category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	110/2748	203/9376	1.8488322900309	THBS1/EMP1/ITGB6/FLNB/CAPN2/LAMB3/LAMA3/ITGB4/FLNA/DIAPH1/LAMC1/CAV2/COL4A5/MYLK/ITGA2/MET/ITGAV/ITGA6/IGF1R/EMP2/ARHGAP5/ITGB1/LAMB2/FN1/PTK2/VCL/THBS3/CCND2/PPP1CB/FYN/ERBB2/COL1A2/LAMA5/PPP1R12B/SRC/VEGFA/COL4A6/EGFR/ARHGAP35/PIK3CA/SOS1/ROCK1/CCND1/RASGRF1/DOCK1/SOS2/PXN/GSK3B/RAP1A/PIP5K1A/LAMB4/ROCK2/PPP1R12A/XIAP/PDGFD/PIK3R1/ACTB/ITGB5/MAPK1/BRAF/MAPK8/LAMC2/SHC3/PDGFB/VAV2/PRKCA/VEGFB/ITGB8/TLN2/PAK2/COL1A1/ITGA3/LAMB1/PIP5K1B/CAV1/BIRC2/COL6A1/PPP1R12C/AKT2/RAF1/RAPGEF1/TNXB/COL9A3/COL6A2/SHC1/PIP5K1C/TNC/PIK3R3/BIRC3/EGF/COL4A4/PTEN/MAP2K1/MAPK10/MYL9/PIK3CB/LAMA2/MYL5/ITGB7/RAP1B/ELK1/VTN/VWF/COL6A3/COL4A2/PDGFRA/ITGB3/ACTG1/ITGA1/RHOA	7.87257790005027
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	128/2748	250/9376	1.74691120815138	ASAP2/NEDD4L/CAV2/EHD2/AGAP1/KIF5B/RAB11FIP1/IGF1R/RAB22A/ARAP2/ASAP1/TGFBR2/PLD1/EPN2/CLTB/SRC/EGFR/SMURF1/LDLR/PDCD6IP/ARFGAP3/ACAP2/ARFGEF1/ACAP3/STAM/VPS37B/GBF1/RAB11FIP5/SMAD2/PIP5K1A/SMURF2/RAB5B/ARFGEF2/EEA1/WWP1/EPS15/TGFBR1/IGF2R/AP2B1/CHMP4C/WASHC4/SMAP1/ZFYVE9/FOLR3/CYTH2/SNX12/ARAP1/ARF6/CBLB/PSD4/WIPF2/RAB10/CHMP2B/CYTH3/NEDD4/DNM2/SMAD3/RAB5A/HGS/WASL/CLTC/USP8/RUFY2/VPS4B/STAM2/PIP5K1B/ZFYVE27/CAV1/GIT2/FGFR2/VPS37C/PARD6B/TRAF6/RBSN/EPN3/WASHC2A/EHD4/CAPZA2/ITCH/SH3GLB1/IST1/WASHC2C/ACTR3/WASHC5/WASHC1/CHMP1B/CBLC/DNAJC6/PIP5KL1/GRK4/RABEP1/CYTH1/ARFGAP1/RAB7A/ZFYVE16/SH3GLB2/ACTR2/SH3GL1/PIP5K1C/CHMP3/PRKCI/WASHC3/FGFR3/ACTR3C/AGAP9/EHD1/PARD3/AGAP3/RNF103-CHMP3/VPS37A/VPS45/SPART/RAB11FIP2/VPS26B/ARF1/RNF41/GRK2/IQSEC2/CHMP7/ARF5/DNM3/ARAP3/PDGFRA/MDM2/PSD/SNX32/RHOA/HLA-C	7.7072864645306
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	108/2748	204/9376	1.80631903416388	THBS1/LUM/DCN/FLNA/IQGAP1/WNT5A/RRAS/CAV2/WNT2/CAMK2D/ITGA2/ITPR3/EZR/MET/ITGAV/SDC4/IGF1R/TIAM1/HIF1A/ITGB1/IGF2/GAB1/FN1/PTK2/ARHGEF12/SDC1/GPC1/ANK3/PPP1CB/ANK2/ERBB2/COL1A2/TIMP3/PPP1R12B/SRC/VEGFA/EGFR/FZD6/PIK3CA/SOS1/ROCK1/CCND1/HSPG2/FRS2/WNT11/SOS2/PXN/WNT2B/SMAD2/WNT7A/FZD1/ROCK2/PPP1R12A/PIK3R1/ACTB/RDX/ITGB5/MAPK1/ERBB3/PTPN11/BRAF/VAV2/CDKN1A/PRKCA/MTOR/DROSHA/RRAS2/STAT3/COL1A1/CAV1/SLC9A1/PPP1R12C/WNT10A/GPC3/NRAS/AKT2/WNT9A/RAF1/ITPR1/ARAF/FZD7/ITPR2/PIK3R3/ARHGEF1/PTCH1/WNT6/HPSE/CD63/MAP2K1/PLAU/CTSL/PRKACB/TWIST1/PIK3CB/ELK1/PLCE1/VTN/ANK1/SDC2/ITGB3/MDM2/FZD8/PLCG1/ACTG1/WNT5B/RHOA/MMP2/CD44	7.49709001297835
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	156/2748	333/9376	1.59838441061148	THBS1/ITGB6/LAMB3/LAMA3/ITGB4/WNT5A/LLGL2/LAMC1/PATJ/CDK6/WNT2/COL4A5/ITGA2/ITGAV/PPP2R3A/ITGA6/ITGB1/UBR4/LAMB2/FN1/PTK2/THBS3/CCND2/ATP6AP1/DVL1/MAML2/CREB3L2/COL1A2/DLG1/LAMA5/PTGS2/RBL2/VEGFA/COL4A6/EGFR/APC/FZD6/PIK3CA/SOS1/ATP6V0A1/CCND1/WNT11/SOS2/IFNAR1/JAK1/PXN/WNT2B/MAGI1/GSK3B/PPP2R2A/TNFRSF1A/LAMB4/NFX1/WNT7A/EP300/CREBBP/FZD1/PPP2R5E/TSC2/NOTCH2/PPP2R5C/UBE3A/PIK3R1/ITGB5/MAPK1/LAMC2/PSEN1/ATP6V1A/RFNG/PPP2R5B/ATR/CHD4/TCIRG1/AXIN1/CDKN1A/CSNK1A1/MAML3/MTOR/ITGB8/PPP2R2B/PPP2CB/COL1A1/ITGA3/JAG1/LAMB1/ATM/TRAF3/PPP2R2D/STAT1/COL6A1/PARD6B/CREB5/PKM/WNT10A/PPP2R5A/NRAS/PALS1/RELA/PPP2R1A/EIF4EBP1/CREB1/AKT2/WNT9A/RAF1/CREB3/DLG2/TNXB/COL9A3/COL6A2/FZD7/IKBKB/TNC/TCF7L1/PRKCI/STAT2/TSC1/PIK3R3/PARD3/TRADD/PPP2R5D/ATP6V0B/WNT6/CHUK/EGF/COL4A4/PTEN/TBK1/MAP2K1/TUBG2/PRKACB/ATP6V0A2/NOTCH3/HES4/EIF2AK2/TCF7/PIK3CB/PPP2R1B/LAMA2/ITGB7/HES2/VTN/VWF/TYK2/COL6A3/FOXO1/NOTCH1/COL4A2/TICAM1/ITGB3/MDM2/HES1/RBL1/FZD8/WNT5B/ITGA1/HLA-C	7.15894250326855
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	59/2748	93/9376	2.16456151883677	LMO7/ARHGAP29/IQGAP1/NECTIN4/HEG1/MET/IGF1R/AFDN/TGFBR2/VCL/CDH1/FER/PTPRM/PTPRF/FYN/SNAI2/ERBB2/SRC/EGFR/SMURF1/ROCK1/RAP1A/BAIAP2/SMURF2/CTNNA1/EP300/CREBBP/ROCK2/TGFBR1/NECTIN3/ACTB/MAPK1/INSR/SMAD3/PTPRJ/WASL/FARP2/CTNND1/NLK/KRIT1/YES1/WASF3/RASIP1/CSNK2A1/SMAD4/TCF7L1/PARD3/NECTIN2/MYL9/TCF7/CCM2/MYL5/RAP1B/PTPRB/CTNNA3/CDH5/ACTG1/SORBS1/RHOA	7.2671225993058
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	61/2748	98/9376	2.1237560526394	PLCD1/ITPR3/BPNT2/DGKB/PI4KA/PIK3CA/PPIP5K2/INPP4B/MTMR3/CDS1/PIP5K1A/ITPKC/MTM1/PLCD3/PIK3R1/DGKA/MTMR2/PIK3C2A/SACM1L/PIK3C3/IP6K1/INPPL1/DGKH/PRKCA/PIKFYVE/IPMK/PI4KB/PIP5K1B/MTMR1/INPP5F/OCRL/PIK3C2B/PIP4K2C/MTMR6/CDIPT/PLCB4/MTMR4/ITPKB/CALM2/ITPR1/CDS2/PIP4K2A/PIP5K1C/ITPR2/PIK3C2G/PIK3R3/INPP4A/PLCB1/DGKI/DGKE/PTEN/PLCB3/PIK3CB/PPIP5K1/PLCE1/CALM1/IPPK/MTMR7/INPP5A/PLCG1/DGKQ	7.20046676500968
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	75/2748	142/9376	1.80207884863768	NEDD4L/FBXO2/HUWE1/MID1/PIAS1/BIRC6/UBE3C/UBE2E2/UBA1/SMURF1/TRIP12/UBR5/FBXW11/CUL4A/HERC4/PRKN/HERC1/STUB1/SMURF2/UBE4B/PIAS3/WWP1/COP1/CUL4B/BTRC/UBE2E3/XIAP/UBE3A/UBA6/UBE4A/UBE2Q1/CUL7/FBXW7/UBE2G1/CBLB/MAP3K1/SYVN1/UBE2B/NEDD4/UBC/DDB2/CDC27/FBXW8/UBE3B/UBE2W/CUL5/RHOBTB2/UBE2Q2/WWP2/CDC16/CUL3/BIRC2/TRAF6/PPIL2/ANAPC1/ITCH/KLHL9/CUL2/CBLC/FZR1/KEAP1/CUL1/MGRN1/BIRC3/PIAS2/UBE2J1/BIRC7/UBE2K/BRCA1/UBE2D3/UBE2O/SOCS3/TRIM32/MDM2/NHLRC1	6.20110454836451
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	81/2748	157/9376	1.76029816705143	WNT5A/LLGL2/PATJ/CCN2/WNT2/AREG/TEAD1/YWHAZ/WWTR1/TGFBR2/YAP1/CDH1/BMPR2/CCND2/PPP1CB/DVL1/SNAI2/BMPR1A/DLG1/APC/FZD6/CCND1/FBXW11/WNT11/STK3/LATS2/WNT2B/GSK3B/SMAD2/PPP2R2A/CTNNA1/WNT7A/FZD1/LATS1/BTRC/TGFBR1/ACTB/TP53BP2/AXIN1/YWHAQ/SMAD3/SAV1/BMP2/PPP2R2B/PPP2CB/BMPR1B/PPP2R2D/SERPINE1/BIRC2/PARD6B/WNT10A/PALS1/SMAD1/PPP2R1A/WNT9A/WWC1/DLG2/NF2/FZD7/SMAD4/TCF7L1/PRKCI/CSNK1E/MOB1A/WTIP/PARD3/YWHAG/BIRC3/WNT6/SMAD7/TCF7/MOB1B/TPTEP2-CSNK1E/PPP2R1B/CTNNA3/BMP6/ID1/FZD8/BMP5/ACTG1/WNT5B	6.18578206026917
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	87/2748	174/9376	1.70596797671033	CAPN2/CRYAB/FBXO2/ERO1A/MARCHF6/SEC31A/MAN1A2/DNAJC3/SEC62/MBTPS1/SEC23A/DNAJB2/SEC63/SEC24B/CKAP4/WFS1/DNAJC1/SEL1L/PRKN/ATF6/SAR1B/AMFR/EIF2AK3/MAN1B1/MAGT1/HSP90B1/STUB1/ATF4/UBE4B/SSR1/SEC24D/UGGT2/SELENOS/KRTCAP2/MAPK8/EDEM3/GANAB/OS9/UBE2G1/UGGT1/MBTPS2/TRAM1/SYVN1/SIL1/ATXN3/NPLOC4/EDEM1/UBXN6/PPP1R15A/MAP2K7/RNF185/SEC24A/DNAJC10/SEC61A1/HSPA5/SEC24C/STT3B/RPN1/LMAN1/DAD1/YOD1/DNAJC5/MAP3K5/ERN1/MOGS/DERL1/SSR4/FBXO6/ERLEC1/UBQLN1/STT3A/CUL1/HERPUD1/XBP1/UBQLN2/UBXN2A/SEC61A2/SSR3/UBE2J1/UBQLN4/UBE2D3/BCAP29/MAPK10/DDIT3/DUS4L-BCAP29/SEC31B/ERO1B	6.05231138253741
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	85/2748	169/9376	1.71606246177963	DAPK1/RRAS/OPTN/IGF1R/RB1CC1/HIF1A/IRS2/BIRC6/WDFY3/ULK1/ATG9B/PIK3CA/BCL2L1/LAMP1/RPTOR/MTMR3/MAP1LC3A/EIF2AK3/TAX1BP1/NBR1/VPS41/TSC2/RUBCN/PIK3R1/EPG5/MAPK1/ATG7/MAPK8/ULK2/WDR41/PIK3C3/ATG13/MTOR/CTSD/ZFYVE1/UBC/PRKAA1/LAMP2/ATG16L2/RRAS2/ATG14/DDIT4/ATG10/ATG2B/CFLAR/PIK3R4/PPP2CB/RRAGB/EIF2AK4/BECN1/STX7/TRAF6/NRAS/MTMR4/SH3GLB1/VPS39/SUPT20H/WDR45/AKT2/RAF1/ATG4B/ERN1/ITPR1/WIPI1/RAB7A/TSC1/PIK3R3/ATG4D/ATG12/RAB33B/PTEN/TBK1/MAP2K1/ATG2A/UVRAG/CTSL/PRKACB/MAPK10/DEPTOR/PIK3CB/WDR45B/VPS18/VPS16/PRKAA2/GORASP1	6.04836428838242
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	47/2748	78/9376	2.05591012577912	PLCD1/PI4KA/PIK3CA/PPIP5K2/INPP4B/MTMR3/PIP5K1A/ITPKC/MTM1/PLCD3/MTMR2/PIK3C2A/SACM1L/PIK3C3/IP6K1/INPPL1/PIKFYVE/IPMK/PI4KB/INPP5K/PIP5K1B/MTMR1/INPP5F/OCRL/PIK3C2B/PIP4K2C/MTMR6/CDIPT/PLCB4/MTMR4/ITPKB/PIP5KL1/PIP4K2A/PIP5K1C/PIK3C2G/INPP4A/PLCB1/PTEN/ALDH6A1/PLCB3/PIK3CB/PPIP5K1/PLCE1/IPPK/MTMR7/INPP5A/PLCG1	6.02951302357533
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	108/2748	233/9376	1.58149821016924	PLEC/THBS1/ITGB6/SPTBN1/FBN1/COL3A1/VIM/SUN1/DSG2/NEBL/PDLIM4/MYH14/DCN/ITGB4/DIAPH1/COL5A1/PDLIM5/DAAM1/JUP/DSC2/TMOD3/DSP/COL4A5/ITGA2/SPTAN1/ITGAV/NID2/ITGA6/SDC4/DIAPH2/ITGB1/TMEM43/TPM1/FN1/VCL/THBS3/SUN2/SYNE2/SDC1/ANK3/ANK2/SYNE1/COL1A2/COL4A6/HSPG2/FMNL2/COL5A2/INF2/AGRN/TNNT1/DAG1/MYH9/ATP1B1/SPTBN2/ATP1A1/LMNA/AMPD3/FBLN2/PKP2/ATP1A4/ACTB/ITGB5/SGCE/FBN2/ENO2/PDLIM7/ITGB8/TLN2/COL1A1/ITGA3/COL6A1/TRIM55/CAPZA2/SYNE3/ANKRD2/CSRP1/MYOM3/COL9A3/TNNT2/COL6A2/VCAN/DMD/MYOM1/SGCZ/FLNC/FHL1/COL4A4/DIAPH3/ANKRD23/SDC3/SNTB2/TNNC2/MYL9/ANKRD1/LAMA2/MYL5/ITGB7/OBSCN/COL6A3/SDC2/COL4A2/TPM2/ITGB3/NEB/ACTG1/LMOD1/ITGA1/NID1	5.78741646453655
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	106/2748	232/9376	1.55890177182151	ITGB6/RGCC/GSN/MYH14/ITGB4/NCKAP1/IQGAP1/DIAPH1/RRAS/MYLK/TMSB4X/ITGA2/EZR/ITGAV/ITGA6/TIAM1/DIAPH2/ITGB1/FN1/PTK2/VCL/ARHGEF12/PPP1CB/PPP1R12B/SRC/EGFR/APC/ARHGAP35/PIK3CA/SOS1/ROCK1/DOCK1/SOS2/MYH9/PXN/PIP5K1A/BAIAP2/ROCK2/PPP1R12A/ARHGEF7/PDGFD/PIK3R1/ACTB/RDX/ITGB5/MAPK1/SSH3/BRAF/PDGFB/PFN2/GNA13/VAV2/CYFIP1/SSH1/PIKFYVE/WASL/ITGB8/RRAS2/PAK2/SCIN/ITGA3/PIP5K1B/FGFR2/SLC9A1/PIP4K2C/PPP1R12C/NRAS/AKT2/RAF1/ACTR3/CFL2/PFN4/ARAF/PIP4K2A/ACTR2/PIP5K1C/CYRIA/C7/LIMK1/SSH2/PIK3R3/FGFR3/ACTR3C/ARHGEF1/FGF18/C5/BDKRB2/EGF/ABI2/DIAPH3/MAP2K1/MYL9/PIK3CB/FGD1/MYL5/ITGB7/CHRM5/LPAR2/PDGFRA/ITGB3/F2R/ARHGEF4/ACTG1/FGF7/ITGA1/RHOA	5.55027015636216
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	152/2748	362/9376	1.43263609093907	THBS1/ITGB6/LAMB3/LAMA3/ITGB4/LAMC1/CDK6/EREG/COL4A5/ITGA2/MET/AREG/ITGAV/PPP2R3A/ITGA6/EFNA5/IGF1R/YWHAZ/ITGB1/IGF2/LAMB2/FN1/PTK2/THBS3/CCND2/ERBB2/CREB3L2/COL1A2/LAMA5/RBL2/VEGFA/COL4A6/EGFR/GNB1/FOXO3/PIK3CA/SOS1/BCL2L1/CCND1/PKN2/SOS2/RPTOR/IFNAR1/JAK1/MAGI1/GSK3B/PPP2R2A/HSP90B1/ATF4/LAMB4/PPP2R5E/PRLR/TSC2/PPP2R5C/EPHA2/PDGFD/PIK3R1/ITGB5/JAK2/MAPK1/GNB5/ERBB3/LAMC2/PDGFB/INSR/NGF/PPP2R5B/CDKN1A/PRKCA/MAGI2/YWHAQ/MTOR/GYS1/VEGFB/GHR/ITGB8/OSMR/PRKAA1/DDIT4/PPP2R2B/PPP2CB/CSH1/COL1A1/ITGA3/LAMB1/PPP2R2D/FGFR2/COL6A1/MCL1/CREB5/PHLPP1/PPP2R5A/NRAS/RELA/PPP2R1A/EIF4EBP1/PHLPP2/CREB1/AKT2/RAF1/CREB3/RXRA/EFNA3/TNXB/COL9A3/ATF2/COL6A2/IKBKB/TNC/TSC1/PIK3R3/FGFR3/FGF18/PRL/GNGT1/YWHAG/PPP2R5D/C8orf44-SGK3/CHUK/EGF/COL4A4/PTEN/CSHL1/BRCA1/MAP2K1/SGK1/CRTC2/THEM4/GNB2/PIK3CB/PPP2R1B/LAMA2/BDNF/ITGB7/NTF3/PRKAA2/VTN/VWF/LPAR2/IL7/COL6A3/COL4A2/PDGFRA/ITGB3/MDM2/F2R/MTCP1/BCL2L11/KITLG/CSH2/FGF7/ITGA1	5.40531498576236
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	130/2748	300/9376	1.47850557981562	FLNA/PPP3CA/RRAS/EREG/MET/AREG/EFNA5/IGF1R/IGF2/PLA2G4A/TGFBR2/MAP3K2/ERBB2/MAP2K4/TAOK1/RAPGEF2/PPP3CC/VEGFA/EGFR/SOS1/MAP4K4/DUSP7/RASGRF1/CDC25B/FOS/SOS2/STK3/GADD45A/TAB2/RASA2/RAP1A/RPS6KA5/DUSP10/RPS6KA2/MAP4K3/TNFRSF1A/ATF4/ELK4/NF1/TAOK3/DUSP1/STK4/PPM1A/IL1R1/TGFBR1/EPHA2/PDGFD/MAPK1/MAPKAPK3/ERBB3/DUSP4/BRAF/MAPK8/PDGFB/PPP3CB/INSR/RPS6KA3/NGF/MAP3K1/MAPK8IP3/IL1RAP/PRKCA/JUND/VEGFB/CACNA2D3/RRAS2/MAP3K3/IRAK4/MAP2K7/PAK2/MAP2K5/TAOK2/MAP3K14/MKNK2/FGFR2/DUSP3/NFATC3/GADD45B/TRAF6/RPS6KA6/PTPRR/CACNG4/MAP3K6/NRAS/MAP3K9/NLK/RELA/AKT2/RAF1/RASGRF2/RPS6KA4/MAP3K5/NFATC1/EFNA3/ARAF/ATF2/IKBKB/IRAK1/MAP3K21/MAPKAPK2/FGFR3/MAPKAPK5/FGF18/TRADD/CHUK/EGF/SRF/HSPB1/NFKB2/MAP3K13/MAP2K1/PRKACB/MAPK10/MAPK7/DDIT3/BDNF/RAP1B/NTF3/ELK1/MAP4K2/CACNB3/PPM1B/MYD88/IL1A/PDGFRA/RASGRP1/MAP3K10/KITLG/FGF7/CACNB2	5.42379345506695
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	35/2748	56/9376	2.13245997088792	CCND2/SPOPL/SMURF1/CCND1/FBXW11/GSK3B/SMURF2/KIF3A/BTRC/CDON/CSNK1A1/IQCE/EVC/CSNK1G3/CUL3/SPOP/EVC2/MOSMO/MEGF8/CSNK1E/PTCH2/CUL1/MGRN1/PTCH1/CSNK1G1/EFCAB7/SUFU/PRKACB/GPR161/LRP2/CSNK1G2/GRK2/TPTEP2-CSNK1E/KIF7/GAS1	5.47282636711827
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	110/2748	248/9376	1.51335868901723	AHNAK/AHNAK2/FLNA/NCKAP1/MYO6/RRAS/DYNC1H1/TUBA4A/KLC3/S100A10/KIF5B/ANXA2/TUBA1A/MAP2K4/KLC1/EXOC4/TAB3/SNX33/PIK3CA/TUBB6/DYNLT3/ARL8B/ABI1/GCC2/FOS/TAB2/ACBD3/HSP90B1/RAB5B/TNFRSF1A/VPS41/KPNA4/EXOC5/ROCK2/DCTN1/RIPK2/DYNC1LI2/ACTB/MAPK1/TUBB2A/MAPK8/SNX9/DYNC2H1/KPNA3/PIK3C2A/CYTH2/ARF6/DYNC1I2/PFN2/PIK3C3/CYFIP1/CYTH3/DNM2/RAB5A/WASL/KPNA1/FYCO1/IRAK4/MAP2K7/RHOB/EXOC2/ACTR10/BIRC2/RIPK1/TRAF6/PIK3C2B/PLEKHM2/RELA/VPS39/EXOC7/RALA/AKT2/RAF1/ELMO2/ACTR3/PFN4/WASF3/CYTH1/RAB9A/RAB7A/IKBKB/ACTR2/IRAK1/PIK3C2G/TCF7L1/NOD1/ACTR3C/TRADD/BIRC3/STX10/ACTR1B/CHUK/TIRAP/KLC4/ARF1/MAP2K1/MAPK10/DYNLT1/MYL9/TCF7/PIK3CB/VPS18/KLC2/MYL5/VPS16/FHOD1/MYD88/PODXL/ACTG1/RHOA	5.27547652015077
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	73/2748	149/9376	1.67161962818597	RRAS/AVPR1A/GAB1/PLA2G4A/PLD1/DGKB/GAB2/FYN/AGPAT2/ADCY7/RALB/EGFR/PIK3CA/SOS1/PLPP2/RALGDS/SOS2/PIP5K1A/ADCY9/TSC2/PDGFD/PIK3R1/MAPK1/PTPN11/DGKA/SHC3/PDGFB/PLPP1/CYTH2/INSR/ARF6/GNA13/AGPAT3/CYTH3/DNM2/DGKH/PRKCA/MTOR/RRAS2/PTGFR/PIP5K1B/PLCB4/NRAS/PLPP3/RALA/AKT2/RAF1/CYTH1/SHC1/PIP5K1C/ADCY6/TSC1/PIK3R3/PTK2B/RAPGEF4/PLCB1/DGKI/DGKE/EGF/ARF1/MAP2K1/ADCY3/SPHK2/PLCB3/PIK3CB/DNM3/LPAR2/PDGFRA/F2R/PLCG1/KITLG/RHOA/DGKQ	5.32094789801863
NA	NA	hsa04519	Cadherin signaling	165/2748	404/9376	1.39348869384755	KRT6A/KRT24/KRT17/KRT14/DSC3/VIM/DSG2/KRT5/DSG1/NCKAP1/WNT5A/DAAM1/JUP/MYO1E/RRAS/DSC2/DSP/PKP1/FAT1/WNT2/PCDH7/GABRP/MET/KRT16/TEAD1/IGF1R/YWHAZ/AFDN/ADAM10/GJA1/WWTR1/KRT19/ERBIN/PTK2/YAP1/VCL/LIMA1/CDH1/PCDH9/MYO1D/AMOTL1/PPP1CB/PKP3/CELSR1/DVL1/ERBB2/TAOK1/AMOTL2/EGFR/APC/ARHGAP35/FZD6/SHOC2/ROCK1/CDH11/KRT13/KRT8/PCDH1/WNT11/PRICKLE1/STK3/LATS2/WNT2B/GSK3B/LHFPL6/KRT6C/KRT15/LHFPL2/MYO1C/CTNNA1/DSG3/TAOK3/WNT7A/EP300/CREBBP/FZD1/CDH10/ROCK2/LATS1/PKP2/ACTB/MAPK1/RERE/RYK/MAPK8/PSEN1/KRT78/TMC6/VAV2/CYFIP1/AXIN1/YWHAQ/VANGL1/CSNK1A1/SAV1/CELSR2/APH1B/ANKRD6/GABRB1/RRAS2/CTNND1/PCDHGA10/TAOK2/NCSTN/MPDZ/CDH2/KRT6B/TMC1/KRT27/WNT10A/NRAS/PALS1/RELA/WNT9A/RAF1/ACTR3/MYO1B/WWC1/NF2/PCDH11X/FZD7/GABRA4/IKBKB/ACTR2/TCF7L1/GABRB3/DSC1/MOB1A/CDH16/GABRE/WTIP/ACTR3C/PTK2B/PRICKLE2/YWHAG/KRT72/CDH23/LHFPL5/CDH26/WNT6/CHUK/LRP5/ABI2/MAP2K1/FAT3/KRT86/MAPK10/TMC7/PCDHGB6/TCF7/FAT4/MOB1B/KRT80/PCDH11Y/CTNNA3/GABRR2/CDH5/PDGFRA/PCDHGB5/FZD8/ACTG1/WNT5B/PCDHGC3/LHFPL3/RHOA	5.20572306684099
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	62/2748	122/9376	1.73393466485313	PFKP/PLCD1/KAT2B/ITGAV/HIF1A/NCOA1/THRB/SRC/SLC2A1/PIK3CA/MED13L/CCND1/NCOA2/MED13/ATP1B1/GSK3B/ATP2A2/ATP1A1/NCOR1/EP300/CREBBP/TSC2/NOTCH2/PLCD3/ATP1A4/PIK3R1/ACTB/MAPK1/PRKCA/MTOR/MED14/RCAN1/THRA/STAT1/MED1/SLC9A1/PLCB4/NRAS/AKT2/RAF1/RXRA/SIN3A/PIK3R3/MED24/NCOA3/PLCB1/SLC16A2/MAP2K1/DIO3/DIO1/PRKACB/NOTCH3/PLCB3/PIK3CB/PFKM/PLCE1/FOXO1/NOTCH1/ITGB3/MDM2/PLCG1/ACTG1	5.25382158977707
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	52/2748	99/9376	1.79212797553409	HIF1A/PLA2G4A/SLC44A2/PLD1/DGKB/EGFR/PIK3CA/SOS1/PLPP2/RALGDS/FOS/SOS2/PIP5K1A/TSC2/PCYT1A/PDGFD/PIK3R1/MAPK1/DGKA/MAPK8/PDGFB/PLPP1/DGKH/PRKCA/MTOR/SLC44A1/SLC22A5/SLC44A3/PIP5K1B/NRAS/PLPP3/EIF4EBP1/AKT2/RAF1/WASF3/GPCPD1/SP1/SLC44A5/PIP5K1C/TSC1/PIK3R3/SLC22A4/DGKI/DGKE/EGF/MAP2K1/MAPK10/PIK3CB/SLC22A3/PDGFRA/PLCG1/DGKQ	5.10166483199391
