ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 73/2194 175/18639 0.417142857142857 3.54381299648392 6.57809494116747e-24 8.09763487257716e-21 GO:0015078 proton transmembrane transporter activity 57/2194 185/18639 0.308108108108108 2.61751459755106 3.20860496722405e-12 1.41512975298731e-09 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 31/2194 68/18639 0.455882352941176 3.87292214059735 3.44873213563113e-12 1.41512975298731e-09 GO:0009055 electron transfer activity 38/2194 116/18639 0.327586206896552 2.78298965831578 1.8785187370618e-09 5.78114141330769e-07 GO:0022853 active monoatomic ion transmembrane transporter activity 38/2194 118/18639 0.322033898305085 2.73582034207314 3.2327878900705e-09 7.95912378535357e-07 GO:0004812 aminoacyl-tRNA ligase activity 19/2194 41/18639 0.463414634146341 3.93691219956867 3.83557582104838e-08 5.90199229463819e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity 19/2194 41/18639 0.463414634146341 3.93691219956867 3.83557582104838e-08 5.90199229463819e-06 GO:0016875 ligase activity, forming carbon-oxygen bonds 19/2194 41/18639 0.463414634146341 3.93691219956867 3.83557582104838e-08 5.90199229463819e-06 GO:0030695 GTPase regulator activity 97/2194 489/18639 0.198364008179959 1.6851899491642 1.36329136468005e-07 1.74130162682229e-05 GO:0060589 nucleoside-triphosphatase regulator activity 97/2194 490/18639 0.197959183673469 1.68175078600264 1.50748382241356e-07 1.74130162682229e-05 GO:0003954 NADH dehydrogenase activity 19/2194 44/18639 0.431818181818182 3.6684863677799 1.55599657961374e-07 1.74130162682229e-05 GO:0031625 ubiquitin protein ligase binding 67/2194 302/18639 0.221854304635762 1.88475040296534 1.85862097847159e-07 1.90663535374877e-05 GO:0044389 ubiquitin-like protein ligase binding 70/2194 322/18639 0.217391304347826 1.84683524236059 2.27435220006583e-07 2.15363658329311e-05 GO:0016874 ligase activity 43/2194 167/18639 0.25748502994012 2.18744916729895 4.55385918241884e-07 4.00414332396971e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 10/2194 15/18639 0.666666666666667 5.66362807657247 8.58229789162848e-07 7.0432058030631e-05 GO:0045296 cadherin binding 70/2194 334/18639 0.209580838323353 1.78048188035961 9.57479497739018e-07 7.36660788572957e-05 GO:0051020 GTPase binding 66/2194 315/18639 0.20952380952381 1.7799973954942 1.95580541644367e-06 0.000141623321626009 GO:0031492 nucleosomal DNA binding 17/2194 42/18639 0.404761904761905 3.43863133220471 2.09769817524266e-06 0.000143459247429095 GO:0003743 translation initiation factor activity 19/2194 51/18639 0.372549019607843 3.16496863102579 2.36751169889274e-06 0.000153389836912471 GO:0019003 GDP binding 24/2194 75/18639 0.32 2.71854147675479 2.79700582416684e-06 0.000172155708477469 GO:0019902 phosphatase binding 45/2194 190/18639 0.236842105263158 2.01207839562443 2.99342563060607e-06 0.000175471759584575 GO:0005085 guanyl-nucleotide exchange factor activity 51/2194 230/18639 0.221739130434783 1.8837719472078 5.27960211226195e-06 0.000290930174264238 GO:0055106 ubiquitin-protein transferase regulator activity 15/2194 36/18639 0.416666666666667 3.53976754785779 5.43573843060722e-06 0.000290930174264238 GO:0015399 primary active transmembrane transporter activity 40/2194 166/18639 0.240963855421687 2.04709448550812 6.66004386693854e-06 0.000341604750008389 GO:0061650 ubiquitin-like protein conjugating enzyme activity 16/2194 41/18639 0.390243902439024 3.3152944838473 7.34287734104048e-06 0.000361563280272833 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 10/2194 18/18639 0.555555555555556 4.71969006381039 8.93709428031979e-06 0.000423137040733603 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 19/2194 58/18639 0.327586206896552 2.78298965831578 2.05220000618069e-05 0.000935651188003121 GO:0034450 ubiquitin-ubiquitin ligase activity 9/2194 16/18639 0.5625 4.77868618960802 2.24697532431392e-05 0.000971881255612907 GO:0019787 ubiquitin-like protein transferase activity 87/2194 479/18639 0.181628392484342 1.54301349476557 2.28956591492886e-05 0.000971881255612907 GO:0003925 G protein activity 18/2194 54/18639 0.333333333333333 2.83181403828624 2.5804149375227e-05 0.00102674880018503 GO:0019208 phosphatase regulator activity 30/2194 117/18639 0.256410256410256 2.17831849098941 2.58563873320356e-05 0.00102674880018503 GO:0004715 non-membrane spanning protein tyrosine kinase activity 16/2194 45/18639 0.355555555555556 3.02060164083865 2.9065305154223e-05 0.00111810595765152 GO:0003712 transcription coregulator activity 88/2194 495/18639 0.177777777777778 1.51030082041933 4.66513152356894e-05 0.00174023542591314 GO:0051219 phosphoprotein binding 25/2194 93/18639 0.268817204301075 2.28372099861793 5.11773228380839e-05 0.00185292012981416 GO:1990948 ubiquitin ligase inhibitor activity 7/2194 11/18639 0.636363636363636 5.40619043672827 6.64987703549037e-05 0.00233885675162533 GO:0019210 kinase inhibitor activity 24/2194 90/18639 0.266666666666667 2.26545123062899 8.24287252088357e-05 0.00272768450570526 GO:0016755 aminoacyltransferase activity 87/2194 496/18639 0.175403225806452 1.4901279515982 8.4033373029373e-05 0.00272768450570526 GO:0031491 nucleosome binding 21/2194 74/18639 0.283783783783784 2.41086870827071 8.53950858926607e-05 0.00272768450570526 GO:0019888 protein phosphatase regulator activity 27/2194 107/18639 0.252336448598131 2.14370969253444 8.64172995308733e-05 0.00272768450570526 GO:0061631 ubiquitin conjugating enzyme activity 13/2194 35/18639 0.371428571428571 3.15544992837609 9.64164385159923e-05 0.00290493692611145 GO:0045309 protein phosphorylated amino acid binding 18/2194 59/18639 0.305084745762712 2.5918297977535 9.67525702441669e-05 0.00290493692611145 GO:0004129 cytochrome-c oxidase activity 8/2194 15/18639 0.533333333333333 4.53090246125798 0.000108858913129256 0.00304557550141169 GO:0031386 protein tag activity 8/2194 15/18639 0.533333333333333 4.53090246125798 0.000108858913129256 0.00304557550141169 GO:0141047 molecular tag activity 8/2194 15/18639 0.533333333333333 4.53090246125798 0.000108858913129256 0.00304557550141169 GO:0017124 SH3 domain binding 28/2194 115/18639 0.243478260869565 2.06845547144386 0.000126026027583188 0.00339262103657951 GO:0004721 phosphoprotein phosphatase activity 38/2194 175/18639 0.217142857142857 1.84472457351218 0.000126775440847 0.00339262103657951 GO:0004842 ubiquitin-protein transferase activity 79/2194 449/18639 0.175946547884187 1.49474371285933 0.000157571692123729 0.00410079760834342 GO:0016791 phosphatase activity 53/2194 273/18639 0.194139194139194 1.64929828603484 0.000159901125264406 0.00410079760834342 GO:0003779 actin binding 78/2194 443/18639 0.17607223476298 1.49581147846271 0.000168874293291293 0.00424253581717514 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2194 16/18639 0.5 4.24772105742935 0.000195248073015372 0.00480700755763846 GO:0140789 histone phosphatase activity 31/2194 136/18639 0.227941176470588 1.93646107029868 0.000206407380635542 0.00498210756004613 GO:0003924 GTPase activity 61/2194 331/18639 0.18429003021148 1.56562528400719 0.000241956683045971 0.0057278591697998 GO:0008200 ion channel inhibitor activity 14/2194 43/18639 0.325581395348837 2.76595789786097 0.000266100261535089 0.00613432026576073 GO:0019903 protein phosphatase binding 32/2194 144/18639 0.222222222222222 1.88787602552416 0.000269092846751486 0.00613432026576073 GO:0072542 protein phosphatase activator activity 9/2194 21/18639 0.428571428571429 3.64090376351087 0.000332680149615341 0.00744598662139064 GO:0140297 DNA-binding transcription factor binding 83/2194 488/18639 0.170081967213115 1.44492150724031 0.000339552584827087 0.00746409342718114 GO:0016248 channel inhibitor activity 14/2194 44/18639 0.318181818181818 2.70309521836413 0.000348410696774496 0.00752444855665622 GO:0050815 phosphoserine residue binding 6/2194 10/18639 0.6 5.09726526891522 0.000363806154275577 0.00764956191515656 GO:0019843 rRNA binding 18/2194 65/18639 0.276923076923077 2.35258397026856 0.000372938896110391 0.00764956191515656 GO:0017022 myosin binding 20/2194 76/18639 0.263157894736842 2.23564266180492 0.000378810458826133 0.00764956191515656 GO:0140996 histone H3 kinase activity 64/2194 357/18639 0.179271708683473 1.52299242395226 0.000379060338606458 0.00764956191515656 GO:0016651 oxidoreductase activity, acting on NAD(P)H 22/2194 88/18639 0.25 2.12386052871468 0.000433067936505835 0.00859849402965618 GO:0141110 transporter inhibitor activity 14/2194 45/18639 0.311111111111111 2.64302643573382 0.000451542018853818 0.00882298770173096 GO:0035173 histone kinase activity 64/2194 360/18639 0.177777777777778 1.51030082041933 0.000477667312033618 0.00918763220489663 GO:0008135 translation factor activity, RNA binding 21/2194 83/18639 0.253012048192771 2.14944920978353 0.000487379967369555 0.00923022676664497 GO:0004860 protein kinase inhibitor activity 21/2194 84/18639 0.25 2.12386052871468 0.000578865620754736 0.0106355758081952 GO:0180051 