category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	61/1500	138/9376	2.76297584541063	ATP5F1E/COX7C/UQCRB/NDUFA4/COX7A2/ATP6V1G1/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/ATP5ME/ATP6V0E1/NDUFA1/ATP5PF/COX4I1/UQCR11/COX7B/COX7A2L/COX5B/NDUFB7/NDUFS6/ATP5MC3/UQCRFS1/NDUFAB1/ATP5PD/COX17/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/NDUFB4/NDUFV2/UQCRQ/NDUFS5/ATP5F1D/UQCRH/ATP5PB/COX6A1/PPA2/ATP5MF/ATP5MC1/SDHB/NDUFB11/CYCS/COX7A1/NDUFV1/ATP5PO/ATP6V1E1/NDUFB5/NDUFB3/NDUFB6/ATP6V1H/COX5A/NDUFS4/NDUFB9/PPA1/UQCRHL/LHPP/NDUFS7	9.1049033551789
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	104/1500	308/9376	2.11061471861472	ATP5F1E/COX7C/UQCRB/NDUFA4/MAPK8/POLR2L/NRF1/COX7A2/COX6C/NDUFB2/NDUFB1/RCOR1/GNAQ/COX6B1/UQCR10/AMBRA1/PSMA7/MAP3K5/NDUFA1/SEM1/ATP5PF/COX4I1/PLCB1/DCTN4/UQCR11/COX7B/PSMB1/TAF4B/COX7A2L/COX5B/NDUFB7/NDUFS6/PSMA1/CREB1/AP2B1/ATP5MC3/UQCRFS1/NDUFAB1/POLR2G/ATP5PD/ATP5F1C/NDUFC1/CREBBP/NDUFA2/NDUFA5/NDUFA12/PSMD8/ITPR1/NDUFB4/GPX1/NDUFV2/PSMD7/ACTR10/UQCRQ/NDUFS5/DCTN3/ATP5F1D/PSMA3/UQCRH/ATP5PB/PSMA5/COX6A1/POLR2B/POLR2K/PSMB7/ATG13/CASP8/PIK3C3/ATP5MC1/POLR2I/SDHB/PSMB2/NDUFB11/VDAC1/PSMC5/HTT/ATG14/PSMD4/CYCS/COX7A1/HDAC1/BAX/NDUFV1/ATP5PO/PSMA4/POLR2F/NDUFB5/WIPI1/NDUFB3/RB1CC1/NDUFB6/COX5A/NDUFS4/HIP1/NDUFB9/PSMB6/CLTB/VDAC2/PSMD1/POLR2J/DCTN5/TGM2/UQCRHL/NDUFS7	8.64891126189478
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	116/1500	368/9376	1.97031884057971	ATP5F1E/COX7C/UQCRB/BCL2/NDUFA4/NUP98/COX7A2/COX6C/NDUFB2/RAB1A/NDUFB1/COX6B1/UQCR10/AMBRA1/PSMA7/PPP3CC/MAP3K5/ACTG1/PFN1/ACTB/NDUFA1/SEM1/ATP5PF/COX4I1/RANBP2/DCTN4/UQCR11/COX7B/PSMB1/TANK/PPP3CA/HNRNPA1/RAC1/COX7A2L/COX5B/NDUFB7/NDUFS6/PSMA1/MCU/MATR3/ATP5MC3/UQCRFS1/PRKN/NDUFAB1/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/PSMD8/PPP3CB/NDUFB4/GPX1/NDUFV2/OPTN/PSMD7/ACTR10/UQCRQ/SEC13/EIF2AK3/NUP133/NDUFS5/DCTN3/NUP153/ATP5F1D/NUP214/ANXA7/PSMA3/UQCRH/ATP5PB/PSMA5/COX6A1/PSMB7/ATG13/NUP54/RAB8A/PIK3C3/ATP5MC1/SDHB/NUP88/PSMB2/NDUFB11/VDAC1/PSMC5/TBK1/ATG14/SPG11/PSMD4/NUP210/ANXA11/CYCS/MAPK14/COX7A1/BAX/NDUFV1/ATP5PO/PSMA4/NDUFB5/WIPI1/NDUFB3/RB1CC1/NDUFB6/COX5A/NDUFS4/NDUFB9/PSMB6/NCBP1/BCL2L1/PSMD1/RAB5A/NUP58/DCTN5/UQCRHL/UBQLN1/NDUFS7	8.2871003665041
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	77/1500	205/9376	2.34781138211382	ATP5F1E/COX7C/UQCRB/NDUFA4/MAPK8/CYBA/COX7A2/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/PRKCB/NDUFA1/ATP5PF/COX4I1/PLCB1/PPP1CA/UQCR11/RAC2/COX7B/PIK3R1/CAMK2D/TGFBR2/PRKCA/RAC1/COX7A2L/COX5B/NDUFB7/NDUFS6/TGFB1/NFKB1/ATP5MC3/UQCRFS1/NDUFAB1/GSK3B/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/NDUFB4/NDUFV2/UQCRQ/PPP1CB/NDUFS5/ATP5F1D/UQCRH/ATP5PB/COX6A1/MPC1/ATP5MC1/PIK3CD/SDHB/NDUFB11/VDAC1/COL3A1/PIK3CB/PDK3/MAPK14/COX7A1/NDUFV1/ATP5PO/NDUFB5/SMAD2/NDUFB3/NDUFB6/COX5A/NDUFS4/NDUFB9/MPC2/VDAC2/ATP2A3/UQCRHL/PRKCZ/NDUFS7	8.51483266241134
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	93/1500	275/9376	2.11386181818182	FYN/ATP5F1E/COX7C/UQCRB/NDUFA4/MAPK8/CYBA/COX7A2/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/PSMA7/PPP3CC/NDUFA1/SEM1/ATP5PF/COX4I1/UQCR11/RAC2/COX7B/PIK3R1/PSMB1/PPP3CA/RAC1/COX7A2L/COX5B/NDUFB7/PRKACB/NDUFS6/PSMA1/CREB1/MCU/ATP5MC3/UQCRFS1/NDUFAB1/GSK3B/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/PSMD8/ITPR1/PPP3CB/NDUFB4/NDUFV2/PSMD7/UQCRQ/EIF2AK3/NDUFS5/ATP5F1D/MAPK1/PSMA3/CSNK2A1/UQCRH/ATP5PB/PSMA5/COX6A1/C7/PSMB7/ATP5MC1/PIK3CD/SDHB/PSMB2/NDUFB11/VDAC1/NCAM1/PSMC5/PSMD4/PIK3CB/CYCS/MAPK14/COX7A1/BAX/NDUFV1/ATP5PO/PSMA4/NDUFB5/NDUFB3/NDUFB6/COX5A/NDUFS4/NDUFB9/PSMB6/CACNA1D/VDAC2/PSMD1/ATF2/UQCRHL/NDUFS7	8.1814733645538
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	81/1500	227/9376	2.2304140969163	ATP5F1E/COX7C/UQCRB/NDUFA4/MAPK8/MAP2K4/CYBA/BRAF/COX7A2/COX6C/NDUFB2/PTPRJ/NDUFB1/COX6B1/UQCR10/SOS1/MAP3K5/NDUFA1/ATP5PF/COX4I1/UQCR11/COX7B/PIK3R1/RAC1/COX7A2L/COX5B/NDUFB7/NDUFS6/SOS2/NFKB1/ATP5MC3/UQCRFS1/NDUFAB1/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/NDUFB4/NDUFV2/NFE2L2/PTPN1/UQCRQ/NDUFS5/ATP5F1D/MAPK1/UQCRH/ATP5PB/COX6A1/RAF1/MAP2K1/MGST3/ATP5MC1/PIK3CD/SDHB/NDUFB11/VDAC1/HIF1A/PIK3CB/MAPK14/COX7A1/NDUFV1/ATP5PO/NDUFB5/NDUFB3/NDUFB6/COX5A/NDUFS4/MAP3K14/NDUFB9/FOXO3/ACP1/VDAC2/KRAS/ABL2/UQCRHL/MGST1/ABL1/PTPN11/NDUFS7	8.18947057870773
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	67/1500	174/9376	2.40686590038314	MARCHF6/BCL2/MAPK8/TMEM258/SSR4/MAP3K5/SEC61G/SEC62/PDIA3/DAD1/SEC24B/SEC61B/PDIA6/RBX1/UBE2D2/SSR2/SEC31A/DNAJC1/PRKN/CRYAB/MAN1C1/MAN1A1/CUL1/UBE4B/NFE2L2/SEC13/SEC23B/EIF2AK3/PLAA/ERP29/LMAN2/OSTC/SVIP/KRTCAP2/UBE2G1/MAGT1/DNAJC3/RAD23B/NPLOC4/DDOST/EDEM3/TRAM1/CAPN2/MAN1A2/STUB1/SEC63/BAX/LMAN1/SIL1/SELENOS/NGLY1/SSR1/RPN2/SEC23A/UGGT1/MBTPS1/DNAJC5/FBXO6/ATXN3/SEC61A2/SEC24C/MOGS/RAD23A/UBQLN1/DERL2/ERLEC1/STT3B	8.17456453952724
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	53/1500	122/9376	2.71545355191257	CD3G/FYN/CD3D/CD247/CBLB/CD3E/PRKCQ/CARD11/MAPK8/ITK/PPP2R5C/NFATC2/RASGRP1/PPP2R2B/PPP3CC/SOS1/VAV1/CD8A/CD8B/DLG1/PIK3R1/PPP3CA/PAK2/LCK/GRAP2/MALT1/PPP2R2D/VAV3/SOS2/PPP2R5A/NFKB1/GSK3B/ICOS/PPP2R3A/PPP3CB/NFATC3/PPP2R3C/MAPK1/RAF1/MAP2K1/PPP2R5E/PIK3CD/NCK1/LAT/NCK2/PIK3CB/MAP3K8/MAPK14/IFNG/PPP2R2A/MAP3K14/KRAS/PTPN11	8.322859154099
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	90/1500	268/9376	2.09910447761194	ATP5F1E/COX7C/RPS27A/UQCRB/NDUFA4/MAPK8/UBA52/CALM1/COX7A2/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/PSMA7/MAP3K5/NDUFA1/SEM1/ATP5PF/COX4I1/SLC18A2/UQCR11/PARK7/COX7B/PSMB1/CAMK2D/COX7A2L/COX5B/NDUFB7/PRKACB/UBE2L3/NDUFS6/PSMA1/MCU/ATP5MC3/UQCRFS1/PRKN/NDUFAB1/TXN/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/PSMD8/ITPR1/NDUFB4/NDUFV2/NFE2L2/PSMD7/UQCRQ/EIF2AK3/NDUFS5/ATP5F1D/PSMA3/UQCRH/ATP5PB/PSMA5/COX6A1/PSMB7/UBE2L6/UBE2G1/ATP5MC1/SDHB/PSMB2/NDUFB11/VDAC1/SLC39A11/PSMC5/PSMD4/CYCS/COX7A1/BAX/NDUFV1/ATP5PO/PSMA4/NDUFB5/NDUFB3/NDUFB6/SLC39A8/COX5A/NDUFS4/NDUFB9/PSMB6/BCL2L1/VDAC2/PSMD1/UQCRHL/NDUFS7	7.96660486511622
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	82/1500	235/9376	2.18108368794326	ATP5F1E/COX7C/UQCRB/NDUFA4/COX7A2/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/ATP5ME/SOS1/MAP3K5/ACTG1/ACTB/NDUFA1/RPS6KA3/RPTOR/ARID1B/ATP5PF/COX4I1/COA1/UQCR11/COX7B/COX7A2L/COX5B/NDUFB7/PRKACB/COX14/NDUFS6/SMARCC1/SOS2/CREB1/ATP5MC3/UQCRFS1/NDUFAB1/ATP5PD/COX17/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/NDUFB4/NDUFV2/UQCRQ/NDUFS5/ATP5F1D/NDUFAF2/NDUFAF6/UQCRH/ATP5PB/COX6A1/NDUFAF7/ATP5MF/FRS2/ATP5MC1/SDHB/NDUFAF8/NDUFB11/PRKAA1/MAPK14/COX7A1/NDUFV1/ATP5PO/KDM3B/NDUFB5/NDUFB3/NDUFB6/RPS6KB1/ACSL5/COX5A/NDUFS4/NDUFB9/ACTL6A/CPT1A/COA3/KRAS/ATF2/UQCRHL/RHEB/NDUFS7	8.00195605740206
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	57/1500	142/9376	2.50907042253521	CBLB/RPS27A/PIAS1/UBE2Q1/COP1/BIRC6/UBA52/HERC1/CUL3/ELOB/ANAPC16/UBE2K/UBE2B/FBXW11/FBXW7/UBR5/NEDD4/RBX1/WWP2/UBE2D2/UBE2L3/UBE2O/HUWE1/BTRC/CUL2/UBE4A/PRKN/CDC27/UBE2H/UBE3A/UBE2E2/CUL1/UBE4B/HERC4/UBE2E1/ANAPC11/UBE2L6/UBE3C/UBE2G1/UBE2E3/CUL5/UBA2/CUL4A/STUB1/TRIP12/BRCA1/SMURF2/ELOC/SMURF1/XIAP/UBE2R2/UBA3/CDC16/UBA6/UBE2M/PPIL2/VHL	7.90746281268024
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	132/1500	480/9376	1.71893333333333	ATP5F1E/COX7C/RPS27A/UQCRB/BCL2/NDUFA4/MAPK8/DKK1/UBA52/BRAF/CALM1/COX7A2/COX6C/NDUFB2/RAB1A/NDUFB1/GNAQ/ATXN1/COX6B1/UQCR10/AMBRA1/PSMA7/PRKCB/PPP3CC/MAP3K5/NDUFA1/SEM1/ATP5PF/COX4I1/PLCB1/DCTN4/UQCR11/PARK7/COX7B/PSMB1/TANK/PPP3CA/CAMK2D/PRKCA/RAC1/COX7A2L/COX5B/NDUFB7/UBE2L3/NDUFS6/PSMA1/MCU/PSEN1/NFKB1/ATP5MC3/UQCRFS1/PRKN/NDUFAB1/GSK3B/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/PSMD8/ITPR1/PPP3CB/NDUFB4/GPX1/NDUFV2/OPTN/PSMD7/ACTR10/UQCRQ/EIF2AK3/NDUFS5/DCTN3/ATP5F1D/MAPK1/PSMA3/CSNK2A1/UQCRH/ATP5PB/PSMA5/COX6A1/RAF1/PSMB7/ATG13/UBE2L6/MAP2K1/UBE2G1/RAB8A/CASP8/PIK3C3/ATP5MC1/SDHB/PSMB2/NDUFB11/CAPN2/VDAC1/PSMC5/TBK1/HTT/ATG14/SPG11/PSMD4/CYCS/MAPK14/COX7A1/BAX/NDUFV1/ATP5PO/PSMA4/NDUFB5/WIPI1/NDUFB3/RB1CC1/NDUFB6/COX5A/NDUFS4/FASLG/HIP1/NDUFB9/PSMB6/CACNA1D/WNT5A/BCL2L1/VDAC2/ATXN3/PSMD1/RAB5A/KRAS/DCTN5/ATP2A3/UQCRHL/NDUFS7	7.05651494558793
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	58/1500	157/9376	2.30916348195329	COX7C/UQCRB/NDUFA4/MAPK8/COX7A2/COX6C/NDUFB2/NDUFB1/COX6B1/UQCR10/MAP3K5/NDUFA1/COX4I1/UQCR11/COX7B/PIK3R1/CXCL8/RAC1/COX7A2L/COX5B/NDUFB7/NDUFS6/TGFB1/NFKB1/UQCRFS1/NDUFAB1/GSK3B/NDUFC1/NDUFA2/NDUFA5/NDUFA12/NDUFB4/NDUFV2/UQCRQ/EIF2AK3/NDUFS5/UQCRH/COX6A1/CASP8/PIK3CD/SDHB/NDUFB11/PRKAA1/PIK3CB/CYCS/MAPK14/COX7A1/BAX/NDUFV1/NDUFB5/NDUFB3/NDUFB6/COX5A/NDUFS4/FASLG/NDUFB9/UQCRHL/NDUFS7	7.21905274980809
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	80/1500	253/9376	1.9764953886693	H3-3B/H3-3A/U2AF1/RPS27A/MYL12A/ELMO1/SEPTIN7/SEPTIN6/PRKCQ/FNBP1/BCL2/MAPK8/MYL12B/UBA52/CYTH1/ARPC3/ARPC2/ARPC5/RPS6KA5/ACTG1/PFN1/FOXO1/ACTB/ACTR3/RPTOR/FBXW11/PRKCE/PLCB1/PIK3R1/CAST/CXCL8/RBX1/MALT1/RAC1/UBE2D2/ATG5/BTRC/NFKB1/GSK3B/H3C4/PXN/ITPR1/CUL1/CD44/MAPK1/DIAPH1/UBE2V2/GLMN/HCLS1/TAB2/PIK3C3/WASF2/PIK3CD/CAPN2/VDAC1/TBK1/ATG14/ELMO2/SEPTIN9/PIK3CB/CYCS/NOD1/ARPC4/MAPK14/ARF1/BAX/WIPI1/RIPK1/ITGB1/MYL9/RPS6KB1/MYL11/ARPC5L/FOXO3/TRADD/BCL2L1/RBCK1/CALCOCO2/CASP4/VCL	6.87131777904394
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	109/1500	388/9376	1.75598625429553	ATP5F1E/COX7C/UQCRB/NDUFA4/MAPK8/DKK1/BRAF/CALM1/COX7A2/COX6C/NDUFB2/NDUFB1/GNAQ/COX6B1/UQCR10/AMBRA1/PSMA7/PPP3CC/MAP3K5/NDUFA1/SEM1/ATP5PF/COX4I1/PLCB1/UQCR11/COX7B/PIK3R1/PSMB1/PPP3CA/COX7A2L/COX5B/NDUFB7/NDUFS6/PSMA1/MCU/PSEN1/NFKB1/ATP5MC3/UQCRFS1/NDUFAB1/GSK3B/ATP5PD/ATP5F1C/NDUFC1/NDUFA2/NDUFA5/NDUFA12/PSMD8/ITPR1/PPP3CB/NDUFB4/NDUFV2/PSMD7/UQCRQ/EIF2AK3/NDUFS5/ATP5F1D/EIF2AK2/MAPK1/PSMA3/CSNK2A1/UQCRH/ATP5PB/PSMA5/COX6A1/RAF1/PSMB7/ATG13/MAP2K1/CASP8/ADAM10/PIK3C3/ATP5MC1/PIK3CD/SDHB/PSMB2/NDUFB11/CAPN2/VDAC1/SLC39A11/PSMC5/ATG14/PSMD4/PIK3CB/CYCS/COX7A1/NDUFV1/ATP5PO/PSMA4/NDUFB5/WIPI1/NDUFB3/RB1CC1/NDUFB6/SLC39A8/COX5A/NDUFS4/NDUFB9/PSMB6/CACNA1D/WNT5A/VDAC2/NAE1/PSMD1/KRAS/ADAM17/ATP2A3/UQCRHL/NDUFS7	6.63707375714871
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	73/1500	238/9376	1.91722128851541	RPS27/RPS21/RPL34/RPS28/RPL39/RPL37/RPL30/RPL37A/RPS29/RPL35A/RPS27A/RPL38/RPL21/RPS4X/RPL36/STAT1/RPL27A/MAPK8/RPL36AL/UBA52/RPS23/RPS13/TRAF3/RPL35/RPL6/RPL11/RPS15/PRKCB/FAU/RPL8/RPL28/RPS7/RPS8/RPL14/RPS12/JAK1/PIK3R1/RPL32/RPS24/RPS15A/CXCL8/RPL24/PRKCA/RPL3/RPS10-NUDT3/RSL24D1/RPL12/RPL7/RPL10/RPL22/NFKB1/RPLP2/RPL10A/RPS20/RPL23/C1S/RPL9/RPS27L/EIF2AK2/RPL13/MAPK1/RPS14/RPL15/C7/TAB2/RPL18/MX2/PIK3CD/TBK1/PIK3CB/MAPK14/RPL22L1/ADAM17	6.25482900942256
