category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/910	122/9376	3.80039632498649	FYN/CBLB/PPP2R5C/NFATC2/CD3G/CD247/PRKCQ/PPP2R2B/CARD11/PPP3CC/SOS1/CD8A/MAPK8/PPP3CA/ITK/VAV3/RASGRP1/MAP3K8/GRAP2/PIK3R1/DLG1/PPP2R2D/MAPK1/CD3D/GSK3B/NFKB1/MALT1/PPP2R5A/PPP2R3A/NFATC3/SOS2/CD8B/CD3E/PPP2R5E/PPP3CB/RAF1/MAP2K1/PIK3CD/NCK1/VAV1/PAK2/GRB2/ICOS/PPP2R2A/PPP2R3C	10.2070882363118
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	59/910	253/9376	2.40274508100595	H3-3A/H3-3B/U2AF1/FNBP1/SEPTIN7/ELMO1/CYTH1/PRKCQ/MYL12A/ARPC2/MAPK8/RPS6KA5/FOXO1/SEPTIN6/PIK3R1/RPTOR/PFN1/BCL2/FBXW11/DIAPH1/MAPK1/CAST/GSK3B/PRKCE/NFKB1/ITGB1/PXN/MALT1/ACTR3/ARPC3/CD44/MYL12B/PLCB1/ARPC5/ATG5/BTRC/UBA52/ITPR1/CUL1/RPS27A/GLMN/ACTR2/PIK3CD/SEPTIN11/ATM/ACTG1/H3C4/TAB2/TLN1/RPS6KB1/RBX1/ARPC5L/ITPR2/CYTH3/ARPC4/ACTB/RAC1/ELMO2/UBE2D2	7.4154477623557
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	55/910	250/9376	2.26672527472527	RAB11A/CBLB/CYTH1/SH3KBP1/ARAP2/EPS15/GRK5/ARPC2/CAPZB/CAPZA1/ARFGEF1/VPS37B/ACAP2/GBF1/ASAP1/WIPF1/RABEP1/TGFBR2/RAB7A/SMURF2/ARF5/ACTR3/ARPC3/RAB22A/AP2B1/ARPC5/RAB10/SMAP1/VPS4B/SH3GLB1/DNM2/MVB12B/IQSEC1/AGAP1/IGF2R/VPS36/IL2RB/ACTR2/ARFGAP3/EPS15L1/PDCD6IP/SNX1/VPS26A/RBSN/BIN1/ARFGEF2/CBL/CAPZA2/ARPC5L/SMAP2/PRKCI/CYTH3/SMAD3/ARPC4/SNX4	6.65548042507594
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	38/910	142/9376	2.75722024454419	CBLB/BIRC6/HERC1/COP1/FBXW7/PIAS1/CUL3/UBE2Q1/UBE2K/UBE2H/UBR5/FBXW11/SMURF2/HUWE1/UBE2G1/UBE2O/WWP2/CDC27/BTRC/UBA52/UBE4A/UBE3A/CUL4A/ELOB/CUL1/RPS27A/UBE2R2/UBE3C/UBE2B/UBA6/CUL2/UBE2L3/CUL5/TRIP12/RBX1/CBL/UBE2E3/UBE2D2	6.91739598362332
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	36/910	138/9376	2.68781653129479	NFATC2/ELMO1/ITGA4/MAP2K4/RPS6KA3/CD8A/GNAQ/ARPC2/MAPK8/ARHGEF7/VAV3/PIK3R1/MAPK1/WIPF1/GSK3B/NFKB1/ITGB1/FYB1/PXN/ACTR3/ARPC3/NFATC3/CD8B/ARPC5/PKN2/ACTR2/MAP2K1/PIK3CD/VAV1/ACTG1/TAB2/ARPC5L/ARPC4/ACTB/RAC1/ELMO2	6.54851765612663
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	50/910	232/9376	2.22053808260705	CYRIB/BRAF/SSH2/TMSB4X/MSN/ITGA4/IQGAP2/PIP4K2A/SOS1/MYL12A/ARPC2/ARHGEF7/VAV3/PIK3R1/PFN1/ITGAL/CYFIP2/DIAPH1/MAPK1/PPP1CA/GNA13/ITGB1/PXN/MYH9/ACTR3/ARPC3/IQGAP1/PDGFD/MYL12B/RRAS2/SOS2/ARPC5/DIAPH2/PPP1R12A/PPP1R12B/CYRIA/ACTR2/CFL1/RAF1/MAP2K1/PIK3CD/VAV1/PAK2/ACTG1/ARPC5L/FGD3/ARPC4/ARHGAP35/ACTB/RAC1	6.1715523984556
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/910	67/9376	3.22939150401837	RAP1B/BRAF/PRKCB/PPP3CC/CAMK4/RPS6KA3/GNAQ/PPP3CA/PRKACB/RAP1A/CAMK2D/MAPK1/PPP1CA/CREBBP/PLCB1/ITPR1/CALM1/PPP3CB/RAF1/MAP2K1/ITPR2	6.00398267298464
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	44/910	214/9376	2.11843483619185	GNG2/NFATC2/CD3G/CD247/PRKCB/PPP3CC/GNAQ/MAPK8/PPP3CA/GNB1/PIK3R1/BCL2/FBXW11/MAPK1/PDIA3/CD3D/NFKB1/PXN/NFATC3/BTRC/CASP8/CD3E/ITPR1/CUL4A/ELOB/CALM1/CUL1/PPP3CB/CFL1/RAF1/MAP2K1/PIK3CD/TNFRSF1B/ATM/PAK2/AP1G1/SAMHD1/TAB2/CUL5/RPS6KB1/RBX1/ITPR2/APOBEC3C/RAC1	5.42612295964103
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/910	125/9376	2.47279120879121	FYN/PPP2R5C/PRKCB/PPP2R2B/GNAQ/MAPK8/PIK3R1/MAP3K5/BCL2/PPP2R2D/MAPK1/SGMS1/PRKCE/NFKB1/GNA13/PPP2R5A/PLCB1/PPP2R3A/PPP2R5E/GAB2/RAF1/CERS5/MAP2K1/S1PR5/PIK3CD/NSMAF/PPP2R2A/SPTLC2/PPP2R3C/RAC1	5.43461835792249
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	24/910	90/9376	2.74754578754579	EML4/NFATC2/CD3G/CD247/PRKCQ/PPP3CC/STAT1/PPP3CA/JAK1/RASGRP1/PIK3R1/MAPK1/CD3D/NFKB1/NFATC3/CD3E/PPP3CB/RAF1/MAP2K1/PIK3CD/IFNGR1/CSNK2A1/RPS6KB1/JAK2	5.46138358791305
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	20/910	70/9376	2.94379905808477	RAP1B/BRAF/TGFB1/ETS1/SOS1/RAPGEF1/RAP1A/PIK3R1/MAPK1/CREBBP/SOS2/ELOB/RAF1/MAP2K1/PIK3CD/CUL2/PAK2/GRB2/RBX1/RAC1	5.35162982643552
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	28/910	120/9376	2.40410256410256	RAP1B/BRAF/CAMK4/ARHGDIB/SOS1/RPS6KA3/RAPGEF1/MAPK8/RPS6KA5/RAP1A/PIK3R1/MAP3K5/CAMK2D/BCL2/MAPK1/GSK3B/NFKB1/SOS2/MATK/PSEN1/CALM1/RAF1/MAP2K1/PIK3CD/ABL1/FRS2/GRB2/RAC1	5.07510444940286
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/910	77/9376	2.80999000999001	RUNX1/BRAF/TGFB1/STAT5B/SOS1/CDK6/RB1/PIK3R1/MAPK1/TGFBR2/NFKB1/SOS2/BCR/GAB2/RAF1/MAP2K1/PIK3CD/ABL1/GRB2/CBL/SMAD3	5.22842182502244
NA	NA	hsa04517	IgSF CAM signaling	53/910	299/9376	1.82633687382851	FYN/RAP1B/PRKCB/PRKCQ/MBP/MSN/ITGA4/CD96/MYL12A/ARPC2/MAPK8/FOXO1/VAV3/RAP1A/CASK/PIK3R1/RASA1/ITGAL/RAPGEF2/MAPK1/GSK3B/SH2D1A/ITGB1/PXN/MYH9/ACTR3/ARPC3/IQGAP1/SLAMF7/MYL12B/ARPC5/ERC1/NCAM1/CD226/ACTR2/MAP2K1/GRIP1/PIK3CD/NCK1/VAV1/SH2D1B/ABL1/PAK2/ACTG1/ANK3/GRB2/MYL6/ARPC5L/PRKCI/CD244/ARPC4/ACTB/RAC1	4.76089673414657
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/910	78/9376	2.77396449704142	ELMO1/ARPC2/SEPTIN6/PIK3R1/ITGB1/PXN/ACTR3/ARPC3/ARPC5/DNM2/ACTR2/PIK3CD/SEPTIN11/ARHGAP10/ACTG1/CBL/ARPC5L/ARPC4/ACTB/RAC1/ELMO2	5.15780188574754
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	23/910	91/9376	2.60412993599807	IFITM1/NFATC2/PRKCB/CARD11/PPP3CC/SOS1/PPP3CA/VAV3/PIK3R1/MAPK1/GSK3B/NFKB1/MALT1/PIK3AP1/NFATC3/SOS2/PPP3CB/RAF1/MAP2K1/PIK3CD/VAV1/GRB2/RAC1	5.04122972129701
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/910	98/9376	2.52325633550123	PRKCB/ARPC2/VAV3/PIK3R1/ASAP1/MAPK1/PRKCE/ACTR3/ARPC3/ARPC5/DNM2/GAB2/ACTR2/CFL1/RAF1/MAP2K1/PIK3CD/VAV1/PLPP1/BIN1/RPS6KB1/ARPC5L/ARPC4/RAC1	4.96965281062574
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/910	93/9376	2.54812714167553	STAT4/NFATC2/CD3G/CD247/PRKCQ/RUNX3/PPP3CC/STAT5B/MAML2/STAT1/MAPK8/PPP3CA/JAK1/IL12RB2/MAPK1/CD3D/NFKB1/NFATC3/CD3E/PPP3CB/IL2RB/IFNGR1/JAK2	4.91893547966077
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	29/910	133/9376	2.24658349169627	FYN/GZMB/NFATC2/BRAF/CD247/PRKCB/PRF1/PPP3CC/HCST/SOS1/KLRD1/PPP3CA/VAV3/PIK3R1/ITGAL/MAPK1/KLRC4-KLRK1/SH2D1A/SOS2/PPP3CB/RAF1/MAP2K1/PIK3CD/VAV1/SH2D1B/IFNGR1/GRB2/CD244/RAC1	4.74687633364758
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	25/910	109/9376	2.36314144571025	NFATC2/RUNX1/CD3G/CD247/PRKCQ/TGFB1/PPP3CC/STAT5B/STAT1/MAPK8/PPP3CA/IL21R/JAK1/MAPK1/TGFBR2/CD3D/NFKB1/NFATC3/RORA/CD3E/PPP3CB/IL2RB/IFNGR1/SMAD3/JAK2	4.69301337861711
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	32/910	157/9376	2.10003499685028	NFATC2/TGFB1/PPP3CC/ETS1/CDK6/PPP3CA/FOXO1/RB1/PIK3R1/FBXW11/MAPK1/PPP1CA/TGFBR2/NFKB1/CCND3/RRAS2/NFATC3/BTRC/ITPR1/CALM1/PPP3CB/HIPK3/RAF1/HIPK1/MAP2K1/PIK3CD/MCU/ATM/HIPK2/LIN52/ITPR2/SMAD3	4.55702722471168
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	21/910	86/9376	2.51592128801431	CBLB/BRAF/PRKCB/MAP2K4/STAT5B/SOS1/MAPK8/PIK3R1/CAMK2D/MAPK1/GSK3B/SOS2/RAF1/MAP2K1/PIK3CD/NCK1/ABL1/PAK2/GRB2/RPS6KB1/CBL	4.63004511399688
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	44/910	248/9376	1.82800425381071	ELMO1/CYTH1/EXOC4/MAP2K4/RHOH/MYL12A/ARPC2/MAPK8/DYNLT1/PFN1/BCL2/CYFIP2/MAPK1/RAB7A/SNX9/NFKB1/EXOC2/ARL8B/DCTN4/ACTR3/ARPC3/MYL12B/FLNA/KPNA1/ABI1/ARPC5/CASP8/DNM2/ACTR2/RAF1/MAP2K1/PIK3CD/KPNA3/ACTG1/TAB2/ACTR10/ARPC5L/PIK3C2A/DCTN5/CYTH3/ARPC4/ACTB/RAC1/ELMO2	4.3324922542798
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/910	93/9376	2.43733900508094	FYN/RAP1B/PTPRJ/YES1/MYL12A/RAP1A/MAPK1/TGFBR2/CREBBP/SMURF2/IQGAP1/MYL12B/FER/NLK/ACTG1/PDCD10/CSNK2A1/PTPN1/CCM2/SMAD3/ACTB/RAC1	4.56692324426335
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	33/910	169/9376	2.01188633851356	BIRC6/PRKCQ/MAPK8/RAB1A/AMBRA1/PRKACB/PIK3R1/RPTOR/TAX1BP1/BCL2/UVRAG/MAPK1/ATG7/RAB7A/RB1CC1/RRAS2/EIF2AK3/MTMR3/ATG5/UBA52/ITPR1/SH3GLB1/RPS27A/OPTN/ATG13/EPG5/RAF1/MAP2K1/PIK3CD/DAPK2/HMGB1/RPS6KB1/ATG2A	4.35194317079796
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	33/910	170/9376	2.00005171299289	RUNX1/PPP2R2B/MSN/RAB8B/MYL12A/ARPC2/MAPK8/PRKACB/RAP1A/DLG1/MAP3K5/PPP2R2D/RAPGEF2/ARHGEF18/PRKCE/ITGB1/MYH9/ACTR3/ARPC3/MYL12B/ARPC5/ACTR2/ACTG1/PPP2R2A/MYL6/LLGL2/ARPC5L/PRKCI/ARPC4/YBX3/ACTB/RAC1/SYMPK	4.3139850505479
