category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	94/1565	222/9376	2.53675272716806	RPL39/RPL41/FAU/RPL30/RPS21/RPL28/RPS23/RPS4X/RPL36/RPL37A/RPL19/RPL37/RPL12/RPS15A/RPL22/RPS19/RPS24/RPL32/RPL35A/RPS27A/RPS27/RPL34/RPS15/RPL13/RPL36AL/RPL14/RPS28/RPL21/RPL5/RPLP2/RPL10/RPS8/RPLP1/RPL6/UBA52/RPL29/RPS14/RPS3A/RPS12/RPL11/RPL8/RPS7/RPL24/RPS29/MRPL23/RPL18/RPS13/RPS2/MRPL36/RPL35/RPL38/RPL9/MRPL33/RPS5/MRPL40/MRPS21/RSL24D1/MRPL16/MRPL54/RPSA/RPL7/MRPL41/MRPL13/MRPS23/RPL23/MRPS18C/RPL15/MRPL50/MRPL51/MRPS33/MRPS9/MRPL11/MRPL37/MRPS14/MRPL47/MRPS2/MRPS26/MRPL22/MRPL19/MRPS30/MRPL34/MRPS18A/MRPL14/MRPL21/MRPL24/MRPS34/MRPL9/MRPS15/MRPL20/MRPS22/MRPL1/RPL26L1/MRPL44/MRPL18	10.3720479518493
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	60/1565	138/9376	2.60480622308654	COX7A1/ATP5F1E/MT-ND3/MT-CO3/COX7C/MT-CO1/NDUFA4L2/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/ATP5ME/NDUFC1/NDUFB2/NDUFS5/COX6B1/ATP6V0C/UQCRQ/ATP6V1B2/COX4I1/COX7A2/COX7B/COX6A1/NDUFB6/ATP5PD/UQCRH/NDUFB5/COX11/NDUFS8/COX7A2L/COX17/ATP5MC2/ATP6V1F/NDUFB7/NDUFS6/NDUFS4/PPA2/ATP5PO/ATP5F1D/NDUFA2/NDUFA1/NDUFB3/COX5B/UQCR10/NDUFA12/LHPP/NDUFAB1/ATP5MF/ATP5MC1/NDUFV2/NDUFS7/ATP6AP1/NDUFB4/UQCRHL/NDUFB8/COX8A/ATP5PF/PPA1/COX5A	8.50085589705633
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	91/1565	275/9376	1.98249433633459	COX7A1/KLC3/ATP5F1E/CAV1/FYN/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/MT-CO1/NDUFA4L2/CYBA/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/HSPA1A/NDUFB2/NCF1/NDUFS5/COX6B1/UQCRQ/PRKACB/NCAM2/COX4I1/CAV2/COX7A2/COX7B/COX6A1/VDAC2/NDUFB6/PRKACA/PPIF/ATP5PD/PPP3R1/UQCRH/NDUFB5/EIF2AK3/RAC2/KIF5B/VDAC1/GRIN2B/NDUFS8/COX7A2L/ATP5MC2/PRNP/NDUFB7/NDUFS6/NDUFS4/VDAC3/PIK3R1/ATP5PO/ATP5F1D/PPP3CC/NDUFA2/NDUFA1/HSPA8/CASP3/NDUFB3/COX5B/UQCR10/NDUFA12/NDUFAB1/C5/ITPR1/ATP5MC1/NCAM1/PSMA7/MAPK13/PSMD6/PRKCD/NDUFV2/NDUFS7/PSMB1/PSMC5/NDUFB4/ATF2/UQCRHL/C7/PSMB6/PSMD12/NDUFB8/PSMD9/PSMC6/COX8A/ATP5PF/IL6/COX5A	7.40186799303307
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	73/1565	205/9376	2.13339982856698	COX7A1/COL3A1/CAMK2D/ATP5F1E/COL1A2/MT-ND3/MT-CO3/GAPDH/COX7C/MT-CO1/NDUFA4L2/CYBA/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/NDUFB2/NCF1/MPC2/NDUFS5/COX6B1/COL1A1/UQCRQ/COX4I1/PDK2/COX7A2/COX7B/COX6A1/VDAC2/NDUFB6/PPIF/ATP5PD/UQCRH/PARP1/NDUFB5/RAC2/VDAC1/CD36/NDUFS8/COX7A2L/PPP1CB/ATP5MC2/PTEN/NDUFB7/NDUFS6/NDUFS4/VDAC3/PIK3R1/ATP5PO/ATP5F1D/NDUFA2/NDUFA1/NDUFB3/COX5B/UQCR10/NDUFA12/NDUFAB1/ATP5MC1/MAPK13/PRKCD/NDUFV2/NDUFS7/NDUFB4/UQCRHL/NDUFB8/PLCB2/COX8A/TGFBR1/RELA/ATP5PF/COX5A	7.34414455756564
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	81/1565	238/9376	2.03897226622278	RPL39/RPL41/FAU/RPL30/RPS21/RPL28/RPS23/RPS4X/RPL36/RPL37A/RPL19/RPL37/RPL12/RPS15A/RPL22/RPS19/RPS24/RPL32/RPL35A/RPS27A/RPS27/RPL34/RPS15/RPL13/CXCL8/RPL36AL/RPL14/RPS28/RPL21/RPL5/RPLP2/RPL10/RPS8/IRF9/RPLP1/RPL6/UBA52/RPL29/RPS14/RPS3A/RPS12/RPL11/RPL8/RPS7/RPL24/RPS29/RPL18/RPS13/ADAM17/RPS2/CFD/RPL35/RPL38/RPL9/NFKBIB/JUN/RPS5/MMP1/STAT1/RSL24D1/MX2/RPSA/RPL7/STAT3/RPL23/RPL15/ACE2/PIK3R1/HBEGF/OAS2/C5/MAPK13/RPL26L1/C5AR1/CHUK/C7/CFB/SYK/RELA/IL6/VWF	7.26701985523085
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	88/1565	268/9376	1.96721186400267	COX7A1/KLC3/CAMK2D/ATP5F1E/TH/MT-ND3/MT-CO3/TUBA4A/COX7C/TXN/TUBA1A/MT-CO1/RPS27A/CALM2/NDUFA4L2/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/UBA52/NDUFB2/NDUFS5/COX6B1/UBB/UQCRQ/PRKACB/COX4I1/COX7A2/COX7B/COX6A1/VDAC2/NDUFB6/PRKACA/PPIF/ATP5PD/CALM1/UQCRH/NDUFB5/EIF2AK3/KIF5B/VDAC1/NDUFS8/COX7A2L/ATP5MC2/NDUFB7/NDUFS6/NDUFS4/ERN1/VDAC3/ATP5PO/ATP5F1D/UCHL1/PARK7/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/BCL2L1/NDUFA12/NDUFAB1/MAOB/ITPR1/PRKN/ATP5MC1/PSMA7/PSMD6/NFE2L2/NDUFV2/NDUFS7/PSMB1/GNAI3/ATF6/PSMC5/NDUFB4/UQCRHL/PSMB6/SLC39A10/PSMD12/NDUFB8/PSMD9/PSMC6/COX8A/ATP5PF/COX5A	7.19063081078304
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	78/1565	227/9376	2.05860016044813	COX7A1/MGST1/ATP5F1E/MT-ND3/MT-CO3/SOD2/COX7C/MT-CO1/NDUFA4L2/CYBA/HIF1A/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/NDUFB2/NCF1/SLC26A2/NDUFS5/COX6B1/PTPRJ/UQCRQ/COX4I1/COX7A2/COX7B/COX6A1/MET/VDAC2/NQO1/NDUFB6/ABL2/JUN/PPIF/ATP5PD/UQCRH/NDUFB5/VDAC1/GSTO2/NDUFS8/COX7A2L/ATP5MC2/PTEN/KRAS/NDUFB7/NDUFS6/NDUFS4/PRKD1/VDAC3/PIK3R1/ATP5PO/ATP5F1D/NDUFA2/NDUFA1/NDUFB3/COX5B/ABL1/UQCR10/NDUFA12/NDUFAB1/VEGFA/AHR/ATP5MC1/MAPK13/PRKCD/NFE2L2/NDUFV2/NDUFS7/NDUFB4/CHUK/UQCRHL/PRKD2/NDUFB8/COX8A/RELA/ATP5PF/COX5A	7.22682537039559
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	79/1565	235/9376	2.01401400312691	COX7A1/ATP5F1E/ACTB/MT-ND3/MT-CO3/COX7C/MT-CO1/ACSL3/NDUFA4L2/NDUFB1/ACSL1/NDUFA4/COX6C/UQCRB/NDUFA3/ATP5ME/NDUFC1/NDUFB2/ACTG1/NDUFS5/COX6B1/MAP2K3/UQCRQ/PRKACB/COX4I1/COX7A2/COX7B/COX6A1/NDUFB6/NDUFAF4/PRKACA/RPS6KA2/NDUFAF8/ATP5PD/NDUFAF2/UQCRH/NDUFB5/COX11/NDUFS8/COX7A2L/COX17/ATP5MC2/KRAS/NDUFB7/COA5/NDUFS6/NDUFS4/ATP5PO/ATP5F1D/NDUFA2/NDUFA1/DPF3/NDUFB3/COX5B/UQCR10/NDUFA12/NDUFAB1/ATP5MF/ATP5MC1/ADCY3/MAPK13/NDUFV2/NDUFS7/AKT1S1/ZNF516/ARID1B/NDUFAF1/NDUFB4/ATF2/UQCRHL/COX18/NDUFAF6/NDUFB8/COX8A/COX14/ATP5PF/SLC25A29/COX5A/PRKAA2	7.0464523486313
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	57/1565	157/9376	2.17509615188946	COX7A1/MT-CO3/COX7C/MT-CO1/CXCL8/NDUFA4L2/NDUFB1/ADIPOR2/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/NDUFB2/NDUFS5/COX6B1/UQCRQ/COX4I1/SOCS3/COX7A2/COX7B/COX6A1/NDUFB6/BCL2L11/JUN/UQCRH/NDUFB5/EIF2AK3/NDUFS8/COX7A2L/FAS/NDUFB7/NDUFS6/NDUFS4/ERN1/PIK3R1/BID/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/NDUFA12/NDUFAB1/MAPK13/NDUFV2/NDUFS7/LEPR/NDUFB4/UQCRHL/NDUFB8/COX8A/RELA/IL6/COX5A/PRKAA2	6.64616031732472
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	104/1565	388/9376	1.60584960969665	COX7A1/WNT5A/WNT2/KLC3/ATP5F1E/DKK1/MT-ND3/MT-CO3/TUBA4A/GAPDH/COX7C/TUBA1A/MT-CO1/CALM2/NDUFA4L2/NDUFB1/NDUFA4/FZD6/COX6C/UQCRB/NDUFA3/NDUFC1/DKK2/WNT10A/LPL/NDUFB2/NDUFS5/COX6B1/APBB1/UQCRQ/BACE1/COX4I1/ADAM17/COX7A2/COX7B/COX6A1/VDAC2/WNT6/NDUFB6/PPIF/ATP5PD/PPP3R1/CALM1/UQCRH/NDUFB5/FZD1/WNT11/EIF2AK3/KIF5B/VDAC1/GRIN2B/NDUFS8/COX7A2L/ATP5MC2/PSEN1/FAS/KRAS/NDUFB7/NDUFS6/NDUFS4/ERN1/VDAC3/PIK3R1/BID/ATP5PO/ATP5F1D/PTGS2/PPP3CC/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/NDUFA12/LRP5/NDUFAB1/ITPR1/ATP5MC1/PSMA7/PSMD6/NDUFV2/NDUFS7/RB1CC1/PSMB1/ATF6/PSMC5/NDUFB4/CHUK/UQCRHL/PSMB6/SLC39A10/PSMD12/CAPN2/NDUFB8/PLCB2/PSMD9/PSMC6/COX8A/CDK5R1/RELA/ATP5PF/IL6/COX5A	5.45555142170181
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	86/1565	308/9376	1.67282685365752	COX7A1/KLC3/ATP5F1E/MT-ND3/MT-CO3/TUBA4A/SOD2/COX7C/TUBA1A/MT-CO1/TGM2/POLR2L/NDUFA4L2/NDUFB1/NDUFA4/POLR2I/COX6C/UQCRB/POLR2J3/NDUFA3/AP2S1/IFT57/NDUFC1/NDUFB2/GPX1/NDUFS5/COX6B1/UQCRQ/DNAH5/COX4I1/COX7A2/COX7B/COX6A1/VDAC2/NDUFB6/PPIF/POLR2G/ATP5PD/DCTN3/UQCRH/NDUFB5/KIF5B/VDAC1/GRIN2B/NDUFS8/COX7A2L/ATP5MC2/NDUFB7/NDUFS6/NDUFS4/ERN1/VDAC3/ATP5PO/ATP5F1D/DNAH7/ACTR10/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/NDUFA12/NDUFAB1/ITPR1/AP2A1/ATP5MC1/PSMA7/DCTN2/PSMD6/NDUFV2/NDUFS7/RB1CC1/PSMB1/PSMC5/NDUFB4/UQCRHL/PSMB6/PSMD12/NDUFB8/PLCB2/PSMD9/PSMC6/COX8A/ATP5PF/COX5A	5.37418248664713
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	97/1565	368/9376	1.57916377274621	COX7A1/KLC3/ATP5F1E/ACTB/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/MT-CO1/NDUFA4L2/NDUFB1/NDUFA4/COX6C/UQCRB/NDUFA3/NDUFC1/PFN2/NDUFB2/GPX1/ACTG1/NDUFS5/COX6B1/MAP2K3/OPTN/UQCRQ/DNAH5/COX4I1/COX7A2/COX7B/COX6A1/MAP1LC3A/NDUFB6/TANK/ATP5PD/DCTN3/PPP3R1/UQCRH/NDUFB5/EIF2AK3/PFN4/KIF5B/VDAC1/GRIN2B/NDUFS8/COX7A2L/ATP5MC2/NDUFB7/NDUFS6/NDUFS4/ERN1/BID/NUP214/ATP5PO/ATP5F1D/DNAH7/PPP3CC/ACTR10/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/BCL2L1/NDUFA12/POM121C/NDUFAB1/PRKN/ANXA7/ATP5MC1/PSMA7/MAPK13/DCTN2/PSMD6/NDUFV2/NDUFS7/VCP/RB1CC1/PSMB1/UBQLN1/NUP37/ATF6/PSMC5/NDUFB4/SQSTM1/UQCRHL/PSMB6/PSMD12/RANBP2/NDUFB8/PSMD9/PSMC6/COX8A/ATP5PF/ANG/COX5A	5.07341746161498
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	120/1565	480/9376	1.49776357827476	COX7A1/WNT5A/WNT2/KLC3/CAMK2D/ATP5F1E/DKK1/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/MT-CO1/RPS27A/CALM2/NDUFA4L2/NDUFB1/NDUFA4/FZD6/COX6C/UQCRB/NDUFA3/IFT57/NDUFC1/UBA52/DKK2/WNT10A/NDUFB2/GPX1/NDUFS5/COX6B1/MAP2K3/OPTN/UBB/UQCRQ/DNAH5/COX4I1/SPTBN2/COX7A2/COX7B/COX6A1/VDAC2/MAP1LC3A/WNT6/NDUFB6/PPIF/TANK/ATP5PD/DCTN3/PPP3R1/CALM1/UQCRH/NDUFB5/FZD1/WNT11/EIF2AK3/KIF5B/VDAC1/GRIN2B/NDUFS8/COX7A2L/ATP5MC2/PSEN1/PRNP/FAS/KRAS/NDUFB7/NDUFS6/NDUFS4/ERN1/VDAC3/BID/ATP5PO/ATP5F1D/DNAH7/UCHL1/PTGS2/PPP3CC/ACTR10/PARK7/NDUFA2/NDUFA1/CASP3/NDUFB3/COX5B/UQCR10/BCL2L1/NDUFA12/LRP5/NDUFAB1/ITPR1/PRKN/ATP5MC1/PSMA7/MAPK13/DCTN2/PSMD6/NDUFV2/NDUFS7/VCP/RB1CC1/PSMB1/ATF6/PSMC5/NDUFB4/SQSTM1/UQCRHL/PSMB6/PSMD12/CAPN2/NDUFB8/PLCB2/PSMD9/PSMC6/COX8A/CDK5R1/RELA/ATP5PF/IL6/COX5A	5.01113193999384
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	28/1565	70/9376	2.39642172523962	CCND1/CD40/ACTB/CAV1/FYN/ACTG1/CXADR/HLA-E/CD55/ABL2/HLA-A/SGCB/RAC2/PRF1/BID/HLA-B/HLA-DPB1/CASP3/ABL1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-F/ICAM1/LAMA2/HLA-DMA/HLA-DMB/SNTA1	5.24896386504201
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1565	75/9376	2.15677955271565	THBS1/CCND1/CCND2/SFN/CDK6/SERPINB5/CD82/TP53I3/CDKN2A/SESN3/DDB2/PERP/CCND3/GADD45G/GADD45B/PTEN/FAS/BID/ZMAT3/RRM2B/ZNF385A/PMAIP1/CASP3/BCL2L1/CCNG1/CDKN1A/CHEK1	4.50200427600124
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	56/1565	205/9376	1.63658069040754	VIM/CCND1/CCND2/CDK6/CD40/IRF9/CD44/MAP2K3/HLA-E/SAP30/IRF7/HES1/DDB2/BCL2L11/NFKBIB/JUN/STAT1/CCND3/HLA-A/GADD45G/RUNX3/STAT3/GADD45B/FAS/PIK3R1/BID/HLA-B/HLA-DPB1/OAS2/MYC/CASP3/HLA-DQA2/HLA-DRB5/NFKBIE/USP7/HLA-DRA/CD58/MAPK13/HLA-F/PSMD6/CDKN1B/CDKN1A/ICAM1/PSMC5/B2M/CHUK/BLNK/HLA-DMA/PSMD12/HLA-DMB/PSMC6/SYK/RELA/IL6/CD3D/CD247	4.12488205404
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	45/1565	157/9376	1.71718117254431	CCND1/CCND2/CDK6/CXCL8/CALM2/ZFP36L2/CDKN2A/RRAS/ETS1/MAP2K3/HLA-E/VDAC2/RASSF5/PPP3R1/CCND3/CALM1/NFATC2/HLA-A/GADD45G/NBN/VDAC1/PPP1CB/GADD45B/PTEN/KRAS/NFATC3/VDAC3/PIK3R1/HLA-B/MYC/PPP3CC/MAPKAPK2/ITPR1/RBBP4/MAPK13/HLA-F/HIPK2/CDKN1A/CHEK1/SQSTM1/CAPN2/TGFBR1/RELA/MYBL2/IL6	4.05626470789838
