category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	61/1184	138/9376	3.50039169604387	ATP5F1E/NDUFB2/COX6C/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/ATP5ME/COX7A2/ATP6V0E1/ATP6V1G1/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/COX7B/NDUFA12/NDUFS6/COX17/ATP5PB/ATP5F1C/COX5B/COX8A/COX6A1/ATP5MC3/COX7A2L/ATP5MF/UQCRFS1/NDUFA2/UQCRQ/UQCRH/UQCR11/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/ATP5MC2/NDUFB9/ATP6V1E1/NDUFB10/NDUFAB1/COX5A/NDUFA5/CYCS/NDUFB3/ATP6V1F/COX7A1/PPA2/ATP6V0B/ATP5MC1/SDHB/NDUFS7/ATP5PO/NDUFB5/ATP5PD/NDUFB6/NDUFS4	11.2492904393541
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	90/1184	268/9376	2.65933844292053	ATP5F1E/CALM1/NDUFB2/COX6C/PSMA7/NDUFB1/COX7C/UBA52/MT-ND3/NDUFA4/COX6B1/RPS27A/NDUFB7/COX7A2/NDUFA1/COX4I1/UQCR10/UQCRB/GNAI2/ATP5PF/COX7B/NDUFA12/PSMB1/PSMD8/NDUFS6/PARK7/ATP5PB/ATP5F1C/COX5B/COX8A/COX6A1/ATP5MC3/COX7A2L/UBE2L3/UQCRFS1/CAMK2D/NDUFA2/MAPK8/UQCRQ/UQCRH/UQCR11/SEM1/VDAC3/TXN/BAX/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/PSMB7/COX5A/NDUFA5/PSMA3/VDAC2/SLC18A2/CYCS/PSMC5/PSMB6/NDUFB3/PSMD4/ITPR1/GNAI3/SLC39A11/SNCA/COX7A1/PSMB2/ATP5MC1/SDHB/NDUFS7/ATP5PO/PSMD14/MCU/TXN2/NDUFB5/ATP5PD/NDUFB6/UBE2J1/NDUFS4/CASP3/EIF2S1/UBE2G1	10.4774929792596
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	98/1184	308/9376	2.51965601965602	ATP5F1E/POLR2L/NDUFB2/COX6C/PSMA7/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/COX7B/NDUFA12/PLCB1/PSMB1/DCTN3/PSMD8/NDUFS6/ATP5PB/ATP5F1C/COX5B/COX8A/NRF1/COX6A1/ATP5MC3/COX7A2L/RCOR1/CREB1/UQCRFS1/AP2S1/NDUFA2/MAPK8/UQCRQ/GNAQ/UQCRH/UQCR11/SEM1/VDAC3/POLR2G/BAX/NDUFB4/ATP5F1D/ACTR10/MT-ATP8/NDUFV1/NDUFB11/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/DCTN4/PSMB7/COX5A/CLTA/NDUFA5/PSMA3/VDAC2/CYCS/WIPI1/PSMC5/PSMB6/NDUFB3/AP2M1/POLR2I/AMBRA1/PSMD4/ITPR1/POLR2K/HDAC1/POLR2J/CREBBP/AP2B1/HTT/COX7A1/PSMB2/ATP5MC1/SDHB/NDUFS7/ATP5PO/PSMD14/CLTB/NDUFB5/ATP5PD/NDUFB6/NDUFS4/CASP3/ATG13/POLR2F	10.3093531042495
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	88/1184	275/9376	2.53405405405405	ATP5F1E/CYBA/FYN/NDUFB2/COX6C/RAC2/PSMA7/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/PPP3CC/COX7B/NDUFA12/PSMB1/PSMD8/NDUFS6/ATP5PB/PPP3CA/ATP5F1C/COX5B/COX8A/COX6A1/ATP5MC3/COX7A2L/CREB1/UQCRFS1/NDUFA2/MAPK8/UQCRQ/UQCRH/UQCR11/SEM1/VDAC3/BAX/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/GSK3B/PSMB7/COX5A/NDUFA5/PSMA3/VDAC2/C7/CYCS/PSMC5/PSMB6/NDUFB3/PPP3CB/CSNK2A1/PSMD4/ITPR1/COX7A1/PSMB2/ATP5MC1/SDHB/NDUFS7/ATP5PO/PSMD14/MCU/NCAM1/NDUFB5/ATP5PD/ATF2/NDUFB6/NDUFS4/CASP3/EIF2S1	9.81587388764216
Genetic Information Processing	Translation	hsa03010	Ribosome	74/1184	222/9376	2.63963963963964	RPL37/RPS21/RPL37A/RPL39/RPS28/RPL34/RPS27/RPL27A/RPL36/RPL38/UBA52/RPS29/RPL35A/RPS27A/RPL3/RPL36AL/RPS4X/RPL30/RPS24/RPL7/RPL12/RPLP2/RPL21/RPL11/RPL6/RPS8/RPL35/RPS15/RPS23/RPS13/RPS15A/RPS11/RPS7/MRPL33/RPL32/MRPL54/RPL8/RPL9/RPL22/FAU/RPL28/RPL14/RPS6/RPL41/MRPL20/RPL27/RPL10/RPL24/MRPL52/RPL31/RPL5/RPL23/RACK1/RPS27L/RPL15/RPS3/MRPL51/RPS16/RPS20/MRPL42/MRPS10/RSL24D1/MRPL11/MRPL1/RPS10-NUDT3/MRPL47/MRPL41/MRPS21/MRPS33/MRPS31/MRPL43/MRPL27/DAP3/MRPS34	9.3990932851364
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	102/1184	368/9376	2.19491774383079	ACTB/ATP5F1E/PFN1/ACTG1/NDUFB2/COX6C/PSMA7/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/PPP3CC/COX7B/NDUFA12/PSMB1/DCTN3/PSMD8/NDUFS6/ATP5PB/PPP3CA/ATP5F1C/RAB1A/COX5B/RAB8A/COX8A/COX6A1/HNRNPA1/ATP5MC3/COX7A2L/UQCRFS1/NDUFA2/UQCRQ/UQCRH/UQCR11/SEM1/ANXA11/BAX/NDUFB4/ATP5F1D/ACTR10/MT-ATP8/NDUFV1/NDUFB11/NUP98/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/DCTN4/PSMB7/COX5A/NDUFA5/PSMA3/CYCS/WIPI1/PSMC5/SEC13/PSMB6/NDUFB3/PPP3CB/AMBRA1/PSMD4/COX7A1/PSMB2/BID/MATR3/ATP5MC1/NUP210/SDHB/SETX/NDUFS7/NUP153/ATP5PO/PSMD14/MCU/RAB5A/NDUFB5/ATP5PD/ANXA7/NDUFB6/NUP133/NDUFS4/MAP1LC3B/CASP3/ALYREF/EIF2S1/NCBP1/ATG13/CCS	8.89025562024952
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	68/1184	205/9376	2.62676334871457	ATP5F1E/CYBA/NDUFB2/COX6C/RAC2/PPP1CA/NDUFB1/COX7C/TGFB1/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/PRKCB/UQCRB/ATP5PF/COX7B/NDUFA12/PLCB1/NDUFS6/ATP5PB/ATP5F1C/COX5B/COX8A/COX6A1/ATP5MC3/COX7A2L/UQCRFS1/CAMK2D/NDUFA2/MAPK8/UQCRQ/UQCRH/UQCR11/VDAC3/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/ATP5MC2/NDUFB9/MPC1/NDUFB10/NDUFAB1/GSK3B/COX5A/PPP1CB/NDUFA5/VDAC2/TGFBR1/NDUFB3/COX7A1/ATP5MC1/SDHB/NDUFS7/ATP5PO/NDUFB5/GFPT1/ATP5PD/NDUFB6/NDUFS4/PDK3	8.95281232251339
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	73/1184	235/9376	2.45991949396205	ACTB/ATP5F1E/ACTG1/NDUFB2/COX6C/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/ATP5ME/COX7A2/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/COX7B/NDUFA12/NDUFS6/COX17/ATP5PB/ATP5F1C/COX5B/COX8A/COX6A1/ATP5MC3/COX7A2L/CREB1/ATP5MF/UQCRFS1/NDUFA2/UQCRQ/RPS6/UQCRH/UQCR11/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/ATP5MC2/NDUFB9/NDUFB10/ARID1B/NDUFAB1/COX14/COX5A/SOS1/SOS2/NDUFA5/SLC25A20/NDUFB3/SMARCC1/RPS6KA3/NDUFAF8/COX7A1/COA1/ATP5MC1/SDHB/NDUFAF2/NDUFS7/ATP5PO/COX19/COA3/RPTOR/NDUFB5/ZNF516/ATP5PD/ATF2/NDUFB6/NDUFS4	8.61653193354354
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	117/1184	480/9376	1.93023648648649	ATP5F1E/CALM1/NDUFB2/COX6C/PSMA7/NDUFB1/COX7C/UBA52/MT-ND3/NDUFA4/COX6B1/RPS27A/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/PRKCB/UQCRB/ATP5PF/PPP3CC/COX7B/NDUFA12/PLCB1/PSMB1/DCTN3/PSMD8/NDUFS6/DKK1/PARK7/ATP5PB/PPP3CA/ATP5F1C/RAB1A/COX5B/RAB8A/BRAF/COX8A/COX6A1/ATP5MC3/COX7A2L/UBE2L3/AXIN1/UQCRFS1/CAMK2D/NDUFA2/MAPK8/UQCRQ/GNAQ/UQCRH/UQCR11/SEM1/VDAC3/BAX/NDUFB4/ATP5F1D/ACTR10/MT-ATP8/NDUFV1/NDUFB11/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/DCTN4/GSK3B/PSMB7/COX5A/MAP2K2/NDUFA5/PSMA3/VDAC2/CYCS/WIPI1/PSMC5/PSMB6/NDUFB3/PPP3CB/AMBRA1/CSNK2A1/PSMD4/ITPR1/CAPN2/SNCA/FRAT2/HTT/COX7A1/PSMB2/BID/ATP5MC1/SDHB/DKK2/NDUFS7/ATP5PO/PSMD14/MCU/RAB5A/NDUFB5/FASLG/CSNK1A1/ATP5PD/NDUFB6/UBE2J1/HSD17B10/NDUFS4/MAP2K1/MAP1LC3B/CASP3/EIF2S1/ATG13/UBE2G1/CCS	7.95395480396015
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	100/1184	388/9376	2.04095848425745	ATP5F1E/CALM1/NDUFB2/COX6C/PSMA7/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/PPP3CC/COX7B/NDUFA12/PLCB1/PSMB1/PSMD8/NDUFS6/DKK1/ATP5PB/PPP3CA/ATP5F1C/COX5B/BRAF/COX8A/COX6A1/ATP5MC3/COX7A2L/AXIN1/UQCRFS1/NDUFA2/MAPK8/UQCRQ/GNAQ/UQCRH/UQCR11/SEM1/VDAC3/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/PSMA5/ATP5MC2/NDUFB9/NDUFB10/PSMD7/NDUFAB1/PSMA4/PSMD13/GSK3B/PSMB7/COX5A/MAP2K2/NDUFA5/PSMA3/VDAC2/CYCS/WIPI1/PSMC5/PSMB6/NDUFB3/PPP3CB/AMBRA1/CSNK2A1/PSMD4/ITPR1/CAPN2/SLC39A11/RTN4/SNCA/FRAT2/PSENEN/COX7A1/PSMB2/BID/ATP5MC1/SDHB/DKK2/NDUFS7/ATP5PO/PSMD14/MCU/NDUFB5/CSNK1A1/ATP5PD/NDUFB6/HSD17B10/NDUFS4/MAP2K1/CASP3/EIF2S1/ATG13	7.96130491815259
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	66/1184	227/9376	2.30241695439933	ATP5F1E/CYBA/NDUFB2/COX6C/NDUFB1/COX7C/MT-ND3/NDUFA4/COX6B1/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/UQCRB/ATP5PF/COX7B/NDUFA12/NDUFS6/ATP5PB/ATP5F1C/COX5B/BRAF/COX8A/COX6A1/MAP2K4/ATP5MC3/COX7A2L/ABL1/UQCRFS1/NDUFA2/MAPK8/UQCRQ/PTPRJ/UQCRH/ACP1/UQCR11/VDAC3/NDUFB4/ATP5F1D/MT-ATP8/NDUFV1/NDUFB11/ATP5MC2/NDUFB9/NDUFB10/NDUFAB1/COX5A/SOS1/MAP2K2/SOS2/NDUFA5/VDAC2/NDUFB3/COX7A1/ATP5MC1/SDHB/NDUFS7/ATP5PO/NDUFB5/ATP5PD/NDUFB6/NDUFS4/MGST1/MAP2K1	7.55166426105148
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	68/1184	253/9376	2.12840508492682	H3-3A/H3-3B/ACTB/MYL12A/PFN1/U2AF1/ACTG1/ARPC2/CAST/ARPC3/SEPTIN7/MYL12B/UBA52/ARPC5/ACTR3/RPS27A/RAC1/ELMO1/ARPC4/SEPTIN6/PRKCQ/PLCB1/CYTH1/DIAPH1/FNBP1/PXN/PYCARD/ATM/TLN1/ARPC5L/SEPTIN9/MAPK8/CAPNS1/PRKCE/RHOA/RBX1/BAX/ARF1/H3C4/WASF2/GSK3B/VCL/ACTR2/FBXW11/MYL11/CYCS/WIPI1/UBE2D2/HCLS1/CALCOCO2/ITPR1/CAPN2/UBE2V2/CUL1/RPS6KA5/FOXO1/ARF6/RIPK1/ATG5/H3C1/BTRC/CASP4/CSF2/MYL9/RPTOR/GLMN/RBCK1/MAP1LC3B	6.91708281445553
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	65/1184	238/9376	2.1627299568476	RPL37/RPS21/RPL37A/RPL39/JAK1/RPS28/RPL34/RPS27/RPL27A/RPL36/RPL38/UBA52/RPS29/RPL35A/RPS27A/RPL3/RPL36AL/RPS4X/RPL30/RPS24/PRKCB/RPL7/RPL12/RPLP2/RPL21/RPL11/RPL6/RPS8/RPL35/RPS15/RPS23/RPS13/RPS15A/RPS11/SYK/RPS7/RPL32/RPL8/RPL9/RPL22/FAU/MAPK8/RPL28/RPL14/RPS6/RPL41/STAT1/RPL27/RPL10/RPL24/RPL31/RPL5/RPL23/RPS27L/RPL15/RPS3/C7/RPS16/RPS20/TRAF3/RSL24D1/CSF2/RPS10-NUDT3/C1S/IRAK4	6.90729940026744
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	49/1184	157/9376	2.4715097262868	NDUFB2/COX6C/NDUFB1/COX7C/TGFB1/NDUFA4/COX6B1/NDUFB7/COX7A2/RAC1/NDUFA1/COX4I1/UQCR10/UQCRB/COX7B/NDUFA12/NDUFS6/COX5B/COX8A/COX6A1/COX7A2L/UQCRFS1/NDUFA2/MAPK8/UQCRQ/UQCRH/UQCR11/BAX/NDUFB4/NDUFV1/NDUFB11/NDUFB9/NDUFB10/NDUFAB1/GSK3B/COX5A/NDUFA5/CYCS/NDUFB3/COX7A1/BID/SDHB/NDUFS7/NDUFB5/FASLG/NDUFB6/NDUFS4/CASP3/EIF2S1	7.06866782159856
