KRAS/BCL10/IKBKB/MAPK13/PPP3CA/PPP3R1/NFKBIE/PAK4/PPP2R5A/MALT1/NFATC3/PIK3R3/MAPK8/PIK3CD/CDC42/NFKB1	2.66628001946435
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	28/1360	122/9376	1.58225650916104	RXRA/CREBBP/MED4/EP300/MED1/MED13/ATP1A1/NCOA2/MED13L/ATP1B3/PIK3CB/HDAC1/MED17/NCOA3/SIN3A/TP53/MYC/MDM2/NRAS/KRAS/NOTCH2/KAT2B/HIF1A/PIK3R3/MED30/NOTCH1/PIK3CD/PLCB2	2.66628001946435
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	36/1360	168/9376	1.47731092436975	HSP90AA1/FTL/IFNGR1/CHMP5/CAPN2/IRF9/HSP90AB1/BIRC2/VDAC2/JAK1/IFNGR2/IL1A/CFLAR/TRPM7/CAMK2G/IFNAR2/CYLD/TRAF5/BAX/BCL2/CHMP6/BID/USP21/SLC25A5/STAT5A/TNFSF10/JAK2/MAPK8/TICAM1/CHMP1B/TNFRSF10B/PGAM5/TRAF2/JAK3/SPATA2/PYCARD	2.57128133923741
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1360	388/9376	1.29708914493633	SLC39A1/NDUFA7/PSMD14/NDUFA10/PSMA6/UQCRFS1/CAPN2/NDUFA2/PSMD11/PSMD9/PSMA2/NDUFB5/NDUFA12/ATP5F1C/PSMD12/ATF4/MT-ATP8/ITPR2/COX5A/PSMA4/BACE2/NDUFA9/PSMA5/PIK3C3/VDAC2/PIK3CB/EIF2AK3/IL1A/ERN1/NRBF2/ITPR1/NRAS/KRAS/IKBKB/PPP3CA/PPP3R1/AXIN1/DDIT3/MT-ND6/ATG14/CASP3/CYCS/COX7A2/UQCRH/BID/MT-ATP6/SLC25A5/APAF1/SLC39A4/MT-ND3/PIK3R3/MME/MT-ND4L/ADAM17/ATG2A/TUBA1B/SEM1/ATP5MC2/AXIN2/FRAT2/MAPK8/BRAF/PPIF/TUBB2A/TRAF2/PIK3CD/TUBA1C/MT-ND4/UQCRB/MT-ND2/PLCB2/ITPR3/NFKB1	2.46176930812308
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	46/1360	227/9376	1.39704586680487	PTEN/NDUFA7/GRB2/ACP1/NDUFA10/UQCRFS1/SOS2/NDUFA2/NDUFB5/NDUFA12/ATP5F1C/PRKD3/MT-ATP8/COX5A/NDUFA9/VDAC2/PIK3CB/FOXO3/NFKBIA/NRAS/SOD2/KRAS/IKBKB/MAPK13/MAP2K4/MT-ND6/PRKD2/COX7A2/UQCRH/HIF1A/MT-ATP6/SLC25A5/MT-ND3/PIK3R3/MT-ND4L/CYBA/ATP5MC2/MAPK8/BRAF/PPIF/PIK3CD/SOD1/MT-ND4/UQCRB/MT-ND2/NFKB1	2.49426752530206
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/1360	36/9376	2.10653594771242	POLE4/RPA2/RPA3/PCNA/RNASEH2B/MCM3/POLD3/PRIM2/MCM7/MCM4/RFC2	2.73980451916723
Genetic Information Processing	Translation	hsa03010	Ribosome	45/1360	222/9376	1.39745627980922	RPLP1/RPL34/RPL39/MRPL52/MRPL15/MRPL18/MRPS18C/MRPS30/RPL30/RPS23/RSL24D1/RPS15A/RPS12/RPS3A/MRPS11/MRPL23/RPL22L1/MRPL44/RPL37/RPS14/RPS24/RPS3/RPS27A/RPS19/RPL32/RPL26/RPL14/RPL41/RPS4X/RPL10/RPS13/FAU/RPS28/RPS7/RPS21/RPL9/RPLP2/RPL21/RPL23/RPS11/RPL24/RPS29/RPL19/RPS20/RPL27A	2.46851991074557
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	58/1360	300/9376	1.33286274509804	JUND/MAP3K11/GRB2/SOS2/TGFB1/FLT1/NFKB2/HSPA1A/MAP3K2/RELB/MYD88/RRAS2/ATF4/PAK2/PPM1B/PAK1/DUSP16/RPS6KA3/TAOK3/IL1A/RASA2/TP53/MYC/NRAS/KRAS/IKBKB/MAPK13/MKNK2/PPP3CA/PPP3R1/MAP2K4/HSPA1L/DDIT3/MAPKAPK3/CASP3/DUSP8/RASA1/NFATC3/FLT3LG/MAPKAPK5/MAP4K2/ELK1/TEK/MAPK8/BRAF/RAPGEF2/STK4/MAP3K1/TRAF2/IGF2/MAP3K12/STMN1/DUSP4/AREG/HSPA1B/CDC42/EREG/NFKB1	2.4135417310529
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1360	77/9376	1.70114591291062	TGFB1/RALA/SMAD3/PIK3CB/JAK1/RALBP1/TP53/KRAS/IKBKB/DDB2/BAX/CDKN1A/PIK3R3/MAPK8/BRAF/PIK3CD/RALGDS/CDC42/NFKB1	2.544555241221
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1360	32/9376	2.15441176470588	BIRC6/BIRC2/BAX/BCL2/CASP3/CYCS/BID/APAF1/MAPK8/BCL2L11	2.69429755152169
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	41/1360	201/9376	1.40626280362891	RXRA/CXCL8/SS18/FLT1/CCNT1/ATM/AFF1/BIRC2/RUNX1/HDAC1/CDKN2C/SIN3A/TP53/LDB1/MYC/MDM2/KLF3/DDB2/DDIT3/BAX/SMAD1/TCF3/RARA/CDKN1A/BCL6/LYL1/KDM6A/SS18L1/CEBPA/ASPSCR1/DDX5/MEN1/FCGR1A/LMO2/JUP/GZMB/HPGD/DOT1L/ID2/BCL2A1/NFKB1	2.39816075501841
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	30/1360	138/9376	1.49872122762148	PRKAR2A/FLOT1/GRB2/PPP1CA/RAPGEF1/SOS2/EIF4E2/FLOT2/PPP1CB/PIK3CB/TSC1/PPP1R3B/CBL/PHKG2/NRAS/SOCS2/KRAS/IKBKB/MKNK2/EIF4E/SOCS1/PIK3R3/SH2B2/ELK1/PRKCZ/MAPK8/BRAF/SOCS4/PRKAG2/PIK3CD	2.43099830668694
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	49/1360	250/9376	1.35124705882353	DNM2/ARPC4/IST1/CAPZA2/CHMP5/ITCH/SH3GLB1/SH3GL1/ARFGAP3/ACAP1/USP8/HLA-F/HSPA1A/PIP5K1A/ARF6/SH3KBP1/RAB8A/RAB5A/ARFGEF1/ZFYVE16/SMAD3/GIT1/IQSEC1/CYTH2/SMAP2/ACTR3/ARPC5L/VPS36/CBL/ARPC5/MDM2/ARPC1B/MVB12A/HSPA1L/RAB11FIP1/ARF5/WASHC2A/SMURF2/EHD1/CHMP6/GRK6/PRKCZ/CHMP1B/CYTH1/ASAP3/PIP5K1B/HSPA1B/EHD3/CDC42	2.31856196189355
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/1360	63/9376	1.75088702147526	POLR2A/DDB1/POLR2F/GTF2H1/POLE4/MNAT1/POLR2G/RPA2/CDK7/RPA3/CCNH/PCNA/DDB2/POLD3/ERCC6/RFC2	2.46306747464665
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1360	90/9376	1.60862745098039	PTEN/IFNGR1/MYD88/PIK3CB/JAK1/IFNGR2/NFKBIA/NRAS/KRAS/IKBKB/MAPK13/PPP3CA/PPP3R1/NFKBIE/HIF1A/NFATC3/PIK3R3/JAK2/TICAM1/PIK3CD/NFKB1	2.38965216235475
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1360	80/9376	1.63735294117647	PTEN/GRB2/SOS2/EIF4E2/PIK3CB/JAK1/FOXO3/NRAS/KRAS/BAX/BCL2/EIF4E/GAB1/PIK3R3/JAK2/BRAF/IL6R/BCL2L11/PIK3CD	2.358050861972
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	35/1360	170/9376	1.41937716262976	RAB8B/ARPC4/PPP2R2A/WHAMM/ARHGEF2/ROCK1/ACTN1/HSPA4/RAB8A/RUNX1/ARHGAP17/PPP2R2D/DLG1/ACTR3/ARPC5L/ACTN4/ARPC5/PCNA/ARPC1B/TJAP1/RAP2C/MYH10/JAM2/RAPGEF6/TUBA1B/PRKCZ/MAPK8/EZR/RAPGEF2/MAP3K1/PRKAG2/TUBA1C/CD1D/CDC42/CLDN7	2.27284589607635
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	46/1360	235/9376	1.34948685857322	NDUFA7/GRB2/ARID1A/NDUFA10/ACSL1/UQCRFS1/SOS2/NDUFA2/COX17/NDUFB5/NDUFA12/ATP5F1C/SMARCB1/MT-ATP8/KDM3B/COX5A/SMARCC1/NDUFA9/ARID1B/RPS6KA3/COA1/TSC1/NRAS/KRAS/COX19/SMARCA2/COX18/MAPK13/ACSL4/MT-ND6/ACSL3/KDM1A/COX7A2/CPT1A/SLC25A29/UQCRH/MT-ATP6/MT-ND3/MT-ND4L/COA7/ATP5MC2/NDUFAF7/PRKAG2/MT-ND4/UQCRB/MT-ND2	2.23482831308464
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1360	104/9376	1.52466063348416	PLPP5/DGKZ/ETNK1/LPCAT1/CHKB/LYPLA1/LPIN2/PLAAT3/CDS2/CRLS1/PGS1/GPCPD1/LPCAT3/PCYT2/LYPLA2/DGKA/DGKD/DGKE/SGMS2/PLB1/AGPAT4/CHKA/LPIN3	2.21607612862303
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1360	82/9376	1.5974175035868	HSP90AA1/HLA-F/TAP2/HSP90AB1/HSPA1A/NFYB/HSPA4/PSME2/HLA-DRB1/NFYC/HSPA1L/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/B2M/HLA-DMA/HLA-DQA2/HSPA1B	2.23799840659437
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1360	67/9376	1.64635645302897	CREBBP/PPP1CA/EP300/ATF4/ITPR2/PPP1CB/RPS6KA3/CAMK2G/ITPR1/NRAS/KRAS/PPP3CA/PPP3R1/BRAF/PLCB2/ITPR3	2.1869266318911
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1360	78/9376	1.59095022624434	FN1/DNM2/RHOG/ARPC4/PXN/CD2AP/SEPTIN6/PIK3CB/ACTR3/ARPC5L/CBL/ARPC5/ARPC1B/GAB1/PIK3R3/ARHGAP10/PIK3CD/CDC42	2.15863727342283
