ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 94/1707 489/18639 0.192229038854806 2.09897894271513 2.62386149200565e-12 1.71572630443424e-09 GO:0060589 nucleoside-triphosphatase regulator activity 94/1707 490/18639 0.191836734693878 2.09469531221979 2.96325786603496e-12 1.71572630443424e-09 GO:0003712 transcription coregulator activity 94/1707 495/18639 0.18989898989899 2.07353677371252 5.40464361798236e-12 2.08619243654119e-09 GO:0004674 protein serine/threonine kinase activity 85/1707 433/18639 0.196304849884527 2.14348336086567 9.52816704886789e-12 2.22403093421794e-09 GO:0106310 protein serine kinase activity 75/1707 361/18639 0.207756232686981 2.26852280085099 9.60289695258179e-12 2.22403093421794e-09 GO:0045296 cadherin binding 67/1707 334/18639 0.20059880239521 2.19036969996738 5.91951726486491e-10 9.28702023387012e-08 GO:0019902 phosphatase binding 46/1707 190/18639 0.242105263157895 2.64358523725835 6.04401090685287e-10 9.28702023387012e-08 GO:0019787 ubiquitin-like protein transferase activity 86/1707 479/18639 0.179540709812109 1.96043309325594 8.30809526916165e-10 9.28702023387012e-08 GO:0140857 histone H3T45 kinase activity 54/1707 246/18639 0.219512195121951 2.3968879934845 9.76086435249742e-10 9.28702023387012e-08 GO:0035403 histone H3T6 kinase activity 54/1707 247/18639 0.218623481781377 2.38718399351088 1.13997910169313e-09 9.28702023387012e-08 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 53/1707 243/18639 0.218106995884774 2.38154440321986 1.77220829779494e-09 9.28702023387012e-08 GO:0005096 GTPase activator activity 57/1707 271/18639 0.210332103321033 2.2966491352084 1.83562882282339e-09 9.28702023387012e-08 GO:0004842 ubiquitin-protein transferase activity 81/1707 449/18639 0.180400890868597 1.96982554475675 2.0559528348452e-09 9.28702023387012e-08 GO:0004676 3-phosphoinositide-dependent protein kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0004711 ribosomal protein S6 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0035175 histone H3S10 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0035979 histone H2AXS139 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0044022 histone H3S28 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0044023 histone H4S1 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0044024 histone H2AS1 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0044025 histone H2BS14 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0072354 histone H3T3 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0072371 histone H2AS121 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0072518 Rho-dependent protein serine/threonine kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0140823 histone H2BS36 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0140855 histone H3S57 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0140995 histone H2A kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0140997 histone H4 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0140998 histone H2B kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:1990244 histone H2AT120 kinase activity 53/1707 245/18639 0.216326530612245 2.36210322441806 2.40596379115806e-09 9.28702023387012e-08 GO:0004677 DNA-dependent protein kinase activity 53/1707 246/18639 0.215447154471545 2.35250117879035 2.79862441221059e-09 1.04542163527092e-07 GO:0035402 histone H3T11 kinase activity 53/1707 247/18639 0.214574898785425 2.34297688251994 3.25175947126949e-09 1.17673045866565e-07 GO:0004679 AMP-activated protein kinase activity 53/1707 248/18639 0.213709677419355 2.33352939509042 3.77411309513502e-09 1.32437059520192e-07 GO:0016755 aminoacyltransferase activity 86/1707 496/18639 0.173387096774194 1.89324082997902 4.73502978205742e-09 1.56665972261576e-07 GO:0004812 aminoacyl-tRNA ligase activity 18/1707 41/18639 0.439024390243902 4.79377598696901 4.8704447335205e-09 1.56665972261576e-07 GO:0016875 ligase activity, forming carbon-oxygen bonds 18/1707 41/18639 0.439024390243902 4.79377598696901 4.8704447335205e-09 1.56665972261576e-07 GO:0140996 histone H3 kinase activity 66/1707 357/18639 0.184873949579832 2.01866757247715 2.41407070809316e-08 7.55538886478887e-07 GO:0035173 histone kinase activity 66/1707 360/18639 0.183333333333333 2.0018453427065 3.37422865924499e-08 1.01785792171812e-06 GO:0051020 GTPase binding 60/1707 315/18639 0.19047619047619 2.07983931709767 3.42801890734081e-08 1.01785792171812e-06 GO:0141003 histone H2AX kinase activity 65/1707 354/18639 0.18361581920904 2.0049298501683 4.02988482552216e-08 1.16665165698867e-06 GO:0140030 modification-dependent protein binding 39/1707 173/18639 0.225433526011561 2.46154393165172 9.55360339575204e-08 2.69831042250753e-06 GO:0035091 phosphatidylinositol binding 54/1707 284/18639 0.190140845070423 2.07617762815911 1.74224508862808e-07 4.80361860150315e-06 GO:0031491 nucleosome binding 22/1707 74/18639 0.297297297297297 3.24623569087541 4.2830925128356e-07 1.15344677438689e-05 GO:0019208 phosphatase regulator activity 29/1707 117/18639 0.247863247863248 2.70645757288991 5.11543176783226e-07 1.34628863344313e-05 GO:0051219 phosphoprotein binding 25/1707 93/18639 0.268817204301075 2.93525710074267 6.02745700255529e-07 1.55106560199089e-05 GO:0045309 protein phosphorylated amino acid binding 19/1707 59/18639 0.322033898305085 3.51633850644902 6.64254421405085e-07 1.67218830431976e-05 GO:0031267 small GTPase binding 52/1707 283/18639 0.183745583038869 2.00634676172319 8.7661249741173e-07 2.15982398298465e-05 GO:0042393 histone binding 47/1707 247/18639 0.190283400809717 2.07773421657429 1.05003572229945e-06 2.53321118004743e-05 GO:0019903 protein phosphatase binding 32/1707 144/18639 0.222222222222222 2.42647920328061 1.83429643267471e-06 4.33492912048432e-05 GO:0061659 ubiquitin-like protein ligase activity 62/1707 372/18639 0.166666666666667 1.81985940246046 2.59805730285942e-06 6.01710071342241e-05 GO:0003713 transcription coactivator activity 47/1707 256/18639 0.18359375 2.00468887302285 2.96295187193466e-06 6.72764366215752e-05 GO:0070063 RNA polymerase binding 18/1707 59/18639 0.305084745762712 3.33126805874118 3.13803531314313e-06 6.98816325503797e-05 GO:0031490 chromatin DNA binding 29/1707 128/18639 0.2265625 2.47387137521968 3.65467376941181e-06 7.98511740562052e-05 GO:0005085 guanyl-nucleotide exchange factor activity 43/1707 230/18639 0.18695652173913 2.04140750362956 4.77038944506635e-06 0.00010229835143309 GO:0140297 DNA-binding transcription factor binding 75/1707 488/18639 0.153688524590164 1.67814903915411 5.51065706073474e-06 0.000116024379569651 GO:0003714 transcription corepressor activity 39/1707 204/18639 0.191176470588235 2.08748578517523 7.51664302180809e-06 0.000155433439629532 GO:0061630 ubiquitin protein ligase activity 58/1707 353/18639 0.164305949008499 1.79408235709983 8.45377109582279e-06 0.000171745033841453 GO:0019888 protein phosphatase regulator activity 25/1707 107/18639 0.233644859813084 2.55120476980438 9.46515424223526e-06 0.000188976700215663 GO:0031492 nucleosomal DNA binding 14/1707 42/18639 0.333333333333333 3.63971880492091 1.24584249791478e-05 0.000244522985183952 GO:0005543 phospholipid binding 74/1707 497/18639 0.148893360160966 1.62578988871719 1.95014510795741e-05 0.00037637800583578 GO:0032182 ubiquitin-like protein binding 26/1707 120/18639 0.216666666666667 2.36581722319859 2.63576802052464e-05 0.000500363830781563 GO:0043130 ubiquitin binding 23/1707 100/18639 0.23 2.51140597539543 2.78070287079098e-05 0.00051936353618967 GO:0017124 SH3 domain binding 25/1707 115/18639 0.217391304347826 2.3737296553832 3.52308594894487e-05 0.000647576750615581 GO:0016874 ligase activity 32/1707 167/18639 0.191616766467066 2.09229344474496 4.55797140925893e-05 0.000824707951862788 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 55/1707 349/18639 0.157593123209169 1.72078396221189 4.73966868788338e-05 0.000844390206241377 GO:0000993 RNA polymerase II complex binding 12/1707 36/18639 0.333333333333333 3.63971880492091 5.19336801196089e-05 0.000911200023916774 GO:0043175 RNA polymerase core enzyme binding 13/1707 42/18639 0.30952380952381 3.37973889028371 6.14869104150398e-05 0.00106271406359128 GO:0019207 kinase regulator activity 47/1707 287/18639 0.163763066202091 1.78815453482177 6.35516578177042e-05 0.00108224734930737 GO:0001098 basal transcription machinery binding 16/1707 60/18639 0.266666666666667 2.91177504393673 6.94077299823635e-05 0.00114820216170824 GO:0001099 basal RNA polymerase II transcription machinery binding 16/1707 60/18639 0.266666666666667 2.91177504393673 6.94077299823635e-05 0.00114820216170824 GO:0031625 ubiquitin protein ligase binding 48/1707 302/18639 0.158940397350993 1.73549505930004 0.000113350158054361 0.00184872511305563 GO:0044389 ubiquitin-like protein ligase binding 50/1707 322/18639 0.15527950310559 1.69552118241657 0.000148913292431184 0.00236312185745788 GO:1901981 phosphatidylinositol phosphate binding 33/1707 185/18639 0.178378378378378 1.94774141452525 0.000148970548872561 0.00236312185745788 GO:0061980 regulatory RNA binding 15/1707 58/18639 0.258620689655172 2.82391976243864 0.000168840806618974 0.00264213046033475 GO:0061631 ubiquitin conjugating enzyme activity 11/1707 35/18639 0.314285714285714 3.43173487321115 0.000193317832620512 0.00298482733566071 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 12/1707 41/18639 0.292682926829268 3.19585065797934 0.000212820951167919 0.0032427192296375 GO:0001784 phosphotyrosine residue binding 13/1707 47/18639 0.276595744680851 3.02019219982799 0.000219647508187354 0.00330327031793449 GO:0019211 phosphatase activator activity 9/1707 25/18639 0.36 3.93089630931459 0.000233206813987275 0.00346222423842646 GO:0016922 nuclear receptor binding 26/1707 137/18639 0.18978102189781 2.0722486626557 0.000265491297746272 0.00389163193405295 GO:0035197 siRNA binding 6/1707 12/18639 0.5 5.45957820738137 0.000332447592873857 0.004704422774974 GO:0051010 microtubule plus-end binding 8/1707 21/18639 0.380952380952381 4.15967863419533 0.000333128383029247 0.004704422774974 GO:0072542 protein phosphatase activator activity 8/1707 21/18639 0.380952380952381 4.15967863419533 0.000333128383029247 0.004704422774974 GO:0003779 actin binding 62/1707 443/18639 0.139954853273138 1.52818893389456 0.000497858738485695 0.00694602914658355 GO:0000287 magnesium ion binding 37/1707 230/18639 0.160869565217391 1.75655994498357 0.000518192687904929 0.007122356595141 GO:0071889 14-3-3 protein binding 10/1707 33/18639 0.303030303030303 3.30883527720083 0.000522798195670972 0.007122356595141 GO:0035591 signaling adaptor activity 24/1707 129/18639 0.186046511627907 2.03147096088609 0.000606203930596283 0.00815330280474245 GO:0046875 ephrin receptor binding 9/1707 28/18639 0.321428571428571 3.50972884760231 0.000612553837661998 0.00815330280474245 GO:0070577 lysine-acetylated histone binding 8/1707 23/18639 0.347826086956522 3.79796744861313 0.000679695830178028 0.00887270747112363 GO:0030276 clathrin binding 12/1707 46/18639 0.260869565217391 2.84847558645985 0.000681926567297067 0.00887270747112363 GO:0031593 polyubiquitin modification-dependent protein binding 14/1707 59/18639 0.23728813559322 2.5909862679098 0.000712452448472644 0.00916688817034802 GO:0043539 protein serine/threonine kinase activator activity 16/1707 73/18639 0.219178082191781 2.39323976213978 0.000782921937043094 0.00996289673731761 GO:0140566 histone reader activity 10/1707 35/18639 0.285714285714286 3.1197589756465 0.000875307661834297 0.0109153403121529 GO:0061650 ubiquitin-like protein conjugating enzyme activity 11/1707 41/18639 0.268292682926829 2.92952976981439 0.000876620595017458 0.0109153403121529 GO:0140033 acetylation-dependent protein binding 8/1707 24/18639 0.333333333333333 3.63971880492091 0.000938351823592613 0.011518218931347 GO:0140463 chromatin-protein adaptor activity 13/1707 54/18639 0.240740740740741 2.62868580355399 0.000944931604903247 0.011518218931347 GO:0019887 protein kinase regulator activity 39/1707 255/18639 0.152941176470588 1.66998862814018 0.00101493762390201 0.012242685088318 GO:0035198 miRNA binding 11/1707 42/18639 0.261904761904762 2.85977906100929 0.00109068273382495 0.0130207278945288 GO:0140098 catalytic activity, acting on RNA 54/1707 387/18639 0.13953488372093 1.52360322066457 0.00118899290219066 0.0140495283748652 GO:0001222 transcription corepressor binding 12/1707 49/18639 0.244897959183673 2.67407912198271 0.00125020833618413 0.0146236490232446 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 6/1707 15/18639 0.4 4.3676625659051 0.00141480608813302 0.0162212420797825 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 6/1707 15/18639 0.4 4.3676625659051 0.00141480608813302 0.0162212420797825 GO:0016248 channel inhibitor activity 11/1707 44/18639 0.25 2.72978910369069 0.0016483809516537 0.0185322829321843 GO:0043014 alpha-tubulin binding 11/1707 44/18639 0.25 2.72978910369069 0.0016483809516537 0.0185322829321843 GO:0140101 catalytic activity, acting on a tRNA 24/1707 139/18639 0.172661870503597 1.88532197089429 0.00178151303078428 0.0198364624004635 GO:0009931 calcium-dependent protein serine/threonine kinase activity 7/1707 21/18639 0.333333333333333 3.63971880492091 0.00196014157638294 0.0216175613852518 GO:0019209 kinase activator activity 25/1707 148/18639 0.168918918918919 1.8444520970883 0.00198015105857186 0.0216322162813793 GO:0141110 transporter inhibitor activity 11/1707 45/18639 0.244444444444444 2.66912712360867 0.00200398684406495 0.0216880071535253 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/1707 16/18639 0.375 4.09468365553603 0.00208948836061719 0.0221984176293093 GO:0034450 ubiquitin-ubiquitin ligase activity 6/1707 16/18639 0.375 4.09468365553603 0.00208948836061719 0.0221984176293093 GO:0035064 methylated histone binding 15/1707 74/18639 0.202702702702703 2.21334251650596 0.00257244462176697 0.0270808261091469 GO:0050321 tau-protein kinase activity 7/1707 22/18639 0.318181818181818 3.47427704106087 0.00265008558911651 0.0276468388486209 GO:0051015 actin filament binding 32/1707 209/18639 0.15311004784689 1.671832561112 0.00268899886921609 0.0278023275942164 GO:0046966 nuclear thyroid hormone receptor binding 8/1707 28/18639 0.285714285714286 3.1197589756465 0.0028486908610086 0.0289367019039294 GO:0141052 histone H3 demethylase activity 8/1707 28/18639 0.285714285714286 3.1197589756465 0.0028486908610086 0.0289367019039294 GO:1990518 single-stranded 3'-5' DNA helicase activity 11/1707 47/18639 0.234042553191489 2.5555472460083 0.00290198488679682 0.0289397035120341 GO:0034452 dynactin binding 5/1707 12/18639 0.416666666666667 4.54964850615114 0.00292801493897754 0.0289397035120341 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 5/1707 12/18639 0.416666666666667 4.54964850615114 0.00292801493897754 0.0289397035120341 GO:0019003 GDP binding 15/1707 75/18639 0.2 2.18383128295255 0.0029489507896546 0.0289397035120341 GO:0003925 G protein activity 12/1707 54/18639 0.222222222222222 2.42647920328061 0.00303169962032083 0.0295017492464834 GO:0000149 SNARE binding 19/1707 106/18639 0.179245283018868 1.95720728189143 0.00332467894899236 0.0320831518577763 GO:0140034 methylation-dependent protein binding 15/1707 76/18639 0.197368421052632 2.15509666080844 0.00336967599447994 0.0322486347240311 GO:0043138 3'-5' DNA helicase activity 11/1707 48/18639 0.229166666666667 2.50230667838313 0.00345897217922194 0.0328318834716312 GO:0048487 beta-tubulin binding 10/1707 42/18639 0.238095238095238 2.59979914637208 0.00388882461536938 0.0366118610129898 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/1707 36/18639 0.25 2.72978910369069 0.00427819645770887 0.039952834661507 GO:0046975 histone H3K36 methyltransferase activity 5/1707 13/18639 0.384615384615385 4.19967554413952 0.00440201697006163 0.0404566321534235 GO:0140852 histone ubiquitin ligase activity 5/1707 13/18639 0.384615384615385 4.19967554413952 0.00440201697006163 0.0404566321534235 GO:0031624 ubiquitin conjugating enzyme binding 8/1707 30/18639 0.266666666666667 2.91177504393673 