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	67/1184	250/9376	2.12227027027027	RAB11A/ARPC2/ARPC3/ARPC5/SH3KBP1/ACTR3/CAPZB/ARPC4/IL2RB/GRK5/CYTH1/IQSEC1/ARF5/CBLB/RAB8A/CAPZA1/ARPC5L/VPS4B/BIN1/AP2S1/RAB7A/CHMP2A/ACAP2/RHOA/CXCR2/SNX3/VPS37B/ARF1/SNX6/ACTR2/WIPF1/ASAP1/NEDD4/GRK6/CLTA/SMAP1/SH3GLB1/VPS29/TGFBR1/AP2M1/ARF6/ARAP1/RABEP1/SNF8/EPS15L1/DNM2/VTA1/VPS26A/RAB10/AP2B1/GBF1/CAPZA2/ARRB1/ARFGAP3/SPART/TSG101/PDCD6IP/CXCR1/CLTB/RAB5A/VPS36/RAB22A/ARFGEF1/WIPF2/RAB4A/MVB12A/ARRB2	6.8374434584011
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	40/1184	122/9376	2.59636685866194	CD247/FYN/MAP3K8/CARD11/NFATC2/VAV3/PPP2R2B/PPP3CC/PPP2R5C/PRKCQ/NFATC3/PPP3CA/CBLB/ITK/LCK/MAPK8/RHOA/CD3G/PAK2/VAV1/PPP2R3A/GRAP2/PPP2R5A/GSK3B/SOS1/MAP2K2/SOS2/PPP2R3C/LAT/PPP3CB/RASGRP1/PPP2R2D/PPP2R5E/NCK1/PAK1/CSF2/CD3E/DLG1/MAP2K1/LCP2	6.74705714341914
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	41/1184	133/9376	2.44117049380207	HCST/CD247/FCER1G/FYN/GZMB/TYROBP/PRF1/RAC2/NFATC2/SH2D1B/VAV3/RAC1/PRKCB/IFNGR1/LAT2/PPP3CC/FCGR3A/PPP3CA/ITGAL/BRAF/SYK/KLRD1/LCK/CD48/KLRC4-KLRK1/VAV1/ICAM2/SOS1/ITGB2/MAP2K2/SOS2/LAT/CD244/PPP3CB/BID/PAK1/CSF2/FASLG/MAP2K1/LCP2/CASP3	6.36357582701594
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	48/1184	174/9376	2.18452935694315	TMEM258/SSR4/PDIA3/DAD1/SEC61G/DNAJC1/MARCHF6/PDIA6/SEC61B/MAN1A1/MAPK8/SSR2/CALR/RBX1/BAX/SELENOS/DDOST/SEC31A/SEC62/KRTCAP2/OSTC/LMAN2/SEC24B/DERL2/PLAA/STUB1/DNAJC3/SEC13/UBE2D2/BCAP31/CAPN2/CUL1/RAD23A/CRYAB/FBXO6/UFD1/TRAM1/MAGT1/SIL1/ERP29/SEC23B/STT3B/HSP90B1/UBE2J1/RPN2/SAR1A/EIF2S1/UBE2G1	5.99578230160143
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	58/1184	232/9376	1.97972972972973	TMSB4X/CYRIB/ACTB/MYL12A/CFL1/PFN1/ACTG1/ARPC2/ARPC3/RAC2/MYL12B/PPP1CA/ARPC5/ACTR3/VAV3/MSN/RAC1/ARPC4/SSH2/PIP4K2A/BRK1/IQGAP2/PDGFD/DIAPH1/ITGAL/PXN/BRAF/ARPC5L/CYFIP2/ITGB7/CYRIA/ITGAM/RHOA/ITGAD/PAK2/PPP1R12A/VAV1/WASF2/ARHGEF7/VCL/ACTR2/SOS1/ITGB2/MAP2K2/PPP1CB/SOS2/MYL11/C7/ITGA4/GSN/FGD3/SSH1/GNA13/PAK1/MYL9/PPP1R12B/RRAS2/MAP2K1	5.74445310176397
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	41/1184	142/9376	2.28644842025124	ELOB/UBA52/RPS27A/UBE2Q1/UBE2M/ANAPC16/CBLB/COP1/PIAS1/UBE2L3/BIRC6/CUL3/ANAPC11/RBX1/UBE2B/FBXW7/RNF7/UBE2K/STUB1/WWP2/FBXW11/NEDD4/UBE2H/UBE2R2/UBE2D2/UBE4A/CUL1/PPIL2/UBE2E3/ELOC/BTRC/UBE2E1/UBR5/CDC27/CDC26/UBA2/UBE2J1/UBE2O/CUL2/HUWE1/UBE2G1	5.87229862410996
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	39/1184	138/9376	2.237955346651	ACTB/ACTG1/ARPC2/ARPC3/RAC2/NFATC2/ARPC5/ACTR3/VAV3/RAC1/ELMO1/ARPC4/NFATC3/FYB1/PXN/MAP2K4/PYCARD/ARPC5L/LCK/MAPK8/GNAQ/RHOA/PKN1/VAV1/WASF2/ARHGEF7/GSK3B/ACTR2/WIPF1/MAP2K2/LAT/ITGA4/WAS/RPS6KA3/ARF6/IRAK4/WIPF2/MAP2K1/LCP2	5.56957506596357
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	19/1184	46/9376	3.27085781433608	PSMA7/PSME4/PSMB1/PSMD8/POMP/SEM1/PSMA5/PSMD7/PSMA4/PSMD13/PSMB7/PSMA3/PSMC5/PSMB6/PSMD4/PSMB10/PSMB2/PSMD14/PSMF1	5.86941143799693
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	30/1184	98/9376	2.42415885273028	CFL1/ARPC2/ARPC3/LYN/RAC2/ARPC5/ACTR3/VAV3/RAC1/PRKCB/ARPC4/PLA2G6/FCGR3A/SYK/ARPC5L/BIN1/PRKCE/VAV1/WASF2/VASP/ACTR2/ASAP1/LAT/WAS/GSN/ARF6/DNM2/PAK1/PLPP1/MAP2K1	5.38779180246053
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	56/1184	248/9376	1.78814298169137	ACTB/MYL12A/PFN1/ACTG1/ARPC2/ARPC3/MYL12B/ARPC5/ACTR3/DYNLT1/RAC1/ELMO1/ARPC4/EXOC4/BRK1/CYTH1/DCTN3/MAP2K4/PYCARD/ARPC5L/CYFIP2/MAPK8/RAB7A/ABI1/RHOA/TXN/BAX/ARF1/ACTR10/PKN1/S100A10/RAB9A/DCTN4/ACTR2/MAP2K2/RHOH/RPS3/MYL11/CYCS/EXOC2/ARF6/DNM2/RIPK1/KPNA3/ARL8B/CASP4/PAK1/TXN2/MYL9/RAB5A/IRAK4/HSP90B1/VPS16/MAP2K1/CASP3/VPS41	4.78199981369254
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1184	31/9376	3.57628596338274	SRP14/SEC61G/SPCS2/SPCS1/SRP9/SEC11A/SEC61B/SEC11C/SEC62/SPCS3/IMMP1L/SRP72/GET3/TMEM208	5.46200104574748
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1184	116/9376	2.11626281453868	ACTB/MYL12A/CYBA/ACTG1/RAP1B/RAC2/MYL12B/VAV3/CD99/MSN/RAC1/PRKCB/GNAI2/ITGAL/ITK/PXN/TXK/ITGAM/RHOA/RAP1A/VAV1/VASP/PECAM1/VCL/ITGB2/RHOH/MYL11/ITGA4/GNAI3/MYL9/RASSF5	4.59892658127371
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	48/1184	214/9376	1.77620611265471	CD247/CFL1/CALM1/GNG2/ELOB/RAC2/NFATC2/PDIA3/RAC1/PRKCB/GNAI2/PPP3CC/NFATC3/PPP3CA/PXN/GNG5/ATM/GNB1/MAPK8/GNAQ/CALR/CD3G/RBX1/BAX/PAK2/RNF7/FBXW11/MAP2K2/SAMHD1/CYCS/PPP3CB/ITPR1/GNAI3/CUL1/RIPK1/BID/ELOC/BTRC/PAK1/APOBEC3C/GNB2/GNGT2/IRAK4/CD3E/FASLG/AP1G1/MAP2K1/CASP3	4.36671973628814
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	45/1184	200/9376	1.78175675675676	ACTB/ACTG1/ARPC2/FYN/ARPC3/ARPC5/ACTR3/RAC1/ARPC4/BRK1/MYO1F/CYTH1/TMED10/RAB1A/PYCARD/ARPC5L/ABL1/CYFIP2/MAPK8/ABI1/RHOA/BAX/ARF1/PAK2/WASF2/SEC24B/ACTR2/WIPF1/RPS3/CYCS/TMBIM6/HCLS1/MYO1H/ARF6/MYO1G/NCK1/RIPK1/GNA13/CASP4/PAK1/MYO5A/IRAK4/FASLG/WIPF2/CASP3	4.24841033357143
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	43/1184	193/9376	1.76431872286795	CX3CR1/GNG2/RAP1B/LYN/RAC2/VAV3/RAC1/ELMO1/PRKCB/GNAI2/GRK5/PLCB1/PIK3R5/ITK/PXN/GNG5/BRAF/DOCK2/FGR/GNB1/GNAQ/RHOA/CXCR2/RAP1A/STAT1/VAV1/GSK3B/SOS1/RASGRP2/SOS2/GRK6/CXCL14/WAS/GNAI3/ARRB1/PAK1/GNB2/CXCR1/CCL28/GNGT2/JAK3/MAP2K1/ARRB2	4.07875273660192
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	12/1184	30/9376	3.16756756756757	OGDH/IDH3B/SUCLG2/SUCLG1/MDH2/SDHB/IDH2/IDH3G/DLST/SUCLA2/ACO2/MDH1	4.52050444697846
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	25/1184	93/9376	2.12874164487068	ACTB/MYL12A/ACTG1/FYN/RAP1B/YES1/RAC2/MYL12B/RAC1/PTPRJ/RHOA/ACP1/RAP1A/WASF2/PDCD10/VCL/MYL11/TGFBR1/WAS/CSNK2A1/NLK/CREBBP/FER/CCM2/MYL9	4.15870740065095
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1184	126/9376	1.94830544830545	ACTB/MYL12A/FCER1G/ACTG1/FYN/RAP1B/LYN/MYL12B/PPP1CA/APBB1IP/GNAI2/PLCB1/PIK3R5/SYK/VAMP8/STIM1/TLN1/TBXAS1/GNAQ/RHOA/RAP1A/PPP1R12A/VASP/RASGRP2/PPP1CB/ITPR1/GNAI3/RASGRP1/GNA13/FERMT3/LCP2	4.07407640512383
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	32/1184	133/9376	1.90530380004064	CALM1/GNG2/PPP1CA/PRKCB/PPP2R2B/GNAI2/PPP3CC/PPP2R5C/PLCB1/PPP3CA/GNG5/CREB1/CAMK2D/GNB1/MAPK8/GNAQ/PPP2R3A/PPP2R5A/GSK3B/PPP1CB/PPP2R3C/SLC18A2/PPP3CB/ITPR1/GNAI3/PPP2R2D/PPP2R5E/ARRB1/GNB2/GNGT2/ATF2/ARRB2	3.99742390148844
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	30/1184	125/9376	1.90054054054054	FCER1G/FYN/RAC2/RAC1/PRKCB/PPP2R2B/GNAI2/PPP2R5C/PLCB1/S1PR5/MAPK8/GNAQ/PRKCE/RHOA/BAX/PPP2R3A/PPP2R5A/MAP2K2/PPP2R3C/GNAI3/PPP2R2D/S1PR1/PPP2R5E/BID/SPTLC1/GNA13/SPTLC2/ORMDL1/ORMDL2/MAP2K1	3.85327897029451
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	21/1184	78/9376	2.13201663201663	ACTB/ACTG1/ARPC2/ARPC3/ARPC5/ACTR3/RAC1/ELMO1/ARPC4/SEPTIN6/PXN/ARPC5L/SEPTIN9/RHOA/WASF2/VCL/ACTR2/CLTA/HCLS1/DNM2/CLTB	3.81655790335455
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	33/1184	149/9376	1.75385452566661	GNG2/NDUFB2/NDUFB1/MT-ND3/NDUFA4/NDUFB7/NDUFA1/PRKCB/GNAI2/NDUFA12/PLCB1/NDUFS6/GNG5/GNB1/NDUFA2/MAPK8/GNAQ/NDUFB4/NDUFV1/NDUFB11/NDUFB9/NDUFB10/NDUFAB1/NDUFA5/NDUFB3/ITPR1/GNAI3/NDUFS7/GNB2/GNGT2/NDUFB5/NDUFB6/NDUFS4	3.52628116859257
NA	NA	hsa04517	IgSF CAM signaling	57/1184	299/9376	1.50962668353973	ACTB/MYL12A/ACTG1/ARPC2/FYN/RAP1B/ARPC3/LYN/MYL12B/ARPC5/MYL6/ACTR3/SH2D1B/VAV3/MSN/RAC1/PRKCB/ARPC4/PRKCQ/ITGAL/PXN/MBP/ARPC5L/LCK/CD48/ABL1/MAPK8/CD96/ITGAM/RHOA/RAP1A/ICAM3/PAK2/VAV1/ICAM2/GSK3B/VCL/ACTR2/ITGB2/MAP2K2/ITGA4/MTSS1/CD244/FOXO1/RAPGEF2/ARF6/NCK1/SPTBN4/RASA1/CSK/PAK1/PLXNA4/MYL9/NCAM1/LY9/MAP2K1/LCP2	3.40473333755478
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	32/1184	144/9376	1.75975975975976	PSMA7/PRKCB/PLCB1/PSMB1/PSMD8/MAPK8/GNAQ/SEM1/VDAC3/PUM2/PSMA5/ATXN10/PSMD7/PSMA4/PSMD13/PSMB7/PSMA3/VDAC2/CYCS/WIPI1/PSMC5/PSMB6/PUM1/AMBRA1/PSMD4/ITPR1/RORA/PSMB2/PSMD14/MCU/OPA1/ATG13	3.49281958365789
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	49/1184	250/9376	1.55210810810811	CTSW/LITAF/SLC15A4/ATP6V0E1/ATP6V1G1/NPC1/ARSG/CD63/LAMTOR4/VAMP8/AP2S1/RAB7A/LAMTOR5/CTSC/CD164/DTNBP1/SUMF1/ATP6V1E1/CLTA/VPS29/AP3B1/WDR7/AP2M1/ATP6V1F/GUSB/MANBA/LAMTOR1/LAPTM5/BORCS7/OSBPL3/VPS26A/AP2B1/GNS/OSTM1/CTSS/ATP6V0B/ARL8B/OSBPL5/HGSNAT/CLTB/RPTOR/LAPTM4A/VPS16/AP1G1/BLOC1S2/SLC17A5/VPS41/LAMTOR2/AP5Z1	3.36372447182876
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	18/1184	67/9376	2.12747075433643	CALM1/RAP1B/PPP1CA/PRKCB/PPP3CC/PLCB1/PPP3CA/BRAF/CAMK2D/GNAQ/RAP1A/MAP2K2/PPP1CB/PPP3CB/ITPR1/RPS6KA3/CREBBP/MAP2K1	3.52093241864489
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/1184	203/9376	1.59938756490481	ACTB/MYL12A/ACTG1/FYN/RAP1B/RAC2/MYL12B/PPP1CA/VAV3/RAC1/PRKCB/PDGFD/DIAPH1/PXN/BRAF/TLN1/CCND3/MAPK8/ITGB7/RHOA/RAP1A/PAK2/PPP1R12A/VAV1/VASP/GSK3B/VCL/SOS1/PPP1CB/SOS2/MYL11/ITGA4/RAPGEF1/CAPN2/COL6A2/EMP1/PAK1/MYL9/COL6A1/PPP1R12B/MAP2K1	3.28221154281195