translation factor activity 21/2194 84/18639 0.25 2.12386052871468 0.000578865620754736 0.0106355758081952 GO:0042578 phosphoric ester hydrolase activity 64/2194 363/18639 0.176308539944904 1.49781899545718 0.000598753076009277 0.0108391917142268 GO:0015252 proton channel activity 10/2194 27/18639 0.37037037037037 3.14646004254026 0.000633365968880856 0.0112996160535121 GO:0031267 small GTPase binding 52/2194 283/18639 0.183745583038869 1.56099996456768 0.000717223353233992 0.0124933499076177 GO:0070990 snRNP binding 6/2194 11/18639 0.545454545454545 4.63387751719566 0.000720575014980385 0.0124933499076177 GO:0000287 magnesium ion binding 44/2194 230/18639 0.191304347826087 1.62521501327732 0.000759358930192049 0.0129829283759224 GO:0141003 histone H2AX kinase activity 62/2194 354/18639 0.175141242937853 1.48790229130294 0.000858693967529821 0.0144801681373864 GO:0035591 signaling adaptor activity 28/2194 129/18639 0.217054263565891 1.84397193190732 0.00093106167420501 0.0154883367695455 GO:0019207 kinase regulator activity 52/2194 287/18639 0.181184668989547 1.53924386750053 0.000996996646799855 0.0163640382961416 GO:0001222 transcription corepressor binding 14/2194 49/18639 0.285714285714286 2.42726917567392 0.00116205830776273 0.0188222865375779 GO:0051015 actin filament binding 40/2194 209/18639 0.191387559808612 1.62592193585813 0.00127319680920903 0.0203546139238483 GO:0003714 transcription corepressor activity 39/2194 204/18639 0.191176470588235 1.62412863960534 0.00148380015608405 0.0232511754039062 GO:0019211 phosphatase activator activity 9/2194 25/18639 0.36 3.05835916134913 0.00149215504216782 0.0232511754039062 GO:0061659 ubiquitin-like protein ligase activity 63/2194 372/18639 0.169354838709677 1.4387442291293 0.00184533435793113 0.0283950824326652 GO:0004857 enzyme inhibitor activity 69/2194 416/18639 0.165865384615385 1.40909977385878 0.00200141009037936 0.0304164916204567 GO:0031489 myosin V binding 7/2194 17/18639 0.411764705882353 3.49812322376535 0.00206263381421519 0.0309646612841329 GO:0005096 GTPase activator activity 48/2194 271/18639 0.177121771217712 1.50472775466132 0.00245727564016719 0.0364446543740459 GO:0031369 translation initiation factor binding 10/2194 32/18639 0.3125 2.65482566089335 0.00279186575030532 0.040914127840784 GO:0032182 ubiquitin-like protein binding 25/2194 120/18639 0.208333333333333 1.7698837739289 0.00306201110691827 0.0443451255601928 GO:0005522 profilin binding 5/2194 10/18639 0.5 4.24772105742935 0.00340000857824537 0.0470175269404864 GO:0008140 cAMP response element binding protein binding 5/2194 10/18639 0.5 4.24772105742935 0.00340000857824537 0.0470175269404864 GO:0061630 ubiquitin protein ligase activity 59/2194 353/18639 0.1671388101983 1.41991808718602 0.00340869926266174 0.0470175269404864 GO:0098847 sequence-specific single stranded DNA binding 6/2194 14/18639 0.428571428571429 3.64090376351087 0.00342361333720039 0.0470175269404864 GO:0003697 single-stranded DNA binding 25/2194 121/18639 0.206611570247934 1.75525663530139 0.00343751212399982 0.0470175269404864 GO:0019887 protein kinase regulator activity 45/2194 255/18639 0.176470588235294 1.49919566732801 0.00352902449954945 0.0475129835507818 GO:0004674 protein serine/threonine kinase activity 70/2194 433/18639 0.161662817551963 1.37339710863767 0.0035833046034896 0.0475129835507818 GO:0071889 14-3-3 protein binding 10/2194 33/18639 0.303030303030303 2.57437639844203 0.00358952678328409 0.0475129835507818 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 26/2194 128/18639 0.203125 1.72563667958067 0.00367992363399153 0.0481913403557827 GO:0003713 transcription coactivator activity 45/2194 256/18639 0.17578125 1.49333943425251 0.00380534493997207 0.0493092591695328 GO:0043014 alpha-tubulin binding 12/2194 44/18639 0.272727272727273 2.31693875859783 0.00391480065073383 0.0501991625109723 GO:0005525 GTP binding 62/2194 378/18639 0.164021164021164 1.39343230455354 0.00423445886102638 0.0537383387414791 GO:0048306 calcium-dependent protein binding 18/2194 80/18639 0.225 1.91147447584321 0.0047809254251393 0.0600542775341477 GO:0032050 clathrin heavy chain binding 5/2194 11/18639 0.454545454545455 3.86156459766305 0.00563286988096618 0.0700410386209027 GO:0140101 catalytic activity, acting on a tRNA 27/2194 139/18639 0.194244604316547 1.65019379209486 0.0058892328143362 0.0724964559444786 GO:0016408 C-acyltransferase activity 7/2194 20/18639 0.35 2.97340474020055 0.00598375720054939 0.0729307437017456 GO:0019001 guanyl nucleotide binding 64/2194 400/18639 0.16 1.35927073837739 0.00653000207445309 0.0780430345014734 GO:0032561 guanyl ribonucleotide binding 64/2194 400/18639 0.16 1.35927073837739 0.00653000207445309 0.0780430345014734 GO:0051540 metal cluster binding 17/2194 77/18639 0.220779220779221 1.87561709029348 0.00732100813318198 0.0866553943456445 GO:0070063 RNA polymerase binding 14/2194 59/18639 0.23728813559322 2.01586762047495 0.00743701732780637 0.0871901745764728 GO:0050681 nuclear androgen receptor binding 8/2194 26/18639 0.307692307692308 2.61398218918729 0.00806160408810887 0.093621081438321 GO:0140857 histone H3T45 kinase activity 42/2194 246/18639 0.170731707317073 1.45044133668319 0.00841384607334735 0.0967985468812205 GO:0106310 protein serine kinase activity 58/2194 361/18639 0.160664819944598 1.36491867773353 0.00851285794555273 0.0970308160275501 GO:0034452 dynactin binding 5/2194 12/18639 0.416666666666667 3.53976754785779 0.0087293304818259 0.0976891438466153 GO:0043047 single-stranded telomeric DNA binding 5/2194 12/18639 0.416666666666667 3.53976754785779 0.0087293304818259 0.0976891438466153 GO:0035402 histone H3T11 kinase activity 42/2194 247/18639 0.17004048582996 1.44456910455087 0.00901508904312684 0.0990854876079388 GO:0035403 histone H3T6 kinase activity 42/2194 247/18639 0.17004048582996 1.44456910455087 0.00901508904312684 0.0990854876079388 GO:0016922 nuclear receptor binding 26/2194 137/18639 0.18978102189781 1.61227368603158 0.00921445743617021 0.100380505344474 GO:0048156 tau protein binding 11/2194 43/18639 0.255813953488372 2.17325263403362 0.00942474182798561 0.101770677107459 GO:0051059 NF-kappaB binding 9/2194 32/18639 0.28125 2.38934309480401 0.00958457917851397 0.102596669293484 GO:0032183 SUMO binding 6/2194 17/18639 0.352941176470588 2.99839133465601 0.0103407906898417 0.107031036931346 GO:0042162 telomeric DNA binding 10/2194 38/18639 0.263157894736842 2.23564266180492 0.0106196599681312 0.107031036931346 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 41/2194 243/18639 0.168724279835391 1.43338735271279 0.0111147463812331 0.107031036931346 GO:0001046 core promoter sequence-specific DNA binding 11/2194 44/18639 0.25 2.12386052871468 0.0112613888870695 0.107031036931346 GO:0099106 ion channel regulator activity 29/2194 160/18639 0.18125 1.53979888331814 0.0117408993484189 0.107031036931346 GO:0043130 ubiquitin binding 20/2194 100/18639 0.2 1.69908842297174 0.0118715221067115 0.107031036931346 GO:0033192 calmodulin-dependent protein phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0140791 histone H2AXS140 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:1990439 MAP kinase serine/threonine phosphatase activity 17/2194 81/18639 0.209876543209877 1.78299402410615 0.0122000606712393 0.107031036931346 GO:0004676 3-phosphoinositide-dependent protein kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0004711 ribosomal protein S6 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0035175 histone H3S10 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0035979 histone H2AXS139 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0044022 histone H3S28 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0044023 histone H4S1 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0044024 histone H2AS1 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0044025 histone H2BS14 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0072354 histone H3T3 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0072371 histone H2AS121 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0072518 Rho-dependent protein serine/threonine kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0140823 histone H2BS36 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0140855 histone H3S57 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0140995 histone H2A kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0140997 histone H4 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0140998 histone H2B kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:1990244 histone H2AT120 kinase activity 41/2194 245/18639 0.16734693877551 1.42168623146615 0.0126941765978689 0.107031036931346 GO:0019855 calcium channel inhibitor activity 5/2194 13/18639 0.384615384615385 3.26747773648412 0.0128281885392371 0.10717517393071 GO:0016247 channel regulator activity 30/2194 168/18639 0.178571428571429 1.5170432347962 0.0128853986529205 0.10717517393071 