0.00455002698512675 0.040530240375206 GO:0032452 histone demethylase activity 8/1707 30/18639 0.266666666666667 2.91177504393673 0.00455002698512675 0.040530240375206 GO:0051721 protein phosphatase 2A binding 8/1707 30/18639 0.266666666666667 2.91177504393673 0.00455002698512675 0.040530240375206 GO:0070566 adenylyltransferase activity 8/1707 30/18639 0.266666666666667 2.91177504393673 0.00455002698512675 0.040530240375206 GO:0008200 ion channel inhibitor activity 10/1707 43/18639 0.232558139534884 2.53933870110761 0.00465937245215148 0.0411874297678734 GO:0001046 core promoter sequence-specific DNA binding 10/1707 44/18639 0.227272727272727 2.48162645790062 0.00554495818759199 0.0486444059184207 GO:0140457 protein demethylase activity 8/1707 31/18639 0.258064516129032 2.81784681671297 0.0056490494990413 0.0491849572924047 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 7/1707 25/18639 0.28 3.05736379613357 0.00585593172718016 0.0506057383587658 GO:0071933 Arp2/3 complex binding 5/1707 14/18639 0.357142857142857 3.89969871955812 0.00633657758940418 0.0543537544335558 GO:0003678 DNA helicase activity 14/1707 74/18639 0.189189189189189 2.0657863487389 0.00670111385202927 0.0570580135341904 GO:0003697 single-stranded DNA binding 20/1707 121/18639 0.165289256198347 1.80481924210954 0.00677757317433686 0.0572878082911101 GO:0019210 kinase inhibitor activity 16/1707 90/18639 0.177777777777778 1.94118336262449 0.00727938994466165 0.0610835764921608 GO:0052742 phosphatidylinositol kinase activity 7/1707 26/18639 0.269230769230769 2.93977288089766 0.00739111822608129 0.0615749273798714 GO:0003725 double-stranded RNA binding 14/1707 75/18639 0.186666666666667 2.03824253075571 0.00756226603027919 0.062550743307595 GO:0005246 calcium channel regulator activity 11/1707 53/18639 0.207547169811321 2.26624001061114 0.00764982223305706 0.0628261996161708 GO:0030295 protein kinase activator activity 22/1707 139/18639 0.158273381294964 1.7282118066531 0.00783691940274699 0.0639095258336691 GO:0001221 transcription coregulator binding 19/1707 115/18639 0.165217391304348 1.80403453809124 0.00821369606968157 0.0665137066342046 GO:0017022 myosin binding 14/1707 76/18639 0.184210526315789 2.01142355008787 0.00850897990933063 0.0684263801042005 GO:0032451 demethylase activity 9/1707 40/18639 0.225 2.45681019332162 0.00891788088470264 0.0692665059177488 GO:0061749 forked DNA-dependent helicase activity 10/1707 47/18639 0.212765957446809 2.32322476909846 0.009004228693967 0.0692665059177488 GO:0140938 histone H3 methyltransferase activity 10/1707 47/18639 0.212765957446809 2.32322476909846 0.009004228693967 0.0692665059177488 GO:0008266 poly(U) RNA binding 7/1707 27/18639 0.259259259259259 2.83089240382738 0.00920458150619141 0.0692665059177488 GO:0005522 profilin binding 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0015924 mannosyl-oligosaccharide mannosidase activity 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0050815 phosphoserine residue binding 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0051864 histone H3K36 demethylase activity 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0099122 RNA polymerase II C-terminal domain binding 4/1707 10/18639 0.4 4.3676625659051 0.00937450056523371 0.0692665059177488 GO:0003735 structural constituent of ribosome 26/1707 175/18639 0.148571428571429 1.62227466733618 0.00939105477468615 0.0692665059177488 GO:0004721 phosphoprotein phosphatase activity 26/1707 175/18639 0.148571428571429 1.62227466733618 0.00939105477468615 0.0692665059177488 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/1707 21/18639 0.285714285714286 3.1197589756465 0.00951180390975955 0.0692746473427771 GO:0035613 RNA stem-loop binding 6/1707 21/18639 0.285714285714286 3.1197589756465 0.00951180390975955 0.0692746473427771 GO:0008094 ATP-dependent activity, acting on DNA 30/1707 210/18639 0.142857142857143 1.55987948782325 0.00966092453063391 0.0699209412904629 GO:0042578 phosphoric ester hydrolase activity 47/1707 363/18639 0.129476584022039 1.41377507298581 0.00974851091506205 0.070116618879763 GO:1990782 protein tyrosine kinase binding 19/1707 117/18639 0.162393162393162 1.77319634085891 0.00985194169015328 0.0704231387481327 GO:0016791 phosphatase activity 37/1707 273/18639 0.135531135531136 1.47988566793488 0.0102376583372984 0.0725553340513823 GO:0009378 four-way junction helicase activity 10/1707 48/18639 0.208333333333333 2.27482425307557 0.0104635067241631 0.0725553340513823 GO:0032266 phosphatidylinositol-3-phosphate binding 10/1707 48/18639 0.208333333333333 2.27482425307557 0.0104635067241631 0.0725553340513823 GO:0036121 double-stranded DNA helicase activity 10/1707 48/18639 0.208333333333333 2.27482425307557 0.0104635067241631 0.0725553340513823 GO:0140693 molecular condensate scaffold activity 10/1707 48/18639 0.208333333333333 2.27482425307557 0.0104635067241631 0.0725553340513823 GO:0015631 tubulin binding 49/1707 385/18639 0.127272727272727 1.38971081642435 0.0115067062835702 0.0793140825974658 GO:0015923 mannosidase activity 5/1707 16/18639 0.3125 3.41223637961336 0.0118465428761409 0.0811733529619597 GO:0140517 protein-RNA adaptor activity 6/1707 22/18639 0.272727272727273 2.97795174948075 0.0120849482800007 0.0818548954345768 GO:0005154 epidermal growth factor receptor binding 8/1707 35/18639 0.228571428571429 2.4958071805172 0.0121498956917237 0.0818548954345768 GO:0008276 protein methyltransferase activity 16/1707 95/18639 0.168421052631579 1.8390158172232 0.012158067370248 0.0818548954345768 GO:0005200 structural constituent of cytoskeleton 18/1707 112/18639 0.160714285714286 1.75486442380116 0.0130604242104061 0.0874217990500015 GO:0032050 clathrin heavy chain binding 4/1707 11/18639 0.363636363636364 3.970602332641 0.0136761988626429 0.0904973616168025 GO:0070990 snRNP binding 4/1707 11/18639 0.363636363636364 3.970602332641 0.0136761988626429 0.0904973616168025 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/1707 29/18639 0.241379310344828 2.63565844494273 0.0137733471638134 0.0906223637255447 GO:0005516 calmodulin binding 29/1707 207/18639 0.140096618357488 1.52973688902473 0.0139412047606165 0.0912085599592876 GO:0004386 helicase activity 23/1707 155/18639 0.148387096774194 1.62026191960996 0.0141471503375859 0.0920359555669916 GO:0048156 tau protein binding 9/1707 43/18639 0.209302325581395 2.28540483099685 0.0143580487396968 0.0928861477126751 GO:0003727 single-stranded RNA binding 15/1707 89/18639 0.168539325842697 1.84030726091507 0.0147891606017619 0.0951435998713349 GO:0017116 single-stranded DNA helicase activity 11/1707 58/18639 0.189655172413793 2.070874492455 0.0150152760814815 0.0960645839909148 GO:0005158 insulin receptor binding 6/1707 23/18639 0.260869565217391 2.84847558645985 0.0151106484581237 0.0961435764533364 GO:0140767 enzyme-substrate adaptor activity 21/1707 139/18639 0.151079136690647 1.6496567245325 0.0152949757249642 0.096784600489118 GO:0031489 myosin V binding 5/1707 17/18639 0.294117647058824 3.21151659257728 0.0155404321406968 0.0978033718419937 GO:0008187 poly-pyrimidine tract binding 7/1707 30/18639 0.233333333333333 2.54780316344464 0.0165804446095006 0.103784620852982 GO:0035035 histone acetyltransferase binding 6/1707 24/18639 0.25 2.72978910369069 0.018623557084508 0.115326626223852 GO:0070300 phosphatidic acid binding 6/1707 24/18639 0.25 2.72978910369069 0.018623557084508 0.115326626223852 GO:0005049 nuclear export signal receptor activity 4/1707 12/18639 0.333333333333333 3.63971880492091 0.0190502908244755 0.115445205441539 GO:0005165 neurotrophin receptor binding 4/1707 12/18639 0.333333333333333 3.63971880492091 0.0190502908244755 0.115445205441539 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/1707 12/18639 0.333333333333333 3.63971880492091 0.0190502908244755 0.115445205441539 GO:1990817 poly(A) RNA polymerase activity 4/1707 12/18639 0.333333333333333 3.63971880492091 0.0190502908244755 0.115445205441539 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/1707 45/18639 0.2 2.18383128295255 0.019141173959219 0.115445205441539 GO:1990841 promoter-specific chromatin binding 12/1707 68/18639 0.176470588235294 1.92690995554637 0.0196627536446984 0.117456983300561 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 8/1707 38/18639 0.210526315789474 2.298769771529 0.0197790256853276 0.117456983300561 GO:0042162 telomeric DNA binding 8/1707 38/18639 0.210526315789474 2.298769771529 0.0197790256853276 0.117456983300561 GO:0000400 four-way junction DNA binding 5/1707 18/18639 0.277777777777778 3.03309900410076 0.0199294108840229 0.117746213284176 GO:0019905 syntaxin binding 11/1707 61/18639 0.180327868852459 1.96902820594082 0.0214554881722959 0.126119062454409 GO:0042826 histone deacetylase binding 19/1707 127/18639 0.149606299212598 1.63357458173616 0.0223352112982642 0.130627144865606 GO:0008139 nuclear localization sequence binding 6/1707 25/18639 0.24 2.62059753954306 0.0226554387762958 0.131834161321359 GO:0016779 nucleotidyltransferase activity 20/1707 136/18639 0.147058823529412 1.60575829628864 0.0230370374160286 0.132720842426672 GO:0140789 histone phosphatase activity 20/1707 136/18639 0.147058823529412 1.60575829628864 0.0230370374160286 0.132720842426672 GO:0022884 macromolecule transmembrane transporter activity 7/1707 32/18639 0.21875 2.38856546572935 0.0233611014262997 0.133261849515542 GO:0140142 nucleocytoplasmic carrier activity 7/1707 32/18639 0.21875 2.38856546572935 0.0233611014262997 0.133261849515542 GO:0097110 scaffold protein binding 12/1707 70/18639 0.171428571428571 1.8718553853879 0.0242841803110243 0.137848435294932 GO:0042800 histone H3K4 methyltransferase activity 5/1707 19/18639 0.263157894736842 2.87346221441125 0.0250566035484111 0.141539253214927 GO:0004535 poly(A)-specific ribonuclease activity 4/1707 13/18639 0.307692307692308 3.35974043531161 0.0255606347597706 0.142303918518338 GO:0019855 calcium channel inhibitor activity 4/1707 13/18639 0.307692307692308 3.35974043531161 0.0255606347597706 0.142303918518338 GO:0140333 glycerophospholipid flippase activity 4/1707 13/18639 0.307692307692308 3.35974043531161 0.0255606347597706 0.142303918518338 GO:0004532 RNA exonuclease activity 8/1707 40/18639 0.2 2.18383128295255 0.0264528040503316 0.145177000427886 GO:0061791 GTPase motor activity 8/1707 40/18639 0.2 2.18383128295255 0.0264528040503316 0.145177000427886 GO:1990606 membrane scission GTPase motor activity 8/1707 40/18639 0.2 2.18383128295255 0.0264528040503316 0.145177000427886 GO:0046332 SMAD binding 13/1707 79/18639 0.164556962025316 1.7968232074926 0.0266690825133136 0.145673573351024 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/1707 48/18639 0.1875 2.04734182776801 0.0283328864774529 0.154035129299955 GO:0003924 GTPase activity 41/1707 331/18639 0.123867069486405 1.35252390636034 0.0288882928408274 0.156320762194758 GO:0016887 ATP hydrolysis activity 50/1707 417/18639 0.119904076738609 1.30925136867659 0.0294937108122001 0.158854498235013 GO:0004713 protein tyrosine kinase activity 20/1707 140/18639 0.142857142857143 1.55987948782325 0.0303994635150622 0.162974901622417 GO:0140658 ATP-dependent chromatin remodeler activity 22/1707 158/18639 0.139240506329114 1.52038886787836 0.0311471344577397 0.1662137405625 GO:0140104 molecular carrier activity 32/1707 249/18639 0.1285140562249 1.40326508141529 0.0316372549917078 0.168054776515585 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 6/1707 27/18639 0.222222222222222 2.42647920328061 0.0323862073514084 0.171247616954022 GO:0008170 N-methyltransferase activity 15/1707 98/18639 0.153061224489796 1.67129945123919 0.0328566496597459 0.172945455936299 GO:0032454 histone H3K9 demethylase activity 4/1707 14/18639 0.285714285714286 3.1197589756465 0.0332502576279172 0.173440533032108 GO:0046030 inositol trisphosphate phosphatase activity 4/1707 14/18639 0.285714285714286 3.1197589756465 0.0332502576279172 0.173440533032108 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 13/1707 82/18639 0.158536585365854 1.73108577307214 0.0350160894531029 0.18183242863988 GO:0000175 3'-5'-RNA exonuclease activity 7/1707 35/18639 0.2 2.18383128295255 0.0367625162882971 0.189204417163769 GO:0010485 histone H4 acetyltransferase activity 7/1707 35/18639 0.2 2.18383128295255 0.0367625162882971 0.189204417163769 GO:0036408 histone H3K14 acetyltransferase activity 6/1707 28/18639 0.214285714285714 2.33981923173487 0.0381306607050873 0.195377456179164 GO:0061775 cohesin loader activity 21/1707 153/18639 0.137254901960784 1.49870774320273 0.0396069839329412 0.20204796208963 GO:0042054 histone methyltransferase activity 11/1707 67/18639 0.164179104477612 1.79269732182672 0.0400456172876068 0.203389582539687 GO:0005048 signal sequence binding 9/1707 51/18639 0.176470588235294 1.92690995554637 0.0402454186379256 0.203511767610122 GO:0019783 ubiquitin-like protein peptidase activity 18/1707 127/18639 0.141732283464567 1.5475969721711 0.0411851588233471 0.20517484125824 GO:0004860 protein kinase inhibitor activity 13/1707 84/18639 0.154761904761905 1.68986944514185 0.0415272632579044 0.20517484125824 GO:0004559 alpha-mannosidase activity 4/1707 15/18639 0.266666666666667 2.91177504393673 0.0421421828235089 0.20517484125824 GO:0042809 nuclear vitamin D receptor binding 4/1707 15/18639 0.266666666666667 2.91177504393673 0.0421421828235089 0.20517484125824 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/1707 15/18639 0.266666666666667 2.91177504393673 0.0421421828235089 0.20517484125824 GO:0055106 ubiquitin-protein transferase regulator activity 7/1707 36/18639 0.194444444444444 2.12316930287053 0.0421606178644345 0.20517484125824 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 18/1707 128/18639 0.140625 1.53550637082601 0.0439882683591079 0.20517484125824 GO:0001223 transcription coactivator binding 8/1707 44/18639 0.181818181818182 1.9853011663205 0.0441709415216743 0.20517484125824 GO:0003785 actin monomer binding 6/1707 29/18639 0.206896551724138 2.25913580995091 0.0444847424984631 0.20517484125824 GO:0010484 histone H3 acetyltransferase activity 6/1707 29/18639 0.206896551724138 2.25913580995091 0.0444847424984631 0.20517484125824 GO:0030159 signaling receptor complex adaptor activity 9/1707 52/18639 0.173076923076923 1.88985399486278 0.0448705991671514 0.20517484125824 GO:0032931 histone H3K56 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0043992 histone H3K9 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0043993 histone H3K18 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0043994 histone H3K23 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0043999 histone H2AK5 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044012 histone H2AK9 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044014 histone H2BK5 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044015 histone H2BK12 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044016 histone H3K4 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044017 histone H3K27 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0044018 histone H3K36 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0046972 histone H4K16 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0070034 telomerase RNA binding 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0140035 ubiquitin-like protein reader activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0140908 histone H3K122 acetyltransferase activity 5/1707 22/18639 0.227272727272727 2.48162645790062 0.0451809883599751 0.20517484125824 GO:0004722 protein serine/threonine phosphatase activity 15/1707 103/18639 0.145631067961165 1.5901684099169 0.0480535037566945 0.217044868226121 GO:0016279 protein-lysine N-methyltransferase activity 11/1707 69/18639 0.159420289855072 1.74073508061435 0.0481697160052791 0.217044868226121 GO:0043995 histone H4K5 acetyltransferase activity 6/1707 30/18639 0.2 2.18383128295255 0.0514608169707038 0.22919856173875 GO:0043996 histone H4K8 acetyltransferase activity 6/1707 30/18639 0.2 2.18383128295255 0.0514608169707038 