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	22/1184	91/9376	1.91446391446391	IFITM1/LYN/CARD11/RAC2/NFATC2/VAV3/RAC1/PRKCB/PPP3CC/NFATC3/PPP3CA/PIK3AP1/SYK/CD81/VAV1/GSK3B/SOS1/MAP2K2/SOS2/PPP3CB/CD79B/MAP2K1	3.33244378639568
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	18/1184	69/9376	2.06580493537015	FCER1G/FYN/LYN/RAC2/VAV3/RAC1/SYK/MAP2K4/MAPK8/VAV1/SOS1/MAP2K2/SOS2/LAT/ALOX5AP/CSF2/MAP2K1/LCP2	3.37803335069776
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	18/1184	70/9376	2.03629343629344	RAP1B/ELOB/TGFB1/RAC1/BRAF/ETS1/RBX1/RAP1A/PAK2/SOS1/MAP2K2/SOS2/RAPGEF1/CREBBP/ELOC/PAK1/MAP2K1/CUL2	3.30839046813748
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	22/1184	93/9376	1.8732926474862	CD247/STAT4/JAK1/IL12RB2/NFATC2/RUNX3/IFNGR1/IL2RB/PPP3CC/PRKCQ/NFATC3/PPP3CA/LCK/MAPK8/CD3G/STAT1/LAT/TBX21/PPP3CB/IL12RB1/CD3E/JAK3	3.21753752290322
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	26/1184	117/9376	1.75975975975976	ACTB/ACTG1/H2AZ1/H2AZ2/H2AJ/MACROH2A1/BRD7/H2AC20/ZNHIT1/MORF4L1/BICRAL/GATAD2A/H2AX/ARID2/BRD9/ARID1B/UCHL5/EPC1/SMARCC1/HDAC1/BCL7C/EPC2/H2AC17/YEATS4/INO80/ING3	3.14379120086686
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/1184	56/9376	2.121138996139	TMEM258/DAD1/B4GALT1/MAN1A1/MGAT4A/DDOST/KRTCAP2/OSTC/ST6GAL1/DPM3/ALG5/MAGT1/STT3B/DHRSX/RPN2	3.19898374737159
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/1184	109/9376	1.74361517480784	CD247/JAK1/NFATC2/TGFB1/IFNGR1/IL2RB/IL21R/PPP3CC/PRKCQ/NFATC3/PPP3CA/RUNX1/LCK/MAPK8/CD3G/STAT1/LAT/TGFBR1/TBX21/PPP3CB/IL12RB1/RORA/CD3E/JAK3	2.96864611010784
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/1184	196/9376	1.53530060672918	CALM1/GNG2/JAK1/LYN/NFATC2/UBA52/RPS27A/RAC1/IFNGR1/PPP3CC/NFATC3/PIK3R5/PPP3CA/GNG5/RB1/SYK/MAP2K4/CREB1/GNB1/MAPK8/CDK6/STAT1/BAX/GSK3B/MAP2K2/CYCS/PPP3CB/ITPR1/CREBBP/TRAF3/BID/CSF2/GNB2/GNGT2/ANGPT2/MAP2K1/MAP1LC3B/CASP3	2.87919413041461
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/1184	87/9376	1.82044113078596	COX6C/COX7C/COX6B1/COX7A2/COX4I1/UQCR10/UQCRB/TPM4/TPM3/COX7B/COX5B/COX8A/COX6A1/COX7A2L/UQCRFS1/UQCRQ/UQCRH/UQCR11/COX5A/COX7A1	2.9227326220486
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	42/1184	224/9376	1.4847972972973	JAK1/NFATC2/TGFB1/IL2RB/PPP3CC/NFATC3/ANAPC16/PPP3CA/ITGAL/RB1/MAP2K4/ETS1/ATM/TLN1/LCK/CREB1/CCND3/MAPK8/CALR/CD3G/VDAC3/ANAPC11/BAX/ITGB2/MAP2K2/VDAC2/TGFBR1/PPP3CB/RELB/CREBBP/CRTC3/CDC27/CRTC1/CSF2/CDC26/KAT2B/FDPS/CD3E/DLG1/ATF2/JAK3/MAP2K1	2.79185405088365
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	23/1184	105/9376	1.73462033462033	TOMM7/UBA52/RPS27A/ARIH1/MAPK8/RAB7A/MARCHF5/TBC1D15/GABARAPL2/TAX1BP1/AMBRA1/CALCOCO2/CSNK2A1/FIS1/USP15/TOMM20/PHB2/OPA1/RRAS2/RAB5A/MAP1LC3B/EIF2S1/HUWE1	2.877801417791
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	42/1184	227/9376	1.46517442552685	CALM1/GNG2/JAK1/RAC2/NFATC2/PDIA3/RAC1/PRKCB/GNAI2/PPP3CC/PLCB1/NFATC3/PPP3CA/PXN/GNG5/RB1/CREB1/AKAP13/GNB1/GNAQ/CALR/CDK6/RHOA/CXCR2/BAX/GSK3B/SOS1/MAP2K2/SOS2/CYCS/PPP3CB/ITPR1/GNAI3/RIPK1/BID/GNA13/GNB2/GNGT2/FASLG/ATF2/MAP2K1/CASP3	2.69717088106117
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/1184	138/9376	1.60673717195456	CALM1/PPP1CA/YWHAB/PPP3CC/YWHAZ/PPP2R5C/ANAPC16/PPP3CA/SPDYE2/CAMK2D/ANAPC11/RBX1/PPP2R5A/FBXW11/PPP1CB/PPP3CB/ITPR1/CUL1/RPS6KA3/SPDYE21/PPP2R5E/SPDYE18/BTRC/CDC27/SMC1B/SPDYE1/CDC26/MAP2K1	2.72971737926834
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	33/1184	170/9376	1.53720190779014	ACTB/MYL12A/ACTG1/ARPC2/ARPC3/MYL12B/ARPC5/MYL6/ACTR3/RAB8B/MSN/RAC1/PPP2R2B/ARPC4/LLGL2/RAB8A/RUNX1/ARHGEF18/ARPC5L/MAPK8/PRKCE/RHOA/RAP1A/VASP/ACTR2/NEDD4/HCLS1/WAS/PPP2R2D/RAPGEF2/MYL9/DLG1/SYMPK	2.68715698779039
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	25/1184	120/9376	1.64977477477477	ARHGDIB/CALM1/RAP1B/RAC1/BRAF/ABL1/CAMK2D/MAPK8/RHOA/MATK/RAP1A/BAX/ARHGDIA/GSK3B/SOS1/MAP2K2/SOS2/RAPGEF1/RPS6KA5/RPS6KA3/SH2B3/IRAK4/KIDINS220/FASLG/MAP2K1	2.7233804467758
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	43/1184	238/9376	1.43072904837611	PLAAT2/CALM1/GNG2/RAP1B/RAC2/RAC1/RASSF1/PRKCB/RASA2/PLA2G6/PDGFD/EFNA5/GNG5/ETS1/ABL1/GNB1/MAPK8/RHOA/RAP1A/PAK2/SOS1/MAP2K2/RASGRP2/SOS2/LAT/RALGAPA1/RASGRP1/EXOC2/ARF6/STK4/PLAAT3/RASA1/RASAL3/PAK1/GNB2/RASSF5/RRAS2/RAB5A/GNGT2/SHOC2/ANGPT2/FASLG/MAP2K1	2.55878373134236
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	39/1184	212/9376	1.45678225395207	ACTB/PFN1/SKAP1/ACTG1/CALM1/RAP1B/RAC2/APBB1IP/VAV3/EVL/RAC1/PRKCB/GNAI2/PLCB1/PDGFD/ITGAL/EFNA5/FYB1/BRAF/TLN1/GNAQ/SIPA1L1/ITGAM/RHOA/RAP1A/VAV1/VASP/ITGB2/MAP2K2/RASGRP2/LAT/SIPA1L3/RAPGEF1/GNAI3/RAPGEF2/RASSF5/ANGPT2/MAP2K1/LCP2	2.55741454562401
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	31/1184	163/9376	1.50605206433427	STAT4/JAK1/NFATC2/TGFB1/YWHAB/PRKCB/YWHAZ/NFATC3/RB1/BRAF/MAP2K4/CREB1/MAPK8/VDAC3/STAT1/BAX/SOS1/MAP2K2/SOS2/TGFBR1/CYCS/CREBBP/TRAF3/BID/SLC10A1/IRAK4/FASLG/ATF2/JAK3/MAP2K1/CASP3	2.47773573811014
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1184	205/9376	1.42926829268293	CD247/JAK1/LYN/RUNX3/PDIA3/RAC1/PSMD8/ITGAL/RB1/SYK/MAP2K4/CCND3/MAPK8/CALR/CDK6/CD3G/SEM1/STAT1/BAX/PSMD7/PSMD13/NEDD4/CYCS/PSMC5/PSMD4/HDAC1/RELB/CIR1/RIPK1/TRAF3/BID/PSMD14/NCOR2/IRAK4/CD3E/JAK3/CASP3	2.36245699992735
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/1184	90/9376	1.67177177177177	CD247/JAK1/NFATC2/IFNGR1/PPP3CC/PRKCQ/NFATC3/PPP3CA/LCK/CD3G/STAT1/EML4/MAP2K2/LAT/PPP3CB/CSNK2A1/RASGRP1/CD3E/MAP2K1	2.43441818331199
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/1184	116/9376	1.57013047530289	PCCA/OGDH/PGLS/IDH3B/SUCLG2/SUCLG1/FBP1/MDH2/TALDO1/SDHB/IDH2/ADH5/ME2/PGK1/IDNK/H6PD/IDH3G/ACAT1/DLST/ACAT2/SUCLA2/ACO2/MDH1	2.34889863167956
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1184	44/9376	1.97972972972973	TMEM258/DAD1/B4GALT1/MAN1A1/MGAT4A/DDOST/KRTCAP2/OSTC/MAGT1/STT3B/RPN2	2.47634858027606
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/1184	169/9376	1.45258276027507	UBA52/RPS27A/PRKCQ/RAB1A/RAB8A/VAMP8/BIRC6/MAPK8/RAB7A/ATG7/MAP2K2/GABARAPL2/SH3GLB1/TAX1BP1/WIPI1/AMBRA1/CALCOCO2/ITPR1/ATG10/ATG5/EPG5/MTMR3/UVRAG/RRAS2/RPTOR/VPS16/MAP2K1/MAP1LC3B/EIF2S1/VPS41/ATG13	2.2570896284996
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/1184	157/9376	1.46273024616974	CX3CR1/NFATC2/TGFB1/CD47/RAC1/ELMO1/PLA2G6/NFATC3/CREB1/UQCRFS1/CAMK2D/ATP8A1/RAB7A/CALR/ATP11B/PECAM1/MAP2K2/GPR132/HAVCR2/S1PR1/VPS8/BSG/RAB14/RAB5A/ANO5/VPS16/MAP2K1/CASP3/VPS41	2.22280990927198
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	29/1184	157/9376	1.46273024616974	CALM1/PPP1CA/NFATC2/TGFB1/PPP3CC/NFATC3/PPP3CA/RB1/ETS1/ATM/CCND3/CDK6/VDAC3/FBXW11/MAP2K2/PPP1CB/VDAC2/TGFBR1/PPP3CB/ITPR1/CAPN2/FOXO1/NBN/BTRC/MCU/LIN52/RASSF5/RRAS2/MAP2K1	2.22280990927198
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1184	34/9376	2.09618441971383	POLR2L/POLR1F/POLR3GL/POLR2G/POLR2I/POLR2K/POLR2J/POLR3C/POLR2F	2.43427517255088
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1184	34/9376	2.09618441971383	CRY1/CREB1/RBX1/FBXW11/NR1D2/CUL1/RORA/BHLHE40/BTRC	2.43427517255088
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1184	63/9376	1.75975975975976	POLR2L/CCNH/POLR2G/RBX1/GTF2H5/ERCC1/XPA/POLR2I/POLR2K/RAD23A/POLR2J/RPA1/MNAT1/POLR2F	2.30021419114448
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	32/1184	178/9376	1.42362587306408	RAC2/NFATC2/RAC1/PRKCB/PPP3CC/PLCB1/NFATC3/DKK1/PPP3CA/CTBP2/CCND3/AXIN1/CAMK2D/MAPK8/RHOA/RBX1/LGR6/CTNNBIP1/GSK3B/FBXW11/TBL1X/PPP3CB/CSNK2A1/NLK/CUL1/TLE1/CREBBP/FRAT2/BTRC/DKK2/SENP2/CSNK1A1	2.16926342072571
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1184	70/9376	1.6969111969112	ACTB/ACTG1/FYN/PRF1/RAC2/EIF4G3/RAC1/SNTB1/ITGAL/ABL1/SGCE/ITGB2/CYCS/BID/CASP3	2.22490491616548
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/1184	115/9376	1.51492361927145	PDE4D/PRKCB/GNAI2/NACA/PLCB1/MMP24/STK39/BRAF/CREB1/AKAP13/GNAQ/RHOA/PDE4A/ITPR1/GNAI3/OXSR1/ARRB1/GNA13/MMP25/ATF2/MAP2K1/ARRB2	2.1121721346809
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1184	53/9376	1.79296277409485	RAB11A/PRKCB/PLCB1/AP2S1/ATP2B4/GNAQ/ATP2B1/CLTA/AP2M1/DNM2/AP2B1/CLTB	2.20079408407733
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	34/1184	195/9376	1.38073458073458	H3-3A/H3-3B/ACTB/CYBA/ACTG1/H2AZ1/H2AZ2/RAC2/H4C3/H2AJ/MACROH2A1/SELPLG/RAC1/PRKCB/H2AC20/PLCB1/FCGR3A/ITGAL/SYK/ITGAM/VDAC3/H3C4/HDAC9/H2AX/ATG7/ITGB2/MAP2K2/VDAC2/HDAC1/H3C1/CASP4/H2AC17/MAP2K1/HDAC4	2.04249571248438
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	29/1184	166/9376	1.38342559426897	CALM1/PPP1CA/NFATC2/GNAI2/PPP3CC/PLCB1/NFATC3/PIK3R5/PPP3CA/CREB1/ATP2B4/GNAQ/PRKCE/RHOA/ATP2B1/VDAC3/PPP1R12A/VASP/MAP2K2/PPP1CB/VDAC2/PPP3CB/ITPR1/GNAI3/PDE5A/GNA13/MYL9/ATF2/MAP2K1	1.89483695357896