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	61/1565	233/9376	1.568473446777	VIM/DCN/THBS1/COL3A1/PDLIM1/MYH14/COL1A2/PDLIM4/ACTB/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/TRIM55/TNNT1/ANK3/ITGB4/MYL9/ZYX/VCAN/ACTG1/FBLN2/ANKRD2/COL1A1/COL9A3/COL5A2/THBS3/SPTBN2/TNNC2/ENO1/ITGA1/TPM2/ANK2/MYL5/LMNA/TMOD3/SDC3/CAPZA1/NID2/SGCB/MYL11/ITGA6/ENO2/MYH15/ITGB8/MYL4/TNNC1/COL6A2/PLEC/DIAPH3/SPTBN1/CAPZA2/FMNL3/ATP1B1/COL6A3/SDC2/LAMA2/NEBL/SDC1/SNTA1	3.93308447763177
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	54/1565	203/9376	1.59367947244999	THBS1/EMP1/CCND1/CCND2/EMP2/MYLK/LAMB3/COL1A2/ACTB/CAV1/FYN/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/MYL9/ZYX/ACTG1/MYL12B/COL1A1/COL9A3/THBS3/CAV2/MET/ITGA1/PDGFA/RAP1A/JUN/MYL5/CCND3/MYL11/ITGA6/RAC2/PPP1CB/PTEN/PIK3R1/ITGB8/COL6A2/PDGFD/CRK/VEGFA/RAP1B/COL6A3/BIRC3/LAMA2/PIP5K1B/RHOA/CAPN2/VTN/VWF	3.82766433106619
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/1565	116/9376	1.7559986779773	GAPDH/PRPS2/PFKP/ACAT2/ALDOC/SDSL/ENO1/ECHS1/TALDO1/PGK1/ME3/TPI1/TKT/ACOX1/SUCLG2/ESD/GPI/ENO2/SUCLA2/PFKM/TKFC/PGAM4/SUCLG1/PGAM1/IDH3A/DLD/IDNK/MDH1/GLUD1/FH/GOT1/PKM/PGLS/MDH2	3.66719520046245
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/1565	109/9376	1.70387783216578	HSP90AB1/HIF1A/HSP90AA1/RORA/NFKBIB/JUN/STAT1/PPP3R1/IL4R/NFATC2/RARA/STAT3/NFATC3/HLA-DPB1/PPP3CC/HLA-DQA2/HLA-DRB5/NFKBIE/HLA-DRA/AHR/IFNGR1/MAPK13/IL2RG/CHUK/HLA-DMA/HLA-DMB/TGFBR1/RELA/IL6/CD3D/CD247	3.30849471703864
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	55/1565	224/9376	1.47101780009128	CCND1/CCND2/CD40/CDKN2A/KAT2B/ETS1/HLA-E/PRKACB/VDAC2/FDPS/PRKACA/JUN/PPP3R1/CCND3/NFATC2/HLA-A/VDAC1/PTEN/KRAS/NFATC3/VDAC3/PIK3R1/HLA-B/FOSL1/HLA-DPB1/MYC/PPP3CC/ANAPC16/BCL2L1/CDKN2C/HLA-DQA2/HLA-DRB5/HLA-DRA/EGR2/ADCY3/HLA-F/CDC26/CDKN1A/CHEK1/ICAM1/PTTG1/IL2RG/ATF2/B2M/CHUK/HLA-DMA/HLA-DMB/RAN/TGFBR1/RELA/ANAPC11/IL6/ZFP36/ANAPC15/CD3D	3.19369040420752
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1565	45/9376	2.13015264465744	GZMB/HLA-E/KLRC1/HLA-A/PRF1/FAS/HLA-B/HLA-DPB1/KLRD1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-F/HLA-DMA/HLA-DMB/IL6	3.40148655027571
NA	NA	hsa04382	Cornified envelope formation	53/1565	217/9376	1.46325289674769	KRT6A/S100A8/S100A16/KRT5/SPRR3/S100A6/S100A14/DSG1/S100A4/EVPL/PPL/S100A10/KRT24/COL7A1/S100A9/LAMB3/KRT17/KRT16/PKP1/COL4A5/S100A3/COL4A6/TMEM79/KRT14/ITGB4/LAMC2/S100A12/ABCA12/DST/DSG3/PPP2CA/CLDN3/KRT6C/SPRR1B/CASP14/S100A11/ITGA6/KRT13/S100A2/PPP2R2B/PPP2R5C/CLDN9/KRT10/PLEC/CLDN1/ABHD5/KRT27/KRT86/KDSR/KRT78/OCLN/S100A5/PKP3	3.09039129145656
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/1565	89/9376	1.75019564202893	THBS1/LAMB3/COL1A2/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/CD44/COL1A1/COL9A3/THBS3/ITGA1/ITGA6/CD36/ITGB8/COL6A2/CD47/COL6A3/LAMA2/SDC1/VTN/VWF	3.18288764001161
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	41/1565	160/9376	1.53520766773163	SLITRK6/ALCAM/CD40/NECTIN3/CADM1/VTCN1/CD99/VCAN/PTPRM/CXADR/HLA-E/NCAM2/CLDN3/CDH2/SDC3/HLA-A/ITGA6/SELL/HLA-B/CLDN9/PTPRC/HLA-DPB1/NLGN1/ITGB8/NRXN3/PTPRD/CLDN1/HLA-DQA2/HLA-DRB5/NLGN4X/HLA-DRA/CD58/NCAM1/HLA-F/ICAM1/NEO1/SDC2/OCLN/HLA-DMA/HLA-DMB/SDC1	3.05633232912255
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	50/1565	204/9376	1.46839566497526	LUM/DCN/THBS1/WNT5A/CCND1/WNT2/CAMK2D/COL1A2/ACTB/CAV1/ITGA2/ITGB5/ANK3/HIF1A/FZD6/RRAS/WNT10A/ACTG1/CD44/COL1A1/PRKACB/CAV2/MET/WNT6/PRKACA/MSN/ANK2/EZR/TWIST1/HPSE/FZD1/STAT3/WNT11/PPP1CB/FAS/KRAS/PIK3R1/HBEGF/MYC/CASP3/HSPB2/ITPR1/VEGFA/MAPK13/CDKN1A/SDC2/RHOA/SDC1/VTN/PDCD4	3.02750882615876
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	11/1565	27/9376	2.44079990533665	HACD4/ELOVL6/HSD17B12/SCP2/ACOX1/HACD1/SCD5/HACD3/ELOVL7/ELOVL5/HACD2	3.35577213644517
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/1565	20/9376	2.69597444089457	EBP/MSMO1/SC5D/CYP2R1/DHCR7/TM7SF2/CYP51A1/HSD17B7/NSDHL	3.39843278258485
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	37/1565	142/9376	1.56104936327229	HSP90AB1/EDN1/MGST1/ACTB/CAV1/TXN/CALM2/THBD/CYBA/HSP90AA1/ACTG1/NCF1/BMPR1A/CAV2/NQO1/PDGFA/JUN/CALM1/GSTP1/ACVR2A/RAC2/GSTO2/PIK3R1/SUMO3/SUMO1/VEGFA/SUMO2/MAPK13/NFE2L2/ICAM1/SDC2/SQSTM1/CHUK/RHOA/SDC1/RELA/PRKAA2	3.01536438606872
Human Diseases	Immune disease	hsa05330	Allograft rejection	14/1565	39/9376	2.1506348816253	CD40/GZMB/HLA-E/HLA-A/PRF1/FAS/HLA-B/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-F/HLA-DMA/HLA-DMB	3.22296544997779
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/1565	87/9376	1.7215673313503	COX7A1/MT-CO3/COX7C/MT-CO1/COX6C/UQCRB/COX6B1/UQCRQ/COX4I1/COX7A2/COX7B/COX6A1/TPM2/CACNG4/UQCRH/COX7A2L/MYL4/TNNC1/COX5B/UQCR10/ATP1B1/CACNA2D3/UQCRHL/COX8A/COX5A	3.0265057098235
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/1565	44/9376	2.04240487946558	HSPD1/GZMB/ICA1/HLA-E/HLA-A/PRF1/FAS/HLA-B/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-F/HLA-DMA/HLA-DMB	3.10216503868321
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	50/1565	216/9376	1.38681812803219	HSP90AB1/CAMK2D/CD40/SOD2/HSPD1/CXCL8/CALM2/CYBA/HSP90AA1/HSPA1A/NCF1/MAP2K3/IRF7/CCL3L1/RAP1A/JUN/CXCL2/MMP1/TANK/PPP3R1/CALM1/NFATC2/STAT3/EIF2AK3/CD36/FAS/KRAS/MIB2/NFATC3/ERN1/PIK3R1/BID/PPP3CC/HSPA8/CASP3/BCL2L1/ITPR1/OLR1/MAPK13/NFE2L2/RAP1B/CASP6/ICAM1/ATF6/CHUK/RHOA/PLCB2/LDLR/RELA/IL6	2.57439656841211
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/1565	112/9376	1.55125513464172	LAMB3/CD40/LAMC2/HSPA1A/MAP2K3/NFKBIB/PPIF/STAT1/ALOX5/ITGA6/STAT3/SOCS1/HLA-DPB1/HSPA8/CASP3/BCL2L1/HLA-DQA2/HLA-DRB5/HLA-DRA/IFNGR1/MAPK13/BIRC3/GNAI3/LAMA2/CHUK/HLA-DMA/HLA-DMB/LDLR/RELA	2.62695041956632
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/1565	93/9376	1.61049847126318	NFKBIB/JUN/STAT1/PPP3R1/IL4R/NFATC2/RUNX3/NOTCH2/NFATC3/HLA-DPB1/PPP3CC/HLA-DQA2/HLA-DRB5/NFKBIE/HLA-DRA/IFNGR1/MAPK13/IL2RG/CHUK/HLA-DMA/HLA-DMB/JAG1/RELA/CD3D/CD247	2.64832554764058
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/1565	137/9376	1.48683099741144	ACTB/TUBA4A/TUBA1A/NGF/GZMB/CTSW/ACTG1/CTSS/BCL2L11/JUN/LMNA/GADD45G/PARP1/EIF2AK3/PRF1/GADD45B/FAS/KRAS/ERN1/PIK3R1/BID/PMAIP1/CASP3/BCL2L1/BCL2A1/ITPR1/CTSC/PARP3/CASP6/BIRC3/CHUK/NOL3/CAPN2/RELA	2.56930411829281
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	21/1565	75/9376	1.67749520766773	GAPDH/PRPS2/PFKP/ALDOC/SDSL/ENO1/TALDO1/PGK1/TPI1/TKT/BCAT2/ENO2/BCAT1/PFKM/PGAM4/CTH/PGAM1/IDH3A/GOT1/PKM/NAGS	2.63670490607316
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1565	57/9376	1.78680567232778	ACSL3/ACSL1/ACAT2/HACD4/ECHS1/ELOVL6/HSD17B12/SCP2/ACOX1/HACD1/MCAT/ACSF3/SCD5/HACD3/ELOVL7/ELOVL5/HACD2	2.66691850251748
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	72/1565	333/9376	1.29536309472412	THBS1/WNT5A/CCND1/CCND2/WNT2/LAMB3/CDK6/COL1A2/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/PATJ/TNC/FZD6/IRF9/WNT10A/DLG3/COL1A1/COL9A3/ATP6V0C/HLA-E/CRB3/PRKACB/ATP6V1B2/THBS3/ITGA1/WNT6/PPP2CA/HES1/PRKACA/HES4/STAT1/CCND3/HLA-A/MX2/FZD1/NOTCH2/ITGA6/WNT11/PPP2R2B/PPP2R5C/PSEN1/RFNG/PTEN/FAS/ATP6V1F/KRAS/PIK3R1/HLA-B/ITGB8/PTGS2/COL6A2/CASP3/IRF1/VEGFA/HLA-F/CDKN1B/CDKN1A/COL6A3/ATP6AP1/LAMA2/CHUK/PKM/DLG2/JAG1/RELA/VTN/VWF	2.45647060367252
NA	NA	hsa04518	Integrin signaling	37/1565	154/9376	1.43940915314717	THBS1/CCND1/CCND2/LAMB3/COL1A2/ACTB/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/ACTG1/COL1A1/COL9A3/THBS3/ITGAD/MET/ITGA1/FERMT1/PDGFA/CCND3/ITGAX/ITGA6/RAC2/PIK3R1/ITGB8/COL6A2/PDGFD/VEGFA/ICAM1/COL6A3/LAMA2/VTN/VWF	2.46097040488202
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1565	28/9376	2.13966225467823	HACD4/ECHS1/ELOVL6/HSD17B12/HACD1/HACD3/ELOVL7/ELOVL5/HACD2/THEM4	2.7032444426652
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	27/1565	105/9376	1.54055682336832	RPS27A/HIF1A/TOMM7/UBA52/RRAS/OPTN/UBB/MAP1LC3A/JUN/SMURF2/GABARAPL2/BNIP3/USP15/MARCHF5/EIF2AK3/RABGEF1/KRAS/FUNDC1/BCL2L1/PRKN/SAMM50/VCP/SQSTM1/RELA/TOMM20/RAB5B/ATG9B	2.4932291908344
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	27/1565	105/9376	1.54055682336832	CALM2/IRF9/RRAS/BCL3/CYLD/JUN/CLEC7A/STAT1/PPP3R1/CALM1/NFATC2/KRAS/NFATC3/PIK3R1/PTGS2/PPP3CC/MAPKAPK2/IRF1/ITPR1/EGR2/MAPK13/PRKCD/CHUK/RHOA/SYK/RELA/IL6	2.4932291908344
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	37/1565	155/9376	1.43012264248171	THBS1/ACTB/TUBA4A/ITGA2/ITGB5/TUBA1A/CYBA/ACTG1/NCF1/FCGR3B/ATP6V0C/HLA-E/ATP6V1B2/THBS3/CTSS/CLEC7A/DYNC2H1/HLA-A/SEC61B/CORO1A/CD36/ATP6V1F/HLA-B/HLA-DPB1/PLA2R1/SEC22B/EEA1/HLA-DQA2/HLA-DRB5/HLA-DRA/OLR1/HLA-F/ATP6AP1/SEC61G/HLA-DMA/HLA-DMB/RAB5B	2.41689973206892
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/1565	101/9376	1.54225160535223	CCND1/COL3A1/EDN1/F3/COL1A2/COL4A5/COL4A6/PLCD1/CXCL8/THBD/COL1A1/JUN/STAT1/STAT3/KRAS/PIK3R1/CASP3/VEGFA/MAPK13/PRKCD/CDKN1B/ICAM1/PLCB2/TGFBR1/RELA/IL6	2.4524155682208
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	45/1565	196/9376	1.37549716372172	CCND1/CDK6/RPS27A/CXCL8/CALM2/HIF1A/IRF9/UBA52/HLA-E/UBB/CLEC2B/IRF7/MAP1LC3A/JUN/CXCL2/STAT1/PPP3R1/CALM1/NFATC2/HLA-A/STAT3/FAS/KRAS/NFATC3/PIK3R1/BID/HLA-B/MYC/PTGS2/PPP3CC/MAPKAPK2/CASP3/ITPR1/VEGFA/IFNGR1/MAPK13/HLA-F/PREX1/CDKN1A/ICAM1/CHUK/SYK/RELA/IL6/ZFP36	2.37795069861793
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/1565	93/9376	1.54607853241266	CCND1/LAMB3/CDK6/COL4A5/ITGA2/COL4A6/LAMC2/DDB2/GADD45G/FHIT/ITGA6/GADD45B/PTEN/PIK3R1/MYC/PTGS2/CASP3/BCL2L1/CDKN1B/CDKN1A/BIRC3/LAMA2/CHUK/RELA	2.36887362783102
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/1565	194/9376	1.35879582358947	MYH14/KLC3/ACTB/TUBA4A/TUBA1A/DYNLL1/TNNT1/MYL9/ACTG1/MYL12B/MYL6/DYNC2LI1/KIFC3/DNAH5/TNNC2/MYO16/KIF9/KIF13A/TPM2/MYL5/DYNC2H1/KIF1C/DCTN3/CAPZA1/MYL11/KIF5B/KIFAP3/MYL6B/ACTA2/MYO15B/MYO5A/MYH15/DNAH7/ACTR10/MYL4/MYO5B/TNNC1/CAPZA2/DNAI4/KIF22/TUBD1/DCTN2/DYNLT3/DYNLT1	2.26031564039337