GO:0004677 DNA-dependent protein kinase activity 41/2194 246/18639 0.166666666666667 1.41590701914312 0.0135502427027732 0.111948649443717 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 17/2194 82/18639 0.207317073170732 1.76125019454388 0.0137500763252468 0.112094993088601 GO:0033549 MAP kinase phosphatase activity 17/2194 82/18639 0.207317073170732 1.76125019454388 0.0137500763252468 0.112094993088601 GO:0070064 proline-rich region binding 6/2194 18/18639 0.333333333333333 2.83181403828624 0.0139935463040089 0.113142423645371 GO:0005543 phospholipid binding 75/2194 497/18639 0.150905432595573 1.28200836743341 0.0140623808430071 0.113142423645371 GO:0051536 iron-sulfur cluster binding 16/2194 76/18639 0.210526315789474 1.78851412944394 0.0143358088717628 0.114593381306104 GO:0141108 transporter regulator activity 30/2194 170/18639 0.176470588235294 1.49919566732801 0.015091661625019 0.118129606732302 GO:0043021 ribonucleoprotein complex binding 31/2194 177/18639 0.175141242937853 1.48790229130294 0.0151508635344936 0.118129606732302 GO:0061791 GTPase motor activity 10/2194 40/18639 0.25 2.12386052871468 0.0153252938703389 0.118129606732302 GO:1990606 membrane scission GTPase motor activity 10/2194 40/18639 0.25 2.12386052871468 0.0153252938703389 0.118129606732302 GO:0035091 phosphatidylinositol binding 46/2194 284/18639 0.161971830985915 1.37602231437852 0.0153369610539717 0.118129606732302 GO:0004679 AMP-activated protein kinase activity 41/2194 248/18639 0.165322580645161 1.40448841415003 0.015403837652196 0.118129606732302 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 17/2194 83/18639 0.204819277108434 1.7400303126819 0.0154499323183595 0.118129606732302 GO:0003785 actin monomer binding 8/2194 29/18639 0.275862068965517 2.34357023858171 0.0160940175630043 0.122294664321347 GO:0004722 protein serine/threonine phosphatase activity 20/2194 103/18639 0.194174757281553 1.64960041065218 0.0162472705139326 0.122701779157368 GO:0017018 myosin phosphatase activity 17/2194 84/18639 0.202380952380952 1.71931566610236 0.0173086714386899 0.129920576469679 GO:0032036 myosin heavy chain binding 5/2194 14/18639 0.357142857142857 3.0340864695924 0.0180529525403686 0.133874605886709 GO:0034236 protein kinase A catalytic subunit binding 5/2194 14/18639 0.357142857142857 3.0340864695924 0.0180529525403686 0.133874605886709 GO:0005246 calcium channel regulator activity 12/2194 53/18639 0.226415094339623 1.92349632789254 0.0183209203472333 0.135048221242181 GO:0070566 adenylyltransferase activity 8/2194 30/18639 0.266666666666667 2.26545123062899 0.0197398002753501 0.144641036541404 GO:0015631 tubulin binding 59/2194 385/18639 0.153246753246753 1.30189892149783 0.0202884419915224 0.14541067936994 GO:0043178 alcohol binding 18/2194 92/18639 0.195652173913043 1.66215171812453 0.0203053382043229 0.14541067936994 GO:0005200 structural constituent of cytoskeleton 21/2194 112/18639 0.1875 1.59289539653601 0.0203807909372667 0.14541067936994 GO:0016835 carbon-oxygen lyase activity 16/2194 79/18639 0.20253164556962 1.72059587136379 0.0203969014431985 0.14541067936994 GO:0001098 basal transcription machinery binding 13/2194 60/18639 0.216666666666667 1.84067912488605 0.0205535809994878 0.14541067936994 GO:0001099 basal RNA polymerase II transcription machinery binding 13/2194 60/18639 0.216666666666667 1.84067912488605 0.0205535809994878 0.14541067936994 GO:0000993 RNA polymerase II complex binding 9/2194 36/18639 0.25 2.12386052871468 0.0209325784551891 0.146409114081465 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2194 36/18639 0.25 2.12386052871468 0.0209325784551891 0.146409114081465 GO:0015485 cholesterol binding 12/2194 54/18639 0.222222222222222 1.88787602552416 0.0211074389441332 0.146798064069085 GO:0000149 SNARE binding 20/2194 106/18639 0.188679245283019 1.60291360657711 0.0217945120962081 0.150724968485574 GO:0070513 death domain binding 4/2194 10/18639 0.4 3.39817684594348 0.0223936036505678 0.151464429087082 GO:0098505 G-rich strand telomeric DNA binding 4/2194 10/18639 0.4 3.39817684594348 0.0223936036505678 0.151464429087082 GO:0099122 RNA polymerase II C-terminal domain binding 4/2194 10/18639 0.4 3.39817684594348 0.0223936036505678 0.151464429087082 GO:1905394 retromer complex binding 4/2194 10/18639 0.4 3.39817684594348 0.0223936036505678 0.151464429087082 GO:0000049 tRNA binding 16/2194 80/18639 0.2 1.69908842297174 0.0227983974790459 0.153359712003855 GO:0019905 syntaxin binding 13/2194 61/18639 0.213114754098361 1.81050405726497 0.023393139400865 0.156505188056874 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/2194 15/18639 0.333333333333333 2.83181403828624 0.0245079275509262 0.1622003162107 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/2194 15/18639 0.333333333333333 2.83181403828624 0.0245079275509262 0.1622003162107 GO:0031490 chromatin DNA binding 23/2194 128/18639 0.1796875 1.52652475501367 0.0251550930319591 0.165593152525891 GO:0032934 sterol binding 14/2194 68/18639 0.205882352941176 1.74906161188267 0.0253163694563744 0.165768355323388 GO:0004197 cysteine-type endopeptidase activity 17/2194 88/18639 0.193181818181818 1.6411649540068 0.0265134610952967 0.172126880427959 GO:0035401 histone H3Y41 kinase activity 21/2194 115/18639 0.182608695652174 1.55134160358289 0.0267069327065313 0.172126880427959 GO:0140801 histone H2AXY142 kinase activity 21/2194 115/18639 0.182608695652174 1.55134160358289 0.0267069327065313 0.172126880427959 GO:0022884 macromolecule transmembrane transporter activity 8/2194 32/18639 0.25 2.12386052871468 0.0287205478286814 0.184140595714098 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 17/2194 89/18639 0.191011235955056 1.6227248983438 0.0293017550829545 0.185930208799572 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 17/2194 89/18639 0.191011235955056 1.6227248983438 0.0293017550829545 0.185930208799572 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/2194 21/18639 0.285714285714286 2.42726917567392 0.0300925040630846 0.189968576931575 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 53/2194 349/18639 0.151862464183381 1.29013877388972 0.0309646792941353 0.194477143934085 GO:0140030 modification-dependent protein binding 29/2194 173/18639 0.167630057803468 1.42409145277978 0.0313310476241261 0.194921792192497 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 4/2194 11/18639 0.363636363636364 3.08925167813044 0.0319711658046258 0.194921792192497 GO:0008526 phosphatidylinositol transfer activity 4/2194 11/18639 0.363636363636364 3.08925167813044 0.0319711658046258 0.194921792192497 GO:0042608 T cell receptor binding 4/2194 11/18639 0.363636363636364 3.08925167813044 0.0319711658046258 0.194921792192497 GO:0140031 phosphorylation-dependent protein binding 4/2194 11/18639 0.363636363636364 3.08925167813044 0.0319711658046258 0.194921792192497 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/2194 16/18639 0.3125 2.65482566089335 0.0322755817726426 0.194921792192497 GO:0097027 ubiquitin-protein transferase activator activity 5/2194 16/18639 0.3125 2.65482566089335 0.0322755817726426 0.194921792192497 GO:0140793 histone H2AXY142 phosphatase activity 17/2194 90/18639 0.188888888888889 1.60469462169553 0.0323022303877087 0.194921792192497 GO:0005048 signal sequence binding 11/2194 51/18639 0.215686274509804 1.83235026006756 0.0326150788258221 0.195849570900425 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 7/2194 27/18639 0.259259259259259 2.20252202977818 0.0329617499185147 0.196970457037338 GO:0051539 4 iron, 4 sulfur cluster binding 10/2194 45/18639 0.222222222222222 1.88787602552416 0.0336262952788271 0.199970867092928 GO:0004725 protein tyrosine phosphatase activity 18/2194 98/18639 0.183673469387755 1.56038732721895 0.0362421156872336 0.214490598129733 GO:0043022 ribosome binding 20/2194 112/18639 0.178571428571429 1.5170432347962 0.0371200209910887 0.217601764859726 GO:0005080 protein kinase C binding 11/2194 52/18639 0.211538461538462 1.79711275506626 0.0371213408777762 0.217601764859726 GO:0140035 ubiquitin-like protein reader activity 6/2194 22/18639 0.272727272727273 2.31693875859783 0.0373778498491565 0.218066981821382 GO:0030276 clathrin binding 10/2194 46/18639 0.217391304347826 1.84683524236059 0.038594791082049 0.223052524985927 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2194 46/18639 0.217391304347826 1.84683524236059 0.038594791082049 0.223052524985927 GO:0046625 sphingolipid binding 7/2194 28/18639 0.25 2.12386052871468 0.0396289553314574 0.226240583612295 GO:0046875 ephrin receptor binding 7/2194 28/18639 0.25 2.12386052871468 0.0396289553314574 0.226240583612295 GO:0015036 disulfide oxidoreductase activity 9/2194 40/18639 0.225 1.91147447584321 0.0396977790903783 0.226240583612295 GO:0001786 phosphatidylserine binding 12/2194 59/18639 0.203389830508475 1.72788653183567 0.03989589283787 0.226321862135567 GO:0015035 protein-disulfide reductase activity 8/2194 34/18639 0.235294117647059 