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	67/2748	138/9376	1.65651962955931	IRS2/TRIP10/PPP1CB/PTPRF/PYGL/PIK3CA/SOS1/PHKA1/SOS2/RPTOR/GSK3B/TSC2/HK2/PIK3R1/MAPK1/PHKA2/PYGB/BRAF/MAPK8/SHC3/INSR/CBLB/INPPL1/PHKB/FASN/PRKAG2/MTOR/GYS1/SOCS4/PRKAA1/PRKAR2A/MKNK2/PRKAB2/NRAS/PRKAR2B/HK1/EIF4EBP1/EXOC7/PRKAR1A/AKT2/RAF1/CALM2/RAPGEF1/ARAF/SREBF1/SHC1/IKBKB/RHOQ/PRKCI/PPP1R3F/TSC1/ACACB/PIK3R3/PRKAR1B/MAP2K1/PRKACB/PPP1R3E/MAPK10/SOCS3/PIK3CB/ELK1/PRKAA2/CALM1/FOXO1/INPP5A/PHKG1/SORBS1	5.00266051807946
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	44/2748	80/9376	1.87656477438137	GAS6/MET/IGF1R/GAB1/ERBB2/SRC/VEGFA/EGFR/FOXO3/PIK3CA/SOS1/BCL2L1/SOS2/JAK1/GSK3B/NF1/PDGFD/PIK3R1/JAK2/MAPK1/ERBB3/BRAF/SHC3/PDGFB/PRKCA/MTOR/STAT3/FGFR2/NRAS/EIF4EBP1/AKT2/RAF1/ARAF/SHC1/PIK3R3/FGFR3/AXL/EGF/PTEN/MAP2K1/PIK3CB/PDGFRA/PLCG1/BCL2L11	5.06971683233854
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	60/2748	120/9376	1.70596797671033	CAMK2D/SORT1/GAB1/FOXO3/PIK3CA/SOS1/ARHGDIB/KIDINS220/FRS2/SOS2/GSK3B/RAP1A/RPS6KA5/RPS6KA2/ATF4/NTRK3/PRDM4/PIK3R1/RIPK2/MAPK1/PTPN11/BRAF/MAPK8/PSEN1/SHC3/RPS6KA3/NGF/MAP3K1/MAP3K3/IRAK4/MAP2K7/ARHGDIA/MAP2K5/TRAF6/RPS6KA6/NRAS/ZNF274/RELA/AKT2/RAF1/MAP3K5/CALM2/RAPGEF1/SHC1/IKBKB/IRAK1/MAPKAPK2/ABL1/PIK3R3/MAP2K1/SH2B1/MAPK10/MAPK7/PIK3CB/BDNF/RAP1B/NTF3/CALM1/PLCG1/RHOA	5.01148810774373
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	65/2748	133/9376	1.66748749603266	IGF1R/IRS2/TGFBR2/CCND2/RBL2/CDKN2B/EGFR/FOXO3/PIK3CA/SOS1/CCND1/CCNG2/SOS2/GADD45A/SETD7/EP300/CREBBP/STK4/TGFBR1/PLK3/PIK3R1/MAPK1/BRAF/MAPK8/INSR/CDKN1A/HOMER3/SMAD3/PRKAG2/PRKAA1/STAT3/USP7/PLK2/ATM/GADD45B/PRKAB2/NRAS/NLK/AKT2/RAF1/FBXO25/SIRT1/ARAF/SMAD4/IKBKB/CDKN2D/CSNK1E/PIK3R3/ATG12/C8orf44-SGK3/CHUK/EGF/PTEN/MAP2K1/SGK1/MAPK10/PIK3CB/TPTEP2-CSNK1E/HOMER1/PRKAA2/FOXO1/HOMER2/MDM2/FBXO32/BCL2L11	4.99189257735949
NA	NA	hsa04518	Integrin signaling	73/2748	154/9376	1.61734626363447	THBS1/ITGB6/FLNB/FBN1/LAMB3/LAMA3/ITGB4/FLNA/LAMC1/COL4A5/ITGA2/MET/ITGAV/ITGA6/IGF1R/ITGB1/LAMB2/FN1/PTK2/VCL/THBS3/CDH1/CCND2/ERBB2/COL1A2/LAMA5/SRC/VEGFA/COL4A6/EGFR/PIK3CA/CCND1/PXN/GSK3B/LAMB4/PDGFD/PIK3R1/ACTB/ITGB5/LAMC2/PDGFB/LIMS1/MTOR/VEGFB/ITGB8/TLN2/COL1A1/ITGA3/LAMB1/COL6A1/AKT2/TNXB/COL9A3/COL6A2/TNC/PIK3R3/FERMT2/FERMT1/EGF/COL4A4/PIK3CB/LAMA2/ITGB7/VTN/VWF/COL6A3/COL4A2/PDGFRA/ITGB3/ACTG1/FREM2/ITGA1/NPNT	4.9736976149027
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	56/2748	110/9376	1.73698557628689	THBS1/FBN1/LTBP1/DCN/EMP3/ID4/THSD4/ACVR2A/TGFBR2/NOG/BMPR2/BMPR1A/CDKN2B/NBL1/SMURF1/ROCK1/SKIL/SKI/SMAD2/SMURF2/NCOR1/EP300/CREBBP/TGFBR1/MAPK1/ZFYVE9/LEMD3/SMAD3/BMP2/PPP2CB/BMPR1B/NEO1/SMAD5/ACVR2B/SMAD1/PPP2R1A/HFE/SP1/FST/ZFYVE16/SMAD4/SIN3A/TFR2/CUL1/TMEM53/INHBB/SMAD7/IGSF1/RGMB/PPP2R1B/BMP6/ID1/RBL1/BMP5/ACVR1B/RHOA	5.00624310670284
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	54/2748	105/9376	1.75470991890206	RRAS/OPTN/HUWE1/HIF1A/PINK1/ULK1/CITED2/ATG9B/SRC/FOXO3/BCL2L1/SMURF1/BNIP3L/PRKN/MAP1LC3A/AMFR/ARIH1/EIF2AK3/TAX1BP1/NBR1/SMURF2/RAB5B/ATF4/TBC1D15/USP15/MAPK8/TBC1D17/RAB5A/OPA1/UBC/USP8/TFE3/RRAS2/RABGEF1/MFN2/BECN1/RHOT1/NLRX1/MFN1/NRAS/MARCHF5/RELA/SP1/CSNK2A1/RAB7A/MON1B/MTX3/USP30/TBK1/BCL2L13/FKBP8/MAPK10/CCZ1B/MON1A	5.00742172636572
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	49/2748	93/9376	1.79768668513562	LAMB3/LAMA3/LAMC1/CDK6/COL4A5/ITGA2/ITGAV/ITGA6/ITGB1/LAMB2/FN1/PTK2/LAMA5/PTGS2/CDKN2B/COL4A6/PIK3CA/BCL2L1/CCND1/GADD45A/LAMB4/XIAP/PIK3R1/FHIT/LAMC2/POLK/CDKN1A/DDB2/ITGA3/LAMB1/TRAF3/BIRC2/GADD45B/TRAF6/RELA/AKT2/RXRA/IKBKB/PIK3R3/ZBTB17/BIRC3/CHUK/BIRC7/COL4A4/PTEN/PIK3CB/LAMA2/COL4A2/APAF1	4.97774213122263
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	47/2748	89/9376	1.80180887427833	THBS1/ITGB6/LAMB3/LAMA3/ITGB4/LAMC1/COL4A5/ITGA2/ITGAV/ITGA6/SDC4/ITGB1/LAMB2/FN1/THBS3/SDC1/COL1A2/LAMA5/COL4A6/HSPG2/AGRN/DAG1/LAMB4/ITGB5/LAMC2/ITGB8/COL1A1/ITGA3/LAMB1/COL6A1/TNXB/COL9A3/COL6A2/TNC/COL4A4/LAMA2/ITGB7/VTN/VWF/COL6A3/COL4A2/SV2B/ITGB3/FREM2/ITGA1/NPNT/CD44	4.89362731595131
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	81/2748	178/9376	1.55262254060154	WNT5A/DAAM1/PPP3CA/WNT2/CAMK2D/CCND2/CELSR1/DVL1/ROR2/TBL1XR1/CTBP2/LGR4/PPP3CC/APC/FZD6/CCND1/PORCN/NFATC2/FBXW11/WNT11/PRICKLE1/TLE4/WNT2B/GSK3B/DKK2/GPC4/TLE1/WNT7A/EP300/CREBBP/FZD1/SFRP2/ROCK2/DKK1/BTRC/LGR5/ROR1/RYK/MAPK8/PSEN1/APCDD1/PPP3CB/CHD8/SENP2/AXIN1/PRKCA/SMAD3/VANGL1/CSNK1A1/CELSR2/INVS/ANKRD6/NFATC3/LGR6/WNT10A/PLCB4/NLK/WNT9A/CTBP1/NFATC1/SIRT1/CSNK2A1/FOSL1/FZD7/SMAD4/TCF7L1/CSNK1E/CUL1/PRICKLE2/PLCB1/WNT6/LRP5/PRKACB/MAPK10/TCF7/PLCB3/TPTEP2-CSNK1E/MCC/FZD8/WNT5B/RHOA	4.79285892729689
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	42/2748	77/9376	1.86105597459309	CDK6/TGFBR2/PLD1/ERBB2/RALB/VEGFA/EGFR/PIK3CA/BCL2L1/RALGDS/CCND1/JAK1/GADD45A/SMAD2/TGFBR1/PIK3R1/MAPK1/BRAF/MAPK8/POLK/CDKN1A/SMAD3/MTOR/DDB2/STAT3/STAT1/GADD45B/RELA/RALBP1/RALA/AKT2/RAF1/ARAF/SMAD4/IKBKB/PIK3R3/CHUK/EGF/MAP2K1/MAPK10/BRCA2/PIK3CB	4.88496409286356
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	23/2748	34/9376	2.30807432143163	NPAS2/PER3/NR1D1/NR1D2/CLOCK/RORA/FBXW11/BHLHE40/PER2/FBXL3/BTRC/PRKAG2/PER1/CRY1/PRKAA1/CRY2/PRKAB2/CREB1/DBP/CSNK1E/CUL1/TPTEP2-CSNK1E/PRKAA2	4.9198821486033
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	106/2748	250/9376	1.44666084425036	SORT1/OSBPL1A/ASAH1/SUMF1/VPS13C/OSBPL3/SCARB2/ATP6AP1/CLTB/PSAP/SLC17A5/SMPD1/ABCA5/ATP6V0A1/HGSNAT/ARL8B/SPG11/NPC1/CTSA/LAMP1/RPTOR/AP1G1/LAPTM4A/VPS41/CTSZ/DMXL1/IGF2R/AP2B1/GNS/OSBPL5/VPS13A/AP3B1/OSBP/ARSA/ATP6V1A/MFSD8/ENTPD4/SLC29A3/ACP2/OSBPL2/AP3D1/TCIRG1/ABCA2/CTSF/NCOA7/PIKFYVE/SLC11A2/TPP1/MTOR/CTSD/GNPTAB/CLTC/TPCN1/CD164/OSBPL6/LAMP2/TFE3/WDR7/HYAL2/RRAGB/AP4E1/SLC15A4/IDS/GPR155/GALC/CLCN7/MEAK7/GNPTG/VPS39/ZFYVE26/SLC36A4/CTSV/AP3S1/SGSH/AP1G2/RAB7A/GALNS/ARSG/HYAL1/TTI1/FUCA2/AP4M1/BLOC1S1/ATP6V0B/NPC2/CTSW/GGA2/IDUA/OSTM1/CTSK/CD63/AP5B1/VPS26B/CTSL/ATP6V0A2/DEPTOR/MCOLN1/VPS18/GGA3/VPS16/GAA/HYAL4/ABCB9/AP3M2/HYAL3/AP4B1	4.6090392560141
NA	NA	hsa04382	Cornified envelope formation	94/2748	217/9376	1.47798147291034	DST/KRT6A/COL17A1/PLEC/KRT24/KRT17/KRT14/S100A4/SPRR3/LAMB3/PPL/DSG2/KRT5/EVPL/LAMA3/ITGB4/DSG1/S100A16/JUP/S100A14/COL7A1/DSP/PKP1/COL4A5/S100A6/S100A10/KRT16/PPP2R3A/ITGA6/TMEM79/KRT19/KDSR/SPTLC3/PKP3/PRSS8/LAMA5/COL4A6/KRT13/KRT8/S100A2/CLDN4/S100A3/KRT6C/PPP2R2A/KRT15/DSG3/PPP2R5E/ABCA12/PKP2/PPP2R5C/ELOVL1/LAMC2/CLDN1/KRT78/CLDN9/SPTLC1/PPP2R5B/OCLN/SPTLC2/ALOXE3/SPRR1A/PPP2R2B/PPP2CB/SPRR1B/PPP2R2D/KRT6B/KRT27/PPP2R5A/ABHD5/PPP2R1A/SLC27A1/CLDN12/PCSK6/CDSN/S100A8/CLDN15/DSC1/FURIN/SLC27A4/UGCG/KRT72/PPP2R5D/IVL/COL4A4/S100A5/KRT86/KAZN/PPP2R1B/KRT80/CASP14/CLDN3/CLDN6/COL4A2/SPRR2G	4.58690402457582
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	60/2748	125/9376	1.63772925764192	GNAQ/CERS6/SGMS2/PPP2R3A/ASAH1/SGMS1/PLD1/SPTLC3/GAB2/FYN/SMPD1/PIK3CA/ROCK1/PPP2R2A/TNFRSF1A/PPP2R5E/ROCK2/PPP2R5C/PIK3R1/MAPK1/MAPK8/GNA13/SPTLC1/PPP2R5B/PRKCA/SGPP2/ORMDL2/CTSD/SPTLC2/CERS5/PPP2R2B/NSMAF/PPP2CB/PPP2R2D/PPP2R5A/PLCB4/NRAS/RELA/PPP2R1A/AKT2/RAF1/ORMDL3/MAP3K5/SGPL1/S1PR3/PIK3R3/ACER2/TRADD/PPP2R5D/PLCB1/BDKRB2/PTEN/MAP2K1/MAPK10/SPHK2/PLCB3/PIK3CB/PPP2R1B/PRKCE/RHOA	4.62167881203558
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	76/2748	170/9376	1.52533607329395	WNT5A/CDK6/WNT2/MET/IGF1R/IGF2/GAB1/TGFBR2/GSTO2/ARID1B/DVL1/EGFR/APC/FZD6/PIK3CA/SOS1/BCL2L1/CCND1/WNT11/SOS2/GADD45A/WNT2B/GSK3B/SMAD2/WNT7A/FZD1/TXNRD2/PBRM1/TGFBR1/MGST1/PIK3R1/ACTB/ARID1A/MAPK1/BRAF/SMARCC2/ARID2/SHC3/SMARCA2/POLK/AXIN1/CDKN1A/PRKCA/SMAD3/CSNK1A1/MTOR/SMARCA4/NQO1/DDB2/GADD45B/WNT10A/NRAS/AKT2/WNT9A/RAF1/MGST2/ARAF/FZD7/SHC1/SMAD4/TCF7L1/KEAP1/PIK3R3/WNT6/LRP5/PTEN/MAP2K1/TCF7/PIK3CB/ELK1/SMARCD3/GSTM2/FZD8/PLCG1/ACTG1/WNT5B	4.45070645525866
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	58/2748	122/9376	1.62206791228196	IGFBP3/GNAQ/ITPR3/IRS2/PTK2/MAP2K4/CREB3L2/ADCY7/SSTR1/PIK3CA/SOS1/FOS/SOS2/GSK3B/ADCY9/ATF4/EP300/CREBBP/PIK3R1/JAK2/MAPK1/GNA11/MAPK8/SHC3/MAP3K1/JUNB/PRKCA/MTOR/GHR/STAT3/CSH1/STAT1/STAT5B/CREB5/PLCB4/NRAS/CREB1/AKT2/RAF1/CREB3/ITPR1/ATF2/SHC1/ADCY6/ITPR2/PIK3R3/PLCB1/CSHL1/MAP2K1/PRKACB/MAPK10/SOCS3/ADCY3/PLCB3/PIK3CB/ADCY10/PLCG1/CSH2	4.45303101810639
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	51/2748	104/9376	1.67316090023514	SGMS2/LPCAT2/MBOAT2/PLAAT2/PLA2G4A/SGMS1/PLD1/ACHE/ETNK2/DGKB/AGPAT2/PLPP2/LPGAT1/CDS1/PNPLA6/MBOAT1/TAFAZZIN/PCYT1A/PLB1/PLD3/DGKA/PLPP1/LPCAT4/SELENOI/LPIN3/LPIN1/PLA2G12A/GPD2/AGPAT3/DGKH/LCLAT1/GNPAT/CEPT1/GPAT4/CDIPT/PLPP3/LPIN2/GPCPD1/SAMD8/CDS2/PLA2G6/ETNK1/LCAT/DGKI/DGKE/PEMT/PNPLA7/GPAT3/DGKQ/GPAT2/PTDSS2	4.44479354388461
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	33/2748	59/9376	1.908370956998	CDH1/ERBB2/EGFR/APC/FOXO3/PIK3CA/SOS1/CCND1/SOS2/GADD45A/GSK3B/CTNNA1/PIK3R1/MAPK1/BRAF/POLK/AXIN1/CDKN1A/DDB2/GADD45B/NRAS/AKT2/RAF1/ARAF/TCF7L1/PIK3R3/EGF/PTEN/MAP2K1/TCF7/PIK3CB/ELK1/CTNNA3	4.50665124594188
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	71/2748	158/9376	1.53321172590423	WNT5A/CLIP1/WNT2/IGF1R/ULK1/CAB39/DVL1/FZD6/PIK3CA/SOS1/WNT11/SOS2/RPTOR/WNT2B/GSK3B/RPS6KA2/TNFRSF1A/WNT7A/FZD1/TSC2/RICTOR/PIK3R1/FNIP1/MAPK1/BRAF/ULK2/ATP6V1A/INSR/RPS6KA3/LPIN3/LPIN1/PRKCA/MTOR/PRKAA1/MAPKAP1/DDIT4/RRAGB/FNIP2/RPS6KA6/WNT10A/NRAS/EIF4EBP1/AKT2/WNT9A/RAF1/LPIN2/SLC7A5/MIOS/NPRL3/FZD7/IKBKB/TSC1/PIK3R3/TTI1/PRR5L/GRB10/DEPDC5/WNT6/CHUK/LRP5/PTEN/MAP2K1/SGK1/FLCN/DEPTOR/PIK3CB/PRKAA2/CASTOR2/FZD8/WNT5B/RHOA	4.35223799034256
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	44/2748	87/9376	1.72557680402884	EREG/AREG/TGFBR2/RALB/EGFR/APC/PIK3CA/SOS1/RALGDS/CCND1/FOS/SOS2/GADD45A/GSK3B/SMAD2/TGFBR1/PIK3R1/MAPK1/BRAF/MAPK8/POLK/APPL1/AXIN1/CDKN1A/SMAD3/MTOR/DDB2/MSH3/GADD45B/NRAS/RALA/AKT2/RAF1/ARAF/SMAD4/TCF7L1/PIK3R3/EGF/MAP2K1/MAPK10/TCF7/PIK3CB/BCL2L11/RHOA	4.37785413916417
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	75/2748	170/9376	1.50526586180324	MYH14/LLGL2/TUBA4A/PATJ/NEDD4L/EZR/AFDN/TIAM1/ITGB1/TUBA1A/AMOTL1/ERBB2/DLG1/RAPGEF2/F11R/AMOTL2/SRC/ROCK1/CCND1/CLDN4/MYH9/MAGI1/RAP1A/RUNX1/PPP2R2A/ROCK2/ACTB/RDX/MAPK8/CLDN1/MAP3K1/CLDN9/NEDD4/PRKAG2/OCLN/EPB41L4B/PRKAA1/MAP2K7/PPP2R2B/PPP2CB/PPP2R2D/MICALL2/MPDZ/CGN/PARD6B/ARHGEF18/PRKAB2/RAB8B/PALS1/PPP2R1A/ACTR3/SYMPK/CLDN12/MAP3K5/DLG2/NF2/ACTR2/YBX3/CLDN15/PRKCI/WHAMM/ACTR3C/PARD3/PRKACB/MAPK10/MYL9/PPP2R1B/CLDN3/TJAP1/PRKCE/PRKAA2/ARHGEF2/CLDN6/ACTG1/RHOA	4.28066936018538
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	80/2748	184/9376	1.48345041453073	WNT5A/SEMA3C/RHOD/PPP3CA/RRAS/SLIT2/ABLIM3/CAMK2D/NGEF/MET/EFNA5/ITGB1/SEMA5A/PTK2/EFNB2/PLXNB2/BMPR2/ARHGEF12/DPYSL2/FYN/SRGAP2/PLXNB1/PPP3CC/SRC/PIK3CA/ROCK1/EPHA4/PLXNA2/NFATC2/GSK3B/SEMA4D/ROCK2/EPHA2/PIK3R1/MAPK1/SSH3/PTPN11/RYK/ABLIM1/PPP3CB/PRKCA/SSH1/PLXNA3/PAK2/BMPR1B/NEO1/SRGAP1/NFATC3/NTN4/PARD6B/SLIT3/NRAS/SEMA3B/RAF1/RGS3/CFL2/LRIG2/PLXNA1/EFNA3/EPHB3/NTN1/LIMK1/SSH2/ABL1/PIK3R3/PARD3/PTCH1/TRPC1/ABLIM2/MYL9/PIK3CB/MYL5/ROBO2/SEMA3A/SEMA4F/ROBO1/PLCG1/WNT5B/RHOA/SEMA6D	4.26440646548807
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	70/2748	157/9376	1.52124532955062	CAPN2/IGFBP3/PPP3CA/RRAS/CDK6/ITPR3/TGFBR2/ZFP36L2/HIPK3/CCND2/PPP1CB/RBL2/PPP3CC/CDKN2B/FOXO3/PIK3CA/CCND1/TRPM7/HIPK2/NFATC2/FBXW11/GADD45A/SMAD2/RASSF5/TSC2/BTRC/TGFBR1/MCU/PIK3R1/HIPK1/ZFP36L1/MAPK1/NBN/PPP3CB/ATR/CDKN1A/SMAD3/MTOR/RRAS2/RAD9A/ATM/SERPINE1/NFATC3/GADD45B/NRAS/RELA/EIF4EBP1/AKT2/RAF1/ETS1/LIN54/CALM2/NFATC1/SIRT1/ITPR1/ITPR2/MAPKAPK2/TSC1/PIK3R3/LIN52/PTEN/MAP2K1/PIK3CB/TRAF3IP2/CALM1/FOXO1/IL1A/MDM2/RBL1/HLA-C	4.24084937760372
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	49/2748	101/9376	1.65529566057042	COL3A1/DIAPH1/F3/EDN1/COL4A5/PLCD1/THBD/FN1/TGFBR2/COL1A2/VEGFA/COL4A6/PIK3CA/CCND1/SMAD2/TGFBR1/PLCD3/PIK3R1/JAK2/MAPK1/MAPK8/PRKCA/SMAD3/VEGFB/STAT3/COL1A1/SERPINE1/STAT1/STAT5B/PLCB4/NRAS/RELA/AKT2/NFATC1/SMAD4/PIK3R3/PLCB1/COL4A4/MAPK10/PLCB3/PIM1/PIK3CB/PLCE1/PRKCE/FOXO1/IL1A/COL4A2/PLCG1/MMP2	4.26327917045082
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	39/2748	77/9376	1.7281234049793	CDK6/TGFBR2/GAB2/CTBP2/PIK3CA/SOS1/BCL2L1/CCND1/SOS2/GADD45A/RUNX1/TGFBR1/PIK3R1/MAPK1/PTPN11/BRAF/SHC3/POLK/CDKN1A/SMAD3/DDB2/GADD45B/STAT5B/NRAS/RELA/AKT2/RAF1/CTBP1/ARAF/SHC1/SMAD4/IKBKB/ABL1/PIK3R3/CHUK/MAP2K1/BCR/PIK3CB/MDM2	4.13080774473261
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	62/2748	138/9376	1.53289876168175	GNAQ/ITGB1/FN1/PTK2/ARHGEF12/MAP2K4/SRC/PIK3CA/ROCK1/PKN2/DOCK1/FOS/NFATC2/PXN/TAB2/GSK3B/PIP5K1A/BAIAP2/RPS6KA2/SKAP2/ROCK2/ARHGEF7/PIK3R1/ACTB/MAPK1/MAPK8/ARF6/RPS6KA3/WIPF2/VAV2/WASL/IRAK4/MAP2K7/PIP5K1B/GIT2/NFATC3/TRAF6/RPS6KA6/RELA/AKT2/ELMO2/ACTR3/NFATC1/IKBKB/ACTR2/PIP5K1C/IRAK1/LIMK1/PIK3R3/ACTR3C/PTK2B/ARHGEF1/CHUK/TBK1/MAP2K1/MAPK10/PIK3CB/MYD88/TICAM1/PLCG1/ACTG1/RHOA	4.06067309364112
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	71/2748	163/9376	1.48618069136729	YWHAZ/TGFBR2/ATP6AP1/MAP2K4/CREB3L2/SRC/PIK3CA/SOS1/HSPG2/FOS/NFATC2/SOS2/IFNAR1/JAK1/TAB2/ATF4/EP300/CREBBP/TGFBR1/PIK3R1/JAK2/MAPK1/BRAF/MAPK8/MAP3K1/CDKN1A/PRKCA/YWHAQ/SMAD3/DDB2/IRAK4/MAP2K7/STAT3/STAT6/IFIH1/TRAF3/STAT1/NFATC3/STAT5B/TRAF6/MAVS/CREB5/STAT4/NRAS/RELA/CREB1/AKT2/DDX3X/RAF1/CREB3/NFATC1/ARAF/ATF2/SMAD4/IKBKB/IRAK1/STAT2/PIK3R3/PTK2B/CHUK/SLC10A1/TIRAP/TBK1/MAP2K1/MAPK10/PIK3CB/ELK1/TYK2/MYD88/TICAM1/APAF1	4.03175121978565
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	56/2748	122/9376	1.56613453599637	PFKP/PPP2R3A/IGF1R/IRS2/SCD5/ULK1/CAB39/CREB3L2/ADIPOR1/FOXO3/PIK3CA/CCND1/HMGCR/RPTOR/PPP2R2A/LEPR/PPP2R5E/RAB2A/TSC2/PPP2R5C/PIK3R1/TBC1D1/INSR/PPP2R5B/RAB10/FASN/PRKAG2/MTOR/CPT1A/GYS1/PRKAA1/PPP2R2B/PPP2CB/PPP2R2D/SCD/CREB5/PRKAB2/PPP2R5A/PPP2R1A/EIF4EBP1/CREB1/AKT2/CREB3/SIRT1/SREBF1/TSC1/ACACB/PIK3R3/PPP2R5D/PFKFB4/CRTC2/PIK3CB/PPP2R1B/PFKM/PRKAA2/FOXO1	4.05263573227106