NA	NA	hsa04517	IgSF CAM signaling	64/1565	299/9376	1.28236614059645	SLITRK6/SLIT2/MYH14/MYLK/MBP/ACTB/FYN/TUBA4A/NECTIN3/CADM1/TUBA1A/DYNLL1/KIRREL3/ANK3/LMO7/PALS2/MAGI2/MYL9/NTRK3/MAP2/ACTG1/MYL12B/MYL6/EPB41L2/IL1RAPL2/CXADR/NCAM2/SPTBN2/CD2AP/MSN/ANK2/RAP1A/EZR/CDH2/PLXNA2/CADM2/RAPGEF6/ARPC3/ITGAX/KCNQ3/CD96/CD48/MYL6B/EPB41L1/PIK3R1/NLGN1/ROBO2/PTPRD/ABL1/NLGN4X/SPTBN1/NRP2/NCAM1/MAPK13/LRFN4/RAP1B/CADM4/IL1RAPL1/ICAM1/CASK/CSK/RHOA/PPFIA3/CLMP	2.22109193205043
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	39/1565	170/9376	1.37441834241684	CCND1/MYH14/ACTB/TUBA4A/TUBA1A/YBX3/PATJ/NEDD4L/MYL9/ACTG1/MYL12B/MYL6/DLG3/CRB3/PRKACB/PPP2CA/CLDN3/PRKACA/MSN/RAP1A/EZR/JUN/RAPGEF6/ARPC3/RAB13/PPP2R2B/MYL6B/RAP2C/CLDN9/CGN/ARHGAP17/CLDN1/WHAMM/MARVELD3/OCLN/DLG2/RHOA/EPB41L4B/PRKAA2	2.205137028378
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	54/1565	248/9376	1.30450376172318	HSP90AB1/S100A10/KLC3/ACTB/TUBA4A/GAPDH/TXN/TUBA1A/DYNLL1/AHNAK2/CXCL8/MYL9/HSP90AA1/PFN2/RRAS/ACTG1/MYL12B/MAP2K3/DYNC2LI1/PIK3C2G/CASP4/JUN/MYL5/ANXA2/DYNC2H1/AHNAK/DCTN3/BRK1/ARPC3/NAIP/VPS11/MYL11/PFN4/KIF5B/RAB9A/WASF3/PTPRC/MYC/CYTH4/ACTR10/NCKAP1L/RIPK2/CASP3/MAPK13/DCTN2/DYNLT3/MLKL/BIRC3/CHUK/RHOA/RELA/IL6/DYNLT1/RAB5B	2.17530509501866
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	42/1565	187/9376	1.34558439117732	HSP90AB1/TXNIP/GBP2/TXN/CXCL8/CYBA/NAMPT/HSP90AA1/IRF9/IRF7/VDAC2/MAP1LC3A/CASP4/NFKBIB/JUN/CXCL2/STAT1/TANK/NEK7/NAIP/GABARAPL2/ANTXR1/DNM1L/VDAC1/TRIP6/CARD16/VDAC3/OAS2/RIPK2/BCL2L1/ERBIN/ITPR1/NOD2/MAPK13/PRKCD/BIRC3/CHUK/RHOA/PLCB2/RELA/IL6/CARD6	2.13663474515645
Organismal Systems	Immune system	hsa04611	Platelet activation	30/1565	126/9376	1.42644150311882	COL3A1/MYLK/COL1A2/ACTB/FYN/ITGA2/PLA2G4A/GUCY1A1/ACTG1/MYL12B/COL1A1/PRKACB/PRKACA/RAP1A/PPP1CB/PIK3R1/F2R/ITPR1/GUCY1B1/STIM1/ADCY3/MAPK13/RAP1B/GNAI3/RHOA/PLCB2/SYK/VWF/RASGRP2/ORAI1	2.15706564458725
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1565	31/9376	1.93259816551582	PRPS2/PFKP/ALDOC/TALDO1/TKT/GPI/PFKM/RBKS/IDNK/PGLS	2.32795853835321
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/1565	31/9376	1.93259816551582	SRP14/SEC11C/SEC61B/SPCS1/SRP9/IMMP2L/GET3/IMMP1L/SEC61G/OXA1L	2.32795853835321
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/1565	142/9376	1.39228726994555	FYN/CYBA/JUND/IRF9/NCF1/FCGR3B/CAMK4/SOCS3/CYLD/JUN/JUNB/STAT1/PPP3R1/NFATC2/FOSL2/SOCS1/PIK3R1/LILRB4/FOSL1/PPP3CC/TYROBP/ITPR1/IFNGR1/SIRPA/MAPK13/LILRA5/TEC1/SQSTM1/CHUK/BLNK/SYK/TGFBR1/RELA	2.10835113688182
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1565	73/9376	1.55931550614907	MAP1B/MDFIC/APOBEC3C/CHMP4A/KAT2B/BST2/PPIA/PIN1/MX2/SAMHD1/APOBEC3A/PSIP1/APOBEC3F/CCNT2/CCNT1/CHMP4B/RANBP2/RAN/VPS4B	2.14731752948748
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	20/1565	78/9376	1.5361677725895	TOB1/HSPD1/BTG1/PFKP/LSM5/EXOSC7/ENO1/NUDT16/C1D/ENO2/DCPS/PABPC1/PFKM/DHX36/PATL1/TENT4B/LSM4/EXOSC8/BTG3/DDX6	2.12834842790703
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1565	50/9376	1.67749520766773	THBS1/CD40/CD81/GYPC/CXCL8/THBS3/HBB/MET/CD36/KLRB1/ICAM1/SDC2/SDC1/IL6	2.14997304171717
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1565	154/9376	1.36160325297705	CCND1/MYLK/CAMK2D/ACTB/CAMK1D/PLA2G4A/GUCY1A1/CALM2/MYL9/ACTG1/MYL6/PRKACB/CAMK4/PRKACA/JUN/CACNG4/PPP3R1/CALM1/NFATC2/MYL6B/PPP1CB/KRAS/NFATC3/OXTR/PTGS2/PPP3CC/ITPR1/GUCY1B1/ADCY3/CDKN1A/CACNA2D3/GNAI3/RHOA/PLCB2/PRKAA2	2.02520793550139
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1565	104/9376	1.44015728680265	PLAAT2/AGPAT2/DGKB/PLA2G4A/ETNK2/MBOAT2/CHAT/MBOAT7/ACHE/CHPT1/LPGAT1/DGKD/MBOAT1/AGPAT3/TAFAZZIN/SAMD8/GPCPD1/SGMS1/LPCAT2/CDS1/GPAT3/PEMT/AGPAT5/PLB1/SGMS2	2.02035340730376
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1565	12/9376	2.49627263045793	NQO1/GGCX/COQ3/COQ4/COQ5	2.32145432208522
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1565	85/9376	1.48014283029506	ENPP1/ADSS2/GUK1/DCTPP1/NUDT16/NME3/DCK/NME7/TYMS/IMPDH1/NME1/HPRT1/RRM2B/AK4/NT5M/AK3/UPP1/TK1/GMPS/RRM1/CTPS1	1.99038995494318
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	22/1565	90/9376	1.46447994320199	HIF1A/MAP2K3/EML4/NFKBIB/JUN/STAT1/PPP3R1/NFATC2/STAT3/PTEN/KRAS/NFATC3/PIK3R1/BATF/PPP3CC/NFKBIE/IFNGR1/MAPK13/CHUK/RELA/CD3D/CD247	1.98181618412858
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	17/1565	66/9376	1.543150353374	RORA/JUN/STAT1/IL4R/STAT3/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/IFNGR1/NOD2/IL2RG/IL18R1/HLA-DMA/HLA-DMB/RELA/IL6	1.98201384544744
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1565	34/9376	1.76207479797031	NR1D1/RORA/PER3/NPAS2/RORB/NR1D2/DBP/CRY2/FBXL3/PRKAA2	1.99253801955261
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1565	17/9376	2.11448975756437	TXNRD2/KYAT3/TXNRD1/PSTK/CTH/MARS1	2.05861583394732
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/1565	93/9376	1.4172386547116	SNAI2/ACTB/FYN/NECTIN3/LMO7/MYL9/ACTG1/MYL12B/PTPRM/PTPRJ/RASIP1/MET/RAP1A/MYL5/SMURF2/MYL11/RAC2/ARHGAP29/WASF3/RAP1B/RHOA/TGFBR1	1.80996978821191
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/1565	93/9376	1.4172386547116	KCNN4/LYZ/ATP2B4/CST3/KCNMA1/ATP2B1/GUCY1A1/CALM2/ADRA1B/BST1/PRKACB/ADRB2/PRKACA/CALM1/VAMP2/SLC12A2/CST2/ITPR1/GUCY1B1/ADCY3/ATP1B1/PLCB2	1.80996978821191
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1565	83/9376	1.44362754532507	L3MBTL4/PHF19/PCGF5/UBE2D1/CBX6/CBX4/KDM2A/MBD6/SCMH1/USP7/RBBP4/EPOP/TFDP1/OGT/SCML1/YAF2/FBRS/UBE2D2/FOXK1/EZH2	1.81705917944537
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/1565	54/9376	1.55323630339605	CD40/GZMB/HLA-E/HLA-A/PRF1/FAS/HLA-B/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-F/HLA-DMA/HLA-DMB	1.82491437282283
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	23/1565	99/9376	1.39186110304321	DSG1/KRT24/KRT17/KRT16/KRT14/FCGR3B/CFD/KRT13/HLA-DPB1/KRT10/C5/HLA-DQA2/HLA-DRB5/HLA-DRA/FPR1/KRT27/PTAFR/ICAM1/C5AR1/HLA-DMA/CFH/CFB/HLA-DMB	1.75442766055861
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1565	59/9376	1.52314940163535	ENPP1/DPYD/DCTPP1/NME3/DCK/NME7/TYMS/NUDT2/NME1/RRM2B/NT5M/UPP1/TK1/RRM1/CTPS1	1.80427686806321
Organismal Systems	Endocrine system	hsa04924	Renin secretion	17/1565	69/9376	1.47605685974904	EDN1/KCNMA1/GUCY1A1/CALM2/EDN2/PRKACB/PDE3A/ADRB2/PRKACA/PPP3R1/CALM1/PPP3CC/ITPR1/GUCY1B1/GNAI3/PLCB2/ORAI1	1.776511430389
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	27/1565	120/9376	1.34798722044728	CAMK2D/CALM2/NGF/NTRK3/CAMK4/RAP1A/NFKBIB/JUN/RPS6KA2/NTF4/CALM1/SORT1/PSEN1/KRAS/PIK3R1/MAPKAPK2/RIPK2/ABL1/CRK/NFKBIE/MAPK13/PRKCD/RAP1B/ARHGDIA/RHOA/PRDM4/RELA	1.71724292358641
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1565	115/9376	1.354499236005	PDE4D/NACA/JUND/MAFB/PRKACB/PTHLH/PRKACA/AKAP13/OXSR1/STK39/PDE4B/WNK3/MMP16/HBEGF/LRP5/ITPR1/MMP24/ADCY3/RUNX2/CDKN1A/GNAI3/ATF2/SLC12A3/RHOA/PLCB2/PDE4A	1.71208282998799
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/1565	250/9376	1.2221750798722	OSBPL3/OSBPL1A/AP2S1/CTSW/IDS/OSBPL5/ATP6V0C/BLOC1S2/ATP6V1B2/LITAF/CTSS/BORCS5/AP1G1/OSBPL6/SORT1/SUMF1/VPS29/VPS11/NCOA7/AP1S3/AP5Z1/AP1M2/HYAL3/ATP6V1F/HYAL1/MANBA/DMXL2/LAMTOR4/SNAPIN/LAPTM4B/AP3M2/AP2A1/ASAH1/BORCS7/AP1M1/LAMTOR5/CTSC/MCOLN1/LAMTOR2/AKT1S1/BLOC1S5/HYAL2/ATP6AP1/NPC1/FUCA1/AP1S1/AP3S2/SLC11A1/VPS26B/GPR155/AP1S2	1.59372948459757
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1565	46/9376	1.56288373385192	PSMB8/PSMB10/PSME4/PSMA7/PSMB9/PSMD6/PSMB1/PSMC5/PSMB6/PSMD12/PSMD9/PSMC6	1.71295629696991
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	14/1565	56/9376	1.49776357827476	HSPD1/CXCL8/HSPA1A/CLK1/CXCL2/NAIP/BNIP3/HSPA8/SEC22B/CASP3/VCP/RELA/IL6/RAB1B	1.67224021487306
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	9/1565	32/9376	1.68498402555911	BCKDHB/ECHS1/ACOX1/SUCLG2/ABAT/SUCLA2/SUCLG1/ECHDC1/DLD	1.73731475444065
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	32/1565	149/9376	1.28666938267899	GABRP/MT-ND3/NDUFA4L2/NDUFB1/NDUFA4/NDUFA3/NDUFC1/NDUFB2/NDUFS5/PRKACB/NDUFB6/PRKACA/NDUFB5/NDUFS8/NDUFB7/NDUFS6/NDUFS4/PTGS2/NDUFA2/NDUFA1/NDUFB3/NDUFA12/NDUFAB1/ITPR1/ADCY3/MAPK13/NDUFV2/NDUFS7/GNAI3/NDUFB4/NDUFB8/PLCB2	1.57882383925825
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/1565	155/9376	1.27551478924044	WNT5A/CCND1/WNT2/CAMK2D/CDK6/PBX1/FZD6/CDKN2A/WNT10A/PRKACB/WNT6/HSD3B1/PRKACA/RAP1A/NR4A1/FZD1/WNT11/KMT2A/CDKN2C/ITPR1/AHR/ADCY3/NCEH1/CDKN1B/RAP1B/CDKN1A/GNAI3/ATF2/FH/RBBP5/PLCB2/LDLR/ORAI1	1.54814360958588
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1565	82/9376	1.38817112132783	HSP90AB1/HSP90AA1/HSPA1A/HLA-E/CTSS/KLRC1/HLA-A/HLA-B/HLA-DPB1/HSPA8/KLRD1/HLA-DQA2/HLA-DRB5/HLA-DRA/KLRC3/HLA-F/B2M/HLA-DMA/HLA-DMB	1.58022273034273
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/1565	77/9376	1.40050620306211	CCND1/CDK6/CDKN2A/DDB2/STAT1/GADD45G/STAT3/RAC2/GADD45B/KRAS/PIK3R1/BCL2L1/VEGFA/RALGDS/CDKN1A/CHUK/TGFBR1/RELA	1.57952307860682
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/1565	77/9376	1.40050620306211	CCND1/CDK6/CDKN2A/DDB2/GADD45G/CTBP1/GADD45B/KRAS/PIK3R1/MYC/ABL1/CRK/BCL2L1/CDKN1B/CDKN1A/CHUK/TGFBR1/RELA	1.57952307860682
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1565	67/9376	1.43069953745649	CAMK2D/CALM2/PRKACB/CAMK4/PRKACA/RAP1A/RPS6KA2/PPP3R1/CALM1/GRIN2B/PPP1CB/KRAS/PPP3CC/ITPR1/RAP1B/PLCB2	1.5836156383358
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/1565	119/9376	1.3089698499208	EDN1/MAP2K3/BCL3/SOCS3/CYLD/ADAM17/JUN/CXCL2/JUNB/DNM1L/FAS/PIK3R1/PTGS2/CASP3/IRF1/NOD2/MAPK13/ICAM1/MLKL/BIRC3/IL18R1/ATF2/CHUK/JAG1/RELA/IL6	1.5182522764826
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	36/1565	173/9376	1.24669338307263	CDK6/ACTB/CXCL8/IRF9/ACTG1/PRSS3/IRF7/SOCS3/FDPS/NFKBIB/STAT1/CCND3/MX2/HNRNPUL1/TPSB2/DNAJB1/VDAC1/FAS/PIK3R1/BID/HLA-DPB1/TPSAB1/OAS2/CASP3/HLA-DQA2/HLA-DRB5/HLA-DRA/IFNGR1/ICAM1/DNAJC3/CHUK/HLA-DMA/HLA-DMB/RELA/KPNA6/IL6	1.46590333060731
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	38/1565	184/9376	1.23728295596611	WNT5A/SLIT2/CAMK2D/FYN/ABLIM3/NGEF/EPHB4/DPYSL2/MYL9/RRAS/MYL12B/RGS3/MET/EFNA5/SEMA3C/MYL5/EPHA2/PLXNA2/PPP3R1/NFATC2/EPHA4/RHOD/RAC2/CFL1/EPHA1/KRAS/NFATC3/PIK3R1/ABLIM1/PPP3CC/ROBO2/ABL1/PLXNB1/TRPC1/SEMA4F/NEO1/GNAI3/RHOA	1.45498976347193