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1360	41/9376	1.84964131994261	CXCL8/TP53/TYMP/MYC/MDM2/NRAS/KRAS/HBEGF/CDKN1A/DAPK1/BRAF	2.24567358351666
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/1360	95/9376	1.52396284829721	CXCL8/TCIRG1/TGFB1/FLT1/ATP6V0D1/ATP6V1B2/ATP6V0B/IL1A/HLA-DRB1/TNFSF13/HLA-DPA1/HLA-DPB1/HLA-DRB5/CCL3L1/TEK/ICAM1/HLA-DQB1/ATP6V0A2/HLA-DMA/HLA-DQA2/ACP5	2.11417605026957
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	17/1360	73/9376	1.60547945205479	RXRA/GRB2/SOS2/PIK3CB/FOXO3/TP53/NRAS/KRAS/DDB2/BAX/CDKN1A/PIK3R3/STAT5A/BRAF/STK4/JAK3/PIK3CD	2.1390728077659
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	20/1360	90/9376	1.53202614379085	ADIPOR2/EIF4E2/ATF4/PIK3CB/TSC1/EHMT2/FOXO3/TP53/EHMT1/SIRT1/NRAS/SOD2/KRAS/BAX/EIF4E/PIK3R3/SESN1/PRKAG2/PIK3CD/NFKB1	2.08889267628519
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1360	42/9376	1.80560224089636	FTL/ACSL1/VDAC2/SAT1/TP53/SLC3A2/LPCAT3/ACSL4/GCLM/ACSL3/MAP1LC3B2	2.15520035862989
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	25/1360	119/9376	1.44834404349975	ITCH/ATF4/BIRC2/PIK3CB/CFLAR/FRMD8/NFKBIA/IKBKB/MAPK13/MAP2K4/CYLD/TRAF5/CASP3/BCL3/IL18R1/PIK3R3/ADAM17/ICAM1/VCAM1/MAPK8/PGAM5/TRAF2/PIK3CD/CASP10/NFKB1	2.02733720859387
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1360	37/9376	1.86327503974563	RXRA/TP53/MYC/NRAS/KRAS/DDB2/BAX/CDKN1A/TPM3/BRAF	2.16708575111866
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	20/1360	91/9376	1.51519069166128	GRB2/LYN/SOS2/PIK3CB/NFKBIA/NRAS/KRAS/BCL10/IKBKB/PPP3CA/PPP3R1/NFKBIE/MALT1/NFATC3/PIK3R3/PIK3CD/LILRB4/IFITM1/SYK/NFKB1	2.03410790672052
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	30/1360	149/9376	1.38807737860245	DNM2/GRB2/CXCL8/GNA13/DGKZ/SOS2/RALA/PIP5K1A/RRAS2/ARF6/PIK3CB/CYTH2/TSC1/NRAS/KRAS/GAB1/LPAR6/DGKA/PIK3R3/DGKD/DGKE/AGTR1/CYTH1/PIK3CD/AGPAT4/RALGDS/PIP5K1B/PLCB2/PTK2B/SYK	1.96678750278663
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1360	103/9376	1.47252998286693	PPP2R2A/CXCL8/IFNGR1/TGFB1/GNAI3/MYD88/PIK3CB/IFNGR2/PPP2R2D/CFLAR/NFKBIA/IKBKB/MAPK13/MAP2K4/GNAL/PIK3R3/CCL3L1/MAPK8/TICAM1/PIK3CD/PLCB2/NFKB1	1.98615935897229
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	28/1360	138/9376	1.39880647911338	NDUFA7/NDUFA10/TCIRG1/UQCRFS1/NDUFA2/COX17/NDUFB5/NDUFA12/ATP5F1C/ATP6V0D1/ATP6V1B2/MT-ATP8/COX5A/NDUFA9/ATP6V0B/MT-ND6/CYCS/COX7A2/PPA1/UQCRH/MT-ATP6/MT-ND3/MT-ND4L/ATP5MC2/ATP6V0A2/MT-ND4/UQCRB/MT-ND2	1.94396753481735
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1360	59/9376	1.63589232303091	CDA/ENTPD4/NME6/ASMTL/TYMP/NT5C3A/DCTPP1/UCK2/CDADC1/NME7/DCK/UPP1/ENTPD5/CTPS1	2.01812367900301
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	21/1360	98/9376	1.47731092436975	DNM2/ARPC4/LYN/PIP5K1A/ARF6/PAK1/PIK3CB/LIMK2/ACTR3/ARPC5L/ARPC5/ARPC1B/PIK3R3/FCGR3B/FCGR1A/PIK3CD/MARCKSL1/ASAP3/PIP5K1B/SYK/CDC42	1.95642618215596
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	34/1360	174/9376	1.34712643678161	HSP90AA1/EDEM1/BAG1/EDEM2/UBE2J1/CAPN2/SEC24A/HSP90AB1/HSPA1A/UBE2D1/DNAJA2/DNAJB11/ATF4/UBE2G1/SEC23B/UBXN4/DDOST/EIF2AK3/ERN1/ERP29/ERO1B/NGLY1/HSPA1L/DDIT3/BAX/BCL2/FBXO6/MAPK8/TRAF2/HERPUD1/SVIP/FBXO2/HSPA1B/DNAJA1	1.90369530199444
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	8/1360	28/9376	1.96974789915966	TECR/ACAA2/ELOVL5/PPT1/HACD2/ACOT7/MBLAC2/HACD1	2.11667777307068
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	13/1360	54/9376	1.65969498910675	USP1/CENPX/RPA2/RPA3/MUS81/REV1/TOP3A/CENPS/SLX4/RAD51C/HES1/EME2/RMI1	2.00245033757492
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1360	99/9376	1.46238859180036	GRB2/MED1/SOS2/PIK3CB/CDKN2C/NCOA3/TP53/MDM2/NRAS/KRAS/MAPK13/BAX/HBEGF/NOTCH2/BCL2/CDKN1A/PIK3R3/MAPK8/BRAF/NOTCH1/PIK3CD	1.90500959578287
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/1360	99/9376	1.46238859180036	GRB2/DGKZ/SOS2/CHKB/LYPLA1/PIP5K1A/PIK3CB/TSC1/NRAS/KRAS/GPCPD1/HIF1A/DGKA/PIK3R3/DGKD/DGKE/MAPK8/PIK3CD/CHKA/RALGDS/PIP5K1B	1.90500959578287
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1360	71/9376	1.55360397680199	GRB2/SOS2/PIK3CB/FOXO3/NRAS/SOCS2/KRAS/MAPK13/SOCS1/PIK3R3/STAT5A/JAK2/MAPK8/SOCS4/PIK3CD/NFKB1	1.92861892898462
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1360	44/9376	1.72352941176471	POLE4/TDG/MBD4/PCNA/LIG3/POLG2/POLD3/XRCC1/PARP2/POLB/RFC2	1.98139654498801
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/1360	66/9376	1.5668449197861	IFNGR1/TGFB1/SMAD3/IFNGR2/IL4R/IL1A/HLA-DRB1/IL18R1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2/NFKB1	1.90343313010939
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1360	106/9376	1.43085460599334	HSP90AA1/PTEN/GRB2/CREBBP/EP300/SOS2/HSP90AB1/ATF4/PIK3CB/TP53/NFKBIA/MDM2/NRAS/KRAS/IKBKB/BCL2/CDKN1A/PIK3R3/BRAF/PIK3CD/SLC19A1/NFKB1	1.83746909703756
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1360	62/9376	1.55673624288425	HSPA1A/PIK3CB/HDAC1/FOXO3/SIRT1/NRAS/SOD2/KRAS/HSPA1L/PIK3R3/PRKAG2/PIK3CD/SOD1/HSPA1B	1.81156307696286
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	6/1360	20/9376	2.06823529411765	UGP2/CMAS/NANS/NPL/UAP1/CYB5R2	1.96975881272113
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/1360	30/9376	1.83843137254902	GART/IKBKB/SHMT1/DHFR/MTHFR/ABCG2/SLC19A1/NFKB1	1.89448642459006
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	18/1360	85/9376	1.45993079584775	GMPS/CDA/ADA2/ENTPD4/DGUOK/NME6/ASMTL/ADK/TYMP/NT5C3A/DCTPP1/UCK2/PNP/NME7/DCK/UPP1/ENTPD5/CTPS1	1.7544740974188
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	26/1360	133/9376	1.34772224679345	GRB2/IFNGR1/SOS2/PAK1/PIK3CB/IFNGR2/IFNAR2/NRAS/KRAS/PPP3CA/PPP3R1/CASP3/BID/PIK3R3/TNFSF10/FCGR3B/ICAM1/ULBP2/BRAF/TNFRSF10B/SH3BP2/PIK3CD/GZMB/TYROBP/PTK2B/SYK	1.66352012486845
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/1360	139/9376	1.33914515446466	HSP90AA1/GRB2/SOS2/HSP90AB1/HSPA1A/FKBP4/GNAI3/KRT18/NCOA2/ATF4/ITPR2/PIK3CB/NCOA3/KRT10/ITPR1/NRAS/KRAS/POMC/HSPA1L/HBEGF/BCL2/RARA/PIK3R3/PIK3CD/HSPA1B/PLCB2/ITPR3	1.65921926991649
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1360	75/9376	1.47074509803922	ATM/SLC31A1/BIRC2/PIK3CB/TP53/MDM2/BAX/BCL2/CASP3/CYCS/CDKN1A/BID/APAF1/PIK3R3/MSH6/PIK3CD	1.68588464041346
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1360	110/9376	1.37882352941176	CREBBP/IFNGR1/EP300/EIF4E2/FLT1/ELOC/PIK3CB/IFNGR2/PDHA1/CAMK2G/MKNK2/BCL2/EIF4E/HIF1A/CDKN1A/VHL/PIK3R3/TEK/IL6R/PIK3CD/EPAS1/NFKB1	1.64612715320162