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	32/910	163/9376	2.02273309512573	STAT4/NFATC2/BRAF/PRKCB/TGFB1/MAP2K4/STAT5B/STAT1/SOS1/MAPK8/JAK1/YWHAZ/RB1/TRAF3/PIK3R1/BCL2/MAPK1/TGFBR2/NFKB1/CREBBP/NFATC3/SOS2/CASP8/CREB1/YWHAB/RAF1/MAP2K1/PIK3CD/TAB2/GRB2/SMAD3/JAK2	4.31839911925944
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/910	117/9376	2.20155912463605	H2AZ2/H2AZ1/ARID2/ARID1B/H2AC20/MACROH2A1/H2AJ/BICRAL/INO80/SMARCC1/GATAD2A/EPC1/BRD9/EPC2/BPTF/BRD7/RSF1/SMARCA2/PBRM1/MORF4L1/ACTG1/TRRAP/MBD2/BAZ1A/ACTB	4.2876886040682
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	37/910	203/9376	1.87794077843339	FYN/RAP1B/BRAF/PRKCB/ITGA4/SOS1/MYL12A/RAPGEF1/MAPK8/VAV3/RAP1A/PIK3R1/BCL2/DIAPH1/MAPK1/PPP1CA/GSK3B/ITGB1/PXN/CCND3/PDGFD/MYL12B/FLNA/SOS2/PPP1R12A/PPP1R12B/RAF1/MAP2K1/PIK3CD/VAV1/PAK2/ACTG1/TLN1/GRB2/ARHGAP35/ACTB/RAC1	4.14595654696955
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	58/910	368/9376	1.62388915432394	MT-ND3/ATP5F1E/PPP3CC/NUP98/RANBP2/PPP3CA/RAB1A/AMBRA1/PFN1/MAP3K5/BCL2/NDUFB1/MT-ATP8/NUP153/COX7C/NDUFB2/NDUFA4/DCTN4/RB1CC1/COX6C/EIF2AK3/HNRNPA1/COX7A2/SETX/PSMA7/UQCRB/NUP88/OPTN/PPP3CB/MATR3/SEM1/ATG13/PSMB7/UQCRFS1/NUP133/NDUFS6/SEC13/NDUFAB1/PSMB1/PSMD7/MCU/TNFRSF1B/COX7B/ACTG1/ATP5PB/COX4I1/HNRNPA3/NDUFV1/NUP214/ACTR10/DCTN5/NCBP1/PSMA4/NDUFA1/ATG2A/ACTB/RAC1/NUP210	4.00298865081115
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	37/910	204/9376	1.86873518638225	BRAF/PRKCB/TGFB1/MSN/SOS1/LUM/PRKACB/VAV3/PIK3R1/DCN/CAMK2D/MAPK1/PPP1CA/ITGB1/PXN/CD44/IQGAP1/RRAS2/FLNA/SOS2/PDCD4/ITPR1/PPP1R12A/PPP1R12B/RAF1/MAP2K1/PIK3CD/VAV1/ACTG1/ANK3/FRS2/GRB2/RPS6KB1/CBL/ITPR2/ACTB/RAC1	4.1128007975276
Organismal Systems	Immune system	hsa04611	Platelet activation	26/910	126/9376	2.12607709750567	FYN/PIK3R5/RAP1B/APBB1IP/GNAQ/STIM1/MYL12A/PRKACB/RASGRP1/RAP1A/PIK3R1/MAPK1/PPP1CA/GNA13/ITGB1/MYL12B/PLCB1/ITPR1/PPP1R12A/PIK3CD/ACTG1/TLN1/ITPR2/PRKCI/ARHGAP35/ACTB	4.17205220600413
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	25/910	122/9376	2.11133129165916	NCOA1/PRKCB/NCOA2/STAT1/FOXO1/PRKACB/PIK3R1/NCOR1/MED13L/MAPK1/GSK3B/CREBBP/KAT2B/ATP1B3/MED4/PLCB1/MED14/NCOA3/MED27/MED30/RAF1/MAP2K1/PIK3CD/ACTG1/ACTB	4.05066113411433
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	30/910	158/9376	1.9563221588538	STAG1/PPP2R5C/TGFB1/CCNH/NIPBL/CDK6/TFDP2/YWHAZ/STAG2/RB1/GSK3B/CREBBP/PPP2R5A/CCND3/PDS5B/CDC27/PPP2R5E/CDC14A/PDS5A/YWHAB/CUL1/PRKDC/ATRX/WAPL/ZBTB17/ATM/ABL1/SMC1B/RBX1/SMAD3	3.9744918682904
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	35/910	196/9376	1.83987441130298	GNG2/PIK3R5/NFATC2/PPP3CC/MAP2K4/STAT1/CDK6/MAPK8/PPP3CA/GNB1/JAK1/RB1/TRAF3/PIK3R1/CLEC2B/MAPK1/GSK3B/NFKB1/CREBBP/NFATC3/UBA52/CASP8/ITPR1/CREB1/CALM1/RPS27A/PPP3CB/PREX1/RAF1/MAP2K1/PIK3CD/IFNGR1/ITPR2/JAK2/RAC1	3.89572459364756
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	32/910	174/9376	1.89485916382468	MARCHF6/MAPK8/DNAJC1/MAP3K5/MAN1A1/BCL2/PDIA3/SEC24B/UBE2G1/EIF2AK3/CUL1/DNAJC3/FBXO6/SSR4/PDIA6/RAD23B/PLAA/SEC13/SEC61G/SEC31A/SIL1/NPLOC4/RBX1/TRAM1/NFE2L2/TMEM258/SEC23B/EDEM3/DAD1/SEC63/MAN1A2/UBE2D2	3.90620833005316
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	22/910	103/9376	2.20070415021871	PPP2R5C/PPP2R2B/RNGTT/MSI2/PPP2R2D/PPP1CA/PPP2R5A/PPP2R3A/SMG6/PPP2R5E/SMG7/PAPOLA/WDR33/HBS1L/SRRM1/RNMT/GSPT1/PPP2R2A/PPP2R3C/NCBP1/MAGOH/SYMPK	4.0170912452621
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/910	133/9376	2.01417830290011	GNG2/PPP2R5C/PRKCB/PPP2R2B/PPP3CC/GNAQ/MAPK8/PPP3CA/GNB1/PRKACB/CAMK2D/PPP2R2D/PPP1CA/GSK3B/PPP2R5A/PLCB1/PPP2R3A/ITPR1/PPP2R5E/CREB1/CALM1/PPP3CB/SLC18A2/PPP2R2A/PPP2R3C/ITPR2	3.86189855409087
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/910	193/9376	1.8150885384046	GNG2/PIK3R5/RAP1B/BRAF/PRKCB/ELMO1/STAT5B/STAT1/SOS1/GRK5/GNAQ/CX3CR1/GNB1/ITK/PRKACB/VAV3/DOCK2/RAP1A/PIK3R1/MAPK1/GSK3B/NFKB1/PXN/PLCB1/SOS2/XCL2/PREX1/RAF1/MAP2K1/PIK3CD/VAV1/GRB2/JAK2/RAC1	3.75109748457199
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/910	224/9376	1.74788069073783	NFATC2/CD3G/TGFB1/PPP3CC/MAP2K4/STAT5B/ETS1/MAPK8/PPP3CA/JAK1/RB1/PRKACB/PIK3R1/DLG1/ITGAL/RELB/MAPK1/TGFBR2/CD3D/NFKB1/CREBBP/KAT2B/CCND3/POLB/NFATC3/CDC27/CD3E/CREB1/PPP3CB/IL2RB/MAP2K1/PIK3CD/ATM/CRTC1/TLN1/XPO1/TRRAP/SMAD3	3.71420205723732
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	39/910	235/9376	1.70990881458967	MT-ND3/ATP5F1E/ARID1B/SOS1/RPS6KA3/PRKACB/RPTOR/MAP3K5/NDUFB1/MT-ATP8/COX7C/NDUFB2/NDUFA4/COX6C/SOS2/SMARCC1/COX7A2/COA1/CREB1/UQCRB/SMARCA2/ATP5ME/UQCRFS1/NDUFAF2/NDUFS6/NDUFAB1/CPT1A/NDUFAF6/COX7B/ACTG1/COX14/ATP5PB/FRS2/GRB2/COX4I1/RPS6KB1/NDUFV1/NDUFA1/ACTB	3.61332351659231
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/910	308/9376	1.60570857713715	MT-ND3/ATP5F1E/RCOR1/NRF1/GNAQ/MAPK8/AMBRA1/MAP3K5/NDUFB1/POLR2L/MT-ATP8/COX7C/CREBBP/NDUFB2/NDUFA4/DCTN4/POLR2B/RB1CC1/PLCB1/COX6C/AP2B1/COX7A2/CASP8/ITPR1/CREB1/POLR2G/PSMA7/UQCRB/SEM1/ATG13/PSMB7/UQCRFS1/HIP1/NDUFS6/NDUFAB1/PSMB1/PSMD7/COX7B/HTT/ATP5PB/COX4I1/NDUFV1/ACTR10/DCTN5/PSMA4/NDUFA1/ATG2A/TAF4B	3.54364761339834
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/910	69/9376	2.38917025003982	FYN/MAP2K4/SOS1/MAPK8/VAV3/PIK3R1/MAPK1/SOS2/ALOX5AP/GAB2/RAF1/MAP2K1/PIK3CD/VAV1/GRB2/RAC1	3.79701545410459
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	68/910	480/9376	1.4596336996337	MT-ND3/ATXN1/BRAF/PRKCB/ATP5F1E/PPP3CC/GNAQ/MAPK8/PPP3CA/RAB1A/AMBRA1/MAP3K5/CAMK2D/BCL2/NDUFB1/MT-ATP8/MAPK1/GSK3B/COX7C/NFKB1/NDUFB2/NDUFA4/UBE2G1/DCTN4/RB1CC1/PLCB1/COX6C/EIF2AK3/DKK1/COX7A2/UBA52/CASP8/ITPR1/PSEN1/CALM1/RPS27A/PSMA7/UQCRB/OPTN/PPP3CB/SEM1/ATG13/PARK7/PSMB7/UQCRFS1/HIP1/RAF1/NDUFS6/MAP2K1/NDUFAB1/PSMB1/PSMD7/MCU/TNFRSF1B/COX7B/HTT/ATP5PB/UBE2L3/CSNK2A1/COX4I1/NDUFV1/ACTR10/DCTN5/ITPR2/PSMA4/NDUFA1/ATG2A/RAC1	3.38923979328988
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/910	77/9376	2.27475381761096	BRAF/TGFB1/STAT1/CDK6/MAPK8/JAK1/RB1/PIK3R1/MAPK1/TGFBR2/NFKB1/RAF1/MAP2K1/PIK3CD/RPS6KB1/SMAD3/RAC1	3.68231351816389
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	26/910	142/9376	1.88651911468813	FYN/NFATC2/TGFB1/PPP3CC/CAMK4/STAT1/MAPK8/PPP3CA/JAK1/CYBA/PIK3R1/RELB/MAPK1/TGFBR2/NFKB1/ITPR1/CREB1/GAB2/PPP3CB/MAP2K1/PIK3CD/IFNGR1/TAB2/GRB2/ITPR2/RAC1	3.48983218375092
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	43/910	275/9376	1.61106093906094	FYN/MT-ND3/ATP5F1E/PPP3CC/MAPK8/PPP3CA/PRKACB/CYBA/PIK3R1/NDUFB1/MT-ATP8/MAPK1/GSK3B/COX7C/NDUFB2/NDUFA4/COX6C/EIF2AK3/COX7A2/ITPR1/CREB1/NCAM1/PSMA7/UQCRB/PPP3CB/SEM1/PSMB7/UQCRFS1/NDUFS6/NDUFAB1/PSMB1/PIK3CD/PSMD7/MCU/COX7B/ATP5PB/CSNK2A1/COX4I1/NDUFV1/ITPR2/PSMA4/NDUFA1/RAC1	3.37189090695205
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	37/910	227/9376	1.6793919736651	MT-ND3/BRAF/PTPRJ/ATP5F1E/MAP2K4/SOS1/MAPK8/CYBA/PIK3R1/MAP3K5/NDUFB1/MT-ATP8/MAPK1/COX7C/NFKB1/NDUFB2/NDUFA4/COX6C/SOS2/COX7A2/UQCRB/UQCRFS1/RAF1/NDUFS6/MAP2K1/NDUFAB1/PIK3CD/ABL1/COX7B/ATP5PB/GRB2/COX4I1/NDUFV1/NFE2L2/PTPN1/NDUFA1/RAC1	3.39714222067063
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	26/910	144/9376	1.86031746031746	ATXN1/PRKCB/PUM2/GNAQ/MAPK8/AMBRA1/PIK3R1/MAP3K5/PUM1/RB1CC1/PLCB1/OPA1/RORA/ITPR1/PSMA7/SEM1/ATG13/PSMB7/PSMB1/PIK3CD/ATXN10/PSMD7/MCU/ITPR2/PSMA4/ATG2A	3.41082382184947
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/910	115/9376	1.97106545628285	BRAF/AKAP13/PRKCB/PDE4D/GNAQ/PRKACB/STK39/BCL2/MAPK1/OXSR1/PDE4A/GNA13/PLCB1/ITPR1/CREB1/WNK1/MMP24/RAF1/MAP2K1/NACA/PDE4B/ITPR2	3.43507074387172
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/910	73/9376	2.25825681168147	EML4/BRAF/PRKCB/STAT5B/SOS1/CDK6/RB1/PIK3R1/MAPK1/STK4/SOS2/RAF1/MAP2K1/PIK3CD/RASSF1/GRB2	3.53823286418146
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	17/910	80/9376	2.18945054945055	BRAF/PRKCB/SOS1/JAK1/PIK3R1/BCL2/MAPK1/GSK3B/NF1/PDGFD/SOS2/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1/JAK2	3.50276119306214
