category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	71/1475	203/9376	2.2232478917926	EMP1/THBS1/LAMB3/CAPN2/ITGB6/CAV2/CCND1/FLNB/FLNA/EMP2/MYLK/PPP1CB/CAV1/RAP1A/COL4A5/CCND2/DIAPH1/LAMA3/ITGB4/ACTB/ITGA2/FYN/THBS3/VEGFB/ITGAV/COL1A2/ARHGAP5/LAMC2/PTK2/ARHGAP35/COL4A6/SRC/LAMB2/RASGRF1/ACTG1/RHOA/VCL/VEGFA/ITGB5/ERBB2/ITGA6/PDGFD/ROCK1/ITGB1/MET/MAPK1/SHC3/DOCK1/SOS1/SOS2/LAMC1/MAPK8/PRKCA/PIK3CA/GSK3B/BAD/PIK3R1/IGF1R/MYL12B/PIP5K1A/COL9A3/PPP1R12B/MYL5/COL1A1/BRAF/RAC1/TNC/COL6A1/TLN2/MYL12A/EGF	7.61285250431044
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	72/1475	233/9376	1.96427438713901	THBS1/MYH14/VIM/PDLIM4/COL3A1/ITGB6/TMOD3/PLEC/SPTBN1/JUP/SUN1/NEBL/DCN/DAAM1/LMNA/FBN1/NID2/COL4A5/PDLIM5/DIAPH1/DSG2/COL5A1/SDC1/DSC2/ITGB4/ACTB/ITGA2/ANK2/THBS3/ITGAV/COL1A2/DIAPH2/DSP/SPTAN1/SDC4/SUN2/SYNE1/CAPZA2/COL4A6/ANK3/SPTBN2/TNNT1/TMEM43/ACTG1/VCL/ITGB5/ITGA6/ENO1/ATP1B1/ITGB1/ATP1A4/AMPD3/HSPG2/COL5A2/ENO2/FBLN2/AGRN/TRIM55/TNNC2/FHL1/SGCE/INF2/COL9A3/MYOM3/MYL5/PDLIM7/COL1A1/ANKRD2/SGCZ/COL6A1/TLN2/MYOM1	6.43983662003724
NA	NA	hsa04382	Cornified envelope formation	68/1475	217/9376	1.99193314067016	S100A4/DST/KRT24/KRT6A/SPRR3/S100A10/S100A6/PPL/DSG1/EVPL/KRT14/KRT5/COL17A1/LAMB3/KRT17/S100A14/PLEC/S100A16/COL7A1/JUP/PKP1/KRT19/PKP3/TMEM79/COL4A5/KRT16/DSG2/LAMA3/ITGB4/KDSR/DSP/KRT8/S100A11/LAMC2/SPTLC3/PPP2R2A/COL4A6/KRT13/PPP2R3A/S100A2/PPP2R5C/S100A3/KRT6C/KRT10/DSG3/ELOVL1/ITGA6/KRT78/PPP2CB/PPP2R5E/PPP2R5B/ABCA12/KRT15/CLDN9/SPRR1A/SPRR1B/PPP2R1A/KRT6B/KRT27/ALOXE3/PPP2R2B/PRSS8/CLDN1/KRT72/DSC1/S100A8/CLDN4/SLC27A4	6.38746973288493
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	74/1475	248/9376	1.89673045379989	S100A10/AHNAK2/AHNAK/ANXA2/TUBA4A/FLNA/KLC3/NCKAP1/RRAS/MYO6/KIF5B/TUBA1A/ACTB/TUBB6/DYNLT1/BRK1/DYNLT3/MAP2K4/KLC1/GAPDH/PFN2/DYNLL1/ACTG1/DYNC1H1/RHOA/EXOC4/ARF6/KPNA4/VPS41/ABI1/SNX33/ACTR10/ARL8B/RAB7A/ACBD3/RIPK2/MAPK1/TAB3/EXOC5/DYNC1LI2/TXN/RALA/DYNC1I2/DCTN1/DYNC2H1/MAPK8/RAB9A/PIK3CA/TAB2/RAB5A/RAB5B/TNFRSF1A/PIK3C3/WASL/WASF3/ACTR3/DCTN3/PFN4/GCC2/DYNC2LI1/EXOC7/MYL12B/CYTH2/KPNA1/IRAK1/KPNA3/MYL5/IRAK4/SNX9/RAC1/TRADD/MYL12A/DNM2/DCTN2	6.18358822086311
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	37/1475	93/9376	2.52897393839985	LMO7/ARHGAP29/RAP1A/HEG1/TGFBR2/ACTB/FYN/NECTIN4/AFDN/BAIAP2/IQGAP1/FER/SRC/CTNNA1/SNAI2/ACTG1/NECTIN3/RHOA/VCL/ERBB2/ROCK1/MET/MAPK1/CDH1/SMURF2/SMURF1/PTPRM/WASL/WASF3/IGF1R/MYL12B/PTPRJ/MYL5/RAC1/RASIP1/CREBBP/MYL12A	6.40232917183463
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	63/1475	204/9376	1.96307078763709	THBS1/IGF2/WNT5A/EZR/CAV2/LUM/CCND1/FLNA/WNT2/DCN/CAMK2D/PPP1CB/RRAS/HIF1A/ITPR3/CAV1/SDC1/ACTB/ITGA2/ANK2/ITGAV/COL1A2/IQGAP1/SDC4/PTK2/TIAM1/ANK3/ARHGEF12/SRC/GAB1/ACTG1/GPC1/RHOA/VEGFA/ITGB5/SMAD2/ERBB2/WNT2B/ROCK1/ITGB1/MET/MAPK1/FZD6/HSPG2/SOS1/SOS2/PRKCA/FZD1/PIK3CA/WNT11/PTPN11/PIK3R1/RDX/IGF1R/FRS2/HPSE/PPP1R12B/COL1A1/BRAF/RAC1/RRAS2/RPS6KB2/DROSHA	6.00871890887213
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	46/1475	142/9376	2.05918357603247	FBXO2/STUB1/NEDD4L/HUWE1/PIAS1/UBE2E2/MID1/UBE2B/UBE2E3/UBA1/CUL4A/UBE3C/ANAPC16/PRKN/PIAS3/FBXW11/WWP1/SMURF2/BIRC6/UBE2Q1/UBE2G1/ELOB/COP1/HERC4/RNF7/SMURF1/BTRC/RBX1/UBE2J1/CUL4B/TRIP12/CDC16/ANAPC13/CDC27/UBE2W/CBLC/CUL7/UBE4B/UBE2M/DDB2/PIAS2/UBE3B/UBR5/CUL3/NEDD4/UBA6	5.49491643775946
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	37/1475	105/9376	2.23994834543987	OPTN/RRAS/HIF1A/PINK1/HUWE1/FIS1/BCL2L1/TAX1BP1/BNIP3L/ULK1/FKBP8/SRC/MAP1LC3A/PRKN/FOXO3/BNIP3/RAB7A/CITED2/MARCHF5/SMURF2/TBC1D17/TBC1D15/MAPK8/NBR1/TOMM7/GABARAPL2/SMURF1/AMFR/ATG9B/RAB5A/ATF4/RAB5B/EIF2AK3/USP15/RRAS2/BECN1/NLRX1	5.52046384453693
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	69/1475	250/9376	1.75442440677966	CAV2/ASAP2/EHD2/KIF5B/RAB11FIP1/CAV1/NEDD4L/TGFBR2/RAB22A/ARAP2/AGAP1/ASAP1/CLTB/PLD1/AP2S1/ARFGAP3/EPN2/CAPZA2/STAM/CHMP2B/SRC/SH3GLB2/CHMP4C/ARF5/RHOA/ACAP2/FOLR3/ARF6/ACAP3/SMAD2/RAB11FIP5/WASHC3/RAB10/RAB7A/PDCD6IP/SNX12/WWP1/SMURF2/SMAP1/VPS37B/EPN3/SMURF1/AP2B1/ZFYVE9/RAB5A/CHMP3/RAB5B/SH3GLB1/CHMP1B/WASL/ARFGEF1/EPS15/LDLR/CHMP4B/IGF1R/ACTR3/CBLC/PSD4/VPS37C/VPS4B/CYTH2/PIP5K1A/GBF1/VPS29/ARAP1/ARFGEF2/FGFR3/NEDD4/DNM2	5.22379493090641
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	17/1475	34/9376	3.17830508474576	PER3/NPAS2/NR1D1/NR1D2/RORA/CLOCK/PER2/FBXW11/BTRC/DBP/PRKAG2/RBX1/PER1/FBXL3/BHLHE40/CREB1/PRKAA1	5.49767230598903
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	62/1475	232/9376	1.69874926943308	GSN/MYH14/TMSB4X/EZR/ITGB6/RGCC/MYLK/NCKAP1/PPP1CB/RRAS/DIAPH1/ITGB4/ACTB/ITGA2/BAIAP2/ITGAV/DIAPH2/BRK1/IQGAP1/PTK2/ARHGAP35/TIAM1/PFN2/ARHGEF12/SRC/ACTG1/RHOA/VCL/ITGB5/ITGA6/CYRIB/PDGFD/ROCK1/ITGB1/MAPK1/APC/DOCK1/SOS1/SOS2/PIK3CA/SSH3/CYRIA/ARHGEF7/PIK3R1/WASL/RDX/SCIN/ACTR3/PFN4/MYL12B/PIP5K1A/CFL2/PPP1R12B/MYL5/C5/BRAF/RAC1/RRAS2/FGFR3/MYL12A/EGF/PIP4K2A	4.65626691780536
Cellular Processes	Cell motility	hsa04814	Motor proteins	54/1475	194/9376	1.76936571728115	MYH14/TUBA4A/KIF13A/KLC3/KIF1C/MYO6/MYO5B/KIF5B/MYO1E/TUBA1A/MYO15B/ACTB/TUBB6/DYNLT1/KIFAP3/DYNLT3/MYO18A/MYO9A/KIFC2/KLC1/CAPZA2/MYO1D/TNNT1/DYNLL1/DNAH5/ACTG1/DYNC1H1/KIFC3/KIF9/ACTR10/MYO3B/KIF3A/DYNC1LI2/DYNC1I2/MYO1C/DCTN1/DYNC2H1/KIF1B/HOOK3/DNAI4/MYO16/DNAH7/DCTN3/TNNC2/BICDL1/DYNC2LI1/MYL12B/KIF3B/MYL5/DNAL1/MYO5A/MYL12A/DCTN2/KIF16B	4.67848960180985
NA	NA	hsa04519	Cadherin signaling	94/1475	404/9376	1.47901325725793	KRT24/KRT6A/DSG1/KRT14/KRT5/VIM/WNT5A/KRT17/JUP/PKP1/WNT2/KRT19/DSC3/NCKAP1/PKP3/YWHAZ/PPP1CB/RRAS/GJA1/GABRP/DAAM1/MYO1E/KRT16/PCDH7/DSG2/DSC2/ACTB/DVL1/PCDH9/FAT1/AFDN/YAP1/ERBIN/WWTR1/YWHAQ/DSP/BRK1/KRT8/CELSR1/CDH11/ADAM10/PTK2/ARHGAP35/MYO1D/PRICKLE1/KRT13/AMOTL1/PCDH1/KRT6C/CTNNA1/SHOC2/ACTG1/KRT10/RHOA/VCL/DSG3/CDH10/LHFPL2/ERBB2/WNT2B/ROCK1/TMC6/MET/MAPK1/CDH1/STK3/KRT78/TAOK1/APC/FZD6/MYO1C/MAPK8/FZD1/KRT15/WNT11/GSK3B/LIMA1/PSENEN/AXIN1/KRT6B/KRT27/IGF1R/YWHAH/ACTR3/GABRB1/CDH2/KRT72/GABRB3/RAC1/LATS1/DSC1/RRAS2/CREBBP/PCDHGA10	4.25240089371233
NA	NA	hsa04518	Integrin signaling	44/1475	154/9376	1.81617433414044	THBS1/LAMB3/ITGB6/CCND1/FLNB/FLNA/FBN1/COL4A5/CCND2/LAMA3/ITGB4/ACTB/ITGA2/THBS3/VEGFB/ITGAV/COL1A2/LAMC2/PTK2/COL4A6/SRC/LAMB2/ACTG1/VCL/VEGFA/ITGB5/ERBB2/ITGA6/PDGFD/ITGB1/MET/CDH1/LAMC1/PIK3CA/GSK3B/PIK3R1/IGF1R/COL9A3/COL1A1/RAC1/TNC/COL6A1/TLN2/EGF	4.41236420277827
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	47/1475	169/9376	1.76781466252131	OPTN/RRAS/DAPK1/HIF1A/LAMP1/RB1CC1/BCL2L1/TAX1BP1/ULK1/MAP1LC3A/CTSD/WDFY3/BNIP3/VPS41/WDR41/IRS2/RUBCN/RAB7A/MAPK1/BIRC6/PPP2CB/MAPK8/NBR1/GABARAPL2/PIK3CA/ATG9B/RPTOR/TSC2/BAD/SH3GLB1/PIK3R1/ATG7/ATG16L2/EIF2AK3/PIK3C3/MTMR3/ATG10/ZFYVE1/IGF1R/WDR45/ULK2/STX7/RRAGB/RRAS2/BECN1/RPS6KB2/PRKAA1	4.35192397082739
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	36/1475	120/9376	1.90698305084746	CAMK2D/RAP1A/CALM2/SORT1/ARHGDIA/RPS6KA2/GAB1/RHOA/NTRK3/FOXO3/CALM1/RIPK2/MAPK1/SHC3/SOS1/PRDM4/SOS2/RPS6KA5/MAPK8/PIK3CA/PTPN11/GSK3B/ATF4/BAD/PIK3R1/MAP2K5/NGF/FRS2/RPS6KA3/KIDINS220/MAP3K3/IRAK1/IRAK4/RPS6KA6/BRAF/RAC1	4.32034808529405
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	32/1475	104/9376	1.95588005215124	SGMS2/LPCAT2/ETNK2/MBOAT2/PLAAT2/PLA2G4A/SGMS1/DGKB/PLD1/ACHE/AGPAT2/LPGAT1/PLPP2/PCYT1A/MBOAT1/TAFAZZIN/PLB1/PCYT2/CDS1/CDIPT/LPIN3/DGKA/GNPAT/PLD3/PNPLA6/LCLAT1/LPCAT4/AGPAT3/PLA2G12A/DGKE/GPD2/PLPP1	4.23520049023071
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	26/1475	78/9376	2.11887005649717	CAV2/CAV1/ACTB/CLTB/PTK2/SRC/CTNNA1/CD2AP/GAB1/ACTG1/RHOA/VCL/SEPTIN9/ITGB1/SEPTIN1/MET/CDH1/SHC3/DOCK1/PIK3CA/PIK3R1/ELMO3/WASL/ACTR3/RAC1/DNM2	4.28719067271489
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	43/1475	157/9376	1.74098240310914	WNT5A/CCND1/WNT2/LLGL2/YWHAZ/PPP1CB/AREG/CCND2/TGFBR2/CCN2/ACTB/DVL1/PATJ/YAP1/WWTR1/YWHAQ/PPP2R2A/CTNNA1/SNAI2/ACTG1/SMAD2/BMPR1A/WNT2B/FBXW11/CDH1/STK3/APC/PPP2CB/FZD6/BMP2/FZD1/WNT11/BTRC/GSK3B/PPP2R1A/AXIN1/PPP2R2B/YWHAH/DLG1/SMAD1/LATS1/TP53BP2/DLG2	4.04535305795173
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	78/1475	333/9376	1.48893571537639	THBS1/LAMB3/WNT5A/ITGB6/CCND1/WNT2/LLGL2/CDK6/COL4A5/CCND2/LAMA3/ITGB4/ITGA2/DVL1/ATP6AP1/PKM/PATJ/THBS3/PTGS2/ITGAV/COL1A2/LAMC2/PTK2/RBL2/UBR4/PPP2R2A/COL4A6/PPP2R3A/LAMB2/PPP2R5C/ATP6V1F/VEGFA/ITGB5/MAGI1/ITGA6/WNT2B/ITGB1/MAPK1/APC/PPP2CB/FZD6/SOS1/PPP2R5E/SOS2/ATP6V0A1/PPP2R5B/LAMC1/ATP6V1G1/RFNG/FZD1/ATP6V0B/PIK3CA/NFX1/WNT11/GSK3B/IFNAR1/TSC2/PPP2R1A/BAD/PIK3R1/AXIN1/MAML2/TNFRSF1A/ATP6V1D/PPP2R2B/ATP6V1A/COL9A3/DLG1/COL1A1/CREB3/TRADD/TNC/COL6A1/CREB1/RPS6KB2/CREBBP/EGF/DLG2	3.92516783377581
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	62/1475	253/9376	1.55774636564614	CAST/CAPN2/CAPNS1/PLCD1/H3-3B/ITPR3/DIAPH1/ACTB/TNIP1/BCL2L1/PTK2/PFN2/SRC/MAP1LC3A/ACTG1/RHOA/VCL/FOXO3/ARF6/BNIP3/SEPTIN9/ROCK1/H3-3A/FBXW11/ITGB1/RIPK2/MAPK1/TAB3/DOCK1/SEPTIN7/RPS6KA5/MAPK8/PIK3CA/TAB2/FNBP1/BTRC/GSK3B/UBE2V2/RPTOR/RBX1/PIK3R1/TNFRSF1A/PIK3C3/WASL/ACTR3/SHARPIN/PFN4/MYL12B/CYTH2/PLCB4/MYL5/PLCD3/RAC1/HK1/TRADD/RRAGB/BECN1/MALT1/RPS6KB2/TLN2/HK2/MYL12A	3.8856957260337
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	48/1475	184/9376	1.6582461311717	RHOD/WNT5A/SLIT2/SEMA3C/ABLIM3/PPP3CA/CAMK2D/RRAS/NGEF/EFNA5/FYN/DPYSL2/PPP3CC/EPHA4/PTK2/NFATC2/EFNB2/SEMA5A/ARHGEF12/SRC/SEMA4D/PLXNB2/RHOA/PPP3CB/ROCK1/ITGB1/MET/MAPK1/SRGAP2/PLXNA2/PRKCA/PLXNB1/RGS3/PIK3CA/PTPN11/GSK3B/SSH3/SEMA3B/PIK3R1/SLIT3/NFATC3/NEO1/MYL12B/CFL2/MYL5/RAC1/MYL12A/ABLIM2	3.8961245907604
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1475	110/9376	1.84919568567026	THBS1/EMP3/ID4/DCN/LTBP1/FBN1/THSD4/TGFBR2/ACVR2A/NBL1/NOG/RHOA/SMAD2/BMPR1A/ROCK1/MAPK1/SMURF2/PPP2CB/BMP2/CDKN2B/SMURF1/SKI/ZFYVE9/RBX1/PPP2R1A/NEO1/SMAD1/HFE/TFR2/RPS6KB2/CREBBP/FST	3.87078091583624