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	35/1565	168/9376	1.24813631522897	HSP90AB1/CAMK2D/FTH1/FTL/HMGB1/H2AJ/PLA2G4A/MACROH2A1/HSP90AA1/IRF9/CHMP4A/CYLD/VDAC2/H2AZ1/PPIA/STAT1/H2AZ2/PARP1/H2AC20/STAT3/DNM1L/VDAC1/MACROH2A2/FAS/VDAC3/BID/IFNGR1/H2AC8/MLKL/BIRC3/GLUD1/SQSTM1/CHMP4B/CAPN2/VPS4B	1.45261928160563
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1565	48/9376	1.49776357827476	BCKDHB/OXCT1/ACAT2/ECHS1/IVD/BCAT2/ACSF3/MCCC1/BCAT1/ABAT/DLD/HMGCL	1.54752956926251
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	50/1565	250/9376	1.19821086261981	EHD2/ASAP2/CAV1/ARF5/NEDD4L/AGAP1/AP2S1/CHMP4A/WASHC3/EPN3/HSPA1A/FOLR3/HLA-E/CAV2/SH3KBP1/ARAP2/ARPC3/HLA-A/CAPZA1/ZFYVE16/SMURF2/VPS29/KIF5B/STAM/HLA-B/EHD1/CYTH4/HSPA8/BIN1/RAB11FIP4/EEA1/AP2A1/CAPZA2/HLA-F/RAB11FIP1/RAB22A/IL2RG/ASAP1/RAB11FIP3/CHMP4B/PIP5K1B/VPS26B/RHOA/RAB4A/TGFBR1/LDLR/CBLC/VTA1/VPS4B/RAB5B	1.42182685882868
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	30/1565	142/9376	1.2657156999505	FBXO2/RPS27A/NEDD4L/UBA52/ELOB/UBB/UBE2E3/SOCS3/RNF7/DDB2/FANCL/UBE2D1/UBE2B/SMURF2/PIAS2/SOCS1/UBE2M/NHLRC1/ANAPC16/PRKN/UBE2S/CDC26/STUB1/BIRC3/VHL/UBE2D2/ANAPC11/CBLC/UBE2R2/ANAPC15	1.42809119999164
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	70/1565	362/9376	1.15849116551639	THBS1/HSP90AB1/CCND1/EREG/CCND2/LAMB3/CDK6/COL1A2/AREG/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/NGF/TNC/MAGI2/HSP90AA1/COL1A1/COL9A3/YWHAZ/THBS3/MET/ITGA1/PRL/PPP2CA/EFNA5/PDGFA/BCL2L11/EPHA2/IL4R/NTF4/CCND3/GHR/NR4A1/ITGA6/PPP2R2B/PPP2R5C/PTEN/KRAS/PIK3R1/MYC/ITGB8/F2R/COL6A2/PDGFD/BCL2L1/VEGFA/OSMR/PRLR/CDKN1B/CDKN1A/COL6A3/IL2RG/YWHAH/LAMA2/ATF2/CHUK/KITLG/SGK3/SYK/YWHAB/RELA/IL6/VTN/VWF/THEM4/PRKAA2	1.37654387319979
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/1565	116/9376	1.29117549851272	ACTB/CYBA/CD99/MYL9/ACTG1/MYL12B/NCF1/CLDN3/MSN/RAP1A/EZR/MYL5/RASSF5/MYL11/RAC2/THY1/PIK3R1/CLDN9/CLDN1/MAPK13/RAP1B/ICAM1/GNAI3/OCLN/RHOA	1.41243288082863
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1565	44/9376	1.49776357827476	DYNLL1/DYNC2LI1/PRKACB/PRKACA/DYNC2H1/VAMP2/ADCY3/DCTN2/ARHGDIA/STX4/RAB5B	1.48132918453477
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	12/1565	49/9376	1.4671969746365	TH/PRKACB/GPSM1/PRKACA/JUN/RGS9/GRIN2B/MAOB/GNAI3/ATF2/CDK5R1/RELA	1.4676299426973
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	43/1565	214/9376	1.20380997880027	CALM2/APOBEC3C/ELOB/MAP2K3/HLA-E/BST2/RNF7/JUN/AP1G1/PPP3R1/CALM1/NFATC2/HLA-A/SAMHD1/APOBEC3A/RAC2/AP1S3/CFL1/AP1M2/FAS/KRAS/NFATC3/PIK3R1/BID/HLA-B/APOBEC3F/PPP3CC/CASP3/CRK/BCL2L1/ITPR1/AP1M1/MAPK13/HLA-F/CHEK1/GNAI3/AP1S1/B2M/CHUK/RELA/CD3D/CD247/AP1S2	1.3499779563507
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	27/1565	128/9376	1.26373801916933	ENPP1/PDE4D/PRPS2/GUCY1A1/ADSS2/GUK1/PDE3A/NUDT16/NME3/DCK/FHIT/PDE4B/NME7/IMPDH1/NUDT2/NME1/HPRT1/RRM2B/PAICS/AK4/NT5M/AK3/GUCY1B1/ADCY3/GMPS/RRM1/PDE4A	1.34475542373703
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1565	30/9376	1.59761448349308	SUCLG2/SUCLA2/SUCLG1/IDH3A/DLD/MDH1/FH/MDH2	1.46743321005421
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	29/1565	139/9376	1.24993219481922	HSP90AB1/KRT24/KRT17/KRT16/FKBP5/KRT14/CALM2/HSP90AA1/HSPA1A/PRKACB/PRKACA/JUN/CALM1/EBAG9/RARA/KRT13/KRAS/PIK3R1/HBEGF/KRT10/HSPA8/ITPR1/ADCY3/KRT27/PRKCD/GABBR1/GNAI3/ATF2/PLCB2	1.32878164863253
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	41/1565	205/9376	1.19821086261981	CCND1/CCND2/CDK6/CDKN2A/IRF9/KAT2B/GSN/HLA-E/YWHAZ/PRKACB/H2BC12/IRF7/PRKACA/JUN/CCND3/HLA-A/H4C3/STAT3/KRAS/VDAC3/PIK3R1/HLA-B/MAPKAPK2/PMAIP1/CASP3/SCIN/USP7/EGR2/HLA-F/CDKN1B/GTF2B/CDKN1A/CHEK1/YWHAH/ATF2/PKM/RHOA/SYK/YWHAB/RELA/H2BC11	1.28435631563503
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	36/1565	178/9376	1.21167390602003	WNT5A/CCND1/CCND2/WNT2/CAMK2D/DKK1/ROR2/LGR5/PRICKLE1/FZD6/CTNNBIP1/DKK2/WNT10A/PRKACB/WNT6/PRKACA/JUN/CACYBP/PPP3R1/CCND3/NFATC2/FZD1/SFRP2/WNT11/RAC2/CTBP1/PSEN1/NFATC3/FOSL1/MCC/CBY1/MYC/PPP3CC/LRP5/RHOA/PLCB2	1.27620403289064
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1565	71/9376	1.35009674661387	CCND1/CCND2/TH/SOCS3/PRL/STAT1/STAT3/KRAS/SOCS1/PIK3R1/SOCS6/IRF1/PRLR/MAPK13/SOCS5/RELA	1.32540483588076
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1565	21/9376	1.71172980374258	ENPP1/DPYD/BCAT2/BCAT1/PPCS/VNN2	1.46147837627331
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	32/1565	157/9376	1.22110661158707	WNT5A/CCND1/CCND2/WNT2/SNAI2/ACTB/AREG/PATJ/FZD6/WNT10A/ACTG1/DLG3/BMPR1A/YWHAZ/WNT6/PPP2CA/CCND3/FZD1/WNT11/PPP2R2B/BMP2/PPP1CB/SMAD7/MYC/YAP1/YWHAH/BIRC3/CCN2/DLG2/YWHAB/TGFBR1/TP53BP2	1.25054446435318
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	40/1565	201/9376	1.19224961454707	CCND2/CD40/H3-3B/SPINT1/ETV1/PBX1/H3-3A/CXCL8/HMGA2/MLF1/MEIS1/GZMB/CDK14/PBX3/DUSP6/NR4A3/MET/DDB2/PDGFA/BCL6/GADD45G/RARA/ZBTB16/GADD45B/MYC/SUPT3H/KMT2A/CCNT2/BCL2L1/CDKN2C/BCL2A1/CCNT1/RUNX2/CDKN1B/CDKN1A/BIRC3/BCL11B/KLF3/RELA/IL6	1.233246694873
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1565	51/9376	1.40965983837625	ACTB/ACTG1/ATP6V0C/PRKACB/ATP6V1B2/PRKACA/SEC61B/ATP6V1F/SLC12A2/ADCY3/ATP6AP1/SEC61G	1.31302666959285
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1565	41/9376	1.46123275929245	THBS1/CCND1/CXCL8/CDKN2A/MMP1/KRAS/HBEGF/MYC/VEGFA/CDKN1A	1.32478195272086
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	18/1565	83/9376	1.29926479079256	CROT/SOD2/ACSL3/ACSL1/PEX2/ECI2/PMVK/SCP2/MVK/ACOX1/NUDT12/DECR2/NUDT7/PEX16/HMGCL/ABCD3/NUDT19/PEX11A	1.22576210815757
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	49/1565	253/9376	1.16032277210219	ACTB/H3-3B/CAST/PLCD1/RPS27A/H3-3A/CXCL8/MYL9/PFN2/UBA52/ACTG1/MYL12B/CD44/UBB/SEPTIN7/MAP1LC3A/CASP4/CAPNS1/NFKBIB/JUN/MYL5/UBE2D1/ARPC3/GLMN/NAIP/U2AF1/BNIP3/MYL11/SEPTIN6/PFN4/VDAC1/FNBP1/PIK3R1/CYTH4/RIPK2/CRK/BCL2L1/ITPR1/MAPK13/PRKCD/AKT1S1/TNIP1/SQSTM1/CHUK/RHOA/CAPN2/PLCB2/RELA/UBE2D2	1.15711394338614
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1565	170/9376	1.19821086261981	WNT5A/CCND1/WNT2/CDK6/MGST1/ACTB/FZD6/CDKN2A/WNT10A/ACTG1/TXNRD2/MET/NQO1/WNT6/DDB2/GSTP1/GADD45G/TXNRD1/FZD1/WNT11/GSTO2/GADD45B/PTEN/KRAS/PIK3R1/MYC/DPF3/BCL2L1/LRP5/NFE2L2/ARID1B/CDKN1A/PHF10/TGFBR1	1.16736298165404
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1565	78/9376	1.30574260670107	CYBA/MARCKSL1/NCF1/FCGR3B/NFKBIB/JUN/STAT1/HLA-DPB1/PTGS2/HLA-DQA2/HLA-DRB5/HLA-DRA/IFNGR1/MAPK13/HLA-DMA/HLA-DMB/RELA	1.21366264364165
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1565	42/9376	1.42644150311882	FTH1/FTL/ACSL3/ACSL1/VDAC2/MAP1LC3A/CP/SAT2/PRNP/VDAC3	1.23976594514988
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	45/1565	232/9376	1.16205794866145	TMSB4X/MYH14/MYLK/RGCC/ACTB/ITGA2/ITGB5/ITGB6/ITGB4/MYL9/CYRIB/PFN2/RRAS/GSN/ACTG1/MYL12B/ITGAD/ITGA1/PDGFA/MSN/EZR/MYL5/BRK1/ARPC3/ITGAX/MYL11/ITGA6/PFN4/RAC2/CFL1/PPP1CB/SPATA13/KRAS/PIK3R1/ITGB8/F2R/NCKAP1L/PDGFD/DIAPH3/CRK/SCIN/C5/C7/PIP5K1B/RHOA	1.11875685982125
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/1565	100/9376	1.2581214057508	ITGA2/CD59/CD9/CD44/CD55/ITGA1/CD7/IL4R/ITGA6/CD36/HLA-DPB1/HLA-DQA2/HLA-DRB5/CD37/HLA-DRA/ANPEP/KITLG/HLA-DMA/HLA-DMB/IL6/CD3D	1.16153724974363
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	27/1565	133/9376	1.21622907108026	FYN/GZMB/FCGR3B/HLA-E/PPP3R1/KLRC1/NFATC2/HLA-A/CD48/RAC2/PRF1/FAS/HCST/KRAS/PIK3R1/BID/HLA-B/PPP3CC/CASP3/TYROBP/KLRD1/IFNGR1/KLRC3/ICAM1/NCR1/SYK/CD247	1.12414651072182
NA	NA	hsa03272	Virion - Hepatitis viruses	11/1565	48/9376	1.37294994675186	EPCAM/CD81/CHMP4A/CD9/CLDN3/CLDN9/CLDN1/OCLN/CHMP4B/LDLR/VPS4B	1.15948835078248
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/1565	69/9376	1.30240311154327	CAMK2D/TH/CALM2/PRKACB/CAMK4/PRKACA/JUN/PPP3R1/CALM1/GRIN2B/PPP1CB/PPP3CC/MAOB/ARC/ATF2	1.12848407336263
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1565	23/9376	1.56288373385192	ACAT2/PMVK/FDPS/MVK/MVD/HMGCR	1.20975281047032
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/1565	91/9376	1.25087947196573	IFITM1/CD81/NFKBIB/JUN/PPP3R1/NFATC2/RAC2/KRAS/NFATC3/PIK3R1/LILRB4/PPP3CC/DAPP1/NFKBIE/LILRA5/CHUK/BLNK/SYK/RELA	1.07642644644488
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1565	28/9376	1.49776357827476	TH/PCBD1/GCH1/QDPR/GPHN/GGH/ALPP	1.18068017187452
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1565	70/9376	1.28379735280694	HIF1A/ETS1/ELOB/MET/RAP1A/JUN/KRAS/PIK3R1/CRK/FLCN/VEGFA/RAP1B/CDKN1A/FH/VHL	1.06675656999148
Human Diseases	Infectious disease: viral	hsa05162	Measles	27/1565	136/9376	1.18940048862996	CCND1/CCND2/CDK6/IRF9/HSPA1A/IRF7/MSN/NFKBIB/JUN/STAT1/CCND3/MX2/STAT3/RAB9A/FAS/PIK3R1/BID/OAS2/HSPA8/CASP3/BCL2L1/CDKN1B/IL2RG/CHUK/RELA/IL6/CD3D	0.995873219957866
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1565	44/9376	1.36160325297705	HMGB1/ADPRS/POLD2/PARP1/APEX1/UNG/POLE3/NEIL1/NTHL1/PARP3	1.07612022099766
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1565	76/9376	1.26127459223138	CCND1/CAMK2D/CDK6/CAMK1D/CALM2/CDKN2A/CAMK4/DDB2/PDGFA/CALM1/GADD45G/GADD45B/PTEN/KRAS/PIK3R1/CDKN1A	1.02365117839283
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1565	60/9376	1.29806176783813	PLA2G4A/MAPKAPK3/PPP3R1/NFATC2/RAC2/KRAS/PIK3R1/PTGS2/PPP3CC/MAPKAPK2/VEGFA/MAPK13/HSPB1	1.03670847405436
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1565	87/9376	1.23952847857222	CCND1/EREG/AREG/DDB2/BCL2L11/JUN/GADD45G/RAC2/GADD45B/KRAS/PIK3R1/MYC/PMAIP1/CASP3/RALGDS/CDKN1A/RHOA/TGFBR1	1.00466619893607
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1565	98/9376	1.22266414553042	ASAP2/PLA2G4A/MARCKSL1/GSN/NCF1/FCGR3B/ARPC3/RAC2/CFL1/MARCKS/WASF3/PIK3R1/PTPRC/BIN1/CRK/SCIN/PRKCD/ASAP1/PIP5K1B/SYK	0.99180349517079
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1565	98/9376	1.22266414553042	CAMK2D/ATP2B4/CAMK1D/ATP2B1/CALM2/PRKACB/CAMK4/HSD3B1/PRKACA/CALM1/NR4A1/PRKD1/ITPR1/ADCY3/ATP1B1/ATF2/PRKD2/PLCB2/LDLR/ORAI1	0.99180349517079
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1565	14/9376	1.71172980374258	CHST2/ST3GAL1/B3GNT2/ST3GAL3	1.19284589957726