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/910	138/9376	1.86653925784361	PPP2R5C/PPP3CC/RPS6KA3/PPP3CA/YWHAZ/PRKACB/CAMK2D/FBXW11/MAPK1/PPP1CA/PPP2R5A/CDC27/BTRC/ITPR1/PPP2R5E/CALM1/YWHAB/CUL1/PPP3CB/SPDYE2/MAP2K1/SMC1B/RBX1/SPDYE18/ITPR2	3.36206425550444
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/910	138/9376	1.86653925784361	CBLB/BRAF/PDE3B/SOS1/RAPGEF1/MAPK8/FOXO1/PRKACB/PIK3R1/RPTOR/MAPK1/PPP1CA/GSK3B/SOS2/PRKAR2A/CALM1/PHKB/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1/CBL/PTPN1/PRKCI	3.36206425550444
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/910	116/9376	1.9540735126942	RAP1B/PRKCB/MSN/ITGA4/RHOH/MYL12A/ITK/VAV3/CYBA/RAP1A/PIK3R1/ITGAL/CD99/ITGB1/PXN/MYL12B/PIK3CD/VAV1/ACTG1/ARHGAP35/ACTB/RAC1	3.38978803604203
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	33/910	200/9376	1.70004395604396	FYN/CYTH1/ARPC2/MYO1F/MAPK8/RAB1A/CYFIP2/MAPK1/SEC24B/WIPF1/NFKB1/MYO1D/GNA13/ITGB1/MYH9/ACTR3/ARPC3/ABI1/ARPC5/CASP8/MYO5A/TMED10/ACTR2/NCK1/ABL1/PAK2/ACTG1/TAB2/ARPC5L/CYTH3/ARPC4/ACTB/RAC1	3.28080794560301
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/910	139/9376	1.85311091785912	NCOA1/NCOA2/ESR2/SOS1/GNAQ/PRKACB/PIK3R1/BCL2/MAPK1/PLCB1/KRT24/SOS2/NCOA3/ITPR1/OPRM1/CREB1/CALM1/RAF1/MAP2K1/PIK3CD/GRB2/ITPR2/KRT14/KRT10/KRT17	3.32211475857343
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	45/910	300/9376	1.54549450549451	RAP1B/BRAF/PRKCB/TGFB1/RASA2/PPP3CC/MAP2K4/SOS1/RPS6KA3/MAPK8/PPP3CA/RPS6KA5/PRKACB/RASGRP1/MAP3K2/MAP3K8/RAP1A/RASA1/MAP3K5/TAOK3/RELB/RAPGEF2/MAPK1/TGFBR2/NFKB1/NF1/PDGFD/RRAS2/FLNA/NFATC3/STK4/SOS2/MAP4K4/PPP3CB/RAF1/MAP4K3/MAP2K1/TAOK1/NLK/PAK2/MAX/TAB2/GRB2/EFNA5/RAC1	3.14826271872994
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/910	268/9376	1.57625061505659	MT-ND3/ATP5F1E/MAPK8/PRKACB/MAP3K5/CAMK2D/NDUFB1/MT-ATP8/COX7C/NDUFB2/NDUFA4/UBE2G1/COX6C/EIF2AK3/COX7A2/UBA52/ITPR1/CALM1/RPS27A/PSMA7/UQCRB/SEM1/PARK7/PSMB7/UQCRFS1/NDUFS6/NDUFAB1/SLC18A2/PSMB1/PSMD7/MCU/COX7B/SLC39A11/ATP5PB/UBE2L3/COX4I1/NDUFV1/NFE2L2/ITPR2/PSMA4/NDUFA1	3.1378666995199
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/910	76/9376	2.16911509543088	BRAF/PRKCB/CAMK1D/CAMK4/SOS1/CDK6/RB1/PIK3R1/CAMK2D/MAPK1/SOS2/CALM1/RAF1/MAP2K1/PIK3CD/GRB2	3.35497889289056
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/910	105/9376	1.96253270538985	CBLB/NFATC2/PPP3CC/STAT1/MAPK8/PPP3CA/PIK3R1/RELB/MAPK1/NFKB1/MALT1/RRAS2/NFATC3/CASP8/ITPR1/CALM1/PPP3CB/RAF1/PIK3CD/ITPR2	3.25172684494365
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	33/910	205/9376	1.65857946931118	MT-ND3/PRKCB/TGFB1/ATP5F1E/MAPK8/CYBA/PIK3R1/CAMK2D/NDUFB1/MT-ATP8/PPP1CA/TGFBR2/GSK3B/COX7C/NFKB1/NDUFB2/NDUFA4/PLCB1/COX6C/COX7A2/UQCRB/PDK3/UQCRFS1/NDUFS6/NDUFAB1/PIK3CD/COX7B/ATP5PB/COX4I1/NDUFV1/NDUFA1/SMAD3/RAC1	3.12567611369461
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/910	98/9376	1.99757793227181	PRKCB/INPP4B/PIP4K2A/PIK3R1/PI4KA/INPP4A/ITPKB/PLCB1/MTMR3/ITPR1/BPNT2/CDS2/CALM1/PI4K2B/PIK3CD/SYNJ1/PIK3C2A/ITPR2/SACM1L	3.25461700659954
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	37/910	238/9376	1.60177301689907	GNG2/RAP1B/PRKCB/RASA2/RALGAPA1/PLAAT2/ETS1/SOS1/MAPK8/GNB1/PRKACB/RASGRP1/RAP1A/PIK3R1/RASA1/MAPK1/NFKB1/EXOC2/NF1/PDGFD/RRAS2/STK4/SOS2/CALM1/SHOC2/GAB2/RALGAPA2/RAF1/MAP2K1/PIK3CD/ABL1/PAK2/RASSF1/GRB2/EFNA5/RALGAPB/RAC1	3.08292396919421
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	15/910	71/9376	2.17675282464015	STAT5B/ESR2/STAT1/SOS1/MAPK8/PIK3R1/MAPK1/GSK3B/NFKB1/SOS2/RAF1/MAP2K1/PIK3CD/GRB2/JAK2	3.26304781203171
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/910	107/9376	1.9258498510835	PPP3CC/PDE3B/SIK1/SIK2/GNAQ/PPP3CA/FOXO1/PRKACB/CAMK2D/PPP4R3A/CREBBP/PLCB1/ITPR1/CREB1/CALM1/PPP4R3B/PPP3CB/PHKB/CPT1A/ITPR2	3.15778975289363
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/910	122/9376	1.85797153666006	PRKCB/MAP2K4/STAT5B/STAT1/SOS1/GNAQ/MAPK8/PRKACB/PIK3R1/MAPK1/GSK3B/CREBBP/PLCB1/SOS2/ITPR1/CREB1/RAF1/MAP2K1/PIK3CD/GRB2/ITPR2/JAK2	3.12719706878471
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/910	108/9376	1.90801790801791	NUP98/RANBP2/NUP153/XPO4/KPNA1/KPNA6/XPO6/NUP88/SENP2/NUP133/SEC13/KPNA3/SRRM1/XPO1/NUP214/THOC2/NCBP1/AHCTF1/MAGOH/NUP210	3.11157648878063
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	26/910	154/9376	1.73951762523191	PIK3R5/NFATC2/PRKCB/CAMK1D/PPP3CC/CAMK4/GNAQ/PPP3CA/PRKACB/CAMK2D/MAPK1/PPP1CA/PLCB1/NFATC3/ITPR1/PPP1R12A/CALM1/PPP3CB/PPP1R12B/RAF1/MAP2K1/ACTG1/MYL6/ITPR2/CD38/ACTB	3.03363644361089
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/910	87/9376	2.01328786156372	BRAF/TGFB1/SOS1/MAPK8/PIK3R1/BCL2/MAPK1/TGFBR2/GSK3B/SOS2/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1/SMAD3/RAC1	3.11297180598149
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/910	227/9376	1.58861402914266	GNG2/NFATC2/AKAP13/PRKCB/PPP3CC/SOS1/GNAQ/CDK6/PPP3CA/GNB1/JAK1/RB1/PRKACB/PIK3R1/MAPK1/PDIA3/GSK3B/NFKB1/GNA13/PXN/PLCB1/NFATC3/SOS2/CASP8/ITPR1/CREB1/CALM1/PPP3CB/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1/ITPR2/RAC1	2.94322813278521
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/910	388/9376	1.43396397417016	MT-ND3/BRAF/ATP5F1E/PPP3CC/GNAQ/MAPK8/PPP3CA/AMBRA1/PIK3R1/MAP3K5/NDUFB1/MT-ATP8/MAPK1/GSK3B/COX7C/NFKB1/NDUFB2/NDUFA4/ADAM10/RB1CC1/PLCB1/COX6C/EIF2AK3/DKK1/COX7A2/CASP8/ITPR1/PSEN1/CALM1/PSMA7/UQCRB/PPP3CB/SEM1/ATG13/PSMB7/UQCRFS1/RAF1/NDUFS6/MAP2K1/NDUFAB1/PSMB1/PIK3CD/PSMD7/MCU/COX7B/SLC39A11/ATP5PB/CSNK2A1/COX4I1/NDUFV1/ITPR2/PSMA4/NDUFA1/ATG2A	2.86223449185599
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/910	34/9376	2.7273432449903	CRY1/FBXW11/NR1D2/RORA/BTRC/BHLHE40/CREB1/CUL1/RBX1	3.30799904343126
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/910	103/9376	1.90060812973434	CD3G/CD247/PPP2R2B/TGFB1/MAP2K4/GNAQ/MAPK8/PIK3R1/PPP2R2D/MAPK1/TGFBR2/CD3D/NFKB1/PLCB1/CASP8/CD3E/PIK3CD/IFNGR1/PPP2R2A	3.01308614008597
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	32/910	205/9376	1.60831948539266	H4C3/RASA2/STAT5B/CDK6/JAK1/YWHAZ/RB1/PRKACB/TRAF3/PIK3R1/DLG1/MAPK1/UBR4/NFKB1/CREBBP/KAT2B/HDAC4/PXN/CCND3/POLB/SND1/CASP8/UBE3A/CREB1/YWHAB/GTF2E2/SP100/GTF2A2/PIK3CD/HDAC9/GRB2/RAC1	2.88713780734093
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/910	83/9376	1.98617767774394	SFMBT2/AUTS2/JARID2/MBD5/KDM2B/PCGF5/LCOR/PHC3/FOXK2/CREBBP/SCMH1/OGT/ASXL2/MAX/YAF2/UBE2D2	2.95858089110321
Human Diseases	Infectious disease: viral	hsa05162	Measles	23/910	136/9376	1.74246929541047	CBLB/CD3G/MSN/STAT5B/STAT1/CDK6/MAPK8/JAK1/TRAF3/PIK3R1/BCL2/CD3D/GSK3B/NFKB1/CCND3/TNFAIP3/CASP8/CD3E/IL2RB/PIK3CD/EIF3H/TAB2/CSNK2A1	2.8594280234831
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	19/910	106/9376	1.84681733360979	BRAF/ZEB1/SOS1/FOXO1/RB1/PIK3R1/BCL2/MAPK1/GSTP1/GSK3B/NFKB1/CREBBP/PDGFD/SOS2/CREB1/RAF1/MAP2K1/PIK3CD/GRB2	2.87455092492689
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	28/910	178/9376	1.62074330164218	NFATC2/PRKCB/PPP3CC/MAPK8/PPP3CA/TBL1X/PRKACB/CAMK2D/TBL1XR1/FBXW11/GSK3B/CREBBP/CCND3/CCDC88C/PLCB1/NFATC3/DKK1/BTRC/PSEN1/CUL1/INVS/PPP3CB/SENP2/NLK/CSNK2A1/RBX1/SMAD3/RAC1	2.74121148455339
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/910	170/9376	1.63640594699418	BRAF/PRKCB/TGFB1/ARID2/ARID1B/SOS1/CDK6/RB1/PIK3R1/MAPK1/GSTP1/TGFBR2/GSK3B/SOS2/SMARCC1/BRD7/SMARCA2/RAF1/MAP2K1/PBRM1/PIK3CD/ACTG1/GRB2/RPS6KB1/NFE2L2/SMAD3/ACTB	2.74530377353816
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	20/910	115/9376	1.79187768752986	FYN/GNG2/PIK3R5/PRKCB/CAMK4/GNAQ/GNB1/PRKACB/PIK3R1/CAMK2D/BCL2/MAPK1/KCNQ5/PLCB1/ITPR1/CREB1/MAP2K1/PIK3CD/ITPR2/JAK2	2.8012075391613
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/910	93/9376	1.883398322108	PRKCB/MAP2K4/SOS1/GNAQ/MAPK8/PRKACB/MAP3K2/CAMK2D/MAPK1/PLCB1/SOS2/ITPR1/CALM1/RAF1/MAP2K1/GRB2/ITPR2	2.80686206727624
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/910	212/9376	1.55521459672403	SKAP1/RAP1B/BRAF/PRKCB/APBB1IP/GNAQ/RAPGEF1/SIPA1L1/VAV3/EVL/RAP1A/PIK3R1/PFN1/ITGAL/RAPGEF2/MAPK1/ITGB1/FYB1/PDGFD/PLCB1/CALM1/SIPA1L3/RAF1/MAP2K1/PIK3CD/VAV1/ACTG1/TLN1/EFNA5/PRKCI/ACTB/RAC1	2.68073242736556