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1475	80/9376	1.9864406779661	GAS6/BCL2L1/SRC/GAB1/VEGFA/FOXO3/ERBB2/PDGFD/MET/MAPK1/JAK2/SHC3/SOS1/SOS2/PRKCA/PIK3CA/GSK3B/BAD/PIK3R1/IGF1R/EIF4E2/BRAF/FGFR3/RPS6KB2/EGF	3.82832259332183
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	13/1475	31/9376	2.66567523236741	IMMP2L/SRP14/SEC62/SEC11C/SEC61G/TMEM208/SRPRA/SPCS3/SPCS2/SPCS1/SEC63/UBL4A/GET3	4.01348957831795
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	45/1475	178/9376	1.6070081889164	WNT5A/CCND1/WNT2/PPP3CA/CAMK2D/DAAM1/CCND2/DVL1/ROR2/CELSR1/PPP3CC/NFATC2/PRICKLE1/DKK2/TBL1XR1/RHOA/SFRP2/CTNNBIP1/PPP3CB/WNT2B/CTBP2/FBXW11/PORCN/APCDD1/APC/FZD6/MAPK8/PRKCA/FZD1/WNT11/BTRC/GSK3B/TLE4/RBX1/SENP2/AXIN1/NFATC1/NFATC3/LGR6/TLE1/PLCB4/DKK1/RAC1/CREBBP/FOSL1	3.53263254807612
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	26/1475	87/9376	1.89967660237678	CCND1/EREG/AREG/TGFBR2/RALB/RHOA/SMAD2/RALGDS/MAPK1/APC/RALA/SOS1/SOS2/MAPK8/APPL1/PIK3CA/GSK3B/BAD/PIK3R1/AXIN1/DDB2/BRAF/RAC1/RPS6KB2/MSH3/EGF	3.64252204107521
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	43/1475	170/9376	1.60784845463609	MYH14/EZR/CCND1/TUBA4A/LLGL2/RAP1A/NEDD4L/TUBA1A/ACTB/PATJ/AFDN/TIAM1/PPP2R2A/AMOTL1/SRC/YBX3/ACTG1/RHOA/MAGI1/ERBB2/RAB13/ROCK1/ITGB1/PPP2CB/EPB41L4B/MAPK8/CLDN9/PRKAG2/PPP2R1A/PPP2R2B/RDX/RAPGEF2/ACTR3/CLDN1/MYL12B/DLG1/RAC1/MICALL2/CLDN4/NEDD4/PRKAA1/MYL12A/DLG2	3.45561149317574
NA	NA	hsa04517	IgSF CAM signaling	68/1475	299/9376	1.44565047332918	LMO7/MYH14/EZR/SPTBN1/SLITRK6/SLIT2/TUBA4A/MYLK/RAP1A/MBP/TUBA1A/ACTB/FYN/NECTIN4/TUBB6/ANK2/TRIO/AFDN/MAP2/BAIAP2/IQGAP1/SPTAN1/PTK2/EPB41L2/ANK3/SRC/SPTBN2/DYNLL1/CD2AP/ACTG1/IL1RAPL2/NECTIN3/RHOA/VCL/NTRK3/PTPRD/MAGI1/ARF6/KIRREL3/ITGB1/MAPK1/CDH1/CADM2/EPB41L1/MAGI2/SRGAP2/PLXNA2/MAPK8/PRKCA/PALS2/PIK3CA/PTPN11/GSK3B/NLGN1/PIK3R1/WASL/CASK/RDX/SLIT3/RAPGEF2/CXADR/ACTR3/MYL12B/CDH2/RAC1/MYL12A/PPFIA4/CADM4	3.38375893864172
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	28/1475	98/9376	1.81617433414044	PLCD1/ITPR3/BPNT2/CALM2/DGKB/CALM1/INPP4B/PI4KA/PPIP5K2/ITPKC/PRKCA/MTMR2/PIK3CA/MTM1/CDS1/PIK3R1/PIK3C3/MTMR3/ITPKB/CDIPT/DGKA/PIP5K1A/PLCB4/MTMR6/PLCD3/DGKE/INPP5F/PIP4K2A	3.50921037600165
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	36/1475	138/9376	1.6582461311717	PPP3CA/CAMK2D/YWHAZ/PPP1CB/ITPR3/CALM2/YWHAQ/ADCY7/PPP3CC/SLK/RPS6KA2/PPP2R5C/CPEB4/ANAPC16/CPEB2/CALM1/PPP3CB/FBXW11/MAPK1/PPP2CB/PPP2R5E/PPP2R5B/ADCY9/BTRC/RBX1/SPDYA/PPP2R1A/CDC16/ANAPC13/IGF1R/CDC27/SMC1A/YWHAH/RPS6KA3/RPS6KA6/SPDYE2	3.36573172935452
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	38/1475	149/9376	1.62114890228643	RRAS/AVPR1A/PLA2G4A/FYN/DGKB/PLD1/RALB/ADCY7/AGPAT2/GAB2/PLPP2/GAB1/RHOA/ARF6/RALGDS/PDGFD/MAPK1/SHC3/RALA/SOS1/SOS2/PRKCA/PIK3CA/PTPN11/ADCY9/TSC2/PIK3R1/PTGFR/DGKA/CYTH2/PIP5K1A/PLCB4/AGPAT3/DGKE/RRAS2/PLPP1/DNM2/EGF	3.30216837188099
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	33/1475	125/9376	1.67814508474576	CERS6/GNAQ/SGMS2/ASAH1/FYN/SGMS1/PLD1/GAB2/SPTLC3/PPP2R2A/PPP2R3A/PPP2R5C/SMPD1/CTSD/RHOA/ORMDL2/ROCK1/MAPK1/PPP2CB/PPP2R5E/PPP2R5B/MAPK8/SGPP2/PRKCA/PIK3CA/NSMAF/PPP2R1A/PIK3R1/TNFRSF1A/PPP2R2B/PLCB4/RAC1/TRADD	3.29779687234161
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	55/1475	238/9376	1.46896453496653	IGF2/RRAS/RAP1A/RASAL2/PLAAT2/EFNA5/PLA2G4A/CALM2/PLD1/AFDN/GNB1/RALB/VEGFB/GAB2/BCL2L1/RASSF5/TIAM1/ABL2/RASGRF1/GAB1/SHOC2/RHOA/VEGFA/ARF6/RALGAPA1/CALM1/GNB5/RALGDS/PDGFD/MET/MAPK1/SHC3/RALA/SOS1/SOS2/RASA2/MAPK8/PRKCA/RALGAPB/PIK3CA/PTPN11/GNB2/RAB5A/STK4/RAB5B/BAD/PIK3R1/RIN1/NGF/IGF1R/RAC1/PLA2G12A/RRAS2/FGFR3/EGF	3.1662377310645
Organismal Systems	Immune system	hsa04611	Platelet activation	33/1475	126/9376	1.66482647296207	COL3A1/GNAQ/MYLK/PPP1CB/ITPR3/RAP1A/GUCY1A1/ACTB/ITGA2/PLA2G4A/FYN/COL1A2/ADCY7/ARHGAP35/ARHGEF12/SRC/STIM1/ACTG1/RHOA/ROCK1/ITGB1/MAPK1/PRKG1/PIK3CA/ADCY9/PIK3R1/SNAP23/GUCY1B1/MYL12B/PLCB4/COL1A1/TLN2/MYL12A	3.24611071412871
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	78/1475	362/9376	1.36965633486281	THBS1/IGF2/LAMB3/ITGB6/CCND1/EREG/CDK6/YWHAZ/AREG/COL4A5/CCND2/LAMA3/ITGB4/ITGA2/EFNA5/THBS3/GNB1/VEGFB/ITGAV/COL1A2/YWHAQ/LAMC2/BCL2L1/PTK2/RBL2/PPP2R2A/COL4A6/PPP2R3A/LAMB2/PPP2R5C/VEGFA/ITGB5/FOXO3/MAGI1/ERBB2/GNB5/ITGA6/PDGFD/ITGB1/MET/MAPK1/JAK2/PPP2CB/MAGI2/SOS1/PPP2R5E/SOS2/PPP2R5B/LAMC1/PRKCA/PIK3CA/GNB2/GSK3B/IFNAR1/RPTOR/ATF4/TSC2/PPP2R1A/BAD/PIK3R1/PKN2/PPP2R2B/NGF/IGF1R/YWHAH/EIF4E2/COL9A3/COL1A1/CREB3/RAC1/TNC/COL6A1/FGFR3/CREB1/RPS6KB2/PRKAA1/PRL/EGF	3.09909064479158
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	32/1475	122/9376	1.6673075854404	CCND1/PFKP/ADIPOR1/CAB39/SCD5/RAB2A/PPP2R2A/ULK1/PPP2R3A/PPP2R5C/FOXO3/TBC1D1/IRS2/RAB10/LEPR/HMGCR/PPP2CB/PPP2R5E/PPP2R5B/PIK3CA/CPT1A/PRKAG2/RPTOR/TSC2/PPP2R1A/PIK3R1/PPP2R2B/IGF1R/CREB3/CREB1/RPS6KB2/PRKAA1	3.20539715272503
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	39/1475	157/9376	1.57903055165713	THBS1/GAS6/CAMK2D/HIF1A/MFGE8/ATP11B/PTGS2/ITGAV/ADAM10/P2RY2/ODC1/PTK2/NFATC2/SLC2A1/TMEM30A/DUSP7/ITGB5/DUSP4/VPS41/RAB7A/GULP1/MAPK1/JAK2/PBX1/DOCK1/PTPN11/CPT1A/RAB5A/RAB5B/NFATC1/NFATC3/XKR6/VPS8/ANO6/ADAM9/MERTK/RAC1/PANX1/CREB1	3.16118574876417
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	15/1475	44/9376	2.16702619414484	VAMP2/ARHGDIA/DYNLL1/DYNC1H1/DYNC1LI2/DYNC1I2/DCTN1/DYNC2H1/ADCY9/RAB5A/RAB5B/DYNC2LI1/CREB3/CREB1/DCTN2	3.3524336762151
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	25/1475	89/9376	1.78556465435155	THBS1/LAMB3/ITGB6/COL4A5/LAMA3/SDC1/ITGB4/ITGA2/THBS3/ITGAV/COL1A2/LAMC2/SDC4/COL4A6/LAMB2/ITGB5/ITGA6/ITGB1/HSPG2/LAMC1/AGRN/COL9A3/COL1A1/TNC/COL6A1	3.21721313104826
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	39/1475	158/9376	1.56903668740614	WNT5A/WNT2/DVL1/CAB39/CLIP1/RPS6KA2/ULK1/ATP6V1F/RHOA/WNT2B/MAPK1/FZD6/SOS1/SOS2/ATP6V1G1/PRKCA/FZD1/PIK3CA/WNT11/MAPKAP1/GSK3B/RPTOR/TSC2/PIK3R1/TNFRSF1A/ATP6V1D/LAMTOR4/LPIN3/IGF1R/ULK2/RPS6KA3/LAMTOR2/EIF4E2/ATP6V1A/RPS6KA6/BRAF/RRAGB/RPS6KB2/PRKAA1	3.11667183640828
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	65/1475	300/9376	1.37726553672316	IGF2/EREG/FLNA/PPP3CA/RRAS/AREG/RAP1A/TGFBR2/EFNA5/PLA2G4A/CDC25B/VEGFB/PPP3CC/MAP2K4/RPS6KA2/RASGRF1/MAPKAPK3/DUSP7/MAP3K2/VEGFA/DUSP4/ERBB2/PPP3CB/DUSP10/PPM1A/MAP4K4/PDGFD/MET/MAPK1/STK3/TAOK1/SOS1/SOS2/RPS6KA5/RASA2/MAPK8/PRKCA/TAB2/STK4/ATF4/TNFRSF1A/NFATC1/NFATC3/MAP2K5/RAPGEF2/NGF/IGF1R/MAP3K14/RPS6KA3/MAP3K3/IRAK1/IRAK4/RPS6KA6/MAP3K13/BRAF/RAC1/MAP4K3/TRADD/MAP3K21/RPS6KA4/RRAS2/ELK4/MAP3K6/FGFR3/EGF	2.86946634449604
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	46/1475	200/9376	1.46202033898305	MYH14/EZR/TUBA4A/NCKAP1/MYO6/MYO5B/TMED10/MYO1E/TUBA1A/ACTB/FYN/TUBB6/BAIAP2/BRK1/GAPDH/MYO1D/ARHGEF12/SRC/BAIAP2L1/ACTG1/RHOA/ARF6/ABI1/ROCK1/SEC24B/ITGB1/MAPK1/TAB3/MYO1C/MAPK8/TAB2/PTPN11/CLDN9/TNFRSF1A/WASL/WASF3/ACTR3/CLDN1/CYTH2/IRAK1/IRAK4/MYO5A/RAC1/TRADD/CLDN4/ARHGEF11	2.85357970285824
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	34/1475	138/9376	1.56612134610661	GNAQ/ACTB/BAIAP2/MAP2K4/PTK2/NFATC2/RPS6KA2/ARHGEF12/SRC/ACTG1/RHOA/ARF6/ROCK1/SKAP2/ITGB1/MAPK1/DOCK1/MAPK8/PIK3CA/TAB2/GSK3B/ARHGEF7/PIK3R1/PKN2/WASL/NFATC1/NFATC3/ACTR3/PIP5K1A/RPS6KA3/IRAK1/IRAK4/RPS6KA6/RAC1	2.89468101219858
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	26/1475	99/9376	1.66941277178565	HIF1A/PLA2G4A/DGKB/PLD1/PLPP2/PCYT1A/SLC44A2/RALGDS/PDGFD/MAPK1/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/TSC2/PIK3R1/DGKA/WASF3/PIP5K1A/SLC44A3/RAC1/DGKE/RPS6KB2/PLPP1/EGF	2.89299997904705
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1475	110/9376	1.61804622496148	EDN1/CAMK2D/HIF1A/PFKP/TIMP1/PGK1/GAPDH/PDK1/SLC2A1/VEGFA/ERBB2/ENO1/ALDOC/MAPK1/ELOB/PRKCA/PIK3CA/ENO2/RBX1/PIK3R1/IGF1R/EIF4E2/HK1/RPS6KB2/CREBBP/LTBR/HK2/EGF	2.81716166609736
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/1475	23/9376	2.48736919675755	MVD/HMGCR/PCYOX1/GGPS1/ICMT/PDSS2/IDI1/PMVK/NUS1	3.08565844150442
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	10/1475	27/9376	2.35430006277464	HACD2/HACD4/SCD5/ELOVL6/SCP2/ELOVL1/ACOX1/ELOVL7/ACOT7/HSD17B12	3.04477228810099
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1475	67/9376	1.80262079433342	GNAQ/PPP3CA/CAMK2D/PPP1CB/ITPR3/RAP1A/CALM2/PPP3CC/RPS6KA2/CALM1/PPP3CB/MAPK1/PRKCA/ATF4/RPS6KA3/PLCB4/RPS6KA6/BRAF/CREBBP	2.84863568831699
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	37/1475	157/9376	1.49805462593112	CAPN2/CCND1/IGFBP3/CDK6/PPP3CA/PPP1CB/RRAS/ITPR3/CCND2/TGFBR2/CALM2/PPP3CC/ZFP36L2/HIPK3/RASSF5/NFATC2/RBL2/HIPK2/NBN/FOXO3/SMAD2/CALM1/VDAC2/PPP3CB/FBXW11/MAPK1/CDKN2B/PIK3CA/BTRC/TSC2/HIPK1/PIK3R1/NFATC1/NFATC3/MCU/TRPM7/RRAS2	2.71910209417038
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/1475	77/9376	1.73362095531587	CCND1/CDK6/TGFBR2/PLD1/RALB/BCL2L1/VEGFA/SMAD2/ERBB2/RALGDS/MAPK1/RALA/MAPK8/PIK3CA/BAD/PIK3R1/DDB2/BRAF/RAC1/RPS6KB2/EGF	2.79279838274457
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1475	138/9376	1.52005895357406	PPP1CB/CALM2/PYGL/PHKA1/TRIP10/CALM1/IRS2/MAPK1/SHC3/SOS1/SOS2/MAPK8/PIK3CA/PYGB/GSK3B/PRKAG2/RPTOR/TSC2/BAD/PPP1R3F/PIK3R1/PRKAR2B/PRKAR1A/EXOC7/EIF4E2/BRAF/SOCS4/HK1/PRKAR1B/RPS6KB2/HK2/PRKAA1/PRKAR2A	2.65915565362061
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1475	59/9376	1.83156564205688	CCND1/CTNNA1/FOXO3/ERBB2/MAPK1/CDH1/APC/SOS1/SOS2/PIK3CA/GSK3B/BAD/PIK3R1/AXIN1/DDB2/BRAF/EGF	2.76837623717314
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	39/1475	170/9376	1.45828115653041	IGF2/WNT5A/CCND1/WNT2/CDK6/TGFBR2/GSTO2/ACTB/DVL1/TXNRD2/BCL2L1/GAB1/ACTG1/SMAD2/WNT2B/MGST1/ARID1B/MET/MAPK1/APC/SHC3/FZD6/SOS1/SOS2/NQO1/PRKCA/FZD1/PIK3CA/WNT11/GSK3B/BAD/PIK3R1/AXIN1/IGF1R/PBRM1/SMARCC2/DDB2/BRAF/RPS6KB2	2.60532311883634
