category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Organismal Systems Immune system hsa04062 Chemokine signaling pathway 13/161 193/9376 3.92263379783091 GNG10/PIK3R5/GNAQ/CXCL14/FOXO3/BRAF/XCL1/XCL2/MAP2K1/ELMO1/GNG5/GRK5/RAP1A 5.42265120895756 Organismal Systems Immune system hsa04666 Fc gamma R-mediated phagocytosis 9/161 98/9376 5.34820636329066 FCGR3A/FCGR3B/ASAP1/ARPC3/ACTR3/MYO10/MAP2K1/PLA2G6/GAB2 5.71935306991413 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 12/161 238/9376 2.93627016023801 RPL30/C7/RPL34/RPL39/TRAF3/RPL37/RPL41/RPS15A/FAU/RPL28/C1S/UBA52 3.99926111709232 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 7/161 99/9376 4.11769872639438 FCGR3A/FCGR3B/KRT24/FPR2/DEFA1/KRT14/C1S 4.12191347438873 Organismal Systems Nervous system hsa04730 Long-term depression 5/161 60/9376 4.85300207039337 GNAQ/BRAF/MAP2K1/IGF1R/GNA13 3.95740988354755 Cellular Processes Cell growth and death hsa04216 Ferroptosis 4/161 42/9376 5.54628808044957 FTH1/ACSL5/ACSL1/ATG7 3.90300048422552 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 10/161 232/9376 2.51017348468623 TMSB4X/ARPC3/CYRIB/ACTR3/ITGAD/C7/BRAF/RGCC/MAP2K1/GNA13 3.07860259375137 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 7/161 133/9376 3.06505393919582 FCGR3A/FCGR3B/FCER1G/IFNGR1/BRAF/KLRC1/MAP2K1 3.17030941406295 Cellular Processes Transport and catabolism hsa04144 Endocytosis 10/161 250/9376 2.32944099378882 ASAP1/ARPC3/ACTR3/IQSEC1/ARFGAP3/CAPZA1/SH3KBP1/CAPZA2/IGF1R/GRK5 2.81611084334844 Genetic Information Processing Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis 7/161 142/9376 2.87078995713411 ELOB/FBXW7/COP1/UBE2D3/UBE2B/UBE2H/UBA52 2.96910238173385 NA NA hsa04382 Cornified envelope formation 9/161 217/9376 2.41531900277643 S100A8/S100A9/S100A12/KRT6A/KRT24/S100A6/S100A4/KRT14/S100A11 2.78811755954363 Organismal Systems Nervous system hsa04725 Cholinergic synapse 6/161 115/9376 3.03840129624629 GNG10/PIK3R5/GNAQ/CREB5/MAP2K1/GNG5 2.90710401777571 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 6/161 115/9376 3.03840129624629 GNAQ/PDE4D/CREB5/BRAF/MAP2K1/GNA13 2.90710401777571 Genetic Information Processing Translation hsa03010 Ribosome 9/161 222/9376 2.36091992613732 RPL30/RPL34/RPL39/RPL37/RPL41/RPS15A/FAU/RPL28/UBA52 2.71240485172953 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 9/161 227/9376 2.30891728459244 ATP5F1E/NDUFB1/PTPRJ/FOXO3/BRAF/COX7A2/COX6B1/MAP2K1/MGST1 2.63869518117773 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 7/161 169/9376 2.41214304090558 EIF2AK3/GABARAP/MAP2K1/IGF1R/UBA52/RAB1A/ATG7 2.44857762900007 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 9/161 248/9376 2.11340412742937 TXN/LY96/ARPC3/RHOH/ACTR3/SNX18/MAP2K1/ELMO1/EXOC4 2.34877685161752 Organismal Systems Circulatory system hsa04270 Vascular smooth muscle contraction 6/161 134/9376 2.60758320200241 GNAQ/PRKCH/BRAF/MAP2K1/PLA2G6/GNA13 2.47738659335103 Organismal Systems Nervous system hsa04720 Long-term potentiation 4/161 67/9376 3.47677760266988 GNAQ/BRAF/MAP2K1/RAP1A 2.68920434549997 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 8/161 212/9376 2.197585843197 DOCK4/GNAQ/SIPA1L1/THBS1/BRAF/MAP2K1/IGF1R/RAP1A 2.33121833502004 Organismal Systems Immune system hsa04664 Fc epsilon RI signaling pathway 4/161 69/9376 3.37600144027365 FCER1G/MAP2K1/ALOX5AP/GAB2 2.6182872712379 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 4/161 70/9376 3.32777284826974 ELOB/BRAF/MAP2K1/RAP1A 2.58380063426914 Human Diseases Cancer: specific types hsa05219 Bladder cancer 3/161 41/9376 4.26117254961369 THBS1/BRAF/MAP2K1 2.76604634053302 Environmental Information Processing Signal transduction hsa04371 Apelin signaling pathway 6/161 140/9376 2.49582963620231 GNG10/PIK3R5/GNAQ/MAP2K1/GNG5/GNA13 2.35697564877239 Cellular Processes Transport and catabolism hsa04137 Mitophagy - animal 5/161 105/9376 2.77314404022479 EIF2AK3/GABARAP/FOXO3/TOMM7/UBA52 2.4150508647441 Human Diseases Cancer: specific types hsa05215 Prostate cancer 5/161 106/9376 2.74698230399625 CREB5/BRAF/ZEB1/MAP2K1/IGF1R 2.39085081556323 Metabolism Lipid metabolism hsa00061 Fatty acid biosynthesis 2/161 18/9376 6.47066942719117 ACSL5/ACSL1 3.07069096593297 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 5/161 110/9376 2.64709203839639 IFNGR1/ELOB/MAP2K1/PFKFB3/IGF1R 2.29677773269546 Human Diseases Cancer: specific types