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	30/1360	158/9376	1.3090096798213	PTEN/GRB2/RRAGC/SOS2/EIF4E2/CLIP1/ATP6V1B2/LPIN2/PIK3CB/RPS6KA3/FNIP1/TSC1/LAMTOR4/SLC3A2/NRAS/DDIT4/KRAS/IKBKB/SEH1L/FLCN/STRADA/EIF4E/GRB10/RICTOR/SGK1/PIK3R3/BRAF/RRAGB/PIK3CD/LPIN3	1.61346115415282
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/1360	122/9376	1.35621986499518	GRB2/CREBBP/EP300/SOS2/GNAI3/ATF4/ITPR2/PIK3CB/ITPR1/NRAS/SOCS2/KRAS/MAPK13/MAP2K4/CSH1/SOCS1/PIK3R3/STAT5A/JAK2/MAPK8/MAP3K1/PIK3CD/PLCB2/ITPR3	1.63120874327613
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	19/1360	93/9376	1.40847564832385	GRB2/SOS2/MAP3K2/ATF4/ITPR2/CAMK2G/ITPR1/NRAS/KRAS/MAPK13/MAP2K4/HBEGF/ELK1/MAPK8/MAP3K1/PLCB2/PTK2B/CDC42/ITPR3	1.63057097699157
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	15/1360	70/9376	1.47731092436975	ADIPOR2/RXRA/ACSL1/NFKBIA/IKBKB/POMC/ACSL4/NFKBIE/ACSL3/CPT1A/JAK2/MAPK8/TRAF2/PRKAG2/NFKB1	1.65099253026882
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1360	32/9376	1.72352941176471	ATG12/ATG3/IGBP1/PIK3C3/GABARAPL1/ATG4D/ATG2A/ATG10	1.68865528069894
Human Diseases	Immune disease	hsa05310	Asthma	8/1360	32/9376	1.72352941176471	PRG2/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2	1.68865528069894
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1360	71/9376	1.45650372825186	PTEN/SCO2/PIK3CB/SLC1A5/PDHA1/TP53/MYC/TIGAR/NRAS/KRAS/GLS/HIF1A/PIK3R3/IDH2/PIK3CD	1.59034574958175
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1360	43/9376	1.60328317373461	ACAA1/ACSL1/ACAA2/ALDH9A1/ECI2/ACSL4/ACSL3/CPT1A/ACAT2/ALDH2	1.63313108599907
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1360	83/9376	1.41204819277108	GSTK1/ACAA1/ACSL1/ECI2/PEX3/SOD2/DECR2/ACSL4/PEX13/ACSL3/CROT/HACL1/MPV17L2/PXMP2/IDH2/SOD1/PXMP4	1.55304961191643
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	15/1360	72/9376	1.43627450980392	CXCL8/IRF3/ATG12/IFIH1/IRF7/TBK1/NFKBIA/IKBKB/MAPK13/CYLD/MAPK8/MAP3K1/TRAF2/CASP10/NFKB1	1.53062032041883
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1360	33/9376	1.67130124777184	USE1/SEC22B/SNAP23/STX16/STX5/STX4/VAMP7/VAMP5	1.59113668200417
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1360	44/9376	1.5668449197861	HLA-F/IL1A/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2/GZMB	1.55231362726333
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/1360	39/9376	1.59095022624434	HLA-F/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2/GZMB	1.52319591206342
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1360	23/9376	1.79846547314578	RPA2/RPA3/PCNA/POLD3/MSH6/RFC2	1.57914071205172
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1360	13/9376	2.12126696832579	MRE11/LIG4/DCLRE1C/NHEJ1	1.66628556073692
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/1360	45/9376	1.53202614379085	HLA-F/IL1A/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2/GZMB	1.47350418741391
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1360	57/9376	1.45139318885449	ACAA1/ACSL1/TECR/ACAA2/ELOVL5/PPT1/HACD2/ACSL4/ACSL3/CPT1A/HACD1/ACAT2	1.40793955974692
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/1360	94/9376	1.32015018773467	S100A8/S100A9/JUND/HSP90AA1/ANAPC5/CXCL8/HSP90AB1/IL17RA/TBK1/NFKBIA/IKBKB/MAPK13/TRAF5/CASP3/MAPK8/TRAF2/IL17RE/NFKB1	1.28491128587574
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/1360	76/9376	1.36068111455108	PTEN/GRB2/SOS2/PIK3CB/TP53/CAMK2G/MDM2/NRAS/KRAS/DDB2/BAX/CDKN1A/PIK3R3/BRAF/PIK3CD	1.30036407568485
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	30/1360	168/9376	1.23109243697479	GRB2/CREBBP/IFNGR1/EP300/SOS2/IRF9/PIK3CB/JAK1/IFNGR2/IL4R/PIAS2/PTPN2/MYC/IFNAR2/SOCS2/PIM1/PIAS4/CSH1/BCL2/LIFR/CDKN1A/SOCS1/PIK3R3/STAT5A/JAK2/SOCS4/IL6R/JAK3/PIK3CD/IL11RA	1.24489853572234
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1360	14/9376	1.96974789915966	B4GALT4/B4GALT1/B3GNT2/ST3GAL3	1.49559768756684
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	40/1360	232/9376	1.18864097363083	FN1/ARPC4/PXN/PPP1CA/GNA13/SOS2/PPP1R12A/PIKFYVE/ROCK1/PIP5K1A/ACTN1/RRAS2/PAK2/IQGAP1/PPP1CB/PAK1/PIK3CB/GIT1/LIMK2/ACTR3/ARPC5L/ACTN4/ARPC5/NRAS/ARPC1B/KRAS/ENAH/PAK4/MYH10/ARHGEF1/PIP4K2A/PIK3R3/SPATA13/BRAF/EZR/PIP4K2C/PIK3CD/PPP1R12B/PIP5K1B/CDC42	1.19836233673451
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1360	107/9376	1.28862012094557	PPP4R3B/CREBBP/EP300/PRMT1/PPP4C/ATF4/ITPR2/CRTC2/PPP4R3A/PDHA1/SIRT1/CAMK2G/ITPR1/PHKG2/PPP3CA/PPP3R1/CPT1A/PRKAG2/PLCB2/ITPR3	1.23673966620898
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	30/1360	170/9376	1.21660899653979	PTEN/PBRM1/GRB2/ARID1A/SOS2/TGFB1/BRD7/SMARCB1/SMARCC1/SMAD3/ARID1B/PIK3CB/TP53/MYC/NRAS/KRAS/SMARCA2/AXIN1/DDB2/BAX/GAB1/ARID2/CDKN1A/PIK3R3/ELK1/AXIN2/FRAT2/BRAF/IGF2/PIK3CD	1.17392865589422
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1360	60/9376	1.37882352941176	PXN/PIK3CB/NRAS/KRAS/MAPK13/PPP3CA/PPP3R1/MAPKAPK3/SH2D2A/PIK3R3/PIK3CD/CDC42	1.21247856435531
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/1360	115/9376	1.25892583120205	JUND/RXRA/PDE4A/GNA13/GNAI3/OXSR1/ATF4/ITPR2/ITPR1/HBEGF/BCL2/CDKN1A/ARHGEF1/MAFB/SGK1/BRAF/STK39/PDE4C/PDE4B/PLCB2/ITPR3	1.15072512415499
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	32/1360	184/9376	1.19897698209719	RYK/GNAI3/NCK2/ROCK1/EFNB1/PAK2/PAK1/PIK3CB/LIMK2/SRGAP1/CAMK2G/EFNB2/NRAS/KRAS/PPP3CA/PPP3R1/EPHB3/ENAH/SEMA4A/PAK4/SEMA4C/RASA1/RHOD/NFATC3/NTN4/SEMA4D/PIK3R3/PRKCZ/FES/NTNG2/PIK3CD/CDC42	1.12274978709911
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1360	109/9376	1.26497571505666	PTEN/PPP1CA/OGT/PPP1CB/CRTC2/PIK3CB/RPS6KA3/MLX/PPP1R3B/NFKBIA/IKBKB/CPT1A/PIK3R3/PRKCZ/MAPK8/PRKAG2/PIK3CD/NR1H3/TRIB3/NFKB1	1.1461091464095
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1360	110/9376	1.25347593582888	CREBBP/EP300/TGFB1/ROCK1/LEMD3/ZFYVE16/SMAD3/TFDP1/HDAC1/SIN3A/MYC/BAMBI/LTBP1/SMAD1/SMURF2/TGIF1/CDKN2B/FST/ID2/SKIL	1.10144589302311
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1360	142/9376	1.21375310687655	HSP90AA1/GPC1/HSP90AB1/ARHGEF2/PIK3CB/SUMO1/IL1A/TP53/IKBKB/MAPK13/MAP2K4/PIAS4/SDC4/BCL2/PIK3R3/CYBA/SDC1/ICAM1/VCAM1/PRKCZ/MAPK8/THBD/PIK3CD/SUMO2/NFKB1	1.0571531569977
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1360	38/9376	1.45139318885449	SIRT2/BST1/QPRT/SIRT1/NADSYN1/PNP/SIRT7/NAMPT	1.14840771992321