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	33/1475	139/9376	1.50912327764907	KRT24/KRT14/KRT17/KRT19/GNAQ/ITPR3/KRT16/FKBP5/CALM2/ADCY7/KRT13/SRC/CTSD/NCOA1/KRT10/CALM1/MAPK1/SHC3/SOS1/SOS2/KRT15/PIK3CA/ADCY9/ATF4/PIK3R1/NCOA2/KRT27/EBAG9/ESR2/PLCB4/CREB3/GPER1/CREB1	2.61279598281734
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	51/1475	235/9376	1.37951965380454	COX7A1/ACSL3/ACTB/MT-ND4L/MT-ND2/MT-ND3/ATP5F1E/ADCY7/COX17/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/ACSL1/MT-CO2/NDUFA4L2/RPS6KA2/ATP5ME/ACTG1/NDUFB7/NDUFB2/NDUFAF3/NDUFS4/ARID1B/PRKG1/NDUFC1/SOS1/SOS2/COX7A2L/ADCY9/NDUFAF8/CPT1A/COX7A2/PRKAG2/RPTOR/NDUFB1/TSC2/UQCRC1/ZNF516/FRS2/RPS6KA3/SMARCC2/RPS6KA6/CREB3/KDM3A/COA1/CREB1/RPS6KB2/NDUFAF2/PRKAA1/UQCRHL	2.54572780068396
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/1475	166/9376	1.45512762916071	ATP2B4/GNAQ/PPP3CA/MYLK/PPP1CB/KCNMA1/ITPR3/KCNMB4/GUCY1A1/CALM2/ADCY7/PPP3CC/NFATC2/MEF2A/RHOA/CNGA1/CALM1/VDAC2/PPP3CB/IRS2/ATP1B1/ADRA1B/ROCK1/ATP1A4/MAPK1/PRKG1/ADCY9/ATF4/BAD/ATP2B1/NFATC1/NFATC3/GUCY1B1/PDE5A/PLCB4/MEF2D/CREB3/CREB1	2.55621893273911
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/1475	227/9376	1.37213171059509	COX7A1/HIF1A/GSTO2/MT-ND4L/PLD1/MT-ND2/MT-ND3/ATP5F1E/MAP2K4/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/PTK2/MT-CO2/NDUFA4L2/SRC/ABL2/VEGFA/NDUFB7/FOXO3/VDAC2/NDUFB2/MGST1/NDUFS4/MET/MAPK1/NDUFC1/SOS1/SOS2/NQO1/MAPK8/AHR/COX7A2L/PIK3CA/PTPN11/COX7A2/NDUFB1/BAD/UQCRC1/PIK3R1/MAP3K14/PTPRJ/BRAF/RAC1/PRKD2/UQCRHL/PRKD1/EGF	2.45224248079831
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	19/1475	71/9376	1.70106469324421	TH/CCND1/CCND2/SOCS6/SRC/FOXO3/SOCS5/MAPK1/JAK2/SHC3/SOS1/SOS2/MAPK8/PIK3CA/GSK3B/PIK3R1/ESR2/SOCS4/PRL	2.56194439195466
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1475	142/9376	1.47724039150155	CAV2/EDN1/CAV1/SDC1/GSTO2/ACVR2A/ACTB/CALM2/THBD/ITGAV/MAP2K4/SDC4/PTK2/SRC/MEF2A/ACTG1/GPC1/RHOA/VEGFA/BMPR1A/CALM1/MGST1/TXN/NQO1/MAPK8/PIK3CA/PIK3R1/TNFRSF1A/MAP2K5/SUMO2/RAC1/KLF2/PRKAA1	2.47586549807326
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	25/1475	101/9376	1.57341835878503	COL3A1/CCND1/F3/EDN1/PLCD1/COL4A5/TGFBR2/DIAPH1/THBD/VEGFB/COL1A2/COL4A6/VEGFA/SMAD2/MAPK1/JAK2/MAPK8/PRKCA/PIK3CA/PIK3R1/NFATC1/PLCB4/COL1A1/PLCD3/RAC1	2.50331751829481
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	39/1475	174/9376	1.42475745178258	CAPN2/CRYAB/FBXO2/STUB1/MARCHF6/DNAJB2/ERO1A/SEC62/DAD1/BAG1/SEC31A/SAR1B/DNAJC1/PRKN/SSR4/SEC61G/DNAJC3/SEC23A/SEC24B/UBE2G1/UBXN6/SELENOS/MAPK8/MAN1A2/KRTCAP2/AMFR/MBTPS1/RBX1/ATF4/MAGT1/UBE2J1/EIF2AK3/ATXN3/CKAP4/UBE4B/SEC63/MAN1B1/MBTPS2/FBXO6	2.44351570029159
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	22/1475	86/9376	1.62610957824202	EREG/CAMK2D/AREG/MAP2K4/PTK2/SRC/ABL2/GAB1/ERBB2/MAPK1/SHC3/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/GSK3B/BAD/PIK3R1/BRAF/RPS6KB2/EGF	2.52018448602078
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	53/1475	250/9376	1.3476013559322	ASAH1/OSBPL1A/ATP6AP1/LAMP1/SUMF1/CLTB/SORT1/OSBPL3/AP2S1/CTSA/SMPD1/SCARB2/CTSD/ATP6V1F/PSAP/VPS13C/OSBPL5/CTSZ/VPS41/ARL8B/BLOC1S1/RAB7A/OSBPL6/SLC17A5/ATP6V0A1/ABCA5/ATP6V1G1/ATP6V0B/AP2B1/RPTOR/DMXL1/SPG11/NPC2/ATP6V1D/LAMTOR4/ACP2/ABCA2/AP1G1/CTSF/LAMTOR2/HYAL2/HGSNAT/NCOA7/ATP6V1A/VPS29/OSBP/OSBPL2/RRAGB/SLC29A3/HYAL1/GNS/ARSA/GALC	2.4068656644418
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1475	212/9376	1.37926447073873	THBS1/GNAQ/RRAS/RAP1A/ACTB/EFNA5/CALM2/AFDN/RALB/VEGFB/ADCY7/RASSF5/TIAM1/PFN2/SRC/ACTG1/RHOA/VEGFA/MAGI1/CALM1/RALGDS/PDGFD/ITGB1/MET/MAPK1/CDH1/RALA/MAGI2/PRKCA/PIK3CA/ADCY9/PIK3R1/RAPGEF2/NGF/IGF1R/PFN4/PLCB4/BRAF/RAC1/SIPA1L3/FGFR3/TLN2/SIPA1L2/PRKD2/PRKD1/EGF	2.41328252350706
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	77/1475	388/9376	1.26149222435785	COX7A1/CAPN2/WNT5A/TUBA4A/WNT2/KLC3/GNAQ/PPP3CA/ITPR3/KIF5B/TUBA1A/DVL1/RTN3/MT-ND4L/CALM2/TUBB6/MT-ND2/RB1CC1/MT-ND3/PTGS2/ATP5F1E/PPP3CC/MT-ND4/MT-ND5/ADAM10/MT-CYB/RTN4/MT-ATP8/KLC1/MT-CO2/APBB1/GAPDH/NDUFA4L2/ULK1/DKK2/SLC39A6/NDUFB7/SLC39A14/CALM1/VDAC2/PPP3CB/WNT2B/IRS2/NDUFB2/NDUFS4/MAPK1/APC/FZD6/NDUFC1/MAPK8/FZD1/SLC39A13/COX7A2L/PIK3CA/WNT11/GSK3B/COX7A2/PSENEN/NDUFB1/ATF4/BAD/UQCRC1/PIK3R1/AXIN1/TNFRSF1A/EIF2AK3/PIK3C3/MCU/ULK2/PLCB4/DKK1/CDK5R1/BRAF/LPL/BACE1/BECN1/UQCRHL	2.2729177894522
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	19/1475	73/9376	1.65446018110053	CCND1/CDK6/KIF5B/RASSF5/FOXO3/ERBB2/MET/MAPK1/FHIT/SOS1/SOS2/PRKCA/PIK3CA/STK4/BAD/PIK3R1/DDB2/BRAF/EGF	2.4253463428792
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	20/1475	78/9376	1.62990004345937	PLCD1/TPI1/INPP4B/PI4KA/PPIP5K2/ITPKC/MTMR2/PIK3CA/MTM1/PIK3C3/MTMR3/ITPKB/CDIPT/PIP5K1A/PLCB4/MTMR6/PLCD3/INPP5K/INPP5F/PIP4K2A	2.41359716026015
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	93/1475	480/9376	1.23159322033898	COX7A1/CAPN2/WNT5A/TUBA4A/WNT2/KLC3/GNAQ/PPP3CA/OPTN/CAMK2D/ITPR3/KIF5B/TUBA1A/PINK1/DVL1/MT-ND4L/CALM2/TUBB6/MT-ND2/RB1CC1/MT-ND3/PTGS2/ATP5F1E/PPP3CC/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/BCL2L1/KLC1/MT-CO2/NDUFA4L2/ATXN1/CHMP2B/ULK1/UBA1/MAP1LC3A/SPTBN2/DKK2/DNAH5/PRKN/NDUFB7/CALM1/WDR41/VDAC2/ACTR10/PPP3CB/WNT2B/NDUFB2/NDUFS4/IFT57/MAPK1/APC/FZD6/UBE2G1/DCTN1/NDUFC1/MAPK8/PRKCA/FZD1/COX7A2L/WNT11/GSK3B/COX7A2/NDUFB1/RAB5A/ATF4/SPG11/BAD/UQCRC1/DNAH7/AXIN1/TNFRSF1A/UBE2J1/EIF2AK3/PIK3C3/PRNP/ATXN3/ZFYVE1/MCU/DCTN3/ULK2/PLCB4/HTT/DKK1/CDK5R1/DNAL1/BRAF/RAC1/BECN1/UQCRHL/GPX1/DCTN2	2.25055531018368
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	30/1475	130/9376	1.46691003911343	COL3A1/EDN1/COL4A5/TGFBR2/GNB1/VEGFB/COL1A2/ADCY7/MAP2K4/COL4A6/SRC/GNA15/VEGFA/SMAD2/GNB5/MAPK1/SHC3/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/ADCY9/GNB2/ATF4/PIK3R1/PLCB4/COL1A1/CREB3/CREB1	2.31616002048439
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1475	60/9376	1.69509604519774	PPP3CA/PLA2G4A/PTGS2/PPP3CC/PTK2/NFATC2/SRC/MAPKAPK3/VEGFA/PPP3CB/MAPK1/PRKCA/PIK3CA/BAD/PIK3R1/RAC1	2.33370695378042
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	22/1475	90/9376	1.55383804143126	ADIPOR1/SESN3/RB1CC1/ADCY7/ULK1/FOXO3/IRS2/EHMT1/APPL1/PIK3CA/ADCY9/PRKAG2/RPTOR/ATF4/TSC2/PIK3R1/IGF1R/EIF4E2/CREB3/CREB1/RPS6KB2/PRKAA1	2.28102641882106
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1475	41/9376	1.86047126911947	THBS1/CCND1/DAPK1/SRC/VEGFA/ERBB2/MAPK1/CDH1/RPS6KA5/BRAF/FGFR3/EGF	2.38567763179842
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1475	70/9376	1.63455690072639	HIF1A/RAP1A/GAB1/SLC2A1/VEGFA/MET/MAPK1/ELOB/SOS1/SOS2/PIK3CA/PTPN11/RBX1/BAD/PIK3R1/BRAF/RAC1/CREBBP	2.30238891011088
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	14/1475	51/9376	1.74495181123297	LPCAT2/PLAAT2/PLA2G4A/PLD1/PAFAH1B1/PLPP2/PEDS1/PLB1/PAFAH1B2/PLD3/LPCAT4/PLA2G12A/PLA2G7/PLPP1	2.30477994178049
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/1475	51/9376	1.74495181123297	ACTB/ATP6AP1/ERO1A/ACTG1/ATP6V1F/SEC61G/ATP6V0A1/ATP6V1G1/PRKCA/ATP6V0B/ADCY9/ATP6V1D/ATP6V1A/SLC12A2	2.30477994178049
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	31/1475	138/9376	1.42793416850897	COX7A1/ATP6AP1/MT-ND4L/MT-ND2/MT-ND3/ATP5F1E/COX17/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/MT-CO2/NDUFA4L2/ATP5ME/ATP6V1F/LHPP/NDUFB7/NDUFB2/NDUFS4/NDUFC1/ATP6V0A1/ATP6V1G1/COX7A2L/ATP6V0B/COX7A2/NDUFB1/UQCRC1/ATP6V1D/ATP12A/ATP6V1A/UQCRHL	2.18810493646467
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1475	56/9376	1.70266343825666	CCND1/CCND2/FBXW11/SPOPL/SMURF2/KIF3A/SMURF1/CDON/BTRC/GSK3B/IQCE/EVC/EVC2/CUL3/EFCAB7	2.27863115592056
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	30/1475	133/9376	1.43382184274245	TH/GNAQ/PPP3CA/CAMK2D/PPP1CB/ITPR3/KIF5B/CALM2/GNB1/PPP3CC/PPP2R2A/PPP2R3A/PPP2R5C/CLOCK/CALM1/GNB5/PPP3CB/PPP2CB/PPP2R5E/PPP2R5B/MAPK8/PRKCA/GNB2/GSK3B/ATF4/PPP2R1A/PPP2R2B/PLCB4/CREB3/CREB1	2.17706490151154
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	18/1475	71/9376	1.61153497254715	HIF1A/PFKP/PKM/SLC16A3/SLC1A5/PDK1/SLC2A1/NTRK3/ERBB2/MET/MAPK1/PIK3CA/GLS/PIK3R1/SIRT3/HK1/FGFR3/HK2	2.23477035500282
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1475	107/9376	1.48518929193727	GNAQ/PPP3CA/CAMK2D/ITPR3/PFKP/PKM/CALM2/PPP3CC/SIK1/PYGL/PHKA1/SLC2A1/CALM1/PPP3CB/PPP4R3B/PYGB/CPT1A/PRKAG2/ATF4/PLCB4/PPARA/CREB3/CREB1/CREBBP/PRKAA1	2.18085741738808
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	30/1475	134/9376	1.42312167973691	MYH14/GNAQ/EDN1/MYLK/PPP1CB/KCNMA1/AVPR1A/ITPR3/KCNMB4/GUCY1A1/PLA2G4A/CALM2/ADCY7/ARHGEF12/RHOA/CALM1/ADRA1B/ROCK1/MAPK1/EDN2/PRKG1/PRKCH/PRKCA/ADCY9/GUCY1B1/PLCB4/PPP1R12B/BRAF/PLA2G12A/ARHGEF11	2.13145080156799
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1475	33/9376	1.92624550590652	VAMP2/VAMP4/STX8/VTI1B/VTI1A/STX11/SNAP23/STX19/STX7/STX18	2.30292888362142
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	11/1475	38/9376	1.84007136485281	SFN/NR3C2/NEDD4L/ATP1B1/ATP1A4/MAPK1/FXYD4/PRKCA/PIK3CA/PIK3R1/SCNN1A	2.2419280067184
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	25/1475	109/9376	1.4579381122687	PPP1CB/SLC27A6/PYGL/RPS6KA2/SLC2A1/IRS2/OGA/MAPK8/PIK3CA/PYGB/PTPN11/GSK3B/CPT1A/PRKAG2/PIK3R1/TNFRSF1A/PTPA/RPS6KA3/PPARA/RPS6KA6/CREB3/CREB1/SLC27A4/RPS6KB2/PRKAA1	2.07773939574364
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1475	48/9376	1.72158192090395	CD9/CD81/LAMP1/PDCD6IP/HSPG2/CLDN9/EPCAM/CHMP1B/LDLR/CHMP4B/CLDN1/VPS4B/CLDN4	2.16547219126914
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1475	115/9376	1.43714664701548	AKAP13/GNAQ/ITPR3/PDE4D/PTHLH/OXSR1/PLD1/ADCY7/MEF2A/RHOA/MAFB/MAPK1/WNK1/PRKCA/ADCY9/ATF4/RUNX2/STK39/MMP24/PLCB4/MEF2D/CREB3/BRAF/CREB1/ARHGEF11/WNK3	2.03792288915454
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	21/1475	89/9376	1.4998743096553	TUBA4A/GNAQ/GJA1/ITPR3/TUBA1A/GUCY1A1/TUBB6/ADCY7/SRC/MAP3K2/PDGFD/MAPK1/PRKG1/SOS1/SOS2/PRKCA/ADCY9/MAP2K5/GUCY1B1/PLCB4/EGF	2.04719265815775