Genetic Information Processing	Translation	hsa03010	Ribosome	68/1500	222/9376	1.91461861861862	RPS27/RPS21/RPL34/RPS28/RPL39/RPL37/RPL30/RPL37A/RPS29/RPL35A/RPS27A/RPL38/RPL21/RPS4X/RPL36/RPL27A/RPL36AL/UBA52/RPS23/RPS13/RPL35/RPL6/RPL11/RPS15/FAU/RPL8/RPL28/RPS7/RPS8/RPL14/RPS12/RPL32/RPS24/RPS15A/MRPL20/RPL24/RPL3/RPS10-NUDT3/RSL24D1/MRPL54/RPL12/RPL7/MRPL1/RPL10/RPL22/RPLP2/RPL10A/RPS20/RPL23/MRPS21/RPL9/RPS27L/MRPL33/MRPL41/RPL13/MRPL42/MRPL51/RPS14/RPL15/RPL18/MRPL47/RPL22L1/MRPS25/MRPL52/MRPS9/MRPS15/DAP3/MRPL43	6.01851691036939
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	74/1500	250/9376	1.85019733333333	RAB11A/CBLB/GRK5/CAPZA1/SH3KBP1/ASAP1/CYTH1/ARPC3/ARPC2/ARPC5/CXCR4/EPS15/CAPZB/ACTR3/WIPF1/GBF1/ARAP2/VPS37B/ARF5/IGF1R/NEDD4/TGFBR2/IQSEC1/ACAP2/RABEP1/RAB7A/ARFGEF1/AP2B1/ARFGEF2/SMAP1/VPS4B/RAB10/CHMP2A/SMAP2/VPS36/RAB22A/MVB12B/DNM2/SNX1/RBSN/RAB8A/VPS26A/ZFYVE27/CAPZA2/AGAP1/TSG101/PDCD6IP/IL2RB/SH3GLB1/ARPC4/BIN1/SMURF2/ARF1/LDLRAP1/ARFGAP3/EPS15L1/VTA1/SMURF1/SMAD2/SNX4/GRK6/EEA1/STAM/ARPC5L/WASHC3/MVB12A/CLTB/RAB5A/WIPF2/VPS35/SPART/SNF8/PRKCI/PRKCZ	5.94604134337877
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	63/1500	214/9376	1.84014953271028	CD3G/CD3D/CD247/GNG2/CD3E/BCL2/MAPK8/NFATC2/CALM1/CXCR4/ELOB/GNAQ/CFL1/GNB1/PRKCB/PPP3CC/PDIA3/FBXW11/RAC2/PIK3R1/PPP3CA/PAK2/RBX1/PRKCA/RAC1/SAMHD1/BTRC/GNG5/GNB5/NFKB1/PXN/ITPR1/PPP3CB/NFATC3/CUL1/AP1G1/BST2/MAPK1/RAF1/ATR/MAP2K1/TAB2/CASP8/CUL5/PIK3CD/CUL4A/TBK1/PIK3CB/CYCS/MAPK14/BAX/ELOC/RIPK1/RPS6KB1/APOBEC3H/FASLG/APOBEC3C/TRADD/TRIM5/DCAF1/BCL2L1/KRAS/APOBEC3G	5.42558719086251
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	34/1500	90/9376	2.36136296296296	CD3G/CD3D/CD247/CD3E/PRKCQ/STAT1/EML4/NFATC2/RASGRP1/PPP3CC/JAK1/PIK3R1/PPP3CA/LCK/NFKB1/PPP3CB/NFATC3/MAPK1/CSNK2A1/RAF1/MAP2K1/PIK3CD/LAT/HIF1A/PIK3CB/IFNGR1/MAPK14/MAP3K3/IFNG/RPS6KB1/KRAS/ALK/PTPN11/JAK2	5.66316558502928
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	17/1500	31/9376	3.42778494623656	SRP14/SPCS2/SPCS1/SEC61G/IMMP2L/SEC62/SEC61B/SRP9/SEC11C/SEC11A/SPCS3/SRP72/SRP54/SEC63/SRPRA/IMMP1L/SEC61A2	5.90853513305007
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	42/1500	125/9376	2.100224	FYN/BCL2/MAPK8/PPP2R5C/GNAQ/PPP2R2B/PRKCB/MAP3K5/PRKCE/SGMS1/PLCB1/RAC2/PIK3R1/PRKCA/RAC1/ORMDL1/PPP2R2D/PPP2R5A/NFKB1/PPP2R3A/CERS6/CERS5/PPP2R3C/GAB2/MAPK1/NSMAF/RAF1/SPTLC2/SPTLC1/MAP2K1/PPP2R5E/PIK3CD/GNA13/PIK3CB/MAPK14/BAX/S1PR5/PPP2R2A/TRADD/KRAS/ORMDL2/PRKCZ	5.40406039916693
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	52/1500	169/9376	1.92328205128205	RPS27A/PRKCQ/BCL2/MAPK8/BIRC6/UBA52/RAB1A/AMBRA1/TAX1BP1/RPTOR/ATG7/PIK3R1/TANK/IGF1R/PRKACB/ATG5/UVRAG/MTMR3/RAB7A/HMGB1/ITPR1/OPTN/EIF2AK3/GABARAPL2/MAPK1/RAF1/ATG13/MAP2K1/RRAS2/RUBCN/RAB8A/PIK3C3/PIK3CD/PRKAA1/TBK1/ATG14/HIF1A/PIK3CB/SH3GLB1/DAPK2/VPS41/ATG10/WIPI1/IGBP1/RB1CC1/RPS6KB1/BCL2L1/WDR45B/KRAS/CALCOCO2/RHEB/GORASP2	5.28563400253278
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	65/1500	232/9376	1.75126436781609	CYRIB/TMSB4X/SSH2/MYL12A/MYL12B/BRAF/ARPC3/ARPC2/ARPC5/CXCR4/CFL1/PIP4K2A/CYFIP2/ARHGEF7/IQGAP2/SOS1/ACTG1/VAV1/ITGA4/PFN1/ACTB/ACTR3/PPP1CA/RAC2/PIK3R1/PAK2/BRK1/RAC1/MSN/MYH9/PPP1R12A/VAV3/SOS2/PDGFD/PXN/ITGAL/PPP1CB/MAPK1/DIAPH1/RAF1/FGD3/C7/MAP2K1/RRAS2/PPP1R12B/WASF2/ARHGEF6/PIK3CD/TIAM1/GNA13/F2R/DIAPH2/PIK3CB/ARPC4/CYRIA/ARHGAP35/ITGB1/MYL9/MYL11/ARPC5L/PIKFYVE/KRAS/VCL/GSN/ITGB7	5.05646596844286
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	68/1500	248/9376	1.71389247311828	RHOH/DYNLT1/MYL12A/ELMO1/BCL2/EXOC4/MAPK8/MAP2K4/MYL12B/CYTH1/ARPC3/ARPC2/ARPC5/CYFIP2/SNX9/S100A10/ACTG1/PFN1/ACTB/ACTR3/DCTN4/CXCL8/BRK1/RAC1/ABI1/RAB7A/EXOC2/ARL8B/NFKB1/TXN/ACTR10/DCTN3/LEF1/MAPK1/DNM2/RAF1/MAP2K1/TCF7/KPNA1/TAB2/CASP8/CSE1L/PIK3C3/PIK3CD/RALA/ELMO2/PIK3CB/CYCS/NOD1/ARPC4/MAPK14/VPS41/ARF1/BAX/PIK3C2A/RIPK1/MYL9/ANXA2/MYL11/DYNLT3/ARPC5L/TRADD/RAB5A/M6PR/DCTN5/KPNA3/CASP4/FYCO1	4.97220747043012
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	43/1500	138/9376	1.94767149758454	ELMO1/MAPK8/MAP2K4/NFATC2/ARPC3/ARPC2/ARPC5/GNAQ/ARHGEF7/ACTG1/VAV1/ITGA4/ACTB/ACTR3/RPS6KA3/CD8A/WIPF1/CD8B/RAC2/PIK3R1/LCK/CXCL8/RAC1/VAV3/NFKB1/GSK3B/PXN/NFATC3/MAPK1/PKN2/MAP2K1/TAB2/WASF2/PIK3CD/LAT/TBK1/ELMO2/PIK3CB/ARPC4/MAPK14/ITGB1/ARPC5L/WIPF2	4.89425729820773
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	47/1500	158/9376	1.85937552742616	STAG1/PPP2R5C/CCNH/ANAPC16/TFDP2/CCND3/STAG2/CDK6/NIPBL/YWHAB/CDC14A/RB1/RBX1/PDS5A/TGFB1/YWHAZ/PPP2R5A/GSK3B/CDC27/PRKDC/CREBBP/CUL1/SMC1B/WAPL/ANAPC11/CDKN1B/ATR/RBL1/PPP2R5E/SMC3/BUB3/PDS5B/RBL2/HDAC1/SMAD2/GADD45A/SFN/MAU2/CDKN2A/CDC16/ZBTB17/MTBP/ESCO1/ORC2/ABL1/CDC7/ORC4	4.75413585046259
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	28/1500	77/9376	2.2729696969697	RUNX1/BRAF/SOS1/CDK6/STAT5B/PIK3R1/RB1/TGFBR2/TGFB1/SOS2/NFKB1/GAB2/MAPK1/RAF1/CDKN1B/MAP2K1/PIK3CD/PIK3CB/HDAC1/BAX/GADD45A/MECOM/CDKN2A/BCL2L1/KRAS/ABL1/PTPN11/BCR	4.89467339524862
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	46/1500	157/9376	1.83140552016985	NFATC2/CALM1/CCND3/ETS1/PPP3CC/CDK6/FOXO1/FBXW11/PPP1CA/PIK3R1/PPP3CA/CXCL8/RB1/TGFBR2/BTRC/TGFB1/MCU/NFKB1/ITPR1/PPP3CB/NFATC3/PPP1CB/MAPK1/RAF1/ATR/HIPK3/RBL1/MAP2K1/RRAS2/PIK3CD/RBL2/CAPN2/VDAC1/HIPK2/PIK3CB/MAPK14/SMAD2/LIN52/GADD45A/RASSF5/FOXO3/CACNA1D/CDKN2A/VDAC2/KRAS/RHEB	4.58457663181437
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	43/1500	144/9376	1.86651851851852	MAPK8/PUM2/GNAQ/ATXN1/AMBRA1/PSMA7/PRKCB/MAP3K5/SEM1/PLCB1/PUM1/PIK3R1/PSMB1/PRKCA/RORA/PSMA1/MCU/ATXN10/PSMD8/ITPR1/PSMD7/OPA1/PSMA3/PSMA5/PSMB7/ATG13/PIK3C3/PIK3CD/PSMB2/VDAC1/PSMC5/ATG14/PSMD4/PIK3CB/CYCS/PSMA4/WIPI1/RB1CC1/PSMB6/VDAC2/ATXN3/PSMD1/ATP2A3	4.57287795465872
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	22/1500	56/9376	2.45561904761905	MGAT4A/TMEM258/MGAT5/DAD1/MAN2A1/B4GALT1/MAN1C1/MAN1A1/ST6GAL1/ALG13/FUT8/ALG5/OSTC/KRTCAP2/MAGT1/DHRSX/DDOST/MAN1A2/DPM3/RPN2/MOGS/STT3B	4.76773601874328
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	31/1500	93/9376	2.08355555555556	FYN/MYL12A/RAP1B/MYL12B/RAP1A/PTPRJ/YES1/ACTG1/ACTB/RAC2/FER/IGF1R/CCM2/TGFBR2/RAC1/PDCD10/NLK/CREBBP/PTPN1/LEF1/MAPK1/CSNK2A1/TCF7/WASF2/SMURF2/HEG1/SMURF1/MYL9/MYL11/ACP1/VCL	4.58275770446631
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	25/1500	70/9376	2.23238095238095	RAP1B/RAP1A/BRAF/ELOB/ETS1/SOS1/PIK3R1/RAPGEF1/PAK2/RBX1/RAC1/TGFB1/SOS2/CUL2/CREBBP/MAPK1/RAF1/MAP2K1/PIK3CD/HIF1A/PIK3CB/ELOC/KRAS/PTPN11/VHL	4.51638428066273
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	30/1500	93/9376	2.01634408602151	CD3G/STAT4/CD3D/CD247/MAML2/CD3E/PRKCQ/STAT1/MAPK8/NFATC2/PPP3CC/STAT5B/JAK1/PPP3CA/LCK/NFKB1/PPP3CB/NFATC3/IL12RB2/MAPK1/MAML3/JAK3/LAT/IL2RB/IFNGR1/MAPK14/IL4R/IFNG/RUNX3/JAK2	4.29849551019631
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	39/1500	133/9376	1.8329022556391	HCST/FYN/CD247/GZMB/NFATC2/BRAF/CD48/PRKCB/PPP3CC/SOS1/VAV1/PRF1/RAC2/PIK3R1/PPP3CA/LCK/PRKCA/RAC1/KLRC4-KLRK1/VAV3/SOS2/KLRD1/PPP3CB/ITGAL/MAPK1/RAF1/MAP2K1/PIK3CD/LAT/PIK3CB/IFNGR1/IFNG/SH2D1B/FASLG/KLRC1/CD244/SH2D1A/KRAS/PTPN11	4.22174304114317
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	36/1500	120/9376	1.8752	ARHGDIB/CAMK4/RAP1B/BCL2/MAPK8/RAP1A/BRAF/CALM1/RPS6KA5/SOS1/MAP3K5/RPS6KA3/PIK3R1/CAMK2D/RAPGEF1/RAC1/SOS2/PSEN1/NFKB1/GSK3B/MAP2K5/MAPK1/RAF1/MAP2K1/FRS2/PIK3CD/PIK3CB/KIDINS220/MAPK14/MAP3K3/BAX/FASLG/FOXO3/KRAS/ABL1/PTPN11	4.2108005698466
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	58/1500	224/9376	1.61847619047619	CD3G/CD3D/CD3E/MAPK8/MAP2K4/NFATC2/TSPO/ANAPC16/CCND3/ETS1/PPP3CC/STAT5B/RELB/DLG1/CRTC3/JAK1/PIK3R1/PPP3CA/LCK/KAT2B/RB1/TGFBR2/PRKACB/TGFB1/CREB1/NFKB1/CDC27/CREBBP/PPP3CB/NFATC3/ITGAL/POLB/MAPK1/ANAPC11/ATR/MAP2K1/CRTC1/BUB3/PIK3CD/JAK3/VDAC1/IL2RB/PIK3CB/MAP3K3/BAX/VAC14/SMAD2/MAP3K14/TRRAP/XIAP/CDKN2A/BCL2L1/VDAC2/CDC16/KRAS/ATF2/FDPS/IL15	4.08853201348902
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	35/1500	116/9376	1.88597701149425	RHOH/MYL12A/RAP1B/ITK/MYL12B/RAP1A/CYBA/CXCR4/PRKCB/CD99/ACTG1/VAV1/ITGA4/ACTB/RAC2/PIK3R1/PRKCA/RAC1/MSN/VAV3/PXN/ITGAL/TXK/PIK3CD/PIK3CB/PECAM1/MAPK14/ARHGAP35/ITGB1/MYL9/MYL11/RASSF5/PTPN11/VCL/VCAM1	4.19009981442844
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	26/1500	77/9376	2.11061471861472	STAT1/MAPK8/BRAF/CDK6/JAK1/RAC2/PIK3R1/RB1/TGFBR2/RAC1/TGFB1/NFKB1/MAPK1/RAF1/MAP2K1/ARHGEF6/PIK3CD/RALA/PIK3CB/BAX/SMAD2/RPS6KB1/GADD45A/CDKN2A/BCL2L1/KRAS	4.27040512316642
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	25/1500	73/9376	2.14063926940639	EML4/BRAF/PRKCB/SOS1/CDK6/STAT5B/PIK3R1/STK4/RB1/PRKCA/SOS2/MAPK1/RAF1/MAP2K1/PIK3CD/JAK3/PIK3CB/BAX/GADD45A/RASSF5/FOXO3/CDKN2A/KRAS/RASSF1/ALK	4.2694964105659
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	18/1500	46/9376	2.44591304347826	PSME4/PSMA7/SEM1/PSMB1/PSMA1/POMP/PSMD8/PSMD7/PSMA3/PSMA5/PSMB7/PSMB2/PSMC5/PSMD4/PSMA4/IFNG/PSMB6/PSMD1	4.29001374299438
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1500	105/9376	1.90496507936508	TOMM7/RPS27A/ARIH1/USP15/MAPK8/UBA52/AMBRA1/TAX1BP1/MARCHF5/HUWE1/RAB7A/TBC1D15/PRKN/TOMM20/OPTN/EIF2AK3/GABARAPL2/OPA1/CSNK2A1/RRAS2/FIS1/TBK1/HIF1A/BNIP3L/SMURF2/SMURF1/FOXO3/PHB2/BCL2L1/RAB5A/KRAS/CALCOCO2	4.06950507146146
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	23/1500	67/9376	2.14575124378109	CAMK4/RAP1B/RAP1A/BRAF/CALM1/GNAQ/PRKCB/PPP3CC/RPS6KA3/PLCB1/PPP1CA/PPP3CA/CAMK2D/PRKCA/PRKACB/CREBBP/ITPR1/PPP3CB/PPP1CB/MAPK1/RAF1/MAP2K1/KRAS	4.10728309382794
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	30/1500	98/9376	1.9134693877551	INPP4B/CALM1/INPP4A/PIP4K2A/PRKCB/PLCB1/PI4KA/PIK3R1/ITPKB/PRKCA/MTMR3/ITPR1/INPP5A/PI4K2B/BPNT2/SYNJ1/PIK3C3/SACM1L/PIK3CD/CDS2/IP6K2/PIK3CB/MTMR6/MTMR1/PIK3C2A/MTMR8/PIKFYVE/MTM1/IP6K1/IPMK	3.96696405741835
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	34/1500	117/9376	1.81643304843305	H2AZ2/H2AZ1/MACROH2A1/H2AC20/H2AJ/BICRAL/ACTG1/ARID2/ACTB/ARID1B/MORF4L1/SMARCC1/EPC1/PBRM1/RSF1/EPC2/BRD9/BRD7/INO80/MBD2/H2AC17/ACTR6/H2AC6/MTA3/HDAC1/UCHL5/GATAD2A/BCL7C/TRRAP/ACTL6A/ZNHIT1/RBBP7/SS18/MEAF6	3.8780185223836