0.22919856173875 GO:0043997 histone H4K12 acetyltransferase activity 6/1707 30/18639 0.2 2.18383128295255 0.0514608169707038 0.22919856173875 GO:0140327 flippase activity 4/1707 16/18639 0.25 2.72978910369069 0.0522407294726317 0.230896048585143 GO:0140328 floppase activity 4/1707 16/18639 0.25 2.72978910369069 0.0522407294726317 0.230896048585143 GO:0016278 lysine N-methyltransferase activity 11/1707 70/18639 0.157142857142857 1.71586743660557 0.0526229514736995 0.231701056298646 GO:0044013 histone H2B acetyltransferase activity 5/1707 23/18639 0.217391304347826 2.3737296553832 0.0535338605549338 0.233932869896654 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/1707 23/18639 0.217391304347826 2.3737296553832 0.0535338605549338 0.233932869896654 GO:0000146 microfilament motor activity 7/1707 38/18639 0.184210526315789 2.01142355008787 0.0544293375716022 0.236951777849306 GO:0043021 ribonucleoprotein complex binding 23/1707 177/18639 0.129943502824859 1.4188734324268 0.0550285755412472 0.2386632602126 GO:0016247 channel regulator activity 22/1707 168/18639 0.130952380952381 1.42988953050464 0.0555638145459678 0.240085437478473 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/1707 10/18639 0.3 3.27574692442882 0.056402867691076 0.241905632541726 GO:1905394 retromer complex binding 3/1707 10/18639 0.3 3.27574692442882 0.056402867691076 0.241905632541726 GO:0004197 cysteine-type endopeptidase activity 13/1707 88/18639 0.147727272727273 1.61305719763541 0.0570060524778066 0.2435904382631 GO:0005525 GTP binding 44/1707 378/18639 0.116402116402116 1.27101291600413 0.0584165053997429 0.248699681076847 GO:0099106 ion channel regulator activity 21/1707 160/18639 0.13125 1.43313927943761 0.0591465513130507 0.249132741629535 GO:0000510 H3-H4 histone complex chaperone activity 20/1707 151/18639 0.132450331125828 1.44624588275003 0.0595939286972204 0.249132741629535 GO:0140584 chromatin extrusion motor activity 20/1707 151/18639 0.132450331125828 1.44624588275003 0.0595939286972204 0.249132741629535 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 20/1707 151/18639 0.132450331125828 1.44624588275003 0.0595939286972204 0.249132741629535 GO:0140849 ATP-dependent H2AZ histone chaperone activity 20/1707 151/18639 0.132450331125828 1.44624588275003 0.0595939286972204 0.249132741629535 GO:0046982 protein heterodimerization activity 43/1707 369/18639 0.116531165311653 1.27242202123251 0.0598939866648483 0.249486462438469 GO:0043495 protein-membrane adaptor activity 8/1707 47/18639 0.170212765957447 1.85857981527876 0.0616466849073003 0.25157647461306 GO:0141108 transporter regulator activity 22/1707 170/18639 0.129411764705882 1.413067300734 0.0617359609839085 0.25157647461306 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/1707 24/18639 0.208333333333333 2.27482425307557 0.0627207825208353 0.25157647461306 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/1707 24/18639 0.208333333333333 2.27482425307557 0.0627207825208353 0.25157647461306 GO:0030552 cAMP binding 5/1707 24/18639 0.208333333333333 2.27482425307557 0.0627207825208353 0.25157647461306 GO:0043998 histone H2A acetyltransferase activity 5/1707 24/18639 0.208333333333333 2.27482425307557 0.0627207825208353 0.25157647461306 GO:0015616 DNA translocase activity 20/1707 152/18639 0.131578947368421 1.43673110720562 0.0629778328655941 0.25157647461306 GO:0140674 ATP-dependent histone chaperone activity 20/1707 152/18639 0.131578947368421 1.43673110720562 0.0629778328655941 0.25157647461306 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/1707 17/18639 0.235294117647059 2.56921327406182 0.0635331286516885 0.25157647461306 GO:0032183 SUMO binding 4/1707 17/18639 0.235294117647059 2.56921327406182 0.0635331286516885 0.25157647461306 GO:0030971 receptor tyrosine kinase binding 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0033192 calmodulin-dependent protein phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0140791 histone H2AXS140 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:1990439 MAP kinase serine/threonine phosphatase activity 12/1707 81/18639 0.148148148148148 1.61765280218707 0.0645234999655257 0.25157647461306 GO:0033549 MAP kinase phosphatase activity 12/1707 82/18639 0.146341463414634 1.59792532898967 0.0695819131962268 0.270388776782653 GO:0120013 lipid transfer activity 10/1707 65/18639 0.153846153846154 1.67987021765581 0.0705621145814914 0.273280697944371 GO:0008526 phosphatidylinositol transfer activity 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0015173 aromatic amino acid transmembrane transporter activity 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0019107 myristoyltransferase activity 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0034056 estrogen response element binding 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0042608 T cell receptor binding 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0050998 nitric-oxide synthase binding 3/1707 11/18639 0.272727272727273 2.97795174948075 0.0724253685017385 0.273318956008196 GO:0004709 MAP kinase kinase kinase activity 5/1707 25/18639 0.2 2.18383128295255 0.0727371184569701 0.273318956008196 GO:0017056 structural constituent of nuclear pore 5/1707 25/18639 0.2 2.18383128295255 0.0727371184569701 0.273318956008196 GO:0140713 histone chaperone activity 21/1707 164/18639 0.128048780487805 1.39818466286596 0.0729322602819797 0.273318956008196 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 12/1707 83/18639 0.144578313253012 1.5786732165922 0.0748904046879751 0.278126087842283 GO:0030165 PDZ domain binding 12/1707 83/18639 0.144578313253012 1.5786732165922 0.0748904046879751 0.278126087842283 GO:0008525 phosphatidylcholine transporter activity 4/1707 18/18639 0.222222222222222 2.42647920328061 0.0759913337281644 0.278126087842283 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 4/1707 18/18639 0.222222222222222 2.42647920328061 0.0759913337281644 0.278126087842283 GO:0070064 proline-rich region binding 4/1707 18/18639 0.222222222222222 2.42647920328061 0.0759913337281644 0.278126087842283 GO:0098641 cadherin binding involved in cell-cell adhesion 4/1707 18/18639 0.222222222222222 2.42647920328061 0.0759913337281644 0.278126087842283 GO:0140311 protein sequestering activity 6/1707 33/18639 0.181818181818182 1.9853011663205 0.0761796490268134 0.278126087842283 GO:0001727 lipid kinase activity 7/1707 41/18639 0.170731707317073 1.86424621715461 0.0766167720394545 0.278126087842283 GO:0008137 NADH dehydrogenase (ubiquinone) activity 7/1707 41/18639 0.170731707317073 1.86424621715461 0.0766167720394545 0.278126087842283 GO:0042287 MHC protein binding 7/1707 41/18639 0.170731707317073 1.86424621715461 0.0766167720394545 0.278126087842283 GO:0008408 3'-5' exonuclease activity 9/1707 58/18639 0.155172413793103 1.69435185746318 0.0799960187509658 0.289485592855058 GO:0017018 myosin phosphatase activity 12/1707 84/18639 0.142857142857143 1.55987948782325 0.0804509282596536 0.290224844002115 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/1707 26/18639 0.192307692307692 2.09983777206976 0.0835710192940202 0.296856565467716 GO:0005160 transforming growth factor beta receptor binding 5/1707 26/18639 0.192307692307692 2.09983777206976 0.0835710192940202 0.296856565467716 GO:0008157 protein phosphatase 1 binding 5/1707 26/18639 0.192307692307692 2.09983777206976 0.0835710192940202 0.296856565467716 GO:0043548 phosphatidylinositol 3-kinase binding 5/1707 26/18639 0.192307692307692 2.09983777206976 0.0835710192940202 0.296856565467716 GO:0050681 nuclear androgen receptor binding 5/1707 26/18639 0.192307692307692 2.09983777206976 0.0835710192940202 0.296856565467716 GO:0004402 histone acetyltransferase activity 7/1707 42/18639 0.166666666666667 1.81985940246046 0.0850305899102895 0.301117501884144 GO:0052866 phosphatidylinositol phosphate phosphatase activity 6/1707 34/18639 0.176470588235294 1.92690995554637 0.0856810040677771 0.30194033730762 GO:0001786 phosphatidylserine binding 9/1707 59/18639 0.152542372881356 1.66563402937059 0.0871153653908548 0.30194033730762 GO:0005520 insulin-like growth factor binding 4/1707 19/18639 0.210526315789474 2.298769771529 0.0895739284427653 0.30194033730762 GO:0050145 nucleoside monophosphate kinase activity 4/1707 19/18639 0.210526315789474 2.298769771529 0.0895739284427653 0.30194033730762 GO:0140036 ubiquitin-modified protein reader activity 4/1707 19/18639 0.210526315789474 2.298769771529 0.0895739284427653 0.30194033730762 GO:1990380 K48-linked deubiquitinase activity 4/1707 19/18639 0.210526315789474 2.298769771529 0.0895739284427653 0.30194033730762 GO:0005548 phospholipid transporter activity 10/1707 68/18639 0.147058823529412 1.60575829628864 0.0898382903544327 0.30194033730762 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 10/1707 68/18639 0.147058823529412 1.60575829628864 0.0898382903544327 0.30194033730762 GO:0005078 MAP-kinase scaffold activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0005095 GTPase inhibitor activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0016273 arginine N-methyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0016274 protein-arginine N-methyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0017166 vinculin binding 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0035259 nuclear glucocorticoid receptor binding 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0070410 co-SMAD binding 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/1707 12/18639 0.25 2.72978910369069 0.090217061060826 0.30194033730762 GO:0003689 DNA clamp loader activity 20/1707 160/18639 0.125 1.36489455184534 0.0948638816486953 0.315891553618414 GO:0008320 protein transmembrane transporter activity 5/1707 27/18639 0.185185185185185 2.02206600273384 0.0952039310991593 0.315891553618414 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/1707 27/18639 0.185185185185185 2.02206600273384 0.0952039310991593 0.315891553618414 GO:0002039 p53 binding 10/1707 69/18639 0.144927536231884 1.58248643692214 0.0969007605831027 0.320603087872094 GO:0005080 protein kinase C binding 8/1707 52/18639 0.153846153846154 1.67987021765581 0.0992068804799682 0.327297913378356 GO:0003954 NADH dehydrogenase activity 7/1707 44/18639 0.159090909090909 1.73713852053044 0.103366938701179 0.340053735840811 GO:0042288 MHC class I protein binding 4/1707 20/18639 0.2 2.18383128295255 0.104228058212338 0.340949410762394 GO:0052745 inositol phosphate phosphatase activity 4/1707 20/18639 0.2 2.18383128295255 0.104228058212338 0.340949410762394 GO:0051019 mitogen-activated protein kinase binding 5/1707 28/18639 0.178571428571429 1.94984935977906 0.107611163793523 0.350038560878931 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/1707 28/18639 0.178571428571429 1.94984935977906 0.107611163793523 0.350038560878931 GO:0002161 aminoacyl-tRNA editing activity 3/1707 13/18639 0.230769230769231 2.51980532648371 0.109613988951143 0.35161495624771 GO:0043560 insulin receptor substrate binding 3/1707 13/18639 0.230769230769231 2.51980532648371 0.109613988951143 0.35161495624771 GO:0046974 histone H3K9 methyltransferase activity 3/1707 13/18639 0.230769230769231 2.51980532648371 0.109613988951143 0.35161495624771 GO:0070123 transforming growth factor beta receptor activity, type III 3/1707 13/18639 0.230769230769231 2.51980532648371 0.109613988951143 0.35161495624771 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/1707 13/18639 0.230769230769231 2.51980532648371 0.109613988951143 0.35161495624771 GO:0030527 structural constituent of chromatin 13/1707 98/18639 0.13265306122449 1.4484595244073 0.111268690228188 0.355936859901219 GO:0000049 tRNA binding 11/1707 80/18639 0.1375 1.50138400702988 0.112357053799343 0.35842828732683 GO:0051539 4 iron, 4 sulfur cluster binding 7/1707 45/18639 0.155555555555556 1.69853544229643 0.113274546301459 0.359375135937233 GO:0140303 intramembrane lipid transporter activity 7/1707 45/18639 0.155555555555556 1.69853544229643 0.113274546301459 0.359375135937233 GO:0019001 guanyl nucleotide binding 44/1707 400/18639 0.11 1.2011072056239 0.116080234515581 0.366108984363499 GO:0032561 guanyl ribonucleotide binding 44/1707 400/18639 0.11 1.2011072056239 0.116080234515581 0.366108984363499 GO:0002020 protease binding 17/1707 136/18639 0.125 1.36489455184534 0.116345514892718 0.366108984363499 GO:0140312 cargo adaptor activity 4/1707 21/18639 0.19047619047619 2.07983931709767 0.119891328128401 0.375339373780965 GO:0005518 collagen binding 10/1707 72/18639 0.138888888888889 1.51654950205038 0.119981053912019 0.375339373780965 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5/1707 29/18639 0.172413793103448 1.88261317495909 0.120762501563327 0.375339373780965 GO:0097472 cyclin-dependent protein kinase activity 5/1707 29/18639 0.172413793103448 1.88261317495909 0.120762501563327 0.375339373780965 GO:0022853 active monoatomic ion transmembrane transporter activity 15/1707 118/18639 0.127118644067797 1.38802835780882 0.120899470138428 0.375339373780965 GO:0140313 molecular sequestering activity 8/1707 55/18639 0.145454545454545 1.5882409330564 0.126763059773675 0.392490971170896 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 20/1707 167/18639 0.119760479041916 1.3076834029656 0.13001816441847 0.395418989499415 GO:0004705 JUN kinase activity 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0005545 1-phosphatidylinositol binding 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0008174 mRNA methyltransferase activity 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0042043 neurexin family protein binding 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0061665 SUMO ligase activity 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0070742 C2H2 zinc finger domain binding 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:1990825 sequence-specific mRNA binding 3/1707 14/18639 0.214285714285714 2.33981923173487 0.130440461130204 0.395418989499415 GO:0008234 cysteine-type peptidase activity 22/1707 187/18639 0.117647058823529 1.28460663703091 0.13372035312701 0.402824927550347 GO:0043178 alcohol binding 12/1707 92/18639 0.130434782608696 1.42423779322992 0.13404386188787 0.402824927550347 GO:0070851 growth factor receptor binding 17/1707 139/18639 0.122302158273381 1.33543639605012 0.13417604075878 0.402824927550347 GO:0061733 protein-lysine-acetyltransferase activity 7/1707 47/18639 0.148936170212766 1.62625733836892 0.134513760249385 0.402824927550347 GO:0001968 fibronectin binding 5/1707 30/18639 0.166666666666667 1.81985940246046 0.134622838481852 0.402824927550347 GO:0004857 enzyme inhibitor activity 45/1707 416/18639 0.108173076923077 1.18115874678924 0.136333038487732 0.405571069768943 GO:0008970 phospholipase A1 activity 4/1707 22/18639 0.181818181818182 1.9853011663205 0.136493625854718 0.405571069768943 GO:0019212 phosphatase inhibitor activity 8/1707 56/18639 0.142857142857143 1.55987948782325 0.136748434268558 0.405571069768943 GO:0008017 microtubule binding 31/1707 276/18639 0.11231884057971 1.22642698861466 0.136941527011793 0.405571069768943 GO:0140597 protein carrier chaperone 22/1707 188/18639 0.117021276595745 1.27777362300415 0.139072481089913 0.410831461995201 GO:0004540 RNA nuclease activity 15/1707 121/18639 0.12396694214876 1.35361443158216 0.140653356101212 0.414444240115022 GO:0000217 DNA secondary structure binding 6/1707 39/18639 0.153846153846154 1.67987021765581 0.142182062116914 0.417885350079661 GO:0005164 tumor necrosis factor receptor binding 5/1707 31/18639 0.161290322580645 1.7611542604456 0.149152824982273 0.437263218555626 GO:0010181 FMN binding 3/1707 15/18639 0.2 2.18383128295255 0.152515030706878 0.441531013896412 GO:0017081 chloride channel regulator activity 3/1707 15/18639 0.2 2.18383128295255 0.152515030706878 0.441531013896412 GO:0031386 protein tag activity 3/1707 15/18639 0.2 2.18383128295255 0.152515030706878 0.441531013896412 GO:0120283 protein serine/threonine kinase binding 3/1707 15/18639 0.2 2.18383128295255 0.152515030706878 0.441531013896412 GO:0141047 molecular tag