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	24/1475	105/9376	1.45293946731235	PPP3CA/RRAS/ITPR3/CALM2/CYLD/PTGS2/PPP3CC/NFATC2/ARHGEF12/SRC/RHOA/CALM1/PPP3CB/MAPK1/MAPK8/PIK3CA/PTPN11/PIK3R1/NFATC1/NFATC3/MAP3K14/CLEC7A/RRAS2/MALT1	2.01656461114484
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1475	116/9376	1.42475745178258	EZR/CD99/RAP1A/ACTB/AFDN/ARHGAP5/PTK2/RASSF5/ARHGAP35/CTNNA1/ACTG1/RHOA/VCL/ROCK1/ITGB1/PRKCA/PIK3CA/PTPN11/CLDN9/PIK3R1/CLDN1/MYL12B/MYL5/RAC1/CLDN4/MYL12A	1.98886417711691
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1475	154/9376	1.36213075060533	CCND1/CAMK1D/GNAQ/PPP3CA/MYLK/CAMK2D/PPP1CB/ITPR3/GUCY1A1/ACTB/PLA2G4A/CALM2/PTGS2/ADCY7/PPP3CC/NFATC2/SRC/ACTG1/RHOA/CALM1/PPP3CB/ROCK1/MAPK1/PRKCA/ADCY9/PRKAG2/NFATC1/NFATC3/MAP2K5/GUCY1B1/PLCB4/PPP1R12B/PRKAA1	1.9577346332251
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/1475	30/9376	1.90698305084746	PIGP/PIGT/PGAP4/PIGK/PGAP3/GPAA1/PIGN/MPPE1/PIGA	2.14974787228021
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	27/1475	122/9376	1.40679077521534	PPP3CA/FYN/PPP3CC/NFATC2/PPP2R2A/PPP2R3A/PPP2R5C/RHOA/PPP3CB/MAPK1/PPP2CB/SOS1/PPP2R5E/SOS2/PPP2R5B/MAPK8/PIK3CA/PTPN11/GSK3B/PPP2R1A/PIK3R1/NFATC1/PPP2R2B/NFATC3/MAP3K14/DLG1/MALT1	1.95401044597673
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	20/1475	85/9376	1.49567298105683	GUK1/NT5E/ENPP1/ADSS2/NME3/CMPK1/AK4/AMPD3/NT5C2/IMPDH1/TK2/UPP1/NT5C/NME7/RRM1/RRM2B/ADK/DCTD/NUDT16/LACC1	1.98341729832806
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/1475	205/9376	1.30232988838363	COX7A1/COL3A1/CAMK2D/PPP1CB/TGFBR2/MT-ND4L/MT-ND2/MT-ND3/ATP5F1E/COL1A2/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/MT-CO2/GAPDH/NDUFA4L2/CTSD/SLC2A1/NDUFB7/SMAD2/VDAC2/NDUFB2/NDUFS4/NDUFC1/MAPK8/PRKCA/COX7A2L/PIK3CA/MPC1/GSK3B/COX7A2/NDUFB1/UQCRC1/PIK3R1/PTPA/PLCB4/PPARA/COL1A1/RAC1/PDK2/UQCRHL	1.89099458402645
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1475	75/9376	1.52558644067797	THBS1/PERP/SFN/CCND1/IGFBP3/CDK6/CCND2/TP53I3/SESN3/SERPINB5/BCL2L1/CD82/ZMAT3/COP1/PPP1R13L/TSC2/DDB2/RRM2B	1.97447018212756
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/1475	55/9376	1.61804622496148	CERS6/SGMS2/ASAH1/KDSR/SGMS1/SPTLC3/PLPP2/SMPD1/PSAP/CERK/SGPP2/ARSA/PLPP1/GALC	1.98614826988428
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	20/1475	86/9376	1.47828143476547	GNAQ/CAMK2D/KCNMA1/ITPR3/KCNMB4/VAMP2/RIMS2/ADCY7/SLC2A1/TRPM4/ATP1B1/ATP1A4/PCLO/KCNN4/PRKCA/ADCY9/ATF4/PLCB4/CREB3/CREB1	1.92515414830753
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/1475	36/9376	1.76572504708098	C1GALT1/B3GNT3/GCNT1/GALNTL6/GALNT3/GALNT6/GALNT5/GALNT13/ST6GALNAC2/ST3GAL1	1.98880078605249
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	22/1475	98/9376	1.42699411968177	GSN/ASAP2/ASAP1/PLA2G4A/PLD1/GAB2/PLPP2/ARF6/MAPK1/DOCK1/PRKCA/PIK3CA/PIK3R1/WASF3/SCIN/ACTR3/PIP5K1A/CFL2/RAC1/RPS6KB2/PLPP1/DNM2	1.83589722514006
Organismal Systems	Digestive system	hsa04970	Salivary secretion	21/1475	93/9376	1.43536358665938	ATP2B4/GNAQ/KCNMA1/ITPR3/GUCY1A1/VAMP2/CALM2/CST3/ADCY7/CALM1/ATP1B1/ADRA1B/ATP1A4/KCNN4/PRKG1/PRKCA/ADCY9/ATP2B1/GUCY1B1/PLCB4/SLC12A2	1.82301406271252
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/1475	93/9376	1.43536358665938	LAMB3/CCND1/CDK6/COL4A5/LAMA3/ITGA2/PTGS2/ITGAV/LAMC2/BCL2L1/PTK2/COL4A6/LAMB2/ITGA6/ITGB1/FHIT/CDKN2B/LAMC1/PIK3CA/PIK3R1/DDB2	1.82301406271252
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1475	32/9376	1.78779661016949	PPP2CB/GABARAPL2/ATG9B/RPTOR/ATG7/PIK3C3/ATG10/ULK2/BECN1	1.92869386696571
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	32/1475	155/9376	1.31233242208857	THBS1/TUBA4A/TUBA1A/ACTB/ITGA2/ATP6AP1/TUBB6/LAMP1/THBS3/ITGAV/ACTG1/ATP6V1F/DYNC1H1/ITGB5/SEC61G/RAB7A/ITGB1/DYNC1LI2/DYNC1I2/DYNC2H1/ATP6V0A1/ATP6V1G1/ATP6V0B/RAB5A/RAB5B/ATP6V1D/PIK3C3/ATP6V1A/STX7/STX18/RAC1/CLEC7A	1.69408237690276
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	26/1475	122/9376	1.35468741317033	CCND1/PLCD1/KAT2B/HIF1A/PFKP/ACTB/ITGAV/SRC/ACTG1/SLC2A1/NCOA1/ATP1B1/ATP1A4/MAPK1/PRKCA/PIK3CA/GSK3B/THRA/TSC2/BAD/PIK3R1/NCOA2/PLCB4/PLCD3/THRB/CREBBP	1.70373310462707
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1475	128/9376	1.34084745762712	GUK1/PDE4D/GUCY1A1/NT5E/ENPP1/ADCY7/ADSS2/NME3/PRPS2/AK4/AMPD3/FHIT/NT5C2/IMPDH1/PDE10A/ADCY9/NT5C/PAPSS1/NME7/PDE8A/GUCY1B1/PDE5A/RRM1/RRM2B/ADK/NUDT16/LACC1	1.67757424773231
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	19/1475	86/9376	1.4043673630272	ITGB6/JUP/GJA1/LMNA/DSG2/DSC2/ITGB4/ACTB/ITGA2/ITGAV/DSP/CTNNA1/ACTG1/ITGB5/ITGA6/ITGB1/SGCE/CDH2/SGCZ	1.62763897945091
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1475	70/9376	1.45293946731235	ACSL3/ADIPOR1/ACSL1/SLC2A1/IRS2/LEPR/JAK2/MAPK8/APPL1/PTPN11/CPT1A/PRKAG2/TNFRSF1A/PPARA/TRADD/PRKAA1	1.64341890427433
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/1475	97/9376	1.37617333566311	GNAQ/CAMK2D/ITPR3/GUCY1A1/PER3/CALM2/GNB1/ADCY7/CALM1/GNB5/PER2/MAPK1/PRKG1/RPS6KA5/PRKCA/ADCY9/GNB2/PER1/GUCY1B1/PLCB4/CREB1	1.6090291252458
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/1475	103/9376	1.35772256047392	LAMB3/COL3A1/GNAQ/COL4A5/LAMA3/COL1A2/LAMC2/PTK2/COL4A6/LAMB2/GNA15/VCL/RAB7A/LAMC1/PRKCA/PIK3CA/RAB5A/RAB5B/PIK3R1/PLCB4/SERPINB10/COL1A1	1.57723145814896
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/1475	76/9376	1.42187332738626	CCND1/CAMK1D/CDK6/CAMK2D/CALM2/CALM1/MAPK1/SHC3/SOS1/SOS2/PRKCA/PIK3CA/PIK3R1/IGF1R/DDB2/BRAF/EGF	1.59546766784556
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1475	98/9376	1.36213075060533	ATP2B4/CAMK1D/GNAQ/CAMK2D/ITPR3/CALM2/ADCY7/CALM1/ATP1B1/ATP1A4/PRKCA/DAGLB/ADCY9/ATF4/ATP2B1/LDLR/PLCB4/CREB3/CREB1/PRKD2/PRKD1	1.55701169999646
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/1475	93/9376	1.3670129396756	GNAQ/CAMK2D/ITPR3/PLA2G4A/CALM2/PLD1/ADCY7/MAP2K4/SRC/MAP3K2/CALM1/MAPK1/SOS1/SOS2/MAPK8/PRKCA/ADCY9/ATF4/PLCB4/MAP3K3	1.53680686839239
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1475	35/9376	1.63455690072639	PFKP/TPI1/SORD/ALDOC/PMM1/HK1/FPGT/GMDS/HK2	1.62498188895386
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1475	99/9376	1.34837185413457	CCND1/ADCY7/PTK2/SRC/ERBB2/MAPK1/SHC3/SOS1/SOS2/MAPK8/PIK3CA/BIK/ADCY9/BAD/PIK3R1/IGF1R/ESR2/BRAF/GPER1/CARM1/RPS6KB2	1.50555801919267
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	30/1475	150/9376	1.27132203389831	WNT5A/CCND1/JUP/WNT2/TGFBR2/DVL1/CTNNA1/GAB1/SMAD2/ERBB2/WNT2B/MET/MAPK1/CDH1/APC/SHC3/FZD6/CDKN2B/SOS1/SOS2/FZD1/PIK3CA/WNT11/GSK3B/PIK3R1/AXIN1/DDB2/BRAF/RPS6KB2/EGF	1.44732007440505
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1475	21/9376	1.81617433414044	BCAT1/ENPP1/DPYD/PPCS/PANK3/CSAD	1.61774960517263
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1475	140/9376	1.27132203389831	CCND1/GNAQ/MYLK/RRAS/ITPR3/CCN2/CALM2/GNB1/ADCY7/MAP1LC3A/MEF2A/SMAD2/CALM1/GNB5/MAPK1/CDH1/ADCY9/GNB2/PRKAG2/PIK3C3/PLCB4/APELA/MEF2D/KLF2/RRAS2/BECN1/RPS6KB2/PRKAA1	1.39748687312188
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1475	101/9376	1.32167142137943	WNT5A/WNT2/GNAQ/EDN1/CAMK2D/DVL1/CALM2/ADCY7/CALM1/WNT2B/MAPK1/FZD6/PRKCA/FZD1/WNT11/ADCY9/GSK3B/PLCB4/CREB3/CREB1/CREBBP	1.40429006490144
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/1475	79/9376	1.36787813773868	VAMP2/CLTB/AP2S1/SLC18A3/ATP6V1F/ATP6V0A1/STXBP1/ATP6V1G1/ATP6V0B/AP2B1/SLC1A6/ATP6V1D/SLC1A1/ATP6V1A/UNC13B/DNM2/SLC6A9	1.41868745025065
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	43/1475	227/9376	1.20411558276712	CCND1/AKAP13/GNAQ/CDK6/PPP3CA/ITPR3/CALM2/GNB1/PTGS2/ITGAV/ADCY7/PPP3CC/PTK2/NFATC2/ARHGEF12/SRC/RHOA/VEGFA/CALM1/GNB5/PPP3CB/ROCK1/MAPK1/SOS1/SOS2/PRKCA/PIK3CA/ADCY9/GNB2/GSK3B/ATF4/TSC2/PIK3R1/TNFRSF1A/NFATC1/NFATC3/PLCB4/CREB3/RAC1/TRADD/CREB1/ARHGEF11/RPS6KB2	1.34506382768079
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	31/1475	158/9376	1.24718300793821	SFN/CCND1/CDK6/YWHAZ/CCND2/CDC25B/YWHAQ/RBL2/STAG1/PPP2R5C/ANAPC16/NIPBL/CDC14B/SMAD2/ATRX/PPP2CB/CDKN2B/PPP2R5E/PPP2R5B/GSK3B/STAG2/RBX1/PDS5A/PPP2R1A/WEE1/CDC16/ANAPC13/CDC27/SMC1A/YWHAH/CREBBP	1.35384648534948
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1475	63/9376	1.41258003766478	ERCC6/CETN2/CUL4A/POLR2I/ERCC1/POLR2L/RBX1/RFC1/CUL4B/DDB2/XPA/POLD2/UVSSA/ERCC3	1.41962716751881
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/1475	17/9376	1.86959122632104	MYH14/PCDH7/PCDH9/LAMP1/PCDH1	1.55047762688481
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1475	53/9376	1.43923249120563	ATP2B4/GNAQ/CLTB/AP2S1/ATP1B1/ATP1A4/PRKCA/ADCY9/AP2B1/ATP2B1/PLCB4/DNM2	1.38546375494
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/1475	59/9376	1.40060902039644	NT5E/ENPP1/NME3/CMPK1/DPYD/NT5C2/TK2/UPP1/NT5C/NME7/RRM1/RRM2B/DCTD	1.33367281712061
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1475	155/9376	1.23031164570804	WNT5A/CCND1/WNT2/GNAQ/CDK6/CAMK2D/ITPR3/RAP1A/DVL1/ADCY7/WNT2B/MAPK1/APC/FZD6/PBX1/CDKN2B/AHR/FZD1/WNT11/ADCY9/GSK3B/ATF4/AXIN1/NCEH1/PDE8A/LDLR/PLCB4/CREB3/BRAF/CREB1	1.24920396537895
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1475	76/9376	1.33823371989295	EZR/GNAQ/MYLK/CAMK2D/ITPR3/ACTB/CALM2/KCNJ15/ADCY7/ACTG1/CALM1/ATP1B1/ATP1A4/PRKCA/ADCY9/PLCB4	1.2791540238102
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	66/1475	368/9376	1.14004421518055	COX7A1/TUBA4A/KLC3/PPP3CA/OPTN/ITPR3/KIF5B/TUBA1A/PINK1/ACTB/MT-ND4L/TUBB6/MT-ND2/RB1CC1/MT-ND3/ATP5F1E/PPP3CC/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/BCL2L1/KLC1/MT-CO2/NDUFA4L2/CHMP2B/ULK1/PFN2/MAP1LC3A/DNAH5/ACTG1/PRKN/NDUFB7/WDR41/ACTR10/PPP3CB/NDUFB2/NDUFS4/RANBP2/ANG/DCTN1/NDUFC1/COX7A2L/COX7A2/NDUFB1/RAB5A/ATF4/SPG11/BAD/UQCRC1/DNAH7/NUP214/TNFRSF1A/EIF2AK3/PIK3C3/MCU/DCTN3/PFN4/ULK2/DNAL1/SETX/RAC1/BECN1/UQCRHL/GPX1/DCTN2	1.18417397477673