Genetic Information Processing	Transcription	hsa03040	Spliceosome	40/1184	243/9376	1.30352574797019	U2AF1/SRSF5/SNRPB2/CCDC12/LSM7/HNRNPA1/TXNL4A/SNRPD1/SRSF9/SF3B6/SNRPC/PCBP1/SNRPB/LSM6/SNRPF/MAGOH/LSM4/THOC7/SYF2/SNRPE/SNRPG/SF3B2/ZMAT2/AQR/SF3B5/SRSF4/LSM3/CWC15/CDC40/DHX8/CTNNBL1/SNRPD2/WBP11/BUD31/GPKOW/PPIE/SNU13/SNRPD3/ALYREF/NCBP1	1.82246192408798
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/1184	154/9376	1.38838188838189	ACTB/ACTG1/CALM1/PPP1CA/NFATC2/MYL6/CAMK1D/PRKCB/GNAI2/PPP3CC/PLCB1/NFATC3/PIK3R5/PPP3CA/CAMK2D/GNAQ/RHOA/PPP1R12A/CD38/MAP2K2/PPP1CB/PPP3CB/ITPR1/GNAI3/MYL9/PPP1R12B/MAP2K1	1.84745252998066
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1184	108/9376	1.46646646646647	SUMO2/SRRM1/SUMO1/NUP98/MAGOH/THOC7/SEC13/SUMO3/UPF3A/SAP18/XPO6/KPNA3/NUP210/NUP153/KPNA6/SENP2/XPO4/NUP133/ALYREF/NCBP1	1.8535564253951
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/1184	136/9376	1.39745627980922	JAK1/MSN/IL2RB/CBLB/CCND3/MAPK8/CDK6/CD3G/STAT1/BAX/RAB9A/RACK1/GSK3B/EIF3H/CYCS/CSNK2A1/TRAF3/BID/IRAK4/CD3E/FASLG/JAK3/CASP3/EIF2S1	1.77496318383986
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/1184	77/9376	1.54264654264654	TGFB1/BCR/RB1/BRAF/RUNX1/CTBP2/ABL1/CDK6/BAX/SOS1/MAP2K2/SOS2/TGFBR1/HDAC1/MAP2K1	1.81765224274462
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	19/1184	103/9376	1.46077145106271	PPP1CA/PPP2R2B/PPP2R5C/SRRM1/PPP2R3A/MAGOH/PPP2R5A/PPP1CB/PPP2R3C/UPF3A/PPP2R2D/SAP18/PPP2R5E/WDR33/RNGTT/SSU72/SYMPK/ALYREF/NCBP1	1.78755973201133
Human Diseases	Substance dependence	hsa05034	Alcoholism	32/1184	191/9376	1.32672987123249	H3-3A/H3-3B/H2AZ1/CALM1/GNG2/H2AZ2/H4C3/H2AJ/PPP1CA/MACROH2A1/GNAI2/H2AC20/GNG5/BRAF/CREB1/GNB1/H3C4/HDAC9/H2AX/SOS1/PPP1CB/SOS2/SLC18A2/GNAI3/HDAC1/H3C1/H2AC17/GNB2/GNGT2/ATF2/MAP2K1/HDAC4	1.73433289927124
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1184	71/9376	1.56147696992767	LYN/ATP6V0E1/ATP6V1G1/RAC1/MAP2K4/MAPK8/CXCR2/ATP6V1E1/ATP6V1F/ATP6V0B/CSK/PAK1/CXCR1/CASP3	1.80538342414007
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1184	23/9376	2.06580493537015	MVD/PDSS2/FDPS/ACAT1/FNTA/ACAT2	1.94550654145947
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	27/1184	158/9376	1.35323297981526	TFDP2/TGFB1/STAG1/YWHAB/YWHAZ/PPP2R5C/CDKN2D/ANAPC16/RB1/ATM/CCND3/ABL1/CDK6/CCNH/STAG2/ANAPC11/RBX1/PPP2R5A/GSK3B/CUL1/HDAC1/PPP2R5E/CREBBP/CDC27/SMC1B/CDC26/NIPBL	1.70230727098219
Human Diseases	Substance dependence	hsa05032	Morphine addiction	17/1184	91/9376	1.47935847935848	GNG2/PDE4D/PRKCB/GNAI2/GRK5/PDE7A/GNG5/GNB1/PDE4A/GRK6/OPRM1/GNAI3/PDE8A/ARRB1/GNB2/GNGT2/ARRB2	1.74685426152732
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1184	73/9376	1.51869677897075	RASSF1/PRKCB/RB1/BRAF/CDK6/BAX/EML4/SOS1/MAP2K2/SOS2/STK4/RASSF5/JAK3/MAP2K1	1.6913363713546
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1184	168/9376	1.31981981981982	H2AZ1/STAT4/JAK1/H2AZ2/H2AJ/MACROH2A1/PPIA/IFNGR1/H2AC20/PYCARD/VPS4B/CAMK2D/MAPK8/CHMP2A/VDAC3/FTH1/STAT1/BAX/H2AX/VDAC2/CAPN2/ZBP1/RIPK1/BID/H2AC17/FASLG/RBCK1/JAK3	1.5901711773872
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1184	87/9376	1.45635290462877	RAC2/TGFB1/RAC1/BRAF/AXIN1/MAPK8/RHOA/BAX/GSK3B/SOS1/MAP2K2/SOS2/TGFBR1/CYCS/MAP2K1/CASP3	1.62570777046172
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	30/1184	184/9376	1.29112808460635	MYL12A/CFL1/FYN/RAC2/MYL12B/NFATC2/RAC1/GNAI2/SSH2/PPP3CC/ABLIM1/NFATC3/PPP3CA/EFNA5/EPHA4/ABL1/CAMK2D/RHOA/PAK2/GSK3B/PPP3CB/GNAI3/NCK1/RGS3/FES/SSH1/RASA1/PAK1/PLXNA4/MYL9	1.51619312941363
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1184	31/9376	1.78814298169137	PCCA/GRHPR/MDH2/ACAT1/ACAT2/ACO2/MDH1	1.67094718962969
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1184	44/9376	1.61977886977887	CCNH/GTF2H5/GTF2A2/TAF12/TAF10/TAF3/TAF2/MNAT1/GTF2F2	1.56654276959156
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	30/1184	187/9376	1.27041479982656	CYBA/JAK1/CARD16/PLCB1/PYCARD/MAPK8/RHOA/VDAC3/STAT1/TXN/ERBIN/PKN1/GABARAPL2/VDAC2/ITPR1/RIPK1/ATG5/TRAF3/PSTPIP1/CASP4/TRPV2/CARD8/MCU/SUGT1/NEK7/TXN2/IRAK4/RBCK1/NAMPT/MAP1LC3B	1.41998465746653
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1184	32/9376	1.73226351351351	ATG7/GABARAPL2/WIPI1/ATG10/ATG5/RPTOR/ATG13	1.57740236250898
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	10/1184	51/9376	1.55272919978802	ACTB/ACTG1/ATP6V0E1/ATP6V1G1/SEC61G/SEC61B/ARF1/ATP6V1E1/ATP6V1F/ATP6V0B	1.50466421934755
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/1184	181/9376	1.26877706435717	FCER1G/CALM1/JAK1/TGFB1/CORO1A/IFNGR1/PPP3CC/FCGR3A/PPP3CA/SYK/CREB1/CAMK2D/MAPK8/RAB7A/ITGAM/RHOA/STAT1/BAX/ITGB2/CYCS/PPP3CB/CREBBP/BID/CTSS/ATP6V0B/FCGR2C/RAB5A/IRAK4/CASP3	1.38810444330219
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	23/1184	140/9376	1.30096525096525	CALM1/GNG2/GNAI2/PLCB1/PIK3R5/GNG5/NRF1/GNB1/GNAQ/RPS6/PRKCE/MAP2K2/KLF2/TGFBR1/ITPR1/GNAI3/GNA13/GNB2/RRAS2/GNGT2/MAP2K1/MAP1LC3B/HDAC4	1.36397034689696
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1184	33/9376	1.67977067977068	STX8/VTI1A/VAMP8/VAMP5/STX5/VAMP2/BET1L	1.48710879295956
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/1184	21/9376	1.88545688545689	CHSY3/UST/CHST11/CHST12/CSGALNACT2	1.54426450209062
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	14/1184	79/9376	1.40335271980842	ATP6V0E1/ATP6V1G1/NAPA/AP2S1/ATP6V1E1/VAMP2/CLTA/SLC18A2/AP2M1/ATP6V1F/DNM2/AP2B1/ATP6V0B/CLTB	1.36865389433538
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1184	86/9376	1.38120678818353	PRKCB/CBLB/BRAF/MAP2K4/ABL1/CAMK2D/MAPK8/PAK2/GSK3B/SOS1/MAP2K2/SOS2/NCK1/PAK1/MAP2K1	1.35010800340262
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	45/1184	300/9376	1.18783783783784	RAP1B/MAP3K8/RAC2/TGFB1/RAC1/PRKCB/PPP3CC/RASA2/NFATC3/PDGFD/TAOK3/PPP3CA/EFNA5/BRAF/MAP2K4/MAPK8/RAP1A/PAK2/SOS1/MAP2K2/RASGRP2/SOS2/TGFBR1/PPP5C/PPP3CB/NLK/RASGRP1/RPS6KA5/RPS6KA3/RAPGEF2/RELB/STK4/ARRB1/RASA1/MAX/PTPRR/PAK1/RRAS2/ANGPT2/IRAK4/FASLG/ATF2/MAP2K1/ARRB2/CASP3	1.25708018810135
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/1184	142/9376	1.2826417967263	CYBA/FYN/JAK1/TYROBP/NFATC2/TGFB1/RAC1/IFNGR1/PPP3CC/FCGR3A/PPP3CA/SYK/LCK/CREB1/MAPK8/STAT1/TGFBR1/PPP3CB/ITPR1/RELB/FCGR2C/MAP2K1/LCP2	1.29018545003747
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1184	60/9376	1.4518018018018	RAC2/NFATC2/RAC1/PRKCB/PPP3CC/PPP3CA/PXN/MAP2K2/PPP3CB/SH2D2A/MAP2K1	1.33467449507194
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1184	60/9376	1.4518018018018	LYN/PRKCB/GNAI2/PLCB1/BRAF/GNAQ/MAP2K2/ITPR1/GNAI3/GNA13/MAP2K1	1.33467449507194
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1184	47/9376	1.51638872915469	ACYP2/GRHPR/MDH2/ADH5/ME2/ACYP1/ACAT1/ACAT2/MDH1	1.34919478753608
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1184	122/9376	1.29818342933097	ACTB/ACTG1/NCOA1/PRKCB/PLCB1/STAT1/MED4/MED13L/GSK3B/MAP2K2/NCOR1/HDAC1/NCOA2/FOXO1/CREBBP/MED27/MED14/KAT2B/MED30/MAP2K1	1.26027462046103
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1184	28/9376	1.6969111969112	HACD4/HADHA/ELOVL1/HACD3/HSD17B12/ACAA2	1.4039887360756
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/1184	137/9376	1.27165121325705	CTSW/ACTB/ACTG1/GZMB/PRF1/ATM/MAPK8/CTSC/BAX/MAP2K2/CYCS/ITPR1/CAPN2/RIPK1/BID/CTSS/LMNB1/IL3RA/FASLG/MAP2K1/CASP3/EIF2S1	1.21765979501752
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/1184	173/9376	1.23590064052492	RAB11A/ACTB/ACTG1/JAK1/PRKCB/IFNGR1/PYCARD/CCND3/CDK6/STAT1/BAX/NUP98/MAP2K2/DNAJC3/CYCS/CALCOCO2/HNRNPUL1/CREBBP/TRAF3/BID/KPNA6/FDPS/IRAK4/FASLG/MAP2K1/CASP3/EIF2S1	1.19056737712699
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	17/1184	103/9376	1.30700603516138	CD247/TGFB1/IFNGR1/PPP2R2B/GNAI2/PLCB1/MAP2K4/MAPK8/GNAQ/CALR/CD3G/TGFBR1/GNAI3/PPP2R2D/IRAK4/CD3E/FASLG	1.19102783966587
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1184	42/9376	1.50836550836551	VDAC3/FTH1/PCBP1/ATG7/VDAC2/ATG5/GCLM/MAP1LC3B	1.2552589926297
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1184	69/9376	1.37720329024677	CALM1/PPP1CA/PRKCB/PPP3CC/PPP3CA/CREB1/CAMK2D/PPP1CB/SLC18A2/PPP3CB/HDAC1/ATF2	1.19553330272765
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	31/1184	204/9376	1.20336512983572	ACTB/ACTG1/LUM/DCN/PPP1CA/TGFB1/VAV3/MSN/RAC1/PRKCB/CD63/PXN/BRAF/CAMK2D/RPS6/RHOA/PPP1R12A/VAV1/SOS1/MAP2K2/PPP1CB/SOS2/HCLS1/ITPR1/PDCD4/PAK1/PPP1R12B/RRAS2/FASLG/MAP2K1/CASP3	1.11641603752235
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	24/1184	154/9376	1.23411723411723	CALM1/PPP1CA/CREM/TPM4/PPP2R2B/GNAI2/TPM3/PPP2R5C/PLCB1/PIK3R5/CREB1/CAMK2D/ATP2B4/GNAQ/ATP2B1/PPP2R3A/PPP2R5A/PPP1CB/PPP2R3C/GNAI3/RPS6KA5/PPP2R2D/PPP2R5E/ATF2	1.11364739041762