activity 3/1707 15/18639 0.2 2.18383128295255 0.152515030706878 0.441531013896412 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/1707 23/18639 0.173913043478261 1.89898372430656 0.153958839602041 0.443493373779012 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/1707 23/18639 0.173913043478261 1.89898372430656 0.153958839602041 0.443493373779012 GO:0030331 nuclear estrogen receptor binding 6/1707 40/18639 0.15 1.63787346221441 0.155147427846836 0.44470475605603 GO:0050997 quaternary ammonium group binding 6/1707 40/18639 0.15 1.63787346221441 0.155147427846836 0.44470475605603 GO:0003774 cytoskeletal motor activity 18/1707 153/18639 0.117647058823529 1.28460663703091 0.162325201078449 0.464129834194677 GO:0051059 NF-kappaB binding 5/1707 32/18639 0.15625 1.70611818980668 0.164309512876488 0.465771821152393 GO:0070717 poly-purine tract binding 5/1707 32/18639 0.15625 1.70611818980668 0.164309512876488 0.465771821152393 GO:0120015 sterol transfer activity 5/1707 32/18639 0.15625 1.70611818980668 0.164309512876488 0.465771821152393 GO:0051540 metal cluster binding 10/1707 77/18639 0.12987012987013 1.4180722616575 0.164508354793894 0.465771821152393 GO:0101005 deubiquitinase activity 14/1707 115/18639 0.121739130434783 1.32928860701459 0.166501258758073 0.470264530833777 GO:0032934 sterol binding 9/1707 68/18639 0.132352941176471 1.44518246665977 0.167080419103922 0.470752129738056 GO:0042169 SH2 domain binding 6/1707 41/18639 0.146341463414634 1.59792532898967 0.168609825985244 0.472760722738288 GO:0140318 protein transporter activity 6/1707 41/18639 0.146341463414634 1.59792532898967 0.168609825985244 0.472760722738288 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/1707 24/18639 0.166666666666667 1.81985940246046 0.172206451018281 0.480518241636554 GO:0050699 WW domain binding 4/1707 24/18639 0.166666666666667 1.81985940246046 0.172206451018281 0.480518241636554 GO:0000062 fatty-acyl-CoA binding 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0004707 MAP kinase activity 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0004708 MAP kinase kinase activity 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0005024 transforming growth factor beta receptor activity 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0005521 lamin binding 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0030275 LRR domain binding 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0043023 ribosomal large subunit binding 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0097027 ubiquitin-protein transferase activator activity 3/1707 16/18639 0.1875 2.04734182776801 0.175655254068627 0.480871830287164 GO:0015078 proton transmembrane transporter activity 21/1707 185/18639 0.113513513513514 1.23947180924334 0.17925646349267 0.488069901957852 GO:0044325 transmembrane transporter binding 16/1707 136/18639 0.117647058823529 1.28460663703091 0.179562257399773 0.488069901957852 GO:0019956 chemokine binding 5/1707 33/18639 0.151515151515152 1.65441763860042 0.18004698856393 0.488069901957852 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/1707 60/18639 0.133333333333333 1.45588752196837 0.18039198448874 0.488069901957852 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/1707 60/18639 0.133333333333333 1.45588752196837 0.18039198448874 0.488069901957852 GO:0140097 catalytic activity, acting on DNA 36/1707 336/18639 0.107142857142857 1.16990961586744 0.182014753333768 0.491312550956885 GO:0019894 kinesin binding 6/1707 42/18639 0.142857142857143 1.55987948782325 0.182539698664403 0.491583653612509 GO:0016835 carbon-oxygen lyase activity 10/1707 79/18639 0.126582278481013 1.38217169807123 0.184286725143038 0.495136955256701 GO:0004843 cysteine-type deubiquitinase activity 13/1707 108/18639 0.12037037037037 1.314342901777 0.188002633151577 0.503951502753532 GO:0017025 TBP-class protein binding 4/1707 25/18639 0.16 1.74706502636204 0.191152990553769 0.510034937929182 GO:0042974 nuclear retinoic acid receptor binding 4/1707 25/18639 0.16 1.74706502636204 0.191152990553769 0.510034937929182 GO:0048306 calcium-dependent protein binding 10/1707 80/18639 0.125 1.36489455184534 0.194562392477852 0.517938506872074 GO:0008376 acetylgalactosaminyltransferase activity 5/1707 34/18639 0.147058823529412 1.60575829628864 0.196316985890852 0.52021755071306 GO:0030332 cyclin binding 5/1707 34/18639 0.147058823529412 1.60575829628864 0.196316985890852 0.52021755071306 GO:0005319 lipid transporter activity 20/1707 178/18639 0.112359550561798 1.22687150727671 0.198655904947233 0.520790740453511 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:0008429 phosphatidylethanolamine binding 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:0015278 intracellularly gated calcium channel activity 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:0038191 neuropilin binding 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:0051787 misfolded protein binding 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:1901567 fatty acid derivative binding 3/1707 17/18639 0.176470588235294 1.92690995554637 0.199681423800828 0.520790740453511 GO:0004864 protein phosphatase inhibitor activity 7/1707 53/18639 0.132075471698113 1.44215273402527 0.208435529765889 0.538768623814509 GO:0016251 RNA polymerase II general transcription initiation factor activity 7/1707 53/18639 0.132075471698113 1.44215273402527 0.208435529765889 0.538768623814509 GO:0034212 protein N-acetyltransferase activity 7/1707 53/18639 0.132075471698113 1.44215273402527 0.208435529765889 0.538768623814509 GO:0140296 general transcription initiation factor binding 7/1707 53/18639 0.132075471698113 1.44215273402527 0.208435529765889 0.538768623814509 GO:0005112 Notch binding 4/1707 26/18639 0.153846153846154 1.67987021765581 0.210713348964633 0.542235684668989 GO:0120014 phospholipid transfer activity 4/1707 26/18639 0.153846153846154 1.67987021765581 0.210713348964633 0.542235684668989 GO:0019205 nucleobase-containing compound kinase activity 6/1707 44/18639 0.136363636363636 1.48897587474037 0.211674971227466 0.543502476011985 GO:0015485 cholesterol binding 7/1707 54/18639 0.12962962962963 1.41544620191369 0.222028017863724 0.552655641108326 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:0004706 JUN kinase kinase kinase activity 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:0008409 5'-3' exonuclease activity 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:0035615 clathrin adaptor activity 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:0070628 proteasome binding 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:1901611 phosphatidylglycerol binding 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:1990381 ubiquitin-specific protease binding 3/1707 18/18639 0.166666666666667 1.81985940246046 0.224419441815361 0.552655641108326 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 14/1707 122/18639 0.114754098360656 1.25301794923507 0.225751194369777 0.552655641108326 GO:0051213 dioxygenase activity 11/1707 93/18639 0.118279569892473 1.29151312432678 0.229948137885113 0.552655641108326 GO:0005484 SNAP receptor activity 5/1707 36/18639 0.138888888888889 1.51654950205038 0.230253199329719 0.552655641108326 GO:0015252 proton channel activity 4/1707 27/18639 0.148148148148148 1.61765280218707 0.23080194337602 0.552655641108326 GO:0001094 TFIID-class transcription factor complex binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0005131 growth hormone receptor binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0008140 cAMP response element binding protein binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0008239 dipeptidyl-peptidase activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0031419 cobalamin binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0031996 thioesterase binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0042975 peroxisome proliferator activated receptor binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0045322 unmethylated CpG binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0051880 G-quadruplex DNA binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0070097 delta-catenin binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0070513 death domain binding 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0140999 histone H3K4 trimethyltransferase activity 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/1707 10/18639 0.2 2.18383128295255 0.231466309099774 0.552655641108326 GO:0003684 damaged DNA binding 9/1707 74/18639 0.121621621621622 1.32800550990358 0.234352752342084 0.558396064222495 GO:0004527 exonuclease activity 10/1707 84/18639 0.119047619047619 1.29989957318604 0.237990029606116 0.565898263416597 GO:0008168 methyltransferase activity 22/1707 204/18639 0.107843137254902 1.177556083945 0.240436780085451 0.569657283763979 GO:0016410 N-acyltransferase activity 11/1707 94/18639 0.117021276595745 1.27777362300415 0.240554759724167 0.569657283763979 GO:0030291 protein serine/threonine kinase inhibitor activity 6/1707 46/18639 0.130434782608696 1.42423779322992 0.242286340293034 0.572586902161904 GO:0023023 MHC protein complex binding 5/1707 37/18639 0.135135135135135 1.47556167767064 0.247816224195104 0.579471033493413 GO:0030551 cyclic nucleotide binding 5/1707 37/18639 0.135135135135135 1.47556167767064 0.247816224195104 0.579471033493413 GO:0003756 protein disulfide isomerase activity 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0022821 solute:potassium antiporter activity 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0042577 lipid phosphatase activity 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0046624 sphingolipid transporter activity 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0120227 acyl-CoA binding 3/1707 19/18639 0.157894736842105 1.72407732864675 0.249702975572723 0.579471033493413 GO:0019789 SUMO transferase activity 4/1707 28/18639 0.142857142857143 1.55987948782325 0.251333739973103 0.579769862328392 GO:0051959 dynein light intermediate chain binding 4/1707 28/18639 0.142857142857143 1.55987948782325 0.251333739973103 0.579769862328392 GO:0097718 disordered domain specific binding 4/1707 28/18639 0.142857142857143 1.55987948782325 0.251333739973103 0.579769862328392 GO:0035401 histone H3Y41 kinase activity 13/1707 115/18639 0.11304347826087 1.23433942079927 0.253273730743327 0.581926548017406 GO:0140801 histone H2AXY142 kinase activity 13/1707 115/18639 0.11304347826087 1.23433942079927 0.253273730743327 0.581926548017406 GO:0051536 iron-sulfur cluster binding 9/1707 76/18639 0.118421052631579 1.29305799648506 0.258702661022728 0.593223131612512 GO:0008013 beta-catenin binding 12/1707 106/18639 0.113207547169811 1.2361309148788 0.263000920862555 0.594162540996344 GO:0016504 peptidase activator activity 7/1707 57/18639 0.12280701754386 1.34094903339192 0.264504301303526 0.594162540996344 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0002162 dystroglycan binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0005114 type II transforming growth factor beta receptor binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0032404 mismatch repair complex binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0034511 U3 snoRNA binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0034713 type I transforming growth factor beta receptor binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0048185 activin binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0050786 RAGE receptor binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0140031 phosphorylation-dependent protein binding 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:1990948 ubiquitin ligase inhibitor activity 2/1707 11/18639 0.181818181818182 1.9853011663205 0.266808740343781 0.594162540996344 GO:0043236 laminin binding 4/1707 29/18639 0.137931034482759 1.50609053996727 0.272225138118667 0.605060863611163 GO:0000339 RNA cap binding 3/1707 20/18639 0.15 1.63787346221441 0.275375019812791 0.606243864911048 GO:0016004 phospholipase activator activity 3/1707 20/18639 0.15 1.63787346221441 0.275375019812791 0.606243864911048 GO:0030742 GTP-dependent protein binding 3/1707 20/18639 0.15 1.63787346221441 0.275375019812791 0.606243864911048 GO:0061608 nuclear import signal receptor activity 3/1707 20/18639 0.15 1.63787346221441 0.275375019812791 0.606243864911048 GO:0140939 histone H4 methyltransferase activity 3/1707 20/18639 0.15 1.63787346221441 0.275375019812791 0.606243864911048 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/1707 58/18639 0.120689655172414 1.31782922247137 0.27914226533066 0.6133714293224 GO:0140223 general transcription initiation factor activity 8/1707 68/18639 0.117647058823529 1.28460663703091 0.282145731498577 0.618796888400287 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/1707 39/18639 0.128205128205128 1.39989184804651 0.283871722855192 0.62074846897954 GO:0005496 steroid binding 12/1707 108/18639 0.111111111111111 1.2132396016403 0.284257367577205 0.62074846897954 GO:0004725 protein tyrosine phosphatase activity 11/1707 98/18639 0.112244897959184 1.22561959757541 0.284643728003571 0.62074846897954 GO:0016763 pentosyltransferase activity 6/1707 49/18639 0.122448979591837 1.33703956099136 0.290353587897795 0.629250277410127 GO:0031210 phosphatidylcholine binding 4/1707 30/18639 0.133333333333333 1.45588752196837 0.293394722678177 0.629250277410127 GO:0098918 structural constituent of synapse 4/1707 30/18639 0.133333333333333 1.45588752196837 0.293394722678177 0.629250277410127 GO:0008080 N-acetyltransferase activity 8/1707 69/18639 0.115942028985507 1.26598914953771 0.295855680825335 0.629250277410127 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 10/1707 89/18639 0.112359550561798 1.22687150727671 0.296585496207386 0.629250277410127 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 10/1707 89/18639 0.112359550561798 1.22687150727671 0.296585496207386 0.629250277410127 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/1707 21/18639 0.142857142857143 1.55987948782325 0.301288968426855 0.629250277410127 GO:0008373 sialyltransferase activity 3/1707 21/18639 0.142857142857143 1.55987948782325 0.301288968426855 0.629250277410127 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1707 21/18639 0.142857142857143 1.55987948782325 0.301288968426855 0.629250277410127 GO:0000340 RNA 7-methylguanosine cap binding 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0004300 enoyl-CoA hydratase activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0005025 transforming growth factor beta receptor activity, type I 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0005026 transforming growth factor beta receptor activity, type II 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0015132 prostaglandin transmembrane transporter activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0016361 activin receptor activity, type I 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0016362 activin receptor activity, type II 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0017002 activin receptor activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0035497 cAMP response element binding 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0070008 serine-type exopeptidase activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0097371 MDM2/MDM4 family protein binding 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:1990459 transferrin receptor binding 2/1707 12/18639 0.166666666666667 1.81985940246046 0.302127076200372 0.629250277410127 GO:0140793 histone H2AXY142 phosphatase activity 10/1707 90/18639 0.111111111111111 1.2132396016403 0.308746852447489 0.641883043328891 GO:0008327 methyl-CpG binding 4/1707 31/18639 0.129032258064516 1.40892340835648 0.3147638927072 0.652051140885398 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1707 31/18639 0.129032258064516 1.40892340835648 0.3147638927072 0.652051140885398 GO:0017080 sodium channel regulator activity 5/1707 41/18639 0.121951219512195 1.33160444082472 0.320823558116267 0.663417286247567 