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	56/1565	300/9376	1.11833013844515	EREG/AREG/PLA2G4A/JUND/NGF/DUSP10/HSPA1A/RRAS/CDC25B/MAPKAPK3/MAP2K3/DUSP6/PRKACB/MET/EFNA5/PDGFA/PRKACA/RAP1A/JUN/RPS6KA2/EPHA2/CACNG4/PPP3R1/NTF4/GADD45G/NR4A1/RAC2/GADD45B/FAS/KRAS/NFATC3/PTPN7/MAP3K21/MYC/PPP3CC/HSPA8/MAPKAPK2/CASP3/PDGFD/CRK/MAP4K4/VEGFA/MAPK13/RAP1B/CACNA2D3/HSPB1/MAP3K13/DUSP5/ATF2/CHUK/KITLG/DUSP8/TGFBR1/RELA/RASGRP2/ECSIT	0.932391373200712
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1565	34/9376	1.40965983837625	POLR2L/POLR1F/POLR2I/POLR2J3/POLR2G/POLR3E/POLR1C/POLR3GL	1.07110588779797
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/1565	71/9376	1.2657156999505	CXCL8/ATP6V0C/ATP6V1B2/ADAM17/MET/JUN/CXCL2/ATP6V1F/HBEGF/CASP3/MAPK13/ATP6AP1/CHUK/CSK/RELA	1.00595300324874
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1565	19/9376	1.57659324028922	IDS/HPSE/HYAL3/HYAL1/HYAL2	1.12607553358347
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1565	88/9376	1.22544292767935	F3/SERPINB2/CLU/THBD/CD59/CD55/CFD/F12/ITGAX/F2R/C5/F5/C5AR1/C7/CFH/CFB/VTN/VWF	0.951056544987981
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	22/1565	110/9376	1.19821086261981	DCN/THBS1/EMP3/NBL1/THSD4/ID4/BMPR1A/PPP2CA/ACVR2A/TMEM53/ZFYVE16/SMURF2/SKI/BMP2/SMAD7/MYC/ACVR1B/TFDP1/NEO1/TFR2/RHOA/TGFBR1	0.935981223356219
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	20/1565	99/9376	1.21031400264627	EDN1/ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/ITGA1/TPM2/LMNA/CACNG4/SGCB/ITGA6/ITGB8/TNNC1/CACNA2D3/LAMA2/SNTA1/IL6/PRKAA2	0.941610945255583
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/1565	30/9376	1.39791267305644	ABCC2/FOLR3/TYMS/GGH/CHUK/RELA/IL6	0.977068473527431
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1565	73/9376	1.2310385574861	CCND1/CDK6/CDKN2A/EML4/MET/DDB2/RASSF5/GADD45G/FHIT/STAT3/KIF5B/GADD45B/KRAS/PIK3R1/CDKN1A	0.887000519426314
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/1565	95/9376	1.19821086261981	CXCL8/ATP6V0C/ATP6V1B2/CCL3L1/JUN/CXCL2/MMP1/ATP6V1F/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/VEGFA/ICAM1/ATP6AP1/TNFSF13/HLA-DMA/HLA-DMB/IL6	0.869123230406807
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1565	134/9376	1.1624433741834	AVPR1A/MYH14/EDN1/MYLK/KCNMB4/KCNMA1/PLA2G4A/GUCY1A1/CALM2/ADRA1B/MYL9/MYL6/EDN2/RAMP1/PRKACB/PRKACA/CALM1/MYL6B/ACTA2/PPP1CB/ITPR1/GUCY1B1/ADCY3/PRKCD/RHOA/PLCB2	0.847736552107162
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1565	41/9376	1.3151094833632	GRHPR/SDSL/SRR/PGAM4/CTH/PGAM1/MAOB/DLD/GAMT	0.905077421931511
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	47/1565	254/9376	1.10858091620337	AVPR1A/MYLK/CAMK2D/ATP2B4/CAMK1D/ORAI3/PLCD1/ATP2B1/CALM2/ADRA1B/GNA15/NGF/NTRK3/PRKACB/CAMK4/TNNC2/MET/VDAC2/ADRB2/PDGFA/PRKACA/PPIF/PPP3R1/CALM1/NFATC2/MST1R/VDAC1/GRIN2B/PTGFR/HRH1/NFATC3/OXTR/VDAC3/SLN/PPP3CC/F2R/TNNC1/PDGFD/ITPR1/VEGFA/STIM1/ADCY3/PTAFR/MCOLN1/ITPKB/PLCB2/ORAI1	0.785262424360484
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	34/1565	180/9376	1.13164359247426	IRF9/HLA-E/BST2/IRF7/SOCS3/STAT1/HLA-A/PPP1CB/TNFSF14/FAS/PIK3R1/BID/HLA-B/HLA-DPB1/OAS2/TNFRSF14/CASP3/SRSF2/BCL2L1/C5/HLA-DQA2/HLA-DRB5/EIF2B3/HLA-DRA/IFNGR1/HLA-F/BIRC3/B2M/CHUK/HLA-DMA/HLA-DMB/SYK/RELA/IL6	0.798226215581205
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1565	52/9376	1.26733841238634	LPL/OSBPL5/VAPA/VDAC2/SORT1/VDAC1/CD36/VDAC3/NCEH1/NPC1/LDLR	0.865269497562461
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1565	63/9376	1.23624930270298	ERCC6/POLR2L/POLR2I/POLR2J3/CETN2/POLD2/DDB2/XPA/POLR2G/POLE3/RPA3/GTF2H5/ERCC1	0.842142332460877
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1565	75/9376	1.19821086261981	MGST1/ABCC2/CDKN2A/XPA/GSTP1/GSTO2/FAS/PIK3R1/BID/PMAIP1/CASP3/BCL2L1/CDKN1A/BIRC3/ERCC1	0.771405536145068
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/1565	103/9376	1.16331151710661	COL3A1/LAMB3/COL1A2/COL4A5/COL4A6/CXCL8/LAMC2/GNA15/COL1A1/PRKACB/PRKACA/CXCL2/PIK3R1/CASP3/HSPB1/LAMA2/PLCB2/RELA/IL6/RAB5B	0.745958704367942
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1565	37/9376	1.29536309472412	CCND1/DDB2/CCDC6/GADD45G/GADD45B/KRAS/MYC/CDKN1A	0.805742727523751
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1565	59/9376	1.21851952130828	MGST1/ODC1/GPX1/GGCT/GGT5/LANCL1/GSTP1/GSTO2/RRM2B/SMS/RRM1/ANPEP	0.753646503817647
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1565	32/9376	1.31054313099042	BOK/BCL2L11/BID/PMAIP1/CASP3/BCL2L1/BIRC3	0.787625905464697
Human Diseases	Immune disease	hsa05310	Asthma	7/1565	32/9376	1.31054313099042	CD40/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/HLA-DMA/HLA-DMB	0.787625905464697
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	26/1565	138/9376	1.1287493633375	CAMK2D/CALM2/YWHAZ/PRKACB/PPP2CA/PRKACA/RPS6KA2/PPP3R1/CALM1/PPP1CB/PPP2R5C/CPEB2/PPP3CC/SPDYE2/ANAPC16/SLK/CPEB4/ITPR1/ADCY3/MAPK13/CDC26/PTTG1/YWHAH/YWHAB/ANAPC11/ANAPC15	0.682001209133409
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1565	76/9376	1.18244493021692	MYLK/CAMK2D/ACTB/CALM2/ACTG1/PRKACB/PRKACA/EZR/CALM1/ITPR1/KCNJ16/ADCY3/ATP1B1/GNAI3/PLCB2	0.714803403627379
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1565	54/9376	1.22039995266832	SDSL/CISD1/KYAT3/BCAT2/BCAT1/CTH/SMS/MDH1/GOT1/APIP/MDH2	0.727014910129571
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	21/1565	110/9376	1.14374673250073	TIMP1/EDN1/CAMK2D/GAPDH/PFKP/HIF1A/ALDOC/ELOB/ENO1/PGK1/STAT3/ENO2/PIK3R1/PFKM/VEGFA/IFNGR1/CDKN1B/CDKN1A/VHL/RELA/IL6	0.678793486699871
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1565	71/9376	1.18133465328713	PFKP/HIF1A/NTRK3/MET/SLC7A5/PTEN/KRAS/PIK3R1/PFKM/MYC/PGAM4/PGAM1/GLS/PKM	0.68650117061673
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1565	156/9376	1.11372163512739	CCND1/CDK6/CD81/IRF9/YWHAZ/IRF7/SOCS3/PPP2CA/CLDN3/STAT1/MX2/STAT3/PPP2R2B/FAS/KRAS/PIK3R1/BID/CLDN9/OAS2/MYC/CASP3/CLDN1/CDKN1A/YWHAH/OCLN/CHUK/YWHAB/LDLR/RELA	0.641105384413373
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	20/1565	105/9376	1.14115320249506	ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/PRKACB/ITGA1/TPM2/PRKACA/LMNA/CACNG4/SGCB/ITGA6/ITGB8/TNNC1/ADCY3/CACNA2D3/LAMA2/SNTA1	0.651045865349543
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1565	38/9376	1.26127459223138	ENPP1/NAMPT/BST1/SIRT2/NUDT12/NT5M/NNT/NADK	0.722356412340614
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1565	38/9376	1.26127459223138	SFN/NR3C2/NEDD4L/FXYD4/SCNN1A/KRAS/PIK3R1/ATP1B1	0.722356412340614
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	7/1565	33/9376	1.27082970277858	BCKDHB/BCAT2/BCAT1/IDH3A/DLD/GOT1/NAGS	0.697588927895062
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1565	17/9376	1.40965983837625	CYP7B1/SCP2/HSD3B7/SLC27A5	0.756698053158136
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1565	17/9376	1.40965983837625	MYH14/PCDH7/PCDH9/NRP2	0.756698053158136
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/1565	227/9376	1.08208469972273	CCND1/CDK6/CXCL8/CALM2/CDKN2A/HLA-E/PRKACB/CCL3L1/PRKACA/AKAP13/PPP3R1/CALM1/NFATC2/HLA-A/STAT3/RAC2/FAS/KRAS/NFATC3/PIK3R1/BID/HLA-B/MYC/PTGS2/PPP3CC/CASP3/CRK/ITPR1/VEGFA/ADCY3/MAPK13/HLA-F/CDKN1A/GNAI3/ATF2/B2M/CHUK/RHOA/PLCB2/RELA/IL6	0.560373796114333
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	33/1565	181/9376	1.09229167034402	CAMK2D/HSPD1/CALM2/FCGR3B/ATP6V0C/CTSS/CLEC7A/STAT1/PPP3R1/CALM1/ITGAX/CORO1A/BID/HLA-DPB1/PLA2R1/PPP3CC/RIPK2/CASP3/EEA1/HLA-DQA2/HLA-DRB5/HLA-DRA/IFNGR1/NOD2/MAPK13/ATP6AP1/HLA-DMA/RHOA/HLA-DMB/SYK/RELA/IL6/RAB5B	0.561197098582695
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1565	28/9376	1.28379735280694	B3GNT3/B3GNT2/GCNT2/ST3GAL3/FUT4/B3GNT4	0.673158748277621
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	13/1565	67/9376	1.1624433741834	GAPDH/PFKP/ALDOC/ENO1/PGK1/TPI1/GPI/ENO2/PFKM/PGAM4/PGAM1/DLD/PKM	0.59727918265259
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1565	12/9376	1.49776357827476	NCAM2/NCAM1/NPC1	0.772275978749204
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1565	23/9376	1.30240311154327	GLS/ATP1B1/MDH1/SLC9A3/GLUD1	0.649926427223208
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	38/1565	212/9376	1.07386822593285	THBS1/ACTB/CALM2/NGF/MAGI2/PFN2/RRAS/ACTG1/MAP2K3/MET/EFNA5/PDGFA/RAP1A/RASSF5/EPHA2/RAPGEF6/CALM1/PFN4/RAC2/GRIN2B/KRAS/PRKD1/PIK3R1/F2R/PDGFD/CRK/VEGFA/FPR1/RALGDS/ADCY3/MAPK13/RAP1B/GNAI3/KITLG/PRKD2/RHOA/PLCB2/RASGRP2	0.486936746095186
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/1565	195/9376	1.07531744081265	ACTB/H3-3B/HMGB1/H2AJ/H3-3A/MACROH2A1/CYBA/ACTG1/NCF1/FCGR3B/H2BC12/VDAC2/CASP4/H2AZ1/PPIF/CLEC7A/H2AZ2/H4C3/H2AC20/RAC2/VDAC1/MACROH2A2/VDAC3/PIK3R1/C5/AZU1/FPR1/MAPK13/H2AC8/C5AR1/PLCB2/SYK/RELA/H2BC11/VWF	0.475726514143603
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1565	166/9376	1.0827206589938	MYLK/KCNMB4/ATP2B4/KCNMA1/ATP2B1/GUCY1A1/CALM2/ADRA1B/MYL9/PDE3A/VDAC2/ADRB2/PPIF/PPP3R1/CALM1/NFATC2/VDAC1/CNGA1/PPP1CB/NFATC3/VDAC3/PPP3CC/ITPR1/GUCY1B1/ADCY3/ATP1B1/GNAI3/ATF2/RHOA/PLCB2	0.481313125053662
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1565	18/9376	1.3313454029109	ACSL3/ACSL1/MCAT/ACSF3	0.629818150021097
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1565	63/9376	1.14115320249506	WNT5A/WNT2/FZD6/WNT10A/WNT6/DDB2/GADD45G/FZD1/WNT11/BMP2/GADD45B/CDKN1A	0.503159526074701
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1565	46/9376	1.17216280038894	FTH1/FTL/BLVRA/MMAB/EPRS1/BLVRB/CP/UROS/PPOX	0.523922322309981
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1565	86/9376	1.1146147559254	ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/ITGA1/LMNA/CDH2/CACNG4/SGCB/ITGA6/ITGB8/CACNA2D3/LAMA2/SNTA1	0.477937813894146
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1565	35/9376	1.19821086261981	PFKP/SORD/ALDOC/TPI1/PFKM/TKFC/HSD17B14	0.525840797544535
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1565	226/9376	1.06036359523877	EDN1/CAMK2D/ATP2B4/PDE4D/SOX9/ATP2B1/CALM2/MYL9/RRAS/EDN2/PRKACB/CAMK4/PDE3A/ADRB2/PRKACA/RAP1A/HCAR3/JUN/ACOX1/CALM1/SSTR1/RAC2/PDE4B/GRIN2B/CNGA1/PPP1CB/HTR1B/OXTR/PIK3R1/F2R/ADCY3/ATP1B1/RAP1B/GABBR1/GNAI3/RHOA/RELA/HTR1F/PDE4A/ORAI1	0.411157542031312