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1475	49/9376	1.42699411968177	C1GALT1/B4GALT2/GALNTL6/GALNT3/FUT11/GALNT6/GALNT5/GALNT13/RFNG/B3GLCT/COLGALT1	1.29476086264785
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/1475	71/9376	1.34294581045596	ATP6AP1/MAP2K4/ADAM10/SRC/ATP6V1F/MET/ATP6V0A1/MAPK8/ATP6V1G1/ATP6V0B/PTPN11/ATP6V1D/MAP3K14/ATP6V1A/RAC1	1.25324824414731
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1475	99/9376	1.28416367060435	GNAQ/CAMK2D/PPP1CB/ITPR3/PLA2G4A/CALM2/ADCY7/P2RY2/SRC/TRPV3/CALM1/PRKCH/MAPK8/PRKCA/PIK3CA/ADCY9/PIK3R1/HRH1/NGF/PLCB4	1.22806962722179
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1475	28/9376	1.58915254237288	HACD2/HACD4/ELOVL6/ELOVL1/ELOVL7/ACOT7/HSD17B12	1.34892572606294
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1475	28/9376	1.58915254237288	B3GNT3/B4GALT2/B4GALT4/A4GALT/B3GALT5/B3GNT2/ABO	1.34892572606294
Organismal Systems	Nervous system	hsa04730	Long-term depression	13/1475	60/9376	1.37726553672316	GNAQ/ITPR3/GUCY1A1/PLA2G4A/MAPK1/PPP2CB/PRKG1/PRKCA/PPP2R1A/GUCY1B1/IGF1R/PLCB4/BRAF	1.26662669505203
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/1475	122/9376	1.2504806890803	IGFBP3/GNAQ/ITPR3/SSTR1/ADCY7/MAP2K4/PTK2/IRS2/MAPK1/JAK2/SHC3/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/ADCY9/GSK3B/ATF4/PIK3R1/PLCB4/CREB3/CREB1/CREBBP	1.20317842192775
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1475	77/9376	1.32085406119304	CCND1/CDK6/TGFBR2/GAB2/BCL2L1/CTBP2/MAPK1/SHC3/SOS1/SOS2/PIK3CA/PTPN11/BAD/PIK3R1/DDB2/BRAF	1.22144916486354
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/1475	224/9376	1.16348668280872	CCND1/PPP3CA/TSPO/KAT2B/CCND2/TGFBR2/CD40/ADCY7/PPP3CC/MAP2K4/BCL2L1/NFATC2/SLC2A1/ANAPC16/SMAD2/VDAC2/PPP3CB/MAPK1/CDKN2B/MAPK8/PIK3CA/ADCY9/ATF4/PIK3R1/TNFRSF1A/NFATC1/CDC16/NFATC3/ANAPC13/CDC27/MAP3K14/MAP3K3/DLG1/KAT5/CREB3/ELK4/CREB1/CREBBP/TLN2/LTBR/FOSL1	1.07001287369201
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	15/1475	73/9376	1.30615277455305	MAP1B/MDFIC/KAT2B/SERINC5/APOBEC3C/SERINC3/PDCD6IP/RANBP2/BICD2/CHMP4B/VPS4B/PIN1/NELFB/SUPT5H/CREBBP	1.13456331426603
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	46/1475	254/9376	1.15119711730949	ATP2B4/CAMK1D/GNAQ/PPP3CA/PLCD1/MYLK/CAMK2D/AVPR1A/ITPR3/CALM2/VEGFB/ORAI3/ADCY7/PPP3CC/NFATC2/PHKA1/STIM1/GNA15/NTRK3/VEGFA/ERBB2/CALM1/VDAC2/PPP3CB/ADRA1B/PDGFD/ASPH/MET/ITPKC/PRKCA/ADCY9/PTGFR/ATP2B1/SLN/ITPKB/MST1R/NFATC1/HRH1/NFATC3/NGF/MCU/TNNC2/PLCB4/PLCD3/FGFR3/EGF	1.05549444721933
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1475	14/9376	1.81617433414044	B4GALT2/B4GALT4/B3GNT2/ST3GAL1	1.3203931131664
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1475	62/9376	1.33283761618371	KAT2B/DVL1/ATXN1/CTBP2/RFNG/TLE4/PSENEN/MAML2/TLE1/NUMBL/CIR1/CREBBP/NCOR2	1.13605863828114
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1475	19/9376	1.67279214986619	HPSE/HYAL2/HGSNAT/HYAL1/GNS	1.26832343973359
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1475	137/9376	1.20636397377211	CAPN2/TUBA4A/ITPR3/LMNA/TUBA1A/ACTB/NOL3/SPTAN1/BCL2L1/PARP4/CTSD/ACTG1/CTSZ/MAPK1/MAPK8/PIK3CA/ATF4/BAD/PIK3R1/TNFRSF1A/EIF2AK3/NGF/MAP3K14/CTSF/TRADD/GZMB	1.05128943410605
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1475	57/9376	1.33823371989295	ACSL3/HACD2/HACD4/SCD5/ACSL1/ELOVL6/SCP2/ELOVL1/ACOX1/CPT1A/ELOVL7/HSD17B12	1.10665000783078
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/1475	91/9376	1.25735146209722	PPP3CA/DAPP1/CD81/PPP3CC/NFATC2/BLNK/PPP3CB/MAPK1/SOS1/SOS2/PIK3CA/GSK3B/IFITM1/PIK3R1/NFATC1/NFATC3/RAC1/MALT1	1.06585223335282
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1475	214/9376	1.15844764771107	GNAQ/PPP3CA/ITPR3/CALM2/GNB1/PPP3CC/BCL2L1/PTK2/NFATC2/CUL4A/APOBEC3C/CALM1/GNB5/PPP3CB/FBXW11/MAPK1/ELOB/MAPK8/PRKCA/RNF7/PIK3CA/TAB2/GNB2/BTRC/RBX1/BAD/PIK3R1/TNFRSF1A/WEE1/CUL4B/NFATC1/NFATC3/AP1G1/CFL2/IRAK1/IRAK4/RAC1/TRADD/RPS6KB2	1.01306697153002
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1475	69/9376	1.28974699091132	GNAQ/EDN1/PPP3CA/KCNMA1/ITPR3/GUCY1A1/CALM2/PPP3CC/CALM1/PPP3CB/EDN2/GUCY1B1/PLCB4/CREB1	1.04370854780239
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/1475	275/9376	1.13263235747304	COX7A1/CAV2/TUBA4A/KLC3/PPP3CA/ITPR3/KIF5B/CAV1/TUBA1A/FYN/MT-ND4L/TUBB6/MT-ND2/MT-ND3/ATP5F1E/PPP3CC/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/KLC1/MT-CO2/NDUFA4L2/NDUFB7/VDAC2/PPP3CB/NDUFB2/NDUFS4/MAPK1/NDUFC1/LAMC1/MAPK8/COX7A2L/PIK3CA/GSK3B/COX7A2/NDUFB1/ATF4/BAD/UQCRC1/PIK3R1/EIF2AK3/PRNP/MCU/C5/CREB3/RAC1/CREB1/UQCRHL	0.96452146306624
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1475	133/9376	1.19485153561871	CCND1/CCND2/TGFBR2/RBL2/FOXO3/BNIP3/IRS2/SETD7/MAPK1/CDKN2B/SOS1/SOS2/MAPK8/GABARAPL2/PIK3CA/PRKAG2/STK4/PIK3R1/IGF1R/BRAF/FBXO25/KLF2/CREBBP/PRKAA1/EGF	0.977830983611759
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1475	20/9376	1.58915254237288	EBP/MSMO1/CYP2R1/SC5D/DHCR7	1.13956280317386
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1475	20/9376	1.58915254237288	CYB5R1/CYB5R3/UAP1/GMDS/UAP1L1	1.13956280317386
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	21/1475	110/9376	1.21353466872111	CDC25B/ADCY7/RPS6KA2/CPEB4/ANAPC16/CPEB2/MAPK1/MAPK8/PIK3CA/ADCY9/SPDYA/PIK3R1/CDC16/ANAPC13/IGF1R/CDC27/RPS6KA3/RPS6KA6/SPDYE2/BRAF/STK10	0.973327979054319
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	30/1475	163/9376	1.16992825205365	YWHAZ/TGFBR2/ATP6AP1/YWHAQ/MAP2K4/NFATC2/SRC/MAPK1/JAK2/HSPG2/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/TAB2/IFNAR1/ATF4/BAD/PIK3R1/NFATC1/NFATC3/DDB2/IRAK1/IRAK4/CREB3/BRAF/STAT6/CREB1/CREBBP	0.94558260477214
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/1475	116/9376	1.20556399766219	PFKP/OGDH/PKM/GLUD1/PGK1/GAPDH/TPI1/SUCLA2/PRPS2/ENO1/ALDOC/ACOX1/TALDO1/ME3/ENO2/GPI/DLST/PGLS/HK1/IDNK/MMUT/HK2	0.96252312782151
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1475	70/9376	1.27132203389831	CCND1/CAV1/ACTB/FYN/CD55/CD40/EIF4G1/ABL2/EIF4G3/ACTG1/CXADR/SGCE/RAC1/SGCZ	0.984448898437776
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1475	31/9376	1.43536358665938	PFKP/PRPS2/ALDOC/TALDO1/GPI/PGLS/IDNK	1.04902035155621
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	22/1475	117/9376	1.1952600318702	ACTB/CHD3/MACROH2A1/CDK2AP1/MBD2/H2AC6/ACTG1/BAZ2B/H2AJ/ARID1B/BPTF/MEAF6/RSF1/MORF4L1/BICRAL/BCL7C/PBRM1/SMARCC2/INO80E/KAT5/CHRAC1/MACROH2A2	0.918258299122964
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	6/1475	26/9376	1.46691003911343	LMBRD1/CUBN/AMN/PLB1/TCN2/BTD	1.03004144130923
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1475	37/9376	1.37440219880898	GPI/UAP1/PMM1/HK1/FPGT/GMDS/UAP1L1/HK2	0.985892771510802
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1475	16/9376	1.58915254237288	A4GALT/B3GALT5/ST3GAL1/ABO	1.01903814400327
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	27/1475	149/9376	1.15186895688773	GNAQ/GABRP/ITPR3/MT-ND4L/MT-ND2/GNB1/MT-ND3/PTGS2/ADCY7/MT-ND4/MT-ND5/NDUFA4L2/NDUFB7/GNB5/NDUFB2/NDUFS4/MAPK1/NDUFC1/MAPK8/PRKCA/DAGLB/ADCY9/GNB2/NDUFB1/PLCB4/GABRB1/GABRB3	0.807369801764461
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1475	38/9376	1.33823371989295	GNPDA2/GPI/UAP1/PMM1/HK1/FPGT/UAP1L1/HK2	0.902656227994892
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	19/1475	102/9376	1.18407444333666	ATP2B4/GNAQ/KCNMA1/ITPR3/RAP1A/RAB27B/PRSS3/ADCY7/RHOA/ATP1B1/ATP1A4/RAB3D/PRKCA/ADCY9/ATP2B1/PLCB4/RAC1/PLA2G12A/SLC12A2	0.807608076291752
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/1475	67/9376	1.23337212243865	PFKP/PKM/PGK1/GAPDH/ALDH3B1/TPI1/ENO1/ALDOC/ENO2/GPI/BPGM/HK1/HK2	0.828276766974556
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/1475	156/9376	1.14093003042156	CCND1/CDK6/YWHAZ/CD81/PIAS1/YWHAQ/PPP2R2A/MAPK1/PPP2CB/SOS1/SOS2/PIK3CA/GSK3B/CLDN9/IFNAR1/PPP2R1A/BAD/PIK3R1/TNFRSF1A/PPP2R2B/LDLR/YWHAH/CLDN1/PPARA/BRAF/TRADD/CLDN4/EGF	0.766903997928997
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	53/1475	308/9376	1.09383226942549	COX7A1/TUBA4A/KLC3/GNAQ/KIF5B/TUBA1A/MT-ND4L/TUBB6/CLTB/MT-ND2/RB1CC1/MT-ND3/ATP5F1E/AP2S1/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/KLC1/MT-CO2/NDUFA4L2/ULK1/POLR2I/DNAH5/NDUFB7/VDAC2/ACTR10/NDUFB2/NDUFS4/IFT57/DCTN1/NDUFC1/MAPK8/COX7A2L/POLR2L/AP2B1/COX7A2/NDUFB1/UQCRC1/DNAH7/PIK3C3/DCTN3/ULK2/PLCB4/HTT/DNAL1/CREB3/BECN1/CREB1/CREBBP/UQCRHL/GPX1/DCTN2	0.72345652881149
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	21/1475	115/9376	1.16077229182019	GNAQ/CAMK2D/ITPR3/FYN/GNB1/ACHE/ADCY7/SLC18A3/GNB5/MAPK1/JAK2/PRKCA/KCNQ5/PIK3CA/ADCY9/GNB2/ATF4/PIK3R1/PLCB4/CREB3/CREB1	0.749500277948153
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/1475	181/9376	1.12382058245154	PPP3CA/CAMK2D/ATP6AP1/CALM2/LAMP1/PPP3CC/ARHGEF12/SRC/CTSD/RHOA/CALM1/PPP3CB/RAB7A/RIPK2/MAPK1/JAK2/ATP6V0A1/MAPK8/ATP6V0B/RAB5A/RAB5B/BAD/TNFRSF1A/PIK3C3/NOD2/IRAK1/IRAK4/TRADD/CLEC7A/MALT1/CREB1/CREBBP	0.726769813813697
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	12/1475	62/9376	1.23031164570804	CRYAB/ADCY7/FOXO3/IRS2/PIK3CA/ADCY9/PRKAG2/RPTOR/PIK3R1/IGF1R/RPS6KB2/PRKAA1	0.786111670920476
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1475	17/9376	1.49567298105683	GLUD1/CA5B/CA13/CA3	0.883782913302056
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	46/1475	268/9376	1.09105995446496	COX7A1/TH/TUBA4A/KLC3/CAMK2D/ITPR3/KIF5B/TUBA1A/PINK1/MT-ND4L/CALM2/TUBB6/MT-ND2/MT-ND3/ATP5F1E/MT-ND4/MT-ND5/MT-CYB/MT-ATP8/BCL2L1/KLC1/MT-CO2/NDUFA4L2/UBA1/SLC39A6/PRKN/NDUFB7/SLC39A14/CALM1/VDAC2/NDUFB2/NDUFS4/TXN/UBE2G1/NDUFC1/MAPK8/SLC39A13/COX7A2L/COX7A2/NDUFB1/ATF4/UQCRC1/UBE2J1/EIF2AK3/MCU/UQCRHL	0.653467408738888