1.99892755643734 0.040177842829692 0.226581671990504 GO:0051087 protein-folding chaperone binding 23/2194 134/18639 0.171641791044776 1.45817290031157 0.0403098181689036 0.226581671990504 GO:0008429 phosphatidylethanolamine binding 5/2194 17/18639 0.294117647058824 2.49865944554668 0.0414150780571431 0.229648473370915 GO:0032977 membrane insertase activity 5/2194 17/18639 0.294117647058824 2.49865944554668 0.0414150780571431 0.229648473370915 GO:0051787 misfolded protein binding 5/2194 17/18639 0.294117647058824 2.49865944554668 0.0414150780571431 0.229648473370915 GO:1901981 phosphatidylinositol phosphate binding 30/2194 185/18639 0.162162162162162 1.37763926186898 0.0427567820404336 0.236025106241138 GO:0004300 enoyl-CoA hydratase activity 4/2194 12/18639 0.333333333333333 2.83181403828624 0.0435920834660258 0.238497132207457 GO:0097371 MDM2/MDM4 family protein binding 4/2194 12/18639 0.333333333333333 2.83181403828624 0.0435920834660258 0.238497132207457 GO:0001784 phosphotyrosine residue binding 10/2194 47/18639 0.212765957446809 1.80754087550185 0.0440462617622573 0.239915700129817 GO:0022804 active transmembrane transporter activity 66/2194 457/18639 0.144420131291028 1.22691286560323 0.0455822442732638 0.243787277614459 GO:0043274 phospholipase binding 6/2194 23/18639 0.260869565217391 2.21620229083271 0.0456978888085714 0.243787277614459 GO:0070577 lysine-acetylated histone binding 6/2194 23/18639 0.260869565217391 2.21620229083271 0.0456978888085714 0.243787277614459 GO:0017080 sodium channel regulator activity 9/2194 41/18639 0.219512195121951 1.86485314716411 0.0457472470584403 0.243787277614459 GO:0042169 SH2 domain binding 9/2194 41/18639 0.219512195121951 1.86485314716411 0.0457472470584403 0.243787277614459 GO:0002020 protease binding 23/2194 136/18639 0.169117647058824 1.43672918118934 0.0466141987956852 0.246275015954886 GO:0044325 transmembrane transporter binding 23/2194 136/18639 0.169117647058824 1.43672918118934 0.0466141987956852 0.246275015954886 GO:0140463 chromatin-protein adaptor activity 11/2194 54/18639 0.203703703703704 1.73055302339714 0.0474014474605477 0.249364024888608 GO:0005548 phospholipid transporter activity 13/2194 68/18639 0.191176470588235 1.62412863960534 0.0518692314776219 0.267552124804875 GO:0008525 phosphatidylcholine transporter activity 5/2194 18/18639 0.277777777777778 2.3598450319052 0.0519618210391177 0.267552124804875 GO:0070628 proteasome binding 5/2194 18/18639 0.277777777777778 2.3598450319052 0.0519618210391177 0.267552124804875 GO:1990381 ubiquitin-specific protease binding 5/2194 18/18639 0.277777777777778 2.3598450319052 0.0519618210391177 0.267552124804875 GO:0035198 miRNA binding 9/2194 42/18639 0.214285714285714 1.82045188175544 0.0523802291453899 0.267552124804875 GO:0043175 RNA polymerase core enzyme binding 9/2194 42/18639 0.214285714285714 1.82045188175544 0.0523802291453899 0.267552124804875 GO:0048487 beta-tubulin binding 9/2194 42/18639 0.214285714285714 1.82045188175544 0.0523802291453899 0.267552124804875 GO:0140313 molecular sequestering activity 11/2194 55/18639 0.2 1.69908842297174 0.0532028239427408 0.270630893692207 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/2194 36/18639 0.222222222222222 1.88787602552416 0.054325393293508 0.272957384262483 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/2194 36/18639 0.222222222222222 1.88787602552416 0.054325393293508 0.272957384262483 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/2194 36/18639 0.222222222222222 1.88787602552416 0.054325393293508 0.272957384262483 GO:0048027 mRNA 5'-UTR binding 6/2194 24/18639 0.25 2.12386052871468 0.0550795342288227 0.274505694881299 GO:0140033 acetylation-dependent protein binding 6/2194 24/18639 0.25 2.12386052871468 0.0550795342288227 0.274505694881299 GO:0004535 poly(A)-specific ribonuclease activity 4/2194 13/18639 0.307692307692308 2.61398218918729 0.0572649256557096 0.281972493928714 GO:0031994 insulin-like growth factor I binding 4/2194 13/18639 0.307692307692308 2.61398218918729 0.0572649256557096 0.281972493928714 GO:0140333 glycerophospholipid flippase activity 4/2194 13/18639 0.307692307692308 2.61398218918729 0.0572649256557096 0.281972493928714 GO:0019212 phosphatase inhibitor activity 11/2194 56/18639 0.196428571428571 1.66874755827582 0.059460489632037 0.291616983016086 GO:0004713 protein tyrosine kinase activity 23/2194 140/18639 0.164285714285714 1.3956797760125 0.0613118741769597 0.299503639332688 GO:0097110 scaffold protein binding 13/2194 70/18639 0.185714285714286 1.57772496418805 0.0631213680487371 0.306206966634353 GO:0003756 protein disulfide isomerase activity 5/2194 19/18639 0.263157894736842 2.23564266180492 0.0639278557473832 0.306206966634353 GO:0005520 insulin-like growth factor binding 5/2194 19/18639 0.263157894736842 2.23564266180492 0.0639278557473832 0.306206966634353 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/2194 19/18639 0.263157894736842 2.23564266180492 0.0639278557473832 0.306206966634353 GO:0140036 ubiquitin-modified protein reader activity 5/2194 19/18639 0.263157894736842 2.23564266180492 0.0639278557473832 0.306206966634353 GO:0042826 histone deacetylase binding 21/2194 127/18639 0.165354330708661 1.40475814497664 0.0673973476988148 0.321574166733492 GO:0016530 metallochaperone activity 4/2194 14/18639 0.285714285714286 2.42726917567392 0.0729497149018462 0.34275228642814 GO:0019763 immunoglobulin receptor activity 4/2194 14/18639 0.285714285714286 2.42726917567392 0.0729497149018462 0.34275228642814 GO:0019992 diacylglycerol binding 4/2194 14/18639 0.285714285714286 2.42726917567392 0.0729497149018462 0.34275228642814 GO:0046030 inositol trisphosphate phosphatase activity 4/2194 14/18639 0.285714285714286 2.42726917567392 0.0729497149018462 0.34275228642814 GO:0140142 nucleocytoplasmic carrier activity 7/2194 32/18639 0.21875 1.85837796262534 0.0746986718274961 0.349500546218451 GO:0120013 lipid transfer activity 12/2194 65/18639 0.184615384615385 1.56838931351238 0.0749538133238595 0.349500546218451 GO:0043548 phosphatidylinositol 3-kinase binding 6/2194 26/18639 0.230769230769231 1.96048664189047 0.0770725659869598 0.355342055168343 GO:0050750 low-density lipoprotein particle receptor binding 6/2194 26/18639 0.230769230769231 1.96048664189047 0.0770725659869598 0.355342055168343 GO:0120014 phospholipid transfer activity 6/2194 26/18639 0.230769230769231 1.96048664189047 0.0770725659869598 0.355342055168343 GO:0140098 catalytic activity, acting on RNA 55/2194 387/18639 0.142118863049096 1.20736257446312 0.0795327986676164 0.365316698357596 GO:0005496 steroid binding 18/2194 108/18639 0.166666666666667 1.41590701914312 0.0804685951297195 0.368176090681283 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2194 39/18639 0.205128205128205 1.74265479279153 0.0808740113824133 0.368176090681283 GO:0031593 polyubiquitin modification-dependent protein binding 11/2194 59/18639 0.186440677966102 1.58389598751603 0.0810525756089584 0.368176090681283 GO:0004864 protein phosphatase inhibitor activity 10/2194 53/18639 0.188679245283019 1.60291360657711 0.0876268036244718 0.395123059566757 GO:0051018 protein kinase A binding 10/2194 53/18639 0.188679245283019 1.60291360657711 0.0876268036244718 0.395123059566757 GO:0008320 protein transmembrane transporter activity 6/2194 27/18639 0.222222222222222 1.88787602552416 0.0896756562922299 0.399018321317583 GO:0008252 nucleotidase activity 4/2194 15/18639 0.266666666666667 2.26545123062899 0.0905649103021807 0.399018321317583 GO:0015556 C4-dicarboxylate transmembrane transporter activity 4/2194 15/18639 0.266666666666667 2.26545123062899 0.0905649103021807 0.399018321317583 GO:0042809 nuclear vitamin D receptor binding 4/2194 15/18639 0.266666666666667 2.26545123062899 0.0905649103021807 0.399018321317583 GO:0050700 CARD domain binding 4/2194 15/18639 0.266666666666667 2.26545123062899 0.0905649103021807 0.399018321317583 GO:0120283 protein serine/threonine kinase binding 4/2194 15/18639 0.266666666666667 2.26545123062899 0.0905649103021807 0.399018321317583 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2194 40/18639 0.2 1.69908842297174 0.0911680694554221 0.399018321317583 GO:0001846 opsonin binding 5/2194 21/18639 0.238095238095238 2.0227243130616 0.0920562171033255 0.399018321317583 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/2194 21/18639 0.238095238095238 2.0227243130616 0.0920562171033255 0.399018321317583 GO:0051010 microtubule plus-end binding 5/2194 21/18639 0.238095238095238 2.0227243130616 0.0920562171033255 0.399018321317583 GO:0140312 cargo adaptor activity 5/2194 21/18639 0.238095238095238 2.0227243130616 0.0920562171033255 0.399018321317583 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 10/2194 54/18639 0.185185185185185 1.57323002127013 0.0967689300253636 0.416512422591687 GO:0017069 snRNA binding 10/2194 54/18639 0.185185185185185 1.57323002127013 0.0967689300253636 0.416512422591687 GO:0016836 