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/1360	155/9376	1.20091081593928	DYNC1LI1/TCIRG1/SEC22B/HLA-F/TAP2/PIKFYVE/ATP6V0D1/ATP6V1B2/RAB5A/PIK3C3/DYNC1H1/ATP6V0B/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/CYBA/FCGR3B/TUBA1B/HLA-DQB1/ATP6V0A2/TUBB2A/FCGR1A/HLA-DMA/HLA-DQA2/TUBA1C/MARCO	1.03885849057753
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1360	50/9376	1.37882352941176	AOC1/ALDH9A1/SAT1/SMS/CNDP2/ODC1/AMD1/GOT1/L3HYPDH/ALDH2	1.10624286014396
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1360	27/9376	1.53202614379085	ACAA1/TECR/ELOVL5/HACD2/ACOT7/HACD1	1.1402721424845
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/1360	69/9376	1.29889173060529	GRB2/LYN/SOS2/PIK3CB/NRAS/KRAS/MAPK13/MAP2K4/ALOX5/PIK3R3/MAPK8/PIK3CD/SYK	1.02638388856366
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	18/1360	100/9376	1.24094117647059	IL4R/IL1A/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/FLT3LG/MME/CD24/HLA-DQB1/CD7/IL6R/FCGR1A/HLA-DMA/HLA-DQA2/CD1D/IL11RA/CR1	0.997715903137532
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	54/1360	333/9376	1.11796502384738	FN1/PTEN/GRB2/CREBBP/PPP2R2A/PXN/IRF3/TCIRG1/EP300/SOS2/HLA-F/IRF9/PPP2R5C/ATM/HES4/ATP6V0D1/ATP6V1B2/LAMA5/PIK3CB/JAK1/HDAC1/PPP2R2D/ATP6V0B/TSC1/DLG1/TBK1/TP53/MX2/TBPL1/IFNAR2/MDM2/NRAS/KRAS/IKBKB/AXIN1/BAX/NOTCH2/CASP3/MX1/CDKN1A/PPP2R5A/LAMB3/PIK3R3/TBP/AXIN2/PRKCZ/TICAM1/HES1/COL4A2/ATP6V0A2/NOTCH1/PIK3CD/CDC42/NFKB1	0.902807897055146
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1360	22/9376	1.5668449197861	AOC1/ALDH9A1/CNDP2/HNMT/ALDH2	1.09635993001953
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1360	34/9376	1.41937716262976	POLR2A/POLR2F/POLR1D/POLR2G/CRCP/POLR3E/POLR3K	1.00902178358699
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1360	83/9376	1.24592487597449	POLR2F/IRF3/SAMHD1/POLR1D/IRF7/TBK1/NFKBIA/IKBKB/ZCCHC3/POLR3E/CASP3/POLR3K/CGAS/PYCARD/NFKB1	0.926914715058484
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	39/1360	238/9376	1.12970835392981	GRB2/SHOC2/GNG10/SOS2/FLT1/RALA/RRAS2/ARF6/RAB5A/PAK2/PLAAT3/PAK1/PIK3CB/RASA2/RASAL2/TBK1/RALBP1/NRAS/KRAS/IKBKB/PAK4/GNB4/RASA1/GAB1/FLT3LG/PIK3R3/RALGAPA1/ETS1/ELK1/TEK/MAPK8/GNG5/RALGAPA2/STK4/IGF2/PIK3CD/RALGDS/CDC42/NFKB1	0.834847378396058
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1360	109/9376	1.20172692930383	CXCL8/IRF3/IRF9/IRF7/MYD88/PIK3CB/JAK1/TBK1/IFNAR2/NFKBIA/IKBKB/MAPK13/MAP2K4/PIK3R3/CCL3L1/MAPK8/TICAM1/PIK3CD/NFKB1	0.872536861360226
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/1360	193/9376	1.14306613837245	GRB2/CXCL8/LYN/PXN/GNG10/SOS2/GNAI3/ROCK1/PAK1/PIK3CB/FOXO3/NFKBIA/NRAS/KRAS/IKBKB/GNB4/PIK3R3/CCL3L1/JAK2/GRK6/PRKCZ/BRAF/GNG5/XCL1/JAK3/PIK3CD/PREX1/PLCB2/PTK2B/XCL2/CDC42/NFKB1	0.827178914487029
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1360	23/9376	1.49872122762148	FDPS/HMGCR/DHDDS/IDI1/ACAT2	0.986330681774777
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1360	47/9376	1.32015018773467	PIK3CB/SOCS2/IKBKB/SOCS1/PIK3R3/PRKCZ/MAPK8/SOCS4/PIK3CD	0.9062778827402
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1360	12/9376	1.72352941176471	GGCX/COQ6/COQ7	1.0329810362519
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/1360	130/9376	1.16669683257919	GRB2/GNG10/SOS2/TGFB1/GNAI3/ATF4/PIK3CB/NFKBIA/NRAS/KRAS/MAPK13/MAP2K4/GNB4/PIK3R3/PRKCZ/MAPK8/GNG5/COL4A2/ACTA2/PIK3CD/PLCB2/NFKB1	0.788312326634189
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1360	54/9376	1.27668845315904	MAT2A/SMS/ENOPH1/DNMT1/AMD1/GOT1/APIP/GCLM/DNMT3A/MRI1	0.839865234055533
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	24/1360	144/9376	1.14901960784314	GRB2/REST/KAT6A/RIF1/SMAD3/PIK3CB/JAK1/MYC/NRAS/KRAS/ZFHX3/MAPK13/AXIN1/SMAD1/TCF3/LIFR/SETDB1/PIK3R3/JAK2/AXIN2/JAK3/PIK3CD/ID2/SKIL	0.742254778949196
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	26/1360	157/9376	1.14170101161484	RXRA/UQCRFS1/TGFB1/ATP11A/RAB5A/DUSP16/CD47/SIRT1/ODC1/CAMK2G/ATP11B/MAPK13/CASP3/DUSP8/ALOX5/CPT1A/HIF1A/PANX1/NFATC3/DNMT3A/SGK1/CD24/ADAM17/JAK2/DUSP4/NR1H3	0.737491650061121
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	33/1360	203/9376	1.1207186322805	FN1/PTEN/GRB2/PXN/PPP1CA/RAPGEF1/SOS2/CAPN2/FLT1/PPP1R12A/ROCK1/PIP5K1A/ACTN1/LAMA5/BIRC2/PAK2/PPP1CB/PAK1/PIK3CB/ACTN4/FLNB/PAK4/BCL2/LAMB3/PIK3R3/ELK1/MAPK8/BRAF/COL4A2/PIK3CD/PPP1R12B/PIP5K1B/CDC42	0.716214099993096
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	57/1360	362/9376	1.08553786155346	FN1/HSP90AA1/RXRA/PTEN/PKN2/GRB2/PPP2R2A/GNG10/SOS2/EIF4E2/FLT1/PPP2R5C/HSP90AB1/YWHAH/CDC37/LAMA5/ATF4/CRTC2/PIK3CB/JAK1/IL4R/PPP2R2D/TSC1/FOXO3/TP53/MYC/IFNAR2/MDM2/NRAS/DDIT4/KRAS/IKBKB/SGK3/CSH1/BCL2/EIF4E/GNB4/CDKN1A/PPP2R5A/LPAR6/LAMB3/SGK1/FLT3LG/PIK3R3/JAK2/TEK/GNG5/COL4A2/IGF2/IL6R/BCL2L11/JAK3/PIK3CD/AREG/SYK/EREG/NFKB1	0.683644202512462
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1360	55/9376	1.25347593582888	GM2A/NEU1/GLA/CERS5/ASAH1/SMPD2/B4GALT5/UGCG/SGMS2/DEGS2	0.776538627912519
Organismal Systems	Immune system	hsa04611	Platelet activation	21/1360	126/9376	1.14901960784314	APBB1IP/LYN/PPP1CA/GNA13/SNAP23/GNAI3/PPP1R12A/ROCK1/ITPR2/PPP1CB/PIK3CB/FERMT3/ITPR1/MAPK13/ARHGEF1/PIK3R3/PRKCZ/PIK3CD/PLCB2/SYK/ITPR3	0.693639889686474
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1360	37/9376	1.30429252782194	UGP2/PGM1/CMAS/NANS/PMM2/PGM2/UAP1	0.763867795145695
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1360	31/9376	1.33434535104364	PGM1/TALDO1/PGM2/TKT/RPIA/PRPS1	0.768002654377672
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1360	56/9376	1.23109243697479	SPOP/CSNK1G2/CUL3/CSNK1G3/KIF3A/BCL2/SMURF2/HHAT/IQCE/SPOPL	0.714410827264571
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/1360	50/9376	1.24094117647059	TGFB1/HLA-DRB1/TNFSF13/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2	0.703597943346219
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1360	50/9376	1.24094117647059	CXCL8/TGFB1/HBA2/MYD88/HBA1/SDC1/ICAM1/VCAM1/CR1	0.703597943346219
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1360	38/9376	1.26996904024768	ATP1A1/ATP1B3/PIK3CB/KRAS/SGK1/PIK3R3/PIK3CD	0.686839185029517
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	12/1360	70/9376	1.1818487394958	HLA-F/HLA-DRB1/CASP3/CYCS/BID/HLA-DPA1/HLA-DPB1/HLA-DRB5/ICAM1/HLA-DQB1/HLA-DMA/HLA-DQA2	0.629004900616501