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/910	101/9376	1.83623109563704	PRKCB/TGFB1/STAT5B/STAT1/MAPK8/FOXO1/PIK3R1/BCL2/DIAPH1/MAPK1/TGFBR2/PRKCE/NFKB1/PLCB1/PIK3CD/SMAD3/JAK2/RAC1	2.77011145376973
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/910	73/9376	1.97597471022129	RANBP2/NUP153/CREBBP/KAT2B/CCNT1/SERINC5/VPS4B/MLLT3/CCNT2/PDCD6IP/SAMHD1/ELL2/XPO1/APOBEC3C	2.74445229483814
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/910	60/9376	2.06065934065934	NFATC2/PRKCB/PPP3CC/PPP3CA/PIK3R1/MAPK1/PXN/PPP3CB/RAF1/MAP2K1/PIK3CD/RAC1	2.70211612079713
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	18/910	105/9376	1.76627943485086	ARIH1/USP15/MAPK8/AMBRA1/TAX1BP1/MARCHF5/RAB7A/SMURF2/HUWE1/RRAS2/OPA1/EIF2AK3/UBA52/TBC1D15/TOMM7/RPS27A/OPTN/CSNK2A1	2.58872388967146
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/910	137/9376	1.65454399614984	GZMB/CTSW/PRF1/MAPK8/PIK3R1/MAP3K5/BCL2/MAPK1/NFKB1/EIF2AK3/PARP4/CASP8/ITPR1/CTSS/RAF1/MAP2K1/PIK3CD/ATM/ACTG1/CTSC/ITPR2/ACTB	2.53019414216698
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/910	68/9376	1.96974789915966	RUNX1/BRAF/STAT5B/SOS1/PIK3R1/MAPK1/NFKB1/SOS2/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1	2.63119065946981
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/910	138/9376	1.64255454690237	MT-ND3/ATP5F1E/NDUFB1/MT-ATP8/COX7C/NDUFB2/NDUFA4/COX6C/COX7A2/UQCRB/ATP5ME/UQCRFS1/NDUFS6/NDUFAB1/COX7B/ATP5PB/COX4I1/NDUFV1/ATP6V1H/ATP6V1G1/NDUFA1/PPA2	2.49303150988021
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	34/910	238/9376	1.47189952904239	PRKCB/RPS21/RPL37/RPS26/STAT1/RPL39/RPL37A/MAPK8/JAK1/TRAF3/RPS27/PIK3R1/RPL34/RPS29/RPS28/MAPK1/NFKB1/RPL27A/RPL6/UBA52/RPL38/RPS4X/RPL35A/RPS27A/RPS8/RPL36/RPS24/RPS10-NUDT3/RPS7/PIK3CD/RPL30/TAB2/RPL21/RPL7	2.41757328474607
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/910	99/9376	1.76925296925297	BRAF/ESR2/SOS1/MAPK8/RB1/PRKACB/PIK3R1/NCOR1/BCL2/MAPK1/SOS2/NCOA3/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1	2.5226105201442
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/910	99/9376	1.76925296925297	GPCPD1/PRKCB/SOS1/MAPK8/PIK3R1/MAPK1/PDGFD/SOS2/RAF1/MAP2K1/PIK3CD/PLPP1/GRB2/SLC44A2/RPS6KB1/RAC1/CHKA	2.5226105201442
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	30/910	205/9376	1.50779951755561	CD3G/CD247/RUNX3/MAP2K4/STAT1/CDK6/MAPK8/JAK1/RB1/TRAF3/PIK3R1/ITGAL/BCL2/RELB/PDIA3/CD3D/NFKB1/CCND3/CD44/CIR1/TNFAIP3/CASP8/CD3E/NCOR2/SEM1/PIK3CD/PSMD7/CD58/TAB2/RAC1	2.41006119463356
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/910	156/9376	1.58512256973795	BRAF/PPP2R2B/PIAS1/STAT1/SOS1/CDK6/JAK1/YWHAZ/RB1/TRAF3/PIK3R1/PPP2R2D/MAPK1/GSK3B/NFKB1/SOS2/CASP8/YWHAB/RAF1/MAP2K1/PIK3CD/EIF3E/GRB2/PPP2R2A	2.41607766872429
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	24/910	157/9376	1.57502624763771	TGFB1/MAPK8/PIK3R1/MAP3K5/NDUFB1/GSK3B/COX7C/NFKB1/NDUFB2/NDUFA4/COX6C/EIF2AK3/COX7A2/CASP8/UQCRB/UQCRFS1/NDUFS6/NDUFAB1/PIK3CD/COX7B/COX4I1/NDUFV1/NDUFA1/RAC1	2.38211536261287
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	31/910	216/9376	1.47871387871388	NFATC2/RAP1B/PPP3CC/MAP2K4/MAPK8/PPP3CA/VAV3/TRAF3/CYBA/RAP1A/PIK3R1/MAP3K5/CAMK2D/BCL2/MAPK1/GSK3B/NFKB1/PLCB1/NFATC3/EIF2AK3/CASP8/ITPR1/POU2F1/CALM1/PPP3CB/PIK3CD/VAV1/TAB2/NFE2L2/JAK2/RAC1	2.33357820328745
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	11/910	56/9376	2.02386185243328	B4GALT1/MAN1A1/MGAT4A/FUT8/MGAT5/MAN2A1/ST6GAL1/DHRSX/TMEM258/DAD1/MAN1A2	2.51938547824309
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	27/910	184/9376	1.51189679885332	FYN/NFATC2/SSH2/PPP3CC/ABLIM1/MYL12A/PPP3CA/PIK3R1/RASA1/CAMK2D/MAPK1/GSK3B/SEMA4D/ITGB1/MYL12B/NFATC3/BMPR2/RGS3/PPP3CB/CFL1/RAF1/PIK3CD/NCK1/ABL1/PAK2/EFNA5/RAC1	2.29907701524803
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	23/910	154/9376	1.53880405308977	PIK3R5/PPP2R5C/PPP2R2B/GNAQ/RPS6KA5/PRKACB/ATP2B1/ATP2B4/CAMK2D/BCL2/PPP2R2D/MAPK1/PPP1CA/ATP1B3/PPP2R5A/PLCB1/PPP2R3A/PPP2R5E/TPM3/CREB1/CALM1/PPP2R2A/PPP2R3C	2.21027269080407
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/910	31/9376	2.32655086848635	SPCS2/SRP14/IMMP2L/SPCS1/SEC61G/SEC11C/SEC63	2.4253940321885
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/910	173/9376	1.48891570856889	RAB11A/PRKCB/STAT1/NUP98/CDK6/JAK1/TRAF3/PIK3R1/HNRNPUL1/MAPK1/NFKB1/CREBBP/CCND3/KPNA1/CASP8/KPNA6/DNAJC3/RAF1/MAP2K1/PIK3CD/ACTG1/IFNGR1/XPO1/JAK2/ACTB	2.12794076263318
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/910	140/9376	1.54549450549451	GNG2/PIK3R5/CAMK4/PDE3B/NRF1/GNAQ/GNB1/PRKACB/MAPK1/PRKCE/GNA13/HDAC4/RRAS2/PLCB1/ITPR1/CALM1/RAF1/MAP2K1/RPS6KB1/ITPR2/SMAD3	2.13196287840339
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/910	53/9376	1.94401824590504	RAB11A/PRKCB/GNAQ/PRKACB/ATP2B1/ATP2B4/ATP1B3/PLCB1/AP2B1/DNM2	2.25947574362641
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	43/910	333/9376	1.33045573045573	PPP2R5C/PPP2R2B/ITGA4/MAML2/STAT1/SOS1/CDK6/FOXO1/JAK1/RB1/PRKACB/TRAF3/PIK3R1/DLG1/PPP2R2D/MAPK1/UBR4/GSK3B/NFKB1/CREBBP/ITGB1/PXN/PPP2R5A/CCND3/PPP2R3A/SOS2/CASP8/PSEN1/UBE3A/PPP2R5E/CREB1/RAF1/MAP2K1/PIK3CD/ATM/GRB2/RPS6KB1/PPP2R2A/ATP6V1H/PPP2R3C/LLGL2/ATP6V1G1/PRKCI	2.01301189435021
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/910	109/9376	1.60693618308297	PRKCB/PRKCQ/RPS6KA3/MAPK8/FOXO1/PIK3R1/PPP1CA/GSK3B/PRKCE/NFKB1/OGA/CREB1/OGT/PIK3CD/CPT1A/RPS6KB1/PTPN1	2.08955544278905
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/910	134/9376	1.53780547810399	PRKCH/BRAF/PRKCB/PRKCQ/GNAQ/PRKACB/MAPK1/PPP1CA/PRKCE/GNA13/MYH9/PLCB1/ITPR1/PPP1R12A/CALM1/PPP1R12B/RAF1/MAP2K1/MYL6/ITPR2	2.05570996458178
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	13/910	78/9376	1.71721611721612	INPP4B/PIP4K2A/PI4KA/INPP4A/ITPKB/PLCB1/MTMR3/PI4K2B/INPP5K/PIK3CD/SYNJ1/PIK3C2A/SACM1L	2.08530590552142
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/910	78/9376	1.71721611721612	CNOT6L/PAN3/XRN1/CNOT2/ZCCHC7/TENT4B/C1D/DDX6/CNOT1/XRN2/CNOT10/MTREX/CNOT4	2.08530590552142
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	27/910	195/9376	1.42661031276416	H3-3A/H3-3B/H2AZ2/H2AZ1/PRKCB/H4C3/H2AC20/MACROH2A1/H2AJ/CYBA/PIK3R1/ITGAL/MAPK1/ATG7/NFKB1/HDAC4/PLCB1/SELPLG/RAF1/MAP2K1/PIK3CD/HDAC9/ACTG1/H3C4/HMGB1/ACTB/RAC1	1.97365329520707
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/910	41/9376	2.01039935674082	BRAF/RPS6KA5/RB1/MAPK1/RAF1/MAP2K1/DAPK2/RASSF1	2.12566602205693
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/910	65/9376	1.74363482671175	PRKCB/ESR2/GNAQ/PIK3R1/MAPK1/PLCB1/ITPR1/RAF1/MAP2K1/PIK3CD/ITPR2	1.97235660238183
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	14/910	89/9376	1.62074330164218	PRKCB/SOS1/GNAQ/PRKACB/MAP3K2/MAPK1/PDGFD/PLCB1/SOS2/ITPR1/RAF1/MAP2K1/GRB2/ITPR2	1.92901908617423
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/910	226/9376	1.36769425265001	RAP1B/BRAF/PDE4D/CAMK4/PDE3B/MAPK8/PRKACB/VAV3/ATP2B1/RAP1A/PIK3R1/ATP2B4/CAMK2D/MAPK1/PPP1CA/NFKB1/PDE4A/CREBBP/ATP1B3/RRAS2/PPP1R12A/CREB1/CALM1/ABCC4/RAF1/MAP2K1/PIK3CD/VAV1/PDE4B/RAC1	1.83441552135673
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/910	191/9376	1.40254300673149	H3-3A/H3-3B/GNG2/H2AZ2/H2AZ1/BRAF/H4C3/CAMK4/H2AC20/MACROH2A1/SOS1/H2AJ/GNB1/PRKACB/MAPK1/PPP1CA/HDAC4/SOS2/CREB1/CALM1/RAF1/MAP2K1/SLC18A2/HDAC9/H3C4/GRB2	1.84270829892256
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/910	98/9376	1.57703520968827	PRKCB/CAMK1D/CAMK4/GNAQ/PRKACB/ATP2B1/ATP2B4/CAMK2D/PRKCE/ATP1B3/PLCB1/ITPR1/CREB1/CALM1/ITPR2	1.88258836337859
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/910	166/9376	1.42756520587846	PIK3R5/NFATC2/PPP3CC/PDE3B/GNAQ/PPP3CA/ATP2B1/ATP2B4/MAPK1/PPP1CA/PRKCE/GNA13/ATP1B3/PLCB1/NFATC3/ITPR1/PPP1R12A/CREB1/CALM1/PPP3CB/RAF1/MAP2K1/ITPR2	1.82219053920656