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1475	63/9376	1.21078288942696	KMT2C/ASH1L/EHMT1/KMT2E/SETD7/CAMKMT/KMT5B/DLST/EZH1/SETD2/SMYD3/COLGALT1	0.725272890012546
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1475	63/9376	1.21078288942696	WNT5A/WNT2/DVL1/WNT2B/APC/FZD6/BMP2/FZD1/WNT11/GSK3B/AXIN1/DDB2	0.725272890012546
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	14/1475	75/9376	1.18656723163842	BCAT1/PFKP/PKM/PGK1/GAPDH/TPI1/PRPS2/ENO1/ALDOC/TALDO1/ENO2/ASNS/ASL/NAGS	0.700876977261764
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1475	75/9376	1.18656723163842	GNAQ/ITPR3/ADCY7/ATP1B1/ATP1A4/PRKCA/DUOX1/ADCY9/ATF4/TTF1/PLCB4/CREB3/CREB1/GPX1	0.700876977261764
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1475	226/9376	1.09693715314234	ATP2B4/EDN1/CAMK2D/PPP1CB/RRAS/SOX9/RAP1A/PDE4D/CALM2/PLD1/AFDN/SSTR1/ADCY7/TIAM1/RHOA/CNGA1/CALM1/ATP1B1/ROCK1/ATP1A4/MAPK1/ACOX1/EDN2/MAPK8/PIK3CA/PDE10A/ADCY9/BAD/PIK3R1/ATP2B1/NFATC1/PPARA/CREB3/BRAF/RAC1/RRAS2/HTR1B/CREB1/CREBBP	0.637344953157656
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1475	12/9376	1.58915254237288	VKORC1/NQO1/VKORC1L1	0.88232440941335
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	34/1475	196/9376	1.10267727429955	CCND1/CDK6/PPP3CA/HIF1A/ITPR3/CALM2/GNB1/PTGS2/PPP3CC/MAP2K4/NFATC2/SRC/MAP1LC3A/VEGFA/CALM1/GNB5/PPP3CB/MAPK1/JAK2/MAPK8/PIK3CA/GNB2/GSK3B/IFNAR1/PIK3R1/TNFRSF1A/PIK3C3/NFATC1/NFATC3/RAC1/TRADD/BECN1/CREB1/CREBBP	0.627655940770762
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	27/1475	154/9376	1.11447061413163	ATP2B4/GNAQ/CAMK2D/PPP1CB/CALM2/ADCY7/PPP2R2A/PPP2R3A/PPP2R5C/CALM1/ATP1B1/ADRA1B/ATP1A4/MAPK1/PPP2CB/PPP2R5E/PPP2R5B/RPS6KA5/PRKCA/ADCY9/ATF4/PPP2R1A/ATP2B1/PPP2R2B/PLCB4/CREB3/CREB1	0.618845777105196
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	26/1475	148/9376	1.1167017865323	WNT5A/CCND1/WNT2/CDK6/DVL1/NCOA1/ERBB2/WNT2B/MAPK1/APC/SHC3/FZD6/SOS1/SOS2/FZD1/PIK3CA/WNT11/GSK3B/PIK3R1/AXIN1/IGF1R/ESR2/DDB2/BRAF/RPS6KB2/EGF	0.618294220190129
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1475	18/9376	1.41258003766478	LMBRD1/TCN2/MMAA/MMUT	0.756995958310705
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	37/1475	216/9376	1.08886377903327	PPP3CA/CAMK2D/MIB2/RAP1A/CALM2/CD40/ERO1A/PPP3CC/MAP2K4/BCL2L1/PTK2/NFATC2/SRC/RHOA/CALM1/PPP3CB/MAPK1/JAK2/MAPK8/PRKCA/PIK3CA/TAB2/GSK3B/ATF4/BAD/PIK3R1/TNFRSF1A/EIF2AK3/NFATC1/NFATC3/LDLR/PLCB4/MIB1/IRAK1/IRAK4/RAC1/POU2F3	0.570879613543289
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1475	47/9376	1.21722322394519	PKM/IRS2/MAPK1/MAPK8/PIK3CA/PIK3R1/SOCS4/HK1/HK2	0.645027536030342
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1475	65/9376	1.17352803129074	MBOAT2/DGKB/AGPAT2/PLPP2/MBOAT1/LPIN3/DGKA/LCLAT1/AGPAT3/LPL/DGKE/PLPP1	0.60655302378293
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1475	65/9376	1.17352803129074	GNAQ/ITPR3/ADCY7/PBX1/ADCY9/ATF4/NCEH1/PDE8A/LDLR/PLCB4/CREB3/CREB1	0.60655302378293
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1475	89/9376	1.14276137878499	GABRP/TRAK2/GNB1/ADCY7/SRC/GNB5/GPHN/SLC38A1/GABARAPL2/PRKCA/ADCY9/GNB2/GLS/ABAT/GABRB1/GABRB3	0.584667067044609
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1475	144/9376	1.10357815442561	WNT5A/HAND1/ID4/WNT2/ACVR2A/DVL1/MEIS1/ZFHX3/SMAD2/BMPR1A/WNT2B/MAPK1/JAK2/APC/FZD6/FZD1/PIK3CA/WNT11/GSK3B/PIK3R1/AXIN1/IGF1R/PCGF5/SMAD1/FGFR3	0.5411804930871
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1475	36/9376	1.23600753295669	ENPP1/PYGL/PYGB/GPI/HK1/GBE1/HK2	0.612977163079434
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1475	42/9376	1.21078288942696	ACSL3/ACSL1/MAP1LC3A/SLC39A14/VDAC2/ATG7/PRNP/GCLC	0.591516301718977
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	27/1475	157/9376	1.09317499730109	COX7A1/ADIPOR1/MT-CYB/MT-CO2/NDUFA4L2/NDUFB7/IRS2/NDUFB2/NDUFS4/LEPR/NDUFC1/MAPK8/COX7A2L/PIK3CA/GSK3B/COX7A2/PRKAG2/NDUFB1/ATF4/UQCRC1/PIK3R1/TNFRSF1A/EIF2AK3/PPARA/RAC1/PRKAA1/UQCRHL	0.508683821201474
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/1475	90/9376	1.13006403013183	PPP3CA/HIF1A/PPP3CC/NFATC2/PPP3CB/MAPK1/JAK2/PIK3CA/PTPN11/PIK3R1/NFATC1/NFATC3/MAP3K3/BATF/RPS6KB2/EGF	0.535679145662039
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	18/1475	103/9376	1.11086391311502	COL17A1/COL3A1/COL7A1/COL12A1/COL4A5/COL5A1/SLC1A5/PRSS3/COL1A2/COL4A6/ATP1B1/ATP1A4/KCNN4/COL5A2/SLC1A1/COL9A3/COL1A1/COL6A1	0.488809123771376
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1475	73/9376	1.13199907127931	CCND1/CDK6/PDGFD/MET/MAPK1/CDH1/PIK3CA/BAD/PIK3R1/IGF1R/DDB2/BRAF/EGF	0.489171799959445
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1475	31/9376	1.23031164570804	ALDH3B1/DPYD/SMOX/ACOX1/ABAT/CSAD	0.554942147095918
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	20/1475	116/9376	1.09596727060199	GNAQ/PPP3CA/ITPR3/PLA2G4A/PLD1/GNB1/ADCY7/PPP3CC/GNB5/PPP3CB/MAPK1/SLC38A1/PRKCA/ADCY9/GNB2/GLS/SLC1A6/SLC1A1/PLCB4/GRIK2	0.449352603173809
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/1475	68/9376	1.12175473579262	CCND1/JUP/PER2/MAPK1/SOS1/SOS2/PIK3CA/BAD/PIK3R1/BRAF/RPS6KB2/ZBTB16	0.435364235060666
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1475	38/9376	1.17095450490633	NT5E/ENPP1/NT5C2/NT5C/SIRT7/SIRT3/NADK2	0.456232301753722
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1475	26/9376	1.22242503259452	PLAAT2/PLA2G4A/PLB1/ACOX1/PLA2G12A	0.49068767420796
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1475	32/9376	1.19186440677966	BOK/BCL2L1/BIRC6/MAPK8/TNFRSF1A/BECN1	0.469724926291992
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1475	75/9376	1.10181242937853	GSTO2/BCL2L1/ABCC2/ERCC1/ERBB2/MGST1/MAPK1/PIK3CA/BAD/PIK3R1/REV3L/XPA/MSH3	0.382478676045315
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1475	168/9376	1.05943502824859	CAPN2/CAMK2D/PLA2G4A/CYLD/MACROH2A1/GLUD1/PYGL/CHMP2B/H2AC6/CHMP4C/SMPD1/VDAC2/H2AJ/TNFAIP3/JAK2/MAPK8/PYGB/IFNAR1/CHMP3/TNFRSF1A/CHMP1B/CHMP4B/SHARPIN/VPS4B/TRPM7/TRADD/STAT6/MACROH2A2	0.335857519749115
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1475	69/9376	1.10549742078113	PLA2G4A/FYN/MAP2K4/GAB2/MAPK1/SOS1/SOS2/MAPK8/PRKCA/PIK3CA/PIK3R1/RAC1	0.380016232417317
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1475	69/9376	1.10549742078113	TH/PPP3CA/CAMK2D/PPP1CB/CALM2/PPP3CC/CALM1/PPP3CB/PRKCA/ATF4/CREB3/CREB1	0.380016232417317
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	18/1475	106/9376	1.07942436840422	CCND1/FOLR3/ERBB2/PDGFD/MAPK1/SOS1/SOS2/PIK3CA/GSK3B/ATF4/BAD/PIK3R1/IGF1R/CREB3/BRAF/CREB1/CREBBP/EGF	0.355310018256423
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/1475	119/9376	1.06833784361202	EDN1/CYLD/PTGS2/MAP2K4/MAPK1/TAB3/TNFAIP3/RPS6KA5/MAPK8/PIK3CA/TAB2/ATF4/PIK3R1/TNFRSF1A/NOD2/MAP3K14/CREB3/TRADD/RPS6KA4/CREB1	0.324145679179488
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1475	52/9376	1.10018252933507	TSPO/VAPA/SORT1/OSBPL5/VDAC2/NPC2/NCEH1/LDLR/LPL	0.312991936482957
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/1475	103/9376	1.0491492512753	GNAQ/TGFBR2/MAP2K4/PPP2R2A/GNA15/SMAD2/MAPK1/PPP2CB/MAPK8/PIK3CA/PPP2R1A/PIK3R1/TNFRSF1A/PPP2R2B/PLCB4/IRAK1/IRAK4	0.21670354017698
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1475	28/9376	1.13510895883777	ATP6V1F/ATP6V0A1/ATP6V1G1/ATP6V1D/ATP6V1A	0.309345945727075
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1475	78/9376	1.05943502824859	TOB1/PFKP/XRN1/ENO1/ZCCHC7/PAN3/CNOT2/LSM1/ENO2/EXOSC7/LSM4/CNOT4/NUDT16	0.227738062396287
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	33/1475	205/9376	1.02325919801571	GSN/CCND1/CDK6/YWHAZ/KAT2B/CCND2/PKM/YWHAQ/RBL2/UBR4/SRC/RHOA/MAPK1/CDKN2B/RASA2/SP100/PIK3CA/ATF4/BAD/PIK3R1/SCIN/YWHAH/DLG1/CREB3/GTF2E2/RAC1/TRADD/H2BC5/H2BC21/CREB1/CREBBP/LTBR/H2BC12	0.14548021603704
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1475	10/9376	1.27132203389831	BPNT2/PAPSS1	0.370892972599233
Organismal Systems	Sensory system	hsa04744	Phototransduction	5/1475	29/9376	1.09596727060199	CALM2/RGS9/GNB1/CNGA1/CALM1	0.223628236129019
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1475	48/9376	1.05943502824859	ATP1B1/ATP1A4/PIK3CA/PIK3R1/PLCB4/HK1/HK2/TAS1R3	0.178364918980202
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1475	61/9376	1.04206724090025	ATP2B4/ATOX1/CYBRD1/ATP1B1/ATP1A4/MT1E/STEAP1/ATP2B1/TRPM7/MT1G	0.14241578690361
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1475	23/9376	1.10549742078113	GLUD1/GLS/ASL/NAGS	0.218862275553307
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1475	23/9376	1.10549742078113	GLUD1/ATP1B1/ATP1A4/GLS	0.218862275553307
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/1475	112/9376	1.021598062954	LAMB3/LAMA3/CD40/LAMC2/BCL2L1/LAMB2/ITGA6/ITGB1/MAPK1/JAK2/LAMC1/MAPK8/TAB2/BAD/TNFRSF1A/LDLR/IRAK1/IRAK4	0.0993493793427432
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1475	17/9376	1.12175473579262	CYP7B1/SCP2/HSD3B7	0.2170881997193
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1475	17/9376	1.12175473579262	TXNRD2/MARS1/PAPSS1	0.2170881997193
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1475	82/9376	1.00775527077305	GSTO2/NME3/CMPK1/DPYD/MGST1/IMPDH1/TK2/UPP1/NME7/RRM1/RRM2B/TPMT/CES2	0.0304749621755936
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1475	37/9376	1.03080164910673	GLUD1/ADSS2/GLS/ABAT/ASNS/ASL	0.0811082929041088
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1475	37/9376	1.03080164910673	CCND1/CCDC6/MAPK1/CDH1/DDB2/BRAF	0.0811082929041088
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1475	50/9376	1.01705762711864	THBS1/CD81/SDC1/CD40/THBS3/HBB/GYPC/MET	0.0522512314775394