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1360	103/9376	1.1378640776699	FN1/CXCL8/TGFB1/ACTN1/LAMA5/RAB5A/PIK3CB/ACTN4/CASP3/LAMB3/GNAL/PIK3R3/COL4A2/PIK3CD/CD1D/PLCB2/NFKB1	0.579476515900303
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1360	39/9376	1.23740573152338	MAT2A/GART/SHMT1/AMT/DHFR/MTHFD2L/MTHFR	0.611921992237832
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1360	65/9376	1.16669683257919	PLPP5/DGKZ/ALDH9A1/LPIN2/GLA/DGKA/DGKD/DGKE/AGPAT4/ALDH2/LPIN3	0.555471909018289
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1360	144/9376	1.10114379084967	ADIPOR2/CXCL8/IRF3/ALDH9A1/MYD88/IL17RA/LPIN2/FOXO3/TBK1/SIRT1/NFKBIA/IKBKB/MAPK13/MAP2K4/CASP3/TRA2B/CPT1A/MAPK8/TICAM1/PRKAG2/ALDH2/LPIN3/NFKB1	0.503789153694684
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	28/1360	178/9376	1.08446794448116	CTBP1/NOTUM/CREBBP/EP300/TBL1XR1/RYK/SMAD3/TLE1/TP53/SIAH1/SIRT1/MYC/CAMK2G/BAMBI/PPP3CA/PPP3R1/AXIN1/NFATC3/TLE4/CELSR1/CTNNBIP1/ANKRD6/AXIN2/FRAT2/MAPK8/PORCN/PLCB2/CACYBP	0.468631484080607
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	16/1360	99/9376	1.11420083184789	KRT18/SELPLG/KRT10/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/FCGR3B/ICAM1/HLA-DQB1/FCGR1A/DEFB1/HLA-DMA/HLA-DQA2/PTAFR/CAMP	0.470499671433394
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1360	73/9376	1.13327961321515	PTEN/PIK3CB/TP53/MDM2/NRAS/KRAS/DDB2/BAX/CDKN1A/PIK3R3/BRAF/PIK3CD	0.470857921752036
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/1360	60/9376	1.14901960784314	LYN/GNA13/GNAI3/ITPR2/ITPR1/NRAS/KRAS/BRAF/PLCB2/ITPR3	0.476958441464823
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1360	93/9376	1.11195445920304	CREBBP/ACP1/PDCD10/EP300/ROCK1/ACTN1/SMAD3/IQGAP1/ACTN4/SMURF2/YES1/SNAI1/LMO7/SSX2IP/CDC42	0.446904711872884
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	21/1360	133/9376	1.08854489164087	PPP2R2A/PPP1CA/GNG10/PPP2R5C/GNAI3/ATF4/ITPR2/PPP1CB/PPP2R2D/CAMK2G/ITPR1/MAPK13/PPP3CA/GNB4/PPP2R5A/GNAL/MAPK8/GNG5/LRTOMT/PLCB2/ITPR3	0.423603064104126
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	9/1360	54/9376	1.14901960784314	HLA-F/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/HLA-DQB1/HLA-DMA/HLA-DQA2/GZMB	0.452336866215736
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1360	28/9376	1.23109243697479	B4GALT4/B4GALT1/B3GNT2/ST3GAL3/ST3GAL4	0.504407614899858
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	24/1360	154/9376	1.07440794499618	RFK/GUSB/MAT2A/UGP2/NME6/PMM2/GGCX/PTS/QPRT/RDH13/GCLM/COQ6/NADSYN1/COQ7/NME7/AFMID/CPOX/SHMT1/DHFR/ALAS1/MTHFD2L/MMAB/ALDH2/CTPS1	0.383480557372268
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	19/1360	122/9376	1.07367405978785	ADIPOR2/PPP2R2A/PPP2R5C/TBC1D1/RAB8A/CRTC2/PIK3CB/PPP2R2D/TSC1/HMGCR/FOXO3/SIRT1/STRADA/CPT1A/PPP2R5A/PIK3R3/RAB2A/PRKAG2/PIK3CD	0.337369648040868
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1360	49/9376	1.12557022809124	GALNT2/C1GALT1C1/OGT/B4GALT1/GALNT7/GALNT4/ST3GAL3/GALNT10	0.362986081756086
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1360	150/9376	1.05709803921569	RXRA/GRB2/SOS2/TGFB1/SMAD3/PIK3CB/TP53/MYC/NRAS/KRAS/AXIN1/DDB2/BAX/BCL2/GAB1/CDKN1A/PIK3R3/CDKN2B/AXIN2/FRAT2/BRAF/PIK3CD/JUP	0.290359698689777
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1360	36/9376	1.14901960784314	GALNT2/C1GALT1C1/B4GALT5/GALNT7/GALNT4/GALNT10	0.368975446172551
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/1360	110/9376	1.06545454545455	HSP90AA1/ANAPC5/HSP90AB1/GNAI3/PIK3CB/ANAPC15/RPS6KA3/CDC26/KRAS/MAPK13/ANAPC1/PIK3R3/CPEB2/MAPK8/BRAF/PIK3CD/STK10	0.284424002755334
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	21/1360	138/9376	1.04910485933504	ANAPC5/PPP1CA/SMC3/SMC1A/PPP2R5C/YWHAH/ITPR2/PPP1CB/ANAPC15/RPS6KA3/CDC26/CAMK2G/ITPR1/MAPK13/PPP3CA/PPP3R1/ANAPC1/PPP2R5A/CPEB2/PTTG1/ITPR3	0.239359833273791
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/1360	37/9376	1.11796502384738	HBA2/MYD88/HBA1/ICAM1/VCAM1/PLCB2	0.296128476488038
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1360	17/9376	1.21660899653979	SEPHS2/PSTK/SCLY	0.368181926333423
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1360	24/9376	1.14901960784314	EXTL3/HS6ST1/GLCE/HS3ST3B1	0.301073843008213
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1360	65/9376	1.0606334841629	ITPR2/PIK3CB/ITPR1/NRAS/KRAS/PIK3R3/KISS1R/PIK3CD/PLCB2/ITPR3	0.202044614029454
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1360	31/9376	1.11195445920304	HYI/AFMID/SHMT1/AMT/ACAT2	0.257163204360288
NA	NA	hsa04981	Folate transport and metabolism	5/1360	31/9376	1.11195445920304	SHMT1/DHFR/MTHFR/ABCG2/SLC19A1	0.257163204360288
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1360	38/9376	1.08854489164087	UGP2/PGM1/PMM2/GNPDA1/PGM2/UAP1	0.225270650135828
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1360	148/9376	1.0248012718601	PTEN/GRB2/SOS2/NFKB2/PIK3CB/NCOA3/TP53/MYC/NRAS/KRAS/AXIN1/DDB2/BAX/NOTCH2/CDKN1A/PIK3R3/AXIN2/FRAT2/BRAF/HES1/NOTCH1/PIK3CD	0.125264282687207
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1360	18/9376	1.14901960784314	ACSL1/ACSL4/ACSL3	0.260653995454457
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1360	18/9376	1.14901960784314	AGA/NEU1/FUCA1	0.260653995454457
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	22/1360	149/9376	1.01792341097513	NDUFA7/NDUFA10/GNG10/NDUFA2/NDUFB5/GNAI3/NDUFA12/ITPR2/NDUFA9/ITPR1/MAPK13/MT-ND6/GNB4/MT-ND3/MT-ND4L/MAPK8/GNG5/MT-ND4/FAAH/MT-ND2/PLCB2/ITPR3	0.0908363709323633
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1360	32/9376	1.07720588235294	UGP2/PGM1/B4GALT1/GLA/PGM2	0.180191874464826
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/1360	115/9376	1.01913043478261	GNG10/GNAI3/ATF4/ITPR2/PIK3CB/CAMK2G/ITPR1/NRAS/KRAS/BCL2/GNB4/PIK3R3/JAK2/GNG5/PIK3CD/PLCB2/ITPR3	0.0850199913935143
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/1360	116/9376	1.01034482758621	PXN/GNAI3/ROCK1/ACTN1/PIK3CB/ACTN4/MAPK13/JAM2/PIK3R3/CYBA/ICAM1/VCAM1/EZR/PIK3CD/PTK2B/CDC42/CLDN7	0.046176710974269
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1360	47/9376	1.02678347934919	ALDH9A1/FH/PDHA1/ME2/ACYP1/ACAT2/ALDH2	0.0758183998852241
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1360	19/9376	1.08854489164087	OGDH/PDHA1/AMT	0.159128597343736
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1360	89/9376	1.00700594844679	GRB2/SOS2/GNAI3/MAP3K2/ITPR2/ITPR1/NRAS/KRAS/TUBA1B/TUBB2A/TUBA1C/PLCB2/ITPR3	0.0273527159773711