hsa05214 Glioma 4/161 76/9376 3.06505393919582 CAMK1D/BRAF/MAP2K1/IGF1R 2.38917316538226 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 7/161 187/9376 2.17995814926761 TXN/NAMPT/DEFA1/ANTXR2/GABARAP/TRAF3/CARD16 2.15429011148503 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 8/161 233/9376 1.99952016634233 DCN/TPM4/VCAN/THBS1/CAPZA1/COL6A3/CAPZA2/PDLIM1 2.04209559234768 Organismal Systems Nervous system hsa04726 Serotonergic synapse 5/161 115/9376 2.53200108020524 GNG10/GNAQ/BRAF/MAP2K1/GNG5 2.1848919070562 Human Diseases Drug resistance: antineoplastic hsa01521 EGFR tyrosine kinase inhibitor resistance 4/161 80/9376 2.91180124223603 FOXO3/BRAF/MAP2K1/IGF1R 2.26981562804918 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 7/161 196/9376 2.07985803016859 GNG10/PIK3R5/IFNGR1/TRAF3/MAP2K1/GNG5/UBA52 2.01940888947336 Human Diseases Infectious disease: parasitic hsa05144 Malaria 3/161 50/9376 3.49416149068323 HBB/THBS1/KLRB1 2.33729092359361 Organismal Systems Nervous system hsa04722 Neurotrophin signaling pathway 5/161 120/9376 2.42650103519669 FOXO3/BRAF/MAP2K1/IRAK2/RAP1A 2.07874849425783 Environmental Information Processing Signal transduction hsa04071 Sphingolipid signaling pathway 5/161 125/9376 2.32944099378882 GNAQ/FCER1G/MAP2K1/GAB2/GNA13 1.97779210410406 Organismal Systems Immune system hsa04611 Platelet activation 5/161 126/9376 2.31095336685399 PIK3R5/GNAQ/FCER1G/RAP1A/GNA13 1.95817975354046 Environmental Information Processing Signal transduction hsa04022 cGMP-PKG signaling pathway 6/161 166/9376 2.10491656065255 PIK3R5/GNAQ/CREB5/ATP2B1/MAP2K1/GNA13 1.89847384477427 Human Diseases Substance dependence hsa05032 Morphine addiction 4/161 91/9376 2.5598252678998 GNG10/PDE4D/GNG5/GRK5 1.97631697014973 Metabolism Global and overview maps hsa01212 Fatty acid metabolism 3/161 57/9376 3.06505393919582 ACSL5/ELOVL5/ACSL1 2.06697430720952 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 7/161 214/9376 1.90491670052824 B2M/GNG10/GNAQ/ELOB/MAP2K1/AP1G1/GNG5 1.76999179328611 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 5/161 133/9376 2.18932424228273 GABARAP/FOXO3/BRAF/MAP2K1/IGF1R 1.82587281141458 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 6/161 174/9376 2.00813878774898 EIF2AK3/CRYAB/SEC31A/UBE2D3/MARCHF6/SAR1B 1.77420884695501 Human Diseases Cancer: specific types hsa05213 Endometrial cancer 3/161 59/9376 2.96115380566375 FOXO3/BRAF/MAP2K1 1.99733319340005 Metabolism Glycan biosynthesis and metabolism hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 2/161 28/9376 4.15971606033718 B3GNT5/B4GALT1 2.21318963630358 Organismal Systems Endocrine system hsa04925 Aldosterone synthesis and secretion 4/161 98/9376 2.37698060590696 CAMK1D/GNAQ/CREB5/ATP2B1 1.81119238546125 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 5/161 138/9376 2.11000090017103 ATP5F1E/NDUFB1/COX7A2/COX6B1/ATP6V1G1 1.73630014561264 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 5/161 138/9376 2.11000090017103 ARPC3/GNAQ/ACTR3/MAP2K1/ELMO1 1.73630014561264 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 3/161 62/9376 2.81787216990583 CRYAB/FOXO3/IGF1R 1.8982000277075 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 5/161 139/9376 2.09482103757987 GNAQ/KRT24/CREB5/KRT14/MAP2K1 1.71884204600809 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 10/161 362/9376 1.6087299680862 GNG10/PIK3R5/THBS1/FOXO3/CREB5/PHLPP1/COL6A3/MAP2K1/IGF1R/GNG5 1.56124513347918 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 7/161 227/9376 1.79582455468301 B2M/GNG10/GNAQ/CREB5/MAP2K1/GNG5/GNA13 1.60433240680967 Organismal Systems Development and regeneration hsa04380 Osteoclast differentiation 5/161 142/9376 2.05056425509579 FCGR3A/FCGR3B/IFNGR1/MAP2K1/GAB2 1.66733460379901 Human Diseases Immune disease hsa05322 Systemic lupus erythematosus 5/161 143/9376 2.0362246449203 FCGR3A/FCGR3B/C7/H2AC20/C1S 1.65044639898387 Cellular Processes Transport and catabolism hsa04136 Autophagy - other 2/161 32/9376 3.63975155279503 GABARAP/ATG7 1.97707222404907 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 7/161 235/9376 1.73469010175763 ATP5F1E/NDUFB1/ACSL5/CREB5/COX7A2/COX6B1/ACSL1 1.50762097802583 Human Diseases Substance dependence hsa05034 Alcoholism 6/161 191/9376 1.82940392182368 GNG10/CREB5/BRAF/H2AC20/MAP2K1/GNG5 1.5307141410832 Environmental Information Processing Signal transduction