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1184	63/9376	1.38266838266838	SMYD3/CAMKMT/KMT2E/EHMT1/PHYKPL/COLGALT2/HADHA/ACAT1/DLST/ACAT2/KMT5B	1.15854944014731
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/1184	105/9376	1.28211068211068	FCER1G/CALM1/NFATC2/PPP3CC/NFATC3/PPP3CA/CBLB/SYK/PYCARD/MAPK8/RHOA/STAT1/PPP3CB/ITPR1/RELB/PAK1/RRAS2	1.10514027817061
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1184	50/9376	1.42540540540541	KLRB1/HBB/TGFB1/GYPC/ITGAL/CD81/KLRC4-KLRK1/PECAM1/ITGB2	1.14658648439968
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1184	134/9376	1.24102460669625	CALM1/PRKCH/PPP1CA/MYL6/PRKCB/PLA2G6/PRKCQ/PLCB1/BRAF/GNAQ/PRKCE/RHOA/PPP1R12A/MAP2K2/PPP1CB/RAMP1/ITPR1/GNA13/MYL9/PPP1R12B/MAP2K1	1.06831005869305
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/1184	156/9376	1.21829521829522	JAK1/YWHAB/PPP2R2B/YWHAZ/RB1/BRAF/PIAS1/CD81/CDK6/STAT1/BAX/GSK3B/SOS1/MAP2K2/SOS2/CYCS/PPP2R2D/RIPK1/TRAF3/BID/FASLG/MAP2K1/CASP3/EIF2S1	1.04521968155061
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1184	99/9376	1.27982527982528	RAC2/RAC1/PRKCB/PDGFD/GPCPD1/MAPK8/SLC44A2/WASF2/SOS1/MAP2K2/SOS2/CHKA/WAS/PLPP1/CHPT1/MAP2K1	1.06406285618455
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1184	78/9376	1.31981981981982	CNOT6L/CNOT2/PAN3/ZCCHC7/TENT4B/LSM7/C1D/DDX6/LSM6/LSM4/XRN1/LSM1/LSM3	1.07826230327403
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1184	51/9376	1.39745627980922	PLAAT2/PLA2G6/PLAAT3/PAFAH1B1/SELENOI/PEDS1/PLPP1/PLB1/CHPT1	1.08197331209076
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	32/1184	216/9376	1.17317317317317	CYBA/CALM1/RAP1B/LYN/NFATC2/VAV3/RAC1/PPP3CC/PLCB1/NFATC3/PPP3CA/MAP2K4/PYCARD/CAMK2D/MAPK8/MIB2/RHOA/RAP1A/BAX/VAV1/GSK3B/POU2F1/CYCS/PPP3CB/ITPR1/TRAF3/BID/IRAK4/HSP90B1/FASLG/CASP3/EIF2S1	0.978872823248611
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/1184	31/9376	1.53269398430689	PGLS/FBP1/RBKS/TALDO1/IDNK/H6PD	1.12936806732714
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/1184	130/9376	1.21829521829522	GNG2/TGFB1/GNAI2/PLCB1/GNG5/MAP2K4/CREB1/GNB1/MAPK8/SOS1/MAP2K2/SOS2/TGFBR1/GNAI3/ARRB1/GNB2/GNGT2/ATF2/MAP2K1/ARRB2	0.952808168816416
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/1184	32/9376	1.4847972972973	BIRC6/MAPK8/BAX/CYCS/BID/CASP3	1.04432405545577
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1184	139/9376	1.19638343379351	CALM1/NCOA1/GNAI2/KRT24/KRT10/PLCB1/ESR2/CREB1/KRT17/GNAQ/KRT14/SOS1/MAP2K2/SOS2/OPRM1/ITPR1/GNAI3/NCOA2/HSP90B1/ATF2/MAP2K1	0.886774702680233
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1184	33/9376	1.43980343980344	OGDH/IDH3B/IDH2/IDH3G/DLST/ACO2	0.962141472071424
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	20/1184	133/9376	1.1908148750254	TGFB1/CDKN2D/BRAF/ATM/MAPK8/SOS1/MAP2K2/GABARAPL2/SOS2/KLF2/TGFBR1/NLK/FOXO1/S1PR1/STK4/CREBBP/BCL6/C8orf44-SGK3/FASLG/MAP2K1	0.842554667451771
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1184	97/9376	1.22457509055447	CALM1/GNG2/PRKCB/GNAI2/PLCB1/GNG5/CREB1/CAMK2D/GNB1/GNAQ/ITPR1/GNAI3/RPS6KA5/GNB2/GNGT2	0.845207575287698
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	13/1184	83/9376	1.24031260175838	AUTS2/MBD5/JARID2/KDM2B/FOXK2/SFMBT2/UBE2D2/HDAC1/CREBBP/YAF2/USP16/MAX/L3MBTL4	0.835995886621222
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/1184	149/9376	1.1692363504444	FCER1G/FYN/PLCB1/CYTH1/PDGFD/PIK3R5/SYK/RHOA/CXCR2/ARF1/SOS1/MAP2K2/SOS2/ARF6/DNM2/AGPAT4/GNA13/CXCR1/PLPP1/RRAS2/AGPAT3/MAP2K1	0.791631455798093
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1184	76/9376	1.25035561877667	CALM1/CAMK1D/PRKCB/RB1/BRAF/CAMK2D/CDK6/BAX/SOS1/MAP2K2/SOS2/MAP2K1	0.833084745497898
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1184	27/9376	1.46646646646647	SCP2/HACD4/ELOVL1/HACD3/HSD17B12	0.922754662397408
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1184	41/9376	1.3520105471325	ATM/BABAM2/RAD51B/SEM1/RPA1/NBN/UIMC1	0.858730643927124
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1184	77/9376	1.23411723411723	JAK1/RAC2/TGFB1/RAC1/RB1/BRAF/MAPK8/CDK6/STAT1/BAX/TGFBR1/MAP2K1	0.784200547160842
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1184	158/9376	1.15275401984263	ATP6V1G1/PRKCB/LAMTOR4/BRAF/RPS6/RHOA/LAMTOR5/PRR5/ATP6V1E1/GSK3B/SOS1/MAP2K2/SOS2/NPRL3/SEC13/ATP6V1F/RPS6KA3/LAMTOR1/FNIP2/RPTOR/MAP2K1/PRR5L/LAMTOR2	0.736155153988908
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1184	56/9376	1.2726833976834	RAB1A/PYCARD/ITGAM/ARF1/ITGB2/CYCS/RAB1B/SAR1A/CASP3	0.778056744410222
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/1184	107/9376	1.18413740843647	CALM1/SIK1/PPP3CC/PLCB1/PPP3CA/CREB1/CAMK2D/GNAQ/PPP3CB/SIK2/ITPR1/FOXO1/FBP1/CREBBP/PPP4R3B/ATF2	0.728255866688961
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1184	49/9376	1.29288472145615	B4GALT1/FUT11/COLGALT2/ST6GAL1/GALNT10/GALNT3/GALNT11/GALNT2	0.781430370515229
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1184	122/9376	1.16836508639787	PRKCB/GNAI2/PLCB1/MAP2K4/CREB1/MAPK8/GNAQ/STAT1/GSK3B/SOS1/MAP2K2/SOS2/ITPR1/GNAI3/CREBBP/SOCS2/ATF2/MAP2K1	0.711596368165216
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/1184	78/9376	1.21829521829522	CFL1/CALM1/GNAI2/PYCARD/MAPK8/ITGAM/RHOA/ITGB2/GNAI3/C1S/IRAK4/CASP3	0.735975353263963
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/1184	78/9376	1.21829521829522	CYBA/JAK1/TGFB1/PRKCB/IFNGR1/FCGR3A/ITGAM/STAT1/ITGB2/ITGA4/FCGR2C/IRAK4	0.735975353263963
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/1184	115/9376	1.17062279670975	FYN/GNG2/PRKCB/GNAI2/PLCB1/PIK3R5/GNG5/CREB1/CAMK2D/GNB1/GNAQ/KCNQ5/ITPR1/GNAI3/GNB2/GNGT2/MAP2K1	0.699879949693444
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/1184	205/9376	1.12023731048121	JAK1/LYN/H4C3/YWHAB/RAC1/RASA2/YWHAZ/PXN/RB1/SYK/CREB1/CCND3/CDK6/RHOA/VDAC3/BAX/GTF2A2/HDAC9/GSN/HDAC1/UBR4/CREBBP/TRAF3/KAT2B/DLG1/ATF2/JAK3/CASP3/HDAC4	0.661720142485794
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1184	138/9376	1.14766940853897	CALM1/PPP1CA/CBLB/BRAF/PRKAR2A/INPP5A/MAPK8/RPS6/GSK3B/SOS1/MAP2K2/PPP1CB/SOS2/RAPGEF1/PRKAR1A/FOXO1/FBP1/SOCS2/RPTOR/MAP2K1	0.664366334399072
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/1184	57/9376	1.25035561877667	SCP2/HACD4/HADHA/ELOVL1/HACD3/HSD17B12/ACAT1/ACAA2/ACAT2	0.7207366923514
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1184	15/9376	1.58378378378378	ACP1/TPK1/THTPA	0.86020715693271
NA	NA	hsa04518	Integrin signaling	22/1184	154/9376	1.13127413127413	ACTB/ACTG1/RAC2/TGFB1/RAC1/PDGFD/ITGAL/PXN/TLN1/CCND3/ITGB7/ITGAM/ICAM3/ITGAD/ICAM2/GSK3B/VCL/ITGB2/ITGA4/COL6A2/COL6A1/FERMT3	0.624443964042265
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	15/1184	102/9376	1.16454689984102	RAB11A/RAP1B/RAC1/PRKCB/PLCB1/RAB8A/ATP2B4/GNAQ/RHOA/ATP2B1/RAP1A/CD38/ITPR1/RAB27B/SLC4A4	0.635217950194006
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1184	73/9376	1.19326175490559	PPIA/VPS4B/PIN1/SAMHD1/CREBBP/NUP153/APOBEC3C/TSG101/PDCD6IP/KAT2B/ELL2	0.630176720804498
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1184	44/9376	1.25982800982801	RAB11A/ARHGDIB/CREB1/ARHGDIA/DCTN4/VAMP2/RAB5A	0.656736958907067
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	10/1184	66/9376	1.1998361998362	STAT4/IL12RB2/TGFB1/IFNGR1/IL21R/STAT1/IL18RAP/TBX21/IL12RB1/RORA	0.619352374929205
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/1184	75/9376	1.16144144144144	GSTP1/ATM/BAX/ERCC1/XPA/CYCS/REV3L/BID/FASLG/MGST1/CASP3	0.533638744375662
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1184	99/9376	1.11984711984712	CALM1/PRKCH/PPP1CA/PRKCB/PLA2G6/PRKCQ/PLCB1/CAMK2D/MAPK8/GNAQ/PRKCE/PPP1CB/ITPR1/TRPV2	0.455730335478065
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1184	69/9376	1.14766940853897	CALM1/GNAI2/PPP3CC/PLCB1/PPP3CA/CREB1/GNAQ/PPP3CB/ITPR1/GNAI3	0.468033286737616
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/1184	32/9376	1.23733108108108	PCCA/SUCLG2/HADHA/SUCLG1/SUCLA2	0.511245748402564
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/1184	85/9376	1.11796502384738	ADSS2/GUK1/APRT/NT5E/NT5C2/ASMTL/HDDC2/DGUOK/ITPA/NME3/ADK/NT5C	0.41533450258216
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/1184	170/9376	1.07138314785374	ACTB/ACTG1/TGFB1/PRKCB/BRD7/GSTP1/RB1/BRAF/AXIN1/CDK6/BAX/ARID2/ARID1B/GSK3B/SOS1/MAP2K2/SOS2/TGFBR1/SMARCC1/FRAT2/CSNK1A1/MGST1/MAP2K1	0.357068211754331
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1184	194/9376	1.06129841181388	ACTB/MYL12A/ACTG1/MYL12B/MYL6/DYNLT1/TPM4/CAPZB/TPM3/MYO1F/DCTN3/CAPZA1/ACTR10/KIF2A/MYO9B/KIF13B/DCTN4/MYL11/KIFAP3/MYO1H/MYO1G/CAPZA2/HOOK3/MYO5A/MYL9/KIF13A	0.327980452580015
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1184	48/9376	1.15484234234234	PCCA/HADHA/ACAT1/ACAA2/AUH/HSD17B10/ACAT2	0.408867508619375