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	64/2748	144/9376	1.51641597929808	WNT5A/ID4/HAND1/WNT2/IGF1R/ACVR2A/ZFHX3/BMPR2/KLF4/MEIS1/DVL1/BMPR1A/APC/FZD6/PIK3CA/SKIL/WNT11/JAK1/WNT2B/GSK3B/SMAD2/RIF1/WNT7A/FZD1/PIK3R1/JAK2/MAPK1/AXIN1/SMAD3/KAT6A/STAT3/BMPR1B/SMAD5/BMI1/FGFR2/PCGF3/ACVR2B/WNT10A/NRAS/SMAD1/AKT2/WNT9A/SMARCAD1/RAF1/IL6ST/FZD7/LIFR/SMAD4/PIK3R3/FGFR3/TCF3/SETDB1/WNT6/JARID2/INHBB/MAP2K1/TCF7/PIK3CB/POU5F1B/ID1/FZD8/WNT5B/ACVR1B/LHX5	4.02101573610305
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	88/2748	212/9376	1.4162753014199	THBS1/GNAQ/RRAS/MET/EFNA5/IGF1R/AFDN/TIAM1/ITGB1/CDH1/ADCY7/RAPGEF2/RALB/SRC/VEGFA/EGFR/PIK3CA/RALGDS/MAGI1/RAP1A/ADCY9/RASSF5/EPHA2/PDGFD/PIK3R1/ACTB/MAPK1/BRAF/PDGFB/INSR/PFN2/NGF/VAV2/PRKCA/MAGI2/VEGFB/SIPA1L3/PRKD2/FARP2/CTNND1/TLN2/FGFR2/MAGI3/PARD6B/PLCB4/NRAS/KRIT1/RALA/AKT2/RAF1/PFN4/CALM2/RAPGEF1/EFNA3/SIPA1L1/ADCY6/PRKCI/PIK3R3/FGFR3/FGF18/PARD3/RAPGEF4/PLCB1/EGF/SIPA1L2/PRKD1/MAP2K1/ADCY3/PRKD3/RGS14/PLCB3/PIK3CB/RAP1B/PLCE1/LPAR2/RAP1GAP/CALM1/ARAP3/ID1/PDGFRA/ITGB3/F2R/ADORA2B/PLCG1/ACTG1/KITLG/FGF7/RHOA	3.94737863943623
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	53/2748	115/9376	1.57245743940257	AKAP13/GNAQ/ITPR3/PTHLH/OXSR1/PDE4D/PLD1/CREB3L2/ADCY7/EGFR/MEF2A/WNK1/FOS/GATA3/ADCY9/ATF4/MAFB/MAPK1/GNA11/BRAF/ARHGEF11/GNA13/RUNX2/CDKN1A/PRKCA/JUND/MEF2D/MMP24/CREB5/PLCB4/CREB1/RAF1/CREB3/STK39/SP1/RXRA/ITPR1/ARAF/ATF2/ADCY6/ITPR2/ARHGEF1/PLCB1/LRP5/WNK3/MAP2K1/SGK1/PRKACB/SLC12A3/ADCY3/PLCB3/MMP16/RHOA	3.977094718219
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	102/2748	253/9376	1.37556311165576	CAPN2/DIAPH1/PLCD1/ITPR3/CAST/ITGB1/PTK2/VCL/CAPNS1/TNIP1/SRC/EGFR/TAB3/FOXO3/PIK3CA/BCL2L1/ROCK1/DOCK1/FBXW11/RPTOR/FNBP1L/PXN/TAB2/MAP1LC3A/GSK3B/RPS6KA5/TNFRSF1A/ROCK2/IL1R1/BTRC/PLCD3/HK2/PIK3R1/RIPK2/ACTB/FNBP1/MAPK1/MAPK8/CYTH2/ARF6/PFN2/PIK3C3/SEPTIN8/CYTH3/H3-3B/MTOR/WASL/MALT1/UBC/ATG14/TLN2/SEPTIN9/PIK3R4/RRAGB/SEPTIN7/ATM/BECN1/RIPK1/TRAF6/PLCB4/HK1/RELA/AKT2/ELMO2/ACTR3/PFN4/UBE2V1/ITPR1/CYTH1/WIPI1/IKBKB/ACTR2/ITPR2/CUL1/PIK3R3/NOD1/UBE2V2/ACTR3C/TRADD/PLCB1/ATG12/CHUK/U2AF1L4/ARF1/SEPTIN2/TBK1/UBE2D3/MAPK10/MYL9/PLCB3/PIK3CB/MYL5/PLCE1/PRKCE/ARHGEF2/FOXO1/MYD88/MDM2/PLCG1/ACTG1/RHOA/CD44	3.89921429788252
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	42/2748	86/9376	1.66629430283335	EREG/CAMK2D/AREG/GAB1/PTK2/ABL2/ERBB2/MAP2K4/SRC/EGFR/PIK3CA/SOS1/SOS2/GSK3B/PIK3R1/MAPK1/ERBB3/BRAF/MAPK8/SHC3/CBLB/CDKN1A/PRKCA/MTOR/MAP2K7/PAK2/STAT5B/NRG4/NRAS/EIF4EBP1/AKT2/RAF1/ARAF/SHC1/ABL1/PIK3R3/EGF/MAP2K1/MAPK10/PIK3CB/ELK1/PLCG1	3.99677979298154
NA	NA	hsa04517	IgSF CAM signaling	117/2748	299/9376	1.33510537307765	SPTBN1/LMO7/MYH14/IQGAP1/NECTIN4/SLITRK6/TRIO/TUBA4A/SLIT2/MYLK/EZR/SPTAN1/AFDN/ITGB1/PTK2/VCL/CDH1/TUBA1A/ANK3/MBP/MAP2/PTPRF/ANK2/FYN/SRGAP2/RAPGEF2/F11R/SRC/IL1RAPL2/PIK3CA/TUBB6/PLXNA2/EPB41L2/MYH9/PXN/SPTBN2/MAGI1/GSK3B/RAP1A/BAIAP2/PTPRD/ERC1/NLGN1/NTRK3/NECTIN3/APP/PIK3R1/ACTB/RDX/MAPK1/PTPN11/TUBB2A/KIRREL3/MAPK8/CADM2/ARF6/CD2AP/VAV2/IL1RAP/EPB41L1/PRKCA/MAGI2/NRCAM/WASL/PLXNA3/CASK/PAK2/SRGAP1/MPDZ/PARD6B/TRAF6/CDH2/SLIT3/GRIP1/CXADR/PALS2/MTSS2/CLMP/PVR/AKT2/ACTR3/PLXNA1/NCAM2/PTPRS/NTN1/NLGN4X/ACTR2/PRKCI/ABL1/PIK3R3/PPFIA4/ACTR3C/PARD3/NECTIN2/KCNQ3/LRFN4/MAP2K1/CADM4/MAPK10/IL1RAPL1/MYL9/PPFIA3/PIK3CB/CADM1/ROBO2/RAP1B/CASKIN2/FOXO1/MPP3/ITGB3/ROBO1/NLGN3/PLCG1/ACTG1/CADM3/SORBS1/RHOA	3.79182748590014
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	96/2748	238/9376	1.37624307364867	RASAL2/RRAS/MET/EFNA5/IGF1R/AFDN/TIAM1/IGF2/GAB1/PLAAT2/PLA2G4A/PLD1/ABL2/GAB2/RALGAPA1/RALB/VEGFA/EGFR/GNB1/SHOC2/PIK3CA/SOS1/BCL2L1/RALGDS/RALGAPB/RASGRF1/SOS2/RASA2/RAP1A/RAB5B/NF1/RASSF5/STK4/EPHA2/PDGFD/PIK3R1/MAPK1/GNB5/PTPN11/MAPK8/SHC3/PDGFB/ETS2/INSR/ARF6/NGF/PLA2G12A/PRKCA/RAB5A/VEGFB/RRAS2/RIN1/RALGAPA2/PAK2/EXOC2/FGFR2/NRAS/RELA/RALBP1/RALA/AKT2/RAF1/ETS1/KSR1/RASGRF2/CALM2/EFNA3/PLA2G6/SHC1/IKBKB/ABL1/PIK3R3/FGFR3/BRAP/FGF18/GNGT1/CHUK/EGF/TBK1/MAP2K1/PRKACB/MAPK10/GNB2/PIK3CB/BDNF/RAP1B/NTF3/ELK1/PLCE1/CALM1/PDGFRA/RASGRP1/PLCG1/KITLG/FGF7/RHOA	3.7855951612254
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	50/2748	109/9376	1.56510823551407	SLC27A6/IRS2/PPP1CB/PTPRF/CREB3L2/OGA/SLC2A1/PYGL/PIK3CA/GSK3B/RPS6KA2/TNFRSF1A/OGT/PIK3R1/PYGB/PTPN11/MAPK8/INSR/RPS6KA3/PPARA/PRKAG2/MTOR/CPT1A/GYS1/PRKAA1/STAT3/RPS6KA6/CREB5/PRKAB2/RELA/SLC27A1/CREB1/AKT2/CREB3/GFPT1/PTPA/SREBF1/IKBKB/ACACB/PIK3R3/SLC27A4/PTEN/CRTC2/PPP1R3E/MAPK10/SOCS3/PIK3CB/PRKCE/PRKAA2/FOXO1	3.82100896320852
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	64/2748	148/9376	1.47543176364137	WNT5A/CDK6/WNT2/IGF1R/NCOA1/DVL1/ERBB2/EGFR/APC/FZD6/PIK3CA/SOS1/CCND1/FOS/WNT11/SOS2/GADD45A/WNT2B/GSK3B/WNT7A/FZD1/NOTCH2/PIK3R1/MAPK1/ESR2/BRAF/SHC3/POLK/AXIN1/CDKN1A/CSNK1A1/MTOR/DDB2/JAG1/GADD45B/WNT10A/NRAS/AKT2/WNT9A/RAF1/SP1/ARAF/FZD7/SHC1/TCF7L1/PIK3R3/FGF18/NCOA3/WNT6/LRP5/EGF/NFKB2/PTEN/BRCA1/MAP2K1/NOTCH3/BRCA2/TCF7/PIK3CB/NOTCH1/HES1/FZD8/WNT5B/FGF7	3.7537730406184
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	38/2748	78/9376	1.66222520807674	CAV2/MET/ITGB1/GAB1/FN1/PTK2/VCL/CDH1/CLTB/SRC/PIK3CA/DOCK1/PXN/CTNNA1/PIK3R1/ACTB/SHC3/CD2AP/SEPTIN8/DNM2/ELMO3/WASL/CLTC/SEPTIN9/CAV1/SEPTIN1/ELMO2/ACTR3/SHC1/ACTR2/PIK3R3/ACTR3C/SEPTIN2/PIK3CB/DNM3/CTNNA3/ACTG1/RHOA	3.78147289163681
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	57/2748	130/9376	1.49600268726906	COL3A1/EDN1/COL4A5/TGFBR2/MAP2K4/CREB3L2/COL1A2/ADCY7/SRC/VEGFA/COL4A6/EGFR/GNB1/PIK3CA/SOS1/FOS/SOS2/SMAD2/ADCY9/ATF4/TGFBR1/PIK3R1/MAPK1/GNB5/GNA15/MAPK8/SHC3/PRKCA/VEGFB/MAP2K7/COL1A1/CREB5/PLCB4/NRAS/RELA/CREB1/AKT2/EDNRB/RAF1/CREB3/ATF2/SHC1/ADCY6/PIK3R3/GNGT1/PLCB1/COL4A4/MAP2K1/PRKACB/MAPK10/ADCY3/GNB2/PLCB3/PIK3CB/COL4A2/MMP2/ACTA2	3.66675179757134
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	42/2748	90/9376	1.59223677826298	PPP3CA/HIF1A/PPP3CC/EGFR/PIK3CA/FOS/NFATC2/JAK1/PIK3R1/JAK2/MAPK1/PTPN11/PPP3CB/MTOR/MAP3K3/STAT3/STAT1/NFATC3/TRAF6/NRAS/RELA/AKT2/RAF1/NFATC1/BATF/CSNK2A1/IKBKB/PIK3R3/IFNGR1/CHUK/EGF/TIRAP/BATF3/PTEN/MAP2K1/PIK3CB/ALK/MYD88/TICAM1/RASGRP1/PLCG1/CD274	3.63500524140788
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	59/2748	137/9376	1.46937387775051	CAPN2/TUBA4A/ITPR3/SPTAN1/TUBA1A/NOL3/PARP4/PIK3CA/BCL2L1/FOS/GADD45A/EIF2AK3/TNFRSF1A/CTSZ/ATF4/LMNA/XIAP/PIK3R1/ACTB/MAPK1/MAPK8/NGF/CTSF/CTSD/CFLAR/MAP3K14/ATM/BIRC2/MCL1/RIPK1/GADD45B/NRAS/RELA/AKT2/RAF1/MAP3K5/CTSV/ERN1/ITPR1/IKBKB/ITPR2/PIK3R3/TRADD/BIRC3/HRK/CHUK/CTSW/CTSK/GZMB/MAP2K1/CTSL/MAPK10/PTPN13/PIK3CB/DDIT3/PARP3/APAF1/ACTG1/BCL2L11	3.56344014626464
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	81/2748	200/9376	1.38183406113537	MYH14/NCKAP1/MYO6/MYO1E/TUBA4A/MYO5B/EZR/ITGB1/TMED10/ARHGEF12/MYO1D/TUBA1A/FYN/BAIAP2L1/SRC/TAB3/ROCK1/TUBB6/SEC24B/ABI1/FOS/CLDN4/MYH9/TAB2/BAIAP2/MYO1C/TNFRSF1A/SEC24D/ROCK2/IL1R1/ACTB/MAPK1/PTPN11/TUBB2A/MAPK8/ARHGEF11/CLDN1/CYTH2/ARF6/GNA13/WIPF2/CLDN9/CYFIP1/CYTH3/WASL/OCLN/IRAK4/PAK2/SEC24A/RIPK1/SEC24C/TRAF6/MYO5A/RELA/ACTR3/MYO1B/CLDN12/WASF3/CYTH1/IKBKB/ACTR2/IRAK1/TMBIM6/CLDN15/ABL1/ACTR3C/ARHGEF1/TRADD/CHUK/TIRAP/ARF1/MYO10/MAPK10/CLDN3/LPAR2/ARHGEF2/CLDN6/MYD88/F2R/ACTG1/RHOA	3.51451753517349
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	48/2748	107/9376	1.53058809125413	GNAQ/PPP3CA/PFKP/CAMK2D/ITPR3/CREB3L2/PPP3CC/SLC2A1/PYGL/SIK1/PHKA1/ATF4/EP300/CREBBP/PPP4R3B/PHKA2/PYGB/SIK2/PPP3CB/PPP4R3A/PHKB/PPARA/PRKAG2/CPT1A/GYS1/PRKAA1/CREB5/PRKAB2/PKM/PLCB4/CREB1/AKT2/CREB3/CALM2/SIRT1/ITPR1/ATF2/ITPR2/ACACB/PLCB1/CRTC2/PRKACB/PLCB3/PFKM/PRKAA2/CALM1/FOXO1/PHKG1	3.5541495551958
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	18/2748	30/9376	2.0471615720524	PIGT/PIGN/PIGK/PGAP4/PGAP1/PGAP3/GPAA1/PIGP/MPPE1/PIGS/PIGG/PIGQ/PIGA/PIGM/PIGL/PIGX/PIGO/PIGB	3.69882843772621
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	45/2748	99/9376	1.55087997882758	IGF1R/PTK2/ERBB2/ADCY7/SRC/EGFR/PIK3CA/SOS1/CCND1/FOS/SOS2/ADCY9/NCOR1/NOTCH2/PIK3R1/MAPK1/ESR2/BRAF/MAPK8/SHC3/CDKN1A/BIK/MTOR/CARM1/JAG1/MED1/NRAS/AKT2/RAF1/SP1/ARAF/SHC1/ADCY6/GPER1/PIK3R3/NCOA3/MAP2K1/PRKACB/MAPK10/NOTCH3/ADCY3/PIK3CB/NOTCH1/MDM2/MMP2	3.54791788882256
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	34/2748	70/9376	1.65722603451861	MET/HIF1A/GAB1/EGLN3/SLC2A1/VEGFA/PIK3CA/SOS1/SOS2/RAP1A/EP300/CREBBP/PIK3R1/MAPK1/PTPN11/BRAF/PDGFB/CDKN1A/TFE3/PAK2/NRAS/ARNT/AKT2/RAF1/ETS1/CUL2/RAPGEF1/ARAF/PIK3R3/EGLN1/MAP2K1/FLCN/PIK3CB/RAP1B	3.55373473438028
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	35/2748	73/9376	1.63585970369484	CDK6/MET/KIF5B/ERBB2/EGFR/FOXO3/PIK3CA/SOS1/CCND1/SOS2/GADD45A/RASSF5/STK4/PIK3R1/FHIT/MAPK1/BRAF/POLK/CDKN1A/PRKCA/DDB2/STAT3/GADD45B/STAT5B/NRAS/AKT2/RAF1/RXRA/ARAF/PIK3R3/EGF/MAP2K1/PIK3CB/ALK/PLCG1	3.51167224765182
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	60/2748	142/9376	1.44166307891014	CAV2/EDN1/ITGAV/SDC4/ACVR2A/THBD/PTK2/BMPR2/GSTO2/SDC1/GPC1/BMPR1A/MAP2K4/SRC/VEGFA/MEF2A/PIK3CA/FOS/HSP90B1/TNFRSF1A/DUSP1/IL1R1/MGST1/PIK3R1/ACTB/MAPK8/PDGFB/NQO1/PRKAA1/MAP2K7/BMPR1B/MAP2K5/CAV1/IL1R2/ACVR2B/RELA/AKT2/MAP3K5/CALM2/MGST2/IKBKB/KEAP1/PIK3R3/CHUK/CTSL/MAPK10/MAPK7/PIK3CB/PRKAA2/ARHGEF2/CALM1/SDC2/IL1A/CDH5/ITGB3/GSTM2/ACTG1/RHOA/MMP2/PLAT	3.41462554725907
Human Diseases	Cancer: specific types	hsa05214	Glioma	36/2748	76/9376	1.61618018846242	CDK6/CAMK1D/CAMK2D/IGF1R/EGFR/PIK3CA/SOS1/CCND1/SOS2/GADD45A/PIK3R1/MAPK1/BRAF/SHC3/PDGFB/POLK/CDKN1A/PRKCA/MTOR/DDB2/GADD45B/NRAS/AKT2/RAF1/CALM2/ARAF/SHC1/PIK3R3/EGF/PTEN/MAP2K1/PIK3CB/CALM1/PDGFRA/MDM2/PLCG1	3.47276827230284
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	31/2748	63/9376	1.67888911993715	KMT2C/ASH1L/KMT2E/KMT2A/SETD2/EHMT1/SETD7/KMT5B/PLOD1/NSD1/CAMKMT/NSD3/COLGALT1/EZH1/PLOD2/PHYKPL/PLOD3/KMT2B/SMYD3/PRDM2/KMT2D/DLST/AASS/DOT1L/BBOX1/SETDB1/SETD1B/NSD2/SETDB2/SETD1A/TMLHE	3.48118476629901
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	34/2748	71/9376	1.63388482276483	TH/CCND2/SOCS6/SRC/FOXO3/PIK3CA/SOS1/CCND1/FOS/SOS2/SOCS5/GSK3B/PRLR/PIK3R1/JAK2/MAPK1/ESR2/MAPK8/SHC3/SOCS4/STAT3/STAT1/STAT5B/NRAS/RELA/AKT2/RAF1/SHC1/PIK3R3/PRL/MAP2K1/MAPK10/SOCS3/PIK3CB	3.45210575352483
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	59/2748	140/9376	1.43788729465585	GNAQ/RRAS/CCN2/MYLK/ITPR3/CDH1/ADCY7/GNB1/MEF2A/CCND1/MAP1LC3A/SMAD2/ADCY9/TGFBR1/MAPK1/GNB5/GNA13/PIK3C3/SMAD3/PRKAG2/MTOR/NRF1/MEF2D/PRKAA1/RRAS2/PIK3R4/JAG1/APELA/BECN1/SERPINE1/SLC9A1/PRKAB2/PLCB4/NRAS/AKT2/RAF1/HDAC4/HDAC5/CALM2/ITPR1/SMAD4/ADCY6/ITPR2/RYR3/GNGT1/PLCB1/MAP2K1/PRKACB/NOTCH3/ADCY3/GNB2/SPHK2/PLCB3/PRKCE/PRKAA2/CALM1/ADCY10/ACTA2/PLAT	3.36114425817933
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	62/2748	150/9376	1.41026686074721	WNT5A/JUP/WNT2/MET/GAB1/TGFBR2/CDH1/DVL1/ERBB2/CDKN2B/EGFR/APC/FZD6/PIK3CA/SOS1/CCND1/WNT11/SOS2/GADD45A/WNT2B/GSK3B/SMAD2/CTNNA1/WNT7A/FZD1/TGFBR1/PIK3R1/MAPK1/BRAF/SHC3/POLK/AXIN1/CDKN1A/SMAD3/CSNK1A1/MTOR/DDB2/FGFR2/GADD45B/WNT10A/NRAS/AKT2/WNT9A/RAF1/RXRA/ARAF/FZD7/SHC1/SMAD4/TCF7L1/PIK3R3/FGF18/WNT6/LRP5/EGF/MAP2K1/TCF7/PIK3CB/CTNNA3/FZD8/WNT5B/FGF7	3.26143025164225
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	38/2748	83/9376	1.56209115939741	L3MBTL4/KDM2A/SCMH1/MBD5/PHC3/LCOR/EP300/CREBBP/OGT/YAF2/RYBP/ASXL2/MGA/AUTS2/FOXK2/EZH1/BCOR/USP16/USP7/BMI1/PCGF3/CBX6/BAP1/FBRS/HCFC1/PHC1/FBRSL1/ASXL1/KDM2B/L3MBTL1/JARID2/SCML1/CBX7/UBE2D3/PHF19/L3MBTL3/YY2/AEBP2	3.31184943826284
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	25/2748	49/9376	1.74078364970442	GALNT6/C1GALT1/GALNT3/B4GALT2/FUT11/GALNTL6/GALNT1/OGT/GALNT5/GXYLT1/GALNT13/RFNG/COLGALT1/GALNT2/POFUT2/PLOD3/GALNT7/POFUT1/POMT2/B4GALT1/B3GLCT/GALNT10/GXYLT2/GALNT18/XXYLT1	3.34750467612204
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	46/2748	106/9376	1.48065145148444	IGF1R/ERBB2/CREB3L2/EGFR/PIK3CA/SOS1/CCND1/SOS2/GSK3B/HSP90B1/ATF4/EP300/CREBBP/PDGFD/PIK3R1/MAPK1/BRAF/PDGFB/FOLR3/CDKN1A/MTOR/FGFR2/IL1R2/CREB5/NRAS/RELA/CREB1/AKT2/RAF1/CREB3/ARAF/IKBKB/TCF7L1/PIK3R3/CHUK/EGF/PTEN/MAP2K1/PLAU/SPINT1/TCF7/PIK3CB/FOXO1/PDGFRA/MDM2/PLAT	3.20439522735784
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	40/2748	90/9376	1.51641597929808	IGF1R/RB1CC1/IRS2/ULK1/SESN3/CREB3L2/ADIPOR1/ADCY7/FOXO3/PIK3CA/RPTOR/EHMT1/ADCY9/ATF4/TSC2/PIK3R1/INSR/APPL1/ATG13/PRKAG2/MTOR/PRKAA1/CREB5/PRKAB2/NRAS/RELA/EIF4EBP1/CREB1/AKT2/CREB3/SIRT1/ATF2/ADCY6/TSC1/PIK3R3/PRKACB/ADCY3/PIK3CB/PRKAA2/FOXO1	3.16963562614435
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	63/2748	156/9376	1.37789721195835	CDK6/YWHAZ/PIAS1/EGFR/PIK3CA/SOS1/LDLR/CCND1/CLDN4/SOS2/IFNAR1/JAK1/GSK3B/PPP2R2A/CD81/TNFRSF1A/PIK3R1/MAPK1/BRAF/CLDN1/CLDN9/CDKN1A/PPARA/YWHAQ/OCLN/CFLAR/PPP2R2B/STAT3/PPP2CB/TRAF3/PPP2R2D/STAT1/RIPK1/TRAF6/MAVS/NRAS/RELA/PPP2R1A/AKT2/RAF1/CLDN12/RXRA/ARAF/IKBKB/CLDN15/STAT2/PIK3R3/YWHAG/TRADD/CHUK/EGF/TBK1/MAP2K1/SOCS3/RNASEL/EIF2AK2/PIK3CB/PPP2R1B/CLDN3/TYK2/CLDN6/TICAM1/APAF1	3.06459634279267
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	50/2748	119/9376	1.4335865350507	EDN1/CYLD/MAP2K4/CREB3L2/PTGS2/TAB3/PIK3CA/TNFAIP3/FOS/TAB2/RPS6KA5/TNFRSF1A/ATF4/XIAP/PIK3R1/MAPK1/RHBDF1/MAPK8/JUNB/DNM1L/MAP2K7/CFLAR/MAP3K14/JAG1/ADAM17/TRAF3/BIRC2/RIPK1/CREB5/RELA/ITCH/NOD2/BAG4/CREB1/AKT2/CREB3/RPS6KA4/MAP3K5/ATF2/IKBKB/PIK3R3/TRADD/BIRC3/CHUK/MAP2K1/MAPK10/IL15/SOCS3/PIK3CB/FRMD8	3.06490408619515
NA	NA	hsa03272	Virion - Hepatitis viruses	24/2748	48/9376	1.70596797671033	CD9/EGFR/LDLR/PDCD6IP/HSPG2/CLDN4/LAMP1/TGOLN2/CD81/EPCAM/CLDN1/CLDN9/OCLN/LAMP2/VPS4B/IST1/CLDN12/CHMP1B/CLDN15/SLC10A1/CD63/CHMP7/CLDN3/CLDN6	3.15728730990781
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	62/2748	154/9376	1.37363655267585	GNAQ/PPP3CA/CAMK1D/CAMK2D/MYLK/ITPR3/PLA2G4A/GUCY1A1/PPP1CB/PTGS2/ADCY7/PPP1R12B/PPP3CC/SRC/EGFR/ROCK1/CCND1/FOS/NFATC2/ADCY9/ROCK2/PPP1R12A/ACTB/MAPK1/PPP3CB/CDKN1A/PRKCA/PRKAG2/CACNA2D3/PRKAA1/RCAN1/MAP2K5/NFATC3/CACNG4/PRKAB2/PPP1R12C/PLCB4/NRAS/RAF1/KCNJ2/GUCY1B1/CALM2/NFATC1/ITPR1/ADCY6/ITPR2/RYR3/PLCB1/MAP2K1/PRKACB/ADCY3/MAPK7/MYL9/PLCB3/ELK1/CACNB3/PRKAA2/CALM1/OXTR/ACTG1/CACNB2/RHOA	3.01023159991891
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	55/2748	134/9376	1.40042147341893	MYH14/GNAQ/EDN1/MYLK/KCNMB4/ITPR3/KCNMA1/AVPR1A/PLA2G4A/GUCY1A1/ARHGEF12/PPP1CB/ADCY7/PPP1R12B/ROCK1/MYH9/PRKCH/ADCY9/ADRA1B/ROCK2/PPP1R12A/MAPK1/GNA11/BRAF/PRKG1/ARHGEF11/GNA13/EDN2/PLA2G12A/PRKCA/CALD1/RAMP1/PPP1R12C/PLCB4/RAF1/GUCY1B1/CALM2/ITPR1/ARAF/PLA2G6/ADCY6/ITPR2/ARHGEF1/PLCB1/MAP2K1/PRKACB/KCNMB3/ADCY3/MYL9/PLCB3/PRKCE/CALM1/ADORA2B/RHOA/ACTA2	3.00600382569377