hsa04072 Phospholipase D signaling pathway 5/161 149/9376 1.95422902163492 PIK3R5/FCER1G/MAP2K1/GAB2/GNA13 1.55190953429713 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 7/161 238/9376 1.71282426013884 GNG10/MAP2K1/PLA2G6/IGF1R/GAB2/GNG5/RAP1A 1.47229989153111 Organismal Systems Immune system hsa04613 Neutrophil extracellular trap formation 6/161 195/9376 1.79187768752986 FCGR3A/FCGR3B/FPR2/H2AC20/MAP2K1/ATG7 1.47700282031839 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 5/161 154/9376 1.89078002742599 PIK3R5/GNAQ/TPM4/CREB5/ATP2B1 1.47322533528503 Human Diseases Endocrine and metabolic disease hsa04934 Cushing syndrome 5/161 155/9376 1.87858144660389 GNAQ/CREB5/BRAF/MAP2K1/RAP1A 1.45783969850507 Human Diseases Cancer: specific types hsa05218 Melanoma 3/161 73/9376 2.39326129498851 BRAF/MAP2K1/IGF1R 1.57955007514536 Human Diseases Cancer: specific types hsa05223 Non-small cell lung cancer 3/161 73/9376 2.39326129498851 FOXO3/BRAF/MAP2K1 1.57955007514536 Human Diseases Infectious disease: parasitic hsa05143 African trypanosomiasis 2/161 37/9376 3.14789323484976 HBB/GNAQ 1.73027156571466 Human Diseases Cancer: specific types hsa05216 Thyroid cancer 2/161 37/9376 3.14789323484976 BRAF/MAP2K1 1.73027156571466 Cellular Processes Transport and catabolism hsa04148 Efferocytosis 5/161 157/9376 1.8546504727618 THBS1/VPS8/MAP2K1/ELMO1/PLA2G6 1.42740548859737 Environmental Information Processing Signal transduction hsa04150 mTOR signaling pathway 5/161 158/9376 1.8429121786304 LAMTOR5/BRAF/MAP2K1/IGF1R/ATP6V1G1 1.41235355266984 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 6/161 203/9376 1.72126181807056 THBS1/BRAF/COL6A3/MAP2K1/IGF1R/RAP1A 1.37320751316843 Organismal Systems Endocrine system hsa04918 Thyroid hormone synthesis 3/161 75/9376 2.32944099378882 TG/GNAQ/CREB5 1.52786781419136 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 2/161 38/9376 3.06505393919582 NAMPT/NNMT 1.68595962436698 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 6/161 204/9376 1.71282426013884 LUM/DCN/THBS1/BRAF/MAP2K1/IGF1R 1.36055605393709 Organismal Systems Endocrine system hsa03320 PPAR signaling pathway 3/161 76/9376 2.29879045439686 ACSL5/GK/ACSL1 1.50264128321414 Human Diseases Cancer: specific types hsa05220 Chronic myeloid leukemia 3/161 77/9376 2.26893603291119 BRAF/MAP2K1/GAB2 1.47780752964555 Metabolism Carbohydrate metabolism hsa00562 Inositol phosphate metabolism 3/161 78/9376 2.23984710941233 INPP5A/SYNJ1/IPMK 1.45335453695319 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 3/161 78/9376 2.23984710941233 ARPC3/ACTR3/ELMO1 1.45335453695319 Human Diseases Infectious disease: parasitic hsa05140 Leishmaniasis 3/161 78/9376 2.23984710941233 FCGR3A/FCGR3B/IFNGR1 1.45335453695319 Environmental Information Processing Signal transduction hsa04152 AMPK signaling pathway 4/161 122/9376 1.90937786376133 FOXO3/CREB5/PFKFB3/IGF1R 1.33631995139386 Metabolism Lipid metabolism hsa00071 Fatty acid degradation 2/161 43/9376 2.70865231835909 ACSL5/ACSL1 1.48432226339435 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 7/161 268/9376 1.52109020116807 TXN/ATP5F1E/NDUFB1/EIF2AK3/COX7A2/COX6B1/UBA52 1.14398333798125 Organismal Systems Endocrine system hsa04926 Relaxin signaling pathway 4/161 130/9376 1.79187768752986 GNG10/CREB5/MAP2K1/GNG5 1.20172125927901 Metabolism Metabolism of cofactors and vitamins hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 1/161 12/9376 4.85300207039337 COQ7 1.76526564552163 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 3/161 87/9376 2.00813878774898 TPM4/COX7A2/COX6B1 1.24866625656655 Environmental Information Processing Signal transduction hsa04024 cAMP signaling pathway 6/161 226/9376 1.54608915516957 PDE4D/CREB5/BRAF/ATP2B1/MAP2K1/RAP1A 1.09839394693026 Human Diseases Neurodegenerative disease hsa05020 Prion disease 7/161 275/9376 1.48237154150198 ATP5F1E/NDUFB1/EIF2AK3/C7/CREB5/COX7A2/COX6B1 1.07313503575689 Organismal Systems Nervous system hsa04728 Dopaminergic synapse 4/161 133/9376 1.75145939382618 GNG10/GNAQ/CREB5/GNG5 1.15365451009039 Organismal Systems Nervous system hsa04727 GABAergic synapse 3/161 89/9376 1.96301207341754 GNG10/GABARAP/GNG5 1.2065349839274 Human Diseases Infectious disease: bacterial hsa05152 Tuberculosis 5/161 181/9376 1.6087299680862 FCGR3A/FCGR3B/FCER1G/IFNGR1/IRAK2 1.09304743615549 Organismal Systems Aging hsa04211 