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	32/1500	109/9376	1.83505810397554	CD3G/CD3D/CD247/RUNX1/CD3E/PRKCQ/STAT1/IL21R/MAPK8/NFATC2/PPP3CC/STAT5B/JAK1/PPP3CA/LCK/TGFBR2/RORA/TGFB1/NFKB1/PPP3CB/NFATC3/MAPK1/JAK3/LAT/IL2RB/HIF1A/IFNGR1/MAPK14/IL4R/IFNG/SMAD2/JAK2	3.82682653371299
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	25/1500	78/9376	2.0034188034188	ELMO1/SEPTIN6/ARPC3/ARPC2/ARPC5/ACTG1/ACTB/ACTR3/PIK3R1/RAC1/PXN/CD2AP/DNM2/HCLS1/WASF2/ARHGAP10/PIK3CD/ELMO2/SEPTIN9/PIK3CB/ARPC4/ITGB1/ARPC5L/CLTB/VCL	3.88340941850883
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	27/1500	87/9376	1.93986206896552	BCL2/MAPK8/BRAF/SOS1/RAC2/PIK3R1/TGFBR2/RAC1/AREG/TGFB1/SOS2/GSK3B/LEF1/MAPK1/RAF1/MAP2K1/TCF7/PIK3CD/RALA/PIK3CB/CYCS/BAX/SMAD2/RPS6KB1/GADD45A/APPL1/KRAS	3.84341854665771
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	50/1500	196/9376	1.59455782312925	RPS27A/PIK3R5/GNG2/STAT1/MAPK8/MAP2K4/NFATC2/UBA52/CALM1/TRAF3/GNB1/PPP3CC/CDK6/JAK1/PIK3R1/PPP3CA/CXCL8/RB1/RAC1/CLEC2B/GNG5/CREB1/GNB5/NFKB1/GSK3B/CREBBP/ITPR1/PPP3CB/NFATC3/EIF2AK2/LEF1/MAPK1/RAF1/MAP2K1/TCF7/CASP8/ANGPT2/PIK3C3/PIK3CD/TBK1/ATG14/HIF1A/PIK3CB/CYCS/IFNGR1/MAPK14/BAX/TRADD/KRAS/JAK2	3.67095623555699
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	49/1500	193/9376	1.58695682210708	PIK3R5/GNG2/ELMO1/STAT1/RAP1B/GRK5/ITK/RAP1A/BRAF/CXCR4/GNAQ/GNB1/PRKCB/SOS1/VAV1/STAT5B/DOCK2/PLCB1/RAC2/PIK3R1/CXCL8/CX3CR1/RAC1/PRKACB/XCL2/GNG5/VAV3/SOS2/GNB5/NFKB1/GSK3B/PXN/CXCL14/CCR9/MAPK1/RAF1/XCL1/MAP2K1/PIK3CD/JAK3/TIAM1/PIK3CB/GRK6/FOXO3/CCL28/KRAS/RASGRP2/JAK2/PRKCZ	3.5955963514265
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	29/1500	98/9376	1.84968707482993	ASAP1/ARPC3/ARPC2/ARPC5/CFL1/PRKCB/VAV1/ACTR3/PRKCE/RAC2/PIK3R1/PRKCA/RAC1/VAV3/GAB2/MAPK1/DNM2/RAF1/MAP2K1/WASF2/PIK3CD/LAT/PIK3CB/ARPC4/BIN1/RPS6KB1/PLA2G6/ARPC5L/GSN	3.68997377589948
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	26/1500	86/9376	1.88973643410853	CBLB/MAPK8/MAP2K4/BRAF/PRKCB/SOS1/STAT5B/PIK3R1/CAMK2D/PAK2/PRKCA/AREG/SOS2/GSK3B/MAPK1/RAF1/CDKN1B/MAP2K1/PIK3CD/NCK1/NCK2/PIK3CB/RPS6KB1/KRAS/ABL2/ABL1	3.61727192460618
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	23/1500	73/9376	1.96938812785388	CXCR4/MLLT3/RANBP2/KAT2B/SAMHD1/VPS4B/CREBBP/CPSF6/NUP153/BST2/CCNT1/PSIP1/MX2/MDFIC/PIN1/TSG101/PDCD6IP/APOBEC3H/APOBEC3C/TRIM5/CCNT2/APOBEC3G/TNPO3	3.62849083257606
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	24/1500	78/9376	1.92328205128205	INPP4B/INPP4A/PIP4K2A/PLCB1/PI4KA/ITPKB/MTMR3/INPP5A/PI4K2B/SYNJ1/PIK3C3/SACM1L/PIK3CD/IP6K2/INPP5K/PIK3CB/MTMR6/MTMR1/PIK3C2A/MTMR8/PIKFYVE/MTM1/IP6K1/IPMK	3.57326592014478
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	16/1500	44/9376	2.2729696969697	MGAT4A/TMEM258/DAD1/MAN2A1/B4GALT1/MAN1C1/MAN1A1/ALG13/FUT8/OSTC/KRTCAP2/MAGT1/DDOST/MAN1A2/RPN2/STT3B	3.6934774562591
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	57/1500	238/9376	1.49700840336134	GNG2/RASA2/RAP1B/PLAAT2/MAPK8/RAP1A/CALM1/RASGRP1/GNB1/PRKCB/ETS1/SOS1/RASA1/RAC2/PIK3R1/STK4/PAK2/IGF1R/PRKCA/RAC1/PRKACB/GNG5/EXOC2/SOS2/GNB5/NFKB1/RALGAPA2/RASGRF2/PDGFD/GAB2/MAPK1/RAF1/MAP2K1/RRAS2/ANGPT2/SHOC2/PIK3CD/TIAM1/RALA/LAT/TBK1/PIK3CB/RALGAPB/NF1/RASAL3/EFNA5/FASLG/PLA2G6/RASSF5/BCL2L1/RAB5A/KRAS/RASSF1/RASGRP2/ABL2/ABL1/PTPN11	3.38926125919188
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	50/1500	205/9376	1.52455284552846	CD3G/CD3D/CD247/CD3E/STAT1/BCL2/MAPK8/MAP2K4/TRAF3/CCND3/CDK6/PDIA3/RELB/SEM1/TNFAIP3/JAK1/PIK3R1/NEDD4/RB1/RAC1/CIR1/NFKB1/PSMD8/ITGAL/CD44/PSMD7/EIF2AK2/CDKN1B/TAB2/CASP8/PIK3CD/JAK3/PSMC5/TBK1/PSMD4/PIK3CB/CYCS/MAPK14/HDAC1/BAX/RIPK1/GADD45A/MAP3K14/CD58/SNW1/NCOR2/VIM/TRADD/PSMD1/RUNX3	3.31387593363514
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1500	80/9376	1.8752	BCL2/BRAF/PRKCB/SOS1/JAK1/PIK3R1/IGF1R/PRKCA/SOS2/GSK3B/PDGFD/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/NF1/BAX/RPS6KB1/FOXO3/BCL2L1/KRAS/EIF4E2/JAK2	3.43069933984056
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	33/1500	122/9376	1.69075409836066	STAT1/NCOA1/NCOA2/PRKCB/ACTG1/MED13L/FOXO1/ACTB/MED4/PLCB1/NCOR1/PIK3R1/KAT2B/NCOA3/PRKCA/PRKACB/MED30/GSK3B/CREBBP/MED14/MED27/MAPK1/RAF1/MAP2K1/PIK3CD/ATP1B3/HIF1A/PIK3CB/HDAC1/KRAS/ESR1/ATP2A3/RHEB	3.35132890328784
NA	NA	hsa04517	IgSF CAM signaling	68/1500	299/9376	1.42155629877369	FYN/MYL12A/CD96/PRKCQ/RAP1B/MAPK8/MYL12B/RAP1A/ARPC3/ARPC2/ARPC5/CASK/GRIP1/MBP/CD48/MYL6/PRKCB/RAPGEF2/ACTG1/VAV1/ITGA4/FOXO1/ACTB/ACTR3/RASA1/CD2/PIK3R1/PAK2/LCK/PRKCA/RAC1/MSN/MYH9/ERC1/VAV3/GSK3B/SLAMF7/PXN/ITGAL/NLGN4X/CD2AP/MAPK1/PALS2/MAP2K1/CRTAM/PIK3CD/NCK1/NCK2/NCAM1/TIGIT/PIK3CB/ROBO1/ARPC4/MAPK14/CD226/SH2D1B/ITGB1/MYL9/PLXNA4/ARPC5L/CD244/SH2D1A/SLIT2/SLAMF6/ABL1/PTPN11/VCL/PRKCI	3.23294579593097
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	30/1500	108/9376	1.7362962962963	NUP98/XPO4/SUMO2/RANBP2/MAGOH/SRRM1/XPO6/SEC13/NUP133/NUP153/SUMO1/NUP214/KPNA6/SENP2/NUP54/KPNA1/CSE1L/NUP88/THOC1/THOC7/NUP210/IPO9/UPF3A/THOC2/TNPO1/NCBP1/KPNA5/NUP58/KPNA3/TNPO3	3.35853512797866
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	41/1500	163/9376	1.57225357873211	STAT4/STAT1/BCL2/MAPK8/MAP2K4/NFATC2/BRAF/TRAF3/PRKCB/SOS1/STAT5B/JAK1/YWHAB/PIK3R1/CXCL8/RB1/TGFBR2/PRKCA/TGFB1/YWHAZ/SOS2/CREB1/NFKB1/CREBBP/NFATC3/MAPK1/RAF1/MAP2K1/TAB2/CASP8/PIK3CD/JAK3/TBK1/PIK3CB/CYCS/MAPK14/BAX/FASLG/KRAS/ATF2/JAK2	3.21632701062668
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1500	101/9376	1.73285808580858	STAT1/BCL2/MAPK8/PRKCB/FOXO1/STAT5B/PRKCE/PLCB1/PIK3R1/CXCL8/TGFBR2/PRKCA/RAC1/TGFB1/NFKB1/MAPK1/DIAPH1/CDKN1B/PIK3CD/COL3A1/PIK3CB/MAPK14/BAX/SMAD2/KRAS/JAK2/PRKCZ/VCAM1	3.23148411673782
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	21/1500	69/9376	1.9023768115942	FYN/MAPK8/MAP2K4/SOS1/VAV1/RAC2/PIK3R1/PRKCA/RAC1/ALOX5AP/VAV3/SOS2/GAB2/MAPK1/RAF1/MAP2K1/PIK3CD/LAT/PIK3CB/MAPK14/KRAS	3.2831144993501
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	48/1500	200/9376	1.50016	FYN/MAPK8/CYTH1/ARPC3/ARPC2/ARPC5/RAB1A/CYFIP2/ACTG1/ACTB/ACTR3/WIPF1/SEC24B/PAK2/CXCL8/BRK1/RAC1/ABI1/MYH9/TMED10/NFKB1/MYO1F/MYO1D/MAPK1/HCLS1/TAB2/CASP8/WASF2/MYO5A/GNA13/NCK1/NCK2/F2R/CYCS/ARPC4/MAPK14/ARF1/BAX/RIPK1/ITGB1/FASLG/ARPC5L/TRADD/SEC24C/WIPF2/ABL1/PTPN11/CASP4	3.12015138415042
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	48/1500	203/9376	1.47799014778325	FYN/MYL12A/RAP1B/BCL2/MAPK8/MYL12B/RAP1A/BRAF/PRKCB/CCND3/SOS1/ACTG1/VAV1/ITGA4/ACTB/PPP1CA/RAC2/PIK3R1/RAPGEF1/PAK2/IGF1R/PRKCA/RAC1/PPP1R12A/VAV3/SOS2/GSK3B/PDGFD/PXN/PPP1CB/MAPK1/DIAPH1/RAF1/MAP2K1/THBS1/PPP1R12B/PIK3CD/CAPN2/PIK3CB/ARHGAP35/ITGB1/MYL9/MYL11/COL6A2/XIAP/VCL/LAMB3/ITGB7	3.00462088255221
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	35/1500	138/9376	1.58531400966184	PPP2R5C/CALM1/ANAPC16/PPP3CC/RPS6KA3/FBXW11/SPDYE2/PPP1CA/YWHAB/PPP3CA/CAMK2D/IGF1R/RBX1/PRKACB/BTRC/YWHAZ/PPP2R5A/CDC27/ITPR1/PPP3CB/CUL1/SPDYE18/SMC1B/SPDYE1/PPP1CB/MAPK1/ANAPC11/MAP2K1/PPP2R5E/SMC3/MAPK14/SPDYA/SPDYE21/CDC16/CPEB3	3.02285905066498
Human Diseases	Cancer: specific types	hsa05214	Glioma	22/1500	76/9376	1.80940350877193	CAMK4/CAMK1D/BRAF/CALM1/PRKCB/SOS1/CDK6/PIK3R1/CAMK2D/IGF1R/RB1/PRKCA/SOS2/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/BAX/GADD45A/CDKN2A/KRAS	3.09178167358266
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	44/1500	184/9376	1.49472463768116	SSH2/FYN/ABLIM1/MYL12A/MYL12B/NFATC2/CXCR4/CFL1/PPP3CC/RASA1/RAC2/PIK3R1/PPP3CA/CAMK2D/PAK2/PRKCA/RAC1/SEMA4D/GSK3B/PPP3CB/NFATC3/MAPK1/RAF1/PIK3CD/NCK1/NCK2/BMPR2/PIK3CB/EPHA4/ROBO1/NEO1/ITGB1/MYL9/EFNA5/PLXNA4/WNT5A/RGS3/KRAS/SLIT2/ABL1/PLXNC1/PTPN11/RYK/PRKCZ	2.95764371593819
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	48/1500	205/9376	1.46357073170732	H4C3/RASA2/TRAF3/CCND3/HDAC4/CDK6/STAT5B/DLG1/SP100/JAK1/YWHAB/PIK3R1/KAT2B/RB1/RAC1/PRKACB/UBR4/SND1/GTF2A2/YWHAZ/CREB1/NFKB1/CREBBP/UBE3A/PXN/POLB/EIF2AK2/MAPK1/GTF2E2/CDKN1B/RBL1/CASP8/PIK3CD/JAK3/RBL2/TRAF1/H4C5/PIK3CB/HDAC1/BAX/VAC14/H2BC12/SNW1/TRADD/CDKN2A/KRAS/ATF2/GSN	2.92861987965171
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	25/1500	91/9376	1.71721611721612	IFITM1/CARD11/NFATC2/PRKCB/PPP3CC/SOS1/VAV1/RAC2/PIK3R1/PPP3CA/MALT1/RAC1/VAV3/SOS2/NFKB1/GSK3B/PPP3CB/NFATC3/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3AP1/PIK3CB/KRAS	3.00025519593348
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	41/1500	170/9376	1.5075137254902	RUNX1/MYL12A/MAPK8/ARHGEF18/MYL12B/RAP1A/RAB8B/ARPC3/ARPC2/ARPC5/PPP2R2B/MYL6/RAPGEF2/MAP3K5/ACTG1/ACTB/ACTR3/PRKCE/DLG1/NEDD4/RAC1/MSN/PRKACB/MYH9/PPP2R2D/PATJ/HCLS1/RAB8A/TIAM1/PRKAA1/ARPC4/PPP2R2A/SYMPK/ITGB1/MYL9/PALS1/ARPC5L/CACNA1D/DLG3/PRKCI/PRKCZ	2.91417200251995
Organismal Systems	Immune system	hsa04611	Platelet activation	32/1500	126/9376	1.5874708994709	FYN/PIK3R5/MYL12A/APBB1IP/RAP1B/MYL12B/RAP1A/RASGRP1/GNAQ/ACTG1/STIM1/ACTB/PLCB1/PPP1CA/PIK3R1/PRKACB/PPP1R12A/ITPR1/PPP1CB/MAPK1/PIK3CD/TBXAS1/GNA13/F2R/COL3A1/PIK3CB/MAPK14/ARHGAP35/ITGB1/RASGRP2/PRKCI/PRKCZ	2.897204684667
Human Diseases	Infectious disease: viral	hsa05162	Measles	34/1500	136/9376	1.56266666666667	CD3G/CD3D/CBLB/CD3E/STAT1/BCL2/MAPK8/TRAF3/CCND3/CDK6/STAT5B/TNFAIP3/JAK1/PIK3R1/EIF3H/MSN/NFKB1/GSK3B/EIF2AK2/CSNK2A1/CDKN1B/TAB2/MX2/CASP8/PIK3CD/JAK3/TBK1/IL2RB/PIK3CB/CYCS/BAX/FASLG/TRADD/BCL2L1	2.88445036517972
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	22/1500	78/9376	1.76300854700855	CNOT6L/PAN3/ZCCHC7/XRN1/C1D/DDX6/LSM6/LSM7/CNOT2/TENT4B/CNOT1/EXOSC7/DCP1A/MTREX/XRN2/LSM3/LSM8/LSM5/CNOT10/LSM4/EXOSC9/CNOT4	2.9529789234167
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	18/1500	60/9376	1.8752	NFATC2/PRKCB/PPP3CC/RAC2/PIK3R1/PPP3CA/PRKCA/RAC1/PXN/PPP3CB/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/MAPK14/SH2D2A/KRAS	2.96788185242823
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/1500	34/9376	2.20611764705882	POLR1F/POLR2L/POLR2G/POLR3GL/POLR2B/POLR2K/POLR2I/POLR1C/POLR2F/POLR3C/POLR2J/POLR3B	3.07459284962999
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	47/1500	204/9376	1.4401045751634	LUM/DCN/BRAF/PRKCB/SOS1/ACTG1/VAV1/ACTB/PPP1CA/PIK3R1/CAMK2D/IGF1R/PDCD4/PRKCA/RAC1/MSN/PRKACB/TGFB1/PPP1R12A/VAV3/SOS2/PXN/ITPR1/CD44/PPP1CB/MAPK1/RAF1/HCLS1/MAP2K1/THBS1/RRAS2/PPP1R12B/FRS2/PIK3CD/TIAM1/HIF1A/PIK3CB/MAPK14/ITGB1/SMAD2/RPS6KB1/PLAUR/FASLG/WNT5A/KRAS/ESR1/PTPN11	2.77343095186411