hydro-lyase activity 11/2194 61/18639 0.180327868852459 1.5319649715319 0.0978410968651032 0.419659896309902 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/2194 41/18639 0.195121951219512 1.65764724192365 0.102179177915296 0.420430735904608 GO:0042287 MHC protein binding 8/2194 41/18639 0.195121951219512 1.65764724192365 0.102179177915296 0.420430735904608 GO:0042393 histone binding 36/2194 247/18639 0.145748987854251 1.23820208961503 0.103106611296043 0.420430735904608 GO:0046966 nuclear thyroid hormone receptor binding 6/2194 28/18639 0.214285714285714 1.82045188175544 0.103324756554259 0.420430735904608 GO:0051537 2 iron, 2 sulfur cluster binding 6/2194 28/18639 0.214285714285714 1.82045188175544 0.103324756554259 0.420430735904608 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0005131 growth hormone receptor binding 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0008239 dipeptidyl-peptidase activity 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0031996 thioesterase binding 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0051864 histone H3K36 demethylase activity 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0070097 delta-catenin binding 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:1990757 ubiquitin ligase activator activity 3/2194 10/18639 0.3 2.54863263445761 0.103826924220147 0.420430735904608 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 9/2194 48/18639 0.1875 1.59289539653601 0.104990378245282 0.421950307494266 GO:0019783 ubiquitin-like protein peptidase activity 20/2194 127/18639 0.15748031496063 1.33786489997775 0.107196598088782 0.421950307494266 GO:0008234 cysteine-type peptidase activity 28/2194 187/18639 0.149732620320856 1.27204480864195 0.10776625520313 0.421950307494266 GO:0031683 G-protein beta/gamma-subunit complex binding 5/2194 22/18639 0.227272727272727 1.93078229883152 0.10813808982514 0.421950307494266 GO:0046972 histone H4K16 acetyltransferase activity 5/2194 22/18639 0.227272727272727 1.93078229883152 0.10813808982514 0.421950307494266 GO:0070034 telomerase RNA binding 5/2194 22/18639 0.227272727272727 1.93078229883152 0.10813808982514 0.421950307494266 GO:0140517 protein-RNA adaptor activity 5/2194 22/18639 0.227272727272727 1.93078229883152 0.10813808982514 0.421950307494266 GO:0030527 structural constituent of chromatin 16/2194 98/18639 0.163265306122449 1.38701095752795 0.109444318570891 0.421950307494266 GO:0000062 fatty-acyl-CoA binding 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0004708 MAP kinase kinase activity 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0017070 U6 snRNA binding 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0030275 LRR domain binding 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0043023 ribosomal large subunit binding 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0140327 flippase activity 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0140328 floppase activity 4/2194 16/18639 0.25 2.12386052871468 0.109994686478693 0.421950307494266 GO:0010485 histone H4 acetyltransferase activity 7/2194 35/18639 0.2 1.69908842297174 0.110029284082583 0.421950307494266 GO:0140566 histone reader activity 7/2194 35/18639 0.2 1.69908842297174 0.110029284082583 0.421950307494266 GO:0004402 histone acetyltransferase activity 8/2194 42/18639 0.19047619047619 1.61817945044928 0.113896577625862 0.43407643051838 GO:0016859 cis-trans isomerase activity 8/2194 42/18639 0.19047619047619 1.61817945044928 0.113896577625862 0.43407643051838 GO:0005507 copper ion binding 11/2194 63/18639 0.174603174603175 1.48333116291184 0.11654550509265 0.44280097768226 GO:0051861 glycolipid binding 6/2194 29/18639 0.206896551724138 1.75767767893628 0.117987559667173 0.446900572154739 GO:0005484 SNAP receptor activity 7/2194 36/18639 0.194444444444444 1.65189152233364 0.123475050824773 0.466250882102135 GO:0044013 histone H2B acetyltransferase activity 5/2194 23/18639 0.217391304347826 1.84683524236059 0.12548259010752 0.468628861835347 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 5/2194 23/18639 0.217391304347826 1.84683524236059 0.12548259010752 0.468628861835347 GO:0016504 peptidase activator activity 10/2194 57/18639 0.175438596491228 1.49042844120328 0.127406280492701 0.468628861835347 GO:0000099 sulfur amino acid transmembrane transporter activity 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0001851 complement component C3b binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0002162 dystroglycan binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0005114 type II transforming growth factor beta receptor binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0019864 IgG binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0034056 estrogen response element binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0050786 RAGE receptor binding 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2194 11/18639 0.272727272727273 2.31693875859783 0.130772833625967 0.468628861835347 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/2194 17/18639 0.235294117647059 1.99892755643734 0.131096104454555 0.468628861835347 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2194 17/18639 0.235294117647059 1.99892755643734 0.131096104454555 0.468628861835347 GO:0019198 transmembrane receptor protein phosphatase activity 4/2194 17/18639 0.235294117647059 1.99892755643734 0.131096104454555 0.468628861835347 GO:1901567 fatty acid derivative binding 4/2194 17/18639 0.235294117647059 1.99892755643734 0.131096104454555 0.468628861835347 GO:0001968 fibronectin binding 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0016769 transferase activity, transferring nitrogenous groups 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0031210 phosphatidylcholine binding 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0031624 ubiquitin conjugating enzyme binding 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0043995 histone H4K5 acetyltransferase activity 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0043996 histone H4K8 acetyltransferase activity 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0043997 histone H4K12 acetyltransferase activity 6/2194 30/18639 0.2 1.69908842297174 0.13362203940228 0.468628861835347 GO:0031072 heat shock protein binding 20/2194 131/18639 0.152671755725191 1.29701406333721 0.13463188205958 0.47082911027086 GO:0061980 regulatory RNA binding 10/2194 58/18639 0.172413793103448 1.46473139911357 0.138661902309872 0.483549013437541 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0030552 cAMP binding 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0035035 histone acetyltransferase binding 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0043998 histone H2A acetyltransferase activity 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0050699 WW domain binding 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0070300 phosphatidic acid binding 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0070840 dynein complex binding 5/2194 24/18639 0.208333333333333 1.7698837739289 0.144009710075598 0.487021849184235 GO:0047499 calcium-independent phospholipase A2 activity 6/2194 31/18639 0.193548387096774 1.64427911900491 0.150177499130166 0.505105195161843 GO:0070325 lipoprotein particle receptor binding 6/2194 31/18639 0.193548387096774 1.64427911900491 0.150177499130166 0.505105195161843 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/2194 38/18639 0.184210526315789 1.56494986326345 0.152709019707303 0.508634307931532 GO:0140303 intramembrane lipid transporter activity 8/2194 45/18639 0.177777777777778 1.51030082041933 0.153107710676461 0.508634307931532 GO:0015172 acidic amino acid transmembrane transporter activity 4/2194 18/18639 0.222222222222222 1.88787602552416 0.153705899716109 0.508634307931532 GO:0031690 adrenergic receptor binding 4/2194 18/18639 0.222222222222222 1.88787602552416 0.153705899716109 0.508634307931532 GO:0035615 clathrin adaptor activity 4/2194 18/18639 0.222222222222222 1.88787602552416 0.153705899716109 0.508634307931532 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2194 18/18639 0.222222222222222 1.88787602552416 0.153705899716109 0.508634307931532 GO:0003684 damaged DNA binding 12/2194 74/18639 0.162162162162162 1.37763926186898 0.156107215076704 0.511050716907 GO:0003727 single-stranded RNA binding 14/2194 89/18639 0.157303370786517 1.33636168098901 0.158725164455792 0.511050716907 GO:0005049 nuclear export signal receptor activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0005078 MAP-kinase scaffold activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0005095 GTPase inhibitor activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0016273 arginine N-methyltransferase activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0016274 protein-arginine N-methyltransferase activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0017166 vinculin binding 