Longevity regulating pathway 3/161 90/9376 1.94120082815735 FOXO3/CREB5/IGF1R 1.18587830002166 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 11/161 480/9376 1.33457556935818 DKK1/ATP5F1E/NDUFB1/GNAQ/EIF2AK3/BRAF/COX7A2/COX6B1/MAP2K1/UBA52/RAB1A 0.994645595201169 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 3/161 93/9376 1.87858144660389 PTPRJ/IGF1R/RAP1A 1.12546043791648 Metabolism Glycan biosynthesis and metabolism hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 1/161 14/9376 4.15971606033718 B4GALT1 1.56379083501247 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 3/161 94/9376 1.85859653759746 S100A8/S100A9/TRAF3 1.10581680094327 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 9/161 388/9376 1.35083562784145 DKK1/ATP5F1E/NDUFB1/GNAQ/EIF2AK3/BRAF/COX7A2/COX6B1/MAP2K1 0.932908236689192 Organismal Systems Digestive system hsa04979 Cholesterol metabolism 2/161 52/9376 2.23984710941233 VAPA/TSPO 1.18500335431239 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 4/161 142/9376 1.64045140407663 TXN/SUMO2/MGST1/SUMO1 1.01645071483159 Organismal Systems Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/161 53/9376 2.197585843197 GNAQ/ATP2B1 1.15562692689496 Organismal Systems Environmental adaptation hsa04713 Circadian entrainment 3/161 97/9376 1.80111417045527 GNG10/GNAQ/GNG5 1.04828796536267 Environmental Information Processing Signal transduction hsa04070 Phosphatidylinositol signaling system 3/161 98/9376 1.78273545443022 INPP5A/SYNJ1/IPMK 1.02956024857067 Human Diseases Drug resistance: antineoplastic hsa01522 Endocrine resistance 3/161 99/9376 1.76472802559759 BRAF/MAP2K1/IGF1R 1.011047900898 Organismal Systems Sensory system hsa04750 Inflammatory mediator regulation of TRP channels 3/161 99/9376 1.76472802559759 GNAQ/PRKCH/PLA2G6 1.011047900898 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 3/161 100/9376 1.74708074534161 CXCL14/XCL1/XCL2 0.992745849095128 Human Diseases Infectious disease: bacterial hsa05134 Legionellosis 2/161 56/9376 2.07985803016859 SAR1B/RAB1A 1.07128155135373 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 4/161 149/9376 1.56338321730793 GNG10/NDUFB1/GNAQ/GNG5 0.916257802456237 Metabolism Metabolism of other amino acids hsa00450 Selenocompound metabolism 1/161 17/9376 3.42564852027768 MARS1 1.32308734252028 Organismal Systems Digestive system hsa04972 Pancreatic secretion 3/161 102/9376 1.71282426013884 GNAQ/ATP2B1/RAP1A 0.956753189125514 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 5/161 200/9376 1.45590062111801 ARPC3/ACTR3/MYO10/RAB1A/GNA13 0.861408961817163 Metabolism Lipid metabolism hsa00564 Glycerophospholipid metabolism 3/161 104/9376 1.67988533205925 PGS1/PLA2G6/MBOAT2 0.921544977150409 Human Diseases Infectious disease: bacterial hsa05131 Shigellosis 6/161 253/9376 1.38109149829377 ARPC3/ACTR3/FOXO3/UBE2D3/ELMO1/UBA52 0.812216092355177 NA NA hsa04518 Integrin signaling 4/161 154/9376 1.51262402194079 ITGAD/THBS1/COL6A3/IGF1R 0.847808295366874 Organismal Systems Endocrine system hsa04921 Oxytocin signaling pathway 4/161 154/9376 1.51262402194079 CAMK1D/PIK3R5/GNAQ/MAP2K1 0.847808295366874 Cellular Processes Transport and catabolism hsa04145 Phagosome 4/161 155/9376 1.50286515728311 FCGR3A/FCGR3B/THBS1/ATP6V1G1 0.834409595281194 Organismal Systems Digestive system hsa04978 Mineral absorption 2/161 61/9376 1.90937786376133 FTH1/ATP2B1 0.941821873678788 Genetic Information Processing Translation hsa03013 Nucleocytoplasmic transport 3/161 108/9376 1.61766735679779 NUP98/SUMO2/SUMO1 0.853344554549608 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 4/161 157/9376 1.48372037820944 NDUFB1/EIF2AK3/COX7A2/COX6B1 0.807891816371803 Organismal Systems Immune system hsa04620 Toll-like receptor signaling pathway 3/161 109/9376 1.60282637187304 LY96/TRAF3/MAP2K1 0.836732844997386 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 3/161 110/9376 1.58825522303783 BRAF/MAP2K1/IGF1R 0.820289009915027 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 2/161 63/9376 1.84876269348319 PTGDS/PLA2G6 0.893434383286222 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 3/161 112/9376 1.55989352262644 LY96/PIK3R5/IFNGR1 0.78789090597884 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/161 21/9376 2.77314404022479 CSGALNACT1 1.07518370690195 Metabolism Metabolism of cofactors and vitamins hsa00770 Pantothenate and CoA