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/910	149/9376	1.4521424883841	FYN/PIK3R5/CYTH1/SOS1/PIK3R1/MAPK1/GNA13/AGPAT4/PDGFD/RRAS2/PLCB1/SOS2/DNM2/GAB2/AGPAT3/RAF1/MAP2K1/PIK3CD/PLPP1/GRB2/CYTH3	1.82391836528857
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	22/910	158/9376	1.43463624982612	BRAF/PRKCB/SOS1/RPS6KA3/PIK3R1/RPTOR/MAPK1/RICTOR/GSK3B/SLC7A5/SOS2/MAPKAP1/PRR5L/RAF1/SEC13/MAP2K1/PIK3CD/LPIN2/GRB2/RPS6KB1/ATP6V1H/ATP6V1G1	1.80635596969603
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/910	99/9376	1.56110556110556	PRKCH/PRKCB/PRKCQ/GNAQ/MAPK8/PRKACB/PIK3R1/CAMK2D/PPP1CA/PRKCE/PLCB1/ITPR1/CALM1/PIK3CD/ITPR2	1.84003292535986
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/910	133/9376	1.47189952904239	BRAF/TGFB1/SOS1/MAPK8/FOXO1/PIK3R1/MAPK1/TGFBR2/CREBBP/STK4/SOS2/RAF1/MAP2K1/PIK3CD/NLK/ATM/C8orf44-SGK3/GRB2/SMAD3	1.79695040179188
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/910	59/9376	1.74632147513503	BRAF/SOS1/PIK3R1/MAPK1/GSK3B/SOS2/RAF1/MAP2K1/PIK3CD/GRB2	1.88530274055918
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/910	44/9376	1.87332667332667	B4GALT1/MAN1A1/MGAT4A/FUT8/MAN2A1/TMEM258/DAD1/MAN1A2	1.90363157693497
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/910	44/9376	1.87332667332667	CCNH/TAF3/GTF2F2/TAF2/MNAT1/GTF2E2/GTF2A2/TAF4B	1.90363157693497
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/910	60/9376	1.71721611721612	BRAF/PRKCB/GNAQ/MAPK1/GNA13/PLCB1/ITPR1/RAF1/MAP2K1/ITPR2	1.82716651627324
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/910	69/9376	1.64255454690237	PPP3CC/PDE3B/GNAQ/PPP3CA/PRKACB/PLCB1/ITPR1/CREB1/CALM1/PPP3CB/ITPR2	1.75629268235737
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/910	69/9376	1.64255454690237	PRKCB/PPP3CC/CAMK4/PPP3CA/PRKACB/CAMK2D/PPP1CA/CREB1/CALM1/PPP3CB/SLC18A2	1.75629268235737
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/910	78/9376	1.58512256973795	PRKCB/TGFB1/ITGA4/STAT1/JAK1/CYBA/MAPK1/NFKB1/ITGB1/IFNGR1/TAB2/JAK2	1.70124390799316
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/910	46/9376	1.79187768752986	PSME4/PSMA7/SEM1/PSMB7/POMP/PSMB1/PSMD7/PSMA4	1.76507596995629
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/910	130/9376	1.42661031276416	GNG2/TGFB1/MAP2K4/SOS1/MAPK8/GNB1/PRKACB/PIK3R1/MAPK1/TGFBR2/NFKB1/PLCB1/SOS2/CREB1/RAF1/MAP2K1/PIK3CD/GRB2	1.60580676669605
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	26/910	201/9376	1.33276474769012	H3-3A/H3-3B/GZMB/KDM6A/RUNX1/ZEB1/BCL11B/FOXO1/SUPT3H/ETV6/NCOR1/JMJD1C/TGFBR2/NFKB1/FUT8/CCNT1/FLI1/MLLT3/IL2RB/CCNT2/AFF1/ZBTB17/ATM/KLF3/MAX/H3C4	1.56350583535114
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/910	63/9376	1.63544392115821	SMYD3/KMT2E/KMT2C/CAMKMT/ASH1L/PHYKPL/SETD2/EHMT1/DLST/NSD3	1.65908984468374
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	21/910	157/9376	1.378147966683	NFATC2/ATP11B/ELMO1/TGFB1/ATP8A1/CX3CR1/CAMK2D/MAPK1/RAB7A/ADAM10/VPS8/NFATC3/CREB1/UQCRFS1/MAP2K1/ANO6/CPT1A/GPR132/JAK2/CD47/RAC1	1.56652341432581
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/910	122/9376	1.43570527832823	PPP2R5C/PPP2R2B/RAB2A/FOXO1/PIK3R1/RPTOR/PPP2R2D/PPP2R5A/PPP2R3A/RAB10/PPP2R5E/CREB1/PIK3CD/CPT1A/RPS6KB1/PPP2R2A/PPP2R3C	1.58809029323536
Cellular Processes	Cell motility	hsa04814	Motor proteins	25/910	194/9376	1.32774442052793	BICDL1/KIF13B/MYL12A/MYO1F/DYNLT1/CAPZB/CAPZA1/MYO1D/MYO9B/MYH9/DCTN4/MYL12B/TPM3/MYO5A/KIFAP3/KIF1B/DNAI3/ACTG1/MYL6/ACTR10/CAPZA2/HOOK3/DCTN5/MYO9A/ACTB	1.51228878020133
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/910	56/9376	1.65588697017268	CUL3/PRKACB/BCL2/FBXW11/GSK3B/SMURF2/BTRC/CUL1/CSNK1G3	1.61392096413671
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/910	90/9376	1.48825396825397	CAMK4/FOXO1/PRKACB/PIK3R1/RPTOR/NFKB1/RB1CC1/EHMT1/ATG5/CREB1/ATG13/PIK3CD/RPS6KB1	1.52587830771546
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/910	49/9376	1.68217089033416	B4GALT1/GALNT11/OGT/GALNT2/ST6GAL1/GALNT10/GXYLT1/POMT1	1.56959438760392
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/910	181/9376	1.309258697104	TGFB1/PPP3CC/STAT1/MAPK8/PPP3CA/JAK1/CAMK2D/BCL2/MAPK1/RAB7A/NFKB1/CREBBP/MALT1/CASP8/CREB1/CALM1/CTSS/PPP3CB/RAF1/IFNGR1/ATP6V1H/CD74/JAK2	1.3773761060759
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	15/910	110/9376	1.404995004995	TGFB1/DCN/NCOR1/MAPK1/TGFBR2/CREBBP/SMURF2/EMP3/LEMD3/BMPR2/CUL1/SKI/RPS6KB1/RBX1/SMAD3	1.4007707477568
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/910	119/9376	1.3853172038046	MAP2K4/MAPK8/RPS6KA5/TRAF3/MAP3K8/PIK3R1/MAP3K5/MAPK1/NFKB1/TNFAIP3/CASP8/CREB1/MAP2K1/PIK3CD/TNFRSF1B/TAB2	1.38683230989736
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/910	76/9376	1.49126662810873	PRKCB/GNAQ/PRKACB/CAMK2D/ATP1B3/PLCB1/ITPR1/CALM1/ACTG1/ITPR2/ACTB	1.40977494391078
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/910	102/9376	1.41417797888386	RAB11A/RAP1B/PRKCB/GNAQ/ATP2B1/RAP1A/ATP2B4/ATP1B3/PLCB1/ITPR1/RAB27B/ITPR2/CD38/RAC1	1.37886182166007
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/910	13/9376	2.37768385460693	XRCC6/XRCC5/PRKDC	1.62959969831693
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/910	157/9376	1.31252187303143	PPP2R2B/TGFB1/YWHAZ/DLG1/PPP2R2D/FBXW11/PPP1CA/TGFBR2/GSK3B/CCND3/BTRC/BMPR2/YWHAB/ACTG1/RASSF1/PPP2R2A/LLGL2/PRKCI/SMAD3/ACTB	1.29465943156346
Genetic Information Processing	Translation	hsa03010	Ribosome	27/910	222/9376	1.25310365310365	RPS21/RPL37/RPS26/RPL39/RPL37A/RPS27/RPL34/RPS29/RPS28/MRPL1/RPL27A/RPL6/UBA52/RPL38/MRPL54/RPS4X/RPL35A/RPS27A/RPS8/RPL36/RPS24/RPS10-NUDT3/RPS7/RPL30/RPL21/RPL7/MRPL10	1.2512285602916
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/910	105/9376	1.37377289377289	PRKCB/PRKCQ/CARD11/TRAF3/BCL2/RELB/NFKB1/MALT1/TNFAIP3/ERC1/ATM/TAB2/CSNK2A1/EDARADD	1.26271797912708
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/910	70/9376	1.47189952904239	FYN/PRF1/EIF4G3/SNTB1/ITGAL/CASP8/ABL1/ACTG1/ACTB/RAC1	1.29922462108425
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/910	187/9376	1.26725039666216	STAT1/NEK7/MAPK8/JAK1/TRAF3/CYBA/BCL2/MAPK1/NFKB1/NLRP1/TNFAIP3/ERBIN/PLCB1/ATG5/CASP8/ITPR1/PKN2/ANTXR2/MCU/TAB2/GBP4/TP53BP1/ITPR2	1.2102420494482
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/910	21/9376	1.96253270538985	CHST11/CSGALNACT1/CSGALNACT2/UST	1.44767291406492
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/910	14/9376	2.20784929356358	B4GALT1/FUT8/ST3GAL1	1.48272172648273
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/910	63/9376	1.47189952904239	CCNH/POLR2L/POLR2B/CUL4A/POLR2G/MNAT1/RAD23B/RBX1/ERCC1	1.23208939495125
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/910	38/9376	1.62683632157316	PRKCB/PIK3R1/MAPK1/ATP1B3/PIK3CD/NR3C2	1.26936412255426
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/910	30/9376	1.71721611721612	OGDH/SUCLG2/IDH2/DLST/SUCLA2	1.2899265499724
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/910	109/9376	1.32335920959774	MAP2K4/STAT1/MAPK8/JAK1/TRAF3/MAP3K8/PIK3R1/MAPK1/NFKB1/CASP8/MAP2K1/PIK3CD/TAB2/RAC1	1.11325871685353
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/910	110/9376	1.31132867132867	PRKCB/PIK3R1/CAMK2D/BCL2/MAPK1/NFKB1/CREBBP/ELOB/MAP2K1/PIK3CD/CUL2/IFNGR1/RPS6KB1/RBX1	1.0768036404315
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/910	110/9376	1.31132867132867	BRAF/STK10/PDE3B/RPS6KA3/MAPK8/PRKACB/PIK3R1/MAPK1/CDC27/SPDYE2/RAF1/MAP2K1/PIK3CD/SPDYE18	1.0768036404315
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	29/910	250/9376	1.19518241758242	CTSW/LITAF/OSBPL3/NPC1/AP3B1/RPTOR/MCOLN2/GNPTAB/RAB7A/ARSG/WDR7/ARL8B/GGA2/AP2B1/DMXL1/CTSS/HGSNAT/IGF2R/VPS13C/SLC15A4/SUMF1/AP1G1/VPS26A/CTSC/AP3M2/MANBA/ATP6V1H/ATP6V1G1/VPS13A	1.02550472897173
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	9/910	66/9376	1.404995004995	STAT4/TGFB1/STAT1/IL21R/IL12RB2/NFKB1/RORA/IFNGR1/SMAD3	1.08246533275668
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/910	75/9376	1.37377289377289	PIK3R1/MAP3K5/BCL2/REV3L/MAPK1/GSTP1/CASP8/PIK3CD/ATM/ERCC1	1.06546899100586