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0035197 siRNA binding 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0035497 cAMP response element binding 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:1990817 poly(A) RNA polymerase activity 3/2194 12/18639 0.25 2.12386052871468 0.159833083679281 0.511050716907 GO:0001848 complement binding 5/2194 25/18639 0.2 1.69908842297174 0.163627854964923 0.519138890365516 GO:0017025 TBP-class protein binding 5/2194 25/18639 0.2 1.69908842297174 0.163627854964923 0.519138890365516 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2194 25/18639 0.2 1.69908842297174 0.163627854964923 0.519138890365516 GO:0034212 protein N-acetyltransferase activity 9/2194 53/18639 0.169811320754717 1.4426222459194 0.165391362565879 0.523385005960404 GO:0003725 double-stranded RNA binding 12/2194 75/18639 0.16 1.35927073837739 0.16718495703069 0.52764781188448 GO:0047498 calcium-dependent phospholipase A2 activity 6/2194 32/18639 0.1875 1.59289539653601 0.167595690046167 0.52764781188448 GO:1990841 promoter-specific chromatin binding 11/2194 68/18639 0.161764705882353 1.37426269505067 0.171350887410886 0.53809424082347 GO:0001540 amyloid-beta binding 13/2194 83/18639 0.156626506024096 1.33061141558028 0.173715711700019 0.542751373357167 GO:0030165 PDZ domain binding 13/2194 83/18639 0.156626506024096 1.33061141558028 0.173715711700019 0.542751373357167 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 4/2194 19/18639 0.210526315789474 1.78851412944394 0.177646711441102 0.549455029608032 GO:0031420 alkali metal ion binding 4/2194 19/18639 0.210526315789474 1.78851412944394 0.177646711441102 0.549455029608032 GO:0070003 threonine-type peptidase activity 4/2194 19/18639 0.210526315789474 1.78851412944394 0.177646711441102 0.549455029608032 GO:0120227 acyl-CoA binding 4/2194 19/18639 0.210526315789474 1.78851412944394 0.177646711441102 0.549455029608032 GO:0051287 NAD binding 9/2194 54/18639 0.166666666666667 1.41590701914312 0.179115849073982 0.552610551904942 GO:0043495 protein-membrane adaptor activity 8/2194 47/18639 0.170212765957447 1.44603270040148 0.182376960636852 0.553836635878898 GO:0061733 protein-lysine-acetyltransferase activity 8/2194 47/18639 0.170212765957447 1.44603270040148 0.182376960636852 0.553836635878898 GO:0002039 p53 binding 11/2194 69/18639 0.159420289855072 1.35434584439776 0.183598497112508 0.553836635878898 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/2194 26/18639 0.192307692307692 1.63373886824206 0.184236257102534 0.553836635878898 GO:0005112 Notch binding 5/2194 26/18639 0.192307692307692 1.63373886824206 0.184236257102534 0.553836635878898 GO:0005160 transforming growth factor beta receptor binding 5/2194 26/18639 0.192307692307692 1.63373886824206 0.184236257102534 0.553836635878898 GO:0008157 protein phosphatase 1 binding 5/2194 26/18639 0.192307692307692 1.63373886824206 0.184236257102534 0.553836635878898 GO:0004532 RNA exonuclease activity 7/2194 40/18639 0.175 1.48670237010027 0.184810321968089 0.553836635878898 GO:0030331 nuclear estrogen receptor binding 7/2194 40/18639 0.175 1.48670237010027 0.184810321968089 0.553836635878898 GO:0050997 quaternary ammonium group binding 7/2194 40/18639 0.175 1.48670237010027 0.184810321968089 0.553836635878898 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 18/2194 122/18639 0.147540983606557 1.25342588579883 0.185772528576191 0.553836635878898 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/2194 33/18639 0.181818181818182 1.54462583906522 0.185811966383416 0.553836635878898 GO:0019956 chemokine binding 6/2194 33/18639 0.181818181818182 1.54462583906522 0.185811966383416 0.553836635878898 GO:0140311 protein sequestering activity 6/2194 33/18639 0.181818181818182 1.54462583906522 0.185811966383416 0.553836635878898 GO:0002161 aminoacyl-tRNA editing activity 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0008253 5'-nucleotidase activity 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0030955 potassium ion binding 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0031432 titin binding 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0140666 annealing activity 3/2194 13/18639 0.230769230769231 1.96048664189047 0.190603531086353 0.559983166509069 GO:0001221 transcription coregulator binding 17/2194 115/18639 0.147826086956522 1.2558479648052 0.191993224842897 0.562722999480016 GO:0140693 molecular condensate scaffold activity 8/2194 48/18639 0.166666666666667 1.41590701914312 0.197854277115166 0.578524026434132 GO:0005319 lipid transporter activity 25/2194 178/18639 0.140449438202247 1.19318007231162 0.200823692636317 0.579034556202195 GO:0140318 protein transporter activity 7/2194 41/18639 0.170731707317073 1.45044133668319 0.201822616331899 0.579034556202195 GO:0046982 protein heterodimerization activity 49/2194 369/18639 0.132791327913279 1.12812103964248 0.202440364522392 0.579034556202195 GO:0000339 RNA cap binding 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0016004 phospholipase activator activity 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0016505 peptidase activator activity involved in apoptotic process 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0043024 ribosomal small subunit binding 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0052745 inositol phosphate phosphatase activity 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0061608 nuclear import signal receptor activity 4/2194 20/18639 0.2 1.69908842297174 0.202732651277942 0.579034556202195 GO:0008376 acetylgalactosaminyltransferase activity 6/2194 34/18639 0.176470588235294 1.49919566732801 0.204756449003968 0.582113599824212 GO:0052866 phosphatidylinositol phosphate phosphatase activity 6/2194 34/18639 0.176470588235294 1.49919566732801 0.204756449003968 0.582113599824212 GO:0001671 ATPase activator activity 5/2194 27/18639 0.185185185185185 1.57323002127013 0.205727302741239 0.5821846199413 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/2194 27/18639 0.185185185185185 1.57323002127013 0.205727302741239 0.5821846199413 GO:0016209 antioxidant activity 13/2194 86/18639 0.151162790697674 1.28419473829259 0.207979511290537 0.587208207336355 GO:0060590 ATPase regulator activity 8/2194 49/18639 0.163265306122449 1.38701095752795 0.213843469482944 0.602382862548064 GO:0008017 microtubule binding 37/2194 276/18639 0.134057971014493 1.13888173278903 0.222100974417319 0.617855073139086 GO:0005518 collagen binding 11/2194 72/18639 0.152777777777778 1.29791476754786 0.222616115115494 0.617855073139086 GO:0005161 platelet-derived growth factor receptor binding 3/2194 14/18639 0.214285714285714 1.82045188175544 0.222690935500309 0.617855073139086 GO:0042043 neurexin family protein binding 3/2194 14/18639 0.214285714285714 1.82045188175544 0.222690935500309 0.617855073139086 GO:0071933 Arp2/3 complex binding 3/2194 14/18639 0.214285714285714 1.82045188175544 0.222690935500309 0.617855073139086 GO:1990825 sequence-specific mRNA binding 3/2194 14/18639 0.214285714285714 1.82045188175544 0.222690935500309 0.617855073139086 GO:0004601 peroxidase activity 9/2194 57/18639 0.157894736842105 1.34138559708295 0.223128003424814 0.617855073139086 GO:0008276 protein methyltransferase activity 14/2194 95/18639 0.147368421052632 1.25195989061076 0.22411162923575 0.617855073139086 GO:0000175 3'-5'-RNA exonuclease activity 6/2194 35/18639 0.171428571428571 1.45636150540435 0.224355172780806 0.617855073139086 GO:0004623 phospholipase A2 activity 6/2194 35/18639 0.171428571428571 1.45636150540435 0.224355172780806 0.617855073139086 GO:0036408 histone H3K14 acetyltransferase activity 5/2194 28/18639 0.178571428571429 1.5170432347962 0.227988725825365 0.624436801248114 GO:0005123 death receptor binding 4/2194 21/18639 0.19047619047619 1.61817945044928 0.22877416520138 0.624436801248114 GO:0035613 RNA stem-loop binding 4/2194 21/18639 0.19047619047619 1.61817945044928 0.22877416520138 0.624436801248114 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2194 21/18639 0.19047619047619 1.61817945044928 0.22877416520138 0.624436801248114 GO:0016407 acetyltransferase activity 14/2194 96/18639 0.145833333333333 1.23891864175023 0.235992403520566 0.642164022951321 GO:0043539 protein serine/threonine kinase activator activity 11/2194 73/18639 0.150684931506849 1.28013511319789 0.236312187162428 0.642164022951321 GO:0004869 cysteine-type endopeptidase inhibitor activity 6/2194 36/18639 0.166666666666667 1.41590701914312 0.244531197172012 0.651300672430252 GO:0030544 Hsp70 protein binding 8/2194 51/18639 0.156862745098039 1.33261837095823 0.247193327519913 0.651300672430252 GO:0010484 histone H3 acetyltransferase activity 5/2194 29/18639 0.172413793103448 1.46473139911357 0.250905635441655 0.651300672430252 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/2194 29/18639 0.172413793103448 1.46473139911357 0.250905635441655 0.651300672430252 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/2194 