biosynthesis 1/161 21/9376 2.77314404022479 VNN2 1.07518370690195 Human Diseases Infectious disease: viral hsa05161 Hepatitis B 4/161 163/9376 1.42910490416492 TRAF3/CREB5/BRAF/MAP2K1 0.730478858471281 Metabolism Lipid metabolism hsa00561 Glycerolipid metabolism 2/161 65/9376 1.79187768752986 GK/MBOAT2 0.846774025277085 Organismal Systems Endocrine system hsa04927 Cortisol synthesis and secretion 2/161 65/9376 1.79187768752986 GNAQ/CREB5 0.846774025277085 Organismal Systems Endocrine system hsa04929 GnRH secretion 2/161 65/9376 1.79187768752986 GNAQ/MAP2K1 0.846774025277085 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 3/161 116/9376 1.50610409081174 GNG10/GNAQ/GNG5 0.724960351512836 NA NA hsa04081 Hormone signaling 5/161 219/9376 1.32958960832695 GNG10/GNAQ/IGF1R/GNG5/GNA13 0.652333778153088 Human Diseases Cancer: specific types hsa05221 Acute myeloid leukemia 2/161 68/9376 1.71282426013884 BRAF/MAP2K1 0.779757655867297 Metabolism Glycan biosynthesis and metabolism hsa00515 Mannose type O-glycan biosynthesis 1/161 23/9376 2.53200108020524 B4GALT1 0.972295842635281 Metabolism Metabolism of terpenoids and polyketides hsa00900 Terpenoid backbone biosynthesis 1/161 23/9376 2.53200108020524 IDI1 0.972295842635281 Human Diseases Cancer: specific types hsa05225 Hepatocellular carcinoma 4/161 170/9376 1.37025940811107 BRAF/MAP2K1/MGST1/IGF1R 0.643940861667811 Environmental Information Processing Signal transduction hsa04668 TNF signaling pathway 3/161 119/9376 1.468135080119 TRAF3/CREB5/MAP2K1 0.67929816568096 Organismal Systems Endocrine system hsa04920 Adipocytokine signaling pathway 2/161 70/9376 1.66388642413487 ACSL5/ACSL1 0.736906165495224 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 2/161 70/9376 1.66388642413487 HSD11B1/MGST1 0.736906165495224 Metabolism Glycan biosynthesis and metabolism hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1/161 24/9376 2.42650103519669 HS3ST3B1 0.924860793617635 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 2/161 71/9376 1.64045140407663 FOXO3/MAP2K1 0.715991842289312 Human Diseases Infectious disease: viral hsa05164 Influenza A 4/161 173/9376 1.34649768427099 IFNGR1/NUP98/TRAF3/MAP2K1 0.608008405737085 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 3/161 122/9376 1.432033397821 GNAQ/CREB5/MAP2K1 0.634867937942464 Metabolism Lipid metabolism hsa00592 alpha-Linolenic acid metabolism 1/161 26/9376 2.23984710941233 PLA2G6 0.836758068629745 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 2/161 75/9376 1.55296066252588 THBS1/COP1 0.635493265766879 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 4/161 180/9376 1.29413388543823 B2M/IFNGR1/TRAF3/SRPK1 0.526662913830443 Metabolism Lipid metabolism hsa01040 Biosynthesis of unsaturated fatty acids 1/161 27/9376 2.15688980906372 ELOVL5 0.795686892778897 Organismal Systems Digestive system hsa04971 Gastric acid secretion 2/161 76/9376 1.53252696959791 GNAQ/KCNJ15 0.616109401046019 Human Diseases Cancer: specific types hsa05212 Pancreatic cancer 2/161 77/9376 1.51262402194079 BRAF/MAP2K1 0.597003804646713 Metabolism Lipid metabolism hsa00062 Fatty acid elongation 1/161 28/9376 2.07985803016859 ELOVL5 0.756375115804959 Organismal Systems Excretory system hsa04966 Collecting duct acid secretion 1/161 28/9376 2.07985803016859 ATP6V1G1 0.756375115804959 Human Diseases Infectious disease: bacterial hsa05133 Pertussis 2/161 78/9376 1.49323140627488 LY96/C1S 0.578168143987672 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 2/161 79/9376 1.47432974290432 HSD11B1/MGST1 0.559594444903692 Metabolism Lipid metabolism hsa00591 Linoleic acid metabolism 1/161 30/9376 1.94120082815735 PLA2G6 0.682465883871648 Organismal Systems Immune system hsa04612 Antigen processing and presentation 2/161 82/9376 1.42039084987123 B2M/KLRC1 0.505370344093654 Genetic Information Processing Chromosome hsa03083 Polycomb repressive complex 2/161 83/9376 1.4032777071017 UBE2D3/JARID2 0.487771250564964 Cellular Processes Transport and catabolism hsa04146 Peroxisome 2/161 83/9376 1.4032777071017 ACSL5/ACSL1 0.487771250564964 Cellular Processes Cell growth and death hsa04210 Apoptosis 3/161 137/9376 1.27524141995738 EIF2AK3/CTSW/MAP2K1 0.428955752352128 Organismal Systems Endocrine system hsa04910 Insulin signaling pathway 3/161 138/9376 1.26600054010262 BRAF/MAP2K1/INPP5A 0.416086848616119 Metabolism Carbohydrate