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	27/1500	103/9376	1.63852427184466	PPP2R5C/PPP2R2B/RNGTT/MSI2/WDR33/PPP1CA/RNMT/PPP2R2D/SMG6/PPP2R5A/CPSF6/MAGOH/SRRM1/PPP2R3A/PPP1CB/PPP2R3C/PPP2R5E/HBS1L/UPF3A/GSPT1/SSU72/PPP2R2A/SYMPK/PAPOLG/NCBP1/SMG5/SMG7	2.84357250919384
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	21/1500	75/9376	1.75018666666667	BCL2/MAP3K5/PIK3R1/REV3L/GSTP1/MAPK1/CASP8/MGST3/PIK3CD/PIK3CB/CYCS/BRCA1/BAX/FASLG/XPA/XIAP/CDKN2A/BCL2L1/POLH/SLC31A1/MGST1	2.84651557549933
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	36/1500	149/9376	1.51022818791946	GNG2/NDUFA4/MAPK8/NDUFB2/NDUFB1/GNAQ/GNB1/PRKCB/NDUFA1/PLCB1/PRKCA/NDUFB7/PRKACB/NDUFS6/GNG5/GNB5/NDUFAB1/NDUFC1/NDUFA2/NDUFA5/NDUFA12/ITPR1/NDUFB4/NDUFV2/NDUFS5/MAPK1/NDUFB11/MAPK14/NDUFV1/NDUFB5/NDUFB3/NDUFB6/NDUFS4/NDUFB9/CACNA1D/NDUFS7	2.73971719681508
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	51/1500	227/9376	1.40433480176211	GNG2/NFATC2/CALM1/CXCR4/GNAQ/GNB1/PRKCB/PPP3CC/SOS1/CDK6/PDIA3/PLCB1/JAK1/RAC2/PIK3R1/PPP3CA/CXCL8/RB1/AKAP13/PRKCA/RAC1/PRKACB/GNG5/SOS2/CREB1/GNB5/NFKB1/GSK3B/PXN/ITPR1/PPP3CB/NFATC3/MAPK1/RAF1/MAP2K1/CASP8/PIK3CD/GNA13/TBK1/PIK3CB/CYCS/MAPK14/BAX/RIPK1/RPS6KB1/FASLG/TRADD/CDKN2A/KRAS/ATF2/RHEB	2.69119800502718
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1500	71/9376	1.76075117370892	STAT1/MAPK8/ESR2/SOS1/STAT5B/PIK3R1/SOS2/NFKB1/GSK3B/PRL/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/MAPK14/FOXO3/KRAS/ESR1/JAK2	2.80796720142879
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1500	63/9376	1.78590476190476	POLR2L/CCNH/RBX1/MNAT1/POLR2G/POLR2B/POLR2K/RFC1/RPA3/RAD23B/POLR2I/CUL4A/XPC/POLR2F/XPA/POLR2J/RAD23A/POLE4	2.73132768933612
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	23/1500	87/9376	1.65247509578544	COX7C/UQCRB/COX7A2/COX6C/COX6B1/UQCR10/COX4I1/UQCR11/COX7B/COX7A2L/COX5B/UQCRFS1/UQCRQ/UQCRH/COX6A1/CACNB2/TPM4/ATP1B3/COX7A1/COX5A/CACNA1D/ATP2A3/UQCRHL	2.66819458639737
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	33/1500	137/9376	1.50563503649635	CTSW/BCL2/GZMB/MAPK8/MAP3K5/ACTG1/PRF1/ACTB/PIK3R1/NFKB1/ITPR1/PARP4/CTSS/EIF2AK3/MAPK1/RAF1/MAP2K1/CASP8/PIK3CD/TRAF1/CAPN2/PIK3CB/CYCS/IL3RA/BAX/RIPK1/GADD45A/FASLG/MAP3K14/TRADD/XIAP/BCL2L1/KRAS	2.60173688186695
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1500	138/9376	1.49472463768116	CBLB/PDE3B/MAPK8/BRAF/CALM1/SOS1/FOXO1/RPTOR/PPP1CA/PIK3R1/RAPGEF1/PRKACB/SOS2/GSK3B/INPP5A/PHKB/PRKAR2A/PTPN1/PPP1CB/MAPK1/RAF1/MAP2K1/PIK3CD/PRKAA1/PIK3CB/RPS6KB1/PRKAR1B/KRAS/RHEB/EIF4E2/PRKCI/PRKCZ/G6PC3	2.55500948877929
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1500	133/9376	1.50391979949875	GNG2/MAPK8/PPP2R5C/CALM1/GNAQ/PPP2R2B/GNB1/PRKCB/PPP3CC/PLCB1/SLC18A2/PPP1CA/PPP3CA/CAMK2D/PRKCA/PRKACB/PPP2R2D/GNG5/CREB1/GNB5/PPP2R5A/GSK3B/ITPR1/PPP2R3A/PPP3CB/PPP1CB/PPP2R3C/PPP2R5E/MAPK14/PPP2R2A/CACNA1D/ATF2	2.55422517159075
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	39/1500	170/9376	1.43397647058824	BRAF/PRKCB/SOS1/ACTG1/CDK6/ARID2/ACTB/ARID1B/PIK3R1/IGF1R/RB1/TGFBR2/PRKCA/SMARCC1/TGFB1/SOS2/GSK3B/GSTP1/PBRM1/NFE2L2/LEF1/MAPK1/RAF1/BRD7/MAP2K1/TCF7/MGST3/PIK3CD/PIK3CB/BAX/SMAD2/RPS6KB1/GADD45A/ACTL6A/WNT5A/CDKN2A/BCL2L1/KRAS/MGST1	2.49191700011489
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	63/1500	300/9376	1.31264	RASA2/RAP1B/MAPK8/MAP2K4/RAP1A/BRAF/RPS6KA5/RASGRP1/PRKCB/RAPGEF2/PPP3CC/SOS1/MAP3K5/RPS6KA3/RELB/RASA1/TAOK3/MAP3K2/RAC2/PPP3CA/STK4/PAK2/IGF1R/TGFBR2/PRKCA/RAC1/AREG/PRKACB/TGFB1/SOS2/NFKB1/RASGRF2/NLK/PDGFD/MAP4K3/PPP3CB/NFATC3/MAP4K4/MAP2K5/MAPK1/RAF1/CACNB2/MAP2K1/RRAS2/TAB2/ANGPT2/MAX/MAP3K8/MAPK14/MAP3K3/NF1/EFNA5/MAPK8IP3/GADD45A/FASLG/MAP3K14/MECOM/TRADD/CACNA1D/KRAS/ATF2/RASGRP2/MAP3K9	2.4017972309448
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	42/1500	187/9376	1.40389304812834	STAT1/BCL2/MAPK8/CYBA/TRAF3/NEK7/TNFAIP3/PLCB1/JAK1/TANK/CXCL8/ATG5/MCU/NFKB1/TXN/CARD16/NLRP1/ANTXR2/ITPR1/ERBIN/GABARAPL2/CARD8/MAPK1/PKN2/GBP5/GBP4/TAB2/CASP8/VDAC1/TBK1/NOD1/MAPK14/RIPK1/XIAP/SUGT1/BCL2L1/VDAC2/RBCK1/CASP4/DEFA3/TP53BP1/GBP1	2.43462159340083
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	23/1500	90/9376	1.59739259259259	CAMK4/FOXO1/RPTOR/PIK3R1/IGF1R/PRKACB/ATG5/CREB1/NFKB1/EHMT1/ATG13/PIK3CD/PRKAA1/PIK3CB/BAX/RB1CC1/RPS6KB1/APPL1/FOXO3/KRAS/ATF2/RHEB/EIF4E2	2.48510739836678
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	39/1500	173/9376	1.4091098265896	RAB11A/STAT1/NUP98/TRAF3/PRKCB/CCND3/ACTG1/CDK6/ACTB/JAK1/PIK3R1/CXCL8/PRKCA/NFKB1/CREBBP/EIF2AK2/KPNA6/MAPK1/RAF1/MAP2K1/KPNA1/MX2/CASP8/DNAJC3/PIK3CD/VDAC1/HNRNPUL1/TBK1/PIK3CB/CYCS/IFNGR1/BAX/IFNG/FASLG/TRADD/KPNA5/CALCOCO2/FDPS/JAK2	2.370154549067
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	10/1500	30/9376	2.08355555555556	OGDH/SUCLG2/SUCLA2/ACO2/SDHB/MDH1/MDH2/IDH2/DLD/DLST	2.59404398743883
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1500	212/9376	1.35627672955975	SKAP1/APBB1IP/RAP1B/SIPA1L1/EVL/RAP1A/BRAF/CALM1/GNAQ/PRKCB/RAPGEF2/ACTG1/VAV1/PFN1/ACTB/PLCB1/RAC2/PIK3R1/RAPGEF1/IGF1R/PRKCA/RAC1/VAV3/PDGFD/SIPA1L3/ITGAL/MAPK1/RAF1/MAP2K1/THBS1/ANGPT2/PIK3CD/TIAM1/RALA/LAT/F2R/PIK3CB/MAPK14/ITGB1/EFNA5/RASSF5/KRAS/RASGRP2/PRKCI/PRKCZ/MAGI3	2.28976683765277
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	68/1500	333/9376	1.27641241241241	MAML2/STAT1/PPP2R5C/ATP6V1G1/TRAF3/PPP2R2B/CCND3/SOS1/ATP6V0E1/CDK6/ITGA4/FOXO1/DLG1/JAK1/PIK3R1/RB1/PRKACB/UBR4/PPP2R2D/SOS2/CREB1/PSEN1/PPP2R5A/NFKB1/GSK3B/CREBBP/UBE3A/PXN/PATJ/PPP2R3A/EIF2AK2/PPP2R3C/MAPK1/RAF1/CDKN1B/ATR/MAML3/RBL1/MAP2K1/THBS1/TCF7/PPP2R5E/MX2/CASP8/PIK3CD/RBL2/NFX1/TBK1/PIK3CB/HDAC1/BAX/ATP6V1E1/PPP2R2A/ITGB1/RPS6KB1/ATP6V1H/PALS1/FASLG/COL6A2/TRADD/WNT5A/DLG3/KRAS/RHEB/LAMB3/PRKCI/PRKCZ/ITGB7	2.24130936947342
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	25/1500	103/9376	1.51715210355987	CD3G/CD3D/CD247/CD3E/MAPK8/MAP2K4/GNAQ/PPP2R2B/PLCB1/PIK3R1/CXCL8/TGFBR2/PPP2R2D/TGFB1/NFKB1/MAPK1/CASP8/PIK3CD/PIK3CB/IFNGR1/MAPK14/IFNG/PPP2R2A/SMAD2/FASLG	2.30305967932316
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	16/1500	59/9376	1.69509604519774	BRAF/SOS1/PIK3R1/SOS2/GSK3B/LEF1/MAPK1/RAF1/MAP2K1/TCF7/PIK3CD/PIK3CB/BAX/GADD45A/FOXO3/KRAS	2.33728240452966
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	24/1500	99/9376	1.51531313131313	BCL2/MAPK8/BRAF/ESR2/SOS1/NCOR1/PIK3R1/IGF1R/NCOA3/RB1/PRKACB/SOS2/MAPK1/RAF1/CDKN1B/MAP2K1/PIK3CD/PIK3CB/MAPK14/BAX/RPS6KB1/CDKN2A/KRAS/ESR1	2.24938317503725
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	26/1500	110/9376	1.4774303030303	BCL2/ELOB/PRKCB/PIK3R1/CAMK2D/IGF1R/RBX1/PRKCA/CUL2/NFKB1/CREBBP/MAPK1/CDKN1B/MAP2K1/ANGPT2/PIK3CD/PGK1/HIF1A/PIK3CB/IFNGR1/ELOC/PDK1/IFNG/RPS6KB1/EIF4E2/VHL	2.1980551728143
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	12/1500	41/9376	1.82946341463415	BRAF/RPS6KA5/CXCL8/RB1/MAPK1/RAF1/MAP2K1/THBS1/DAPK2/CDKN2A/KRAS/RASSF1	2.32279250732271
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	32/1500	142/9376	1.40860093896714	BCL2/MAPK8/MAP2K4/CYBA/CALM1/MAP3K5/ACTG1/ACTB/SUMO2/RAC2/KLF2/PIK3R1/RAC1/NFKB1/TXN/GSTP1/NFE2L2/MAP2K5/SUMO1/MGST3/PIK3CD/ACVR2A/BMPR2/PRKAA1/PIK3CB/PECAM1/MAPK14/IFNG/PLAT/MGST1/PRKCZ/VCAM1	2.14105099527485
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1500	158/9376	1.38464135021097	BRAF/ATP6V1G1/PRKCB/SOS1/RPS6KA3/RPTOR/PIK3R1/IGF1R/LAMTOR4/PRKCA/SOS2/GSK3B/MAPKAP1/RICTOR/SEC13/SLC38A9/MAPK1/RAF1/LAMTOR1/LAMTOR5/MAP2K1/PIK3CD/PRKAA1/PIK3CB/ATP6V1E1/RPS6KB1/ATP6V1H/FNIP2/SLC7A5/WNT5A/CAB39/KRAS/RHEB/EIF4E2/WDR59	2.12786747382149
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	72/1500	362/9376	1.24322651933702	PIK3R5/GNG2/BCL2/PPP2R5C/PPP2R2B/GNB1/CCND3/SOS1/CDK6/ITGA4/RPTOR/JAK1/YWHAB/PIK3R1/IGF1R/PRKCA/RAC1/AREG/PPP2R2D/YWHAZ/GNG5/SOS2/CREB1/GNB5/PPP2R5A/NFKB1/GSK3B/PDGFD/PPP2R3A/PRL/PPP2R3C/MAPK1/PKN2/C8orf44-SGK3/RAF1/CDKN1B/MAP2K1/THBS1/PPP2R5E/ANGPT2/PIK3CD/JAK3/RBL2/PIK3AP1/PRKAA1/F2R/IL2RB/PIK3CB/MTCP1/IL3RA/BRCA1/IL4R/PPP2R2A/OSM/ITGB1/EFNA5/RPS6KB1/FASLG/COL6A2/FOXO3/PHLPP1/BCL2L1/KRAS/ATF2/CSHL1/RHEB/EIF4E2/JAK2/LAMB3/G6PC3/IL7/ITGB7	2.05960931492109
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/1500	106/9376	1.47421383647799	ZEB1/BCL2/BRAF/SOS1/FOXO1/PIK3R1/IGF1R/RB1/SOS2/CREB1/NFKB1/GSK3B/PDGFD/CREBBP/GSTP1/LEF1/MAPK1/RAF1/CDKN1B/MAP2K1/TCF7/PIK3CD/PIK3CB/KRAS/PLAT	2.14272137060393
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	34/1500	156/9376	1.36232478632479	PIAS1/STAT1/BRAF/TRAF3/PPP2R2B/SOS1/CDK6/JAK1/YWHAB/PIK3R1/EIF3E/RB1/PPP2R2D/YWHAZ/SOS2/NFKB1/GSK3B/EIF2AK2/MAPK1/RAF1/MAP2K1/MX2/CASP8/PIK3CD/TBK1/PIK3CB/CYCS/BAX/IFNG/PPP2R2A/RIPK1/FASLG/TRADD/KRAS	1.99146783989966
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1500	34/9376	1.83843137254902	CRY1/FBXW11/RBX1/RORA/BTRC/CREB1/CUL1/NR1D2/PRKAA1/BHLHE40	2.13729988051402
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1500	83/9376	1.50618473895582	JARID2/SFMBT2/MBD5/FOXK2/UBE2D2/PHC3/SCMH1/KDM2B/OGT/CREBBP/LCOR/PCGF5/ASXL2/MAX/AUTS2/HDAC1/SUZ12/L3MBTL4/RBBP7/EZH1	2.02138267459526
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	16/1500	63/9376	1.5874708994709	SMYD3/CAMKMT/KMT2C/PHYKPL/ASH1L/SETD2/EHMT1/ACAT1/SMYD2/KMT5B/DLD/MECOM/TMLHE/DLST/NSD1/EZH1	2.04169208812926
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	23/1500	99/9376	1.45217508417508	GPCPD1/MAPK8/PRKCB/SOS1/RAC2/PIK3R1/PRKCA/RAC1/SOS2/CHKA/PDGFD/CHPT1/MAPK1/RAF1/MAP2K1/SLC44A2/WASF2/PIK3CD/HIF1A/PIK3CB/RPS6KB1/KRAS/RHEB	1.97378053208668
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/1500	44/9376	1.70472727272727	CCNH/TAF3/TAF4B/GTF2A2/MNAT1/GTF2F2/TAF2/TAF11/GTF2E2/TAF10/TAF12/TAF1	2.04474175687397
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	25/1500	110/9376	1.42060606060606	PDE3B/MAPK8/BRAF/ANAPC16/RPS6KA3/SPDYE2/PIK3R1/IGF1R/STK10/PRKACB/CDC27/SPDYE18/SPDYE1/MAPK1/ANAPC11/RAF1/MAP2K1/PIK3CD/PIK3CB/MAPK14/SPDYA/SPDYE21/CDC16/KRAS/CPEB3	1.93644040054474
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	24/1500	105/9376	1.42872380952381	PRKCQ/BCL2/CARD11/TRAF3/PRKCB/RELB/TNFAIP3/LCK/CXCL8/MALT1/ERC1/NFKB1/CSNK2A1/TAB2/TRAF1/LAT/RIPK1/EDARADD/GADD45A/MAP3K14/TRADD/XIAP/BCL2L1/VCAM1	1.92791275254233