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	29/2748	62/9376	1.59590552659999	KAT2B/ATXN1/DVL1/MAML2/CTBP2/TLE4/SPEN/TLE1/EP300/CREBBP/NCOR2/NOTCH2/PSEN1/RFNG/NUMB/MAML3/APH1B/NUMBL/NCSTN/JAG1/ADAM17/ITCH/CTBP1/ATXN1L/CIR1/NOTCH3/DTX3/NOTCH1/HES1	3.03115324697717
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	43/2748	101/9376	1.45260639601078	GNAQ/WNT5A/EDN1/WNT2/CAMK2D/DVL1/CREB3L2/ADCY7/FZD6/WNT11/WNT2B/GSK3B/ADCY9/WNT7A/EP300/CREBBP/FZD1/MAPK1/PRKCA/WNT10A/PLCB4/NRAS/CREB1/WNT9A/EDNRB/RAF1/CREB3/CALM2/FZD7/ADCY6/TCF7L1/PLCB1/WNT6/MAP2K1/PRKACB/ADCY3/TCF7/PLCB3/CALM1/FZD8/WNT5B/KITLG/MC1R	2.94460582700319
Cellular Processes	Cell motility	hsa04814	Motor proteins	75/2748	194/9376	1.31904740467294	MYH14/KIF13A/MYO6/MYO1E/DYNC1H1/TUBA4A/MYO5B/KIF1C/KLC3/KIF5B/MYO9A/TPM1/MYO1D/TUBA1A/MYO15B/MYO18A/KLC1/KIFC2/KIFAP3/TUBB6/DYNLT3/TNNT1/MYH9/KIF1B/DNAH5/MYO1C/HOOK3/MYO9B/KIF3A/KIFC3/DCTN1/DYNC1LI2/ACTB/TUBB2A/MYO3B/DYNC2H1/KIF3B/DYNC1I2/MYO16/KIF9/DNAI4/KIF16B/DNAH7/ACTR10/BICDL1/DNAH11/DNAH14/MYO5A/CAPZA2/KIF21A/MYO1B/DNAL1/TNNT2/KIF27/TUBE1/ACTR1B/DNALI1/KLC4/TUBG2/MYO10/DYNLT1/TNNC2/MYL9/TUBD1/KLC2/MYL5/DNAH1/TPM2/KIF3C/KIF13B/ACTG1/KIF7/STARD9/DNAH12/ACTA2	2.89128024880143
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	32/2748	71/9376	1.53777395083749	PFKP/MET/HIF1A/SLC16A3/SLC1A5/ERBB2/SLC2A1/EGFR/PIK3CA/PDK1/GLS/NTRK3/HK2/PIK3R1/MAPK1/MTOR/SIRT3/FGFR2/PKM/NRAS/HK1/AKT2/RAF1/SLC7A5/PIK3R3/FGFR3/SIRT6/PTEN/MAP2K1/PIK3CB/PFKM/PDGFRA	2.92869064396358
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	56/2748	139/9376	1.37459290209754	KRT24/KRT17/KRT14/GNAQ/ITPR3/KRT16/KRT19/NCOA1/CREB3L2/ADCY7/SRC/EGFR/PIK3CA/SOS1/NCOA2/FKBP5/KRT13/FOS/SOS2/ADCY9/KRT15/HSP90B1/ATF4/PIK3R1/MAPK1/ESR2/SHC3/CTSD/EBAG9/CREB5/KRT27/PLCB4/NRAS/CREB1/AKT2/RAF1/CREB3/SP1/CALM2/ITPR1/ATF2/SHC1/ADCY6/ITPR2/GPER1/PIK3R3/NCOA3/PLCB1/MAP2K1/PRKACB/ADCY3/PLCB3/PIK3CB/RARA/CALM1/MMP2	2.86486541639633
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	29/2748	63/9376	1.57057369284444	WNT5A/WNT2/DVL1/APC/FZD6/WNT11/GADD45A/WNT2B/GSK3B/WNT7A/FZD1/POLK/AXIN1/CDKN1A/BMP2/DDB2/GADD45B/WNT10A/WNT9A/FZD7/TCF7L1/PTCH2/PTCH1/WNT6/SUFU/TCF7/FZD8/WNT5B/KIF7	2.92576856698615
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	26/2748	55/9376	1.61291517798068	CERS6/SGMS2/ASAH1/KDSR/SGMS1/SPTLC3/PSAP/SMPD1/PLPP2/ARSA/PLPP1/CERK/SPTLC1/SGPP2/SPTLC2/CERS5/GALC/PLPP3/B4GALT5/SMPD4/SAMD8/SGPL1/ACER2/UGCG/SPHK2/B4GALT6	2.93530489932093
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	17/2748	32/9376	1.81259097525473	ATG9B/RPTOR/ATG7/ULK2/PIK3C3/ATG13/MTOR/ATG10/ATG2B/PIK3R4/PPP2CB/BECN1/ATG4B/WIPI1/ATG4D/ATG12/ATG2A	2.9647175311792
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	61/2748	155/9376	1.3427618913462	GNAQ/WNT5A/CDK6/WNT2/CAMK2D/ITPR3/DVL1/CREB3L2/ADCY7/CDKN2B/EGFR/APC/FZD6/LDLR/CCND1/KMT2A/WNT11/PBX1/WNT2B/GSK3B/RAP1A/ADCY9/ATF4/NCEH1/WNT7A/FZD1/PDE8A/MAPK1/GNA11/AHR/BRAF/AXIN1/CDKN1A/USP8/CREB5/WNT10A/PLCB4/ARNT/KMT2D/CREB1/WNT9A/CREB3/SP1/ITPR1/ATF2/FZD7/ADCY6/ITPR2/TCF7L1/PLCB1/WNT6/ARMC5/MAP2K1/PRKACB/ADCY3/RBBP5/TCF7/PLCB3/RAP1B/FZD8/WNT5B	2.77058909925924
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	37/2748	86/9376	1.46792593344843	ITGB6/DSG2/ITGB4/JUP/DSC2/DSP/ITGA2/ITGAV/ITGA6/ITGB1/GJA1/DAG1/ATP2A2/CTNNA1/LMNA/PKP2/ACTB/ITGB5/SGCE/ITGB8/CACNA2D3/ITGA3/CDH2/CACNG4/TCF7L1/DMD/SGCZ/SNTB2/TCF7/LAMA2/ITGB7/CACNB3/CTNNA3/ITGB3/ACTG1/CACNB2/ITGA1	2.80686313460264
Organismal Systems	Immune system	hsa04611	Platelet activation	51/2748	126/9376	1.38102169543218	COL3A1/GNAQ/MYLK/ITGA2/ITPR3/ITGB1/PLA2G4A/GUCY1A1/ARHGEF12/PPP1CB/STIM1/FYN/COL1A2/ADCY7/SRC/ARHGAP35/PIK3CA/ROCK1/RAP1A/ADCY9/ROCK2/PPP1R12A/PIK3R1/ACTB/MAPK1/PRKG1/GNA13/SNAP23/TLN2/COL1A1/PLCB4/AKT2/GUCY1B1/ITPR1/ADCY6/ITPR2/PRKCI/PIK3R3/ARHGEF1/PLCB1/PRKACB/ADCY3/PLCB3/PIK3CB/RAP1B/VWF/ITGB3/RASGRP1/F2R/ACTG1/RHOA	2.77247005359132
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	84/2748	224/9376	1.27947598253275	PPP3CA/TSPO/KAT2B/CD40/TGFBR2/CCND2/MAP2K4/CREB3L2/DLG1/ADCY7/PPP3CC/CDKN2B/SLC2A1/PIK3CA/BCL2L1/CCND1/FOS/NFATC2/JAK1/SMAD2/ADCY9/TNFRSF1A/ATF4/ELK4/EP300/CREBBP/IL1R1/LTBR/TGFBR1/XIAP/PIK3R1/MAPK1/MAPK8/ETS2/PPP3CB/MAP3K1/TRRAP/ATR/CDKN1A/SMAD3/CDC27/XPO1/MAP3K3/TLN2/MAP3K14/ATM/CDC16/IL1R2/NFATC3/STAT5B/CREB5/ZFP36/NRAS/ANAPC1/RELA/CREB1/AKT2/ETS1/CREB3/NFATC1/KAT5/ATF2/FOSL1/SMAD4/IKBKB/ADCY6/VAC14/PIK3R3/TCF3/CHUK/SRF/CRTC3/NFKB2/PTEN/MAP2K1/CRTC2/PRKACB/MAPK10/IL15/ADCY3/PIK3CB/ELK1/MSX1/HLA-C	2.72592088844635
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	30/2748	67/9376	1.52773251645702	GNAQ/PPP3CA/CAMK2D/ITPR3/PPP1CB/PPP3CC/RAP1A/RPS6KA2/ATF4/EP300/CREBBP/MAPK1/BRAF/PPP3CB/RPS6KA3/PRKCA/RPS6KA6/PLCB4/NRAS/RAF1/CALM2/ITPR1/ARAF/ITPR2/PLCB1/MAP2K1/PRKACB/PLCB3/RAP1B/CALM1	2.79127414587708
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	39/2748	93/9376	1.43081185143447	GNAQ/CAMK2D/ITPR3/PLA2G4A/PLD1/MAP3K2/MAP2K4/ADCY7/SRC/EGFR/SOS1/SOS2/ADCY9/ATF4/MAPK1/GNA11/MAPK8/MAP3K1/PRKCA/MAP3K3/MAP2K7/PLCB4/NRAS/RAF1/CALM2/ITPR1/ADCY6/ITPR2/PTK2B/PLCB1/MAP2K1/PRKACB/MAPK10/ADCY3/MAPK7/PLCB3/ELK1/CALM1/MMP2	2.68836166313947
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	64/2748	166/9376	1.31544518686098	ATP2B4/GNAQ/PPP3CA/MYLK/KCNMB4/ITPR3/KCNMA1/IRS2/GUCY1A1/PPP1CB/CREB3L2/ADCY7/PPP3CC/MEF2A/ROCK1/NFATC2/ATP1B1/ATP2A2/ADCY9/ATP1A1/ATF4/ADRA1B/ROCK2/PPP1R12A/ATP1A4/ATP2B1/MAPK1/CNGA1/GNA11/PRKG1/PPP3CB/INSR/GTF2I/GNA13/MEF2D/PDE5A/NFATC3/CREB5/PLCB4/CREB1/AKT2/EDNRB/RAF1/CREB3/GUCY1B1/CALM2/NFATC1/ITPR1/ATF2/ADCY6/ITPR2/PLCB1/BDKRB2/SRF/MAP2K1/ADRB2/KCNMB3/ADCY3/PDE3A/MYL9/PLCB3/PRKCE/CALM1/RHOA	2.64028547578682
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	20/2748	41/9376	1.66435900166862	THBS1/DAPK1/CDH1/ERBB2/SRC/VEGFA/EGFR/CCND1/RPS6KA5/MAPK1/BRAF/CDKN1A/NRAS/RAF1/ARAF/FGFR3/EGF/MAP2K1/MDM2/MMP2	2.74498732573587
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	43/2748	105/9376	1.39726900949608	PPP3CA/RRAS/ITPR3/ARHGEF12/CYLD/PTGS2/PPP3CC/SRC/PIK3CA/NFATC2/PLK3/PIK3R1/MAPK1/PTPN11/MAPK8/PPP3CB/CBLB/MALT1/RRAS2/MAP3K14/STAT1/NFATC3/NRAS/RELA/AKT2/RAF1/KSR1/CALM2/NFATC1/ITPR1/IKBKB/ITPR2/MAPKAPK2/STAT2/PIK3R3/CLEC7A/CHUK/NFKB2/MAPK10/PIK3CB/CALM1/MDM2/RHOA	2.63583851164494
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	84/2748	227/9376	1.26256660831426	AKAP13/GNAQ/PPP3CA/CDK6/ITPR3/ITGAV/PTK2/ARHGEF12/CREB3L2/PTGS2/ADCY7/PPP3CC/SRC/VEGFA/EGFR/GNB1/PIK3CA/SOS1/ROCK1/CCND1/NFATC2/SOS2/JAK1/PXN/GSK3B/ADCY9/TNFRSF1A/ATF4/ROCK2/IL1R1/TSC2/PIK3R1/MAPK1/GNB5/GNA11/ARHGEF11/PPP3CB/GNA13/CDKN1A/PRKCA/MTOR/STAT3/RIPK1/NFATC3/CREB5/PLCB4/NRAS/RELA/EIF4EBP1/CREB1/AKT2/RAF1/CREB3/SP1/CALM2/NFATC1/ITPR1/ATF2/IKBKB/ADCY6/ITPR2/TSC1/PIK3R3/PTK2B/ARHGEF1/GNGT1/TRADD/PLCB1/CHUK/TBK1/MAP2K1/PRKACB/ADCY3/GNB2/PLCB3/PIK3CB/ELK1/CALM1/CCR3/PDGFRA/ITGB3/MDM2/RHOA/HLA-C	2.57850727790338
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/2748	19/9376	1.97533134145407	HGSNAT/GNS/HYAL2/IDS/SGSH/GALNS/HYAL1/IDUA/HPSE/HYAL4/HYAL3	2.74008110803726
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	37/2748	89/9376	1.41844528400635	GNAQ/TUBA4A/ITPR3/GJA1/GUCY1A1/TUBA1A/MAP3K2/ADCY7/SRC/EGFR/SOS1/TUBB6/SOS2/ADCY9/PDGFD/MAPK1/GNA11/TUBB2A/PDGFB/PRKG1/PRKCA/MAP2K5/PLCB4/NRAS/RAF1/GUCY1B1/ITPR1/ADCY6/ITPR2/PLCB1/EGF/MAP2K1/PRKACB/ADCY3/MAPK7/PLCB3/PDGFRA	2.55386955387281
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	15/2748	29/9376	1.76479445866586	TEAD1/WWTR1/YAP1/STK3/LATS2/LATS1/SAV1/WWC1/NF2/CSNK1E/MOB1A/WTIP/FAT4/MOB1B/TPTEP2-CSNK1E	2.65589170610655
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	73/2748	196/9376	1.27077206428423	PPP3CA/CDK6/ITPR3/HIF1A/MAP2K4/PTGS2/PPP3CC/SRC/VEGFA/GNB1/PIK3CA/CCND1/FOS/NFATC2/IFNAR1/JAK1/MAP1LC3A/GSK3B/TNFRSF1A/EP300/CREBBP/PIK3R1/JAK2/MAPK1/GNB5/MAPK8/PDGFB/PPP3CB/PIK3C3/CDKN1A/MTOR/UBC/MAP2K7/ATG14/RCAN1/STAT3/TRAF3/BECN1/STAT1/NFATC3/ZFP36/NRAS/RELA/CREB1/AKT2/RAF1/CALM2/NFATC1/ITPR1/IL6ST/IKBKB/ITPR2/TCF7L1/MAPKAPK2/STAT2/PIK3R3/IFNGR1/GNGT1/TRADD/CHUK/TBK1/MAP2K1/MAPK10/GNB2/EIF2AK2/TCF7/PIK3CB/TYK2/CALM1/CCR3/TICAM1/PLCG1/HLA-C	2.46668278851466
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	60/2748	157/9376	1.30392456818624	THBS1/GAS6/CAMK2D/ITGAV/ADAM10/HIF1A/MFGE8/PTK2/ANO6/ATP11B/TMEM30A/PTGS2/SLC2A1/ADAM9/DUSP7/DOCK1/NFATC2/P2RY2/PBX1/GULP1/ATP2A2/ODC1/LRP1/RAB5B/VPS41/ATP11A/PANX1/ITGB5/JAK2/MAPK1/PTPN11/DUSP4/VPS8/RAB5A/CPT1A/ADAM17/NFATC3/TMEM30B/ARNT/VPS39/CREB1/MERTK/ATP11C/RXRA/NFATC1/SIRT1/PLA2G6/XKR6/RAB7A/MAPKAPK2/AXL/ABCA1/ANO4/MAP2K1/SGK1/ANO9/SPHK2/VPS18/VPS16/ITGB3	2.47272875699876
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	10/2748	17/9376	2.00702114907098	MYH14/PCDH7/PCDH9/PCDH1/LAMP1/DAG1/MYH9/LAMP2/PCDH11X/PCDH11Y	2.67578417611954
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	48/2748	122/9376	1.34240103085403	PPP3CA/PPP2R3A/FYN/DLG1/PPP3CC/PIK3CA/SOS1/FOS/NFATC2/SOS2/GSK3B/PPP2R2A/PPP2R5E/PPP2R5C/PIK3R1/MAPK1/PTPN11/MAPK8/PPP3CB/CBLB/VAV2/PPP2R5B/MALT1/MAP2K7/PAK2/PPP2R2B/PPP2CB/MAP3K14/PPP2R2D/NFATC3/PPP2R5A/NRAS/RELA/PPP2R1A/AKT2/RAF1/NFATC1/IKBKB/PIK3R3/PPP2R5D/CHUK/MAP2K1/MAPK10/PIK3CB/PPP2R1B/RASGRP1/PLCG1/RHOA	2.45105458892971
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	14/2748	27/9376	1.76915197584775	HACD2/HACD4/SCD5/ACOX1/ELOVL6/ELOVL1/ELOVL7/HSD17B12/ELOVL5/SCD/TECR/HACD1/HACD3/ACOT7	2.57699879059257
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	29/2748	68/9376	1.45509033307646	JUP/PIK3CA/SOS1/CCND1/SOS2/RUNX1/PER2/PIK3R1/MAPK1/BRAF/MTOR/STAT3/STAT5B/NRAS/RELA/EIF4EBP1/AKT2/RAF1/ARAF/IKBKB/TCF7L1/PIK3R3/CHUK/MAP2K1/ZBTB16/TCF7/PIM1/PIK3CB/RARA	2.42508313843295
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	63/2748	168/9376	1.27947598253275	PIAS1/CLCF1/CCND2/SOCS6/EGFR/PIK3CA/SOS1/BCL2L1/CCND1/STAM/SOS2/IFNAR1/SOCS5/JAK1/LEPR/PIAS3/EP300/CREBBP/PRLR/PIK3R1/JAK2/PTPN11/PDGFB/IL22RA1/CDKN1A/MTOR/SOCS4/IFNLR1/GHR/OSMR/STAT3/STAT6/STAM2/CSH1/STAT1/MCL1/STAT5B/STAT4/IL20RB/AKT2/RAF1/IL6ST/LIFR/STAT2/PIK3R3/IFNGR1/PRL/CTF1/PIAS2/FHL1/EGF/CSHL1/IL15/SOCS3/PIM1/PIK3CB/IFNL3/IL31RA/IFNL2/TYK2/IL7/PDGFRA/CSH2	2.3535272425423
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	39/2748	98/9376	1.35781124676945	GSN/ASAP2/ASAP1/PLA2G4A/PLD1/GAB2/PIK3CA/PLPP2/DOCK1/MARCKS/PIP5K1A/PIK3R1/MAPK1/PLPP1/ARF6/VAV2/INPPL1/DNM2/PRKCA/SCIN/PIP5K1B/PLPP3/AKT2/RAF1/ACTR3/CFL2/WASF3/PLA2G6/ACTR2/PIP5K1C/LIMK1/PIK3R3/ACTR3C/MAP2K1/MYO10/SPHK2/PIK3CB/PRKCE/PLCG1	2.29267551837325
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	43/2748	110/9376	1.33375678179172	PFKP/EDN1/CAMK2D/IGF1R/HIF1A/TIMP1/ERBB2/EGLN3/SLC2A1/VEGFA/EGFR/PIK3CA/PDK1/EP300/CREBBP/LTBR/HK2/PIK3R1/MAPK1/ALDOC/INSR/CDKN1A/PRKCA/ENO2/MTOR/STAT3/MKNK2/SERPINE1/ARNT/HK1/RELA/EIF4EBP1/AKT2/PGK1/CUL2/PIK3R3/IFNGR1/EGF/EGLN1/MAP2K1/PIK3CB/PFKM/PLCG1	2.26716457135884
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	31/2748	75/9376	1.41026686074721	THBS1/SFN/IGFBP3/CDK6/PERP/SERPINB5/CCND2/SESN3/BCL2L1/CCND1/CCNG2/PPP1R13L/GADD45A/TP53I3/ZMAT3/COP1/TSC2/CD82/ATR/RRM2B/CDKN1A/MDM4/DDB2/ATM/SERPINE1/GADD45B/PTEN/PPM1D/GORAB/MDM2/APAF1	2.2968625162934
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	31/2748	75/9376	1.41026686074721	GNAQ/ITPR3/CREB3L2/ADCY7/ATP1B1/ADCY9/ATP1A1/HSP90B1/ATF4/ATP1A4/DUOX1/PRKCA/TTF1/GPX8/HSPA5/CREB5/PLCB4/PAX8/CREB1/CREB3/ITPR1/ATF2/ADCY6/ITPR2/PLCB1/GPX1/PRKACB/ADCY3/LRP2/PLCB3/TSHR	2.2968625162934
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	17/2748	36/9376	1.61119197800421	B3GNT3/GALNT6/GCNT1/C1GALT1/GALNT3/GALNTL6/GALNT1/GALNT5/GALNT13/ST6GALNAC2/GALNT2/GALNT7/B4GALT5/ST6GALNAC1/ST3GAL1/GALNT10/GALNT18	2.36569204886847
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	45/2748	116/9376	1.3235958439994	EZR/CD99/AFDN/ARHGAP5/ITGB1/PTK2/VCL/F11R/ARHGAP35/PIK3CA/ROCK1/CLDN4/PXN/RAP1A/CTNNA1/RASSF5/ROCK2/PIK3R1/ACTB/PTPN11/CLDN1/VAV2/CLDN9/CD99L2/PRKCA/OCLN/CTNND1/CLDN12/CLDN15/PIK3R3/PTK2B/RAPGEF4/MYL9/PIK3CB/MYL5/CLDN3/RAP1B/CTNNA3/CLDN6/CDH5/THY1/PLCG1/ACTG1/RHOA/MMP2	2.25802730373081
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	41/2748	105/9376	1.33227975324045	CD40/CYLD/PTGS2/TAB3/BCL2L1/TNFAIP3/PPP1R13L/GADD45A/TAB2/BLNK/TNFRSF1A/ERC1/IL1R1/LTBR/XIAP/MALT1/IRAK4/CFLAR/MAP3K14/ATM/TRAF3/BIRC2/RIPK1/GADD45B/TRAF6/RELA/CSNK2A1/IKBKB/IRAK1/TRADD/BIRC3/CHUK/TIRAP/NFKB2/PLAU/TRIM25/MYD88/TICAM1/CARD10/EDA2R/PLCG1	2.20464156351389
Human Diseases	Cancer: specific types	hsa05218	Melanoma	30/2748	73/9376	1.40216546030986	CDK6/MET/IGF1R/CDH1/EGFR/PIK3CA/CCND1/GADD45A/PDGFD/PIK3R1/MAPK1/BRAF/PDGFB/POLK/CDKN1A/DDB2/GADD45B/NRAS/AKT2/RAF1/ARAF/PIK3R3/FGF18/EGF/PTEN/MAP2K1/PIK3CB/PDGFRA/MDM2/FGF7	2.22104542515882
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	11/2748	21/9376	1.78720454702987	CHPF/CHPF2/B3GAT3/CHSY3/CSGALNACT2/DSE/B3GALT6/XYLT2/CHST3/CSGALNACT1/CHSY1	2.32529521522872
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	40/2748	103/9376	1.32502367123133	LAMB3/COL3A1/LAMA3/GNAQ/LAMC1/COL4A5/LAMB2/FN1/PTK2/VCL/COL1A2/LAMA5/COL4A6/PIK3CA/RAB5B/LAMB4/IL1R1/PIK3R1/GNA15/GNA11/LAMC2/PRKCA/RAB5A/COL1A1/LAMB1/IL1R2/PLCB4/RELA/SERPINB10/RAB7A/PIK3R3/PLCB1/COL4A4/HSPB1/GNAL/PRKACB/PLCB3/PIK3CB/LAMA2/COL4A2	2.13563105001574
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/2748	37/9376	1.56764624886896	CDH1/CCND1/CCDC6/GADD45A/TPR/MAPK1/BRAF/POLK/CDKN1A/DDB2/GADD45B/NRAS/PAX8/RXRA/TCF7L1/MAP2K1/TCF7	2.22756917308455
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	50/2748	133/9376	1.28268268925589	GNAQ/PPP3CA/TH/CAMK2D/ITPR3/PPP2R3A/KIF5B/PPP1CB/CREB3L2/CLOCK/PPP3CC/GNB1/FOS/GSK3B/PPP2R2A/ATF4/PPP2R5E/PPP2R5C/GNB5/MAPK8/PPP3CB/PPP2R5B/PRKCA/PPP2R2B/PPP2CB/PPP2R2D/CREB5/PPP2R5A/PLCB4/PPP2R1A/CREB1/AKT2/CREB3/CALM2/MAOA/ITPR1/ATF2/ITPR2/GNGT1/PPP2R5D/PLCB1/GNAL/PRKACB/MAPK10/GNB2/PLCB3/PPP2R1B/GRIA3/CALM1/GRIA4	2.11407947958842
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	25/2748	60/9376	1.42163998059195	PPP3CA/PLA2G4A/PTK2/PTGS2/PPP3CC/SRC/VEGFA/PIK3CA/NFATC2/PXN/PIK3R1/MAPK1/MAPKAPK3/PPP3CB/PRKCA/NRAS/AKT2/RAF1/MAPKAPK2/PIK3R3/HSPB1/MAP2K1/SPHK2/PIK3CB/PLCG1	2.10962577260084