GO:0003743 translation initiation factor activity 6/1707 51/18639 0.117647058823529 1.28460663703091 0.323413047490318 0.665629924806494 GO:0016597 amino acid binding 6/1707 51/18639 0.117647058823529 1.28460663703091 0.323413047490318 0.665629924806494 GO:0015026 coreceptor activity 7/1707 61/18639 0.114754098360656 1.25301794923507 0.324120292324433 0.665629924806494 GO:0016741 transferase activity, transferring one-carbon groups 22/1707 215/18639 0.102325581395349 1.11730902848735 0.324192813118189 0.665629924806494 GO:0004407 histone deacetylase activity 3/1707 22/18639 0.136363636363636 1.48897587474037 0.327309285675087 0.667296043682659 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/1707 22/18639 0.136363636363636 1.48897587474037 0.327309285675087 0.667296043682659 GO:0031683 G-protein beta/gamma-subunit complex binding 3/1707 22/18639 0.136363636363636 1.48897587474037 0.327309285675087 0.667296043682659 GO:0033558 protein lysine deacetylase activity 3/1707 22/18639 0.136363636363636 1.48897587474037 0.327309285675087 0.667296043682659 GO:0031369 translation initiation factor binding 4/1707 32/18639 0.125 1.36489455184534 0.336257375540158 0.678949408175425 GO:0043425 bHLH transcription factor binding 4/1707 32/18639 0.125 1.36489455184534 0.336257375540158 0.678949408175425 GO:0031432 titin binding 2/1707 13/18639 0.153846153846154 1.67987021765581 0.337129455700233 0.678949408175425 GO:0031994 insulin-like growth factor I binding 2/1707 13/18639 0.153846153846154 1.67987021765581 0.337129455700233 0.678949408175425 GO:0035673 oligopeptide transmembrane transporter activity 2/1707 13/18639 0.153846153846154 1.67987021765581 0.337129455700233 0.678949408175425 GO:0045159 myosin II binding 2/1707 13/18639 0.153846153846154 1.67987021765581 0.337129455700233 0.678949408175425 GO:0071714 icosanoid transmembrane transporter activity 2/1707 13/18639 0.153846153846154 1.67987021765581 0.337129455700233 0.678949408175425 GO:0019955 cytokine binding 15/1707 144/18639 0.104166666666667 1.13741212653779 0.339580293071336 0.682697880862165 GO:0015399 primary active transmembrane transporter activity 17/1707 166/18639 0.102409638554217 1.11822686175281 0.35116520847379 0.701775515085144 GO:0008171 O-methyltransferase activity 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0017134 fibroblast growth factor binding 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0042171 lysophosphatidic acid acyltransferase activity 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0071617 lysophospholipid acyltransferase activity 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0099186 structural constituent of postsynapse 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0140103 catalytic activity, acting on a glycoprotein 3/1707 23/18639 0.130434782608696 1.42423779322992 0.353311852586044 0.701775515085144 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/1707 33/18639 0.121212121212121 1.32353411088033 0.35780363581274 0.709199512472022 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1707 43/18639 0.116279069767442 1.26966935055381 0.358274365108923 0.709199512472022 GO:0051117 ATPase binding 9/1707 84/18639 0.107142857142857 1.16990961586744 0.362333180517934 0.716009936927931 GO:0015085 calcium ion transmembrane transporter activity 15/1707 147/18639 0.102040816326531 1.11419963415946 0.369671138405007 0.717144809421474 GO:0005161 platelet-derived growth factor receptor binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0008195 phosphatidate phosphatase activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0008474 palmitoyl-(protein) hydrolase activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0015386 potassium:proton antiporter activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0019992 diacylglycerol binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0032036 myosin heavy chain binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0034236 protein kinase A catalytic subunit binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0044548 S100 protein binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0098599 palmitoyl hydrolase activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0098821 BMP receptor activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:1901474 azole transmembrane transporter activity 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:1901612 cardiolipin binding 2/1707 14/18639 0.142857142857143 1.55987948782325 0.371577621461904 0.717144809421474 GO:0017069 snRNA binding 6/1707 54/18639 0.111111111111111 1.2132396016403 0.373819791363688 0.719173179848537 GO:0016829 lyase activity 20/1707 200/18639 0.1 1.09191564147627 0.37387068589708 0.719173179848537 GO:0060229 lipase activator activity 3/1707 24/18639 0.125 1.36489455184534 0.37918405281001 0.726978697274821 GO:0070840 dynein complex binding 3/1707 24/18639 0.125 1.36489455184534 0.37918405281001 0.726978697274821 GO:0098632 cell-cell adhesion mediator activity 6/1707 55/18639 0.109090909090909 1.1911806997923 0.390705379173299 0.747829469558149 GO:0008235 metalloexopeptidase activity 7/1707 66/18639 0.106060606060606 1.15809234702029 0.401046356221874 0.75940732806524 GO:0008081 phosphoric diester hydrolase activity 9/1707 87/18639 0.103448275862069 1.12956790497546 0.402564263797261 0.75940732806524 GO:0003707 nuclear steroid receptor activity 3/1707 25/18639 0.12 1.31029876977153 0.404824652208589 0.75940732806524 GO:0120020 cholesterol transfer activity 3/1707 25/18639 0.12 1.31029876977153 0.404824652208589 0.75940732806524 GO:0000774 adenyl-nucleotide exchange factor activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0004129 cytochrome-c oxidase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0005523 tropomyosin binding 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0008252 nucleotidase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0015929 hexosaminidase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0045504 dynein heavy chain binding 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0061578 K63-linked deubiquitinase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0141050 histone H3K deacetylase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0141051 histone H4K deacetylase activity 2/1707 15/18639 0.133333333333333 1.45588752196837 0.405279558501139 0.75940732806524 GO:0016651 oxidoreductase activity, acting on NAD(P)H 9/1707 88/18639 0.102272727272727 1.11673190605528 0.416008562738483 0.777909704060233 GO:0050840 extracellular matrix binding 7/1707 67/18639 0.104477611940299 1.140807386617 0.416497423590107 0.777909704060233 GO:0016409 palmitoyltransferase activity 4/1707 36/18639 0.111111111111111 1.2132396016403 0.422105783927923 0.785849674901182 GO:0045505 dynein intermediate chain binding 4/1707 36/18639 0.111111111111111 1.2132396016403 0.422105783927923 0.785849674901182 GO:0005262 calcium channel activity 13/1707 131/18639 0.099236641221374 1.08358040757188 0.423578071755253 0.78732489099933 GO:0008143 poly(A) binding 3/1707 26/18639 0.115384615384615 1.25990266324185 0.430143517849105 0.794427741099303 GO:0030507 spectrin binding 3/1707 26/18639 0.115384615384615 1.25990266324185 0.430143517849105 0.794427741099303 GO:0070006 metalloaminopeptidase activity 3/1707 26/18639 0.115384615384615 1.25990266324185 0.430143517849105 0.794427741099303 GO:0070412 R-SMAD binding 3/1707 26/18639 0.115384615384615 1.25990266324185 0.430143517849105 0.794427741099303 GO:0005504 fatty acid binding 5/1707 47/18639 0.106382978723404 1.16161238454923 0.433211932318712 0.798626296141717 GO:0033293 monocarboxylic acid binding 8/1707 79/18639 0.10126582278481 1.10573735845699 0.437907585127458 0.798626296141717 GO:0015385 sodium:proton antiporter activity 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:0015562 efflux transmembrane transporter activity 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:0016675 oxidoreductase activity, acting on a heme group of donors 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/1707 16/18639 0.125 1.36489455184534 0.438083030562926 0.798626296141717 GO:1902936 phosphatidylinositol bisphosphate binding 11/1707 111/18639 0.0990990990990991 1.08207856362514 0.438623768865399 0.798626296141717 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/1707 229/18639 0.0960698689956332 1.04900192630908 0.439660464392769 0.79925717074855 GO:0019213 deacetylase activity 4/1707 37/18639 0.108108108108108 1.18044934213651 0.443231791168265 0.804486542590675 GO:0004683 calcium/calmodulin-dependent protein kinase activity 3/1707 27/18639 0.111111111111111 1.2132396016403 0.45506121465824 0.824534923700647 GO:0072341 modified amino acid binding 9/1707 91/18639 0.0989010989010989 1.07991656849302 0.456226128504134 0.824534923700647 GO:0004879 nuclear receptor activity 6/1707 59/18639 0.101694915254237 1.11042268624706 0.457837613073848 0.824534923700647 GO:0036002 pre-mRNA binding 6/1707 59/18639 0.101694915254237 1.11042268624706 0.457837613073848 0.824534923700647 GO:0070888 E-box binding 6/1707 59/18639 0.101694915254237 1.11042268624706 0.457837613073848 0.824534923700647 GO:0008238 exopeptidase activity 10/1707 102/18639 0.0980392156862745 1.07050553085909 0.459670416009266 0.826550220091196 GO:0001618 virus receptor activity 8/1707 81/18639 0.0987654320987654 1.07843520145805 0.466370486383377 0.83229150283619 GO:0004659 prenyltransferase activity 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0005092 GDP-dissociation inhibitor activity 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0030169 low-density lipoprotein particle binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0036041 long-chain fatty acid binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0046965 nuclear retinoid X receptor binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0070402 NADPH binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0070403 NAD+ binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:1990226 histone methyltransferase binding 2/1707 17/18639 0.117647058823529 1.28460663703091 0.469869911464539 0.83229150283619 GO:0035254 glutamate receptor binding 5/1707 49/18639 0.102040816326531 1.11419963415946 0.470050641498159 0.83229150283619 GO:0098531 ligand-modulated transcription factor activity 6/1707 60/18639 0.1 1.09191564147627 0.474377676736563 0.838670762841129 GO:0050698 proteoglycan sulfotransferase activity 3/1707 28/18639 0.107142857142857 1.16990961586744 0.479508511620457 0.846449476305624 GO:0140272 exogenous protein binding 8/1707 82/18639 0.0975609756097561 1.06528355265978 0.480490564540411 0.846892045263007 GO:0001217 DNA-binding transcription repressor activity 26/1707 278/18639 0.0935251798561151 1.02121606756774 0.485556363738031 0.854520165970578 GO:0032813 tumor necrosis factor receptor superfamily binding 5/1707 50/18639 0.1 1.09191564147627 0.488188970595062 0.857849511303615 GO:0016836 hydro-lyase activity 6/1707 61/18639 0.0983606557377049 1.07401538505863 0.490769391399704 0.86107720491039 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/1707 268/18639 0.0932835820895522 1.01857802376518 0.492431719391438 0.862686733820402 GO:0008135 translation factor activity, RNA binding 8/1707 83/18639 0.0963855421686747 1.05244881106147 0.494515083417991 0.865027895163193 GO:0009055 electron transfer activity 11/1707 116/18639 0.0948275862068965 1.0354372462275 0.498369972459931 0.867722025385711 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1707 18/18639 0.111111111111111 1.2132396016403 0.500551220170687 0.867722025385711 GO:0017075 syntaxin-1 binding 2/1707 18/18639 0.111111111111111 1.2132396016403 0.500551220170687 0.867722025385711 GO:0031690 adrenergic receptor binding 2/1707 18/18639 0.111111111111111 1.2132396016403 0.500551220170687 0.867722025385711 GO:0032393 MHC class I receptor activity 2/1707 18/18639 0.111111111111111 1.2132396016403 0.500551220170687 0.867722025385711 GO:0050811 GABA receptor binding 2/1707 18/18639 0.111111111111111 1.2132396016403 0.500551220170687 0.867722025385711 GO:0016417 S-acyltransferase activity 3/1707 29/18639 0.103448275862069 1.12956790497546 0.503425823947587 0.86891203572098 GO:0099604 ligand-gated calcium channel activity 3/1707 29/18639 0.103448275862069 1.12956790497546 0.503425823947587 0.86891203572098 GO:0004177 aminopeptidase activity 4/1707 40/18639 0.1 1.09191564147627 0.504989464628859 0.86891203572098 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1707 40/18639 0.1 1.09191564147627 0.504989464628859 0.86891203572098 GO:0071949 FAD binding 4/1707 40/18639 0.1 1.09191564147627 0.504989464628859 0.86891203572098 GO:0016830 carbon-carbon lyase activity 5/1707 51/18639 0.0980392156862745 1.07050553085909 0.506099397019491 0.869529824552776 GO:0015179 L-amino acid transmembrane transporter activity 6/1707 62/18639 0.0967741935483871 1.05669255626736 0.506989825967626 0.869769212548906 GO:0180051 translation factor activity 8/1707 84/18639 0.0952380952380952 1.03991965854883 0.508428967933787 0.870947847436871 GO:0016407 acetyltransferase activity 9/1707 96/18639 0.09375 1.02367091388401 0.522018595720989 0.892906253832948 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1707 41/18639 0.0975609756097561 1.06528355265978 0.524899292359951 0.896509410844872 GO:0001965 G-protein alpha-subunit binding 3/1707 30/18639 0.1 1.09191564147627 0.526762612977521 0.897045743864661 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/1707 30/18639 0.1 1.09191564147627 0.526762612977521 0.897045743864661 GO:0070003 threonine-type peptidase activity 2/1707 19/18639 0.105263157894737 1.1493848857645 0.530062778358683 0.901340231041636 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1707 86/18639 0.0930232558139535 1.01573548044305 0.535868317450507 0.909876116726815 GO:0051018 protein kinase A binding 5/1707 53/18639 0.0943396226415094 1.03010909573233 0.541129642765527 0.917464313795725 GO:0004518 nuclease activity 19/1707 209/18639 0.0909090909090909 0.992650583160249 0.548843629465016 0.927542405112571 GO:0016411 acylglycerol O-acyltransferase activity 3/1707 31/18639 0.0967741935483871 1.05669255626736 0.549476761577913 0.927542405112571 GO:0047499 calcium-independent phospholipase A2 activity 3/1707 31/18639 0.0967741935483871 1.05669255626736 0.549476761577913 0.927542405112571 GO:0098631 cell adhesion mediator activity 7/1707 76/18639 0.0921052631578947 1.00571177504394 0.551576626946914 0.929731781665978 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/1707 54/18639 0.0925925925925926 1.01103300136692 0.558202076582041 0.935720003288364 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1707 20/18639 0.1 1.09191564147627 0.558361418197115 0.935720003288364 GO:0016408 C-acyltransferase activity 2/1707 20/18639 0.1 1.09191564147627 0.558361418197115 0.935720003288364 GO:0016505 peptidase activator activity involved in apoptotic process 2/1707 20/18639 0.1 1.09191564147627 0.558361418197115 0.935720003288364 GO:0008375 acetylglucosaminyltransferase activity 4/1707 43/18639 0.0930232558139535 1.01573548044305 0.563505128966034 0.942975345870907 GO:0030515 snoRNA binding 3/1707 32/18639 0.09375 1.02367091388401 0.571533939443887 0.95365461365421 GO:0047498 calcium-dependent phospholipase A2 activity 3/1707 32/18639 0.09375 1.02367091388401 0.571533939443887 0.95365461365421 GO:0043022 ribosome binding 10/1707 112/18639 0.0892857142857143 0.974924679889531 0.581657398743272 0.963535414577622 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1707 21/18639 0.0952380952380952 1.03991965854883 0.585421676067669 0.963535414577622 GO:0015174 basic amino acid transmembrane transporter activity 2/1707 21/18639 0.0952380952380952 1.03991965854883 0.585421676067669 0.963535414577622 GO:0036122 BMP binding 2/1707 21/18639 0.0952380952380952 1.03991965854883 0.585421676067669 0.963535414577622 GO:0061891 calcium ion sensor activity 2/1707 21/18639 0.0952380952380952 1.03991965854883 0.585421676067669 0.963535414577622 GO:0070182 DNA polymerase binding 2/1707 21/18639 