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	24/1500	105/9376	1.42872380952381	CBLB/STAT1/MAPK8/NFATC2/CALM1/PPP3CC/RELB/PIK3R1/PPP3CA/MALT1/NFKB1/ITPR1/PPP3CB/NFATC3/MAPK1/RAF1/RRAS2/CASP8/PIK3CD/PIK3CB/MAPK14/MAP3K14/KRAS/PTPN11	1.92791275254233
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	20/1500	85/9376	1.47074509803922	ADSS2/ADK/NT5C2/APRT/RRM1/GUK1/ASMTL/AK5/NME7/DGUOK/ADA2/HPRT1/HDDC2/NME3/NT5C3A/CMPK1/NT5E/CDA/GMPS/CTPS1	1.90257792356197
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	27/1500	122/9376	1.38334426229508	STAT1/MAPK8/MAP2K4/GNAQ/PRKCB/SOS1/STAT5B/PLCB1/PIK3R1/PRKCA/PRKACB/SOS2/CREB1/GSK3B/CREBBP/ITPR1/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/MAPK14/CACNA1D/KRAS/ATF2/CSHL1/JAK2	1.8598698280445
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1500	133/9376	1.36292731829574	MAPK8/BRAF/SOS1/FOXO1/KLF2/PIK3R1/STK4/IGF1R/TGFBR2/TGFB1/SOS2/NLK/CREBBP/GABARAPL2/MAPK1/C8orf44-SGK3/RAF1/CDKN1B/MAP2K1/PIK3CD/RBL2/PRKAA1/PIK3CB/MAPK14/GADD45A/FASLG/FOXO3/KRAS/G6PC3	1.83957465606828
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/1500	119/9376	1.3656918767507	MAPK8/MAP2K4/RPS6KA5/TRAF3/MAP3K5/TNFAIP3/PIK3R1/CREB1/NFKB1/MAPK1/MAP2K1/TAB2/CASP8/PIK3CD/TRAF1/PIK3CB/MAP3K8/MAPK14/RIPK1/MAP3K14/TRADD/XIAP/ATF2/ADAM17/VCAM1/IL15	1.75199182806367
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	35/1500	168/9376	1.30222222222222	H2AZ2/H2AZ1/STAT4/MACROH2A1/STAT1/BCL2/H2AC20/MAPK8/H2AJ/STAT5B/TNFAIP3/JAK1/CAMK2D/HMGB1/VPS4B/CHMP2A/EIF2AK2/CASP8/JAK3/H2AC17/CAPN2/VDAC1/IFNGR1/H2AC6/BAX/IFNG/RIPK1/FASLG/TRADD/XIAP/VDAC2/GLUD1/ZBP1/RBCK1/JAK2	1.72495112467021
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1500	32/9376	1.758	RPTOR/ATG7/ATG5/GABARAPL2/ATG13/PIK3C3/ATG10/WIPI1/IGBP1	1.87437375183518
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/1500	142/9376	1.32056338028169	FYN/CAMK4/STAT1/MAPK8/NFATC2/CYBA/PPP3CC/RELB/JAK1/PIK3R1/PPP3CA/LCK/TGFBR2/RAC1/TGFB1/CREB1/NFKB1/ITPR1/PPP3CB/GAB2/MAPK1/MAP2K1/TAB2/PIK3CD/PIK3CB/IFNGR1/MAPK14/IFNG/MAP3K14/ATP2A3	1.67973804988242
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	25/1500	115/9376	1.35884057971014	FYN/CAMK4/PIK3R5/GNG2/BCL2/GNAQ/GNB1/PRKCB/PLCB1/KCNQ5/PIK3R1/CAMK2D/PRKCA/PRKACB/GNG5/CREB1/GNB5/ITPR1/MAPK1/MAP2K1/PIK3CD/PIK3CB/CACNA1D/KRAS/JAK2	1.68966240715496
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1500	68/9376	1.47074509803922	RUNX1/BRAF/SOS1/STAT5B/PIK3R1/SOS2/NFKB1/LEF1/MAPK1/RAF1/MAP2K1/TCF7/PIK3CD/PIK3CB/RPS6KB1/KRAS	1.70016272127013
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	32/1500	154/9376	1.29883982683983	CAMK4/PIK3R5/CAMK1D/NFATC2/CALM1/GNAQ/MYL6/PRKCB/PPP3CC/ACTG1/ACTB/PLCB1/PPP1CA/PPP3CA/CAMK2D/PRKCA/PRKACB/PPP1R12A/ITPR1/PPP3CB/NFATC3/MAP2K5/PPP1CB/MAPK1/RAF1/CACNB2/MAP2K1/PPP1R12B/PRKAA1/MYL9/CACNA1D/KRAS	1.63179159393464
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	43/1500	216/9376	1.24434567901235	RAP1B/BCL2/MAPK8/MAP2K4/RAP1A/NFATC2/CYBA/CALM1/TRAF3/PPP3CC/MAP3K5/VAV1/PLCB1/PIK3R1/TANK/PPP3CA/CAMK2D/CXCL8/PRKCA/RAC1/POU2F1/VAV3/NFKB1/GSK3B/ITPR1/PPP3CB/NFATC3/NFE2L2/EIF2AK3/MAPK1/TAB2/CASP8/PIK3CD/TBK1/PIK3CB/CYCS/MAPK14/BAX/FASLG/BCL2L1/KRAS/JAK2/VCAM1	1.58548528674619
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1500	53/9376	1.53318238993711	RAB11A/GNAQ/PRKCB/PLCB1/ATP2B1/PRKCA/ATP2B4/PRKACB/AP2B1/DNM2/ATP1B3/CLTB/ESR1	1.69869067878616
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/1500	38/9376	1.64491228070175	PRKCB/PIK3R1/PRKCA/NR3C2/MAPK1/PIK3CD/ATP1B3/PIK3CB/SFN/KRAS	1.73837682880449
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/1500	69/9376	1.44942995169082	CAMK4/CALM1/PRKCB/PPP3CC/SLC18A2/PPP1CA/PPP3CA/CAMK2D/PRKCA/PRKACB/CREB1/PPP3CB/PPP1CB/HDAC1/CACNA1D/ATF2	1.63515947205201
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	39/1500	195/9376	1.25013333333333	H3-3B/H3-3A/H4C3/H2AZ2/H2AZ1/MACROH2A1/H2AC20/H2AJ/CYBA/PRKCB/ACTG1/HDAC4/ACTB/ATG7/PLCB1/SELPLG/RAC2/PIK3R1/PRKCA/RAC1/HMGB1/NFKB1/H3C4/ITGAL/MAPK1/RAF1/MAP2K1/PIK3CD/H2AC17/VDAC1/H4C5/PIK3CB/MAPK14/H2AC6/HDAC1/H2BC12/HAT1/VDAC2/CASP4	1.54036022796791
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/1500	75/9376	1.41681777777778	BCL2/COP1/CCND3/CDK6/SIVA1/ATR/THBS1/CASP8/PPM1D/CYCS/BAX/SHISA5/GADD45A/SFN/CDKN2A/BCL2L1/PERP	1.58157742507127
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1500	130/9376	1.29821538461538	GNG2/MAPK8/MAP2K4/GNB1/SOS1/PLCB1/PIK3R1/TGFBR2/PRKCA/PRKACB/TGFB1/GNG5/SOS2/CREB1/GNB5/NFKB1/MAPK1/RAF1/MAP2K1/PIK3CD/COL3A1/PIK3CB/MAPK14/SMAD2/KRAS/ATF2/PRKCZ	1.49418093278141
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	23/1500	109/9376	1.31894801223242	PRKCQ/MAPK8/PRKCB/FOXO1/RPS6KA3/PRKCE/PPP1CA/PIK3R1/CREB1/NFKB1/GSK3B/OGT/PTPN1/PPP1CB/OGA/PIK3CD/PRKAA1/PIK3CB/RPS6KB1/CPT1A/PTPN11/PRKCZ/G6PC3	1.46164525591118
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	48/1500	250/9376	1.200128	CTSW/ATP6V1G1/LITAF/ATP6V0E1/NPC1/RPTOR/AP3B1/OSBPL3/SUMF1/LAMTOR4/WDR7/RAB7A/ARL8B/MCOLN2/AP2B1/ARSG/HGSNAT/MEAK7/AP1G1/CTSS/AP3M2/DMXL1/MANBA/SLC38A9/OSTM1/LAMTOR1/LAMTOR5/BLOC1S2/GGA2/VPS26A/ABCA5/SPG11/VPS41/ATP6V1E1/MFSD8/NCOA7/ATP6V1H/AP4S1/OSBPL1A/PIKFYVE/SLC15A4/CLTB/DTNBP1/GPR155/M6PR/VPS35/GALC/SLC36A4	1.39963901945239
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/1500	93/9376	1.344229390681	MAPK8/MAP2K4/CALM1/GNAQ/PRKCB/SOS1/PLCB1/MAP3K2/CAMK2D/PRKCA/PRKACB/SOS2/ITPR1/MAPK1/RAF1/MAP2K1/MAPK14/MAP3K3/CACNA1D/KRAS	1.45587356749631
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1500	51/9376	1.47074509803922	ATP6V1G1/ATP6V0E1/SEC61G/ACTG1/ACTB/SEC61B/PRKCA/PRKACB/ARF1/ATP6V1E1/ATP6V1H/SEC61A2	1.47104137537761
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/1500	62/9376	1.41144086021505	FOXO1/RPTOR/PIK3R1/IGF1R/PRKACB/ATG5/CRYAB/PIK3CD/PRKAA1/PIK3CB/HDAC1/RPS6KB1/FOXO3/KRAS	1.41844846370244
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	25/1500	122/9376	1.28087431693989	RAB2A/PPP2R5C/PPP2R2B/FOXO1/RPTOR/PIK3R1/IGF1R/PPP2R2D/CREB1/PPP2R5A/RAB10/PPP2R3A/PPP2R3C/RAB8A/PPP2R5E/PIK3CD/PRKAA1/PIK3CB/PPP2R2A/RPS6KB1/FOXO3/CPT1A/CAB39/RHEB/G6PC3	1.36271680296338
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1500	139/9376	1.25912709832134	BCL2/NCOA1/KRT24/CALM1/NCOA2/GNAQ/OPRM1/ESR2/SOS1/KRT10/PLCB1/PIK3R1/NCOA3/KRT17/PRKACB/KRT14/SOS2/CREB1/ITPR1/MAPK1/RAF1/MAP2K1/FKBP5/PIK3CD/PIK3CB/KRAS/ATF2/ESR1	1.34317677631636
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	33/1500	168/9376	1.22780952380952	STAT4/PIAS1/STAT1/IL21R/BCL2/CCND3/SOS1/STAT5B/JAK1/PIK3R1/SOS2/PTPN2/CREBBP/IL12RB2/PRL/RAF1/PIK3CD/JAK3/IL2RB/PIK3CB/IL3RA/IFNGR1/IL4R/IL24/IFNG/OSM/STAM/BCL2L1/CSHL1/PTPN11/JAK2/IL7/IL15	1.30023626792368
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	31/1500	157/9376	1.23420806794055	ELMO1/ATP8A1/NFATC2/ATP11B/CAMK2D/CX3CR1/RAC1/VPS8/TGFB1/RAB7A/CREB1/UQCRFS1/GPR132/NFATC3/MAPK1/MAP2K1/THBS1/ADAM10/ANO6/CD47/HIF1A/PECAM1/MAPK14/VPS41/PLA2G6/CPT1A/RAB5A/ADAM17/ATP2A3/PTPN11/JAK2	1.29148148432222
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1500	107/9376	1.28518380062305	PDE3B/SIK1/CALM1/GNAQ/SIK2/PPP3CC/FOXO1/PLCB1/PPP3CA/CAMK2D/PRKACB/PPP4R3B/CREB1/CREBBP/ITPR1/PPP3CB/PHKB/PPP4R3A/PRKAA1/CPT1A/ATF2/G6PC3	1.29472851890523
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1500	32/9376	1.56266666666667	BCL2/MAPK8/BIRC6/CASP8/CYCS/BAX/XIAP/BCL2L1	1.39135571376332
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1500	154/9376	1.21766233766234	PIK3R5/BCL2/PPP2R5C/CALM1/RPS6KA5/GNAQ/PPP2R2B/PLCB1/PPP1CA/CAMK2D/ATP2B1/PRKCA/ATP2B4/PRKACB/PPP2R2D/CREB1/PPP2R5A/PPP2R3A/PPP1CB/PPP2R3C/MAPK1/CACNB2/PPP2R5E/TPM4/ATP1B3/MAPK14/PPP2R2A/CACNA1D/ATF2/ATP2A3	1.18852823825231
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/1500	13/9376	1.92328205128205	XRCC5/XRCC6/PRKDC/XRCC4	1.45370730014665
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/1500	65/9376	1.34629743589744	GNAQ/ESR2/PRKCB/PLCB1/PIK3R1/PRKCA/ITPR1/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/CACNA1D/KRAS	1.2226051050915
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	34/1500	178/9376	1.19394756554307	MAPK8/NFATC2/DKK1/TBL1X/PRKCB/CCND3/PPP3CC/FBXW11/PLCB1/RAC2/PPP3CA/CAMK2D/RBX1/PRKCA/RAC1/PRKACB/BTRC/TBL1XR1/PSEN1/GSK3B/CCDC88C/NLK/CREBBP/PPP3CB/NFATC3/CUL1/LEF1/CSNK2A1/SENP2/INVS/TCF7/WNT5A/LGR6/RYK	1.14005563406155
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	19/1500	93/9376	1.27701792114695	BCL2/TRAF3/CDK6/PIK3R1/RB1/NFKB1/CDKN1B/PIK3CD/TRAF1/MAX/PIK3CB/CYCS/BAX/ITGB1/GADD45A/XIAP/BCL2L1/ZBTB17/LAMB3	1.17161137322631
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	15/1500	71/9376	1.32056338028169	MAPK8/MAP2K4/ATP6V1G1/ATP6V0E1/CXCL8/RAC1/NFKB1/ADAM10/NOD1/MAPK14/ATP6V1E1/ATP6V1H/MAP3K14/ADAM17/PTPN11	1.18321402439865
Human Diseases	Substance dependence	hsa05034	Alcoholism	36/1500	191/9376	1.17813612565445	H3-3B/H3-3A/H4C3/H2AZ2/H2AZ1/MACROH2A1/CAMK4/GNG2/H2AC20/H2AJ/BRAF/CALM1/GNB1/SOS1/HDAC4/SLC18A2/PPP1CA/PRKACB/GNG5/SOS2/CREB1/GNB5/H3C4/PPP1CB/MAPK1/RAF1/MAP2K1/H2AC17/H4C5/H2AC6/HDAC1/H2BC12/HAT1/PKIA/KRAS/ATF2	1.08544424347851
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	27/1500	140/9376	1.20548571428571	CAMK4/PIK3R5/PDE3B/GNG2/NRF1/CALM1/GNAQ/GNB1/HDAC4/PRKCE/PLCB1/KLF2/PRKACB/GNG5/GNB5/ITPR1/MAPK1/RAF1/MAP2K1/RRAS2/PIK3C3/GNA13/PRKAA1/SMAD2/RPS6KB1/KRAS/PLAT	1.06901082773071
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/1500	56/9376	1.33942857142857	BCL2/CUL3/FBXW11/PRKACB/BTRC/GSK3B/CUL1/DISP1/SMURF2/SMURF1/GAS1/CSNK1G3	1.11176466702441
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1500	73/9376	1.28438356164384	BRAF/CDK6/PIK3R1/IGF1R/RB1/PDGFD/MAPK1/RAF1/MAP2K1/PIK3CD/PIK3CB/BAX/GADD45A/CDKN2A/KRAS	1.06446852061667
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	37/1500	201/9376	1.15062023217247	H3-3B/H3-3A/KDM6A/ZEB1/RUNX1/GZMB/ETV6/AFF1/SUPT3H/FOXO1/MLLT3/BCL11B/NCOR1/IGF1R/CXCL8/TGFBR2/NFKB1/H3C4/FLI1/FUT8/CCNT1/CDKN1B/TRAF1/MAX/IL2RB/PBX3/BMP2K/HDAC1/BAX/GADD45A/BCL2L1/CCNT2/ZBTB17/PLAT/DEFA3/SS18/ITGB7	0.94201261553115
Genetic Information Processing	Transcription	hsa03040	Spliceosome	44/1500	243/9376	1.13180795610425	U2AF1/SRSF5/SNRPB2/SF3B6/SNRPD2/HNRNPA1/HNRNPC/LSM6/LSM7/SRSF4/TXNL4A/CCDC12/ZMAT2/MAGOH/CDC40/BCAS2/SNRPG/SYF2/U2SURP/SNRPF/AQR/PRPF6/SF3B5/SNRPD1/HNRNPM/THOC1/YJU2/THOC7/SF3B2/SNIP1/CWC15/LSM3/THOC2/DHX8/SNRPE/LSM8/PRPF18/LSM5/SNW1/NCBP1/LSM4/PPIH/WBP11/EFTUD2	0.908482252443084