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/910	32/9376	1.60989010989011	RPTOR/ATG7/ATG5/ATG13/ATG2A	1.13299336708601
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/910	149/9376	1.24469356147208	GNG2/MT-ND3/PRKCB/GNAQ/MAPK8/GNB1/PRKACB/NDUFB1/MAPK1/NDUFB2/NDUFA4/PLCB1/ITPR1/NDUFS6/NDUFAB1/NDUFV1/ITPR2/NDUFA1	0.987080604240112
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/910	168/9376	1.22658294086866	STAT4/STAT5B/PIAS1/STAT1/SOS1/IL21R/JAK1/PIK3R1/BCL2/IL12RB2/CREBBP/CCND3/SOS2/PTPN2/IL2RB/RAF1/PIK3CD/IFNGR1/GRB2/JAK2	0.971552776288155
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/910	33/9376	1.56110556110556	VTI1A/STX8/VAMP5/STX5/VTI1B	1.05858459783399
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	40/910	362/9376	1.1384858235687	GNG2/PIK3R5/PPP2R5C/PPP2R2B/ITGA4/SOS1/CDK6/GNB1/JAK1/YWHAZ/PIK3R1/RPTOR/BCL2/PPP2R2D/MAPK1/GSK3B/NFKB1/ITGB1/PPP2R5A/CCND3/PDGFD/PIK3AP1/PPP2R3A/SOS2/PPP2R5E/CREB1/YWHAB/IL2RB/PKN2/RAF1/MAP2K1/PIK3CD/C8orf44-SGK3/GRB2/RPS6KB1/PPP2R2A/PPP2R3C/EFNA5/JAK2/RAC1	0.880984015694704
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/910	97/9376	1.27463464370681	GNG2/PRKCB/GNAQ/RPS6KA5/GNB1/PRKACB/CAMK2D/MAPK1/PLCB1/ITPR1/CREB1/CALM1	0.891369566960489
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/910	62/9376	1.32945763913506	ATXN1/MAML2/CREBBP/KAT2B/CIR1/PSEN1/NCOR2/NUMB	0.853285787958175
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/910	44/9376	1.404995004995	RAB11A/ARHGDIB/PRKACB/DCTN4/CREB1/DCTN5	0.882786823712464
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/910	27/9376	1.52641432641433	ELOVL5/HACD4/SCP2/HACD3	0.898036946690978
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/910	91/9376	1.24545344765125	GNG2/PDE7A/PRKCB/PDE4D/PDE3B/GRK5/GNB1/PRKACB/PDE4A/OPRM1/PDE4B	0.771375926429809
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/910	36/9376	1.43101343101343	GALNT11/B4GALT5/GALNT2/ST3GAL1/GALNT10	0.849446083267598
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/910	101/9376	1.22415406375802	PRKCB/GNAQ/PRKACB/CAMK2D/MAPK1/GSK3B/CREBBP/PLCB1/CREB1/CALM1/RAF1/MAP2K1	0.742536055720471
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/910	168/9376	1.16525379382522	STAT4/H2AZ2/H2AZ1/STAT5B/H2AC20/STAT1/MACROH2A1/H2AJ/MAPK8/JAK1/CAMK2D/BCL2/TNFAIP3/CASP8/VPS4B/GLUD1/IFNGR1/HMGB1/JAK2	0.708582833145033
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/910	73/9376	1.27026945657083	BRAF/CDK6/RB1/PIK3R1/MAPK1/PDGFD/RAF1/MAP2K1/PIK3CD	0.76000087147984
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/910	112/9376	1.19591836734694	PIK3R5/TGFB1/STAT1/MAPK8/JAK1/BCL2/MAPK1/NFKB1/ITGB1/CASP8/IFNGR1/TAB2/JAK2	0.683836209888846
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/910	93/9376	1.21866950254047	PRKCB/GNAQ/PRKACB/ATP2B1/ATP2B4/ATP1B3/PLCB1/ITPR1/CALM1/ITPR2/CD38	0.694788654891711
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/910	75/9376	1.2363956043956	TG/PRKCB/GNAQ/PRKACB/ATP1B3/PLCB1/ITPR1/CREB1/ITPR2	0.673864237588735
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/910	38/9376	1.3556969346443	CD8A/CD3D/CD8B/CD3E/ICOS	0.72029796583398
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/910	104/9376	1.18884192730347	GPCPD1/PLAAT2/SGMS1/SELENOI/AGPAT4/TAFAZZIN/CDS2/AGPAT3/PLPP1/LPIN2/GPD2/CHKA	0.634885757548147
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/910	29/9376	1.42114437286851	GNB1/CALM1/SLC24A1/RGS9	0.744665240184464
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/910	85/9376	1.21215255332902	ADSS2/ADK/RRM1/GUK1/NT5C2/HDDC2/ASMTL/CTPS1/APRT/GMPS	0.644159918302775
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/910	115/9376	1.16472049689441	GNG2/BRAF/PRKCB/GNAQ/GNB1/PRKACB/MAPK1/PLCB1/ITPR1/RAF1/MAP2K1/SLC18A2/ITPR2	0.582686322674822
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/910	12/9376	1.71721611721612	NPC1/NCAM1	0.815036696914798
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/910	116/9376	1.15467980295566	GNG2/SLC38A1/PRKCB/PPP3CC/GNAQ/PPP3CA/GNB1/PRKACB/MAPK1/PLCB1/ITPR1/PPP3CB/ITPR2	0.549571640444975
NA	NA	hsa04519	Cadherin signaling	42/910	404/9376	1.07113480578827	ARPC2/MYO1F/MAPK8/YWHAZ/VAV3/EVL/KRT6A/TAOK3/CYFIP2/MAPK1/PPP1CA/GSK3B/NFKB1/MYO1D/CREBBP/ACTR3/ADAM10/ARPC3/RRAS2/ERBIN/KRT24/ARPC5/PSEN1/YWHAB/SHOC2/ACTR2/RAF1/MAP2K1/TMC8/TAOK1/VAV1/RERE/ACTG1/ARPC5L/KRT14/KRT10/KRT17/ARPC4/ARHGAP35/KRT5/ACTB/RAC1	0.479176380290715
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/910	217/9376	1.09205448928951	PRKCB/STAT5B/ESR2/SOS1/RPS6KA3/RB1/PRKACB/PIK3R1/BCL2/MAPK1/NFKB1/CCND3/KPNA1/SOS2/KPNA6/CREB1/RAF1/MAP2K1/PIK3CD/KPNA3/GRB2/RPS6KB1/JAK2	0.449798510169212
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/910	148/9376	1.11386991386991	BRAF/NCOA1/ESR2/SOS1/CDK6/RB1/PIK3R1/MAPK1/GSK3B/SOS2/NCOA3/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1	0.457776252141944
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/910	41/9376	1.25649959796301	BABAM2/RAD51B/SEM1/ATM/TOPBP1	0.53962077115722
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/910	51/9376	1.21215255332902	PLAAT2/PAFAH1B1/SELENOI/AGPS/PLPP1/PEDS1	0.498053656803287
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/910	51/9376	1.21215255332902	PRKACB/SEC61G/ACTG1/ATP6V1H/ATP6V1G1/ACTB	0.498053656803287
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/910	32/9376	1.28791208791209	BIRC6/MAPK8/BCL2/CASP8	0.534854526444208
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/910	150/9376	1.09901831501832	BRAF/TGFB1/SOS1/RB1/PIK3R1/BCL2/MAPK1/TGFBR2/GSK3B/SOS2/RAF1/MAP2K1/PIK3CD/GRB2/RPS6KB1/SMAD3	0.400794394074485
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/910	23/9376	1.3439082656474	MVD/PDSS2/NUS1	0.541375087717859
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/910	23/9376	1.3439082656474	PREP/PRCP/LNPEP	0.541375087717859
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/910	62/9376	1.16327543424318	FOXO1/PRKACB/PIK3R1/RPTOR/ATG5/PIK3CD/RPS6KB1	0.422878667886309
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/910	142/9376	1.08837641232007	MAP2K4/MAPK8/CYBA/PIK3R1/MAP3K5/BCL2/GSTP1/NFKB1/CALM1/BMPR2/PIK3CD/ACTG1/NFE2L2/ACTB/RAC1	0.347898700534546
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/910	93/9376	1.10788136594588	CDK6/RB1/TRAF3/PIK3R1/BCL2/NFKB1/ITGB1/PIK3CD/ZBTB17/MAX	0.342776419494289
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/910	34/9376	1.21215255332902	POLR1F/POLR2L/POLR2B/POLR2G	0.406288932734877
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/910	26/9376	1.18884192730347	BTD/CUBN/LMBRD1	0.31611601242607
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/910	87/9376	1.06585827965138	COX7C/ATP1B3/COX6C/COX7A2/TPM3/UQCRB/UQCRFS1/COX7B/COX4I1	0.202326481468768
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/910	128/9376	1.04642857142857	ADSS2/PDE7A/PDE4D/PDE3B/ADK/PDE4A/RRM1/GUK1/NT5C2/HDDC2/APRT/PDE4B/GMPS	0.173393813209823
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/910	47/9376	1.09609539396773	MAPK8/PIK3R1/MAPK1/PRKCE/PIK3CD	0.21652156443444
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/910	37/9376	1.11386991386991	PRKCB/GNAQ/HBB/PLCB1	0.227523819005147
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/910	37/9376	1.11386991386991	BRAF/MAPK1/TPM3/MAP2K1	0.227523819005147
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/910	17/9376	1.21215255332902	CA5B/GLUD1	0.287028619600088
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/910	254/9376	1.01410400622999	NFATC2/PRKCB/CAMK1D/PPP3CC/CAMK4/GNAQ/STIM1/PPP3CA/STIM2/PRKACB/ATP2B1/MCOLN2/ATP2B4/CAMK2D/ITPKB/PDGFD/PLCB1/NFATC3/ITPR1/CALM1/PPP3CB/PHKB/MCU/ITPR2/CD38	0.0747104784692892
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/910	48/9376	1.07326007326007	PRKCB/PIK3R1/ATP1B3/PLCB1/PIK3CD	0.166824910640984
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/910	100/9376	1.03032967032967	CD3G/ITGA4/CD8A/CD3D/CD44/CD8B/CD3E/CD5/CD38/CD7	0.0999665080744888