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1184	71/9376	1.11534069280548	ESR2/MAPK8/STAT1/GSK3B/SOS1/MAP2K2/SOS2/PRL/SOCS2/MAP2K1	0.370868594925045
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1184	56/9376	1.13127413127413	CUL3/GSK3B/FBXW11/CUL1/ARRB1/BTRC/CSNK1A1/ARRB2	0.374568910583328
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1184	110/9376	1.07985257985258	GNAI2/STK10/ANAPC16/BRAF/SPDYE2/MAPK8/ANAPC11/GNAI3/RPS6KA3/SPDYE21/SPDYE18/CDC27/SPDYE1/CDC26/MAP2K1	0.320262186227268
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1184	41/9376	1.15886618325643	RASSF1/RB1/BRAF/MAP2K2/RPS6KA5/MAP2K1	0.387554466641267
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1184	26/9376	1.21829521829522	PLAAT2/PLA2G6/PLAAT3/PLB1	0.423732337497828
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	21/1184	157/9376	1.05921845412291	ACTB/ACTG1/PPP1CA/TGFB1/YWHAB/RASSF1/PPP2R2B/YWHAZ/LLGL2/CCND3/AXIN1/GSK3B/ITGB2/FBXW11/PPP1CB/TGFBR1/PPP2R2D/BTRC/MOB1A/DLG1/LATS2	0.284466744341355
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1184	80/9376	1.08885135135135	JAK1/PRKCB/PDGFD/BRAF/RPS6/BAX/GSK3B/SOS1/MAP2K2/SOS2/MAP2K1	0.303408323656553
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	19/1184	142/9376	1.05957365816521	ACTB/CYBA/ACTG1/CALM1/RAC2/RAC1/SUMO2/GSTP1/MAP2K4/MAPK8/RHOA/SUMO1/TXN/PECAM1/KLF2/SUMO3/TXN2/HSP90B1/MGST1	0.271938078021366
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1184	19/9376	1.25035561877667	GUSB/GNS/HGSNAT	0.415271709905229
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/1184	65/9376	1.0964656964657	PRKCB/PLCB1/ESR2/GNAQ/MAP2K2/ITPR1/ARRB1/MAP2K1/ARRB2	0.2966866035014
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/1184	143/9376	1.05216405216405	H3-3A/H3-3B/H2AZ1/H2AZ2/H4C3/H2AJ/MACROH2A1/H2AC20/FCGR3A/SNRPD1/H3C4/SNRPB/H2AX/SSB/C7/H3C1/H2AC17/C1S/SNRPD3	0.238965078344082
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/1184	128/9376	1.05173141891892	ADSS2/PDE4D/GUK1/PDE7A/APRT/NT5E/NT5C2/PDE4A/HDDC2/PDE8A/PDE5A/DGUOK/ITPA/NME3/NUDT2/ADK/NT5C	0.224027835322723
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1184	12/9376	1.31981981981982	NPC1/NCAM1	0.421436175738667
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	43/1184	333/9376	1.02256310364418	JAK1/ATP6V0E1/ATP6V1G1/PPP2R2B/PPP2R5C/LLGL2/PXN/RB1/ATM/CREB1/CCND3/AXIN1/ITGB7/CDK6/STAT1/BAX/PPP2R3A/ATP6V1E1/PPP2R5A/GSK3B/SOS1/MAP2K2/SOS2/PPP2R3C/ITGA4/BCAP31/ATP6V1F/HDAC1/FOXO1/PPP2R2D/UBR4/PPP2R5E/COL6A2/CREBBP/TRAF3/ATP6V0B/TADA3/COL6A1/FASLG/DLG1/CSNK1A1/MAP2K1/CASP3	0.159379040248425
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1184	98/9376	1.05046883618312	CALM1/PRKCB/PIP4K2A/PLCB1/INPP5A/BPNT2/INPP4A/PI4KA/ITPR1/ITPKB/MTMR8/SYNJ1/MTMR3	0.190930654502378
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1184	59/9376	1.07375171781951	DPYD/NT5E/NT5C2/ASMTL/HDDC2/NME3/NUDT2/NT5C	0.216036242972035
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1184	59/9376	1.07375171781951	BRAF/AXIN1/BAX/GSK3B/SOS1/MAP2K2/SOS2/MAP2K1	0.216036242972035
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1184	28/9376	1.13127413127413	ATP6V0E1/ATP6V1G1/ATP6V1E1/ATP6V1F	0.264463252224767
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1184	83/9376	1.04949527841094	POLR2L/PYCARD/POLR3GL/PCBP1/SAMHD1/POLR2K/ZBP1/RIPK1/POLR3C/CASP3/POLR2F	0.172183434642853
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1184	115/9376	1.03290246768508	GNG2/PRKCB/GNAI2/PLCB1/GNG5/BRAF/GNB1/GNAQ/SLC18A2/ITPR1/GNAI3/GNB2/GNGT2/MAP2K1/CASP3	0.13496307569846
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1184	52/9376	1.06600831600832	LIPC/NPC1/STARD3NL/VDAC3/VDAC2/VAPA/OSBPL5	0.181453650678361
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/1184	68/9376	1.04809220985692	BRAF/RUNX1/ITGAM/SOS1/MAP2K2/SOS2/ZBTB16/CSF2/MAP2K1	0.151309961290922
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/1184	155/9376	1.02179598953792	ACTB/CYBA/ACTG1/ATP6V0E1/ATP6V1G1/CORO1A/RAC1/SEC61G/FCGR3A/SEC61B/RAB7A/CALR/ITGAM/ATP6V1E1/ITGB2/ATP6V1F/CTSS/ATP6V0B/FCGR2C/RAB5A	0.10402074177631
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1184	76/9376	1.04196301564723	ACTB/ACTG1/CALM1/PRKCB/GNAI2/PLCB1/CAMK2D/GNAQ/ITPR1/GNAI3	0.139636363591977
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1184	13/9376	1.21829521829522	XRCC5/XRCC6	0.299415931441363
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/1184	116/9376	1.0239981360671	GNG2/PRKCB/GNAI2/SLC38A1/PPP3CC/PLCB1/PPP3CA/GNG5/GNB1/GNAQ/PPP3CB/ITPR1/GNAI3/GNB2/GNGT2	0.0988706820854084
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1184	21/9376	1.13127413127413	DPYD/PPCS/VNN2	0.228946190716924
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/1184	362/9376	1.006271464835	GNG2/JAK1/YWHAB/RAC1/PPP2R2B/IL2RB/YWHAZ/PPP2R5C/PDGFD/PIK3R5/EFNA5/GNG5/PIK3AP1/SYK/CREB1/CCND3/GNB1/ITGB7/CDK6/RPS6/PKN1/PPP2R3A/PPP2R5A/GSK3B/SOS1/MAP2K2/SOS2/PPP2R3C/ITGA4/PRL/PPP2R2D/PPP2R5E/COL6A2/GNB2/IL3RA/COL6A1/GNGT2/C8orf44-SGK3/ANGPT2/RPTOR/HSP90B1/PHLPP1/FASLG/ATF2/JAK3/MAP2K1	0.0462627044544437
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1184	29/9376	1.09226467847158	RASSF1/PAK1/MOB1A/LATS2	0.189175490116932
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1184	37/9376	1.07012417823229	HBB/PRKCB/PLCB1/GNAQ/FASLG	0.162474413084494
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/1184	37/9376	1.07012417823229	TPM3/BRAF/BAX/MAP2K2/MAP2K1	0.162474413084494
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1184	93/9376	1.02179598953792	CALM1/PRKCB/PLCB1/MAP2K4/CAMK2D/MAPK8/GNAQ/SOS1/MAP2K2/SOS2/ITPR1/MAP2K1	0.0803045970774512
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1184	78/9376	1.01524601524602	PIP4K2A/PLCB1/INPP5A/INPP4A/PI4KA/INPP5K/ITPKB/MTMR8/SYNJ1/MTMR3	0.0514014532438322
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/1184	110/9376	1.00786240786241	ELOB/PRKCB/IFNGR1/CAMK2D/TIMP1/RPS6/RBX1/MAP2K2/CREBBP/ELOC/PGK1/ANGPT2/MAP2K1/CUL2	0.0315335075669925
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/1184	62/9376	1.02179598953792	CTBP2/HDAC1/CIR1/TLE1/CREBBP/PSENEN/NCOR2/KAT2B	0.0654592215478253
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1184	38/9376	1.04196301564723	NT5E/NT5C2/CD38/NAMPT/NT5C	0.0985367132531957
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1184	30/9376	1.05585585585586	PLAAT2/PLA2G6/PLAAT3/PLB1	0.116488477021058
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1184	14/9376	1.13127413127413	B4GALT1/CHST2	0.186863883348654
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/1184	226/9376	0.981104998804114	CALM1/RAP1B/PDE4D/RAC2/PPP1CA/VAV3/RAC1/GNAI2/BRAF/CREB1/CAMK2D/ATP2B4/MAPK8/RHOA/ATP2B1/RAP1A/PDE4A/PPP1R12A/VAV1/VIPR2/MAP2K2/PPP1CB/GNAI3/CREBBP/PAK1/MYL9/RRAS2/MAP2K1	-0.109309300176648
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/1184	105/9376	0.980437580437581	LYN/CARD11/PRKCB/PRKCQ/SYK/ATM/LCK/LAT/CSNK2A1/RELB/RIPK1/TRAF3/IRAK4	-0.076633814909641
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1184	48/9376	0.989864864864865	CD63/VPS4B/CD81/TSG101/SLC10A1/PDCD6IP	-0.0267622369278134
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/1184	89/9376	0.978742787731552	PRKCB/GNAI2/PLCB1/PDGFD/GNAQ/SOS1/MAP2K2/SOS2/ITPR1/GNAI3/MAP2K1	-0.0766002359581062
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1184	89/9376	0.978742787731552	GNG2/PRKCB/GNAI2/SLC38A1/GNG5/GNB1/GABARAPL2/GNAI3/GNB2/GNGT2/GPHN	-0.0766002359581062
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/1184	122/9376	0.973637571998228	RAB2A/PPP2R2B/PPP2R5C/RAB8A/CREB1/PPP2R3A/PPP2R5A/PPP2R3C/FOXO1/PPP2R2D/PPP2R5E/FBP1/RAB10/RAB14/RPTOR	-0.111421010278501
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/1184	106/9376	0.971188169301377	PDGFD/GSTP1/RB1/BRAF/CREB1/GSK3B/SOS1/MAP2K2/SOS2/FOXO1/CREBBP/HSP90B1/MAP2K1	-0.1134097615431
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1184	98/9376	0.969663541092113	CALM1/CAMK1D/PRKCB/PLCB1/CREB1/CAMK2D/ATP2B4/GNAQ/PRKCE/ATP2B1/ITPR1/ATF2	-0.114767060083396
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1184	49/9376	0.969663541092113	GNAI2/CREB1/SLC18A2/GNAI3/RGS9/ATF2	-0.0809391155900895
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/1184	75/9376	0.95027027027027	COP1/ATM/CCND3/CDK6/BAX/CYCS/BID/PPM1D/CASP3	-0.164379791794289
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1184	101/9376	0.940861653732941	CALM1/PRKCB/GNAI2/PLCB1/CREB1/CAMK2D/GNAQ/GSK3B/MAP2K2/GNAI3/CREBBP/MAP2K1	-0.227163954933103
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	12/1184	101/9376	0.940861653732941	TGFB1/RAC1/PRKCB/PLCB1/DIAPH1/MAPK8/PRKCE/STAT1/BAX/TGFBR1/FOXO1/CASP3	-0.227163954933103