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1500	36/9376	1.38903703703704	GALNT11/ST3GAL1/GALNT2/B4GALT5/GALNT10/GCNT4/C1GALT1/GALNT1	1.02058028633182
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/1500	115/9376	1.19577971014493	PDE4D/BCL2/PDE4B/BRAF/GNAQ/PRKCB/NACA/PLCB1/OXSR1/MMP24/AKAP13/PRKCA/PRKACB/STK39/CREB1/ITPR1/PDE4A/MAPK1/RAF1/MAP2K1/GNA13/ATF2	0.921862339490102
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1500	110/9376	1.19330909090909	DCN/EMP3/NCOR1/RBX1/TGFBR2/TGFB1/CREBBP/CUL1/MAPK1/RBL1/LEMD3/THBS1/ACVR2A/BMPR2/SMURF2/HDAC1/IFNG/SMURF1/NEO1/SMAD2/RPS6KB1	0.8899813114665
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/1500	70/9376	1.25013333333333	FYN/ACTG1/PRF1/ACTB/SNTB1/RAC2/RAC1/EIF4G3/SGCE/ITGAL/CASP8/CYCS/ABL2/ABL1	0.916679418449196
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1500	157/9376	1.15458174097665	PPP2R2B/CCND3/ACTG1/ACTB/FBXW11/DLG1/PPP1CA/YWHAB/TGFBR2/AREG/PPP2R2D/BTRC/TGFB1/YWHAZ/GSK3B/PATJ/PPP1CB/LEF1/TCF7/BMPR2/PPP2R2A/SMAD2/PALS1/WNT5A/DLG3/RASSF1/LATS1/PRKCI/PRKCZ	0.852402131323267
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1500	59/9376	1.27132203389831	DPYD/NT5C2/RRM1/ASMTL/NME7/HDDC2/NME3/NT5C3A/CMPK1/NT5E/CDA/CTPS1	0.912328907886829
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	19/1500	99/9376	1.1996228956229	PRKCH/PRKCQ/MAPK8/CALM1/GNAQ/PRKCB/PRKCE/PLCB1/PPP1CA/PIK3R1/CAMK2D/PRKCA/PRKACB/ITPR1/PPP1CB/PIK3CD/PIK3CB/MAPK14/PLA2G6	0.871369960284412
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	24/1500	128/9376	1.172	ADSS2/PDE7A/PDE3B/PDE4D/ADK/PDE4B/NT5C2/APRT/RRM1/GUK1/PDE7B/PDE5A/PDE4A/PDE8A/AK5/NME7/DGUOK/NUDT5/ADA2/HPRT1/HDDC2/NME3/NT5E/GMPS	0.855042959242094
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	10/1500	48/9376	1.30222222222222	PCCA/OXCT1/AUH/HIBADH/ACAT1/ACSF3/DLD/BCKDHB/ACADSB/HADHB	0.916075268543753
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1500	134/9376	1.16616915422886	PRKCH/PRKCQ/BRAF/CALM1/GNAQ/MYL6/PRKCB/PRKCE/PLCB1/PPP1CA/PRKCA/PRKACB/MYH9/PPP1R12A/ITPR1/PPP1CB/MAPK1/RAF1/MAP2K1/PPP1R12B/GNA13/RAMP1/MYL9/PLA2G6/CACNA1D	0.845470074828507
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/1500	37/9376	1.3514954954955	HBB/GNAQ/PRKCB/PLCB1/PRKCA/IFNG/FASLG/VCAM1	0.934864895381441
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1500	37/9376	1.3514954954955	BRAF/LEF1/MAPK1/MAP2K1/TCF7/BAX/GADD45A/KRAS	0.934864895381441
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1500	21/9376	1.48825396825397	CHST11/CSGALNACT1/CSGALNACT2/UST/CHSY3	0.977489153682143
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1500	60/9376	1.25013333333333	BRAF/GNAQ/PRKCB/PLCB1/IGF1R/PRKCA/ITPR1/MAPK1/RAF1/MAP2K1/GNA13/KRAS	0.848224612302766
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	14/1500	72/9376	1.21540740740741	RNF125/MAPK8/TRAF3/TANK/CXCL8/ATG5/NFKB1/ZNFX1/CASP8/PIN1/TBK1/MAPK14/RIPK1/TRADD	0.800701136693875
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1500	166/9376	1.12963855421687	PIK3R5/PDE3B/NFATC2/CALM1/GNAQ/PPP3CC/PRKCE/PLCB1/PPP1CA/PPP3CA/ATP2B1/ATP2B4/PPP1R12A/CREB1/ITPR1/PPP3CB/PDE5A/NFATC3/PPP1CB/MAPK1/RAF1/MAP2K1/GNA13/VDAC1/ATP1B3/MYL9/CACNA1D/VDAC2/ATF2/ATP2A3	0.735422345976327
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1500	33/9376	1.32589898989899	VTI1A/STX8/STX5/VAMP5/VAMP3/VTI1B/GOSR1	0.81841809682694
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	27/1500	149/9376	1.1326711409396	FYN/PIK3R5/CYTH1/SOS1/PLCB1/PIK3R1/CXCL8/PRKCA/SOS2/PDGFD/AGPAT3/GAB2/MAPK1/DNM2/RAF1/MAP2K1/RRAS2/PIK3CD/GNA13/RALA/F2R/AGPAT4/PIK3CB/ARF1/KRAS/RHEB/PTPN11	0.712389897225093
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	10/1500	50/9376	1.25013333333333	HBB/CXCL8/KLRC4-KLRK1/TGFB1/KLRB1/ITGAL/THBS1/PECAM1/IFNG/VCAM1	0.773904338389056
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1500	91/9376	1.16770695970696	PDE7A/PDE3B/PDE4D/GNG2/GRK5/PDE4B/OPRM1/GNB1/PRKCB/PRKCA/PDE7B/PRKACB/GNG5/GNB5/PDE4A/PDE8A/GRK6	0.701550990248306
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1500	62/9376	1.2098064516129	MAML2/ATXN1/KAT2B/CIR1/PSEN1/CREBBP/MAML3/HDAC1/NUMB/SNW1/NCOR2/ADAM17	0.72331085155138
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/1500	180/9376	1.11122962962963	STAT1/BCL2/SRSF5/TRAF3/PDIA3/PPP1CA/SP100/JAK1/PIK3R1/SRSF4/POU2F1/NFKB1/PPP1CB/EIF2AK2/BST2/TAB2/CASP8/PIK3CD/TBK1/PIK3CB/CYCS/IFNGR1/BAX/IFNG/SRPK1/FASLG/TRADD/EIF2B3/BCL2L1/RHEB/PTPN11/JAK2	0.657560438444796
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1500	57/9376	1.20626900584795	ELOVL5/SCP2/HACD4/HSD17B12/ACAT1/HACD3/ACSL5/ACSF3/CPT1A/ACADSB/HADHB	0.68165584245562
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1500	23/9376	1.35884057971014	PDSS2/NUS1/PDSS1/ACAT1/FDPS	0.751914421316786
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1500	18/9376	1.38903703703704	LMBRD1/MTR/ZNF76/MMAA	0.720964855721153
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1500	226/9376	1.07865486725664	CAMK4/PDE3B/PDE4D/RAP1B/MAPK8/RAP1A/PDE4B/BRAF/CALM1/VAV1/PPP1CA/RAC2/PIK3R1/CAMK2D/ATP2B1/RAC1/ATP2B4/PRKACB/PPP1R12A/VAV3/CREB1/NFKB1/CREBBP/PDE4A/PPP1CB/MAPK1/ABCC4/RAF1/MAP2K1/RRAS2/PIK3CD/TIAM1/ATP1B3/F2R/PIK3CB/MYL9/CACNA1D/ATP2A3/VIPR2	0.522333269872722
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	17/1500	94/9376	1.13043971631206	MAPK8/TRAF3/TNFAIP3/CXCL8/NFKB1/S100A8/GSK3B/USP25/MAPK1/IL17RA/TAB2/CASP8/TBK1/MAPK14/IFNG/TRADD/MAPK6	0.554665820063602
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	13/1500	71/9376	1.1444882629108	PIK3R1/SLC16A3/MAPK1/RAF1/MAP2K1/PIK3CD/HIF1A/PIK3CB/PDK1/IDH2/SLC7A5/SIRT3/KRAS	0.533312753586598
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1500	19/9376	1.3159298245614	OGDH/DLD/BCKDHB/DLST	0.601558026717289
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/1500	78/9376	1.12191452991453	STAT1/CYBA/PRKCB/ITGA4/JAK1/TGFB1/NFKB1/MAPK1/TAB2/IFNGR1/MAPK14/IFNG/ITGB1/JAK2	0.471830936504343
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	31/1500	181/9376	1.0705561694291	STAT1/BCL2/MAPK8/CALM1/PPP3CC/JAK1/PPP3CA/CAMK2D/MALT1/TGFB1/RAB7A/CREB1/NFKB1/CREBBP/PPP3CB/CORO1A/CTSS/MAPK1/RAF1/CASP8/PIK3C3/CYCS/IFNGR1/MAPK14/BAX/IFNG/ATP6V1H/EEA1/TRADD/RAB5A/JAK2	0.418289371064699
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1500	31/9376	1.2098064516129	PCCA/ACO2/MDH1/MDH2/ACAT1/DLD	0.510608978121005
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1500	109/9376	1.08956574923547	STAT1/MAPK8/MAP2K4/TRAF3/JAK1/PIK3R1/CXCL8/RAC1/NFKB1/MAPK1/MAP2K1/TAB2/CASP8/PIK3CD/TBK1/PIK3CB/MAP3K8/MAPK14/RIPK1	0.410453576888151
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1500	49/9376	1.14808163265306	B4GALT1/GALNT11/OGT/ST6GAL1/GALNT2/GALNT10/B3GLCT/C1GALT1/GALNT1	0.453530668024783
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1500	14/9376	1.33942857142857	B4GALT1/ST3GAL1/FUT8	0.554634026423791
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	17/1500	98/9376	1.08429931972789	CAMK4/CAMK1D/CALM1/GNAQ/PRKCB/PRKCE/PLCB1/CAMK2D/ATP2B1/PRKCA/ATP2B4/PRKACB/CREB1/ITPR1/ATP1B3/CACNA1D/ATF2	0.366090397672984
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1500	32/9376	1.172	SUCLG2/PCCA/SUCLA2/ECHDC1/DLD/BCKDHB	0.425319637619593
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/1500	50/9376	1.12512	CXCR4/ITGA4/TGFB1/ICOS/CCR9/MAP3K14/CCL28/ITGB7/IL15	0.387117180780538
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/1500	38/9376	1.15143859649123	CD3D/CD3E/CD8A/CD8B/LCK/ICOS/JAK3	0.408206441410238
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1500	148/9376	1.05585585585586	NCOA1/BRAF/ESR2/SOS1/CDK6/PIK3R1/IGF1R/NCOA3/RB1/SOS2/GSK3B/LEF1/MAPK1/RAF1/MAP2K1/TCF7/PIK3CD/PIK3CB/BRCA1/BAX/RPS6KB1/GADD45A/WNT5A/KRAS/ESR1	0.298898812398275
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1500	112/9376	1.06038095238095	PIK3R5/STAT1/BCL2/MAPK8/JAK1/TGFB1/NFKB1/MAPK1/TAB2/CASP8/CYCS/IFNGR1/MAPK14/IFNG/ITGB1/XIAP/BCL2L1/JAK2/LAMB3	0.280535683871531
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1500	33/9376	1.13648484848485	OGDH/ACO2/IDH2/DLD/BCKDHB/DLST	0.342749359172006
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1500	27/9376	1.15753086419753	ELOVL5/SCP2/HACD4/HSD17B12/HACD3	0.357720123230919
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1500	15/9376	1.25013333333333	AK5/TPK1/ACP1	0.423091686271638
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1500	21/9376	1.19060317460317	DPYD/PPCS/PANK2/VNN2	0.381589393934173
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1500	101/9376	1.05209240924092	CALM1/GNAQ/PRKCB/PLCB1/CAMK2D/PRKCA/PRKACB/CREB1/GSK3B/CREBBP/LEF1/MAPK1/RAF1/MAP2K1/TCF7/WNT5A/KRAS	0.229697667699093
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/1500	89/9376	1.05348314606742	GNAQ/PRKCB/SOS1/PLCB1/MAP3K2/PRKCA/PRKACB/SOS2/PDGFD/ITPR1/MAP2K5/MAPK1/RAF1/MAP2K1/KRAS	0.221234391732187
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1500	83/9376	1.05432931726908	POLR2L/SAMHD1/NFKB1/POLR3GL/POLR2K/CASP8/POLR1C/TBK1/POLR2F/RIPK1/ZDHHC11B/POLR3C/ZBP1/POLR3B	0.216957036035581
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1500	28/9376	1.11619047619048	ELOVL5/HACD4/HSD17B12/HACD3/HADHB	0.268700583425062
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1500	47/9376	1.06394326241135	MAPK8/PRKCE/PIK3R1/MAPK1/PIK3CD/PIK3CB/CACNA1D/PRKCZ	0.191780561930684
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/1500	103/9376	1.03166343042071	GNAQ/PRKCB/PLCB1/PIK3R1/CXCL8/PRKCA/PRKACB/TGFB1/RAB7A/NFKB1/PIK3CD/COL3A1/PIK3CB/IFNG/RAB5A/VCL/LAMB3	0.141008359840411
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/1500	97/9376	1.03103780068729	GNG2/CALM1/RPS6KA5/GNAQ/GNB1/PRKCB/PLCB1/CAMK2D/PRKCA/PRKACB/GNG5/CREB1/GNB5/ITPR1/MAPK1/CACNA1D	0.134092545055906
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/1500	66/9376	1.04177777777778	STAT4/STAT1/IL21R/RORA/TGFB1/NFKB1/IL12RB2/IFNGR1/IL4R/IFNG/SMAD2	0.14863492788786
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1500	48/9376	1.04177777777778	PRKCB/PLCB1/PIK3R1/PIK3CD/ATP1B3/PIK3CB/CACNA1D/G6PC3	0.126633934181048
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1500	23/9376	1.08707246376812	ATP1B3/MDH1/SLC4A4/GLUD1	0.182451609178968
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1500	17/9376	1.10305882352941	MARS1/MTR/KYAT3	0.185598016897321