metabolism hsa00052 Galactose metabolism 1/161 32/9376 1.81987577639752 B4GALT1 0.614055373116416 Human Diseases Immune disease hsa05310 Asthma 1/161 32/9376 1.81987577639752 FCER1G 0.614055373116416 Cellular Processes Cell motility hsa04814 Motor proteins 4/161 194/9376 1.20074278030352 TPM4/MYO10/CAPZA1/CAPZA2 0.373441915546637 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 5/161 250/9376 1.16472049689441 CTSW/LAMTOR5/AP1G1/CTBS/ATP6V1G1 0.348921975170999 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 6/161 308/9376 1.13446801645559 ATP5F1E/NDUFB1/GNAQ/CREB5/COX7A2/COX6B1 0.317168105134734 Genetic Information Processing Folding, sorting and degradation hsa04130 SNARE interactions in vesicular transport 1/161 33/9376 1.76472802559759 VTI1A 0.581663360917139 Environmental Information Processing Signal transduction hsa04012 ErbB signaling pathway 2/161 86/9376 1.35432615917955 BRAF/MAP2K1 0.436310326259177 Organismal Systems Endocrine system hsa04911 Insulin secretion 2/161 86/9376 1.35432615917955 GNAQ/CREB5 0.436310326259177 Human Diseases Cancer: specific types hsa05210 Colorectal cancer 2/161 87/9376 1.33875919183266 BRAF/MAP2K1 0.419582280816392 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 7/161 368/9376 1.10775047258979 ATP5F1E/NDUFB1/EIF2AK3/NUP98/COX7A2/COX6B1/RAB1A 0.278727494337647 NA NA hsa04082 Neuroactive ligand signaling 4/161 199/9376 1.17057336371297 GNG10/GNAQ/TAC3/GNG5 0.321468402931219 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 2/161 88/9376 1.32354601919819 C7/C1S 0.403057679221266 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 3/161 144/9376 1.21325051759834 MAP2K1/JARID2/IGF1R 0.340858672705928 Human Diseases Endocrine and metabolic disease hsa04936 Alcoholic liver disease 3/161 144/9376 1.21325051759834 LY96/TRAF3/FOXO3 0.340858672705928 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 2/161 89/9376 1.3086747156117 THBS1/COL6A3 0.386731229357988 Cellular Processes Cellular community - eukaryotes hsa04540 Gap junction 2/161 89/9376 1.3086747156117 GNAQ/MAP2K1 0.386731229357988 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 4/161 201/9376 1.15892586755663 DEFA1/KDM6A/ZEB1/IGF1R 0.301051287964133 Metabolism Carbohydrate metabolism hsa00051 Fructose and mannose metabolism 1/161 35/9376 1.66388642413487 PFKFB3 0.520094223668975 Human Diseases Cancer: overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 2/161 90/9376 1.29413388543823 IFNGR1/MAP2K1 0.370597838003542 Metabolism Carbohydrate metabolism hsa00500 Starch and sucrose metabolism 1/161 36/9376 1.61766735679779 GBE1 0.490776058660924 Organismal Systems Immune system hsa04662 B cell receptor signaling pathway 2/161 91/9376 1.2799126339499 IFITM1/MAP2K1 0.354652601172013 Human Diseases Cancer: specific types hsa05224 Breast cancer 3/161 148/9376 1.18045996306866 BRAF/MAP2K1/IGF1R 0.292488527011411 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 4/161 205/9376 1.13631267989699 ATP5F1E/NDUFB1/COX7A2/COX6B1 0.26082892192348 Metabolism Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism 1/161 37/9376 1.57394661742488 ADSS2 0.462352362890067 Organismal Systems Endocrine system hsa04912 GnRH signaling pathway 2/161 93/9376 1.25238763106926 GNAQ/MAP2K1 0.32330786734218 Organismal Systems Digestive system hsa04970 Salivary secretion 2/161 93/9376 1.25238763106926 GNAQ/ATP2B1 0.32330786734218 Human Diseases Infectious disease: viral hsa05160 Hepatitis C 3/161 156/9376 1.11992355470616 TRAF3/BRAF/MAP2K1 0.199642149989745 Cellular Processes Cell growth and death hsa04218 Cellular senescence 3/161 157/9376 1.11279028365708 ZFP36L1/FOXO3/MAP2K1 0.188378144146235 Genetic Information Processing Replication and repair hsa03440 Homologous recombination 1/161 41/9376 1.42039084987123 RAD51B 0.356565178379669 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 4/161 216/9376 1.07844490453186 LY96/EIF2AK3/TRAF3/RAP1A 0.154168193673489 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 6/161 333/9376 1.04929774494992 THBS1/TRAF3/CREB5/COL6A3/MAP2K1/ATP6V1G1 0.121072026411728 Organismal Systems Endocrine system hsa04916 Melanogenesis 2/161 101/9376 1.15318861078654 GNAQ/MAP2K1 0.204588449928355 Human Diseases Infectious disease: parasitic hsa05142 Chagas disease 2/161 103/9376 1.13079659892661 GNAQ/IFNGR1 0.176423258920071 Metabolism Glycan biosynthesis and metabolism hsa00513 