NA	NA	hsa04519	Cadherin signaling	49/1184	404/9376	0.96046293818571	ACTB/ACTG1/ARPC2/ARPC3/RAC2/PPP1CA/ARPC5/ACTR3/YWHAB/VAV3/EVL/RAC1/KRT6A/ARPC4/KRT24/KRT10/BRK1/YWHAZ/MYO1F/TAOK3/ARPC5L/AXIN1/CYFIP2/MAPK8/KRT17/RHOA/ERBIN/KRT14/VAV1/VASP/GSK3B/VCL/ACTR2/MAP2K2/PPP1CB/TMC8/KRT5/MYO1H/MYO1G/CREBBP/PSENEN/CDH11/MOB1A/RRAS2/SHOC2/CSNK1A1/LATS2/MAP2K1/CDH23	-0.308828206553461
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	20/1184	168/9376	0.942728442728443	STAT4/JAK1/IL12RB2/IFNGR1/IL2RB/IL21R/PIAS1/CCND3/PTPN2/STAT1/SOS1/SOS2/PRL/IL12RB1/CREBBP/IL24/SOCS2/CSF2/IL3RA/JAK3	-0.284759023717225
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1184	43/9376	0.920804525455688	HADHA/ADH5/ACAT1/ACAA2/ACAT2	-0.19787479499373
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1184	26/9376	0.913721413721414	CUBN/BTD/PLB1	-0.167475161963427
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1184	35/9376	0.905019305019305	GMDS/FBP1/PMM2/ENOSF1	-0.214012527821605
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/1184	104/9376	0.913721413721414	PLAAT2/PLA2G6/GPCPD1/TAFAZZIN/CHKA/AGPAT4/PLAAT3/SELENOI/PLPP1/PLB1/AGPAT3/CHPT1	-0.33635624547338
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1184	27/9376	0.87987987987988	HADHA/ACAT1/ACAT2	-0.237619226368431
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1184	36/9376	0.87987987987988	GALNT10/GALNT3/GALNT11/GALNT2	-0.274511212259521
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1184	36/9376	0.87987987987988	RNASEH2C/RPA1/RNASEH2B/PRIM2	-0.274511212259521
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/1184	155/9376	0.919616390584133	RAP1B/GNAI2/PLCB1/RB1/BRAF/CREB1/AXIN1/CAMK2D/GNAQ/CDK6/RAP1A/GSK3B/MAP2K2/ITPR1/GNAI3/PDE8A/ATF2/MAP2K1	-0.383628495671032
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	21/1184	180/9376	0.923873873873874	JAK1/PPP1CA/PDIA3/IFNGR1/SRSF5/SYK/SRSF9/CALR/STAT1/BAX/PPP1CB/POU2F1/CYCS/SRSF4/TRAF3/BID/IRAK4/FASLG/CASP3/ALYREF/EIF2S1	-0.392045992629327
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1184	19/9376	0.833570412517781	OGDH/DLST	-0.276061307152908
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/1184	99/9376	0.87987987987988	SELPLG/KRT24/KRT10/FCGR3A/ITGAL/KRT17/ITGAM/KRT14/ITGB2/C1S/FCGR2C	-0.45676844558166
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/1184	201/9376	0.90614495092107	H3-3A/H3-3B/GZMB/KDM6A/IL2RB/RUNX1/ATM/ITGB7/ITGAM/KLF3/BAX/H3C4/FLI1/ETV6/SUPT3H/NCOR1/ZBTB16/HDAC1/FOXO1/BCL6/H3C1/MAX/CSF2	-0.511351048707813
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1184	29/9376	0.819198508853681	CALM1/GNB1/RGS9	-0.370707526087726
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1184	20/9376	0.791891891891892	GMDS/CYB5R4	-0.354181122449022
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1184	10/9376	0.791891891891892	BPNT2	-0.250310139329411
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1184	75/9376	0.844684684684685	TG/PRKCB/PLCB1/CREB1/GNAQ/ITPR1/HSP90B1/ATF2	-0.513389059879264
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1184	30/9376	0.791891891891892	MPPE1/PIGX/PIGK	-0.434013519223618
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/1184	103/9376	0.84570978745736	TGFB1/PRKCB/PLCB1/RAB7A/GNAQ/ITGAM/VCL/ITGB2/CSF2/RAB5A/CASP3	-0.598567837370538
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/1184	233/9376	0.883656188377218	ACTB/ACTG1/DCN/TPM4/CAPZB/TPM3/SNTB1/DIAPH1/CAPZA1/TLN1/ITGB7/SUN2/SGCE/TMOD3/VCL/MYL11/ITGA4/ANKRD23/PDLIM2/COL6A2/SPTBN4/CAPZA2/LMNB1/MYL9/COL6A1/VCAN	-0.683665093231624
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1184	42/9376	0.754182754182754	HADHA/ACAT1/DLST/ACAT2	-0.60697333567664
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1184	12/9376	0.65990990990991	COQ5	-0.448146919271399
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1184	23/9376	0.688601645123384	B4GALT1/CRPPA	-0.568422528651335
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1184	23/9376	0.688601645123384	SLC4A4/MDH1	-0.568422528651335
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/1184	62/9376	0.766346992153444	HDAC1/FOXO1/CRYAB/ATG5/EIF4EBP2/RPTOR	-0.701722854992686
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1184	99/9376	0.7998907998908	ESR2/RB1/BRAF/MAPK8/BAX/SOS1/MAP2K2/SOS2/NCOR1/MAP2K1	-0.760934705934901
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1184	63/9376	0.754182754182754	PLAAT2/PLA2G6/TBXAS1/PTGR3/PLAAT3/PLB1	-0.744225144847989
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/1184	44/9376	0.71990171990172	GZMB/PRF1/PTPRN2/FASLG	-0.707971757119675
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/1184	109/9376	0.799156955120258	JAK1/MAP3K8/RAC1/MAP2K4/MAPK8/STAT1/MAP2K2/RIPK1/TRAF3/IRAK4/MAP2K1	-0.801801716968108
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/1184	109/9376	0.799156955120258	PPP1CA/PRKCB/PRKCQ/CREB1/MAPK8/PRKCE/GSK3B/PPP1CB/RPS6KA3/FOXO1/GFPT1	-0.801801716968108
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/1184	73/9376	0.759348389485376	PDGFD/RB1/BRAF/CDK6/BAX/MAP2K2/MAP2K1	-0.784702813262306
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1184	45/9376	0.703903903903904	GZMB/PRF1/KLRD1/FASLG	-0.756904977439924
NA	NA	hsa04382	Cornified envelope formation	23/1184	217/9376	0.839332419977581	S100A4/S100A6/KRT6A/PPP2R2B/KRT24/KRT10/PPP2R5C/SPRR3/KRT17/S100A10/KRT14/S100A8/PPP2R3A/PPP2R5A/PPP2R3C/KRT5/PPP2R2D/PPP2R5E/ELOVL1/SPTLC1/S100A12/SPTLC2/S100A16	-0.910333672813036
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1184	65/9376	0.730977130977131	PLCB1/CREB1/GNAQ/ITPR1/PDE8A/ATF2	-0.827397553730198
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1184	93/9376	0.766346992153444	CALM1/PRKCB/PLCB1/ATP2B4/GNAQ/ATP2B1/CD38/VAMP2/ITPR1	-0.86086528067028
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1184	46/9376	0.688601645123384	EPRS1/FTH1/GUSB/BLVRB	-0.804861076879268
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1184	36/9376	0.65990990990991	GUSB/FGGY/CRPPA	-0.777209869709767
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/1184	112/9376	0.777750965250965	JAK1/TGFB1/IFNGR1/GNAI2/PIK3R5/MAPK8/STAT1/CYCS/GNAI3/IRAK4/CASP3	-0.899531009133213
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1184	37/9376	0.642074506939372	GMDS/PMM2/GFPT1	-0.829296483452105
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/1184	95/9376	0.750213371266003	TGFB1/ATP6V0E1/ATP6V1G1/ITGAL/ATP6V1E1/ITGB2/ATP6V1F/ATP6V0B/CSF2	-0.930250946204238
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1184	38/9376	0.625177809388336	LCK/CD3E/JAK3	-0.880149964142951
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1184	88/9376	0.71990171990172	A2M/ITGAM/ITGB2/C7/CLU/C1S/PROCR/F2RL2	-1.00359200384248
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1184	59/9376	0.671094823637197	GSTP1/GSTK1/IDH2/MGST1/GCLM	-0.96344113325417
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1184	28/9376	0.565637065637066	B4GALT1/ST3GAL4	-0.875062231626068
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1184	28/9376	0.565637065637066	PTS/GPHN	-0.875062231626068
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1184	39/9376	0.609147609147609	GZMB/PRF1/FASLG	-0.92983933581122
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1184	50/9376	0.633513513513514	TGFB1/ITGB7/ITGA4/CCL28	-0.9877835278564
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/1184	99/9376	0.71990171990172	ACTB/ACTG1/TGFB1/TPM4/TPM3/SNTB1/ITGB7/SGCE/ITGA4	-1.06510096628814
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1184	90/9376	0.703903903903904	CREB1/BAX/EHMT1/FOXO1/ATG5/RPTOR/ATF2/ATG13	-1.07301579291266
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/1184	61/9376	0.649091714665485	MT2A/ATP2B4/ATP2B1/ATOX1/FTH1	-1.04528237587923
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1184	100/9376	0.712702702702703	CD7/CD37/ITGAM/CD3G/CD38/ITGA4/CSF2/IL3RA/CD3E	-1.09803880392909
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1184	17/9376	0.465818759936407	SCP2	-0.838040267046689
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1184	17/9376	0.465818759936407	MARS1	-0.838040267046689
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1184	17/9376	0.465818759936407	CA5B	-0.838040267046689
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/1184	119/9376	0.732000908471497	MAP3K8/MAP2K4/CREB1/MAPK8/RPS6KA5/RIPK1/TRAF3/CSF2/ATF2/MAP2K1/CASP3	-1.1185056655297
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/1184	110/9376	0.71990171990172	EMP3/DCN/TGFB1/RHOA/RBX1/TGFBR1/NCOR1/CUL1/HDAC1/CREBBP	-1.12338120707411
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1184	72/9376	0.65990990990991	RNF125/PIN1/MAPK8/RIPK1/ATG5/TRAF3	-1.10126514011645
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	14/1184	148/9376	0.749086924762601	NCOA1/ESR2/RB1/BRAF/AXIN1/CDK6/BAX/GSK3B/SOS1/MAP2K2/SOS2/FRAT2/CSNK1A1/MAP2K1	-1.16967949234002