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1500	17/9376	1.10305882352941	CA5B/CA6/GLUD1	0.185598016897321
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1500	150/9376	1.00010666666667	BCL2/BRAF/SOS1/PIK3R1/RB1/TGFBR2/TGFB1/SOS2/GSK3B/LEF1/MAPK1/RAF1/CDKN1B/MAP2K1/TCF7/PIK3CD/PIK3CB/BAX/SMAD2/ABCB1/RPS6KB1/GADD45A/WNT5A/KRAS	0.000574706411208344
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1500	30/9376	1.04177777777778	PIGU/PGAP1/PIGP/PIGB/PIGA	0.100016462190012
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1500	144/9376	0.99837037037037	MAPK8/MAP2K4/TRAF3/MAP3K5/FOXO1/CXCL8/NFKB1/GSK3B/LEF1/IL17RA/TCF7/TAB2/CASP8/PRKAA1/TBK1/MAPK14/RIPK1/FASLG/MAP3K14/FOXO3/CPT1A/ADH5/TRADD	-0.00860004402483288
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/1500	69/9376	0.99648309178744	PDE3B/CALM1/GNAQ/PPP3CC/PLCB1/PPP3CA/PRKACB/CREB1/ITPR1/PPP3CB/CACNA1D	-0.0127955552460861
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1500	44/9376	0.994424242424242	HMGB1/ADPRS/PARP4/POLB/RFC1/PARG/POLE4	-0.0161778673574478
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1500	44/9376	0.994424242424242	RAB11A/ARHGDIB/DCTN4/PRKACB/CREB1/RAB5A/DCTN5	-0.0161778673574478
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1500	102/9376	0.980496732026144	RAB11A/RAP1B/RAP1A/GNAQ/PRKCB/PLCB1/ATP2B1/PRKCA/RAC1/ATP2B4/ITPR1/RAB8A/ATP1B3/SLC4A4/RAB27B/ATP2A3	-0.0864275778693214
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1500	70/9376	0.982247619047619	PRKCQ/MAPK8/NFKB1/PRKAA1/ACSL5/APPL1/CPT1A/TRADD/PTPN11/JAK2/G6PC3	-0.0650582712454042
NA	NA	hsa04518	Integrin signaling	24/1500	154/9376	0.97412987012987	CCND3/ACTG1/ITGA4/ACTB/RAC2/PIK3R1/IGF1R/RAC1/TGFB1/GSK3B/PDGFD/PXN/ITGAL/THBS1/ARHGEF6/PIK3CD/NCK2/PIK3CB/ITGB1/COL6A2/VCL/LAMB3/VCAM1/ITGB7	-0.141261828794666
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1500	12/9376	1.04177777777778	NPC1/NCAM1	0.0631951385000916
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1500	52/9376	0.961641025641026	TSPO/NPC1/LIPC/VAPA/STARD3NL/VDAC1/LDLRAP1/VDAC2	-0.121044745008977
Cellular Processes	Cell motility	hsa04814	Motor proteins	30/1500	194/9376	0.96659793814433	DYNLT1/MYL12A/CAPZA1/MYL12B/MYL6/ACTG1/CAPZB/ACTB/DCTN4/MYH9/KIF13B/KIFAP3/BICDL1/MYO1F/MYO1D/ACTR10/DCTN3/MYO9B/KIF2A/CAPZA2/MYO5A/TPM4/HOOK3/MYL9/DNAI3/MYL11/DYNLT3/MYO9A/DCTN5/KIF1B	-0.205155852522019
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1500	59/9376	0.953491525423729	RRM1/GSTP1/GPX1/GSTK1/MGST3/IDH2/MGST1/LANCL1/GGT7	-0.156386214595294
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1500	47/9376	0.930950354609929	ACYP2/MDH1/MDH2/ACAT1/DLD/ACYP1/ADH5	-0.207095779831094
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/1500	100/9376	0.9376	CD3G/CD3D/CD3E/ITGA4/CD8A/CD8B/CD2/CD7/CD5/CD37/CD44/IL3RA/IL4R/CD9/IL7	-0.27376796875567
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	33/1500	217/9376	0.950562211981567	BCL2/ESR2/PRKCB/CCND3/SOS1/STAT5B/RPS6KA3/PIK3R1/RB1/PRKCA/PRKACB/SOS2/CREB1/NFKB1/KPNA6/MAPK1/RAF1/MAP2K1/KPNA1/MGST3/PIK3CD/PIK3CB/RPS6KB1/AIP/XIAP/CACNA1D/KPNA5/KRAS/ATF2/ESR1/KPNA3/MGST1/JAK2	-0.321546126630057
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1500	41/9376	0.914731707317073	BABAM2/RAD51B/SEM1/RPA3/TOPBP1/BRCA1	-0.238781539802405
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1500	75/9376	0.916764444444444	TG/GNAQ/PRKCB/PLCB1/PRKCA/PRKACB/CREB1/ITPR1/GPX1/ATP1B3/ATF2	-0.31582980057083
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1500	55/9376	0.909187878787879	SGMS1/CERS6/CERS5/B4GALT5/SPTLC2/SPTLC1/SMPD4/GALC	-0.294762563537438
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1500	28/9376	0.892952380952381	PTS/GPHN/PCBD2/GCH1	-0.247556930958828
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/1500	115/9376	0.924011594202899	GNG2/BRAF/GNAQ/GNB1/PRKCB/PLCB1/SLC18A2/PRKCA/PRKACB/GNG5/GNB5/ITPR1/MAPK1/RAF1/MAP2K1/CACNA1D/KRAS	-0.357804439951328
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/1500	155/9376	0.927518279569892	CYBA/ATP6V1G1/ATP6V0E1/SEC61G/ACTG1/ACTB/SEC61B/RAC1/RAB7A/CORO1A/CTSS/STX12/THBS1/PIK3C3/ATP6V1E1/ITGB1/ATP6V1H/EEA1/VAMP3/PIKFYVE/RAB5A/SEC61A2/M6PR	-0.397085240944592
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/1500	155/9376	0.927518279569892	RAP1B/RAP1A/BRAF/GNAQ/CDK6/PLCB1/CAMK2D/RB1/PRKACB/CREB1/GSK3B/ITPR1/PDE8A/LEF1/MAPK1/CDKN1B/MAP2K1/TCF7/AIP/CACNA1D/WNT5A/CDKN2A/ATF2	-0.397085240944592
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	11/1500	76/9376	0.904701754385965	CALM1/GNAQ/PRKCB/ACTG1/ACTB/PLCB1/CAMK2D/PRKCA/PRKACB/ITPR1/ATP1B3	-0.364022846603542
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1500	116/9376	0.916045977011494	GNG2/SLC38A1/GNAQ/GNB1/PRKCB/PPP3CC/PLCB1/PPP3CA/PRKCA/PRKACB/GNG5/GNB5/ITPR1/PPP3CB/MAPK1/DLGAP1/CACNA1D	-0.397048378886681
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/1500	83/9376	0.903710843373494	PEX14/FAR1/SCP2/PRDX5/GSTK1/ABCD3/AGPS/HACL1/IDH2/ACSL5/PEX2/PEX16	-0.384518176817644
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1500	29/9376	0.86216091954023	CALM1/GNB1/RGS9/SLC24A1	-0.324424511089119
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1500	36/9376	0.868148148148148	RNASEH2B/PRIM2/RFC1/RPA3/POLE4	-0.345893547157394
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1500	43/9376	0.872186046511628	ACAT1/ACSL5/CPT1A/ADH5/ACADSB/HADHB	-0.366589715896808
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	21/1500	144/9376	0.911555555555556	JARID2/KAT6A/JAK1/PIK3R1/IGF1R/GSK3B/MAPK1/PCGF5/RAF1/MAP2K1/TCF7/PIK3CD/JAK3/ACVR2A/BMPR2/PIK3CB/MAPK14/SMAD2/WNT5A/KRAS/JAK2	-0.466747843893188
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1500	15/9376	0.833422222222222	ST3GAL1/ST8SIA1	-0.281760419357871
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1500	51/9376	0.857934640522876	PLAAT2/PAFAH1B1/SELENOI/CHPT1/AGPS/PEDS1/PLA2G6	-0.443943065300563
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1500	23/9376	0.815304347826087	ATP6AP2/PRCP/PREP	-0.38701120295885
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1500	86/9376	0.872186046511628	ACTG1/ITGA4/ACTB/SNTB1/SGCE/LEF1/CACNB2/TCF7/ITGB1/CACNA1D/ATP2A3/ITGB7	-0.519634588179643
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	23/1500	160/9376	0.898533333333333	CD6/GLG1/CD99/ITGA4/CD8A/CD8B/SELPLG/CD2/ICOS/ITGAL/NLGN4X/VCAN/ALCAM/SELL/NCAM1/TIGIT/PECAM1/CD226/NEO1/ITGB1/CD58/VCAM1/ITGB7	-0.564924702612835
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/1500	45/9376	0.833422222222222	GZMB/PRF1/KLRD1/IFNG/FASLG/KLRC1	-0.488807251716408
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1500	16/9376	0.781333333333333	ST3GAL1/ST8SIA1	-0.382017330639996
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/1500	116/9376	0.86216091954023	OGDH/SUCLG2/PCCA/SUCLA2/ACO2/SDHB/PGK1/MDH1/TALDO1/MDH2/ACAT1/IDH2/DLD/ADH5/DLST/GLUD1	-0.651889945181965
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/1500	82/9376	0.83850406504065	DPYD/RRM1/GSTP1/NME7/MGST3/HPRT1/NME3/CMPK1/CDA/GMPS/MGST1	-0.640981656630557
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1500	54/9376	0.810271604938272	REV3L/WDR48/ATR/RPA3/BRCA1/FANCC/POLH	-0.610173128234398
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1500	89/9376	0.842786516853933	GNG2/SLC38A1/GNB1/PRKCB/PLCL1/PRKCA/PRKACB/GNG5/GNB5/GABARAPL2/GPHN/CACNA1D	-0.650317564940495
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1500	18/9376	0.694518518518519	ACSL5/ACSF3	-0.566119395467257
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1500	26/9376	0.721230769230769	CUBN/BTD/LMBRD1	-0.621160912456552
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1500	56/9376	0.781333333333333	RAB1A/CXCL8/NFKB1/CASP8/HBS1L/CYCS/ARF1	-0.716221008835029
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1500	49/9376	0.765387755102041	SLC18A2/PRKACB/CREB1/NFKB1/RGS9/ATF2	-0.718548588700786
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1500	99/9376	0.820794612794613	ACTG1/ITGA4/ACTB/SNTB1/TGFB1/SGCE/CACNB2/TPM4/PRKAA1/ITGB1/CACNA1D/ATP2A3/ITGB7	-0.782245897418998
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1500	78/9376	0.801367521367521	MAPK8/CALM1/CFL1/CXCL8/NFKB1/C1S/MAPK1/NOD1/MAPK14/ITGB1	-0.768743056951833
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1500	42/9376	0.744126984126984	ATG7/ATG5/ACSL5/SLC39A8/VDAC2	-0.725259871908607
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1500	10/9376	0.625066666666667	BPNT2	-0.517672852104841
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1500	65/9376	0.76931282051282	GNAQ/PLCB1/PRKACB/CREB1/ITPR1/PDE8A/CACNA1D/ATF2	-0.81444242458589
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1500	28/9376	0.669714285714286	ATP6V1G1/ATP6V0E1/ATP6V1E1	-0.763814445342717
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1500	20/9376	0.625066666666667	LBR/CYP2R1	-0.732491110072807
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1500	20/9376	0.625066666666667	GMDS/CYB5R3	-0.732491110072807
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1500	45/9376	0.694518518518519	ABCC4/ABCD3/ABCA5/ABCB1/ABCB7	-0.896407464460364
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/1500	104/9376	0.781333333333333	GPCPD1/PLAAT2/SGMS1/SELENOI/CHKA/AGPAT3/TAFAZZIN/CHPT1/GPD2/CDS2/AGPAT4/PLA2G6/GPD1L	-0.978567880493991
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1500	61/9376	0.717289617486339	MT2A/ATP2B1/ATP2B4/MT1F/MT1X/ATP1B3/SLC31A1	-0.966704321611276
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1500	105/9376	0.773892063492064	ACTG1/ITGA4/ACTB/SNTB1/PRKACB/TGFB1/SGCE/CACNB2/TPM4/ITGB1/CACNA1D/ATP2A3/ITGB7	-1.01677668597147
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1500	38/9376	0.657964912280702	NT5C2/SARM1/SIRT3/NT5E	-0.921963945984013
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1500	30/9376	0.625066666666667	NFKB1/ABCC4/MTR	-0.897594547909514
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1500	54/9376	0.694518518518519	MTAP/AHCYL2/MTR/MDH1/KYAT3/MDH2	-0.982439086740756
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1500	39/9376	0.641094017094017	GZMB/PRF1/IFNG/FASLG	-0.980139148687838