Organismal Systems	Nervous system	hsa04730	Long-term depression	25/2748	60/9376	1.42163998059195	GNAQ/ITPR3/IGF1R/PLA2G4A/GUCY1A1/MAPK1/GNA11/BRAF/PRKG1/GNA13/PRKCA/PPP2CB/PLCB4/NRAS/PPP2R1A/RAF1/GUCY1B1/ITPR1/ARAF/ITPR2/PLCB1/MAP2K1/PLCB3/PPP2R1B/GRIA3	2.10962577260084
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	51/2748	138/9376	1.26093285235112	PPP3CA/CAMK2D/ITPR3/IGF1R/YWHAZ/PPP1CB/SLK/ADCY7/PPP3CC/CPEB4/CPEB2/FBXW11/ADCY9/RPS6KA2/PPP2R5E/BTRC/PPP2R5C/MAPK1/PPP3CB/RPS6KA3/PPP2R5B/SMC1A/YWHAQ/SPDYA/CDC27/PPP2CB/SMC3/CDC16/RPS6KA6/PPP2R5A/ANAPC1/PPP2R1A/SPDYE2/CALM2/ITPR1/ADCY6/ITPR2/CUL1/CPEB3/YWHAG/PPP2R5D/SPDYE1/MAP2K1/PRKACB/ADCY3/SPDYE21/PPP2R1B/SPDYE5/CALM1/SPDYE18/STAG3	1.98830075987677
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	41/2748	108/9376	1.29527198231711	RANBP2/RANBP17/IPO7/THOC2/KPNA4/NUP214/TPR/KPNA6/AHCTF1/XPO6/KPNA3/UPF2/UPF3A/SENP2/XPO7/NUP153/XPO4/KPNA1/NUP205/XPO1/TNPO3/TNPO2/NMD3/IPO9/TNPO1/CASC3/SRRM1/NUP155/XPO5/POM121C/PHAX/KPNA5/IPO8/IPO11/NUP98/IPO13/NUP133/NCBP1/NUP188/GLE1/NUP210L	1.98721042766699
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	19/2748	44/9376	1.4733359798862	DYNC1H1/CREB3L2/ARHGDIB/ADCY9/RAB5B/VAMP2/DCTN1/DYNC1LI2/DYNC2H1/DYNC1I2/RAB5A/ARHGDIA/CREB5/CREB1/CREB3/ADCY6/AQP3/PRKACB/ADCY3	2.02633498954842
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	52/2748	142/9376	1.24944133505546	PPP3CA/ITPR3/TGFBR2/CYLD/GAB2/FYN/PPP3CC/PIK3CA/FOS/NFATC2/FOSB/IFNAR1/JAK1/TAB2/BLNK/ATP2A2/TNFRSF1A/IL1R1/TGFBR1/PIK3R1/MAPK1/FOSL2/MAPK8/PPP3CB/JUNB/JUND/MAP2K7/MAP3K14/STAT1/TRAF6/RELA/CREB1/AKT2/NFATC1/ITPR1/FOSL1/IKBKB/ITPR2/TMEM64/STAT2/PIK3R3/IFNGR1/CHUK/CTSK/NFKB2/MAP2K1/MAPK10/SOCS3/PIK3CB/TYK2/IL1A/ITGB3	1.92850341333617
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	28/2748	70/9376	1.36477438136827	ACSL3/IRS2/ADIPOR1/SLC2A1/ACSL1/LEPR/TNFRSF1A/JAK2/PTPN11/MAPK8/APPL1/PPARA/PRKAG2/MTOR/CPT1A/PRKAA1/STAT3/PRKAB2/RELA/AKT2/RXRA/IKBKB/ACACB/TRADD/CHUK/MAPK10/SOCS3/PRKAA2	1.97239811145032
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	130/2748	388/9376	1.14317441738321	CAPN2/GNAQ/WNT5A/MT-ND4L/COX7A1/PPP3CA/TUBA4A/MT-ND5/MT-ND3/WNT2/KLC3/MT-ND2/ITPR3/MT-ND4/MT-CO2/MT-CYB/KIF5B/RB1CC1/ADAM10/IRS2/MT-CO1/MT-ATP8/RTN4/TUBA1A/ULK1/MT-ATP6/DVL1/MT-ND1/MT-CO3/KLC1/PTGS2/PPP3CC/SLC39A6/APC/FZD6/PIK3CA/TUBB6/SLC39A14/APBB1/NDUFA4L2/WNT11/RTN3/SLC39A13/ATF6/WNT2B/GSK3B/EIF2AK3/ATP2A2/DKK2/LRP1/TNFRSF1A/ATF4/SLC39A8/WNT7A/FZD1/DKK1/SLC39A10/SLC39A9/MCU/APP/MT-ND6/PIK3R1/MAPK1/BRAF/TUBB2A/MAPK8/PSEN1/ULK2/PPP3CB/INSR/PIK3C3/AXIN1/SLC11A2/ATG13/CSNK1A1/MTOR/APH1B/MAP2K7/ATG14/ATG2B/PIK3R4/NCSTN/ADAM17/BECN1/CDK5R1/WNT10A/PLCB4/NRAS/RELA/AKT2/WNT9A/RAF1/MAP3K5/CALM2/ERN1/ITPR1/ARAF/CSNK2A1/BACE1/FZD7/WIPI1/IKBKB/ITPR2/CSNK1E/PIK3R3/XBP1/SLC39A11/RYR3/PLCB1/WNT6/CHUK/LRP5/LPL/KLC4/MAP2K1/ATG2A/UQCRHL/MAPK10/EIF2AK2/PLCB3/PIK3CB/DDIT3/TPTEP2-CSNK1E/KLC2/CHRM5/CALM1/IL1A/FZD8/APAF1/WNT5B	1.85460961912734
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	39/2748	103/9376	1.29189807945054	GNAQ/TGFBR2/MAP2K4/PIK3CA/FOS/SMAD2/PPP2R2A/TNFRSF1A/TGFBR1/PIK3R1/MAPK1/GNA15/GNA11/MAPK8/IRAK4/CFLAR/PPP2R2B/PPP2CB/PPP2R2D/SERPINE1/TRAF6/PLCB4/RELA/PPP2R1A/AKT2/IKBKB/IRAK1/PIK3R3/IFNGR1/PLCB1/BDKRB2/CHUK/GNAL/MAPK10/PLCB3/PIK3CB/PPP2R1B/MYD88/TICAM1	1.91797292656529
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	57/2748	158/9376	1.23088828699353	SFN/CDK6/YWHAZ/NIPBL/CCND2/STAG1/RBL2/ATRX/CDKN2B/CCND1/CDC25B/PDS5A/PRKDC/GADD45A/GSK3B/SMAD2/CDC14B/EP300/CREBBP/PPP2R5E/PPP2R5C/STAG2/WEE1/PPP2R5B/ATR/SMC1A/CDKN1A/YWHAQ/SMAD3/PDS5B/WAPL/MAU2/CDC27/PPP2CB/SMC3/ATM/CDC16/GADD45B/CDC14A/CCNH/PPP2R5A/ESCO1/ANAPC1/PPP2R1A/ORC2/SMAD4/ORC4/CDKN2D/FZR1/ABL1/CUL1/ZBTB17/YWHAG/PPP2R5D/PPP2R1B/MDM2/RBL1	1.88458116234088
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	26/2748	65/9376	1.36477438136827	MBOAT2/DGKB/AGPAT2/PLPP2/MBOAT1/DGKA/PLPP1/LPIN3/LPIN1/AGPAT3/DGKH/LCLAT1/GPAT4/PLPP3/LPIN2/DGKI/PNPLA2/DGKE/LPL/TKFC/AGK/GPAT3/CEL/LIPG/DGKQ/GPAT2	1.90013998554373
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	33/2748	86/9376	1.30923123794049	GNAQ/CAMK2D/KCNMB4/ITPR3/KCNMA1/CREB3L2/RIMS2/ADCY7/SLC2A1/PCLO/ATP1B1/ADCY9/ATP1A1/TRPM4/VAMP2/ATF4/ATP1A4/GNA11/KCNN4/PRKCA/CREB5/PLCB4/CCK/CREB1/CREB3/ATF2/ADCY6/RAPGEF4/PLCB1/PRKACB/KCNMB3/ADCY3/PLCB3	1.85492980789953
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	21/2748	51/9376	1.40491480434969	LPCAT2/PLAAT2/PLA2G4A/PLD1/PLPP2/PAFAH1B1/PAFAH1B2/PEDS1/PLB1/PLD3/PLPP1/LPCAT4/SELENOI/PLA2G12A/CEPT1/PLPP3/AGPS/PLA2G6/GDPD3/PAFAH2/TMEM86B	1.86692587919854
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	11/2748	23/9376	1.6317954559838	B4GALT2/POMGNT1/FKTN/CRPPA/POMT2/B4GALT1/RXYLT1/FKRP/POMK/POMGNT2/LARGE1	1.95329438392022
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	11/2748	23/9376	1.6317954559838	PCYOX1/HMGCR/NUS1/MVD/PDSS2/HMGCS1/ZMPSTE24/IDI1/GGPS1/ICMT/CHURC1-FNTB	1.95329438392022
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	22/2748	54/9376	1.39004798102324	REV3L/USP1/POLK/ERCC1/ATR/REV1/PMS2/WDR48/POLI/POLH/FAAP100/FANCM/PALB2/BRCA1/FANCC/BRCA2/RPA4/EME2/FAN1/TOP3B/HES1/SLX4	1.85081545502407
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	37/2748	99/9376	1.27516798259156	GNAQ/CAMK2D/ITPR3/PLA2G4A/PPP1CB/ADCY7/SRC/PIK3CA/P2RY2/PRKCH/ADCY9/TRPV3/IL1R1/PIK3R1/MAPK8/NGF/IL1RAP/PRKCA/PLCB4/HRH1/CALM2/ITPR1/PLA2G6/ADCY6/ITPR2/PIK3R3/PLCB1/BDKRB2/PRKACB/MAPK10/ADCY3/PLCB3/PIK3CB/PRKCE/CALM1/PLCG1/TRPV1	1.77220709662675
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2748	75/9376	1.31928190198933	GSTO2/ERBB2/PIK3CA/BCL2L1/REV3L/ABCC2/MGST1/XIAP/PIK3R1/MAPK1/TOP2B/ERCC1/CDKN1A/MSH3/ATM/BIRC2/AKT2/MAP3K5/MGST2/POLH/XPA/ATP7A/PIK3R3/BIRC3/BRCA1/PIK3CB/MDM2/GSTM2/APAF1	1.78748688469382
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	9/2748	18/9376	1.70596797671033	LMBRD1/TCN2/MTR/MMUT/HCFC1/ZNF143/MMAA/ZNF76/ABCD4	1.93033411548871
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	42/2748	115/9376	1.24609834820581	GNAQ/CAMK2D/ITPR3/ACHE/FYN/CREB3L2/ADCY7/GNB1/PIK3CA/FOS/ADCY9/SLC18A3/ATF4/PIK3R1/JAK2/MAPK1/GNB5/GNA11/PRKCA/CREB5/PLCB4/NRAS/CREB1/AKT2/KCNJ2/CREB3/KCNQ5/ITPR1/ADCY6/ITPR2/PIK3R3/KCNQ1/GNGT1/PLCB1/KCNQ3/MAP2K1/PRKACB/ADCY3/GNB2/PLCB3/PIK3CB/CHRM5	1.70974534252398
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	32/2748	85/9376	1.28449353540543	ENPP1/NT5E/AK4/UPP1/AMPD3/NME3/GUK1/NT5C2/ENTPD4/RRM2B/LACC1/ADSS2/NME7/TK2/CDA/CTPS1/CMPK1/DCTD/CANT1/GDA/ENTPD5/AK9/IMPDH1/UCK2/ADK/NT5DC4/UPP2/ENTPD2/CTPS2/ADSS1/NUDT16/AK8	1.69649813923464
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	29/2748	76/9376	1.30192292959473	GNAQ/CAMK2D/MYLK/ITPR3/EZR/ADCY7/ATP1B1/ADCY9/ATP1A1/ATP1A4/ACTB/PRKCA/KCNJ15/SLC9A1/PLCB4/SLC4A2/KCNJ2/KCNJ16/CALM2/ITPR1/ADCY6/ITPR2/KCNQ1/PLCB1/PRKACB/ADCY3/PLCB3/CALM1/ACTG1	1.70162622916144
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	16/2748	38/9376	1.4366046119666	SFN/NEDD4L/NR3C2/PIK3CA/ATP1B1/ATP1A1/ATP1A4/PIK3R1/MAPK1/INSR/FXYD4/PRKCA/SCNN1A/PIK3R3/SGK1/PIK3CB	1.73642462044752
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	51/2748	144/9376	1.20839398350315	GNAQ/ITPR3/RB1CC1/ULK1/ATXN1/PUM2/RORA/PIK3CA/SLC1A6/SPTBN2/PUM1/ATP2A2/ATXN2/MCU/PIK3R1/MAPK8/BEAN1/ULK2/PIK3C3/PRKCA/ATG13/ATXN3/MTOR/OPA1/CIC/ATG14/ATG2B/PIK3R4/BECN1/VLDLR/PLCB4/AKT2/NFYA/ATXN1L/SP1/MAP3K5/ERN1/ITPR1/KAT5/WIPI1/ITPR2/KCNC3/PIK3R3/XBP1/PLCB1/ATG2A/MAPK10/PLCB3/PIK3CB/GRIA3/DAB1	1.62263663512959
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	18/2748	44/9376	1.39579198094482	MAN1A2/B4GALT2/B4GALNT3/MAN2A1/MAN1B1/MAGT1/KRTCAP2/MGAT1/STT3B/RPN1/DAD1/ALG11/MAN2A2/MGAT2/B4GALT1/STT3A/ALG12/ALG9	1.69437180702805
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	36/2748	98/9376	1.25336422778718	ATP2B4/GNAQ/CAMK1D/CAMK2D/ITPR3/CREB3L2/ADCY7/LDLR/ATP1B1/DAGLB/ADCY9/ATP1A1/ATF4/ATP1A4/ATP2B1/GNA11/PRKCA/PRKD2/CREB5/PLCB4/CREB1/CREB3/CALM2/ITPR1/ATF2/ADCY6/ITPR2/ATF1/PLCB1/PRKD1/PRKACB/ADCY3/PRKD3/PLCB3/PRKCE/CALM1	1.62343125746828
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	69/2748	201/9376	1.17126159595038	IGFBP3/JUP/MET/IGF1R/CD40/TGFBR2/PTK2/JMJD1C/CCND2/CDK14/MEIS1/ETV1/KDM6A/BCL2L1/KMT2A/SUPT3H/KLF3/PBX1/GADD45A/AFF1/RUNX1/PER2/NCOR1/ELK4/NFKBIZ/PBX3/MLF1/POLK/RUNX2/CCNT2/CDKN1A/H3-3B/BMP2K/DDB2/TFE3/HMGA2/ATM/BMI1/BIRC2/IL1R2/GADD45B/CCNT1/PAX8/SMAD1/RELA/MLLT3/ETV6/SP1/RXRA/ATF1/SIN3A/ZBTB17/DOT1L/TCF3/BIRC3/NSD2/LDB1/GZMB/PLAU/SPINT1/ZBTB16/DDIT3/SS18L1/ITGB7/GRIA3/RARA/FOXO1/MDM2/PLAT	1.58036619604306
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	23/2748	59/9376	1.33007672760467	ENPP1/NT5E/UPP1/NME3/NT5C2/DPYD/ENTPD4/RRM2B/NME7/TK2/CDA/CTPS1/CMPK1/DCTD/CANT1/ENTPD5/AK9/UCK2/CDADC1/CAD/NT5DC4/UPP2/CTPS2	1.63759165157816
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	24/2748	62/9376	1.32074940132413	CRYAB/IGF1R/IRS2/ADCY7/FOXO3/PIK3CA/RPTOR/ADCY9/PIK3R1/INSR/PRKAG2/MTOR/PRKAA1/PRKAB2/NRAS/AKT2/SIRT1/ADCY6/PIK3R3/PRKACB/ADCY3/PIK3CB/PRKAA2/FOXO1	1.63153477504539
Organismal Systems	Digestive system	hsa04970	Salivary secretion	34/2748	93/9376	1.2473744345839	ATP2B4/GNAQ/ITPR3/KCNMA1/GUCY1A1/ADCY7/ATP1B1/ADCY9/ATP1A1/VAMP2/ADRA1B/ATP1A4/ATP2B1/PRKG1/KCNN4/PRKCA/SLC12A2/CST3/SLC9A1/PLCB4/SLC4A2/GUCY1B1/CALM2/ITPR1/ADCY6/ITPR2/RYR3/PLCB1/BST1/PRKACB/ADRB2/ADCY3/PLCB3/CALM1	1.54367142909789
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	20/2748	51/9376	1.33801409938065	ERO1A/ATP6AP1/ATP6V0A1/ADCY9/ACTB/ATP6V1A/TCIRG1/PRKCA/SLC12A2/SEC61A1/KDELR3/KCNQ1/SEC61A2/ATP6V0B/ARF1/PRKACB/ATP6V0A2/ADCY3/PLCG1/ACTG1	1.55846924560149
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	73/2748	216/9376	1.15310798425791	PPP3CA/MIB2/CAMK2D/ERO1A/CD40/PTK2/MAP2K4/PPP3CC/SRC/PIK3CA/BCL2L1/LDLR/FOS/NFATC2/ATF6/TAB2/MIB1/GSK3B/EIF2AK3/RAP1A/HSP90B1/TNFRSF1A/ATF4/ROCK2/PIK3R1/JAK2/MAPK1/MAPK8/PPP3CB/VAV2/PRKCA/POU2F1/IRAK4/MAP2K7/STAT3/TRAF3/NFATC3/HSPA5/VLDLR/TRAF6/PLCB4/NRAS/RELA/AKT2/RXRA/MAP3K5/CALM2/NFATC1/ERN1/ITPR1/IKBKB/IRAK1/PIK3R3/XBP1/ARHGEF1/PLCB1/ABCA1/CHUK/TIRAP/POU2F3/TBK1/MAPK10/PLCB3/PIK3CB/DDIT3/RAP1B/CALM1/MYD88/TICAM1/APAF1/PLCG1/HSPA2/RHOA	1.46581691871912
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	12/2748	28/9376	1.46225826575172	HACD2/HACD4/ELOVL6/ELOVL1/ELOVL7/HSD17B12/ELOVL5/TECR/HACD1/HACD3/THEM4/ACOT7	1.57727384582362
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	12/2748	28/9376	1.46225826575172	B3GNT3/B4GALT4/A4GALT/B4GALT2/B3GNT2/B3GALT5/B4GALT1/ST3GAL4/FUT3/ST8SIA1/ABO/ST3GAL6	1.57727384582362
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	50/2748	144/9376	1.18469998382662	IL17RC/SCD5/MAP2K4/ADIPOR1/TAB3/FOXO3/CCND1/ACOX1/TAB2/GSK3B/TNFRSF1A/MAPK8/LPIN3/LPIN1/PPARA/FASN/PRKAG2/CPT1A/PRKAA1/IRAK4/MAP2K7/MAP3K14/TRAF3/RIPK1/SCD/TRAF6/PRKAB2/RELA/AKT2/LPIN2/MAP3K5/SIRT1/SREBF1/IKBKB/IRAK1/TRA2A/TCF7L1/ACACB/TRADD/C5/CHUK/TIRAP/TBK1/MAPK10/TCF7/PRKAA2/FOXO1/MYD88/TICAM1/IL17RA	1.43814593505471
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	15/2748	37/9376	1.38321727841379	HK2/UAP1/UGDH/HK1/GALE/GFPT1/GMDS/PGM3/UXS1/GALK2/FPGT/UAP1L1/FCSK/CMAS/GALK1	1.50382918532238
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	27/2748	73/9376	1.26194891427888	MAP1B/MDFIC/KAT2B/SERINC5/SERINC3/RANBP2/AFF4/PDCD6IP/EP300/CREBBP/APOBEC3C/BICD2/SUPT5H/CCNT2/NUP153/HGS/XPO1/VPS4B/TNPO3/ELL2/CCNT1/MLLT3/CPSF7/FURIN/MAP1S/NELFA/BICD1	1.44666933166302
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	53/2748	154/9376	1.17423769825517	ATP2B4/GNAQ/CAMK2D/PPP2R3A/TPM1/PPP1CB/CREB3L2/ADCY7/ATP1B1/ATP2A2/RPS6KA5/ADCY9/PPP2R2A/ATP1A1/ATF4/ADRA1B/PPP2R5E/PPP2R5C/ATP1A4/ATP2B1/MAPK1/PPP2R5B/PRKCA/CACNA2D3/PPP2R2B/PPP2CB/PPP2R2D/CREB5/SLC9A1/CACNG4/PPP2R5A/PLCB4/PPP2R1A/CREB1/AKT2/CREB3/CALM2/TNNT2/ATF2/ADCY6/KCNQ1/PPP2R5D/RAPGEF4/PLCB1/PRKACB/ADRB2/ADCY3/PLCB3/PPP2R1B/CACNB3/CALM1/TPM2/CACNB2	1.40375940584127
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/2748	20/9376	1.5353711790393	MSMO1/SC5D/SQLE/EBP/CYP2R1/DHCR7/CYP51A1/NSDHL/CEL	1.5432192485781
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	9/2748	20/9376	1.5353711790393	CYB5R3/CYB5R1/UAP1/UGDH/CYB5R4/GMDS/UAP1L1/CMAS/CYB5R2	1.5432192485781
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	24/2748	65/9376	1.25979173664763	GNAQ/ITPR3/CREB3L2/ADCY7/LDLR/PBX1/ADCY9/ATF4/NCEH1/PDE8A/GNA11/CREB5/PLCB4/CREB1/CREB3/SP1/ITPR1/ATF2/ADCY6/ITPR2/PLCB1/PRKACB/ADCY3/PLCB3	1.35327668808968
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	13/2748	32/9376	1.38609898107715	BIRC6/BOK/BCL2L1/TNFRSF1A/XIAP/MAPK8/BECN1/BIRC2/BIRC3/BIRC7/MAPK10/APAF1/BCL2L11	1.40867232448775
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/2748	56/9376	1.27947598253275	MAN1A2/B4GALT2/MAN2A1/MAN1B1/MAGT1/KRTCAP2/GANAB/MGAT1/MGAT3/STT3B/RPN1/DAD1/ALG11/MAN2A2/MGAT2/MOGS/B4GALT1/STT3A/ALG12/ALG9/ALG10	1.3506203888004
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	15/2748	38/9376	1.34681682371869	ENPP1/NT5E/SIRT7/NT5C2/SIRT3/NNT/NADSYN1/SIRT1/NADK2/SIRT6/BST1/NT5DC4/NUDT12/SARM1/NMNAT2	1.3793286992044
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	38/2748	109/9376	1.18948225899069	PPP3CA/HIF1A/TGFBR2/PPP3CC/RORA/FOS/NFATC2/JAK1/SMAD2/RUNX1/GATA3/IL1R1/TGFBR1/JAK2/MAPK1/AHR/MAPK8/PPP3CB/IL1RAP/SMAD3/MTOR/STAT3/STAT6/STAT1/NFATC3/STAT5B/RELA/RXRA/NFATC1/IL6ST/SMAD4/IKBKB/IFNGR1/CHUK/MAPK10/RARA/TYK2/PLCG1	1.28119422877249
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/2748	78/9376	1.22479752174075	TOB1/PFKP/XRN1/PAN3/ZCCHC7/CNOT2/CNOT4/DDX6/ENO2/CNOT1/CNOT6/MTREX/TENT4A/TENT4B/EXOSC10/CNOT6L/DIS3/EDC4/CNOT10/EDC3/DIS3L/DCP1A/PATL1/LSM1/PAN2/PABPC1L/NUDT16/PFKM	1.28365052281624
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	68/2748	205/9376	1.13176412113466	GSN/CDK6/KAT2B/YWHAZ/UBR4/CCND2/CREB3L2/DLG1/RBL2/CDKN2B/SRC/PIK3CA/CCND1/JAK1/PXN/RASA2/ATF4/EP300/CREBBP/SP100/LTBR/UBE3A/PIK3R1/MAPK1/CHD4/CDKN1A/YWHAQ/STAT3/HDAC7/GTF2A1/SCIN/USP7/TRAF3/STAT5B/H2BC5/CREB5/PKM/HDAC6/NRAS/RELA/CREB1/DDX3X/HDAC4/CREB3/GTF2E2/HDAC5/IL6ST/ATF2/VAC14/H2BC21/MAPKAPK2/PIK3R3/H2BC11/YWHAG/TRADD/H2BC4/SRF/H2BC12/NFKB2/PRKACB/EIF2AK2/PIK3CB/CCR3/MDM2/RBL1/H2BC6/RHOA/HLA-C	1.22819833969254