0.0952380952380952 1.03991965854883 0.585421676067669 0.963535414577622 GO:0030296 protein tyrosine kinase activator activity 3/1707 33/18639 0.0909090909090909 0.992650583160249 0.592906969807002 0.963535414577622 GO:0140416 transcription regulator inhibitor activity 3/1707 33/18639 0.0909090909090909 0.992650583160249 0.592906969807002 0.963535414577622 GO:0019838 growth factor binding 12/1707 136/18639 0.0882352941176471 0.963454977773183 0.597634028314196 0.963535414577622 GO:0030145 manganese ion binding 6/1707 68/18639 0.0882352941176471 0.963454977773183 0.59962719485462 0.963535414577622 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/1707 91/18639 0.0879120879120879 0.959925838660461 0.601623624139024 0.963535414577622 GO:0042277 peptide binding 22/1707 249/18639 0.0883534136546185 0.964744743473013 0.602984526425006 0.963535414577622 GO:0008093 cytoskeletal anchor activity 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0034062 5'-3' RNA polymerase activity 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0061133 endopeptidase activator activity 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0097747 RNA polymerase activity 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0140784 metal ion sensor activity 2/1707 22/18639 0.0909090909090909 0.992650583160249 0.611232915106927 0.963535414577622 GO:0015035 protein-disulfide reductase activity 3/1707 34/18639 0.0882352941176471 0.963454977773183 0.613575206646165 0.963535414577622 GO:0000182 rDNA binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0004090 carbonyl reductase (NADPH) activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0005031 tumor necrosis factor receptor activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0005381 iron ion transmembrane transporter activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0008519 ammonium channel activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0015187 glycine transmembrane transporter activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0015279 store-operated calcium channel activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0015643 toxic substance binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0030957 Tat protein binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0031434 mitogen-activated protein kinase kinase binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0031720 haptoglobin binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0032356 oxidized DNA binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0035256 G protein-coupled glutamate receptor binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0043121 neurotrophin binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0043422 protein kinase B binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0097177 mitochondrial ribosome binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0098505 G-rich strand telomeric DNA binding 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0140940 histone H2A methyltransferase activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:1990259 histone H2AQ104 methyltransferase activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:1990757 ubiquitin ligase activator activity 1/1707 10/18639 0.1 1.09191564147627 0.617394885679271 0.963535414577622 GO:0004623 phospholipase A2 activity 3/1707 35/18639 0.0857142857142857 0.935927692693949 0.633523929448898 0.973490136778794 GO:0003887 DNA-directed DNA polymerase activity 2/1707 23/18639 0.0869565217391304 0.949491862153282 0.635796825823202 0.973490136778794 GO:0004602 glutathione peroxidase activity 2/1707 23/18639 0.0869565217391304 0.949491862153282 0.635796825823202 0.973490136778794 GO:0031681 G-protein beta-subunit binding 2/1707 23/18639 0.0869565217391304 0.949491862153282 0.635796825823202 0.973490136778794 GO:0043274 phospholipase binding 2/1707 23/18639 0.0869565217391304 0.949491862153282 0.635796825823202 0.973490136778794 GO:0015459 potassium channel regulator activity 5/1707 59/18639 0.0847457627118644 0.925352238539215 0.638398355055774 0.973490136778794 GO:0001540 amyloid-beta binding 7/1707 83/18639 0.0843373493975904 0.920892709678785 0.646389225226875 0.973490136778794 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/1707 48/18639 0.0833333333333333 0.909929701230228 0.65188604847522 0.973490136778794 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0001851 complement component C3b binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0003953 NAD+ nucleosidase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0005225 volume-sensitive anion channel activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0008172 S-methyltransferase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0008432 JUN kinase binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0010854 adenylate cyclase regulator activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0019206 nucleoside kinase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0019215 intermediate filament binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0035252 UDP-xylosyltransferase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0042285 xylosyltransferase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0043522 leucine zipper domain binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0045294 alpha-catenin binding 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0140537 transcription regulator activator activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0180030 inositol phosphate kinase activity 1/1707 11/18639 0.0909090909090909 0.992650583160249 0.65245350021282 0.973490136778794 GO:0004190 aspartic-type endopeptidase activity 3/1707 36/18639 0.0833333333333333 0.909929701230228 0.652743760859895 0.973490136778794 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/1707 36/18639 0.0833333333333333 0.909929701230228 0.652743760859895 0.973490136778794 GO:0016757 glycosyltransferase activity 23/1707 267/18639 0.0861423220973783 0.940601488912146 0.653002465580668 0.973490136778794 GO:0042379 chemokine receptor binding 6/1707 72/18639 0.0833333333333333 0.909929701230228 0.65583323728696 0.973490136778794 GO:0005315 phosphate transmembrane transporter activity 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0048027 mRNA 5'-UTR binding 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0050431 transforming growth factor beta binding 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0140612 DNA damage sensor activity 2/1707 24/18639 0.0833333333333333 0.909929701230228 0.659125259733492 0.973490136778794 GO:0004175 endopeptidase activity 35/1707 405/18639 0.0864197530864197 0.943630801275792 0.66745805508926 0.973490136778794 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/1707 61/18639 0.0819672131147541 0.895012820882192 0.667821819956026 0.973490136778794 GO:0060590 ATPase regulator activity 4/1707 49/18639 0.0816326530612245 0.891359707327571 0.668049195762069 0.973490136778794 GO:0030280 structural constituent of skin epidermis 3/1707 37/18639 0.0810810810810811 0.885337006602385 0.671230111126804 0.973490136778794 GO:0070001 aspartic-type peptidase activity 3/1707 37/18639 0.0810810810810811 0.885337006602385 0.671230111126804 0.973490136778794 GO:0000030 mannosyltransferase activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0005537 D-mannose binding 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0008483 transaminase activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0015662 P-type ion transporter activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0019707 protein-cysteine S-acyltransferase activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0140358 P-type transmembrane transporter activity 2/1707 25/18639 0.08 0.873532513181019 0.681238356040005 0.973490136778794 GO:0048020 CCR chemokine receptor binding 4/1707 50/18639 0.08 0.873532513181019 0.683689215341809 0.973490136778794 GO:0004126 cytidine deaminase activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0004859 phospholipase inhibitor activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0005247 voltage-gated chloride channel activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0005436 sodium:phosphate symporter activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0008179 adenylate cyclase binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0008504 monoamine transmembrane transporter activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0010853 cyclase activator activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0015368 calcium:monoatomic cation antiporter activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0016208 AMP binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0016840 carbon-nitrogen lyase activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0036009 protein-glutamine N-methyltransferase activity 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0042301 phosphate ion binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0043047 single-stranded telomeric DNA binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0045295 gamma-catenin binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0097677 STAT family protein binding 1/1707 12/18639 0.0833333333333333 0.909929701230228 0.684301356941225 0.973490136778794 GO:0008194 UDP-glycosyltransferase activity 12/1707 145/18639 0.0827586206896552 0.903654323980365 0.686120429671522 0.974880316024076 GO:0042887 amide transmembrane transporter activity 3/1707 38/18639 0.0789473684210526 0.862038664323374 0.688982652070141 0.976550686777507 GO:0043531 ADP binding 3/1707 38/18639 0.0789473684210526 0.862038664323374 0.688982652070141 0.976550686777507 GO:0005507 copper ion binding 5/1707 63/18639 0.0793650793650794 0.86659971545736 0.695629224775107 0.977423739417389 GO:0015297 antiporter activity 11/1707 135/18639 0.0814814814814815 0.88970904120289 0.701759592930768 0.977423739417389 GO:0015145 monosaccharide transmembrane transporter activity 2/1707 26/18639 0.0769230769230769 0.839935108827903 0.702162925889247 0.977423739417389 GO:0034237 protein kinase A regulatory subunit binding 2/1707 26/18639 0.0769230769230769 0.839935108827903 0.702162925889247 0.977423739417389 GO:0050750 low-density lipoprotein particle receptor binding 2/1707 26/18639 0.0769230769230769 0.839935108827903 0.702162925889247 0.977423739417389 GO:0051139 metal cation:proton antiporter activity 2/1707 26/18639 0.0769230769230769 0.839935108827903 0.702162925889247 0.977423739417389 GO:0097602 cullin family protein binding 2/1707 26/18639 0.0769230769230769 0.839935108827903 0.702162925889247 0.977423739417389 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/1707 39/18639 0.0769230769230769 0.839935108827903 0.706004822330018 0.977423739417389 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0004465 lipoprotein lipase activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0005035 death receptor activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0008253 5'-nucleotidase activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0008417 fucosyltransferase activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0030955 potassium ion binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0039706 co-receptor binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0051011 microtubule minus-end binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0061459 L-arginine transmembrane transporter activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0071837 HMG box domain binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0089720 caspase binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0097157 pre-mRNA intronic binding 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0140666 annealing activity 1/1707 13/18639 0.0769230769230769 0.839935108827903 0.713232348711307 0.977423739417389 GO:0003724 RNA helicase activity 6/1707 77/18639 0.0779220779220779 0.850843356994499 0.718807473065482 0.98389959079176 GO:0160215 deacylase activity 5/1707 65/18639 0.0769230769230769 0.839935108827903 0.721792014564495 0.984032113520056 GO:0001671 ATPase activator activity 2/1707 27/18639 0.0740740740740741 0.808826401093536 0.721931062787728 0.984032113520056 GO:0004364 glutathione transferase activity 2/1707 27/18639 0.0740740740740741 0.808826401093536 0.721931062787728 0.984032113520056 GO:0015036 disulfide oxidoreductase activity 3/1707 40/18639 0.075 0.818936731107206 0.722303364846328 0.984032113520056 GO:0005544 calcium-dependent phospholipid binding 4/1707 53/18639 0.0754716981132075 0.824087276585867 0.727452751933897 0.988270725736406 GO:0001530 lipopolysaccharide binding 3/1707 41/18639 0.0731707317073171 0.798962664494835 0.737887896884726 0.988270725736406 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1707 41/18639 0.0731707317073171 0.798962664494835 0.737887896884726 0.988270725736406 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1707 41/18639 0.0731707317073171 0.798962664494835 0.737887896884726 0.988270725736406 GO:0004065 arylsulfatase activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0005313 L-glutamate transmembrane transporter activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0005344 oxygen carrier activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0008191 metalloendopeptidase inhibitor activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0008559 ABC-type xenobiotic transporter activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0016530 metallochaperone activity 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0031404 chloride ion binding 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0098847 sequence-specific single stranded DNA binding 1/1707 14/18639 0.0714285714285714 0.779939743911624 0.739513481576646 0.988270725736406 GO:0045499 chemorepellent activity 2/1707 28/18639 0.0714285714285714 0.779939743911624 0.740578951339056 0.988270725736406 GO:0051119 sugar transmembrane transporter activity 2/1707 28/18639 0.0714285714285714 0.779939743911624 0.740578951339056 0.988270725736406 GO:0051537 2 iron, 2 sulfur cluster binding 2/1707 28/18639 0.0714285714285714 0.779939743911624 0.740578951339056 0.988270725736406 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/1707 54/18639 0.0740740740740741 0.808826401093536 0.740992805962046 0.988270725736406 GO:0050661 NADP binding 4/1707 54/18639 0.0740740740740741 0.808826401093536 0.740992805962046 0.988270725736406 GO:0051287 NAD binding 4/1707 54/18639 0.0740740740740741 0.808826401093536 0.740992805962046 0.988270725736406 GO:0008186 ATP-dependent activity, acting on RNA 6/1707 79/18639 0.0759493670886076 0.82930301884274 0.741629758778011 0.988270725736406 GO:0008173 RNA methyltransferase activity 5/1707 67/18639 0.0746268656716418 0.814862419012145 0.746304507718222 0.992146500420236 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/1707 67/18639 0.0746268656716418 0.814862419012145 0.746304507718222 0.992146500420236 GO:0052689 carboxylic ester hydrolase activity 7/1707 92/18639 0.0760869565217391 0.830805379384122 0.749133975333755 0.992146500420236 GO:0051879 Hsp90 protein binding 3/1707 42/18639 0.0714285714285714 0.779939743911624 0.752770512405177 0.992146500420236 GO:0008374 O-acyltransferase activity 4/1707 55/18639 0.0727272727272727 0.794120466528199 0.754015634169036 0.992146500420236 GO:0004181 metallocarboxypeptidase activity 2/1707 29/18639 0.0689655172413793 0.753045269983637 0.75814584966435 0.992146500420236 GO:0004629 phospholipase C activity 2/1707 29/18639 0.0689655172413793 0.753045269983637 0.75814584966435 0.992146500420236 GO:0035250 UDP-galactosyltransferase activity 2/1707 29/18639 0.0689655172413793 0.753045269983637 0.75814584966435 0.992146500420236 GO:0106222 lncRNA binding 2/1707 29/18639 0.0689655172413793 0.753045269983637 0.75814584966435 0.992146500420236 GO:0022804 active transmembrane transporter activity 38/1707 457/18639 0.0831509846827133 0.907938607792088 0.759389490367281 0.992146500420236 GO:0015101 organic cation transmembrane transporter activity 6/1707 