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1565	98/9376	1.10039773097738	PLCD1/DGKB/CALM2/PIK3C2G/DGKD/ITPK1/CALM1/BPNT2/INPP4B/PTEN/PIK3R1/CDS1/INPP5F/ITPR1/ITPKB/SACM1L/PIP5K1B/PLCB2	0.447197370970419
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	30/1565	168/9376	1.06983112733911	CCND1/CCND2/IRF9/SOCS3/PRL/PDGFA/CLCF1/STAT1/IL4R/CCND3/GHR/IL22RA1/PIAS2/STAT3/STAM/SOCS1/PIK3R1/MYC/SOCS6/BCL2L1/IFNGR1/OSMR/IFNLR1/PRLR/CDKN1A/CTF1/LEPR/IL2RG/SOCS5/IL6	0.408799662941132
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/1565	157/9376	1.06846828513868	THBS1/CAMK2D/GAS6/ITGB5/PBX1/ATP11B/HIF1A/ODC1/ADAM17/AXL/P2RY2/NFATC2/ALOX5/VPS11/CD36/XKR6/NFATC3/PTGS2/MAPKAPK2/CASP3/CRK/CD47/SIRPA/MFGE8/MAPK13/DUSP5/DUSP8/RAB5B	0.387245927877732
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1565	47/9376	1.14722316633811	GRHPR/ACAT2/ACYP2/ME3/DLD/MDH1/FH/PKM/MDH2	0.452894479110127
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1565	99/9376	1.08928260238164	CAMK2D/PLA2G4A/CALM2/NGF/MAP2K3/PRKACB/PRKACA/P2RY2/TRPV3/CALM1/PPP1CB/HRH1/PIK3R1/ITPR1/ADCY3/MAPK13/PRKCD/PLCB2	0.399733135053567
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	14/1565	76/9376	1.10361526820245	ACSL3/ACSL1/LPL/SLC27A6/FABP5/ME3/SCP2/MMP1/ACOX1/SLC27A5/CD36/DBI/SCD5/OLR1	0.405955628861927
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1565	82/9376	1.09592456946934	MGST1/DPYD/NME3/GSTP1/GSTO2/NME7/IMPDH1/NME1/HPRT1/RRM2B/TPMT/UPP1/TK1/GMPS/RRM1	0.390503509264846
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1565	36/9376	1.16492722754704	GALNT13/GALNT5/B4GALT5/B3GNT3/GALNTL6/ST3GAL1/C1GALT1	0.443771759091546
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1565	158/9376	1.0617058276378	WNT5A/WNT2/FZD6/WNT10A/FNIP2/ATP6V1B2/WNT6/RPS6KA2/SLC7A5/PRR5L/FZD1/WNT11/FNIP1/PTEN/ATP6V1F/KRAS/PIK3R1/LAMTOR4/FLCN/LRP5/CAB39L/LAMTOR5/LAMTOR2/AKT1S1/CHUK/RHOA/TBC1D7/PRKAA2	0.350127210354981
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1565	94/9376	1.083488545986	S100A8/HSP90AB1/S100A9/CXCL8/IL17RC/JUND/HSP90AA1/JUN/CXCL2/MMP1/FOSL1/PTGS2/CASP3/MAPK13/CHUK/RELA/IL6	0.364132575219996
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1565	65/9376	1.10604079626444	PBX1/PRKACB/HSD3B1/PRKACA/NR4A1/ITPR1/ADCY3/NCEH1/ATF2/PLCB2/LDLR/ORAI1	0.383990946924556
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/1565	200/9376	1.04843450479233	MYH14/ACTB/FYN/TUBA4A/GAPDH/TUBA1A/CXCL8/ACTG1/CASP4/CLDN3/EZR/NFKBIB/JUN/BRK1/ARPC3/NAIP/TMED10/FAS/WASF3/MYO5A/CLDN9/NCL/CYTH4/MYO5B/F2R/NCKAP1L/CASP3/CLDN1/ABL1/MAPK13/OCLN/CHUK/RHOA/RELA/IL6	0.309907901569343
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1565	101/9376	1.06771264985924	WNT5A/WNT2/EDN1/CAMK2D/CALM2/FZD6/WNT10A/PRKACB/WNT6/PRKACA/CALM1/FZD1/WNT11/KRAS/ADCY3/GNAI3/KITLG/PLCB2	0.306240783874499
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	27/1565	154/9376	1.05037965229659	MMAB/ADSS2/EPRS1/NQO1/GGCX/GCH1/NME3/BCAT2/MTHFD2L/NME7/BCAT1/NME1/AK4/GPHN/COQ3/COQ4/AK3/UROS/GGH/ALPP/COQ5/PPOX/PPCS/DLD/NADK/CTPS1/KMO	0.282158057978862
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1565	73/9376	1.06690008315462	CCND1/CDK6/CDKN2A/MET/DDB2/PDGFA/GADD45G/GADD45B/PTEN/KRAS/PIK3R1/PDGFD/CDKN1A	0.256842014395731
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1565	38/9376	1.10361526820245	CD40/UNG/PTPRC/IL2RG/BLNK/CD3D/ORAI1	0.286469314766564
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/1565	103/9376	1.04698036539595	CXCL8/GNA15/CCL3L1/PPP2CA/JUN/PPP2R2B/FAS/PIK3R1/IFNGR1/MAPK13/GNAI3/CHUK/PLCB2/TGFBR1/RELA/IL6/CD3D/CD247	0.214592412846284
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1565	50/9376	1.07838977635783	CKB/ODC1/SMOX/SAT2/MAOB/ALDH4A1/SMS/GAMT/GOT1	0.248763244386259
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/1565	50/9376	1.07838977635783	CD40/HLA-DPB1/HLA-DQA2/HLA-DRB5/HLA-DRA/TNFSF13/HLA-DMA/HLA-DMB/IL6	0.248763244386259
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1565	62/9376	1.0629289910337	SOD2/CRYAB/HSPA1A/PRKACB/PRKACA/KRAS/PIK3R1/HSPA8/ADCY3/AKT1S1/PRKAA2	0.222519454582606
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1565	15/9376	1.19821086261981	AK4/THTPA/ALPP	0.343875669343745
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1565	110/9376	1.03481847226256	HSP90AB1/HSP90AA1/CDC25B/PRKACB/PRKACA/RPS6KA2/KRAS/PIK3R1/CPEB2/SPDYE2/ANAPC16/CPEB4/KIF22/ADCY3/MAPK13/CDC26/GNAI3/ANAPC11/ANAPC15	0.164418013387175
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/1565	122/9376	1.0312470538941	FYN/PPP2CA/NFKBIB/JUN/PPP3R1/NFATC2/PPP2R2B/PPP2R5C/KRAS/NFATC3/PIK3R1/PTPRC/PPP3CC/NFKBIE/MAPK13/TEC1/CHUK/RHOA/RELA/CD3D/CD247	0.155494035362124
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1565	27/9376	1.10945450242575	OXCT1/ACAT2/ECHS1/ABAT/HMGCL	0.254930867283043
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/1565	158/9376	1.02378776236503	CCND1/CCND2/SFN/CDK6/CDKN2A/CDC25B/YWHAZ/PPP2CA/CCND3/GADD45G/PPP2R5C/GADD45B/MYC/ANAPC16/ABL1/CDKN2C/CDC26/CDKN1B/CDKN1A/TFDP1/CHEK1/PTTG1/RAD21/YWHAH/YWHAB/ANAPC11/ANAPC15	0.134974980423909
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1565	33/9376	1.08928260238164	STX19/VAMP2/STX11/SEC22B/STX4/VAMP5	0.22996943923101
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1565	63/9376	1.04605710228713	PLAAT2/PTGDS/PLA2G4A/GGT5/ALOX5/PTGR3/LTA4H/PTGS2/LTC4S/PLB1/PTGES3	0.164176719688526
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/1565	99/9376	1.02876690224933	DGKB/PLA2G4A/HIF1A/CHPT1/PDGFA/JUN/DGKD/SLC44A3/GPCPD1/RAC2/KRAS/WASF3/PIK3R1/SLC44A1/PDGFD/RALGDS/PIP5K1B	0.128794229952559
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1565	105/9376	1.02703788224555	CD40/CXCL8/CYLD/CXCL2/GADD45G/PARP1/TNFSF14/GADD45B/PTGS2/BCL2L1/BCL2A1/ICAM1/BIRC3/CHUK/EDARADD/BLNK/SYK/RELA	0.124707772353871
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/1565	117/9376	1.024111848393	ACTB/H2AJ/MACROH2A1/ACTG1/H2AZ1/MEAF6/H2AZ2/H2AC20/GATAD2B/MACROH2A2/POLE3/SMARCA5/BAZ1A/DPF3/CDK2AP1/RBBP4/H2AC8/ARID1B/PHF10/RUVBL2	0.117471058842764
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/1565	130/9376	1.01387072990907	COL3A1/EDN1/COL1A2/COL4A5/COL4A6/GNA15/COL1A1/PRKACB/PRKACA/JUN/MMP1/ACTA2/KRAS/PIK3R1/VEGFA/ADCY3/MAPK13/GNAI3/ATF2/PLCB2/TGFBR1/RELA	0.0712826008306501
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1565	70/9376	1.02703788224555	ACSL3/ADIPOR2/ACSL1/SOCS3/NFKBIB/STAT3/CD36/NFKBIE/LEPR/CHUK/RELA/PRKAA2	0.1016318095952
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1565	52/9376	1.03691324649791	PLA2G4A/PRKACB/HSD3B1/PRKACA/ALOX5/HSD17B7/PTGS2/ADCY3/LDLR	0.119473688668764
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1565	149/9376	1.00521045521796	AVPR1A/FYN/AGPAT2/DGKB/PLA2G4A/CXCL8/RRAS/PDGFA/DGKD/AGPAT3/PTGFR/KRAS/PIK3R1/CYTH4/F2R/GRM7/PDGFD/AGPAT5/RALGDS/ADCY3/KITLG/PIP5K1B/RHOA/PLCB2/SYK	0.028696440598662
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	24/1565	143/9376	1.00549163296767	CD40/H3-3B/H2AJ/H3-3A/MACROH2A1/FCGR3B/H2BC12/H2AZ1/H2AZ2/SSB/H4C3/H2AC20/MACROH2A2/GRIN2B/HLA-DPB1/C5/HLA-DQA2/HLA-DRB5/HLA-DRA/H2AC8/C7/HLA-DMA/HLA-DMB/H2BC11	0.0296201732721536
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/1565	125/9376	1.00649712460064	CERS6/FYN/PPP2CA/SGMS1/RAC2/PPP2R2B/PPP2R5C/PTEN/S1PR3/KRAS/PIK3R1/BID/ASAH1/SGMS2/MAPK13/ORMDL2/SPTSSA/GNAI3/RHOA/PLCB2/RELA	0.0327319102685092
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1565	107/9376	1.00784091248395	CAMK2D/CALM2/PFKP/PRKACB/PRKACA/PPP3R1/CALM1/PFKM/PPP4R3A/PPP3CC/PGAM4/PGAM1/ITPR1/ATF2/PKM/PLCB2/PPP4C/PRKAA2	0.0365116571379897
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1565	65/9376	1.01387072990907	AGPAT2/DGKB/MBOAT2/LPL/DGKD/MBOAT1/AGPAT3/DGAT1/TKFC/GPAT3/AGPAT5	0.0502281659507322
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1565	59/9376	1.01543293442357	PLAAT2/PRKACB/ADRB2/PRKACA/CIDEC/PIK3R1/PTGS2/ABHD5/ADCY3/GNAI3	0.05322626098727
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/1565	174/9376	0.998509052183174	HSP90AB1/FBXO2/CRYAB/HSP90AA1/HSPA1A/BAG1/UBE2D1/HSPH1/SEC61B/MARCHF6/DNAJB1/EIF2AK3/ERN1/DAD1/ERO1B/HSPA8/SVIP/PRKN/NFE2L2/VCP/UBQLN1/DNAJC3/STUB1/ATF6/SEC61G/DNAJB11/CAPN2/TMEM258/UBE2D2	-0.00888557308444896
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/1565	108/9376	0.998509052183174	SAP18/EIF4A3/THOC7/NUP214/SUMO3/KPNB1/SUMO1/SRRM1/POM121C/SUMO2/RANBP17/RNPS1/XPO6/NUP37/PHAX/RANBP2/RAN/KPNA6	-0.00697542701263063
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	13/1565	78/9376	0.998509052183174	CXCL8/CALM2/JUN/CALM1/CFL1/CASP3/IRF1/C5/MAPK13/GNAI3/RHOA/RELA/IL6	-0.0059184020455167
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	28/1565	169/9376	0.992600714596291	HMGB1/RPS27A/HIF1A/UBA52/RRAS/OPTN/UBB/PRKACB/MAP1LC3A/PPP2CA/PRKACA/TANK/GABARAPL2/VPS11/BNIP3/EIF2AK3/PTEN/KRAS/ERN1/PIK3R1/BCL2L1/ITPR1/PRKCD/AKT1S1/RB1CC1/SQSTM1/ATG9B/PRKAA2	-0.0434473757726105
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1565	23/9376	1.04192248923462	GLS/GLUD1/GOT1/NAGS	0.0901000439760975
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/1565	163/9376	0.992383229777142	CXCL8/MAP2K3/YWHAZ/IRF7/DDB2/JUN/STAT1/NFATC2/STAT3/FAS/KRAS/NFATC3/VDAC3/PIK3R1/BID/MYC/CASP3/EGR2/MAPK13/CDKN1A/ATP6AP1/ATF2/CHUK/YWHAB/TGFBR1/RELA/IL6	-0.0439090065455184
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/1565	72/9376	0.998509052183174	CXCL8/IRF7/CYLD/NFKBIB/TANK/PIN1/ZNFX1/TKFC/MAPK13/RNF125/CHUK/RELA	-0.00568438298757996
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/1565	133/9376	0.991001465324653	CCND1/CCND2/SOD2/BCL2L11/BCL6/GADD45G/GABARAPL2/BNIP3/STAT3/GADD45B/PTEN/KRAS/PIK3R1/USP7/MAPK13/CDKN1B/CDKN1A/CHUK/SGK3/TGFBR1/IL6/PRKAA2	-0.0467821986486981
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1565	17/9376	1.05724487878218	CA5B/CA13/GLUD1	0.105739162763542
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1565	103/9376	0.988814789540619	COL3A1/COL7A1/KCNN4/COL1A2/COL4A5/COL4A6/COL12A1/COL1A1/COL9A3/PRSS3/COL5A2/SLC1A1/ACE2/COL6A2/ATP1B1/COL6A3/SLC9A3	-0.0510907329145454