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	34/2748	97/9376	1.19593631357013	GNAQ/CAMK2D/ITPR3/GUCY1A1/PER3/ADCY7/GNB1/FOS/RPS6KA5/ADCY9/PER2/MAPK1/GNB5/PRKG1/PRKCA/PER1/PLCB4/CREB1/GUCY1B1/CALM2/ITPR1/ADCY6/NOS1AP/RYR3/GNGT1/PLCB1/PRKACB/ADCY3/GNB2/PLCB3/GRIA3/CALM1/GRIA4/ADCY10	1.24897275577417
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	40/2748	116/9376	1.17652963911058	GNAQ/PPP3CA/ITPR3/PLA2G4A/SLC38A1/PLD1/SLC38A2/ADCY7/PPP3CC/GNB1/SLC1A6/GLS/ADCY9/SHANK2/MAPK1/GNB5/PPP3CB/PRKCA/HOMER3/SLC1A1/PLCB4/GRIK2/ITPR1/ADCY6/ITPR2/GNGT1/TRPC1/PLCB1/GRIK1/PRKACB/ADCY3/GNB2/SLC1A3/GRK2/PLCB3/DLGAP1/HOMER1/GRIA3/GRIA4/HOMER2	1.23181045869727
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	74/2748	226/9376	1.11718256881916	ATP2B4/RRAS/EDN1/CAMK2D/SOX9/AFDN/TIAM1/PDE4D/PLD1/PPP1CB/CREB3L2/PDE10A/ADCY7/SSTR1/PIK3CA/ROCK1/ACOX1/FOS/ATP1B1/RAP1A/ATP2A2/ADCY9/ATP1A1/EP300/CREBBP/ROCK2/PPP1R12A/ATP1A4/PIK3R1/ATP2B1/MAPK1/CNGA1/BRAF/MAPK8/VAV2/EDN2/PPARA/RRAS2/CREB5/SLC9A1/RELA/CREB1/AKT2/RAF1/CREB3/CALM2/NFATC1/ADCY6/PIK3R3/HTR1B/PTCH1/RAPGEF4/FXYD1/MAP2K1/PRKACB/ADRB2/MAPK10/ADCY3/PDE3A/MYL9/TSHR/PIK3CB/BDNF/RAP1B/PLCE1/GRIA3/CALM1/GRIA4/ADCY10/ARAP3/OXTR/F2R/GIPR/RHOA	1.14817857645796
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	35/2748	102/9376	1.17076233695807	ATP2B4/GNAQ/ITPR3/KCNMA1/RAB27B/PRSS3/ADCY7/ATP1B1/RAP1A/ATP2A2/ADCY9/ATP1A1/ATP1A4/ATP2B1/RAB3D/PLA2G12A/PRKCA/SLC12A2/SLC9A1/PLCB4/SLC4A2/CCK/ITPR1/ADCY6/ITPR2/KCNQ1/TRPC1/PLCB1/BST1/ADCY3/PLCB3/RAP1B/SLC26A3/CEL/RHOA	1.11650682532929
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	34/2748	99/9376	1.17177598400306	ITGB6/ITGB4/EDN1/ITGA2/ITGAV/ITGA6/ITGB1/TPM1/DAG1/ATP2A2/LMNA/ACTB/ITGB5/SGCE/PRKAG2/ITGB8/CACNA2D3/PRKAA1/ITGA3/CACNG4/PRKAB2/TNNT2/DMD/SGCZ/SNTB2/LAMA2/ITGB7/CACNB3/PRKAA2/TPM2/ITGB3/ACTG1/CACNB2/ITGA1	1.10631554955331
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	82/2748	254/9376	1.10149113456888	ATP2B4/GNAQ/PPP3CA/CAMK1D/CAMK2D/MYLK/PLCD1/ITPR3/AVPR1A/MET/STIM1/ERBB2/ADCY7/PPP3CC/ASPH/ORAI3/VEGFA/EGFR/NFATC2/PHKA1/ATP2A2/ADCY9/ITPKC/ADRA1B/NTRK3/PLCD3/MCU/PDGFD/ATP2B1/GNA15/ERBB3/PHKA2/GNA11/PDGFB/PPP3CB/NGF/PHKB/PRKCA/VEGFB/TPCN1/STIM2/MST1R/PTGFR/FGFR2/SLN/NFATC3/PLCB4/EDNRB/HRH1/ITPKB/CALM2/NFATC1/ITPR1/ITPR2/FGFR3/PTK2B/FGF18/RYR3/PLCB1/BDKRB2/EGF/MST1/GNAL/CASQ1/PRKACB/ADRB2/ADCY3/TNNC2/SPHK2/MCOLN1/PLCB3/ORAI2/PLCE1/CHRM5/CALM1/PDGFRA/OXTR/F2R/ADORA2B/PLCG1/PHKG1/FGF7	1.05585111865944
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	12/2748	31/9376	1.32074940132413	IMMP2L/SEC62/SEC63/SRPRA/SPCS3/SEC11C/SPCS2/SEC61A1/HSPA5/TMEM208/SEC61A2/SRP14	1.15175419042587
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	150/2748	480/9376	1.06622998544396	CAPN2/GNAQ/WNT5A/MT-ND4L/COX7A1/PPP3CA/OPTN/TUBA4A/MT-ND5/MT-ND3/WNT2/KLC3/CAMK2D/MT-ND2/ITPR3/MT-ND4/MT-CO2/MT-CYB/KIF5B/RB1CC1/MT-CO1/PINK1/MT-ATP8/TUBA1A/ULK1/ATXN1/MT-ATP6/DVL1/MT-ND1/MT-CO3/KLC1/PTGS2/PPP3CC/APC/FZD6/BCL2L1/UBA1/TUBB6/SPG11/NDUFA4L2/WNT11/PRKN/ATF6/SPTBN2/WNT2B/MAP1LC3A/GSK3B/EIF2AK3/ATP2A2/DNAH5/DKK2/TNFRSF1A/ATF4/WNT7A/FZD1/HTT/ATXN2/DKK1/DCTN1/MCU/APP/MT-ND6/MAPK1/BRAF/PRNP/TUBB2A/MAPK8/PSEN1/UBE2G1/ULK2/PPP3CB/WDR41/PIK3C3/CHMP2B/AXIN1/PRKCA/ATG13/ATXN3/RAB5A/CSNK1A1/MTOR/ZFYVE1/UBC/MAP2K7/ATG14/ATG2B/PIK3R4/GPX8/GPR37/DNAH7/MFN2/BECN1/ACTR10/HSPA5/DNAH11/CDK5R1/WNT10A/DNAH14/MFN1/PLCB4/NRAS/ALS2/RELA/WNT9A/RAF1/DNAL1/ATXN1L/MAP3K5/CALM2/ERN1/ITPR1/DERL1/ARAF/CSNK2A1/FZD7/WIPI1/ITPR2/CSNK1E/XBP1/RYR3/PLCB1/ACTR1B/WNT6/LRP5/UBE2J1/GPX1/DNALI1/KLC4/TBK1/MAP2K1/ATG2A/UQCRHL/MAPK10/PLCB3/DDIT3/TPTEP2-CSNK1E/KLC2/BDNF/CHRM5/GRIA3/CALM1/GRIA4/IL1A/DNAH1/FZD8/APAF1/MAP3K10/PLCG1/WNT5B/DNAH12	0.959136997522061
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	19/2748	53/9376	1.22314685122628	ATP2B4/GNAQ/CLTB/ATP1B1/ADCY9/ATP1A1/ATP1A4/ATP2B1/AP2B1/DNM2/PRKCA/CLTC/PLCB4/ADCY6/PLCB1/BDKRB2/PRKACB/PLCB3/DNM3	1.04894715213874
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	31/2748	91/9376	1.16230785226418	PPP3CA/DAPP1/PPP3CC/PIK3CA/SOS1/FOS/NFATC2/SOS2/BLNK/GSK3B/CD81/PIK3R1/MAPK1/IFITM1/PPP3CB/VAV2/INPPL1/MALT1/NFATC3/NRAS/RELA/AKT2/RAF1/NFATC1/IKBKB/PIK3R3/CHUK/MAP2K1/PIK3CB/BANK1/CD22	1.00177923568692
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	17/2748	47/9376	1.23410449379046	IRS2/PIK3CA/HK2/PIK3R1/MAPK1/MAPK8/INSR/MTOR/SOCS4/PKM/HK1/IKBKB/PIK3R3/MAPK10/SOCS3/PIK3CB/PRKCE	1.03596214288363
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	39/2748	117/9376	1.13731198447356	CHD3/ARID1B/BPTF/BAZ2B/RSF1/H2AC6/MBD2/PBRM1/EPC1/ACTB/ARID1A/GATAD2A/INO80/EP400/BICRAL/SMARCC2/ARID2/SMARCA2/EPC2/BAZ1B/TRRAP/CHD4/SMARCA4/BAZ2A/BICRA/BAZ1A/CDK2AP1/BRD9/INO80E/KAT5/PHF6/MEAF6/MACROH2A2/GATAD2B/SS18L1/SMARCD3/YY2/INO80C/ACTG1	0.962325701802493
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	14/2748	38/9376	1.25702903547077	HK2/UAP1/GNPDA2/UGDH/HK1/GALE/GFPT1/PGM3/UXS1/GALK2/FPGT/UAP1L1/FCSK/GALK1	1.02223277796129
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/2748	14/9376	1.46225826575172	B4GALT4/B4GALT2/B3GNT2/CHST2/B4GALT1/ST3GAL1	1.11446680571096
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	12/2748	32/9376	1.27947598253275	PFKP/B4GALT2/HK2/HK1/GALE/B4GALT1/GALM/GALK1/GANC/PFKM/GAA/MGAM	1.01966102281488
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	37/2748	112/9376	1.12715741318361	LAMB3/LAMA3/LAMC1/ITGA6/ITGB1/CD40/LAMB2/LAMA5/BCL2L1/LDLR/JAK1/TAB2/TNFRSF1A/LAMB4/XIAP/JAK2/MAPK1/MAPK8/LAMC2/IRAK4/STAT3/LAMB1/STAT1/BIRC2/TRAF6/RELA/AKT2/IKBKB/IRAK1/IFNGR1/BIRC3/CHUK/BIRC7/MAPK10/LAMA2/TYK2/MYD88	0.87167416613465
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	16/2748	45/9376	1.21313278343846	ABCA5/ABCC2/ABCA12/ABCB8/ABCD3/ABCA2/ABCC10/ABCB10/ABCA1/ABCB7/ABCA10/ABCD4/ABCA4/ABCB9/DEFB1/ABCA3	0.922773621852059
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/2748	33/9376	1.24070398306206	VTI1A/VAMP2/STX11/SNAP23/VAMP4/STX3/STX7/STX16/BET1L/STX19/STX8/STX2	0.891866445534916
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	36/2748	110/9376	1.11663358475586	IGF1R/ADCY7/CPEB4/PIK3CA/CPEB2/CDC25B/ADCY9/RPS6KA2/PIK3R1/MAPK1/BRAF/MAPK8/RPS6KA3/SPDYA/STK10/CDC27/CDC16/RPS6KA6/ANAPC1/SPDYE2/AKT2/RAF1/ARAF/ADCY6/FZR1/PIK3R3/CPEB3/SPDYE1/MAP2K1/PRKACB/MAPK10/ADCY3/SPDYE21/PIK3CB/SPDYE5/SPDYE18	0.792276129250527
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	22/2748	65/9376	1.154809091927	GNAQ/ITPR3/PIK3CA/PIK3R1/MAPK1/ESR2/GNA11/KCNN4/PRKCA/PLCB4/NRAS/AKT2/RAF1/ITPR1/ITPR2/GPER1/PIK3R3/TRPC1/PLCB1/MAP2K1/PLCB3/PIK3CB	0.806413390635632
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	20/2748	59/9376	1.15658845878667	IRS2/PLAAT2/PTGS2/ADCY7/PIK3CA/ADCY9/PIK3R1/PRKG1/INSR/ABHD5/AKT2/ADCY6/PIK3R3/CIDEC/PNPLA2/PRKACB/ADRB2/ADCY3/TSHR/PIK3CB	0.776873773269049
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	51/2748	160/9376	1.08755458515284	ALCAM/SLITRK6/CD99/ITGAV/ITGA6/SDC4/ITGB1/CD40/NRXN3/GLG1/CDH1/SDC1/PTPRM/PTPRF/F11R/VTCN1/CLDN4/PTPRD/CD276/NLGN1/NECTIN3/CLDN1/CLDN9/CD99L2/NRCAM/OCLN/ITGB8/NEO1/CDH2/CXADR/PVR/CLDN12/NCAM2/PTPRS/NLGN4X/CLDN15/VCAN/NECTIN2/SDC3/CADM1/CLDN3/ITGB7/IGSF11/CLDN6/SDC2/CDH5/NLGN3/CD274/CADM3/HLA-C/CD22	0.7192343246314
Organismal Systems	Endocrine system	hsa04924	Renin secretion	23/2748	69/9376	1.13731198447356	GNAQ/PPP3CA/EDN1/ITPR3/KCNMA1/GUCY1A1/PPP3CC/PPP3CB/EDN2/PLCB4/CREB1/KCNJ2/GUCY1B1/CALM2/ITPR1/ADCY6/ITPR2/PLCB1/PRKACB/ADRB2/PDE3A/PLCB3/CALM1	0.73710759258383
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	34/2748	105/9376	1.10481735634574	ITGB6/ITGB4/ITGA2/ITGAV/ITGA6/ITGB1/TPM1/ADCY7/DAG1/ATP2A2/ADCY9/LMNA/ACTB/ITGB5/SGCE/ITGB8/CACNA2D3/ITGA3/CACNG4/TNNT2/ADCY6/DMD/SGCZ/PRKACB/SNTB2/ADCY3/LAMA2/ITGB7/CACNB3/TPM2/ITGB3/ACTG1/CACNB2/ITGA1	0.695452245055219
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/2748	57/9376	1.13731198447356	ACSL3/HACD2/HACD4/SCD5/ACOX1/ACSL1/ELOVL6/ELOVL1/FASN/ELOVL7/CPT1A/HSD17B12/ELOVL5/SCD/TECR/HACD1/ACSF3/HACD3/ACADSB	0.669520637284217
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	33/2748	103/9376	1.09314452876585	PPP2R3A/PPP1CB/SMG1/PPP2R2A/SMG6/PPP2R5E/PPP2R5C/UPF2/PPP2R5B/SMG7/UPF3A/SMG5/RNGTT/RNMT/PPP2R2B/PPP2CB/MSI2/PPP2R2D/PPP2R5A/PCF11/PPP2R1A/SYMPK/CASC3/CPSF7/SRRM1/CPSF2/PPP2R5D/WDR33/NCBP1/PABPC1L/GLE1/BCL2L2-PABPN1/PPP2R1B	0.612024185862592
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	12/2748	35/9376	1.16980661260137	PFKP/HK2/ALDOC/SORD/HK1/GMDS/ENOSF1/FPGT/TKFC/PFKFB4/FCSK/PFKM	0.648029366640737
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	60/2748	193/9376	1.06070547774736	GNAQ/TIAM1/PTK2/ADCY7/SRC/GNB1/FOXO3/PIK3CA/SOS1/ROCK1/SOS2/PXN/GSK3B/RAP1A/ADCY9/ROCK2/PIK3R1/JAK2/MAPK1/GNB5/BRAF/SHC3/VAV2/CCL27/STAT3/STAT1/STAT5B/PLCB4/NRAS/RELA/CXCL14/CXCL16/AKT2/RAF1/GRK4/SHC1/IKBKB/ADCY6/STAT2/PIK3R3/PTK2B/PARD3/GNGT1/PLCB1/CHUK/MAP2K1/CXCR6/PRKACB/ADCY3/GNB2/GRK2/PLCB3/PIK3CB/XCR1/XCL1/RAP1B/CCR3/XCL2/PLCG1/RHOA	0.548677304232765
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	58/2748	187/9376	1.0582475149647	NEK7/ITPR3/ERBIN/GBP2/TAB3/BCL2L1/PKN2/TNFAIP3/TRPM7/IFNAR1/JAK1/TAB2/MAP1LC3A/PANX1/MCU/XIAP/RIPK2/MAPK1/MAPK8/TXNIP/DNM1L/ANTXR2/IRAK4/MFN2/TRAF3/STAT1/BIRC2/RIPK1/CARD18/TRAF6/MAVS/TP53BP1/NLRX1/GBP3/MFN1/PLCB4/RELA/NOD2/SUGT1/DHX33/ITPR1/IKBKB/ITPR2/STAT2/NOD1/BIRC3/PLCB1/ATG12/CHUK/TBK1/MAPK10/RNASEL/PLCB3/TYK2/MYD88/TICAM1/ANTXR1/RHOA	0.518044218999293
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	66/2748	214/9376	1.05227931273722	GNAQ/PPP3CA/ITPR3/PTK2/PPP3CC/GNB1/PIK3CA/BCL2L1/FOS/NFATC2/FBXW11/CUL4A/PXN/TAB2/AP1G1/TNFRSF1A/CUL4B/APOBEC3C/BTRC/PIK3R1/MAPK1/GNB5/WEE1/GNA11/MAPK8/PPP3CB/ATR/PRKCA/MTOR/IRAK4/MAP2K7/PAK2/CUL5/ATM/RIPK1/NFATC3/TRAF6/NRAS/RELA/AKT2/RAF1/CFL2/CALM2/NFATC1/ITPR1/AP1G2/IKBKB/ITPR2/IRAK1/DCAF1/LIMK1/CUL1/PIK3R3/PTK2B/GNGT1/TRADD/CHUK/TBK1/MAP2K1/MAPK10/GNB2/PIK3CB/CALM1/MYD88/PLCG1/HLA-C	0.498131912241179
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	9/2748	26/9376	1.18105475310715	LMBRD1/AMN/CUBN/PLB1/TCN2/BTD/SLC19A2/ABCD4/SLC19A3	0.595241978581097
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	40/2748	128/9376	1.06622998544396	ENPP1/PDE4D/NT5E/GUCY1A1/PDE10A/ADCY7/AK4/ADCY9/AMPD3/NME3/PDE8A/GUK1/FHIT/NT5C2/PRPS2/ENTPD4/RRM2B/PAPSS1/LACC1/ADSS2/NME7/PDE5A/CANT1/GDA/ENTPD5/AK9/PDE7A/IMPDH1/GUCY1B1/ADK/ADCY6/PRUNE1/NT5DC4/ADCY3/ENTPD2/PDE3A/ADSS1/NUDT16/AK8/ADCY10	0.485778720225185
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	23/2748	72/9376	1.08992398512049	CYLD/MAPK8/MAP3K1/IFIH1/ZNFX1/TRAF3/RIPK1/TRAF6/MAVS/AZI2/NLRX1/RELA/DDX3X/IKBKB/TRADD/ATG12/CHUK/OTUD5/TKFC/TBK1/TRIM25/MAPK10/TBKBP1	0.493184813427038
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	22/2748	69/9376	1.08786363732253	PPP3CA/TH/CAMK2D/PPP1CB/CREB3L2/PPP3CC/FOS/FOSB/ATF4/PPP3CB/PRKCA/CREB5/CREB1/CREB3/CALM2/MAOA/SIRT1/ATF2/PRKACB/GRIA3/CALM1/GRIA4	0.471662793533823
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/2748	17/9376	1.20421268944259	TXNRD2/MARS1/PAPSS1/MTR/SEPSECS/CTH	0.54261927217457
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/2748	93/9376	1.06393701773333	PPP3CA/MAML2/PPP3CC/FOS/NFATC2/JAK1/GATA3/NOTCH2/JAK2/MAPK1/MAPK8/PPP3CB/MAML3/STAT6/JAG1/STAT1/NFATC3/STAT5B/STAT4/RELA/NFATC1/IKBKB/IFNGR1/CHUK/MAPK10/NOTCH3/TYK2/NOTCH1/PLCG1	0.398981195056303
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	29/2748	94/9376	1.05261853882127	IL17RC/IL17RE/PTGS2/TAB3/TNFAIP3/FOS/FOSB/TAB2/GSK3B/USP25/HSP90B1/MAPK1/MAPK8/JUND/MAPK6/TRAF3/TRAF6/RELA/S100A8/FOSL1/IKBKB/TRADD/CHUK/TBK1/MAPK10/MAPK7/LCN2/TRAF3IP2/IL17RA	0.330129763789622
NA	NA	hsa04081	Hormone signaling	66/2748	219/9376	1.0282546708939	GNAQ/PTHLH/AVPR1A/ITGAV/IGF1R/IRS2/IGF2/BMPR1A/ADIPOR1/ADCY7/SSTR1/THRB/SRC/GNB1/PIK3CA/ADCY9/LEPR/ADRA1B/PRLR/PIK3R1/JAK2/GNB5/GNA15/ESR2/GNA11/PRKG1/INSR/GNA13/APPL1/GHR/STAT3/BMPR1B/CSH1/THRA/SMAD5/STAT5B/RAMP1/PLCB4/CCK/SMAD1/SMAD4/ADCY6/UCN2/GPER1/PIK3R3/NPR3/PRL/GNGT1/RAPGEF4/PLCB1/SLC16A2/CSHL1/DIO1/PRKACB/ADRB2/ADCY3/GNB2/PLCB3/TSHR/PIK3CB/ITGB3/OXTR/GIPR/CSH2/MC1R/RHOA	0.27241966586467
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/2748	71/9376	1.05721959120077	MET/ADAM10/ATP6AP1/MAP2K4/F11R/SRC/EGFR/ATP6V0A1/PTPN11/MAPK8/ATP6V1A/TCIRG1/MAP3K14/ADAM17/RELA/IKBKB/NOD1/ATP6V0B/CHUK/ATP6V0A2/MAPK10/PLCG1	0.311615096157308
Organismal Systems	Digestive system	hsa04978	Mineral absorption	19/2748	61/9376	1.06273414942611	ATP2B4/MT1E/TRPM7/ATP1B1/CYBRD1/ATP1A1/ATP1A4/ATP2B1/SLC11A2/SLC30A1/STEAP1/MT1X/MT1G/MT1F/ATOX1/ATP7A/SLC26A6/MT1H/SLC26A3	0.316504766246778
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	13/2748	41/9376	1.0818333510846	RAD51B/NBN/BABAM2/ATM/RBBP8/UIMC1/RAD52/PALB2/BRCA1/BRCA2/RPA4/ABRAXAS1/TOP3B	0.338117660761032
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	15/2748	48/9376	1.06622998544396	PIK3CA/ATP1B1/ATP1A1/HK2/ATP1A4/PIK3R1/PLCB4/HK1/AKT2/PIK3R3/PLCB1/TAS1R3/PLCB3/PIK3CB/MGAM	0.296199118764547
Human Diseases	Infectious disease: viral	hsa05162	Measles	41/2748	136/9376	1.02859833889888	CDK6/CCND2/PIK3CA/BCL2L1/CCND1/TNFAIP3/FOS/IFNAR1/JAK1/TAB2/GSK3B/PIK3R1/MAPK8/CBLB/CD46/IRAK4/STAT3/IFIH1/TRAF3/STAT1/STAT5B/TRAF6/MAVS/RELA/AKT2/CSNK2A1/RAB9A/IKBKB/IRAK1/STAT2/PIK3R3/TRADD/CHUK/TBK1/MAPK10/EIF2AK2/PIK3CB/TYK2/MYD88/IL1A/APAF1	0.21631021524418
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	33/2748	109/9376	1.03297143543929	CD40/MAP2K4/PIK3CA/FOS/IFNAR1/JAK1/TAB2/PIK3R1/MAPK1/MAPK8/IRAK4/MAP2K7/TRAF3/TOLLIP/STAT1/RIPK1/TRAF6/RELA/AKT2/IKBKB/IRAK1/STAT2/PIK3R3/CHUK/TIRAP/CTSK/TBK1/MAP2K1/MAPK10/PIK3CB/TYK2/MYD88/TICAM1	0.222938089424152
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	16/2748	52/9376	1.04982644720636	TSPO/SORT1/LDLR/NPC1/LRP1/NCEH1/OSBPL5/VAPA/LCAT/NPC2/ABCA1/CYP27A1/LPL/LRP2/STARD3/LIPG	0.23198676752154
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	21/2748	69/9376	1.03841529017151	PLA2G4A/GAB2/FYN/MAP2K4/PIK3CA/SOS1/SOS2/PIK3R1/MAPK1/MAPK8/VAV2/PRKCA/MAP2K7/NRAS/AKT2/RAF1/PIK3R3/MAP2K1/MAPK10/PIK3CB/PLCG1	0.206217994483816
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	15/2748	49/9376	1.04447018982265	TH/GPSM1/CREB3L2/RGS9/FOSB/ATF4/CREB5/CDK5R1/RELA/CREB1/CREB3/MAOA/ATF2/PRKACB/BDNF	0.20095498657235
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2748	12/9376	1.13731198447356	NECTIN4/NPC1/CD46/NCAM2	0.306458108531862