81/18639 0.0740740740740741 0.808826401093536 0.763091658638824 0.992146500420236 GO:0004089 carbonate dehydratase activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0005041 low-density lipoprotein particle receptor activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0016846 carbon-sulfur lyase activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0033130 acetylcholine receptor binding 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0034483 heparan sulfate sulfotransferase activity 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0050700 CARD domain binding 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0050780 dopamine receptor binding 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0051371 muscle alpha-actinin binding 1/1707 15/18639 0.0666666666666667 0.727943760984183 0.763387333224896 0.992146500420236 GO:0061134 peptidase regulator activity 18/1707 226/18639 0.079646017699115 0.869667325069599 0.766696940055317 0.995330780923831 GO:0016769 transferase activity, transferring nitrogenous groups 2/1707 30/18639 0.0666666666666667 0.727943760984183 0.77467322371341 0.996660333156692 GO:0048019 receptor antagonist activity 2/1707 30/18639 0.0666666666666667 0.727943760984183 0.77467322371341 0.996660333156692 GO:0005126 cytokine receptor binding 22/1707 275/18639 0.08 0.873532513181019 0.777917965264425 0.996660333156692 GO:0004601 peroxidase activity 4/1707 57/18639 0.0701754385964912 0.766256590509666 0.778536145379421 0.996660333156692 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/1707 57/18639 0.0701754385964912 0.766256590509666 0.778536145379421 0.996660333156692 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1707 70/18639 0.0714285714285714 0.779939743911624 0.780013974935142 0.996660333156692 GO:0016790 thiolester hydrolase activity 3/1707 44/18639 0.0681818181818182 0.744487937370187 0.780488588618242 0.996660333156692 GO:0003688 DNA replication origin binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0005149 interleukin-1 receptor binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0005159 insulin-like growth factor receptor binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0008142 oxysterol binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0015378 sodium:chloride symporter activity 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0017070 U6 snRNA binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0019841 retinol binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0022858 alanine transmembrane transporter activity 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0055102 lipase inhibitor activity 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0070411 I-SMAD binding 1/1707 16/18639 0.0625 0.682447275922671 0.785074286735694 0.996660333156692 GO:0004896 cytokine receptor activity 7/1707 96/18639 0.0729166666666667 0.79618848857645 0.787307733072978 0.996660333156692 GO:0016878 acid-thiol ligase activity 2/1707 31/18639 0.0645161290322581 0.704461704178241 0.790204014205513 0.996660333156692 GO:0070325 lipoprotein particle receptor binding 2/1707 31/18639 0.0645161290322581 0.704461704178241 0.790204014205513 0.996660333156692 GO:0072349 modified amino acid transmembrane transporter activity 2/1707 31/18639 0.0645161290322581 0.704461704178241 0.790204014205513 0.996660333156692 GO:0140299 molecular sensor activity 5/1707 71/18639 0.0704225352112676 0.768954677095968 0.790450748058167 0.996660333156692 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 4/1707 59/18639 0.0677966101694915 0.740281790831372 0.801079410048084 0.996660333156692 GO:0030246 carbohydrate binding 22/1707 280/18639 0.0785714285714286 0.857933718302787 0.804657096092757 0.996660333156692 GO:0042626 ATPase-coupled transmembrane transporter activity 7/1707 98/18639 0.0714285714285714 0.779939743911624 0.804684743553258 0.996660333156692 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0008484 sulfuric ester hydrolase activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0009881 photoreceptor activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0016018 cyclosporin A binding 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0016805 dipeptidase activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0019198 transmembrane receptor protein phosphatase activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0032977 membrane insertase activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0045125 bioactive lipid receptor activity 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0045236 CXCR chemokine receptor binding 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0070492 oligosaccharide binding 1/1707 17/18639 0.0588235294117647 0.642303318515455 0.804774560190142 0.996660333156692 GO:0008378 galactosyltransferase activity 2/1707 32/18639 0.0625 0.682447275922671 0.804782019189621 0.996660333156692 GO:0071813 lipoprotein particle binding 2/1707 32/18639 0.0625 0.682447275922671 0.804782019189621 0.996660333156692 GO:0071814 protein-lipid complex binding 2/1707 32/18639 0.0625 0.682447275922671 0.804782019189621 0.996660333156692 GO:0004180 carboxypeptidase activity 3/1707 46/18639 0.0652173913043478 0.712118896614961 0.805590735608518 0.996660333156692 GO:0004521 RNA endonuclease activity 5/1707 73/18639 0.0684931506849315 0.747887425668681 0.810158784588263 0.999999999991504 GO:0005178 integrin binding 12/1707 161/18639 0.0745341614906832 0.813850167559956 0.811566191898433 0.999999999991504 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1707 60/18639 0.0666666666666667 0.727943760984183 0.811634416064942 0.999999999991504 GO:0042923 neuropeptide binding 2/1707 33/18639 0.0606060606060606 0.661767055440166 0.818451377214306 0.999999999991504 GO:0031406 carboxylic acid binding 14/1707 187/18639 0.0748663101604278 0.817476950837852 0.821200131917088 0.999999999991504 GO:0003746 translation elongation factor activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0008308 voltage-gated monoatomic anion channel activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0015172 acidic amino acid transmembrane transporter activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0015373 monoatomic anion:sodium symporter activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0016854 racemase and epimerase activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0017128 phospholipid scramblase activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0030228 lipoprotein particle receptor activity 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0034185 apolipoprotein binding 1/1707 18/18639 0.0555555555555556 0.606619800820152 0.822670050779521 0.999999999991504 GO:0015020 glucuronosyltransferase activity 2/1707 34/18639 0.0588235294117647 0.642303318515455 0.831256137874815 0.999999999991504 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1707 34/18639 0.0588235294117647 0.642303318515455 0.831256137874815 0.999999999991504 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1707 34/18639 0.0588235294117647 0.642303318515455 0.831256137874815 0.999999999991504 GO:0051427 hormone receptor binding 2/1707 34/18639 0.0588235294117647 0.642303318515455 0.831256137874815 0.999999999991504 GO:0043177 organic acid binding 14/1707 189/18639 0.0740740740740741 0.808826401093536 0.832615254179975 0.999999999991504 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0008301 DNA binding, bending 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0008381 mechanosensitive monoatomic ion channel activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0008574 plus-end-directed microtubule motor activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0015245 fatty acid transmembrane transporter activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0016918 retinal binding 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0031420 alkali metal ion binding 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0034987 immunoglobulin receptor binding 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0097001 ceramide binding 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:0141147 intracellularly calcium-gated channel activity 1/1707 19/18639 0.0526315789473684 0.57469244288225 0.838926010358457 0.999999999991504 GO:1901682 sulfur compound transmembrane transporter activity 4/1707 63/18639 0.0634920634920635 0.693279772365888 0.840570282385579 0.999999999991504 GO:0005343 organic acid:sodium symporter activity 2/1707 35/18639 0.0571428571428571 0.623951795129299 0.843239908082446 0.999999999991504 GO:0034061 DNA polymerase activity 2/1707 35/18639 0.0571428571428571 0.623951795129299 0.843239908082446 0.999999999991504 GO:0043015 gamma-tubulin binding 2/1707 35/18639 0.0571428571428571 0.623951795129299 0.843239908082446 0.999999999991504 GO:0015605 organophosphate ester transmembrane transporter activity 3/1707 50/18639 0.06 0.655149384885764 0.848568704543365 0.999999999991504 GO:0016798 hydrolase activity, acting on glycosyl bonds 9/1707 130/18639 0.0692307692307692 0.755941597945113 0.852114136047351 0.999999999991504 GO:0001614 purinergic nucleotide receptor activity 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0001972 retinoic acid binding 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0010851 cyclase regulator activity 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0016502 nucleotide receptor activity 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0031418 L-ascorbic acid binding 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0140664 ATP-dependent DNA damage sensor activity 1/1707 20/18639 0.05 0.545957820738137 0.853692567840633 0.999999999991504 GO:0140375 immune receptor activity 11/1707 156/18639 0.0705128205128205 0.769940516425578 0.856019635372761 0.999999999991504 GO:0019843 rRNA binding 4/1707 65/18639 0.0615384615384615 0.671948087062323 0.857711436751967 0.999999999991504 GO:0008236 serine-type peptidase activity 14/1707 194/18639 0.0721649484536082 0.787980359828239 0.858743439042075 0.999999999991504 GO:0015370 solute:sodium symporter activity 5/1707 79/18639 0.0632911392405063 0.691085849035617 0.860497034243825 0.999999999991504 GO:0042805 actinin binding 2/1707 37/18639 0.0540540540540541 0.590224671068256 0.864915018239969 0.999999999991504 GO:0001846 opsonin binding 1/1707 21/18639 0.0476190476190476 0.519959829274416 0.867106112429281 0.999999999991504 GO:0005123 death receptor binding 1/1707 21/18639 0.0476190476190476 0.519959829274416 0.867106112429281 0.999999999991504 GO:0015125 bile acid transmembrane transporter activity 1/1707 21/18639 0.0476190476190476 0.519959829274416 0.867106112429281 0.999999999991504 GO:0051428 peptide hormone receptor binding 1/1707 21/18639 0.0476190476190476 0.519959829274416 0.867106112429281 0.999999999991504 GO:1904047 S-adenosyl-L-methionine binding 1/1707 21/18639 0.0476190476190476 0.519959829274416 0.867106112429281 0.999999999991504 GO:0015293 symporter activity 10/1707 146/18639 0.0684931506849315 0.747887425668681 0.870427477021848 0.999999999991504 GO:0008237 metallopeptidase activity 13/1707 184/18639 0.0706521739130435 0.771462137999541 0.870612510661154 0.999999999991504 GO:0016758 hexosyltransferase activity 14/1707 197/18639 0.0710659898477157 0.775980658917149 0.872828778480446 0.999999999991504 GO:0005501 retinoid binding 2/1707 38/18639 0.0526315789473684 0.57469244288225 0.874689038582737 0.999999999991504 GO:0019840 isoprenoid binding 2/1707 38/18639 0.0526315789473684 0.57469244288225 0.874689038582737 0.999999999991504 GO:0008146 sulfotransferase activity 3/1707 53/18639 0.0566037735849057 0.6180654574394 0.87513787175031 0.999999999991504 GO:0016860 intramolecular oxidoreductase activity 3/1707 53/18639 0.0566037735849057 0.6180654574394 0.87513787175031 0.999999999991504 GO:0017171 serine hydrolase activity 14/1707 198/18639 0.0707070707070707 0.772061564680194 0.877269032793387 0.999999999991504 GO:0008649 rRNA methyltransferase activity 1/1707 22/18639 0.0454545454545455 0.496325291580125 0.879290550397012 0.999999999991504 GO:0015377 chloride:monoatomic cation symporter activity 1/1707 22/18639 0.0454545454545455 0.496325291580125 0.879290550397012 0.999999999991504 GO:0033691 sialic acid binding 1/1707 22/18639 0.0454545454545455 0.496325291580125 0.879290550397012 0.999999999991504 GO:0004620 phospholipase activity 7/1707 109/18639 0.0642201834862385 0.701230228471002 0.881361452288268 0.999999999991504 GO:0015291 secondary active transmembrane transporter activity 21/1707 287/18639 0.0731707317073171 0.798962664494835 0.886297087293996 0.999999999991504 GO:0019842 vitamin binding 10/1707 150/18639 0.0666666666666667 0.727943760984183 0.890091925826005 0.999999999991504 GO:0005283 amino acid:sodium symporter activity 1/1707 23/18639 0.0434782608695652 0.474745931076641 0.890358446968549 0.999999999991504 GO:0016493 C-C chemokine receptor activity 1/1707 23/18639 0.0434782608695652 0.474745931076641 0.890358446968549 0.999999999991504 GO:0016849 phosphorus-oxygen lyase activity 1/1707 23/18639 0.0434782608695652 0.474745931076641 0.890358446968549 0.999999999991504 GO:0140102 catalytic activity, acting on a rRNA 1/1707 23/18639 0.0434782608695652 0.474745931076641 0.890358446968549 0.999999999991504 GO:0004252 serine-type endopeptidase activity 12/1707 176/18639 0.0681818181818182 0.744487937370187 0.891397574426669 0.999999999991504 GO:0015144 carbohydrate transmembrane transporter activity 2/1707 40/18639 0.05 0.545957820738137 0.892307301140854 0.999999999991504 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/1707 40/18639 0.05 0.545957820738137 0.892307301140854 0.999999999991504 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1707 70/18639 0.0571428571428571 0.623951795129299 0.89381341129536 0.999999999991504 GO:0170055 lipid transmembrane transporter activity 3/1707 56/18639 0.0535714285714286 0.584954807933718 0.897487536662766 0.999999999991504 GO:0004622 lysophospholipase activity 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0004806 triacylglycerol lipase activity 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0005540 hyaluronic acid binding 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0015149 hexose transmembrane transporter activity 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0015295 solute:proton symporter activity 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0019957 C-C chemokine binding 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0030215 semaphorin receptor binding 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0055056 D-glucose transmembrane transporter activity 1/1707 24/18639 0.0416666666666667 0.454964850615114 0.900412063804856 0.999999999991504 GO:0050660 flavin adenine dinucleotide binding 5/1707 86/18639 0.0581395348837209 0.634834675276904 0.904581891525344 0.999999999991504 GO:0042056 chemoattractant activity 2/1707 42/18639 0.0476190476190476 0.519959829274416 0.907599031576045 0.999999999991504 GO:0001848 complement binding 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0005251 delayed rectifier potassium channel activity 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0015271 outward rectifier potassium channel activity 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0047617 fatty acyl-CoA hydrolase activity 1/1707 25/18639 0.04 0.43676625659051 0.909544301628391 0.999999999991504 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 12/1707 181/18639 0.0662983425414365 0.723921972249463 0.910901488997047 0.999999999991504 GO:0005245 voltage-gated calcium channel activity 2/1707 43/18639 0.0465116279069767 0.507867740221523 0.914459207937651 0.999999999991504 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1707 43/18639 0.0465116279069767 0.507867740221523 0.914459207937651 0.999999999991504 GO:0030414 peptidase inhibitor activity 11/1707 169/18639 0.0650887573964497 0.71071432285438 0.914483077385273 0.999999999991504 GO:0015171 amino acid transmembrane transporter activity 6/1707 102/18639 0.0588235294117647 0.642303318515455 