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/910	59/9376	1.04779288508102	DPYD/RRM1/NT5C2/HDDC2/ASMTL/CTPS1	0.120730891746315
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/910	28/9376	1.10392464678179	ELOVL5/HACD4/HACD3	0.180553296967352
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/910	28/9376	1.10392464678179	PTS/GCH1/GPHN	0.180553296967352
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/910	49/9376	1.05135680645885	PRKACB/NFKB1/CREB1/SLC18A2/RGS9	0.118165926346669
NA	NA	hsa04518	Integrin signaling	15/910	154/9376	1.00356786071072	TGFB1/ITGA4/PIK3R1/ITGAL/GSK3B/ITGB1/PXN/CCND3/PDGFD/FLNA/PIK3CD/ACTG1/TLN1/ACTB/RAC1	0.014636016652567
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/910	144/9376	1.0017094017094	JARID2/KAT6A/JAK1/PIK3R1/PCGF5/MAPK1/GSK3B/BMPR2/RAF1/MAP2K1/PIK3CD/GRB2/SMAD3/JAK2	0.00677711233407506
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/910	71/9376	1.01581798483207	MAP2K4/MAPK8/NFKB1/ADAM10/ATP6V1H/ATP6V1G1/RAC1	0.0438620921201684
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/910	71/9376	1.01581798483207	PIK3R1/MAPK1/SLC7A5/IDH2/RAF1/MAP2K1/PIK3CD	0.0438620921201684
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	15/910	155/9376	0.997093229351294	RAP1B/BRAF/GNAQ/CDK6/RB1/PRKACB/RAP1A/CAMK2D/MAPK1/GSK3B/PLCB1/ITPR1/CREB1/MAP2K1/ITPR2	-0.0119634050367831
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/910	103/9376	1.00032006828123	PRKCB/TGFB1/GNAQ/PRKACB/PIK3R1/RAB7A/NFKB1/PLCB1/PIK3CD/SERPINB9	0.00107082455756823
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/910	72/9376	1.0017094017094	RNF125/MAPK8/TRAF3/NFKB1/ATG5/CASP8/ZNFX1	0.0047735638237324
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/910	19/9376	1.08455754771544	OGDH/DLST	0.120956181324397
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/910	94/9376	0.986485854570961	MAPK8/TRAF3/USP25/MAPK1/GSK3B/NFKB1/TNFAIP3/CASP8/TAB2	-0.0431716786003015
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/910	180/9376	0.973089133089133	STAT1/JAK1/TRAF3/PIK3R1/BCL2/PDIA3/PPP1CA/NFKB1/CASP8/SRSF4/POU2F1/SP100/PIK3CD/IFNGR1/TAB2/CD74/JAK2	-0.119517544506803
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/910	75/9376	0.961641025641026	COP1/CDK6/BCL2/CCND3/CASP8/PPM1D/ATM	-0.109345269245525
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/910	32/9376	0.965934065934066	SUCLG2/PCCA/SUCLA2	-0.0632843141975971
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/910	65/9376	0.951073541842773	GNAQ/PRKACB/PLCB1/ITPR1/CREB1/ITPR2	-0.129768562890306
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/910	55/9376	0.936663336663337	SGMS1/B4GALT5/CERS5/PLPP1/SPTLC2	-0.154444509394765
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/910	44/9376	0.936663336663337	POLB/PARP4/ADPRS/HMGB1	-0.13805792951004
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/910	33/9376	0.936663336663337	OGDH/IDH2/DLST	-0.119491270331172
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/910	10/9376	1.03032967032967	BPNT2	0.0314599345891852
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/910	57/9376	0.903797956429535	ELOVL5/HACD4/CPT1A/SCP2/HACD3	-0.238838465305606
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/910	23/9376	0.895938843764931	B4GALT1/POMT1	-0.163811467219991
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/910	23/9376	0.895938843764931	ATP1B3/GLUD1	-0.163811467219991
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/910	233/9376	0.92862330802245	ITGA4/SYNE2/SNTB1/CAPZB/CAPZA1/DCN/SYNE1/DIAPH1/ITGB1/MYH9/ATP1B3/DIAPH2/TMOD3/TPM3/LBR/PDLIM5/ACTG1/ANK3/TLN1/CAPZA2/ACTB	-0.361707254522151
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/910	70/9376	0.883139717425432	PRKCQ/MAPK8/NFKB1/CPT1A/TNFRSF1B/JAK2	-0.321737461056259
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/910	59/9376	0.873160737567517	PLAAT2/PDE3B/PRKACB/PIK3R1/PIK3CD	-0.3204120704569
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/910	24/9376	0.858608058608059	EXT1/HS2ST1	-0.227376319156728
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/910	82/9376	0.879549718574109	CD8A/KLRD1/PDIA3/CD8B/CREB1/CTSS/CD74	-0.359153922095783
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/910	160/9376	0.901538461538462	ITGA4/CD8A/GLG1/CD6/ITGAL/CD99/ITGB1/CD8B/SELPLG/NCAM1/CD226/ALCAM/CD58/ICOS	-0.411834360230721
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/910	83/9376	0.868952734012975	PEX14/IDH2/AGPS/FAR1/SCP2/HACL1/ABCD3	-0.393148157507982
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/910	50/9376	0.824263736263736	TGFB1/ITGAL/KLRC4-KLRK1/HBB	-0.408475382092088
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/910	86/9376	0.838640429338104	PRKCB/GNAQ/PRKACB/CAMK2D/ATP1B3/PLCB1/CREB1	-0.49283699466901
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/910	52/9376	0.792561284868977	NPC1/LIPC/VAPA/STARD3NL	-0.491764931654158
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/910	65/9376	0.792561284868977	AGPAT4/LIPC/AGPAT3/PLPP1/LPIN2	-0.550193595944734
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/910	78/9376	0.792561284868977	MAPK8/MAPK1/NFKB1/ITGB1/CALM1/CFL1	-0.603128077176425
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/910	15/9376	0.686886446886447	ST3GAL1	-0.397881343429551
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/910	79/9376	0.782528863541522	NAPA/AP2B1/DNM2/SLC18A2/ATP6V1H/ATP6V1G1	-0.636371844352681
NA	NA	hsa04382	Cornified envelope formation	18/910	217/9376	0.854651339443966	PPP2R5C/S100A6/PPP2R2B/S100A4/KRT6A/PPP2R2D/PPP2R5A/PPP2R3A/KRT24/PPP2R5E/SPRR3/PPP2R2A/SPTLC2/PPP2R3C/KRT14/KRT10/KRT17/KRT5	-0.710205569307774
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/910	30/9376	0.686886446886447	NFKB1/ABCC4	-0.563140559201435
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/910	16/9376	0.643956043956044	ST3GAL1	-0.467296886192143
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/910	56/9376	0.735949764521193	RAB1A/NFKB1/CASP8/HBS1L	-0.649740321129236
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/910	105/9376	0.785013082155939	TGFB1/ITGA4/SNTB1/PRKACB/ITGB1/TPM3/ACTG1/ACTB	-0.726290886689491
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/910	323/9376	0.861266287891675	PRKCB/ZEB2/ZEB1/SOS1/CDK6/RPS6KA5/PIK3R1/RPTOR/BCL2/MAPK1/PRKCE/NFKB1/CREBBP/HDAC4/CD44/SOS2/SLC7A1/PDCD4/BMPR2/RAF1/MAP2K1/PIK3CD/ATM/ABL1/RASSF1/GRB2/EFNA5	-0.831867601240202
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/910	17/9376	0.606076276664512	SCP2	-0.532953201658421
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/910	17/9376	0.606076276664512	MARS1	-0.532953201658421
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/910	17/9376	0.606076276664512	MYH9	-0.532953201658421
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/910	45/9376	0.686886446886447	GZMB/PRF1/KLRD1	-0.690257653769345
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/910	32/9376	0.643956043956044	GALM/B4GALT1	-0.661423154839402
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/910	144/9376	0.787057387057387	MAP2K4/MAPK8/FOXO1/TRAF3/MAP3K5/GSK3B/NFKB1/CASP8/CPT1A/TAB2/LPIN2	-0.844234565044774
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/910	18/9376	0.572405372405372	MANBA	-0.595311365987334
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/910	18/9376	0.572405372405372	LMBRD1	-0.595311365987334
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/910	61/9376	0.675626013330931	ATP2B1/ATP2B4/MT2A/ATP1B3	-0.833271846419579
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/910	19/9376	0.542278773857721	HGSNAT	-0.654751859781996
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/910	99/9376	0.728515928515929	TGFB1/ITGA4/SNTB1/ITGB1/TPM3/ACTG1/ACTB	-0.890277453777477
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/910	20/9376	0.515164835164835	LBR	-0.711592242618986