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2748	16/9376	1.06622998544396	A4GALT/B3GALT5/ST3GAL1/ST8SIA1/ABO	0.170718064791279
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	53/2748	181/9376	0.99907516868119	PPP3CA/CAMK2D/ARHGEF12/ATP6AP1/PPP3CC/SRC/ATP6V0A1/LAMP1/JAK1/RAB5B/TNFRSF1A/EEA1/EP300/CREBBP/PLK3/RIPK2/JAK2/MAPK1/MAPK8/PPP3CB/PLA2R1/PIK3C3/TCIRG1/RAB5A/CTSD/MALT1/LAMP2/IRAK4/STAT1/TRAF6/RELA/NOD2/CREB1/AKT2/RAF1/NFYA/KSR1/CALM2/RAB7A/IRAK1/CLEC7A/IFNGR1/TRADD/ATP6V0B/TIRAP/ATP6V0A2/MAPK10/SPHK2/CALM1/MYD88/IL1A/APAF1/RHOA	-0.00808963080281118
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	30/2748	103/9376	0.993767753423496	COL17A1/COL3A1/COL5A1/COL7A1/COL12A1/COL4A5/SLC1A5/SLC38A2/PRSS3/COL1A2/COL4A6/COL5A2/ATP1B1/ATP1A1/ATP1A4/KCNN4/COL1A1/SLC1A1/COL6A1/COL28A1/SLC36A4/COL9A3/COL6A2/KCNQ1/COL4A4/COL15A1/COL6A3/COL4A2/COL18A1/SLC7A7	-0.040950184488758
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	66/2748	227/9376	0.992016620818344	MT-ND4L/COX7A1/MT-ND5/MT-ND3/MT-ND2/MT-ND4/MT-CO2/MT-CYB/MET/HIF1A/MT-CO1/PTK2/MT-ATP8/GSTO2/PLD1/ABL2/MT-ATP6/MT-ND1/MT-CO3/MAP2K4/SRC/VEGFA/EGFR/FOXO3/PIK3CA/SOS1/FOS/NDUFA4L2/SOS2/MGST1/MT-ND6/PIK3R1/SLC26A2/MAPK1/PTPN11/AHR/BRAF/MAPK8/PTPRJ/NQO1/PRKD2/MAP2K7/MAP3K14/NRAS/ARNT/RELA/AKT2/RAF1/MAP3K5/MGST2/ARAF/IKBKB/ABL1/KEAP1/PIK3R3/CHUK/EGF/PRKD1/SLC26A6/PTEN/MAP2K1/UQCRHL/MAPK10/PRKD3/PIK3CB/GSTM2	-0.0783999208974955
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	63/2748	217/9376	0.990562050993098	GSTO2/KLF4/CREB3L2/ADCY7/SRC/VEGFA/EGFR/PIK3CA/SOS1/CCND1/FOS/SOS2/ADCY9/HSP90B1/RPS6KA2/ATF4/KPNA4/NOTCH2/KPNA6/MGST1/XIAP/PIK3R1/JAK2/MAPK1/ESR2/AHR/KPNA3/KLF5/RPS6KA3/PRKCA/PPARA/MTOR/KPNA1/PAQR8/PAQR7/STAT3/JAG1/STAT5B/RPS6KA6/CREB5/NRAS/ARNT/RELA/EIF4EBP1/CREB1/AKT2/RAF1/CREB3/RXRA/MGST2/ATF2/ADCY6/KPNA5/PIK3R3/FGF18/EGF/MAP2K1/PRKACB/ADRB2/ADCY3/PIK3CB/GSTM2/FGF7	-0.0905703855421669
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2748	24/9376	0.995147986414362	EXT1/HS2ST1/B3GAT3/B3GALT6/EXTL3/NDST1/XYLT2	-0.01532421132957
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2748	17/9376	1.00351057453549	CYP7B1/HSD3B7/CYP8B1/CYP27A1/CYP46A1	0.00932804618832609
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2748	17/9376	1.00351057453549	CA5B/GLUD1/CA13/CA3/CPS1	0.00932804618832609
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/2748	42/9376	0.974838843834477	ACSL3/SLC39A14/MAP1LC3A/ACSL1/SLC39A8/ATG7/PRNP/SLC11A2/GCLC/PCBP2/CP/SLC7A11	-0.105226249801427
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/2748	78/9376	0.962340909939163	ITGB1/SERPING1/FOS/MAPK1/MAPK8/C1S/IRAK4/TRAF6/RELA/CFL2/CALM2/IRAK1/NOD1/C5/TIRAP/MAPK10/C4BPB/CALM1/MYD88/IL1A/TICAM1/RHOA	-0.215042898476106
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	49/2748	173/9376	0.966386483916837	CDK6/PRSS3/DNAJC3/PIK3CA/IFNAR1/JAK1/TNFRSF1A/EP300/CREBBP/KPNA6/PIK3R1/ACTB/JAK2/MAPK1/HNRNPUL1/PRKCA/KPNA1/XPO1/IRAK4/IFIH1/TRAF3/STAT1/MAVS/NLRX1/RELA/AKT2/RAF1/IKBKB/KPNA5/STAT2/PIK3R3/IFNGR1/NUP98/TRADD/CHUK/TBK1/MAP2K1/TRIM25/SOCS3/RNASEL/EIF2AK2/PIK3CB/BCL2L2-PABPN1/TYK2/MYD88/IL1A/TICAM1/APAF1/ACTG1	-0.287326072544341
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	10/2748	36/9376	0.947759987061297	ENPP1/PYGL/HK2/PYGB/GYS1/GBE1/HK1/GANC/GAA/MGAM	-0.202201252126096
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	51/2748	180/9376	0.966715186802523	PPP1CB/SRC/PIK3CA/BCL2L1/IFNAR1/JAK1/TAB2/TNFRSF1A/SP100/TSC2/PIK3R1/JAK2/PTPN11/MTOR/POU2F1/IRAK4/IFIH1/PILRB/TRAF3/HCFC2/STAT1/BIRC2/TRAF6/MAVS/RELA/EIF4EBP1/AKT2/HCFC1/IKBKB/IRAK1/STAT2/TSC1/PIK3R3/IFNGR1/TRADD/BIRC3/C5/NECTIN2/CHUK/POU2F3/TBK1/SOCS3/RNASEL/EIF2AK2/PIK3CB/TYK2/MYD88/TICAM1/ITGB3/APAF1/HLA-C	-0.290325810882476
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2748	18/9376	0.947759987061297	ACSL3/ACSL1/FASN/ACACB/ACSF3	-0.142840302245786
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	22/2748	79/9376	0.950159379433604	CLTB/ATP6V0A1/SLC1A6/SLC18A3/VAMP2/STXBP1/AP2B1/ATP6V1A/TCIRG1/DNM2/CLTC/UNC13B/STX3/SLC1A1/STX2/SLC6A9/ATP6V0B/ATP6V0A2/SLC1A3/SYT1/DNM3/UNC13C	-0.28643647716983
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2748	37/9376	0.922144852275857	GLS/GLUD1/ADSS2/ABAT/ASL/GFPT1/CAD/ASNS/CPS1/ADSS1	-0.305520784083049
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/2748	30/9376	0.909849587578845	ABCC2/FOLR3/MTR/MTHFR/RELA/IKBKB/CHUK/DHFR2	-0.318433103386865
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	19/2748	70/9376	0.926096901642753	CD40/ABL2/FYN/CD55/EIF4G1/EIF4G3/CCND1/DAG1/ACTB/SGCE/CAV1/CXADR/ABL1/DMD/SGCZ/SNTB2/LAMA2/ACTG1/HLA-C	-0.399606822944616
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	24/2748	88/9376	0.930527987296546	CLU/SERPINB2/F3/CD59/THBD/CD55/TFPI/SERPING1/C1S/CD46/SERPINE1/F12/C7/C5/BDKRB2/PROCR/PLAU/F5/C4BPB/F8/VTN/VWF/F2R/PLAT	-0.421592490398388
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2748	23/9376	0.890070248718436	GLS/GLUD1/ASL/CAD/CPS1/NAGS	-0.339865004995435
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	24/2748	89/9376	0.920072616652765	GABRP/TRAK2/SLC38A1/SLC38A2/ADCY7/SRC/GNB1/GLS/ADCY9/GPHN/GNB5/PRKCA/ABAT/GABRB1/GABRA4/ADCY6/GABRB3/GABRE/GNGT1/SLC38A5/PRKACB/ADCY3/GNB2/GABRR2	-0.487815536829252
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2748	12/9376	0.852983988355167	VKORC1/VKORC1L1/NQO1	-0.328115925389238
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	103/2748	368/9376	0.954971204354155	MT-ND4L/COX7A1/PPP3CA/OPTN/TUBA4A/MT-ND5/MT-ND3/KLC3/MT-ND2/ITPR3/MT-ND4/MT-CO2/MT-CYB/KIF5B/RB1CC1/MT-CO1/PINK1/MT-ATP8/TUBA1A/ULK1/MT-ATP6/MT-ND1/MT-CO3/KLC1/RANBP2/PPP3CC/BCL2L1/TUBB6/SPG11/NDUFA4L2/PRKN/SETX/ATF6/MAP1LC3A/EIF2AK3/DNAH5/TNFRSF1A/ATF4/NUP214/ATXN2/TPR/DCTN1/MCU/MT-ND6/ACTB/TUBB2A/ULK2/PPP3CB/WDR41/ANG/PFN2/PIK3C3/CHMP2B/NUP153/ATG13/RAB5A/MTOR/NUP205/ATG14/ATG2B/PIK3R4/GPX8/DNAH7/BECN1/ACTR10/HSPA5/DNAH11/DNAH14/HDAC6/NRG4/ALS2/DNAL1/PFN4/MAP3K5/ERN1/DERL1/NUP155/WIPI1/POM121C/UBQLN1/XBP1/UBQLN2/NUP98/ACTR1B/MATR3/GPX1/UBQLN4/DNALI1/KLC4/NUP133/TBK1/NCBP1/ATG2A/UQCRHL/NUP188/GLE1/NUP210L/DDIT3/KLC2/DNAH1/APAF1/ACTG1/DNAH12	-0.567417602551726
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	20/2748	76/9376	0.897877882479123	ACSL3/SLC27A6/SCD5/FABP5/ACOX1/ACSL1/ME3/PPARA/CPT1A/UBC/HMGCS1/SCD/SLC27A1/RXRA/CYP8B1/SLC27A4/CYP27A1/LPL/FABP3/SORBS1	-0.575556397734637
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	56/2748	205/9376	0.932041040934427	VIM/CDK6/CD40/CCND2/MAP2K4/PIK3CA/CCND1/TNFAIP3/IFNAR1/JAK1/GADD45A/TAB2/BLNK/NCOR2/PIK3R1/MAPK8/POLK/NEDD4/CDKN1A/DDB2/IRAK4/MAP2K7/STAT3/USP7/MAP3K14/TRAF3/STAT1/RIPK1/GADD45B/TRAF6/MAVS/RELA/AKT2/CIR1/SAP30L/IKBKB/IRAK1/SIN3A/STAT2/PIK3R3/TRADD/CHUK/NFKB2/SAP30/TBK1/MAPK10/EIF2AK2/PIK3CB/TYK2/MYD88/MDM2/HES1/APAF1/BCL2L11/HLA-C/CD44	-0.633458334278027
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/2748	17/9376	0.802808459628393	CSAD/GGT6/GGT7/GGT5	-0.523963179797918
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2748	13/9376	0.78736983540477	PRKDC/DCLRE1C/XRCC4	-0.493960011825125
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/2748	21/9376	0.812365703195397	BCAT1/ENPP1/DPYD/CSAD/PANK3	-0.554246204774513
Organismal Systems	Sensory system	hsa04744	Phototransduction	7/2748	29/9376	0.823570747377403	RGS9/GNB1/CNGA1/CALM2/GNGT1/SLC24A1/CALM1	-0.612683556275153
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/2748	26/9376	0.78736983540477	PLAAT2/PLA2G4A/ACOX1/PLB1/PLA2G12A/PLA2G6	-0.699050412693571
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	63/2748	235/9376	0.91468921304469	ACSL3/MT-ND4L/COX7A1/MT-ND5/MT-ND3/MT-ND2/MT-ND4/MT-CO2/MT-CYB/MT-CO1/MT-ATP8/ARID1B/MT-ATP6/MT-ND1/MT-CO3/CREB3L2/ADCY7/SOS1/FRS2/NDUFA4L2/SOS2/RPTOR/ACSL1/ADCY9/RPS6KA2/TSC2/MT-ND6/ACTB/ARID1A/KDM3A/SMARCC2/SMARCA2/PRKG1/RPS6KA3/PRKAG2/MTOR/CPT1A/SMARCA4/KDM3B/PRKAA1/RPS6KA6/CREB5/PRKAB2/NRAS/CREB1/CREB3/MAP3K5/COX17/ATF2/ADCY6/TSC1/ZNF516/SIRT6/PNPLA2/COA1/PRKACB/UQCRHL/ADCY3/COX19/PRKAA2/ADCY10/SMARCD3/ACTG1	-0.852793295469456
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/2748	34/9376	0.802808459628393	POLR2B/POLR3A/POLR3B/POLR3GL/POLR2M/POLR1A/POLR3F/POLR3G	-0.74166973805285
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	39/2748	149/9376	0.893057061633598	GNAQ/MT-ND4L/MT-ND5/MT-ND3/MT-ND2/ITPR3/GABRP/MT-ND4/MT-ND1/PTGS2/ADCY7/GNB1/NDUFA4L2/DAGLB/ADCY9/MT-ND6/MAPK1/GNB5/MAPK8/PRKCA/GABRB1/PLCB4/ITPR1/GABRA4/ADCY6/ITPR2/GABRB3/GABRE/GNGT1/PLCB1/PRKACB/MAPK10/FAAH/ADCY3/GNB2/PLCB3/GRIA3/GRIA4/GABRR2	-0.847262020387349
Human Diseases	Substance dependence	hsa05032	Morphine addiction	23/2748	91/9376	0.862357438776653	GABRP/PDE4D/PDE10A/ADCY7/GNB1/ADCY9/PDE8A/GNB5/PRKCA/GABRB1/PDE7A/GRK4/GABRA4/ADCY6/GABRB3/GABRE/GNGT1/PRKACB/ADCY3/GNB2/GRK2/PDE3A/GABRR2	-0.849542753827337
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	12/2748	50/9376	0.818864628820961	THBS1/MET/CD40/THBS3/SDC1/HBB/LRP1/CD81/GYPC/KLRB1/MYD88/SDC2	-0.826881574316716
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2748	10/9376	0.682387190684134	BPNT2/PAPSS1	-0.647028908670734
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/2748	31/9376	0.770437150772409	ALDH3B1/ACOX1/SMOX/DPYD/CSAD/ABAT/ALDH6A1	-0.824319460839129
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/2748	23/9376	0.741725207265363	MLH3/RFC1/MSH3/PMS2/RPA4	-0.798496882778566
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2748	23/9376	0.741725207265363	ATP1B1/GLS/ATP1A1/ATP1A4/GLUD1	-0.798496882778566
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	40/2748	155/9376	0.880499600882753	THBS1/DYNC1H1/TUBA4A/ITGA2/ITGAV/ITGB1/THBS3/TUBA1A/ATP6AP1/ATP6V0A1/TUBB6/LAMP1/RAB5B/EEA1/DYNC1LI2/ACTB/ITGB5/TUBB2A/DYNC2H1/ATP6V1A/PLA2R1/DYNC1I2/PIK3C3/TCIRG1/PIKFYVE/RAB5A/HGS/LAMP2/SEC61A1/STX7/STX12/RAB7A/CLEC7A/SEC61A2/ATP6V0B/CTSL/ATP6V0A2/ITGB3/ACTG1/HLA-C	-0.965937321243701
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/2748	15/9376	0.682387190684134	SLC33A1/ST3GAL1/ST8SIA1	-0.792656944081923
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/2748	15/9376	0.682387190684134	AK4/ALPP/AK8	-0.792656944081923
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/2748	63/9376	0.812365703195397	ERCC6/CUL4A/CUL4B/UVSSA/XPC/ERCC1/DDB2/RFC1/POLR2B/CCNH/CETN2/ERCC3/XPA/POLR2M/RPA4	-0.962144828203868
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/2748	32/9376	0.746360989810771	ACOX1/BCKDHB/SUCLA2/ABAT/MMUT/ACACB/ALDH6A1	-0.925395485549442
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/2748	44/9376	0.775439989413789	GTF2F2/GTF2I/TAF1/TAF3/GTF2A1/TAF13/CCNH/TAF2/GTF2E2/ERCC3	-0.961333653134939
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	11/2748	48/9376	0.78190198932557	BCAT1/AACS/BCKDHB/ABAT/HMGCS1/MMUT/AUH/OXCT1/ACSF3/ALDH6A1/ACADSB	-0.975395632854681
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	40/2748	157/9376	0.869283045457495	COX7A1/MT-CO2/MT-CYB/IRS2/MT-CO1/MT-CO3/ADIPOR1/PIK3CA/FOS/NDUFA4L2/GSK3B/EIF2AK3/LEPR/TNFRSF1A/ATF4/PIK3R1/MAPK8/INSR/PPARA/PRKAG2/PRKAA1/PRKAB2/RELA/ITCH/AKT2/RXRA/MAP3K5/ERN1/SREBF1/IKBKB/PIK3R3/XBP1/UQCRHL/MAPK10/SOCS3/PIK3CB/DDIT3/PRKAA2/IL1A/BCL2L11	-1.06351248421115
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	43/2748	168/9376	0.873293130935052	CAPN2/CAMK2D/PLA2G4A/CYLD/SMPD1/PYGL/TNFAIP3/TRPM7/IFNAR1/JAK1/H2AC6/TNFRSF1A/XIAP/CHMP4C/JAK2/PYGB/MAPK8/GLUD1/CHMP2B/DNM1L/VPS4B/CFLAR/STAT3/STAT6/STAT1/BIRC2/RIPK1/STAT5B/STAT4/CHMP1B/CHMP3/STAT2/IFNGR1/TRADD/BIRC3/RNF103-CHMP3/MACROH2A2/MAPK10/EIF2AK2/CHMP7/TYK2/IL1A/TICAM1	-1.0670257438907
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	20/2748	83/9376	0.822153241788113	ACSL3/ACOX1/ACSL1/ABCD3/GNPAT/PEX2/CROT/FAR1/AGPS/PEX1/SLC25A17/PEX13/PEX26/PEX10/NUDT12/PEX11A/NUDT19/ABCD4/PEX7/PEX11G	-1.04787573409327
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	81/2748	308/9376	0.897294844893098	GNAQ/MT-ND4L/COX7A1/TUBA4A/MT-ND5/MT-ND3/KLC3/MT-ND2/MT-ND4/MT-CO2/MT-CYB/KIF5B/RB1CC1/MT-CO1/MT-ATP8/TUBA1A/ULK1/CLTB/MT-ATP6/MT-ND1/MT-CO3/CREB3L2/KLC1/TUBB6/NDUFA4L2/DNAH5/EP300/CREBBP/HTT/DCTN1/MT-ND6/AP2B1/TUBB2A/MAPK8/ULK2/PIK3C3/ATG13/MTOR/CLTC/NRF1/MAP2K7/ATG14/ATG2B/PIK3R4/GPX8/DNAH7/BECN1/ACTR10/CREB5/DNAH11/POLR2B/DNAH14/PLCB4/CREB1/DNAL1/CREB3/SP1/MAP3K5/ERN1/ITPR1/WIPI1/SIN3A/PLCB1/ACTR1B/GPX1/DNALI1/KLC4/ATG2A/UQCRHL/MAPK10/SLC1A3/PLCB3/KLC2/BDNF/RCOR1/GRIA3/GRIA4/DNAH1/APAF1/MAP3K10/DNAH12	-1.18008855345866
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	85/2748	323/9376	0.897877882479123	THBS1/VIM/CDK6/EZR/MET/EFNA5/IRS2/TPM1/SERPINB5/DICER1/BMPR2/SLC7A1/CCND2/ERBB2/TIMP3/PTGS2/FOXP1/VEGFA/EGFR/APC/PIK3CA/SOS1/ROCK1/CCND1/CDC25B/SOS2/RPTOR/GLS/MARCKS/RPS6KA5/EP300/CREBBP/NOTCH2/RECK/BCL2L2/PIK3R1/RDX/MAPK1/ERBB3/PDGFB/CDKN1A/PRKCA/MDM4/MTOR/DDIT4/STAT3/HMGA2/ATM/BMI1/MCL1/NRAS/SPRY2/RAF1/HDAC4/HDAC5/SIRT1/EFNA3/TNXB/SHC1/IKBKB/TNC/ABL1/PIK3R3/FGFR3/FSCN1/PTEN/BRCA1/MAP2K1/PLAU/NOTCH3/MAPK7/PIM1/PIK3CB/MMP16/PRKCE/TRIM71/IGF2BP1/NOTCH1/PDGFRA/ITGB3/MDM2/PLCG1/BCL2L11/RHOA/CD44	-1.20261762646588
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	28/2748	115/9376	0.830732232137207	GNAQ/ITPR3/PLA2G4A/PTGS2/GNB1/DUSP1/APP/MAPK1/GNB5/BRAF/PRKCA/GABRB1/PLCB4/NRAS/RAF1/MAOA/ITPR1/ARAF/ITPR2/GABRB3/HTR1B/GNGT1/TRPC1/PLCB1/MAP2K1/PRKACB/GNB2/PLCB3	-1.17597204472423
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	69/2748	268/9376	0.878446196962784	MT-ND4L/COX7A1/TUBA4A/MT-ND5/TH/MT-ND3/KLC3/CAMK2D/MT-ND2/ITPR3/MT-ND4/MT-CO2/MT-CYB/KIF5B/MT-CO1/PINK1/MT-ATP8/TUBA1A/MT-ATP6/MT-ND1/MT-CO3/KLC1/SLC39A6/BCL2L1/UBA1/TUBB6/SLC39A14/NDUFA4L2/SLC39A13/PRKN/ATF6/EIF2AK3/ATF4/SLC39A8/DUSP1/SLC39A10/SLC39A9/MCU/MT-ND6/TUBB2A/MAPK8/UBE2G1/SLC11A2/UBC/GPR37/MFN2/HSPA5/MFN1/MAP3K5/CALM2/MAOA/ERN1/ITPR1/ITPR2/KEAP1/XBP1/SLC39A11/RYR3/UBE2J1/KLC4/GNAL/PRKACB/UQCRHL/MAPK10/DDIT3/KLC2/CALM1/APAF1/PLCG1	-1.29995162029009
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/2748	59/9376	0.751782498211334	GSTO2/ODC1/MGST1/LANCL1/RRM2B/GCLC/GPX8/MGST2/GGT6/GGT7/GPX1/GGT5/GSTM2	-1.23146794278555
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/2748	43/9376	0.714126129785722	AGPAT2/PLPP2/PLPP1/PLA2G12A/PLPP3/SLC27A1/SLC27A4/ABCA1/CEL	-1.20976442334948