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1565	42/9376	0.998509052183174	ACAT2/ECHS1/KYAT3/MAOB/DLD/GCDH/KMO	-0.00433453666160138
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1565	30/9376	0.998509052183174	PIGP/PGAP4/PGAP2/PIGT/PIGC	-0.00366099952611726
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1565	61/9376	0.982140051327712	FTH1/ATP2B4/FTL/ATP2B1/MT2A/ATOX1/STEAP1/MT1E/ATP1B1/SLC9A3	-0.062638764722549
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	9/1565	55/9376	0.980354342143479	CERS6/B4GALT5/SAMD8/SGMS1/B4GALT6/CERK/ASAH1/SGMS2/KDSR	-0.0654042782088402
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1565	86/9376	0.975287911434728	KCNN4/KCNMB4/CAMK2D/KCNMA1/RIMS2/PCLO/PRKACB/PRKACA/TRPM4/VAMP2/ADCY3/ATP1B1/ATF2/PLCB2	-0.103048176391283
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1565	80/9376	0.973546325878594	GAS6/MET/AXL/PDGFA/BCL2L11/STAT3/PTEN/KRAS/PIK3R1/PDGFD/BCL2L1/VEGFA/IL6	-0.106358554296286
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1565	43/9376	0.975287911434728	ACSL3/ACSL1/ACAT2/ECI2/ECHS1/ACOX1/GCDH	-0.0726980123461387
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1565	154/9376	0.972573752126468	CAMK2D/ATP2B4/ATP2B1/CALM2/ADRA1B/PRKACB/PPP2CA/ADRB2/TPM2/PRKACA/CACNG4/CALM1/PPP2R2B/PPP1CB/PPP2R5C/MYL4/TNNC1/ADCY3/ATP1B1/MAPK13/CACNA2D3/GNAI3/ATF2/PLCB2/CREM	-0.153604411401769
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/1565	68/9376	0.969141138883668	CCND1/DUSP6/RARA/STAT3/ZBTB16/KRAS/PIK3R1/MYC/BCL2A1/CHUK/RELA	-0.114313008089471
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/1565	99/9376	0.968251202117017	CCND1/CDKN2A/PRKACB/BIK/PRKACA/JUN/NOTCH2/KRAS/PIK3R1/HBEGF/CDKN2C/ADCY3/MAPK13/CDKN1B/CDKN1A/JAG1	-0.142144675148449
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1565	18/9376	0.998509052183174	MMAB/TCN2/MMADHC	-0.00283397924800567
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1565	37/9376	0.971522321043088	ADSS2/ABAT/GLS/ALDH4A1/GLUD1/GOT1	-0.0776863566442535
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1565	37/9376	0.971522321043088	PNMT/TH/COMT/FAH/MAOB/GOT1	-0.0776863566442535
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1565	93/9376	0.96629908275791	CAMK2D/PLA2G4A/CALM2/MAP2K3/PRKACB/PRKACA/JUN/CALM1/KRAS/HBEGF/ITPR1/ADCY3/MAPK13/PRKCD/PLCB2	-0.146193650454978
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1565	31/9376	0.96629908275791	DPYD/ECHS1/ACOX1/SMOX/ABAT	-0.0841244824888387
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1565	31/9376	0.96629908275791	GRHPR/ACAT2/DLD/MDH1/MDH2	-0.0841244824888387
NA	NA	hsa04981	Folate transport and metabolism	5/1565	31/9376	0.96629908275791	ABCC2/FOLR3/TYMS/SLCO1B3/ST20-MTHFS	-0.0841244824888387
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/1565	63/9376	0.950961002079213	ACAT2/ECHS1/KMT2A/SETD2/TMLHE/DLD/CAMKMT/GCDH/KMT2E/EZH2	-0.174806086697649
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1565	51/9376	0.939773225584163	PLAAT2/PLA2G4A/CHPT1/PEDS1/LPCAT2/PLB1/PAFAH1B3/PAFAH1B1	-0.193036645586226
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1565	83/9376	0.938357904461296	POLR2L/ZDHHC1/IRF7/NFKBIB/SAMHD1/POLR3E/POLR1C/POLR3GL/CASP3/MLKL/CHUK/RELA/IL6	-0.252480570061936
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1565	102/9376	0.939773225584163	ATP2B4/KCNMA1/ATP2B1/RAB27B/BST1/PRSS3/RAP1A/SLC12A2/ITPR1/ADCY3/ATP1B1/RAP1B/TRPC1/RHOA/PLCB2/RAB3D	-0.2737446464097
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1565	26/9376	0.921700663553699	PLAAT2/PLA2G4A/ACOX1/PLB1	-0.178948655771127
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1565	26/9376	0.921700663553699	AMN/TCN2/CUBN/PLB1	-0.178948655771127
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/1565	90/9376	0.931941782037629	SOD2/ADIPOR2/SESN3/PRKACB/CAMK4/PRKACA/KRAS/PIK3R1/ADCY3/AKT1S1/RB1CC1/ATF2/RELA/PRKAA2	-0.290386872016394
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/1565	122/9376	0.933033048761326	CCND1/ACTB/PLCD1/PFKP/HIF1A/KAT2B/ACTG1/PRKACB/PRKACA/STAT1/NOTCH2/KRAS/PIK3R1/PFKM/MYC/ATP1B1/DIO3/PLCB2/THRA	-0.333246184401627
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/1565	122/9376	0.933033048761326	MAP2K3/PRKACB/SOCS3/PRKACA/JUNB/STAT1/GHR/SSTR1/STAT3/KRAS/SOCS1/PIK3R1/CRK/ITPR1/ADCY3/MAPK13/GNAI3/ATF2/PLCB2	-0.333246184401627
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1565	78/9376	0.921700663553699	ACTB/CAV1/ACTG1/SEPTIN1/CAV2/CD2AP/MET/ARPC3/SEPTIN6/PIK3R1/CRK/RHOA	-0.310813663467309
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1565	59/9376	0.91388964098121	CCND1/DDB2/GADD45G/GADD45B/PTEN/KRAS/PIK3R1/MYC/CDKN1A	-0.296983860427918
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1565	53/9376	0.904310084996082	ATP2B4/ATP2B1/AP2S1/PRKACB/PRKACA/AP2A1/ATP1B1/PLCB2	-0.31269126666482
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1565	86/9376	0.90562448918939	EREG/CAMK2D/AREG/ABL2/JUN/KRAS/PIK3R1/HBEGF/MYC/ABL1/CRK/CDKN1B/CDKN1A	-0.393541171533997
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	22/1565	144/9376	0.915299964501243	RORA/SPTBN2/VDAC2/PPIF/VDAC1/GRIN2B/ERN1/VDAC3/PIK3R1/ITPR1/PSMA7/PSMD6/OMA1/GTF2B/RB1CC1/PSMB1/PSMC5/PSMB6/PSMD12/PLCB2/PSMD9/PSMC6	-0.458465257831618
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1565	62/9376	0.869669174482119	KAT2B/ADAM17/HES1/NUMB/NOTCH2/CTBP1/PSEN1/RFNG/JAG1	-0.46085506430587
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/1565	133/9376	0.900910423022412	CAMK2D/TH/CALM2/PRKACB/PPP2CA/PRKACA/CALM1/KIF5B/GRIN2B/PPP2R2B/PPP1CB/PPP2R5C/PPP3CC/COMT/MAOB/ITPR1/MAPK13/GNAI3/ATF2/PLCB2	-0.515153682396906
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1565	49/9376	0.855864901871292	GALNT13/GALNT5/GALNTL6/RFNG/C1GALT1/OGT/ST3GAL3	-0.452779014615604
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1565	29/9376	0.826352319048144	CALM2/CALM1/RGS9/CNGA1	-0.419200078755722
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1565	36/9376	0.832090876819311	ENPP1/MGAM/GPI/PGM2L1/GYG1	-0.451795183061346
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1565	89/9376	0.875097821014467	TUBA4A/TUBA1A/GUCY1A1/PRKACB/PDGFA/PRKACA/KRAS/PDGFD/ITPR1/GUCY1B1/ADCY3/GNAI3/PLCB2	-0.52992790071185
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1565	148/9376	0.89056212762283	WNT5A/CCND1/WNT2/CDK6/FZD6/WNT10A/WNT6/HES1/DDB2/JUN/GADD45G/FZD1/NOTCH2/WNT11/GADD45B/PTEN/KRAS/PIK3R1/MYC/LRP5/CDKN1A/JAG1	-0.600667585401165
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1565	37/9376	0.809601934202573	HBB/FAS/ICAM1/PLCB2/IL6	-0.519400898728256
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1565	23/9376	0.781441866925962	POMGNT2/ST3GAL3/FUT4	-0.469726339271013
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	36/1565	238/9376	0.906209896099015	PLAAT2/PLA2G4A/CALM2/NGF/RRAS/ETS1/PRKACB/MET/EFNA5/PDGFA/PRKACA/ABL2/RAP1A/RASSF5/EPHA2/NTF4/CALM1/RAC2/GRIN2B/SYNGAP1/KRAS/PIK3R1/PDGFD/ABL1/RALGAPA1/BCL2L1/VEGFA/RIN1/RALGDS/RAP1B/CHUK/KITLG/RHOA/RELA/RAB5B/RASGRP2	-0.656008412765926
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1565	16/9376	0.74888178913738	MAOB/GOT1	-0.44997642988646
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/1565	78/9376	0.844892274924224	PLCD1/PIK3C2G/TPI1/ITPK1/INPP4B/PTEN/INPP5F/ITPKB/SACM1L/PIP5K1B/PLCB2	-0.615708924889101
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1565	66/9376	0.816961951786233	CYP7B1/SULT2B1/HSD11B1/HSD17B12/HSD3B1/HSD17B7/HSD11B1L/SRD5A3/COMT	-0.667925452961203
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/1565	106/9376	0.847790704683827	HSP90AB1/CCND1/SPINT1/HSP90AA1/FOLR3/PDGFA/GSTP1/PTEN/KRAS/PIK3R1/PDGFD/CDKN1B/CDKN1A/CHUK/RELA	-0.705413442001033
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1565	39/9376	0.768083886294749	MTHFD2L/TYMS/CTH/DLD/ST20-MTHFS	-0.649604521557129
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/1565	100/9376	0.838747603833866	CXCL8/CCL3L1/XCL1/CXCL2/XCL2/IL22RA1/TNFRSF10C/TNFSF14/TNFRSF14/CCL27/CXCL14/IL2RG/IL18R1/IL6	-0.725630112747058
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1565	60/9376	0.798807241746539	PLA2G4A/GUCY1A1/PPP2CA/KRAS/ITPR1/GUCY1B1/GNAI3/PLCB2	-0.699781924104434
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1565	140/9376	0.855864901871292	CCND1/MYLK/CALM2/RRAS/PRKACB/CAMK4/MAP1LC3A/PRKACA/CALM1/ACTA2/KRAS/MYL4/ITPR1/ADCY3/GNAI3/CCN2/PLCB2/TGFBR1/JAG1/PRKAA2	-0.769097313010751
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1565	54/9376	0.776618151698024	HES1/FANCL/RPA3/RMI2/CENPS/ERCC1/FANCF	-0.736851040128103
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/1565	193/9376	0.869168501382244	CXCL8/NCF1/PRKACB/CCL3L1/XCL1/PRKACA/RAP1A/NFKBIB/CXCL2/STAT1/XCL2/STAT3/RAC2/KRAS/PIK3R1/CCL27/CRK/CXCL14/ADCY3/PREX1/PRKCD/RAP1B/GNAI3/CHUK/RHOA/PLCB2/RELA/RASGRP2	-0.822030948753578
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1565	115/9376	0.833537991387693	CAMK2D/SLC18A3/FYN/PRKACB/CHAT/ACHE/CAMK4/PRKACA/KCNQ3/KCNQ5/KRAS/PIK3R1/ITPR1/ADCY3/GNAI3/PLCB2	-0.80394177996599
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1565	75/9376	0.798807241746539	GPX1/PRKACB/PRKACA/ITPR1/TTF1/ADCY3/ATP1B1/ATF2/PLCB2/DUOX1	-0.783010605461671
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1565	18/9376	0.665672701455449	MANBA/FUCA1	-0.635486108517108
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1565	89/9376	0.807782604013354	GABRP/PRKACB/PRKACA/TRAK2/GABARAPL2/ABAT/SLC38A5/GPHN/GLS/ADCY3/GABBR1/GNAI3	-0.815529096152117
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1565	69/9376	0.781441866925962	FYN/PLA2G4A/MAP2K3/ALOX5/RAC2/KRAS/PIK3R1/MAPK13/SYK	-0.815597997716476
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1565	41/9376	0.730616379646225	POLD2/RAD51B/NBN/RPA3/ABRAXAS1	-0.773740701225885
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1565	10/9376	0.599105431309904	BPNT2	-0.567730970193593
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1565	97/9376	0.802924804848325	CAMK2D/GUCY1A1/CALM2/PRKACB/PER3/PRKACA/CALM1/GRIN2B/ITPR1/GUCY1B1/ADCY3/GNAI3/PLCB2	-0.873286477440914
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1565	19/9376	0.630637296115689	BCKDHB/DLD	-0.721358272694501