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1360	48/9376	1.00539215686275	ATP1A1/ATP1B3/PIK3CB/PIK3R3/PIK3CD/SLC37A4/PLCB2	0.015426418385192
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1360	78/9376	0.972247360482654	CXCL8/IRF3/GNAI3/MYD88/IL1A/MAPK13/CASP3/MAPK8/TICAM1/PYCARD/NFKB1	-0.101375512585452
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1360	28/9376	0.984873949579832	TCIRG1/ATP6V0D1/ATP6V1B2/ATP6V0A2	-0.0330157711570814
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1360	21/9376	0.984873949579832	CSGALNACT2/CHST12/DSEL	-0.0285817971926447
NA	NA	hsa04517	IgSF CAM signaling	42/1360	299/9376	0.968404485540035	GRB2/ARPC4/LYN/DYNLL2/PXN/PVR/NCK2/ACTN1/ARF6/CD2AP/PAK2/EPB41L3/IQGAP1/PAK1/PIK3CB/GIT1/ACTR3/ARPC5L/ACTN4/SRGAP1/ARPC5/ARPC1B/MAPK13/PAK4/MYH10/RASA1/CD84/JAM2/RAPGEF6/PIK3R3/TUBA1B/ICAM1/MAPK8/EZR/LMO7/TUBB2A/CD226/RAPGEF2/SSX2IP/PIK3CD/TUBA1C/CDC42	-0.228699963767799
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1360	51/9376	0.946251441753172	TCIRG1/ATP6V0D1/ATP6V1B2/ATP6V0B/KDELR3/ATP6V0A2/SLC12A2	-0.158527176717801
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1360	44/9376	0.940106951871658	DYNC1LI1/DYNLL2/STX4/RAB5A/DYNC1H1/ARHGDIB	-0.164018043635371
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1360	30/9376	0.91921568627451	FH/OGDH/PDHA1/IDH2	-0.182537045587255
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1360	45/9376	0.91921568627451	TAP2/ABCA7/ABCG1/ABCB9/DEFB1/ABCG2	-0.223740930668746
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/1360	140/9376	0.93563025210084	GNA13/GNG10/GNAI3/RRAS2/HDAC5/ITPR2/SMAD3/PIK3C3/ITPR1/NRAS/KRAS/GNB4/MAP1LC3B2/AGTR1/GNG5/ACTA2/PRKAG2/PLCB2/ITPR3	-0.316067689780133
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/1360	155/9376	0.93404174573055	CYP11A1/USP8/GNAI3/FH/ATF4/ITPR2/RBBP5/CDKN2C/CAMK2G/ITPR1/KMT2D/POMC/AXIN1/CDKN1A/CDKN2B/AXIN2/AGTR1/BRAF/MEN1/PLCB2/ITPR3	-0.34105327854623
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1360	23/9376	0.89923273657289	PRCP/MME/AGTR1	-0.199289378779109
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1360	23/9376	0.89923273657289	ATP1A1/ATP1B3/GLS	-0.199289378779109
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1360	31/9376	0.889563567362429	ALDH9A1/CNDP2/CSAD/ALDH2	-0.253676245657097
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1360	98/9376	0.91452581032413	CYP11A1/ATP1A1/PRKD3/ATF4/ITPR2/ATP1B3/CAMK2G/ITPR1/POMC/PRKD2/AGTR1/PLCB2/ITPR3	-0.350345936040001
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/1360	69/9376	0.89923273657289	PPP1CA/ATF4/PPP1CB/HDAC1/SIRT1/CAMK2G/PPP3CA/PPP3R1/ARC	-0.346031305271605
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1360	128/9376	0.915625	PDE4A/GMPS/ADA2/PGM1/ENTPD4/DGUOK/NME6/ADK/GART/PGM2/PNP/NME7/DCK/ENTPD5/PDE4C/PDE4B/PRPS1	-0.395886870077982
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1360	99/9376	0.905288175876411	PPP1CA/ITPR2/PPP1CB/PIK3CB/CAMK2G/ITPR1/MAPK13/PIK3R3/MAPK8/TRPV2/PIK3CD/PLCB2/ITPR3	-0.39020628317629
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	21/1360	160/9376	0.904852941176471	PVR/VSIR/HLA-F/SELPLG/HLA-DRB1/ALCAM/CD58/SDC4/JAM2/HLA-DPA1/HLA-DPB1/HLA-DRB5/SDC1/ICAM1/VCAM1/HLA-DQB1/NTNG2/CD226/HLA-DMA/HLA-DQA2/CLDN7	-0.499988901707052
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1360	33/9376	0.835650623885918	OGDH/PDHA1/GOT1/IDH2	-0.389545411791781
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	24/1360	183/9376	0.904146576663452	GNL3/EIF6/NOP58/XRN2/TCOF1/GTPBP4/NXF1/UTP6/RPP30/GNL3L/DKC1/NOP10/WDR43/NOB1/UTP18/POP5/GAR1/RPP25L/RIOK1/NXT1/UTP14A/RCL1/RPP40/NVL	-0.539362540682975
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/1360	154/9376	0.895339954163483	PPP1CA/GNAI3/PPP1R12A/ROCK1/ITPR2/PPP1CB/CAMK2G/ITPR1/NRAS/KRAS/PPP3CA/PPP3R1/CDKN1A/NFATC3/ELK1/PRKAG2/TRPM2/PPP1R12B/PLCB2/ITPR3	-0.53939257043122
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1360	65/9376	0.848506787330317	CYP11A1/ATF4/ITPR2/ITPR1/POMC/AGTR1/PLCB2/ITPR3	-0.504809975948217
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1360	34/9376	0.811072664359862	NFIL3/PER1/NR1D2/PRKAG2	-0.454559318348595
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1360	42/9376	0.820728291316527	AOC1/ALDH9A1/AFMID/ACAT2/ALDH2	-0.47959952347814
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1360	26/9376	0.795475113122172	ACAA1/PLAAT3/PLB1	-0.430133499859953
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1360	26/9376	0.795475113122172	SLC5A6/PLB1/SLC19A1	-0.430133499859953
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	43/1360	323/9376	0.917792751775633	PTEN/GRB2/CREBBP/UBE2I/EP300/SOS2/ATM/ROCK1/CCNG1/HDAC5/PIK3CB/HDAC1/TP53/PDCD4/SIRT1/DNMT1/MYC/MDM2/NRAS/DDIT4/KRAS/IKBKB/PIM1/MDM4/PAK4/GLS/NOTCH2/BCL2/CASP3/CDKN1A/FOXP1/DNMT3A/SOCS1/PIK3R3/HNRNPK/SLC7A1/EZR/NOTCH1/BCL2L11/PIK3CD/STMN1/TPM1/NFKB1	-0.619286125443887
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1360	18/9376	0.766013071895425	ZNF143/MMAB	-0.40927250163463
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1360	35/9376	0.787899159663866	ENOSF1/PMM2/TIGAR/SORD	-0.51779274782502
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1360	75/9376	0.827294117647059	ATP1A1/TTF1/ATF4/ITPR2/ATP1B3/ITPR1/TTF2/PLCB2/ITPR3	-0.618513491867783
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1360	44/9376	0.783422459893048	ALG3/DDOST/B4GALT1/ALG13/ST3GAL3	-0.593100961360048
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/1360	52/9376	0.795475113122172	MYLIP/VDAC2/VAPA/SORT1/APOC1/TSPO	-0.609148162707125
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1360	36/9376	0.766013071895425	UGP2/PGM1/AGL/PGM2	-0.579356183025322
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1360	76/9376	0.81640866873065	RXRA/ACAA1/ACSL1/DBI/ACSL4/ACSL3/CPT1A/UBC/NR1H3	-0.661902057408682
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1360	76/9376	0.81640866873065	GNAI3/ATP1A1/ITPR2/ATP1B3/CAMK2G/ITPR1/EZR/PLCB2/ITPR3	-0.661902057408682
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1360	28/9376	0.738655462184874	QDPR/PTS/DHFR	-0.570439157214021
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1360	69/9376	0.799317988064791	GNAI3/ITPR2/ITPR1/PPP3CA/PPP3R1/AGTR1/PLCB2/ITPR3	-0.689135103730421
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	14/1360	116/9376	0.832048681541582	ADPGK/FH/OGDH/PDHA1/TALDO1/ME2/GOT1/TKT/SHMT1/AMT/RPIA/ACAT2/IDH2/PRPS1	-0.749692484052831