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/2748	87/9376	0.784353092740384	COX7A1/MT-CO2/MT-CYB/TPM1/MT-CO1/MT-CO3/ASPH/ATP1B1/ATP2A2/ATP1A1/ATP1A4/CACNA2D3/SLC9A1/CACNG4/SLC9A6/TNNT2/UQCRHL/CACNB3/TPM2/CACNB2	-1.30113132104335
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/2748	31/9376	0.660374700662065	PFKP/ALDOC/H6PD/PRPS2/PFKM/IDNK	-1.21953419109213
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	11/2748	52/9376	0.721755682454372	IGF1R/PLA2G4A/PTGS2/ADCY7/LDLR/ADCY9/INSR/ADCY6/PRKACB/ADCY3/BMP6	-1.29547666806973
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/2748	27/9376	0.631839991374198	AACS/ABAT/HMGCS1/OXCT1/L2HGDH	-1.23349861505269
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/2748	44/9376	0.69789599047241	PARP4/RFC1/PARG/NEIL1/POLG/PNKP/POLG2/OGG1/PARP3	-1.29329683565531
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/2748	18/9376	0.568655992236778	MAN2B2/MAN2C1/FUCA2	-1.17942751111304
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	51/2748	205/9376	0.848823090850996	COL3A1/MT-ND4L/COX7A1/MT-ND5/MT-ND3/CAMK2D/MT-ND2/MT-ND4/MT-CO2/MT-CYB/TGFBR2/MT-CO1/MT-ATP8/PPP1CB/MT-ATP6/MT-ND1/MT-CO3/COL1A2/SLC2A1/PIK3CA/NDUFA4L2/GSK3B/SMAD2/ATP2A2/TGFBR1/MT-ND6/PIK3R1/MAPK8/MPC1/INSR/PRKCA/PPARA/SMAD3/MTOR/CTSD/GYS1/COL1A1/PLCB4/RELA/AKT2/SP1/GFPT1/PTPA/PIK3R3/PLCB1/PTEN/UQCRHL/MAPK10/PLCB3/PIK3CB/MMP2	-1.4091486150991
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/2748	23/9376	0.59338016581229	LNPEP/CTSA/ATP6AP2/NLN	-1.2571287605617
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2748	28/9376	0.609274277396548	TH/GPHN/ALPP/PTS/DHFR2	-1.33319728128771
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	8/2748	41/9376	0.665743600667448	GABRP/GABRB1/GABRA4/GABRB3/GABRE/GRIA3/GRIA4/GABRR2	-1.38107495707814
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/2748	37/9376	0.6455013965931	GNAQ/HBB/PRKCA/PLCB4/PLCB1/PLCB3/MYD88	-1.3911307657263
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/2748	19/9376	0.538726729487474	OGDH/BCKDHB/DLST	-1.29589414433213
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/2748	75/9376	0.727879670063076	BCAT1/PFKP/ALDOC/PRPS2/MTR/ENO2/PYCR1/PKM/ASL/PGK1/ENO4/ASNS/CPS1/NAGS/PFKM/CTH	-1.52345472070343
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	13/2748	63/9376	0.704050276102678	PLAAT2/PLA2G4A/PTGS2/PTGES/PLB1/PLA2G12A/ALOXE3/PTGR3/CBR3/PLA2G6/PTGDS/GGT5/PTGR2	-1.51756102751673
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	5/2748	30/9376	0.568655992236778	PLAAT2/PLA2G4A/PLB1/PLA2G12A/PLA2G6	-1.52361156572079
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	30/2748	133/9376	0.769609613553534	PPP3CA/FYN/PPP3CC/PIK3CA/SOS1/NFATC2/SOS2/IFNAR1/PIK3R1/MAPK1/PTPN11/BRAF/SHC3/PPP3CB/VAV2/PRKCA/KLRD1/NRAS/RAF1/NFATC1/ARAF/SHC1/PIK3R3/IFNGR1/PTK2B/GZMB/MAP2K1/PIK3CB/PLCG1/HLA-C	-1.723004650773
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	17/2748	82/9376	0.707352575709163	GSTO2/UPP1/NME3/MGST1/DPYD/CES2/RRM2B/NME7/TK2/CDA/CMPK1/IMPDH1/UCK2/MGST2/CDADC1/UPP2/GSTM2	-1.71377203060187
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/2748	16/9376	0.426491994177584	ALDH3B1/MAOA	-1.47830587973108
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	16/2748	78/9376	0.699884298137573	ITGB1/PTGS2/FOS/JAK1/TAB2/JAK2/MAPK1/IRAK4/STAT1/TRAF6/RELA/IRAK1/IFNGR1/ELK1/MYD88/IL1A	-1.71373631976845
NA	NA	hsa04981	Folate transport and metabolism	5/2748	31/9376	0.550312250551721	ABCC2/FOLR3/MTR/MTHFR/DHFR2	-1.61474892134513
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/2748	66/9376	0.672047990825283	RORA/SMAD2/GATA3/SMAD3/STAT3/STAT6/STAT1/STAT4/RELA/NOD2/NFATC1/IFNGR1/IL1A	-1.72151248109901
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/2748	22/9376	0.465263993648273	ALDH3B1/CARNMT1/MAOA	-1.61679455673494
Human Diseases	Substance dependence	hsa05034	Alcoholism	44/2748	191/9376	0.785995717018374	TH/PPP1CB/CREB3L2/GNB1/SOS1/FOSB/SOS2/H2AC6/ATF4/CAMKK1/MAPK1/GNB5/BRAF/SHC3/SLC29A3/H3-3B/HDAC7/H2BC5/CREB5/HDAC6/NRAS/CREB1/RAF1/HDAC4/CREB3/HDAC5/CALM2/MAOA/ARAF/ATF2/SHC1/H2BC21/H2BC11/GNGT1/H2BC4/MACROH2A2/H2BC12/MAP2K1/PRKACB/GNB2/BDNF/CALM1/ADORA2B/H2BC6	-1.9239878317864
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2748	28/9376	0.487419421917238	ATP6V0A1/ATP6V1A/TCIRG1/ATP6V0A2	-1.74897887087505
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/2748	33/9376	0.516959992942526	BCAT1/OGDH/BCKDHB/DLST/NAGS	-1.78977999726092
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/2748	39/9376	0.52491322360318	MTHFD1L/MTR/AHCYL2/MTHFR/DHFR2/CTH	-1.91427496226492
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/2748	67/9376	0.611093006582806	PFKP/ALDH3B1/HK2/ALDOC/ENO2/BPGM/PKM/HK1/PGK1/ENO4/GALM/PFKM	-2.05700047282309
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/2748	50/9376	0.545909752547307	P4HA2/CKB/P4HA1/ODC1/SMOX/PYCR1/P4HA3/MAOA	-2.07291848219096
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/2748	36/9376	0.473879993530649	FGGY/SORD/UGDH/CRPPA/XYLB	-2.0364107528365
Organismal Systems	Digestive system	hsa04976	Bile secretion	17/2748	90/9376	0.644476791201682	ADCY7/SLC2A1/LDLR/HMGCR/ABCC2/ATP1B1/ADCY9/ATP1A1/NCEH1/ATP1A4/SLC9A1/SLC4A2/RXRA/ADCY6/SLC10A1/PRKACB/ADCY3	-2.18211494938631
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/2748	56/9376	0.548346849656893	SAR1B/RELA/RAB1B/CLK4/NFKB2/ARF1/BCL2L13/MYD88/APAF1	-2.18269902118635
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	63/2748	275/9376	0.781643509329099	MT-ND4L/COX7A1/PPP3CA/LAMC1/TUBA4A/MT-ND5/CAV2/MT-ND3/KLC3/MT-ND2/ITPR3/MT-ND4/MT-CO2/MT-CYB/KIF5B/MT-CO1/MT-ATP8/TUBA1A/MT-ATP6/FYN/MT-ND1/MT-CO3/CREB3L2/KLC1/PPP3CC/PIK3CA/TUBB6/NDUFA4L2/GSK3B/EIF2AK3/ATF4/MCU/MT-ND6/PIK3R1/MAPK1/PRNP/TUBB2A/MAPK8/PPP3CB/CAV1/HSPA5/CREB5/CREB1/CREB3/NCAM2/ITPR1/CSNK2A1/ATF2/ITPR2/C7/PIK3R3/RYR3/C5/KLC4/PRKACB/UQCRHL/MAPK10/PIK3CB/DDIT3/KLC2/NOTCH1/IL1A/APAF1	-2.36641357581435
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/2748	116/9376	0.647091301510817	PFKP/OGDH/ACOX1/HK2/ME3/ALDOC/GLUD1/H6PD/PRPS2/SUCLA2/ENO2/PKM/MMUT/HK1/DLST/PGK1/ENO4/TKFC/ALDH6A1/CPS1/PFKM/IDNK	-2.46257018342351
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/2748	83/9376	0.575507269251679	ZDHHC1/RIPK1/MAVS/RELA/IKBKB/POLR3A/POLR3B/ZDHHC11B/ZDHHC11/CHUK/POLR3GL/TBK1/POLR3F/POLR3G	-2.50111745821198
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/2748	30/9376	0.341193595342067	OGDH/SUCLA2/DLST	-2.3270638739434
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	30/2748	154/9376	0.664662848068962	BCAT1/EPRS1/AK4/NME3/GPHN/VKORC1/VKORC1L1/MTHFD1L/PANK3/NQO1/ADSS2/NME7/GCLC/ALPP/UGDH/CTPS1/CMPK1/PTS/AK9/NADSYN1/RDH11/NADK2/CAD/PPOX/RFK/DHFR2/CTPS2/ADSS1/AK8/NMNAT2	-2.70166953457939
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	66/2748	298/9376	0.755663667536121	TNFRSF12A/IL17RC/IL17RE/ACVR2A/CD40/TGFBR2/CLCF1/BMPR2/IL1RN/BMPR1A/IL36RN/IFNAR1/IL1RL2/TNFRSF21/LEPR/TNFRSF1A/PRLR/IL1R1/LTBR/TGFBR1/RELL1/NGF/IL1RAP/IL22RA1/BMP2/IFNLR1/GHR/OSMR/CCL27/BMPR1B/CSH1/IL1R2/TNFSF12/ACVR2B/IL20RB/CXCL14/CXCL16/ACKR3/IL6ST/LIFR/IFNGR1/TNFSF15/PRL/CTF1/CSHL1/INHBB/CXCR6/IL15/XCR1/IFNL3/XCL1/IL31RA/IL1RL1/IFNL2/TNFRSF10D/IL7/CCR3/BMP6/IL1A/EDA2R/IL17RA/XCL2/BMP5/ACVR1B/CSH2/TNFRSF10C	-2.75996672493279
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2748	37/9376	0.368857940910343	TH/ALDH3B1/PNMT/MAOA	-2.47674074736956
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/2748	43/9376	0.396736738769845	ACSL3/ACOX1/ACSL1/CPT1A/ACADSB	-2.55289660017892
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	10/2748	68/9376	0.501755287267746	CYP26B1/ALDH1A2/DHRS4L2/RETSAT/CYP2W1/RDH11/CYP27C1/RDH10/CYP3A5/RDH5	-2.6550439854264
NA	NA	hsa04082	Neuroactive ligand signaling	40/2748	199/9376	0.685816272044356	GNAQ/GABRP/ACHE/ADCY7/GNB1/SLC1A6/P2RY2/ADCY9/SLC18A3/ADRA1B/GNB5/GNA11/PRKCA/GABRB1/SLC1A1/PLCB4/HRH1/GRIK2/GABRA4/ADCY6/GABRB3/SLC6A9/GABRE/HTR1B/GNGT1/PLCB1/GRIK1/GNAL/PRKACB/ADRB2/ADCY3/GNB2/SLC1A3/PLCB3/CHRM5/GRIA3/GRIA4/GABRR2/ADORA2B/SLC17A9	-2.88444733165293
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	25/2748	138/9376	0.618104339387803	MT-ND4L/COX7A1/MT-ND5/MT-ND3/MT-ND2/MT-ND4/MT-CO2/MT-CYB/MT-CO1/MT-ATP8/ATP6AP1/MT-ATP6/MT-ND1/MT-CO3/ATP6V0A1/NDUFA4L2/MT-ND6/ATP6V1A/TCIRG1/ATP12A/COX17/LHPP/ATP6V0B/UQCRHL/ATP6V0A2	-2.91003384720261
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2748	66/9376	0.465263993648273	SULT2B1/CYP7B1/HSD11B1L/HSD17B12/SRD5A1/HSD11B1/STS/CYP3A5/RDH5	-2.80697993387535
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/2748	41/9376	0.332871800333724	BPGM/MAOA/SRR/CTH	-2.75642905134948
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	38/2748	195/9376	0.664890083230695	SRC/CLCN5/PIK3CA/H2AC6/CLCN3/PIK3R1/ACTB/MAPK1/ATG7/H3-3B/PRKCA/MTOR/HDAC7/H2BC5/HDAC6/PLCB4/RELA/AKT2/RAF1/HDAC4/HDAC5/H2BC21/PIK3R3/CLEC7A/H2BC11/PLCB1/C5/H2BC4/MACROH2A2/H2BC12/MAP2K1/PLCB3/PIK3CB/VWF/ITGB3/H2BC6/PLCG1/ACTG1	-3.04482505348869
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/2748	47/9376	0.362971909938369	ACYP2/ME3/PKM/ACACB/HAGH	-2.81898469598802
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/2748	36/9376	0.284327996118389	RFC1/POLA1/RPA4	-2.77009455312066
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/2748	54/9376	0.379103994824519	BCAT1/MTR/LACC1/AHCYL2/GCLC/CTH	-2.94621169253797
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/2748	31/9376	0.220124900220688	HYI/MMUT	-2.80039311210413
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/2748	44/9376	0.310175995765515	ICA1/GZMB/IL1A/HLA-C	-2.95311274825718
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/2748	38/9376	0.269363364743737	CD40/BLNK/DCLRE1C	-2.90582235571292
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/2748	100/9376	0.5117903930131	CD9/CD59/ITGA2/ITGA6/CD55/IL1R1/ITGA3/IL1R2/IL7/IL1A/ITGB3/KITLG/ITGA1/CD22/CD44	-3.16030285687714
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/2748	50/9376	0.341193595342067	CD40/LTBR/MAP3K14/IL15/ITGB7	-3.00744616309664
Organismal Systems	Sensory system	hsa04742	Taste transduction	12/2748	86/9376	0.476084086523814	ITPR3/SCNN1A/PLCB4/GABRA4/ADCY6/HTR1B/PLCB1/TAS1R3/PRKACB/ENTPD2/PLCB3/SCN2A	-3.14272015729184
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/2748	45/9376	0.303283195859615	KLRD1/GZMB/IL1A/HLA-C	-3.01648520884376
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/2748	39/9376	0.26245661180159	CD40/GZMB/HLA-C	-2.97179570502923
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/2748	46/9376	0.296690082906145	EPRS1/BLVRB/PPOX/CP	-3.07884331439378
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2748	26/9376	0.131228305900795	HES1	-2.85620439815135
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/2748	100/9376	0.477671033478894	TNFRSF1A/LTBR/IL22RA1/CCL27/IL20RB/CXCL14/ACKR3/IL6ST/XCR1/XCL1/TNFRSF10D/CCR3/XCL2/TNFRSF10C	-3.3811660022713
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/2748	70/9376	0.389935537533791	GSTO2/PTGS2/MGST1/HSD11B1L/MGST2/HSD11B1/CYP3A5/GSTM2	-3.29872396498287
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/2748	79/9376	0.388701564313747	GSTO2/ALDH3B1/MGST1/HSD11B1L/CBR3/MGST2/HSD11B1/CYP3A5/GSTM2	-3.5131619234985
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/2748	95/9376	0.430981383589979	ATP6AP1/VEGFA/ATP6V0A1/FOS/ATP6V1A/TCIRG1/ATP6V0B/CTSK/CTSL/ATP6V0A2/IL15/IL1A	-3.58916681891476
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/2748	31/9376	0.110062450110344	UGDH	-3.19560784235713
Human Diseases	Immune disease	hsa05310	Asthma	1/2748	32/9376	0.106622998544396	CD40	-3.25946329558663
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/2748	54/9376	0.252735996549679	CD40/GZMB/TSHR/HLA-C	-3.54584008598322
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/2748	99/9376	0.413567994354021	KRT24/KRT17/KRT14/DSG1/KRT16/KRT19/KRT13/KRT15/C1S/KRT27/C5/DEFB1	-3.77688912898519
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/2748	73/9376	0.327171940738968	GSTO2/ALDH3B1/MGST1/MAOA/MGST2/CYP3A5/GSTM2	-3.71583795830899
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/2748	42/9376	0.162473140639079	DLST/MAOA	-3.50261370895493
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	39/2748	238/9376	0.559098748669774	EGFR/PIK3CA/FOS/IFNAR1/JAK1/TAB2/TNFRSF1A/RPS27L/PIK3R1/MAPK1/MAPK8/C1S/PRKCA/IRAK4/STAT3/IFIH1/ADAM17/TRAF3/STAT1/TRAF6/MAVS/RELA/IL6ST/IKBKB/IRAK1/C7/STAT2/PIK3R3/C5/RPS10-NUDT3/CHUK/TBK1/MAPK10/EIF2AK2/PIK3CB/VWF/TYK2/MYD88/PLCG1	-4.43615779402352
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/2748	82/9376	0.291262825292008	KLRD1/HSPA5/CREB1/NFYA/CTSL/HSPA2/HLA-C	-4.15043443490296
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/2748	46/9376	0.0741725207265363	PSME4	-4.05294689519182
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	15/2748	143/9376	0.357895379729441	CD40/H2AC6/RO60/C1S/H3-3B/H2BC5/H2BC21/C7/H2BC11/C5/H2BC4/MACROH2A2/H2BC12/TRIM21/H2BC6	-4.98201634883416
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	60/2748	370/9376	0.553286911365514	TSPO/EDN1/LYPD6B/AVPR1A/GABRP/PGRMC2/NR3C1/PRSS3/SSTR1/THRB/P2RY2/LEPR/ADRA1B/PRLR/PGRMC1/EDN2/GHR/GABRB1/NPFFR2/CSH1/THRA/PTGFR/APELA/CCK/EDNRB/HRH1/GRIK2/GABRA4/UCN2/GABRB3/S1PR3/GABRE/HTR1B/GPR83/PRL/C5/BDKRB2/PAQR6/CSHL1/GRIK1/LYNX1/GZMA/ADRB2/NMB/GAL/TSHR/CHRM5/GRIA3/LPAR2/GRIA4/GABRR2/CHRNE/OXTR/F2R/NPW/ADORA2B/GIPR/CSH2/TRPV1/MC1R	-5.64503086286323
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/2748	183/9376	0.316955798951647	XRN1/SBDS/MDN1/DROSHA/XPO1/EFL1/WDR75/WDR36/NMD3/HEATR1/CSNK2A1/NVL/PWP2/REXO1/GNL3L/REXO2/NOL6	-6.0082566514326
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/2748	243/9376	0.308899551338497	THOC2/SNRNP200/U2SURP/SLU7/SF3B1/SF1/AQR/DDX42/CASC3/SNIP1/WBP11/DHX8/SF3B3/DHX15/TRA2A/DHX38/TCERG1/CHERP/PRPF18/U2AF1L4/NCBP1/RBMXL1	-7.02813888962828
Genetic Information Processing	Translation	hsa03010	Ribosome	3/2748	222/9376	0.0461072426137928	RPS27L/RPS10-NUDT3/MRPL41	-9.26132952580412
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	17/2748	449/9376	0.129182430307687	CAMK2D/GNB1/OR2T11/OR2T2/OR2T10/PRKG1/OR2G6/CALM2/ANO2/OR7C1/GNAL/PRKACB/ADCY3/GRK2/OR8A1/CALM1/OR2T8	-12.1758794174022