Various types of N-glycan biosynthesis 1/161 44/9376 1.32354601919819 B4GALT1 0.284332131270793 Organismal Systems Excretory system hsa04962 Vasopressin-regulated water reabsorption 1/161 44/9376 1.32354601919819 CREB5 0.284332131270793 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 4/161 224/9376 1.03992901508429 B2M/CREB5/TSPO/MAP2K1 0.0799476141205319 Environmental Information Processing Signal transduction hsa04064 NF-kappa B signaling pathway 2/161 105/9376 1.10925761608991 LY96/TRAF3 0.148810640439778 Human Diseases Immune disease hsa05332 Graft-versus-host disease 1/161 45/9376 1.29413388543823 KLRC1 0.261419589596094 NA NA hsa04519 Cadherin signaling 7/161 404/9376 1.00904003443823 ARPC3/KRT6A/ACTR3/KRT24/KRT14/MAP2K1/IGF1R 0.0245508787514232 Metabolism Metabolism of cofactors and vitamins hsa00860 Porphyrin metabolism 1/161 46/9376 1.26600054010262 FTH1 0.239040516680639 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 2/161 107/9376 1.08852382887328 GNAQ/CREB5 0.121726894988301 Cellular Processes Cell growth and death hsa04217 Necroptosis 3/161 168/9376 1.03992901508429 FTH1/IFNGR1/H2AC20 0.0690258065105378 Cellular Processes Cellular community - eukaryotes hsa04530 Tight junction 3/161 170/9376 1.0276945560833 ARPC3/ACTR3/RAP1A 0.0481653022640814 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 2/161 110/9376 1.05883681535855 DCN/THBS1 0.0820446485248088 Metabolism Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis 1/161 49/9376 1.18849030295348 B4GALT1 0.174850537033239 Human Diseases Substance dependence hsa05030 Cocaine addiction 1/161 49/9376 1.18849030295348 CREB5 0.174850537033239 Metabolism Lipid metabolism hsa00565 Ether lipid metabolism 1/161 51/9376 1.14188284009256 PLA2G6 0.134289311583658 Human Diseases Infectious disease: bacterial hsa05110 Vibrio cholerae infection 1/161 51/9376 1.14188284009256 ATP6V1G1 0.134289311583658 Organismal Systems Endocrine system hsa04913 Ovarian steroidogenesis 1/161 52/9376 1.11992355470616 IGF1R 0.114618821553915 Organismal Systems Immune system hsa04670 Leukocyte transendothelial migration 2/161 116/9376 1.00406939387449 RHOH/RAP1A 0.00582913528512224 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 1/161 54/9376 1.07844490453186 TG 0.0764113681556681 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 1/161 55/9376 1.05883681535855 ACER3 0.0578429128444563 Metabolism Glycan biosynthesis and metabolism hsa00510 N-Glycan biosynthesis 1/161 56/9376 1.03992901508429 B4GALT1 0.0396118897378126 Environmental Information Processing Signal transduction hsa04340 Hedgehog signaling pathway 1/161 56/9376 1.03992901508429 GAS1 0.0396118897378126 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 1/161 59/9376 0.987051268554585 MGST1 -0.0131876097905527 Environmental Information Processing Signal transduction hsa04370 VEGF signaling pathway 1/161 60/9376 0.970600414078675 MAP2K1 -0.0301962495144413 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 2/161 128/9376 0.909937888198758 PDE4D/ADSS2 -0.135604501626053 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 1/161 66/9376 0.882364012798795 HSD11B1 -0.12676175261896 Human Diseases Immune disease hsa05321 Inflammatory bowel disease 1/161 66/9376 0.882364012798795 IFNGR1 -0.12676175261896 Cellular Processes Cell growth and death hsa04114 Oocyte meiosis 2/161 138/9376 0.844000360068413 MAP2K1/IGF1R -0.244019799882144 Metabolism Metabolism of cofactors and vitamins hsa00830 Retinol metabolism 1/161 68/9376 0.856412130069419 ALDH1A2 -0.157070609305919 Organismal Systems Endocrine system hsa04924 Renin secretion 1/161 69/9376 0.844000360068413 GNAQ -0.171907249140189 Human Diseases Substance dependence hsa05031 Amphetamine addiction 1/161 69/9376 0.844000360068413 CREB5 -0.171907249140189 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 1/161 70/9376 0.831943212067436 EIF4G3 -0.186541068891734 Human Diseases Infectious disease: bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection 1/161 71/9376 0.820225702038317 ATP6V1G1 -0.200978450471867 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 1/161 71/9376 0.820225702038317 MAP2K1 -0.200978450471867 Organismal Systems Immune system hsa04622 RIG-I-like receptor signaling pathway 1/161 72/9376 0.808833678398896 TRAF3 -0.215225481151764 Metabolism Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450 1/161 73/9376 