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/910	20/9376	0.515164835164835	GMDS	-0.711592242618986
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/910	89/9376	0.694604272132362	GNG2/SLC38A1/PRKCB/GNB1/PRKACB/GPHN	-0.949046387346015
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/910	50/9376	0.618197802197802	TGFB1/ITGA4/ICOS	-0.88744801622108
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/910	36/9376	0.572405372405372	PRIM2/RNASEH2B	-0.842708267309668
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/910	21/9376	0.490633176347462	DPYD	-0.766100257992169
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/910	37/9376	0.556934956934957	ADSS2/GLUD1	-0.885289601439433
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/910	38/9376	0.542278773857721	NT5C2/CD38	-0.926900504326848
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/910	155/9376	0.731201701524282	CYBA/RAB7A/ITGB1/CTSS/STX12/SEC61G/ACTG1/ATP6V1H/ATP6V1G1/ACTB/RAC1	-1.10629399649903
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/910	39/9376	0.528374189912651	GZMB/PRF1	-0.967594498876514
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/910	23/9376	0.447969421882465	GLUD1	-0.868998022157841
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/910	54/9376	0.572405372405372	REV3L/WDR48/ERCC1	-1.03309859971193
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/910	54/9376	0.572405372405372	GZMB/TG/PRF1	-1.03309859971193
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/910	42/9376	0.490633176347462	ATG7/ATG5	-1.08464746124219
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/910	99/9376	0.624442224442224	ITGAL/KRT24/SELPLG/KRT14/KRT10/KRT17	-1.23156625116964
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/910	86/9376	0.599028878098645	ITGA4/SNTB1/ITGB1/ACTG1/ACTB	-1.22467729590699
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/910	26/9376	0.396280642434489	PLAAT2	-1.01060902450626
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/910	59/9376	0.52389644254051	GSTP1/RRM1/IDH2	-1.20269799486333
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/910	44/9376	0.468331668331668	GZMB/PRF1	-1.15890268273254
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/910	27/9376	0.381603581603582	OXCT1	-1.05495387103933
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/910	45/9376	0.457924297924298	ABCC4/ABCD3	-1.19500385262611
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/910	116/9376	0.621750663129974	OGDH/SUCLG2/IDH2/PCCA/GLUD1/DLST/SUCLA2	-1.34390595661973
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/910	28/9376	0.367974882260596	B4GALT1	-1.09804769424556
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/910	28/9376	0.367974882260596	ATP6V1G1	-1.09804769424556
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/910	143/9376	0.648459233074618	H3-3A/H3-3B/H2AZ2/H2AZ1/H4C3/H2AC20/MACROH2A1/H2AJ/H3C4	-1.38879933250193
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/910	243/9376	0.72080676525121	U2AF1/HNRNPC/HNRNPA1/SRSF4/DHX8/U2SURP/TXNL4A/AQR/CCDC12/SRSF10/SF3B6/SNIP1/HNRNPA3/SNRPB2/THOC2/NCBP1/MAGOH	-1.44566777627944
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/910	29/9376	0.355286093217128	RASSF1	-1.13997970096261
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/910	30/9376	0.343443223443223	PLAAT2	-1.18082959559271
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/910	48/9376	0.429304029304029	PCCA/OXCT1	-1.29956605389327
NA	NA	hsa03272	Virion - Hepatitis viruses	2/910	48/9376	0.429304029304029	VPS4B/PDCD6IP	-1.29956605389327
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/910	31/9376	0.332364409783765	DPYD	-1.22066889001759
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/910	31/9376	0.332364409783765	PCCA	-1.22066889001759
NA	NA	hsa04981	Folate transport and metabolism	1/910	31/9376	0.332364409783765	ABCC4	-1.22066889001759
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/910	82/9376	0.502599839185205	DPYD/GSTP1/RRM1/GMPS	-1.48312827909513
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/910	83/9376	0.496544419435986	POLR2L/NFKB1/CASP8/SAMHD1	-1.51039117371171
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/910	35/9376	0.294379905808477	GMDS	-1.37112003949917
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/910	37/9376	0.278467478467478	GMDS	-1.44169631166172
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/910	89/9376	0.463069514754908	ITGA4/ITGB1/CD44/CD47	-1.66856275572608
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/910	39/9376	0.264187094956326	AHCYL2	-1.50960465668905
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/910	76/9376	0.406709080393291	DBI/CPT1A/SCP2	-1.70255137445688
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/910	95/9376	0.433823019086177	TGFB1/ITGAL/ATP6V1H/ATP6V1G1	-1.81837657016188
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/910	42/9376	0.245316588173731	DLST	-1.60702544545252
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/910	43/9376	0.239611551239458	CPT1A	-1.63842402624377
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/910	43/9376	0.239611551239458	PLPP1	-1.63842402624377
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/910	100/9376	0.412131868131868	CX3CR1/XCL2/IL2RB/TNFRSF1B	-1.93761170867857
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/910	46/9376	0.223984710941233	EPRS1	-1.7297190722837
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/910	47/9376	0.219219078793547	ACYP2	-1.75925088144129
NA	NA	hsa04081	Hormone signaling	12/910	219/9376	0.564564202920367	GNG2/STAT5B/ESR2/GNAQ/GNB1/PRKACB/PIK3R1/GNA13/PLCB1/OPRM1/PIK3CD/JAK2	-2.13765090028837
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/910	90/9376	0.343443223443223	PRKACB/ATP1B3/ABCC4	-2.05185376519145
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/910	52/9376	0.198140321217244	PRKACB	-1.90092996808123
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/910	54/9376	0.190801790801791	AHCYL2	-1.95507960779294
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/910	183/9376	0.450417342220621	XRN1/XRN2/NOP58/MDN1/RIOK1/CSNK2A1/XPO1/PWP2	-2.46148467985978
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/910	154/9376	0.401427144284287	ADSS2/EPRS1/PTS/GCH1/CTPS1/GPHN	-2.45545524176788
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/910	63/9376	0.163544392115821	PLAAT2	-2.1839142029087
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/910	63/9376	0.163544392115821	GSK3B	-2.1839142029087
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/910	86/9376	0.239611551239458	PRKACB/PLCB1	-2.32243774776397
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/910	67/9376	0.153780547810399	GALM	-2.27895680024403
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/910	70/9376	0.147189952904239	GSTP1	-2.34794006373189
NA	NA	hsa04082	Neuroactive ligand signaling	8/910	199/9376	0.414202882544591	GNG2/PRKCB/GNAQ/GNB1/PRKACB/PLCB1/OPRM1/SLC18A2	-2.73836039495814
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/910	73/9376	0.141141050730092	GSTP1	-2.41512140589344
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/910	75/9376	0.137377289377289	IDH2	-2.4589737897483
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/910	103/9376	0.200064013656247	ATP1B3/PRCP	-2.67627612257879
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/910	79/9376	0.13042147725692	GSTP1	-2.54459188165943
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/910	88/9376	0.117082917082917	A2M	-2.72814440664118
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/910	298/9376	0.414897853824028	TGFB1/RELL1/CX3CR1/IL21R/IL12RB2/TGFBR2/BMPR2/XCL2/IL2RB/TNFRSF1B/IFNGR1/TNFSF8	-3.3652081826266
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/910	370/9376	0.167080487080487	P2RY8/GZMA/NR3C1/UTS2/OPRM1/S1PR5	-5.3592637329571
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/910	449/9376	0.114736043466556	NCALD/GNB1/PRKACB/CAMK2D/CALM1	-6.30246420418406