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1475	76/9376	1.00367528991971	ACSL3/SLC27A6/SCD5/FABP5/ACSL1/SCP2/ACOX1/ME3/CPT1A/PPARA/LPL/SLC27A4	0.0138994476687891
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1475	44/9376	1.01127889060092	B4GALT2/DAD1/B4GALNT3/MAN1A2/KRTCAP2/MAGT1/MAN1B1	0.0324000719697579
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	29/1475	187/9376	0.985784464787456	NEK7/ITPR3/ERBIN/GBP2/BCL2L1/MAP1LC3A/TXNIP/RHOA/VDAC2/RIPK2/MAPK1/TAB3/TNFAIP3/TXN/MAPK8/GABARAPL2/SUGT1/TAB2/IFNAR1/PKN2/NOD2/MCU/SHARPIN/PLCB4/TRPM7/IRAK4/PANX1/NLRX1/ANTXR2	-0.0848380173184105
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/1475	142/9376	0.984826927667701	PPP3CA/ITPR3/TGFBR2/FYN/CYLD/PPP3CC/GAB2/NFATC2/BLNK/PPP3CB/MAPK1/MAPK8/PIK3CA/TAB2/IFNAR1/PIK3R1/TNFRSF1A/NFATC1/MAP3K14/RAC1/CREB1/FOSL1	-0.0787160662766041
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	26/1475	168/9376	0.983761097659403	CCND1/CCND2/CLCF1/PIAS1/SOCS6/BCL2L1/STAM/PIAS3/SOCS5/LEPR/JAK2/IL22RA1/SOS1/SOS2/PIK3CA/PTPN11/IFNAR1/PIK3R1/IFNLR1/FHL1/PIAS2/SOCS4/STAT6/CREBBP/PRL/EGF	-0.0917633527614364
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	31/1475	201/9376	0.980372712707648	IGFBP3/JUP/H3-3B/CCND2/TGFBR2/CD40/CDK14/MEIS1/ETV1/BCL2L1/PTK2/KLF3/SUPT3H/PBX3/JMJD1C/MLF1/KDM6A/H3-3A/PER2/MET/AFF1/PBX1/HMGA2/RUNX2/BMP2K/IGF1R/DDB2/SMAD1/ELK4/ZBTB16/GZMB	-0.121533467535668
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1475	32/9376	0.993220338983051	SUCLA2/BCKDHB/ACOX1/ABAT/MMUT	-0.0165980539325793
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1475	65/9376	0.977940026075619	GNAQ/ITPR3/MAPK1/KCNN4/PRKCA/PIK3CA/PIK3R1/ESR2/PLCB4/GPER1	-0.0771088324397969
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1475	19/9376	1.00367528991971	OGDH/BCKDHB/DLST	0.00692852369623764
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1475	59/9376	0.969652398735996	GSTO2/ODC1/LANCL1/MGST1/RRM1/GGT6/RRM2B/GCLC/GPX1	-0.10103060293192
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1475	59/9376	0.969652398735996	PLAAT2/PTGS2/ADCY7/IRS2/PRKG1/PIK3CA/ADCY9/PIK3R1/CIDEC	-0.10103060293192
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/1475	144/9376	0.971148775894539	CCND1/IL17RC/ADIPOR1/SCD5/MAP2K4/FOXO3/TAB3/ACOX1/MAPK8/TAB2/GSK3B/CPT1A/PRKAG2/TNFRSF1A/LPIN3/MAP3K14/PPARA/IRAK1/IRAK4/C5/TRADD/PRKAA1	-0.150743366438079
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	22/1475	144/9376	0.971148775894539	GNAQ/ITPR3/RB1CC1/RORA/ATXN1/ULK1/SPTBN2/VDAC2/PUM2/MAPK8/PRKCA/PIK3CA/BEAN1/PIK3R1/SLC1A6/PIK3C3/ATXN3/MCU/ULK2/PLCB4/KAT5/BECN1	-0.150743366438079
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	16/1475	105/9376	0.968626311541566	CD40/CYLD/PTGS2/BCL2L1/BLNK/TAB3/TNFAIP3/TAB2/PPP1R13L/TNFRSF1A/MAP3K14/IRAK1/IRAK4/TRADD/MALT1/LTBR	-0.139681070942604
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/1475	99/9376	0.963122752953262	ITGB6/EDN1/LMNA/ITGB4/ACTB/ITGA2/ITGAV/ACTG1/ITGB5/ITGA6/ITGB1/PRKAG2/SGCE/SGCZ/PRKAA1	-0.159372332632591
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1475	33/9376	0.963122752953262	BCAT1/OGDH/BCKDHB/DLST/NAGS	-0.0916880857513684
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1475	27/9376	0.941720025109856	AACS/ABAT/OXCT1/HMGCL	-0.131026540848844
NA	NA	hsa04081	Hormone signaling	33/1475	219/9376	0.957845368005572	IGF2/GNAQ/AVPR1A/PTHLH/ADIPOR1/GNB1/ITGAV/SSTR1/ADCY7/SRC/GNA15/RHOA/BMPR1A/GNB5/IRS2/ADRA1B/LEPR/JAK2/PRKG1/APPL1/PIK3CA/ADCY9/GNB2/THRA/PIK3R1/IGF1R/ESR2/PLCB4/SMAD1/UCN2/THRB/GPER1/PRL	-0.272729031404861
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1475	48/9376	0.927005649717514	BCAT1/BCKDHB/AACS/ABAT/OXCT1/HMGCL/MMUT	-0.219056535477586
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	7/1475	49/9376	0.908087167070218	TH/RGS9/GPSM1/ATF4/CDK5R1/CREB3/CREB1	-0.278704397478036
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1475	83/9376	0.919027976312028	L3MBTL4/YAF2/MBD5/SCMH1/KDM2A/PHC3/EZH1/PCGF5/AUTS2/CBX6/FOXK2/CREBBP	-0.320137602765598
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1475	63/9376	0.908087167070218	PLAAT2/PLA2G4A/PTGS2/PLB1/PTGES/PTGR3/ALOXE3/CBR3/PLA2G12A	-0.316258526246855
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/1475	217/9376	0.937380301491838	CCND1/GSTO2/ADCY7/RPS6KA2/SRC/VEGFA/KPNA4/MGST1/MAPK1/JAK2/SOS1/SOS2/AHR/PRKCA/PIK3CA/ADCY9/PAQR8/ATF4/BAD/PIK3R1/ESR2/RPS6KA3/KPNA1/PPARA/PAQR7/KPNA3/KPNA6/RPS6KA6/CREB3/CREB1/RPS6KB2/EGF	-0.403234262979696
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1475	29/9376	0.87677381648159	YAP1/WWTR1/STK3/LATS1	-0.287148461056287
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	11/1475	78/9376	0.896445023902651	CALM2/RHOA/CALM1/ITGB1/MAPK1/MAPK8/CFL2/IRAK1/IRAK4/C5/C1S	-0.39679310842196
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/1475	133/9376	0.908087167070218	PPP3CA/FYN/PPP3CC/NFATC2/PPP3CB/MAPK1/SHC3/SOS1/SOS2/PRKCA/PIK3CA/PTPN11/IFNAR1/PIK3R1/NFATC1/BRAF/RAC1/KLRD1/GZMB	-0.461249717867982
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/1475	160/9376	0.913762711864407	ALCAM/CD99/SLITRK6/SDC1/CD40/ITGAV/SDC4/NRXN3/VTCN1/NECTIN3/PTPRD/ITGA6/ITGB1/CDH1/GLG1/CLDN9/NLGN1/PTPRM/CXADR/CLDN1/NEO1/CDH2/CLDN4	-0.475362005545179
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1475	30/9376	0.84754802259887	PLAAT2/PLA2G4A/PLB1/PLA2G12A	-0.361344474669913
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1475	23/9376	0.829123065585851	B4GALT2/FKTN/POMGNT1	-0.354496957636915
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1475	23/9376	0.829123065585851	RFC1/POLD2/MSH3	-0.354496957636915
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1475	23/9376	0.829123065585851	CTSA/LNPEP/ATP6AP2	-0.354496957636915
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1475	45/9376	0.84754802259887	ABCC2/ABCA5/ABCA12/ABCD3/ABCA2/ABCB8	-0.442910362631069
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1475	94/9376	0.87910566173819	IL17RC/IL17RE/PTGS2/MAPK1/USP25/TAB3/TNFAIP3/MAPK8/TAB2/GSK3B/TRADD/S100A8/FOSL1	-0.508967116977694
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/1475	108/9376	0.88286252354049	IPO7/KPNA4/UPF3A/RANBP2/RANBP17/SENP2/NUP214/THOC2/XPO6/KPNA1/KPNA3/KPNA6/SUMO2/THOC7/XPO7	-0.528999603174982
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1475	24/9376	0.794576271186441	EXT1/HS2ST1/B3GAT3	-0.435356063373202
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/1475	109/9376	0.874762867361219	PPP3CA/HIF1A/TGFBR2/PPP3CC/RORA/NFATC2/SMAD2/PPP3CB/MAPK1/JAK2/MAPK8/AHR/NFATC1/NFATC3/STAT6	-0.568221157667887
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1475	32/9376	0.794576271186441	PFKP/B4GALT2/HK1/HK2	-0.502921034157151
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1475	17/9376	0.747836490528415	GGT6/CSAD	-0.449606513863456
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	14/1475	105/9376	0.84754802259887	ITGB6/LMNA/ITGB4/ACTB/ITGA2/ITGAV/ADCY7/ACTG1/ITGB5/ITGA6/ITGB1/ADCY9/SGCE/SGCZ	-0.678742491464465
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1475	91/9376	0.838234308064816	GABRP/PDE4D/GNB1/ADCY7/GNB5/PRKCA/PDE10A/ADCY9/GNB2/PDE8A/GABRB1/GABRB3	-0.669972195315689
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1475	56/9376	0.794576271186441	B4GALT2/DAD1/MAN1A2/KRTCAP2/MAGT1/DPM3/MAN1B1	-0.666158053991388
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1475	18/9376	0.706290018832392	ACSL3/ACSL1	-0.53889487702272
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1475	34/9376	0.747836490528415	POLR2I/POLR2L/POLR1F/POLR3GL	-0.636417897709098
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1475	191/9376	0.865297719407223	TH/PPP1CB/H3-3B/CALM2/MACROH2A1/GNB1/H2AC6/CALM1/GNB5/CAMKK1/H2AJ/H3-3A/MAPK1/SHC3/SOS1/SOS2/GNB2/ATF4/CREB3/BRAF/SLC29A3/H2BC5/H2BC21/CREB1/MACROH2A2/H2BC12	-0.812629659845663
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1475	43/9376	0.739140717382735	AGPAT2/PLPP2/PLA2G12A/SLC27A4/PLPP1	-0.740748034737671
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/1475	193/9376	0.856330903662071	GNAQ/RAP1A/GNB1/ADCY7/PTK2/TIAM1/SRC/RHOA/FOXO3/GNB5/ROCK1/MAPK1/JAK2/SHC3/SOS1/SOS2/PIK3CA/ADCY9/GNB2/GSK3B/CCL27/BAD/PIK3R1/PLCB4/BRAF/RAC1	-0.871345394179369
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1475	28/9376	0.681065375302663	TH/GPHN/PTS	-0.730233834608786
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/1475	44/9376	0.722342064714946	PARP4/RFC1/POLD2/ADPRS/PNKP	-0.797608329091578
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1475	52/9376	0.733455019556714	PLA2G4A/PTGS2/ADCY7/ADCY9/LDLR/IGF1R	-0.832744293266213
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1475	37/9376	0.687201099404489	GNAQ/HBB/PRKCA/PLCB4	-0.823676185702584
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/1475	83/9376	0.76585664692669	ACSL3/ACSL1/SCP2/PEX2/CROT/ACOX1/ABCD3/GNPAT/HMGCL/PMVK	-0.925728274314119
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1475	21/9376	0.605391444713478	CHSY3/B3GAT3	-0.782158673471184
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1475	12/9376	0.529717514124294	NECTIN4	-0.704302683540154
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1475	30/9376	0.635661016949153	OGDH/SUCLA2/DLST	-0.863562944059937
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1475	30/9376	0.635661016949153	ABCC2/FOLR3/MTHFR	-0.863562944059937
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/1475	99/9376	0.770498202362609	KRT24/DSG1/KRT14/KRT17/KRT19/KRT16/KRT13/KRT10/KRT15/KRT27/C5/C1S	-0.99183750854522
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/1475	47/9376	0.676235124413992	PKM/ACYP2/ME3/HAGH/GRHPR	-0.961394717192445
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1475	115/9376	0.773848194546795	GNAQ/ITPR3/PLA2G4A/GNB1/PTGS2/GNB5/MAPK1/PRKCA/GNB2/PLCB4/GABRB1/GABRB3/BRAF/HTR1B	-1.05429137774079