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1184	18/9376	0.43993993993994	MANBA	-0.904161170834313
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1184	31/9376	0.510897994768962	DPYD/HADHA	-1.03694842188302
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/1184	160/9376	0.742398648648649	CD99/SELPLG/ITGAL/SPN/ITGB7/ITGAM/ICAM3/GLG1/SELL/PECAM1/ICAM2/ITGB2/ITGA4/NCAM1/VCAN	-1.24940549829271
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1184	94/9376	0.673950546290972	MAPK8/S100A8/GSK3B/TRAF3/USP25/CSF2/HSP90B1/CASP3	-1.20779475479915
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1184	43/9376	0.552482715273413	PLPP1/ACAT1/ACAT2	-1.11814963520267
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1184	54/9376	0.586586586586587	ERCC1/REV3L/RPA1/FANCC	-1.15822627154049
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1184	54/9376	0.586586586586587	GZMB/PRF1/TG/FASLG	-1.15822627154049
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1184	75/9376	0.633513513513514	IDH3B/TALDO1/IDH2/PGK1/IDH3G/ACO2	-1.21140759604922
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1184	32/9376	0.494932432432432	B4GALT1/GALM	-1.08798917275706
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/1184	65/9376	0.609147609147609	LIPC/AGK/AGPAT4/PLPP1/AGPAT3	-1.2020922728074
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/1184	105/9376	0.678764478764479	ACTB/ACTG1/TGFB1/TPM4/TPM3/SNTB1/ITGB7/SGCE/ITGA4	-1.2584079079899
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/1184	44/9376	0.53992628992629	NEIL1/TDG/ADPRS	-1.16287466246192
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1184	55/9376	0.575921375921376	SPTLC1/SPTLC2/PLPP1/ACER3	-1.19912094952813
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1184	86/9376	0.644563167818982	PRKCB/PLCB1/CREB1/CAMK2D/GNAQ/VAMP2/ATF2	-1.25883936673402
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1184	20/9376	0.395945945945946	EBP	-1.02804520606956
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/1184	47/9376	0.505462909718229	MAPK8/PRKCE/SOCS2	-1.29210191233967
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/1184	100/9376	0.633513513513514	CX3CR1/IL2RB/CXCR2/CXCL14/IL18RAP/IL24/CXCR1/CCL28	-1.40069672448527
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/1184	59/9376	0.536875858909757	PLAAT2/GNAI2/GNAI3/PLAAT3	-1.35660025866291
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/1184	150/9376	0.686306306306306	TGFB1/RB1/BRAF/AXIN1/BAX/GSK3B/SOS1/MAP2K2/SOS2/TGFBR1/FRAT2/CSNK1A1/MAP2K1	-1.47235050609978
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/1184	217/9376	0.729854278241375	PRKCB/GNAI2/ESR2/RB1/CREB1/CCND3/SOS1/MAP2K2/SOS2/GNAI3/RPS6KA3/BCL6/ARRB1/KPNA3/KPNA6/HSP90B1/ATF2/MGST1/MAP2K1/ARRB2	-1.53063080335773
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1184	23/9376	0.344300822561692	RPA1	-1.19690479617904
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1184	23/9376	0.344300822561692	ATP6AP2	-1.19690479617904
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/1184	82/9376	0.579433091628214	DPYD/GSTP1/GUSB/ITPA/NME3/MGST1	-1.45414330340871
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1184	37/9376	0.428049671292915	ADSS2/GFPT1	-1.32518193172041
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/1184	93/9376	0.59604766056379	RB1/CDK6/BAX/CYCS/TRAF3/MAX/CASP3	-1.48831186583543
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1184	38/9376	0.41678520625889	PMM2/GFPT1	-1.36949330284102
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/1184	86/9376	0.552482715273413	ACTB/ACTG1/SNTB1/ITGB7/SGCE/ITGA4	-1.5849577880011
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1184	254/9376	0.717067461161949	CALM1/NFATC2/CAMK1D/PRKCB/PPP3CC/PLCB1/NFATC3/PDGFD/PPP3CA/STIM1/CAMK2D/ATP2B4/GNAQ/ATP2B1/VDAC3/ORAI2/CD38/VDAC2/PPP3CB/ITPR1/STIM2/ITPKB/MCU	-1.73788581560795
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/1184	54/9376	0.43993993993994	MDH2/GCLM/MDH1	-1.56907408941139
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1184	67/9376	0.472771278741428	FBP1/ADH5/PGK1/GALM	-1.64646106303001
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1184	79/9376	0.501197399931577	GSTP1/GSTK1/HSD11B1/ADH5/MGST1	-1.69253382352925
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1184	70/9376	0.452509652509653	GSTP1/GSTK1/HSD11B1/MGST1	-1.74787544106518
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/1184	82/9376	0.482860909690178	PDIA3/KLRD1/CREB1/CALR/CTSS	-1.78804925003782
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/1184	83/9376	0.47704330836861	SCP2/PRDX5/GSTK1/PEX14/IDH2	-1.81925392129225
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1184	31/9376	0.255448997384481	GUSB	-1.57852754418557
NA	NA	hsa04981	Folate transport and metabolism	1/1184	31/9376	0.255448997384481	ST20-MTHFS	-1.57852754418557
Human Diseases	Immune disease	hsa05310	Asthma	1/1184	32/9376	0.247466216216216	FCER1G	-1.62106747981026
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1184	73/9376	0.433913365420215	GSTP1/GSTK1/ADH5/MGST1	-1.84586246381241
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1184	48/9376	0.329954954954955	PRKCB/PLCB1	-1.76928121911657
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/1184	63/9376	0.377091377091377	AXIN1/BAX/GSK3B	-1.88588989584517
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/1184	154/9376	0.565637065637066	ADSS2/EPRS1/PTS/TPK1/GUSB/PMM2/NME3/PPCS/COQ5/GCLM/GPHN	-2.0661748810222
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/1184	144/9376	0.549924924924925	MAP2K4/MAPK8/GSK3B/FOXO1/RIPK1/TRAF3/ADH5/IRAK4/FASLG/CASP3	-2.06911594901473
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1184	89/9376	0.444883085332524	CD47/ITGB7/ITGA4/COL6A2/COL6A1	-2.00036044759169
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/1184	36/9376	0.21996996996997	GYG1	-1.78260718461026
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1184	66/9376	0.35995085995086	HSD11B1/HSD17B12/HSD17B11	-1.98370443035727
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1184	37/9376	0.214024835646457	ADH5	-1.8210673799887
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/1184	38/9376	0.208392603129445	PRKCB	-1.8588366415391
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/1184	39/9376	0.203049203049203	ST20-MTHFS	-1.8959490003243
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/1184	71/9376	0.334602207841644	MAP2K2/IDH2/MAP2K1	-2.13953235620125
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1184	41/9376	0.193144363876071	GRHPR	-1.96832641978801
NA	NA	hsa04081	Hormone signaling	16/1184	219/9376	0.57855115389362	GNG2/GNAI2/PLCB1/ESR2/GNG5/GNB1/GNAQ/RHOA/VIPR2/RAMP1/OPRM1/PRL/GNAI3/GNA13/GNB2/GNGT2	-2.39914687977497
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/1184	144/9376	0.43993993993994	JAK1/AXIN1/JARID2/KAT6A/GSK3B/MAP2K2/JAK3/MAP2K1	-2.57474645198497
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1184	68/9376	0.232909379968203	ALDH1A2/ADH5	-2.41345640736761
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/1184	70/9376	0.226254826254826	PRKCQ/MAPK8	-2.47019914237984
NA	NA	hsa04082	Neuroactive ligand signaling	12/1184	199/9376	0.477522748879533	GNG2/PRKCB/GNAI2/PLCB1/GNG5/GNB1/GNAQ/SLC18A2/OPRM1/GNAI3/GNB2/GNGT2	-2.83210972798405
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/1184	90/9376	0.263963963963964	SLC4A4/SLC10A1/SLC51A	-2.66730396392387
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/1184	76/9376	0.208392603129445	DBI/SCP2	-2.6341571640317
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/1184	298/9376	0.504897514964629	CX3CR1/IL12RB2/TGFB1/IFNGR1/IL2RB/IL21R/CXCR2/RELL1/CXCL14/TGFBR1/IL18RAP/PRL/IL12RB1/IL24/CSF2/CXCR1/CCL28/IL3RA/FASLG	-3.30198173464236
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/1184	323/9376	0.490335536775165	RASSF1/PRKCB/EFNA5/ATM/ABL1/CDK6/PRKCE/RHOA/SOS1/MAP2K2/SOS2/RPS6KA5/HDAC1/ZEB2/CREBBP/PDCD4/RPTOR/MAP2K1/CASP3/HDAC4	-3.54369121269058
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/1184	103/9376	0.153765415901338	COL6A2/COL6A1	-3.28296135292514
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1184	86/9376	0.0920804525455688	PLCB1	-3.2155498943365
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/1184	183/9376	0.259636685866194	NOP10/PWP2/XRN1/CSNK2A1/POP4/SNU13	-3.84510605736989
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1184	370/9376	0.29963476990504	GZMA/P2RY8/PTGDR/S1PR5/NMUR1/NR3C1/VIPR2/OPRM1/PRL/PGRMC2/S1PR1/UTS2/F2RL2/NPW	-5.22547754142079
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1184	449/9376	0.10582074279179	CALM1/NCALD/CAMK2D/GNB1/ARRB1/ARRB2	-7.38178703743233