0.914619702399122 0.999999999991504 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/1707 130/18639 0.0615384615384615 0.671948087062323 0.917410820076678 0.999999999991504 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0004435 phosphatidylinositol phospholipase C activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0004950 chemokine receptor activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0005227 calcium-activated cation channel activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0008198 ferrous iron binding 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0015216 purine nucleotide transmembrane transporter activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0016289 acyl-CoA hydrolase activity 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0030247 polysaccharide binding 1/1707 26/18639 0.0384615384615385 0.419967554413952 0.917839556657956 0.999999999991504 GO:0030547 signaling receptor inhibitor activity 2/1707 44/18639 0.0454545454545455 0.496325291580125 0.920838761238576 0.999999999991504 GO:0031072 heat shock protein binding 8/1707 131/18639 0.0610687022900763 0.666818712351923 0.921267918850538 0.999999999991504 GO:0044183 protein folding chaperone 4/1707 75/18639 0.0533333333333333 0.582355008787346 0.921610099127079 0.999999999991504 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 36/1707 484/18639 0.0743801652892562 0.812168658949295 0.924003477806051 0.999999999991504 GO:0005104 fibroblast growth factor receptor binding 1/1707 27/18639 0.037037037037037 0.404413200546768 0.925374498729889 0.999999999991504 GO:0005385 zinc ion transmembrane transporter activity 1/1707 27/18639 0.037037037037037 0.404413200546768 0.925374498729889 0.999999999991504 GO:0023026 MHC class II protein complex binding 1/1707 27/18639 0.037037037037037 0.404413200546768 0.925374498729889 0.999999999991504 GO:0035255 ionotropic glutamate receptor binding 1/1707 27/18639 0.037037037037037 0.404413200546768 0.925374498729889 0.999999999991504 GO:0046915 transition metal ion transmembrane transporter activity 2/1707 45/18639 0.0444444444444444 0.485295840656122 0.926768123133952 0.999999999991504 GO:0051087 protein-folding chaperone binding 8/1707 134/18639 0.0597014925373134 0.651889935209716 0.931920424107651 0.999999999991504 GO:0046625 sphingolipid binding 1/1707 28/18639 0.0357142857142857 0.389969871955812 0.932218778262882 0.999999999991504 GO:0051393 alpha-actinin binding 1/1707 28/18639 0.0357142857142857 0.389969871955812 0.932218778262882 0.999999999991504 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/1707 46/18639 0.0434782608695652 0.474745931076641 0.93227618620329 0.999999999991504 GO:0046943 carboxylic acid transmembrane transporter activity 12/1707 188/18639 0.0638297872340425 0.696967430729537 0.933217867645173 0.999999999991504 GO:0051082 unfolded protein binding 7/1707 121/18639 0.0578512396694215 0.63168673473834 0.934583599159342 0.999999999991504 GO:0019199 transmembrane receptor protein kinase activity 4/1707 78/18639 0.0512820512820513 0.559956739218602 0.93496965254967 0.999999999991504 GO:0005342 organic acid transmembrane transporter activity 12/1707 189/18639 0.0634920634920635 0.693279772365888 0.935978451676355 0.999999999991504 GO:0001216 DNA-binding transcription activator activity 36/1707 491/18639 0.0733197556008147 0.800589879697472 0.937043021422553 0.999999999991504 GO:0140359 ABC-type transporter activity 2/1707 47/18639 0.0425531914893617 0.464644953819691 0.937390330450276 0.999999999991504 GO:0005416 amino acid:monoatomic cation symporter activity 1/1707 29/18639 0.0344827586206897 0.376522634991819 0.938435668569973 0.999999999991504 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1707 30/18639 0.0333333333333333 0.363971880492091 0.944082649427096 0.999999999991504 GO:0015215 nucleotide transmembrane transporter activity 1/1707 30/18639 0.0333333333333333 0.363971880492091 0.944082649427096 0.999999999991504 GO:0022839 monoatomic ion-gated channel activity 1/1707 30/18639 0.0333333333333333 0.363971880492091 0.944082649427096 0.999999999991504 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/1707 30/18639 0.0333333333333333 0.363971880492091 0.944082649427096 0.999999999991504 GO:0038024 cargo receptor activity 3/1707 65/18639 0.0461538461538462 0.503961065296742 0.944531691625693 0.999999999991504 GO:0033218 amide binding 16/1707 247/18639 0.0647773279352227 0.707313775855076 0.948995100546571 0.999999999991504 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1707 31/18639 0.032258064516129 0.352230852089121 0.949211937267815 0.999999999991504 GO:0005452 solute:inorganic anion antiporter activity 1/1707 31/18639 0.032258064516129 0.352230852089121 0.949211937267815 0.999999999991504 GO:0004519 endonuclease activity 7/1707 127/18639 0.0551181102362205 0.601843266955427 0.952278504707816 0.999999999991504 GO:0003730 mRNA 3'-UTR binding 17/1707 262/18639 0.0648854961832061 0.708494881873918 0.952791404560581 0.999999999991504 GO:0015106 bicarbonate transmembrane transporter activity 1/1707 32/18639 0.03125 0.341223637961336 0.953870966883241 0.999999999991504 GO:0042910 xenobiotic transmembrane transporter activity 1/1707 32/18639 0.03125 0.341223637961336 0.953870966883241 0.999999999991504 GO:0030544 Hsp70 protein binding 2/1707 51/18639 0.0392156862745098 0.428202212343637 0.95440448070276 0.999999999991504 GO:0003777 microtubule motor activity 3/1707 68/18639 0.0441176470588235 0.481727488886592 0.955096463552051 0.999999999991504 GO:0061135 endopeptidase regulator activity 11/1707 184/18639 0.0597826086956522 0.652775655230381 0.955765097540443 0.999999999991504 GO:0019239 deaminase activity 1/1707 33/18639 0.0303030303030303 0.330883527720083 0.958102829060395 0.999999999991504 GO:0016298 lipase activity 7/1707 130/18639 0.0538461538461538 0.587954576179532 0.959405550197499 0.999999999991504 GO:0015294 solute:monoatomic cation symporter activity 6/1707 116/18639 0.0517241379310345 0.564783952487728 0.960582417101692 0.999999999991504 GO:0016209 antioxidant activity 4/1707 86/18639 0.0465116279069767 0.507867740221523 0.961098714952873 0.999999999991504 GO:0017046 peptide hormone binding 2/1707 53/18639 0.0377358490566038 0.412043638292934 0.961155473707898 0.999999999991504 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1707 53/18639 0.0377358490566038 0.412043638292934 0.961155473707898 0.999999999991504 GO:0008175 tRNA methyltransferase activity 1/1707 34/18639 0.0294117647058824 0.321151659257728 0.961946668187231 0.999999999991504 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1707 34/18639 0.0294117647058824 0.321151659257728 0.961946668187231 0.999999999991504 GO:0016831 carboxy-lyase activity 1/1707 34/18639 0.0294117647058824 0.321151659257728 0.961946668187231 0.999999999991504 GO:0019825 oxygen binding 1/1707 34/18639 0.0294117647058824 0.321151659257728 0.961946668187231 0.999999999991504 GO:0090482 vitamin transmembrane transporter activity 1/1707 34/18639 0.0294117647058824 0.321151659257728 0.961946668187231 0.999999999991504 GO:0004866 endopeptidase inhibitor activity 9/1707 161/18639 0.0559006211180124 0.610387625669967 0.964562228248684 0.999999999991504 GO:0004033 aldo-keto reductase (NADPH) activity 1/1707 36/18639 0.0277777777777778 0.303309900410076 0.968609257189659 0.999999999991504 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/1707 36/18639 0.0277777777777778 0.303309900410076 0.968609257189659 0.999999999991504 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/1707 36/18639 0.0277777777777778 0.303309900410076 0.968609257189659 0.999999999991504 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/1707 36/18639 0.0277777777777778 0.303309900410076 0.968609257189659 0.999999999991504 GO:0030170 pyridoxal phosphate binding 2/1707 56/18639 0.0357142857142857 0.389969871955812 0.969513398644466 0.999999999991504 GO:0048029 monosaccharide binding 3/1707 74/18639 0.0405405405405405 0.442668503301192 0.970821343819152 0.999999999991504 GO:0022829 wide pore channel activity 1/1707 37/18639 0.027027027027027 0.295112335534128 0.971489652716039 0.999999999991504 GO:0043394 proteoglycan binding 1/1707 37/18639 0.027027027027027 0.295112335534128 0.971489652716039 0.999999999991504 GO:0070279 vitamin B6 binding 2/1707 57/18639 0.0350877192982456 0.383128295254833 0.97189221505737 0.999999999991504 GO:0005109 frizzled binding 1/1707 38/18639 0.0263157894736842 0.287346221441125 0.974105885530453 0.999999999991504 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/1707 39/18639 0.0256410256410256 0.279978369609301 0.976482169246356 0.999999999991504 GO:0140662 ATP-dependent protein folding chaperone 1/1707 40/18639 0.025 0.272978910369069 0.978640499197779 0.999999999991504 GO:0004520 DNA endonuclease activity 1/1707 42/18639 0.0238095238095238 0.259979914637208 0.982381387846147 0.999999999991504 GO:0008307 structural constituent of muscle 1/1707 42/18639 0.0238095238095238 0.259979914637208 0.982381387846147 0.999999999991504 GO:0016859 cis-trans isomerase activity 1/1707 42/18639 0.0238095238095238 0.259979914637208 0.982381387846147 0.999999999991504 GO:0015081 sodium ion transmembrane transporter activity 8/1707 164/18639 0.0487804878048781 0.53264177632989 0.98614014555187 0.999999999991504 GO:0008009 chemokine activity 1/1707 45/18639 0.0222222222222222 0.242647920328061 0.986801490491086 0.999999999991504 GO:0042605 peptide antigen binding 1/1707 45/18639 0.0222222222222222 0.242647920328061 0.986801490491086 0.999999999991504 GO:0008514 organic anion transmembrane transporter activity 15/1707 269/18639 0.0557620817843866 0.60887489301651 0.988943482121518 0.999999999991504 GO:0099095 ligand-gated monoatomic anion channel activity 1/1707 47/18639 0.0212765957446809 0.232322476909846 0.989113660299473 0.999999999991504 GO:0008188 neuropeptide receptor activity 1/1707 48/18639 0.0208333333333333 0.227482425307557 0.990113175245084 0.999999999991504 GO:0038187 pattern recognition receptor activity 1/1707 48/18639 0.0208333333333333 0.227482425307557 0.990113175245084 0.999999999991504 GO:0005261 monoatomic cation channel activity 20/1707 341/18639 0.0586510263929619 0.640419731071129 0.990445902631959 0.999999999991504 GO:1901681 sulfur compound binding 15/1707 275/18639 0.0545454545454545 0.59559034989615 0.991680444581837 0.999999999991504 GO:0004222 metalloendopeptidase activity 4/1707 110/18639 0.0363636363636364 0.3970602332641 0.992539447452668 0.999999999991504 GO:0005010 insulin-like growth factor receptor activity 1/1707 51/18639 0.0196078431372549 0.214101106171818 0.992594275904367 0.999999999991504 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1707 52/18639 0.0192307692307692 0.209983777206976 0.993274369030644 0.999999999991504 GO:0042562 hormone binding 3/1707 94/18639 0.0319148936170213 0.348483715364768 0.993510759079976 0.999999999991504 GO:0004867 serine-type endopeptidase inhibitor activity 3/1707 95/18639 0.0315789473684211 0.34481546572935 0.993994018101717 0.999999999991504 GO:0001664 G protein-coupled receptor binding 16/1707 297/18639 0.0538720538720539 0.588237382613481 0.994304252119123 0.999999999991504 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 5/1707 132/18639 0.0378787878787879 0.413604409650104 0.99471173943751 0.999999999991504 GO:0015103 inorganic anion transmembrane transporter activity 7/1707 165/18639 0.0424242424242424 0.463236938808116 0.994803595589241 0.999999999991504 GO:0046906 tetrapyrrole binding 6/1707 152/18639 0.0394736842105263 0.431019332161687 0.995769892292594 0.999999999991504 GO:0005506 iron ion binding 6/1707 154/18639 0.038961038961039 0.42542167849725 0.996293919251696 0.999999999991504 GO:0005253 monoatomic anion channel activity 3/1707 103/18639 0.029126213592233 0.318033681983381 0.996786706114724 0.999999999991504 GO:0005254 chloride channel activity 2/1707 83/18639 0.0240963855421687 0.263112202765367 0.996814300682132 0.999999999991504 GO:0008528 G protein-coupled peptide receptor activity 4/1707 122/18639 0.0327868852459016 0.358005128352877 0.996886497392725 0.999999999991504 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/1707 60/18639 0.0166666666666667 0.181985940246046 0.996888484258202 0.999999999991504 GO:0004497 monooxygenase activity 3/1707 106/18639 0.0283018867924528 0.3090327287197 0.99746539951618 0.999999999991504 GO:0004536 DNA nuclease activity 1/1707 64/18639 0.015625 0.170611818980668 0.99788390705767 0.999999999991504 GO:0001653 peptide receptor activity 4/1707 128/18639 0.03125 0.341223637961336 0.998007973257363 0.999999999991504 GO:0016853 isomerase activity 7/1707 180/18639 0.0388888888888889 0.424633860574107 0.998008923970371 0.999999999991504 GO:0046873 metal ion transmembrane transporter activity 25/1707 450/18639 0.0555555555555556 0.606619800820152 0.998372254335736 0.999999999991504 GO:0008509 monoatomic anion transmembrane transporter activity 5/1707 149/18639 0.0335570469798658 0.366414644790696 0.998394765873645 0.999999999991504 GO:0099094 ligand-gated monoatomic cation channel activity 4/1707 136/18639 0.0294117647058824 0.321151659257728 0.998911472119927 0.999999999991504 GO:0005249 voltage-gated potassium channel activity 2/1707 98/18639 0.0204081632653061 0.222839926831893 0.999129681766574 0.999999999991504 GO:0015108 chloride transmembrane transporter activity 3/1707 121/18639 0.0247933884297521 0.270722886316432 0.999240857633664 0.999999999991504 GO:0015079 potassium ion transmembrane transporter activity 5/1707 160/18639 0.03125 0.341223637961336 0.999276332474062 0.999999999991504 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1707 122/18639 0.0245901639344262 0.268503846264658 0.999300211253183 0.999999999991504 GO:0020037 heme binding 4/1707 142/18639 0.028169014084507 0.307581870838387 0.9993123725305 0.999999999991504 GO:0022843 voltage-gated monoatomic cation channel activity 4/1707 143/18639 0.027972027972028 0.305430948664692 0.999363352888317 0.999999999991504 GO:0008083 growth factor activity 5/1707 162/18639 0.0308641975308642 0.33701100045564 0.999375105528871 0.999999999991504 GO:0005216 monoatomic ion channel activity 23/1707 448/18639 0.0513392857142857 0.56058169093648 0.999524290318212 0.999999999991504 GO:0005201 extracellular matrix structural constituent 5/1707 168/18639 0.0297619047619048 0.32497489329651 0.9995989564303 0.999999999991504 GO:0005179 hormone activity 3/1707 132/18639 0.0227272727272727 0.248162645790062 0.999691912418665 0.999999999991504 GO:0005244 voltage-gated monoatomic ion channel activity 5/1707 173/18639 0.0289017341040462 0.315582555339964 0.999723861593947 0.999999999991504 GO:0022832 voltage-gated channel activity 5/1707 175/18639 0.0285714285714286 0.31197589756465 0.99976235799308 0.999999999991504 GO:0005539 glycosaminoglycan binding 8/1707 242/18639 0.0330578512396694 0.360963848421909 0.999903430373813 0.999999999991504 GO:0005267 potassium channel activity 2/1707 124/18639 0.0161290322580645 0.17611542604456 0.999912355594144 0.999999999991504 GO:0008201 heparin binding 4/1707 172/18639 0.0232558139534884 0.253933870110761 0.99993523227287 0.999999999991504 GO:0003823 antigen binding 4/1707 174/18639 0.0229885057471264 0.251015089994546 0.999944856748012 0.999999999991504 GO:0015276 ligand-gated monoatomic ion channel activity 4/1707 186/18639 0.021505376344086 0.234820568059414 0.999979155130768 0.999999999991504 GO:0022834 ligand-gated channel activity 4/1707 188/18639 0.0212765957446809 0.232322476909846 0.999982296377236 0.999999999991504 GO:0005125 cytokine activity 5/1707 234/18639 0.0213675213675214 0.233315308007751 0.99999764024827 0.999999999991504 GO:0022836 gated channel activity 9/1707 318/18639 0.0283018867924528 0.3090327287197 0.999998427690873 0.999999999991504 GO:0045182 translation regulator activity 4/1707 356/18639 0.0112359550561798 0.122687150727671 0.999999999991182 0.999999999991504 GO:0030371 translation repressor activity 3/1707 329/18639 0.00911854103343465 0.0995667758185052 0.999999999991504 0.999999999991504