59/18639 0.152542372881356 1.29591489887675 0.254522375212831 0.651300672430252 GO:0051082 unfolded protein binding 17/2194 121/18639 0.140495867768595 1.19357451200494 0.254670034205053 0.651300672430252 GO:0004407 histone deacetylase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0008970 phospholipase A1 activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0032931 histone H3K56 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0033558 protein lysine deacetylase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0034062 5'-3' RNA polymerase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0043992 histone H3K9 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0043993 histone H3K18 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0043994 histone H3K23 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0043999 histone H2AK5 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044012 histone H2AK9 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044014 histone H2BK5 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044015 histone H2BK12 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044016 histone H3K4 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044017 histone H3K27 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0044018 histone H3K36 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0050321 tau-protein kinase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0061133 endopeptidase activator activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0097747 RNA polymerase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0140908 histone H3K122 acetyltransferase activity 4/2194 22/18639 0.181818181818182 1.54462583906522 0.255582181951656 0.651300672430252 GO:0005523 tropomyosin binding 3/2194 15/18639 0.2 1.69908842297174 0.255722441799841 0.651300672430252 GO:0017081 chloride channel regulator activity 3/2194 15/18639 0.2 1.69908842297174 0.255722441799841 0.651300672430252 GO:0141050 histone H3K deacetylase activity 3/2194 15/18639 0.2 1.69908842297174 0.255722441799841 0.651300672430252 GO:0141051 histone H4K deacetylase activity 3/2194 15/18639 0.2 1.69908842297174 0.255722441799841 0.651300672430252 GO:0019205 nucleobase-containing compound kinase activity 7/2194 44/18639 0.159090909090909 1.35154760918207 0.256075975187849 0.651300672430252 GO:0003774 cytoskeletal motor activity 21/2194 153/18639 0.137254901960784 1.16604107458845 0.258998177118231 0.656142568210735 GO:0140104 molecular carrier activity 33/2194 249/18639 0.132530120481928 1.12590196702947 0.259045725548674 0.656142568210735 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 10/2194 67/18639 0.149253731343284 1.26797643505354 0.260179540089403 0.65766121940463 GO:0030551 cyclic nucleotide binding 6/2194 37/18639 0.162162162162162 1.37763926186898 0.265205663228891 0.668992154579435 GO:0051721 protein phosphatase 2A binding 5/2194 30/18639 0.166666666666667 1.41590701914312 0.27436235464953 0.690674966408123 GO:0140223 general transcription initiation factor activity 10/2194 68/18639 0.147058823529412 1.24932972277334 0.275494825033974 0.69211046860576 GO:0101005 deubiquitinase activity 16/2194 115/18639 0.139130434782609 1.18197455511078 0.27611875862935 0.692265156563606 GO:0005544 calcium-dependent phospholipid binding 8/2194 53/18639 0.150943396226415 1.28233088526169 0.282080889665424 0.699473900222766 GO:0016251 RNA polymerase II general transcription initiation factor activity 8/2194 53/18639 0.150943396226415 1.28233088526169 0.282080889665424 0.699473900222766 GO:0140296 general transcription initiation factor binding 8/2194 53/18639 0.150943396226415 1.28233088526169 0.282080889665424 0.699473900222766 GO:0004602 glutathione peroxidase activity 4/2194 23/18639 0.173913043478261 1.47746819388847 0.282971569708316 0.699473900222766 GO:0008171 O-methyltransferase activity 4/2194 23/18639 0.173913043478261 1.47746819388847 0.282971569708316 0.699473900222766 GO:0031681 G-protein beta-subunit binding 4/2194 23/18639 0.173913043478261 1.47746819388847 0.282971569708316 0.699473900222766 GO:0099186 structural constituent of postsynapse 4/2194 23/18639 0.173913043478261 1.47746819388847 0.282971569708316 0.699473900222766 GO:0000146 microfilament motor activity 6/2194 38/18639 0.157894736842105 1.34138559708295 0.286298783889189 0.706280166267718 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 18/2194 132/18639 0.136363636363636 1.15846937929891 0.289068380130575 0.706730591655044 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 3/2194 16/18639 0.1875 1.59289539653601 0.289351923797028 0.706730591655044 GO:0008142 oxysterol binding 3/2194 16/18639 0.1875 1.59289539653601 0.289351923797028 0.706730591655044 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/2194 16/18639 0.1875 1.59289539653601 0.289351923797028 0.706730591655044 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 3/2194 16/18639 0.1875 1.59289539653601 0.289351923797028 0.706730591655044 GO:0008080 N-acetyltransferase activity 10/2194 69/18639 0.144927536231884 1.23122349490706 0.291070473834223 0.709520303544413 GO:0070273 phosphatidylinositol-4-phosphate binding 5/2194 31/18639 0.161290322580645 1.37023259917076 0.298244057634023 0.725570029540479 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 8/2194 54/18639 0.148148148148148 1.2585840170161 0.299987853246544 0.727050171564693 GO:1990782 protein tyrosine kinase binding 16/2194 117/18639 0.136752136752137 1.16176986186102 0.300033701994203 0.727050171564693 GO:0033218 amide binding 32/2194 247/18639 0.129554655870445 1.10062407965781 0.30822237493914 0.745425822298785 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/2194 24/18639 0.166666666666667 1.41590701914312 0.31076394163486 0.747010285717532 GO:0005315 phosphate transmembrane transporter activity 4/2194 24/18639 0.166666666666667 1.41590701914312 0.31076394163486 0.747010285717532 GO:0060229 lipase activator activity 4/2194 24/18639 0.166666666666667 1.41590701914312 0.31076394163486 0.747010285717532 GO:0016410 N-acyltransferase activity 13/2194 94/18639 0.138297872340426 1.1749015690762 0.311304855055316 0.747010285717532 GO:0005504 fatty acid binding 7/2194 47/18639 0.148936170212766 1.2652786128513 0.313951843108189 0.751896340206578 GO:0120015 sterol transfer activity 5/2194 32/18639 0.15625 1.32741283044667 0.322438199779922 0.762968471727618 GO:0004659 prenyltransferase activity 3/2194 17/18639 0.176470588235294 1.49919566732801 0.3232638850847 0.762968471727618 GO:0005092 GDP-dissociation inhibitor activity 3/2194 17/18639 0.176470588235294 1.49919566732801 0.3232638850847 0.762968471727618 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2194 17/18639 0.176470588235294 1.49919566732801 0.3232638850847 0.762968471727618 GO:0016018 cyclosporin A binding 3/2194 17/18639 0.176470588235294 1.49919566732801 0.3232638850847 0.762968471727618 GO:0036041 long-chain fatty acid binding 3/2194 17/18639 0.176470588235294 1.49919566732801 0.3232638850847 0.762968471727618 GO:0000182 rDNA binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0001094 TFIID-class transcription factor complex binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0005528 FK506 binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0015279 store-operated calcium channel activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0031434 mitogen-activated protein kinase kinase binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0031720 haptoglobin binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0043208 glycosphingolipid binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0045322 unmethylated CpG binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0051880 G-quadruplex DNA binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0097177 mitochondrial ribosome binding 2/2194 10/18639 0.2 1.69908842297174 0.332830275643973 0.762968471727618 GO:0032266 phosphatidylinositol-3-phosphate binding 7/2194 48/18639 0.145833333333333 1.23891864175023 0.333773378765535 0.763708232825974 GO:0003707 nuclear steroid receptor activity 4/2194 25/18639 0.16 1.35927073837739 0.338789862905324 0.769465537336632 GO:0008139 nuclear localization sequence binding 4/2194 25/18639 0.16 1.35927073837739 0.338789862905324 0.769465537336632 GO:0008483 transaminase activity 4/2194 25/18639 0.16 1.35927073837739 0.338789862905324 0.769465537336632 GO:0017056 structural constituent of nuclear pore 4/2194 25/18639 0.16 1.35927073837739 0.338789862905324 0.769465537336632 GO:0005178 integrin binding 21/2194 161/18639 0.130434782608696 1.10810114541635 0.342193426249108 0.775764470925694 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/2194 41/18639 0.146341463414634 1.24323543144274 0.351296882132162 0.794938349089507 GO:0000400 four-way junction DNA binding 3/2194 18/18639 0.166666666666667 1.41590701914312 0.35717548215842 0.803808077764195 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2194 