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/1500	143/9376	0.786797202797203	H3-3B/H3-3A/H4C3/H2AZ2/H2AZ1/MACROH2A1/H2AC20/H2AJ/H3C4/SSB/C1S/C7/SNRPD1/H2AC17/H4C5/H2AC6/IFNG/H2BC12	-1.12116082184367
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1500	93/9376	0.739326164874552	CALM1/GNAQ/PRKCB/PLCB1/ATP2B1/PRKCA/ATP2B4/PRKACB/ITPR1/ATP1B3/LYZ	-1.10248618093369
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1500	86/9376	0.726821705426357	GNAQ/PRKCB/PLCB1/CAMK2D/PRKCA/PRKACB/CREB1/ATP1B3/CACNA1D/ATF2	-1.11062123286333
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1500	23/9376	0.543536231884058	RFC1/RPA3	-0.956474015096668
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1500	79/9376	0.712101265822785	ATP6V1G1/ATP6V0E1/SLC18A2/AP2B1/NAPA/DNM2/ATP6V1E1/ATP6V1H/CLTB	-1.1213993487637
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1500	32/9376	0.586	B4GALT1/GALM/G6PC3	-1.023734476596
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1500	24/9376	0.520888888888889	EXT1/HS2ST1	-1.02557642354146
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1500	42/9376	0.595301587301587	KYAT3/ACAT1/DLD/DLST	-1.14709836812542
NA	NA	hsa04519	Cadherin signaling	55/1500	404/9376	0.850957095709571	MAPK8/KRT6A/EVL/KRT24/ARPC3/ARPC2/ARPC5/CYFIP2/ACTG1/VAV1/KRT10/ACTB/ACTR3/TAOK3/PPP1CA/RAC2/YWHAB/IGF1R/BRK1/KRT17/RAC1/KRT14/TMC8/YWHAZ/VAV3/KRT5/PSEN1/NFKB1/GSK3B/CREBBP/MYO1F/MYO1D/ERBIN/PPP1CB/LEF1/MAPK1/RAF1/RERE/MAP2K1/RRAS2/TCF7/ADAM10/SHOC2/ARPC4/MAPK14/ARHGAP35/LHFPL5/PALS1/ARPC5L/VIM/WNT5A/KRAS/LATS1/VCL/RYK	-1.33639785176158
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	30/1500	233/9376	0.80480686695279	DCN/CAPZA1/ACTG1/ITGA4/CAPZB/ACTB/SNTB1/MYH9/SGCE/TMOD3/ANKRD23/DIAPH1/VCAN/THBS1/CAPZA2/LBR/TPM4/ATP1B3/DIAPH2/COL3A1/PDLIM5/ITGB1/MYL9/MYL11/SYNE3/COL6A2/VIM/MYOM1/VCL/ITGB7	-1.31666881528053
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1500	59/9376	0.635661016949153	PDE3B/PLAAT2/PIK3R1/PRKACB/PIK3CD/PIK3CB	-1.22510133707742
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1500	26/9376	0.480820512820513	PLAAT2/PLA2G6	-1.15684935204381
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1500	44/9376	0.568242424242424	GZMB/PRF1/IFNG/FASLG	-1.2527296418963
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1500	36/9376	0.520888888888889	GYG1/GBE1/G6PC3	-1.25687610281687
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1500	27/9376	0.463012345679012	OXCT1/ACAT1	-1.21938828213574
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1500	17/9376	0.367686274509804	SCP2	-1.13872999408387
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1500	17/9376	0.367686274509804	GGT7	-1.13872999408387
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1500	17/9376	0.367686274509804	MYH9	-1.13872999408387
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1500	63/9376	0.595301587301587	PLAAT2/TBXAS1/PTGDS/PLA2G6/CBR3/PTGR3	-1.40648591790503
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1500	63/9376	0.595301587301587	GSK3B/LEF1/TCF7/BAX/GADD45A/WNT5A	-1.40648591790503
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1500	28/9376	0.44647619047619	B4GALT1/ST8SIA1	-1.28007195972661
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/1500	88/9376	0.639272727272727	A2M/C1S/CLU/C7/F2R/PLAUR/SERPIND1/PLAT/SERPINB2	-1.48367105816899
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1500	18/9376	0.347259259259259	MANBA	-1.20966152106146
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1500	29/9376	0.431080459770115	RASSF1/LATS1	-1.33903565717704
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1500	48/9376	0.520888888888889	VPS4B/TSG101/PDCD6IP/CD9	-1.45224873454436
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1500	39/9376	0.480820512820513	AHCYL2/MTR/DLD	-1.4178313118664
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/1500	82/9376	0.609821138211382	PDIA3/CD8A/CD8B/CREB1/KLRD1/CTSS/IFNG/KLRC1	-1.54863026908043
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1500	19/9376	0.328982456140351	HGSNAT	-1.27767611094418
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1500	30/9376	0.416711111111111	PLAAT2/PLA2G6	-1.39640005295928
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/1500	100/9376	0.625066666666667	CXCR4/CXCL8/CX3CR1/XCL2/CXCL14/CCR9/XCL1/IL2RB/IL24/CCL28	-1.64494770970287
NA	NA	hsa04981	Folate transport and metabolism	2/1500	31/9376	0.403268817204301	ABCC4/MTR	-1.45227326003502
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/1500	95/9376	0.592168421052632	ATP6V1G1/ATP6V0E1/CXCL8/TGFB1/ITGAL/ATP6V1E1/IFNG/ATP6V1H/IL15	-1.74350694255122
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1500	254/9376	0.738267716535433	CAMK4/CAMK1D/NFATC2/CALM1/CXCR4/GNAQ/PRKCB/PPP3CC/STIM1/PLCB1/PPP3CA/CAMK2D/ITPKB/ATP2B1/PRKCA/ATP2B4/PRKACB/MCOLN2/MCU/STIM2/PDGFD/ITPR1/PPP3CB/NFATC3/PHKB/VDAC1/F2R/CACNA1D/VDAC2/ATP2A3	-1.84547230663319
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1500	79/9376	0.553856540084388	GSTP1/GSTK1/HSD11B1/MGST3/ADH5/CBR3/MGST1	-1.73778112236017
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1500	54/9376	0.463012345679012	GZMB/TG/PRF1/FASLG	-1.72697100375347
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/1500	89/9376	0.561857677902622	ITGA4/CD44/THBS1/CD47/ITGB1/COL6A2/LAMB3/ITGB7	-1.81238684050407
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1500	23/9376	0.271768115942029	GLUD1	-1.52593682723449
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1500	23/9376	0.271768115942029	B4GALT1	-1.52593682723449
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1500	35/9376	0.357180952380952	GMDS/PMM2	-1.66266397555864
NA	NA	hsa04382	Cornified envelope formation	24/1500	217/9376	0.691317972350231	S100A6/S100A4/KRT6A/PPP2R5C/KRT24/PPP2R2B/S100A10/KRT10/SPRR3/KRT17/KRT14/PPP2R2D/KRT5/PPP2R5A/S100A8/PPP2R3A/PPP2R3C/SPTLC2/SPTLC1/S100A16/PPP2R5E/PPP2R2A/S100A12/LAMB3	-2.00768509938365
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1500	37/9376	0.337873873873874	ADSS2/GLUD1	-1.76104240185961
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/1500	37/9376	0.337873873873874	GMDS/PMM2	-1.76104240185961
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/1500	67/9376	0.466467661691542	GALM/PGK1/DLD/ADH5/G6PC3	-1.91260394875338
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	15/1500	154/9376	0.608831168831169	ADSS2/EPRS1/PTS/AK5/NME7/TPK1/GPHN/PMM2/PPCS/NME3/PANK2/DLD/GCH1/CMPK1/CTPS1	-2.13594692936513
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/1500	70/9376	0.44647619047619	GSTP1/GSTK1/HSD11B1/MGST3/MGST1	-2.02853365063461
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1500	99/9376	0.505104377104377	KRT24/KRT10/SELPLG/KRT17/KRT14/C1S/ITGAL/DEFA3	-2.16025911217184
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1500	73/9376	0.428127853881278	GSTP1/GSTK1/MGST3/ADH5/MGST1	-2.14055936933256
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/1500	65/9376	0.38465641025641	LIPC/AGPAT3/AGPAT4/AGK	-2.17247411103748
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/1500	75/9376	0.416711111111111	ACO2/MTR/PGK1/TALDO1/IDH2	-2.21323702621293
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1500	31/9376	0.201634408602151	TALDO1	-1.94299381957402
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1500	31/9376	0.201634408602151	DPYD	-1.94299381957402
NA	NA	hsa04081	Hormone signaling	22/1500	219/9376	0.627920852359208	GNG2/GNAQ/OPRM1/ESR2/GNB1/STAT5B/PLCB1/PIK3R1/IGF1R/PRKACB/GNG5/GNB5/PRL/PIK3CD/GNA13/PIK3CB/RAMP1/APPL1/ESR1/CSHL1/JAK2/VIPR2	-2.43141558395094
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	34/1500	323/9376	0.657964912280702	ZEB1/BCL2/RPS6KA5/PRKCB/SOS1/HDAC4/CDK6/RPTOR/PRKCE/PIK3R1/PDCD4/PRKCA/SOS2/NFKB1/CREBBP/CD44/MAPK1/RAF1/CDKN1B/MAP2K1/THBS1/PIK3CD/SLC7A1/BMPR2/PIK3CB/BRCA1/HDAC1/ABCB1/EFNA5/VIM/CDKN2A/KRAS/RASSF1/ABL1	-2.72994611920434
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1500	37/9376	0.168936936936937	ADH5	-2.21036028473311
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/1500	38/9376	0.164491228070175	PMM2	-2.25213433337826
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/1500	52/9376	0.240410256410256	IGF1R/PRKACB	-2.39694487041842
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/1500	298/9376	0.629261744966443	IL32/IL21R/CXCR4/RELL1/CXCL8/TGFBR2/CX3CR1/TNFSF8/XCL2/TGFB1/IL12RB2/PRL/CXCL14/CCR9/IL17RA/XCL1/ACVR2A/BMPR2/IL2RB/IL3RA/IFNGR1/IL4R/IL24/IFNG/OSM/FASLG/CCL28/CSHL1/IL7/IL15	-2.83830366716745
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/1500	76/9376	0.328982456140351	DBI/SCP2/ACSL5/CPT1A	-2.56317117763113
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1500	66/9376	0.284121212121212	HSD11B1/HSD17B12/HSD17B11	-2.5469184258386
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1500	41/9376	0.152455284552846	DLD	-2.37342657907333
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/1500	90/9376	0.347259259259259	PRKACB/ABCC4/ATP1B3/SLC4A4/ABCB1	-2.71535145253548
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1500	43/9376	0.145364341085271	ACAT1	-2.45122410226779
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/1500	103/9376	0.364116504854369	PRCP/ATP1B3/COL3A1/COL6A2/COL10A1/SLC36A4	-2.83181220444837
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1500	46/9376	0.135884057971014	EPRS1	-2.5638258701417
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/1500	50/9376	0.125013333333333	P4HA3	-2.7071800800876
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1500	68/9376	0.183843137254902	ALDH1A2/ADH5	-2.94766632414811
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	13/1500	183/9376	0.444036429872495	XRN1/CSNK2A1/NOP58/XRN2/PWP2/POP5/POP4/RPP38/RPP30/MDN1/WDR43/WDR75/WDR36	-3.31452778438632
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1500	86/9376	0.145364341085271	PLCB1/PRKACB	-3.47456781159809
NA	NA	hsa04082	Neuroactive ligand signaling	12/1500	199/9376	0.376924623115578	GNG2/GNAQ/OPRM1/GNB1/PRKCB/PLCB1/SLC18A2/PRKCA/PRKACB/GNG5/GNB5/TAC4	-3.87699441332128
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/1500	370/9376	0.287192792792793	P2RY8/GZMA/NR3C1/TSPO/OPRM1/UTS2/PGRMC2/PRL/F2R/P2RY10/S1PR5/NMUR1/TAC4/PTGDR/CSHL1/NPW/VIPR2	-6.10499604490893
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1500	449/9376	0.0696065330363771	CALM1/GNB1/NCALD/CAMK2D/PRKACB	-8.81689094945246