0.797753764996171 MGST1 -0.229287971213467 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 3/161 217/9376 0.805106334258809 CREB5/MAP2K1/MGST1 -0.383932138712815 Human Diseases Drug resistance: antineoplastic hsa01524 Platinum drug resistance 1/161 75/9376 0.77648033126294 MGST1 -0.256881282657602 Human Diseases Cancer: specific types hsa05226 Gastric cancer 2/161 150/9376 0.77648033126294 BRAF/MAP2K1 -0.364758613280947 Metabolism Global and overview maps hsa01240 Biosynthesis of cofactors 2/161 154/9376 0.756312010970396 COQ7/ADSS2 -0.403025784469446 Organismal Systems Nervous system hsa04721 Synaptic vesicle cycle 1/161 79/9376 0.737164871452158 ATP6V1G1 -0.310081920986747 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 4/161 298/9376 0.781691608653966 IFNGR1/CXCL14/XCL1/XCL2 -0.506214264322064 Metabolism Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes 1/161 82/9376 0.710195424935616 MGST1 -0.348386835405824 NA NA hsa04517 IgSF CAM signaling 4/161 299/9376 0.779077255447766 ARPC3/ACTR3/MAP2K1/RAP1A -0.513163504972663 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 4/161 300/9376 0.77648033126294 BRAF/MAP2K1/IGF1R/RAP1A -0.520091834461932 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/161 85/9376 0.685129704055535 ADSS2 -0.385443593489563 Organismal Systems Immune system hsa04658 Th1 and Th2 cell differentiation 1/161 93/9376 0.626193815534629 IFNGR1 -0.478844703232121 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/161 93/9376 0.626193815534629 TRAF3 -0.478844703232121 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 1/161 95/9376 0.613010787839163 ATP6V1G1 -0.501088206491881 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 3/161 254/9376 0.687827065095124 CAMK1D/GNAQ/ATP2B1 -0.666680846586926 Human Diseases Cancer: overview hsa05231 Choline metabolism in cancer 1/161 99/9376 0.588242675199197 MAP2K1 -0.544384885847368 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 1/161 99/9376 0.588242675199197 TPM4 -0.544384885847368 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 1/161 103/9376 0.565398299463306 COL6A3 -0.586206743677708 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 1/161 103/9376 0.565398299463306 GNAQ -0.586206743677708 Organismal Systems Immune system hsa04625 C-type lectin receptor signaling pathway 1/161 105/9376 0.554628808044957 FCER1G -0.606602767661663 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 1/161 105/9376 0.554628808044957 TPM4 -0.606602767661663 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/161 109/9376 0.534275457291014 IFNGR1 -0.646433267999209 Human Diseases Endocrine and metabolic disease hsa04931 Insulin resistance 1/161 109/9376 0.534275457291014 CREB5 -0.646433267999209 Genetic Information Processing Chromosome hsa03082 ATP-dependent chromatin remodeling 1/161 117/9376 0.497743802091628 H2AC20 -0.722581935388574 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 2/161 205/9376 0.568156339948493 B2M/TRAF3 -0.826315764431065 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 2/161 205/9376 0.568156339948493 TRAF3/CREB5 -0.826315764431065 Organismal Systems Immune system hsa04660 T cell receptor signaling pathway 1/161 122/9376 0.477344465940332 MAP2K1 -0.768036088960327 Organismal Systems Endocrine system hsa04919 Thyroid hormone signaling pathway 1/161 122/9376 0.477344465940332 MAP2K1 -0.768036088960327 Human Diseases Infectious disease: viral hsa05162 Measles 1/161 136/9376 0.42820606503471 TRAF3 -0.887817946104451 Human Diseases Neurodegenerative disease hsa05017 Spinocerebellar ataxia 1/161 144/9376 0.404416839199448 GNAQ -0.951977458075133 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 3/161 323/9376 0.540891871622791 THBS1/ZEB1/MAP2K1 -1.10986687408509 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 1/161 160/9376 0.363975155279503 VCAN -1.07254061077711 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 1/161 168/9376 0.346643005028098 IFNGR1 -1.12946671542058 Environmental Information Processing Signal transduction hsa04310 Wnt signaling pathway 1/161 178/9376 0.327168678902924 DKK1 -1.19789955935054 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 3/161 370/9376 0.472183985227463 TAC3/FPR2/TSPO -1.3692046343429 Genetic Information Processing Translation hsa03008 Ribosome biogenesis in eukaryotes 1/161 183/9376 0.318229643960221 NOP10 -1.2310790339123