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1565	28/9376	0.641898676403469	ATP6V0C/ATP6V1B2/ATP6V1F	-0.849405522513061
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1565	20/9376	0.599105431309904	CYB5R1/CYB5R3	-0.803321802348631
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1565	44/9376	0.680801626488527	DAD1/MGAT2/ST3GAL3/B4GALNT3/TMEM258	-0.949924596687893
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1565	44/9376	0.680801626488527	GTF2F2/TAF13/GTF2H5/TAF7/GTF2B	-0.949924596687893
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1565	29/9376	0.619764239286108	RASSF2/FAT4/YAP1	-0.917921045436809
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1565	21/9376	0.570576601247528	CSGALNACT2/CHSY3	-0.88178548691143
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/1565	109/9376	0.769493214526482	SLC27A6/SOCS3/RPS6KA2/SLC27A5/STAT3/CD36/PPP1CB/PTEN/PIK3R1/PRKCD/OGT/RELA/IL6/PRKAA2	-1.08346995334991
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1565	144/9376	0.790486332978346	WNT5A/HAND1/WNT2/MEIS1/FZD6/ID4/WNT10A/BMPR1A/PCGF5/WNT6/ACVR2A/FZD1/STAT3/WNT11/KRAS/PIK3R1/MYC/ACVR1B/MAPK13	-1.13405781715097
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1565	30/9376	0.599105431309904	PLAAT2/PLA2G4A/PLB1	-0.984390472579666
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1565	68/9376	0.704829919188123	CYP26B1/DHRS4L2/ALDH1A3/PNPLA4/DGAT1/CYP27C1/ALDH1A2/CYP2W1	-1.09342271927724
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/1565	138/9376	0.781441866925962	ACTB/CXCL8/ACTG1/MAP2K3/JUN/RPS6KA2/NFATC2/ARPC3/RAC2/NFATC3/PIK3R1/CRK/MAPK13/CHUK/PIP5K1B/RHOA/RELA/IL6	-1.15772930567198
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1565	90/9376	0.732239971600994	ABCC2/PRKACB/PRKACA/SLC27A5/HMGCR/SLCO1B3/ADCY3/ATP1B1/NCEH1/SLC9A3/LDLR	-1.14246301807076
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	42/1565	298/9376	0.844376782383086	CD40/IL36RN/CXCL8/IL17RC/NGF/IL1RL2/IL1RN/BMPR1A/TNFSF12/CCL3L1/PRL/XCL1/CXCL2/CLCF1/XCL2/IL4R/ACVR2A/GHR/IL22RA1/IL32/BMP2/TNFRSF10C/TNFSF14/FAS/TNFRSF18/TNFRSF14/TNFRSF21/CCL27/ACVR1B/CXCL14/IFNGR1/OSMR/IFNLR1/PRLR/CTF1/TNFRSF6B/LEPR/IL2RG/IL18R1/TNFSF13/TGFBR1/IL6	-1.22201608798472
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1565	47/9376	0.637346203521175	SOCS3/SOCS1/PIK3R1/PRKCD/PKM	-1.11561180443833
NA	NA	hsa04519	Cadherin signaling	58/1565	404/9376	0.86010185683105	VIM/KRT6A/KRT5/WNT5A/DSG1/GABRP/DSC3/KRT24/WNT2/PCDH7/KRT17/KRT16/ACTB/PKP1/PCDH9/KRT14/CDH10/CDH11/PRICKLE1/FZD6/RRAS/WNT10A/ACTG1/MAP2K3/DSG3/YWHAZ/MET/WNT6/KRT6C/CIB2/CDH2/BRK1/ARPC3/FZD1/WNT11/RAC2/KRT13/PPP1CB/PSEN1/KRAS/KRT10/NCKAP1L/FAT4/LRP5/ERBIN/MAPK13/KRT27/KRT86/KRT78/YAP1/YWHAH/CHUK/RHOA/TMC6/PKP3/YWHAB/RELA/LHFPL2	-1.28661168277851
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1565	23/9376	0.520961244617308	POLD2/RPA3	-1.02955272251812
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1565	23/9376	0.520961244617308	ACE2/ANPEP	-1.02955272251812
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1565	32/9376	0.561661341853035	PFKP/MGAM/PFKM	-1.11175179248721
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/1565	32/9376	0.561661341853035	PPP2CA/GABARAPL2/ATG9B	-1.11175179248721
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1565	56/9376	0.641898676403469	CCND1/CCND2/PRKACB/PRKACA/SMURF2/CDON	-1.20304389564405
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1565	79/9376	0.682525174910017	SLC18A3/AP2S1/ATP6V0C/ATP6V1B2/SLC1A1/VAMP2/ATP6V1F/UNC13B/AP2A1	-1.2683552561737
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/1565	122/9376	0.736605038495784	CCND1/PFKP/ADIPOR2/PPP2CA/PPP2R2B/CD36/PPP2R5C/SCD5/PIK3R1/PFKM/HMGCR/CAB39L/AKT1S1/LEPR/PRKAA2	-1.31072662392913
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1565	115/9376	0.729345742464231	PLA2G4A/PRKACB/PRKACA/ALOX5/KRAS/HTR1B/PTGS2/CASP3/MAOB/ITPR1/TRPC1/GNAI3/PLCB2/HTR1F	-1.30714670195679
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1565	150/9376	0.758866879659212	WNT5A/CCND1/WNT2/FZD6/WNT10A/MET/WNT6/DDB2/GADD45G/FZD1/WNT11/GADD45B/KRAS/PIK3R1/MYC/LRP5/CDKN1B/CDKN1A/TGFBR1	-1.33255536066494
Human Diseases	Substance dependence	hsa05034	Alcoholism	25/1565	191/9376	0.784169412709299	TH/H3-3B/H2AJ/H3-3A/CALM2/MACROH2A1/PRKACB/CAMK4/H2BC12/H2AZ1/PRKACA/H2AZ2/CALM1/CAMKK1/H4C3/H2AC20/MACROH2A2/GRIN2B/PPP1CB/KRAS/MAOB/H2AC8/GNAI3/ATF2/H2BC11	-1.34889947618386
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1565	65/9376	0.645190464487589	KCNN4/KRAS/PIK3R1/ITPR1/TRPC1/GABBR1/PLCB2	-1.28482295794456
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1565	116/9376	0.723058279167126	PLA2G4A/PRKACB/PRKACA/PPP3R1/SLC1A1/GRIN2B/PPP3CC/GRM7/ITPR1/GLS/ADCY3/TRPC1/GNAI3/PLCB2	-1.34338773205714
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/1565	109/9376	0.714529413488877	CD40/CXCL8/IRF9/MAP2K3/IRF7/CCL3L1/JUN/STAT1/PIK3R1/MAPK13/CHUK/RELA/IL6	-1.34182081631394
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1565	15/9376	0.399403620873269	ST3GAL1	-1.04197357878303
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1565	43/9376	0.557307377962701	AGPAT2/ACAT2/DGAT1/CD36	-1.30231298003838
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1565	16/9376	0.37444089456869	ST3GAL1	-1.12093365104032
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/1565	91/9376	0.65835761682407	GABRP/PDE4D/PRKACB/PDE3A/PRKACA/PDE4B/ADCY3/GABBR1/GNAI3/PDE4A	-1.46585487284211
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1565	36/9376	0.499254526091587	POLD2/POLE3/RPA3	-1.34736212521424
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1565	17/9376	0.352414959594061	GGT5	-1.19617861802565
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1565	45/9376	0.532538161164359	ABCC2/ABCA12/ABCD3/ABCB7	-1.40694725184539
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1565	70/9376	0.599105431309904	MGST1/HSD11B1/GSTP1/GSTO2/HSD11B1L/PTGS2/SULT1A3	-1.50690945773193
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	17/1565	144/9376	0.707277245296415	CCND1/CXCL8/IL17RC/ADIPOR2/MAP2K3/CXCL2/ACOX1/FAS/SCD5/CASP3/C5/MAPK13/C5AR1/CHUK/RELA/IL6/PRKAA2	-1.5844528566972
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1565	217/9376	0.745430720984673	HSP90AB1/CCND1/MGST1/HSP90AA1/PRKACB/ADRB2/PRKACA/JUN/RPS6KA2/BCL6/CCND3/NOTCH2/STAT3/GSTO2/KRAS/PIK3R1/MYC/KPNB1/VEGFA/AHR/ADCY3/PTGES3/GNAI3/ATF2/JAG1/RELA/KPNA6	-1.6982488149876
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1565	56/9376	0.534915563669557	DAD1/SRD5A3/DPM3/MGAT2/TMEM258	-1.56245440945869
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1565	103/9376	0.639821334408635	PPP2CA/SAP18/EIF4A3/PPP2R2B/PPP1CB/PPP2R5C/PABPC1/GSPT2/SRRM1/RNPS1/ETF1	-1.64518960747952
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1565	48/9376	0.499254526091587	MGAM/PIK3R1/ATP1B1/PLCB2	-1.55680017857773
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	41/1565	323/9376	0.760474386492448	VIM/THBS1/CCND1/CCND2/CDK6/SERPINB5/HMGA2/TNC/CDKN2A/CDC25B/CD44/SPRY2/MET/EFNA5/PDGFA/BCL2L11/EZR/NOTCH2/STAT3/MMP16/PTEN/MARCKS/KRAS/SOCS1/PIK3R1/MYC/PTGS2/ZEB2/CASP3/ABL1/CRK/VEGFA/GLS/CCNG1/CDKN1B/CDKN1A/FOXP1/TP63/RHOA/EZH2/PDCD4	-1.96085939087543
NA	NA	hsa04081	Hormone signaling	26/1565	219/9376	0.711266722103083	AVPR1A/ADRA1B/GNA15/ADIPOR2/BMPR1A/RAMP1/PRKACB/PTHLH/PRL/ADRB2/PRKACA/GHR/SSTR1/NPR3/STAT3/UCN2/OXTR/PIK3R1/PENK/PRLR/ADCY3/LEPR/GNAI3/RHOA/PLCB2/THRA	-1.93522640844882
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1565	22/9376	0.272320650595411	MAOB	-1.52947435065344
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/1565	86/9376	0.557307377962701	SCNN1A/PRKACB/PRKACA/HTR1B/GABBR1/PLCB2/TAS2R20/HTR1F	-1.84600614724757
NA	NA	hsa04082	Neuroactive ligand signaling	23/1565	199/9376	0.692433413071749	GABRP/SLC18A3/TAC3/ADRA1B/PRKACB/CHAT/ACHE/ADRB2/PRKACA/P2RY2/SLC1A1/GRIN2B/HRH1/HTR1B/PENK/GRM7/OGFRL1/SLC17A9/ADCY3/GABBR1/GNAI3/PLCB2/HTR1F	-1.96293001526879
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1565	24/9376	0.249627263045793	HS3ST3B1	-1.64747908018384
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1565	36/9376	0.332836350727725	SORD/FGGY	-1.79514559629068
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	14/1565	138/9376	0.607788118720193	CALM2/PRKACB/SOCS3/PRKACA/PPP1R3F/CALM1/PPP1CB/KRAS/SOCS1/PIK3R1/CRK/PRKAR1B/PRKAR2A/PRKAA2	-2.07759456307468
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1565	26/9376	0.230425165888425	HES1	-1.75881927395388
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1565	38/9376	0.315318648057844	GNPDA2/GPI	-1.89296617310369
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1565	79/9376	0.455016783273345	MGST1/HSD11B1/GSTP1/GSTO2/HSD11B1L/AKR7A2	-2.17728233180626
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1565	41/9376	0.29224655185849	GABRP/GRIN2B	-2.03285429359393
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1565	31/9376	0.193259816551582	HSD17B14	-2.01379089916248
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/1565	37/9376	0.161920386840515	GPI	-2.28625906706427
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1565	73/9376	0.328276948662961	MGST1/GSTP1/GSTO2/MAOB	-2.57887125824189
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	40/1565	370/9376	0.647681547362059	GABRP/AVPR1A/EDN1/TAC3/LYPD6B/ADRA1B/EDN2/PRSS3/PRL/ADRB2/GZMA/P2RY2/GHR/SSTR1/GRIN2B/PTGFR/HRH1/UCN2/S1PR3/HTR1B/OXTR/NPFFR2/PENK/F2R/GRM7/OGFRL1/C5/GAL/FPR1/PRLR/PTAFR/NR3C1/GABBR1/LEPR/C5AR1/NPW/THRA/HTR1F/SLURP2/LTB4R	-3.09499371088391
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/1565	243/9376	0.542399978963699	HSPA1A/LSM5/BCAS2/SF3B5/U2AF1/EIF4A3/SF1/THOC7/SF3B6/HSPA8/SRSF2/PPIE/SNRPF/HNRNPM/PQBP1/SNRPD2/SYF2/SNRPB2/SF3A1/LSM4/ZMAT2/RP9	-3.23498248746303
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/1565	183/9376	0.327380017109237	NOP10/POP4/POP5/IMP3/TCOF1/PWP2/GAR1/RPP40/RAN/RPP25L	-4.112975956058
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1565	449/9376	0.133431053743854	CAMK2D/CALM2/OR2T2/OR2T11/OR2T10/PRKACB/OR2G6/PRKACA/CALM1/ADCY3	-8.42292658319251