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/1475	93/9376	0.751857116821578	PPP3CA/PPP3CC/NFATC2/PPP3CB/MAPK1/JAK2/MAPK8/MAML2/NFATC1/NFATC3/STAT6	-1.0390578804888
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1475	31/9376	0.615155822854019	GRHPR/HYI/MMUT	-0.927292466284955
NA	NA	hsa04981	Folate transport and metabolism	3/1475	31/9376	0.615155822854019	ABCC2/FOLR3/MTHFR	-0.927292466284955
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1475	87/9376	0.730644847067991	COX7A1/MT-CYB/MT-CO2/ATP1B1/ASPH/ATP1A4/COX7A2L/COX7A2/UQCRC1/UQCRHL	-1.09053862114459
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1475	103/9376	0.740575942076683	PPP1CB/PPP2R2A/PPP2R3A/PPP2R5C/UPF3A/PPP2CB/PPP2R5E/PPP2R5B/PPP2R1A/PPP2R2B/SMG6/SMG5	-1.143824377795
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1475	88/9376	0.722342064714946	SERPINB2/CLU/CD59/F3/THBD/CD55/TFPI/C5/F12/C1S	-1.1306571670756
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1475	41/9376	0.62015708970649	RAD51B/NBN/BABAM2/POLD2	-1.05312375578995
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1475	15/9376	0.423774011299435	ST3GAL1	-0.964979230736248
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1475	15/9376	0.423774011299435	AK4	-0.964979230736248
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/1475	136/9376	0.747836490528415	CCND1/CDK6/CCND2/BCL2L1/TNFAIP3/MAPK8/RAB9A/PIK3CA/TAB2/GSK3B/IFNAR1/BAD/PIK3R1/IRAK1/IRAK4/TRADD	-1.27984190581777
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1475	43/9376	0.591312573906188	ACSL3/ACSL1/ACOX1/CPT1A	-1.16052764028016
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/1475	195/9376	0.782352020860495	H3-3B/ACTB/MACROH2A1/SRC/H2AC6/CLCN5/ACTG1/VDAC2/H2AJ/H3-3A/MAPK1/PRKCA/PIK3CA/PIK3R1/ATG7/CLCN3/PLCB4/C5/RAC1/CLEC7A/H2BC5/H2BC21/MACROH2A2/H2BC12	-1.32698975078082
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1475	44/9376	0.577873651771957	GTF2F2/TAF13/GTF2E2/ERCC3	-1.21261252962225
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1475	16/9376	0.39728813559322	ALDH3B1	-1.04249126584454
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	18/1475	154/9376	0.742980409421087	BCAT1/EPRS1/VKORC1/ADSS2/NME3/CMPK1/GPHN/AK4/NQO1/PPCS/VKORC1L1/MTHFD1L/NME7/PMM1/PANK3/PTS/GCLC/NADK2	-1.38948750707467
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1475	109/9376	0.699810293888975	CD40/MAP2K4/TOLLIP/MAPK1/MAPK8/PIK3CA/TAB2/IFNAR1/PIK3R1/IRAK1/IRAK4/RAC1	-1.36200932369135
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1475	90/9376	0.635661016949153	ADCY7/ABCC2/SLC2A1/ATP1B1/ATP1A4/HMGCR/ADCY9/NCEH1/LDLR	-1.50055933969015
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/1475	205/9376	0.744188507647788	VIM/CCND1/CDK6/CCND2/CD40/MAP2K4/BLNK/TNFAIP3/MAPK8/PIK3CA/TAB2/IFNAR1/PIK3R1/MAP3K14/DDB2/IRAK1/IRAK4/RAC1/TRADD/SAP30L/SAP30/CIR1/NCOR2/NEDD4	-1.60003415195237
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/1475	50/9376	0.508528813559322	CKB/P4HA2/ODC1/SMOX	-1.50548341505158
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1475	41/9376	0.465117817279868	GABRP/GABRB1/GABRB3	-1.4829739292385
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/1475	68/9376	0.560877367896311	CYP26B1/ALDH1A2/DHRS4L2/CYP2W1/PNPLA4/CYP27C1	-1.57019180879561
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/1475	173/9376	0.698124816302537	CDK6/ACTB/PRSS3/ACTG1/DNAJC3/MAPK1/JAK2/PRKCA/PIK3CA/IFNAR1/PIK3R1/TNFRSF1A/KPNA1/IRAK4/HNRNPUL1/KPNA6/TRADD/NLRX1/CREBBP	-1.73151544740401
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1475	78/9376	0.570465015210778	PTGS2/ITGB1/MAPK1/JAK2/TAB2/IRAK1/IRAK4	-1.64585545005845
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1475	22/9376	0.288936825885978	ALDH3B1	-1.44265160164105
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1475	72/9376	0.529717514124294	CYLD/MAPK8/AZI2/PIN1/TRADD/NLRX1	-1.73073597099419
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1475	46/9376	0.414561532792926	EPRS1/BLVRB/BLVRA	-1.71972880840885
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/1475	180/9376	0.670975517890772	PPP1CB/BCL2L1/SRC/JAK2/SP100/PIK3CA/TAB2/PTPN11/IFNAR1/TSC2/BAD/PIK3R1/TNFRSF1A/IRAK1/IRAK4/C5/TRADD/POU2F3/HCFC2	-1.92577525910774
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1475	36/9376	0.353145009416196	SORD/FGGY	-1.68006220854232
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1475	36/9376	0.353145009416196	RFC1/POLD2	-1.68006220854232
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1475	66/9376	0.481561376476631	SULT2B1/CYP7B1/HSD11B1L/SRD5A1/HSD17B12	-1.8261443066004
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1475	66/9376	0.481561376476631	RORA/SMAD2/NFATC1/NOD2/STAT6	-1.8261443066004
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1475	37/9376	0.343600549702245	TH/ALDH3B1	-1.72846066430928
NA	NA	hsa04082	Neuroactive ligand signaling	21/1475	199/9376	0.670798058087045	GNAQ/GABRP/GNB1/ACHE/ADCY7/P2RY2/SLC18A3/GNB5/ADRA1B/PRKCA/ADCY9/GNB2/SLC1A6/SLC1A1/HRH1/PLCB4/GABRB1/GABRB3/HTR1B/GRIK2/SLC6A9	-2.02805242925795
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/1475	95/9376	0.535293487957181	ATP6AP1/ATP6V1F/VEGFA/ATP6V0A1/ATP6V1G1/ATP6V0B/ATP6V1D/ATP6V1A	-1.96690684702381
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1475	38/9376	0.334558429973238	CD40/BLNK	-1.77588732945213
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	37/1475	323/9376	0.72815658288293	THBS1/VIM/EZR/CCND1/CDK6/CCND2/EFNA5/SERPINB5/DICER1/PTGS2/CDC25B/RHOA/VEGFA/SLC7A1/ERBB2/IRS2/ROCK1/MET/MAPK1/BCL2L2/APC/SOS1/SOS2/RECK/RPS6KA5/FOXP1/PRKCA/PIK3CA/GLS/HMGA2/RPTOR/PIK3R1/RDX/SPRY2/TNC/FGFR3/CREBBP	-2.14814918562578
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1475	39/9376	0.325980008691873	MTHFD1L/MTHFR	-1.82239291951926
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1475	39/9376	0.325980008691873	CD40/GZMB	-1.82239291951926
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1475	50/9376	0.381396610169492	CD40/MAP3K14/LTBR	-1.89491707668386
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1475	41/9376	0.310078544853245	GRHPR/BPGM	-1.91282410268704
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/1475	143/9376	0.577873651771957	H3-3B/CD40/MACROH2A1/H2AC6/H2AJ/H3-3A/RO60/C5/H2BC5/H2BC21/C1S/MACROH2A2/H2BC12	-2.19775703625075
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/1475	54/9376	0.353145009416196	BCAT1/GCLC/LACC1	-2.0596331879063
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/1475	54/9376	0.353145009416196	ERCC1/USP1/REV3L	-2.0596331879063
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1475	44/9376	0.288936825885978	ICA1/GZMB	-2.04262093068358
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/1475	56/9376	0.340532687651332	SAR1B/BNIP3/RAB1B	-2.13855265894736
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1475	45/9376	0.282516007532957	KLRD1/GZMB	-2.08446686427309
Human Diseases	Immune disease	hsa05310	Asthma	1/1475	32/9376	0.19864406779661	CD40	-1.96188997483087
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1475	79/9376	0.402317099334907	GSTO2/ALDH3B1/MGST1/HSD11B1L/CBR3	-2.30490791221001
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1475	70/9376	0.363234866828087	GSTO2/PTGS2/MGST1/HSD11B1L	-2.31040113074499
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/1475	83/9376	0.382928323463345	ZDHHC1/POLR2L/POLR3GL/ZDHHC11B/ZDHHC11	-2.43970495318542
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1475	86/9376	0.369570358691368	ITPR3/PLCB4/SCNN1A/HTR1B/TAS1R3	-2.53757338454184
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1475	54/9376	0.235430006277464	CD40/GZMB	-2.43444629240166
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/1475	42/9376	0.15134786117837	DLST	-2.38155751620259
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1475	73/9376	0.261230554910611	GSTO2/ALDH3B1/MGST1	-2.73778577157349
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1475	46/9376	0.138187177597642	PSMF1	-2.53158003984942
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1475	100/9376	0.317830508474576	CD9/CD59/ITGA2/CD55/ITGA6	-2.96314251763279
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1475	100/9376	0.254264406779661	IL22RA1/CCL27/TNFRSF1A/LTBR	-3.23925486354141
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	24/1475	298/9376	0.511941758616767	IL17RC/TNFRSF12A/TGFBR2/ACVR2A/IL17RE/CLCF1/IL1RN/CD40/IL36RN/IL1RL2/BMPR1A/LEPR/IL22RA1/BMP2/RELL1/IFNAR1/CCL27/TNFRSF1A/TNFRSF21/TNFSF12/NGF/IFNLR1/LTBR/PRL	-3.69934905109529
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/1475	82/9376	0.155039272426623	KLRD1/CREB1	-3.32034134799716
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/1475	238/9376	0.373918245264207	RPS27L/MAPK1/MAPK8/PRKCA/PIK3CA/TAB2/IFNAR1/RSL24D1/PIK3R1/TNFRSF1A/IRAK1/IRAK4/C5/C1S	-4.2270225715832
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	28/1475	370/9376	0.481040769583143	EDN1/LYPD6B/TSPO/AVPR1A/GABRP/PGRMC2/PRSS3/SSTR1/P2RY2/NR3C1/ADRA1B/PGRMC1/LEPR/EDN2/THRA/PTGFR/HRH1/NPFFR2/GABRB1/APELA/C5/UCN2/GABRB3/THRB/HTR1B/GPR83/GRIK2/PRL	-4.40056812902289
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/1475	183/9376	0.2778845975734	NOP10/XRN1/REXO2/SBDS/IMP3/PWP2/EIF6/DROSHA	-4.26230124263144
Genetic Information Processing	Translation	hsa03010	Ribosome	7/1475	222/9376	0.200433653992976	RPS27L/MRPL41/RSL24D1/MRPL51/MRPL20/MRPS18A/MRPL28	-5.20914152646281
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/1475	243/9376	0.183112227104694	SLU7/THOC2/LSM4/WBP11/THOC7/PPIE/PQBP1	-5.5744165844141
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1475	449/9376	0.127415348608962	CAMK2D/CALM2/GNB1/OR2T11/OR2T2/OR2T10/CALM1/PRKG1/OR2G6	-8.1868831180793