NA	NA	hsa04518	Integrin signaling	19/1360	154/9376	0.85057295645531	FN1/PXN/TGFB1/FLT1/NCK2/ACTN1/LAMA5/PIK3CB/FERMT3/ACTN4/FLNB/LAMB3/PIK3R3/ICAM1/VCAM1/COL4A2/PIK3CD/ICAM4/CDC42	-0.770110852382092
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1360	46/9376	0.749360613810742	FTL/GUSB/CPOX/ALAS1/MMAB	-0.701881265399742
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1360	87/9376	0.792427315753888	ASPH/UQCRFS1/ATP1A1/COX5A/ATP1B3/COX7A2/UQCRH/TPM3/TPM1/UQCRB	-0.801164291970679
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1360	21/9376	0.656582633053221	CSAD/ALDH2	-0.648912654781154
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/1360	134/9376	0.823178226514486	PPP1CA/GNA13/PPP1R12A/ROCK1/ITPR2/PPP1CB/ITPR1/CALCRL/MYH10/ARHGEF1/AGTR1/BRAF/ACTA2/PPP1R12B/PLCB2/ITPR3	-0.849144101867907
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/1360	48/9376	0.718137254901961	ACAA1/ACAA2/ALDH9A1/ACAT2/ALDH2	-0.806380961044117
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/1360	166/9376	0.830616583982991	PPP1CA/GNA13/GNAI3/ATP1A1/PPP1R12A/ROCK1/ATF4/ITPR2/PPP1CB/ATP1B3/VDAC2/ITPR1/PPP3CA/PPP3R1/NFATC3/SLC25A5/AGTR1/PPIF/PLCB2/ITPR3	-0.906924959394953
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1360	31/9376	0.667172675521822	GUSB/ALDH9A1/ALDH2	-0.764515695674482
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/1360	82/9376	0.756671449067432	GUSB/GMPS/CDA/NME6/TYMP/UCK2/CDADC1/NME7/UPP1	-0.911538255903951
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1360	41/9376	0.672596843615495	BPGM/SHMT1/AMT/ALAS1	-0.86535412319909
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1360	23/9376	0.599488491048593	GOT1/GLS	-0.792099409056052
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1360	23/9376	0.599488491048593	B4GALT1/ST3GAL3	-0.792099409056052
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1360	115/9376	0.779335038363171	GNG10/GNAI3/ITPR2/ITPR1/NRAS/KRAS/GNB4/CASP3/ALOX5/BRAF/GNG5/PLCB2/ITPR3	-0.980685141367964
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/1360	75/9376	0.735372549019608	MAT2A/TALDO1/GOT1/TKT/SHMT1/RPIA/IDH2/PRPS1	-0.947713225050818
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/1360	67/9376	0.720280948200176	ADPGK/ALDH9A1/PGM1/PDHA1/BPGM/PGM2/ALDH2	-0.946420571747493
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1360	59/9376	0.701096709870389	GSTK1/SMS/ODC1/GGCT/GCLM/IDH2	-0.94862571176717
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1360	59/9376	0.701096709870389	GNAI3/PLAAT3/PIK3CB/ABHD5/PIK3R3/PIK3CD	-0.94862571176717
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/1360	194/9376	0.817343844754396	DYNC1LI1/DYNLL2/CAPZA2/MYO9B/MYO1E/DYNC1H1/DYNLT1/MYO6/KIF3A/MYH10/KIF2A/KIF13B/TUBA1B/TPM3/DNALI1/ACTA2/TUBB2A/TUBA1C/TPM1/KIF9/MYO19/KIF27/TUBD1	-1.05887030903073
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1360	93/9376	0.741302972802024	LYZ/ATP1A1/ITPR2/ATP1B3/BST1/ITPR1/SLC12A2/CAMP/PLCB2/ITPR3	-1.03267811952548
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1360	61/9376	0.678109932497589	FTL/ATP1A1/SLC31A1/ATP1B3/TRPM7/SLC39A4	-1.03886066341407
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1360	15/9376	0.459607843137255	ACP1	-0.862719833103986
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1360	63/9376	0.656582633053221	TP53/AXIN1/DDB2/BAX/CDKN1A/AXIN2	-1.1264812449329
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1360	36/9376	0.574509803921569	GUSB/UGP2/SORD	-1.05352199762426
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/1360	154/9376	0.761038961038961	PPP2R2A/PPP1CA/PPP2R5C/GNAI3/ATP1A1/ATF4/PPP1CB/ATP1B3/PPP2R2D/CAMK2G/MAPK13/BCL2/PPP2R5A/TPM3/AGTR1/TPM1/PLCB2	-1.23154741628384
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1360	16/9376	0.430882352941176	GOT1	-0.93842670349841
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1360	16/9376	0.430882352941176	GLA	-0.93842670349841
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1360	27/9376	0.510675381263617	ACAT2/L2HGDH	-1.04875152826379
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1360	37/9376	0.558982511923688	GOT1/GLS/RIMKLB	-1.10708947948493
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1360	56/9376	0.615546218487395	ALG3/MGAT5/DDOST/B4GALT1/ALG13	-1.18851983081288
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1360	116/9376	0.713184584178499	GNG10/GNAI3/ITPR2/ITPR1/PPP3CA/PPP3R1/GLS/GNB4/GNG5/SHANK3/PLCB2/ITPR3	-1.28027194740423
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1360	38/9376	0.544272445820433	TAP2/DCLRE1C/JAK3	-1.15943495454524
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/1360	157/9376	0.746496815286624	PPP2R2A/PPP1CA/TGFB1/YWHAH/BIRC2/SMAD3/PPP1CB/PPP2R2D/DLG1/TP53BP2/MYC/AXIN1/SMAD1/AXIN2/PRKCZ/AREG/ID2	-1.31937295196022
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1360	17/9376	0.405536332179931	CSAD	-1.01044177226968
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1360	17/9376	0.405536332179931	MYH10	-1.01044177226968
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1360	29/9376	0.475456389452333	PAK1/RASSF2	-1.1652543074109
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/1360	102/9376	0.675893886966551	ATP1A1/ITPR2/RAB8A/ATP1B3/BST1/ITPR1/RAB27B/SLC12A2/PLCB2/ITPR3	-1.35559513217238
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1360	30/9376	0.459607843137255	PLAAT3/PLB1	-1.22104878067591
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1360	19/9376	0.362848297213622	GUSB	-1.14505822843849
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	21/1360	195/9376	0.742443438914027	HDAC5/VDAC2/PIK3CB/HDAC1/SELPLG/CASP4/MAPK13/HAT1/SLC25A5/PIK3R3/CYBA/HDAC8/FCGR3B/PPIF/FCGR1A/PIK3CD/CAMP/PLCB2/SYK/NFKB1/CR1	-1.49699781976849
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1360	51/9376	0.540715109573241	LPCAT1/PLAAT3/PLA2G7/PLB1	-1.35462493066585
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1360	31/9376	0.444781783681214	SEC11A/SRP54	-1.27535514569187
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1360	97/9376	0.639660400242571	GNG10/GNAI3/PER1/CAMK2G/ITPR1/GNB4/GNG5/PLCB2/ITPR3	-1.46934408739917
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/1360	53/9376	0.52031076581576	DNM2/ATP1A1/ATP1B3/PLCB2	-1.44243516802626
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1360	63/9376	0.547152194211018	PLAAT3/ALOX5/PLB1/PTGES/HPGD	-1.48543611689086
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/1360	91/9376	0.606076276664512	PDE4A/GNG10/GNAI3/GNB4/GRK6/GNG5/PDE4C/PDE4B	-1.55531412591654
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/1360	100/9376	0.620470588235294	CXCL8/TNFRSF14/IL18R1/TNFSF10/CCL3L1/TNFRSF10B/XCL1/IL6R/XCL2	-1.57159741382894
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/1360	212/9376	0.71542730299667	APBB1IP/RAPGEF1/FLT1/GNAI3/PRKD3/RALA/PIK3CB/NRAS/KRAS/MAPK13/ENAH/PRKD2/RAPGEF6/PIK3R3/TEK/PRKCZ/BRAF/RAPGEF2/PIK3CD/RALGDS/PLCB2/CDC42	-1.7262148890676
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1360	66/9376	0.522281639928699	CYP11A1/HSD17B11/HSD17B7/SULT2B1/LRTOMT	-1.60415119141294
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1360	103/9376	0.602398629354654	ATP1A1/PRCP/COL27A1/ATP1B3/SLC1A5/SLC3A2/KCNE3/MME/COL4A2	-1.67121603301488
NA	NA	hsa03272	Virion - Hepatitis viruses	3/1360	48/9376	0.430882352941176	IST1/CHMP1B/CLDN7	-1.62818834047343
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1360	37/9376	0.372655007949126	GOT1/LRTOMT	-1.57482879814259
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1360	217/9376	0.698942802927623	HSP90AA1/RXRA/GRB2/SOS2/KPNA4/HSP90AB1/GNAI3/ATF4/PIK3CB/RPS6KA3/MYC/NRAS/KRAS/NOTCH2/BCL2/KPNA2/BCL6/PIK3R3/STAT5A/JAK2/PIK3CD/NFKB1	-1.84812392582754
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/1360	226/9376	0.70161374284227	CREBBP/PDE4A/PPP1CA/EP300/GNAI3/ATP1A1/PPP1R12A/ROCK1/RRAS2/PPP1CB/PAK1/ATP1B3/PIK3CB/CAMK2G/NFKBIA/POMC/PIK3R3/MAPK8/BRAF/PDE4C/PDE4B/PIK3CD/NFKB1	-1.87024596968755
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/1360	79/9376	0.523603871928518	DNM2/TCIRG1/ATP6V0D1/ATP6V1B2/ATP6V0B/ATP6V0A2	-1.75140502479799
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1360	49/9376	0.422088835534214	GNAI3/ATF4/NFKB1	-1.6705688313325
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/1360	89/9376	0.542233972240582	FN1/LAMA5/CD47/SDC4/LAMB3/SDC1/COL4A2	-1.78721614018183
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/1360	143/9376	0.626737967914438	SNRPB/SNRPD1/ACTN1/ACTN4/HLA-DRB1/HLA-DPA1/HLA-DPB1/HLA-DRB5/FCGR3B/HLA-DQB1/FCGR1A/HLA-DMA/HLA-DQA2	-1.8526213095459
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1360	26/9376	0.265158371040724	HES1	-1.54543540657647
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/1360	101/9376	0.546068724519511	CREBBP/EP300/GNAI3/CAMK2G/NRAS/KRAS/POMC/PLCB2	-1.88916578835652
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/1360	52/9376	0.397737556561086	CYP11A1/ALOX5/HSD17B7	-1.79375266496279
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/1360	86/9376	0.480984952120383	ATP1A1/ATF4/ATP1B3/CAMK2G/PLCB2/ITPR3	-1.99157908295261
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1360	30/9376	0.229803921568627	PIGA	-1.74030464822024
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/1360	233/9376	0.65094673062358	FN1/CAPZA2/EMD/ATP1A1/COL27A1/FHL2/ATP1B3/CSRP1/PDLIM5/SYNE1/SDC4/MYH10/PDLIM7/SDC1/FMNL1/TPM3/COL4A2/LMNB2/FHL3/JUP/LBR/TPM1	-2.22229418004089
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/1360	89/9376	0.464771976206213	GNG10/GNAI3/GABARAPL1/GLS/GNB4/GNG5	-2.08964428287503
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1360	191/9376	0.613612565445026	GRB2/PPP1CA/GNG10/SOS2/GNAI3/HDAC5/ATF4/PPP1CB/HDAC1/NRAS/KRAS/GNB4/HAT1/HDAC8/BRAF/GNG5/SLC29A3	-2.22216516887187
NA	NA	hsa04382	Cornified envelope formation	20/1360	217/9376	0.635402548116021	S100A8/S100A9/PPP2R2A/FURIN/PPP2R5C/S100A11/KRT18/LAMA5/PPP2R2D/KRT10/KRT8/BLMH/PPP2R5A/ABHD5/LAMB3/UGCG/S100A12/COL4A2/JUP/CLDN7	-2.23818357665951
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1360	254/9376	0.624270495599815	ASPH/FLT1/ITPR2/VDAC2/CAMK2G/ITPR1/PHKG2/ORAI2/PPP3CA/PPP3R1/TFEB/P2RX4/NFATC3/SLC25A5/GNAL/MST1/AGTR1/STIM2/PPIF/PTAFR/PLCB2/PTK2B/ITPR3	-2.50047986715719
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1360	88/9376	0.391711229946524	SERPINE2/PROCR/THBD/PLAUR/CR1	-2.36138211519693
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1360	90/9376	0.383006535947712	RXRA/ATP1A1/ATP1B3/HMGCR/ABCG2	-2.42249961475825
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1360	43/9376	0.160328317373461	ACAT2	-2.27305183806401
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/1360	298/9376	0.601500197394394	CXCL8/IFNGR1/TNFRSF14/TGFB1/TNFSF12/TNFRSF12A/IL17RA/IFNGR2/IL4R/IL1A/IFNAR2/TNFSF13/RELT/IL32/CSH1/LIFR/IL18R1/TNFSF10/CCL3L1/TNFRSF10B/EBI3/XCL1/IL6R/IL17RE/IL11RA/XCL2	-2.87950204676783
NA	NA	hsa04081	Hormone signaling	17/1360	219/9376	0.535159817351598	ADIPOR2/GNA13/GNG10/GNAI3/PIK3CB/POMC/SMAD1/CSH1/GNB4/PIK3R3/STAT5A/JAK2/AGTR1/GNG5/IGF2/PIK3CD/PLCB2	-2.86698454368659
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/1360	99/9376	0.348187759952466	EMD/TGFB1/TPM3/PRKAG2/TPM1	-2.68542216213545
NA	NA	hsa04519	Cadherin signaling	38/1360	404/9376	0.648456610366919	ARPC4/CREBBP/PPP1CA/SHOC2/EP300/RYK/MYO1E/KRT18/ROCK1/YWHAH/ACTN1/RRAS2/PPP1CB/TAOK3/ACTR3/ARPC5L/KRT10/ACTN4/ARPC5/NFKBIA/NRAS/ARPC1B/KRT8/KRAS/IKBKB/MAPK13/ENAH/AXIN1/CIB2/CELSR1/ANKRD6/AXIN2/MAPK8/JUP/FMN1/PTK2B/CDC42/NFKB1	-2.97509764491392
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1360	68/9376	0.202768166089965	RDH13/DHRS4L2	-2.71761004520318
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1360	70/9376	0.196974789915966	GSTK1/SULT1A1	-2.77762053155789
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/1360	105/9376	0.262633053221289	EMD/TGFB1/TPM3/TPM1	-3.12961751124765
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1360	86/9376	0.160328317373461	PLCB2/ITPR3	-3.22201170563077
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/1360	86/9376	0.160328317373461	EMD/JUP	-3.22201170563077
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1360	73/9376	0.0944399677679291	GSTK1	-3.19921482747847
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/1360	79/9376	0.0872673119880864	GSTK1	-3.35553654172769
NA	NA	hsa04082	Neuroactive ligand signaling	9/1360	199/9376	0.311794265444871	TAC3/GNG10/GNAI3/POMC/GNB4/P2RX4/GNAL/GNG5/PLCB2	-4.04176163867492
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1360	370/9376	0.260858505564388	TAC3/PGRMC1/NR3C1/POMC/CALCRL/CSH1/P2RX4/LPAR6/CHRNB1/AGTR1/KISS1R/PTAFR/NMB/TSPO	-5.97501104639842
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1360	449/9376	0.0307087645748723	CAMK2G/GNAL	-8.66963726273958