18/18639 0.166666666666667 1.41590701914312 0.35717548215842 0.803808077764195 GO:1901611 phosphatidylglycerol binding 3/2194 18/18639 0.166666666666667 1.41590701914312 0.35717548215842 0.803808077764195 GO:0008198 ferrous iron binding 4/2194 26/18639 0.153846153846154 1.30699109459365 0.366890518505832 0.821167687783053 GO:0019865 immunoglobulin binding 4/2194 26/18639 0.153846153846154 1.30699109459365 0.366890518505832 0.821167687783053 GO:0034237 protein kinase A regulatory subunit binding 4/2194 26/18639 0.153846153846154 1.30699109459365 0.366890518505832 0.821167687783053 GO:0030332 cyclin binding 5/2194 34/18639 0.147058823529412 1.24932972277334 0.371332171191302 0.824446817594151 GO:0032813 tumor necrosis factor receptor superfamily binding 7/2194 50/18639 0.14 1.18936189608022 0.373859462468822 0.824446817594151 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0003953 NAD+ nucleosidase activity 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0008432 JUN kinase binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0019107 myristoyltransferase activity 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0019206 nucleoside kinase activity 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0034511 U3 snoRNA binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0034713 type I transforming growth factor beta receptor binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0043522 leucine zipper domain binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0048185 activin binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0050998 nitric-oxide synthase binding 2/2194 11/18639 0.181818181818182 1.54462583906522 0.377731929425752 0.824446817594151 GO:0072341 modified amino acid binding 12/2194 91/18639 0.131868131868132 1.12027808108027 0.383849788200067 0.836316972166871 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:0016918 retinal binding 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:0046624 sphingolipid transporter activity 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:0050145 nucleoside monophosphate kinase activity 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:0097001 ceramide binding 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:1990380 K48-linked deubiquitinase activity 3/2194 19/18639 0.157894736842105 1.34138559708295 0.390837126667917 0.842592824742917 GO:0036002 pre-mRNA binding 8/2194 59/18639 0.135593220338983 1.15192435455711 0.392306376254617 0.843060260844094 GO:0004843 cysteine-type deubiquitinase activity 14/2194 108/18639 0.12962962962963 1.10126101488909 0.393084697006475 0.843060260844094 GO:0005516 calmodulin binding 26/2194 207/18639 0.1256038647343 1.06706036225278 0.39310852130342 0.843060260844094 GO:0004364 glutathione transferase activity 4/2194 27/18639 0.148148148148148 1.2585840170161 0.394918903856196 0.845469861994743 GO:0042277 peptide binding 31/2194 249/18639 0.124497991967871 1.0576654841792 0.397925684514384 0.850427982009039 GO:0051117 ATPase binding 11/2194 84/18639 0.130952380952381 1.11249837218388 0.401765190240539 0.857145492523577 GO:0016829 lyase activity 25/2194 200/18639 0.125 1.06193026435734 0.406122389179816 0.864942320208225 GO:0030159 signaling receptor complex adaptor activity 7/2194 52/18639 0.134615384615385 1.14361720776944 0.414162106766995 0.877283082293096 GO:0001223 transcription coactivator binding 6/2194 44/18639 0.136363636363636 1.15846937929891 0.417276592792543 0.877283082293096 GO:0045505 dynein intermediate chain binding 5/2194 36/18639 0.138888888888889 1.1799225159526 0.420231102177089 0.877283082293096 GO:0000340 RNA 7-methylguanosine cap binding 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0005527 macrolide binding 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0016208 AMP binding 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0035251 UDP-glucosyltransferase activity 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0070410 co-SMAD binding 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2194 12/18639 0.166666666666667 1.41590701914312 0.421311698575047 0.877283082293096 GO:0019789 SUMO transferase activity 4/2194 28/18639 0.142857142857143 1.21363458783696 0.422740600194668 0.877283082293096 GO:0051019 mitogen-activated protein kinase binding 4/2194 28/18639 0.142857142857143 1.21363458783696 0.422740600194668 0.877283082293096 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2194 28/18639 0.142857142857143 1.21363458783696 0.422740600194668 0.877283082293096 GO:0141052 histone H3 demethylase activity 4/2194 28/18639 0.142857142857143 1.21363458783696 0.422740600194668 0.877283082293096 GO:0042288 MHC class I protein binding 3/2194 20/18639 0.15 1.27431631722881 0.424032034089677 0.877283082293096 GO:0140939 histone H4 methyltransferase activity 3/2194 20/18639 0.15 1.27431631722881 0.424032034089677 0.877283082293096 GO:0016279 protein-lysine N-methyltransferase activity 9/2194 69/18639 0.130434782608696 1.10810114541635 0.425398148171524 0.878632752347561 GO:0008146 sulfotransferase activity 7/2194 53/18639 0.132075471698113 1.12203952460398 0.434261422412887 0.893496431493047 GO:0016860 intramolecular oxidoreductase activity 7/2194 53/18639 0.132075471698113 1.12203952460398 0.434261422412887 0.893496431493047 GO:0016779 nucleotidyltransferase activity 17/2194 136/18639 0.125 1.06193026435734 0.434772024747632 0.893496431493047 GO:0016278 lysine N-methyltransferase activity 9/2194 70/18639 0.128571428571429 1.09227112905326 0.442885043566133 0.907140580083045 GO:0016782 transferase activity, transferring sulphur-containing groups 9/2194 70/18639 0.128571428571429 1.09227112905326 0.442885043566133 0.907140580083045 GO:0019213 deacetylase activity 5/2194 37/18639 0.135135135135135 1.14803271822415 0.444453827012745 0.907334429606451 GO:0023023 MHC protein complex binding 5/2194 37/18639 0.135135135135135 1.14803271822415 0.444453827012745 0.907334429606451 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2194 29/18639 0.137931034482759 1.17178511929086 0.450234194555149 0.916096352888246 GO:0097472 cyclin-dependent protein kinase activity 4/2194 29/18639 0.137931034482759 1.17178511929086 0.450234194555149 0.916096352888246 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/2194 21/18639 0.142857142857143 1.21363458783696 0.456575012237727 0.919792554070656 GO:0008373 sialyltransferase activity 3/2194 21/18639 0.142857142857143 1.21363458783696 0.456575012237727 0.919792554070656 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2194 21/18639 0.142857142857143 1.21363458783696 0.456575012237727 0.919792554070656 GO:1904047 S-adenosyl-L-methionine binding 3/2194 21/18639 0.142857142857143 1.21363458783696 0.456575012237727 0.919792554070656 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0019104 DNA N-glycosylase activity 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0035325 Toll-like receptor binding 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0039706 co-receptor binding 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0045159 myosin II binding 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0046975 histone H3K36 methyltransferase activity 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0070123 transforming growth factor beta receptor activity, type III 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0089720 caspase binding 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0140852 histone ubiquitin ligase activity 2/2194 13/18639 0.153846153846154 1.30699109459365 0.463258638118446 0.919792554070656 GO:0030295 protein kinase activator activity 17/2194 139/18639 0.122302158273381 1.0390109061338 0.472156158175993 0.93594884173051 GO:0032452 histone demethylase activity 4/2194 30/18639 0.133333333333333 1.13272561531449 0.477291400694476 0.943091034117013 GO:0098918 structural constituent of synapse 4/2194 30/18639 0.133333333333333 1.13272561531449 0.477291400694476 0.943091034117013 GO:0008013 beta-catenin binding 13/2194 106/18639 0.122641509433962 1.04189384427512 0.481924263912578 0.950096713512268 GO:0140938 histone H3 methyltransferase activity 6/2194 47/18639 0.127659574468085 1.08452452530111 0.482380540979015 0.950096713512268 GO:0030971 receptor tyrosine kinase binding 10/2194 81/18639 0.123456790123457 1.04882001418009 0.487099063684395 0.955621948417049 GO:0016881 acid-amino acid ligase activity 3/2194 22/18639 0.136363636363636 1.15846937929891 0.488310722282896 0.955621948417049 GO:0008170 N-methyltransferase activity 12/2194 98/18639 0.122448979591837 1.04025821814596 0.488467927359181 0.955621948417049 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/2194 39/18639 0.128205128205128 1.08915924549471 0.4920469997767 0.955621948417049 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 5/2194 39/18639 0.128205128205128 1.08915924549471 0.4920469997767 0.955621948417049 GO:0004705 JUN kinase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0005313 L-glutamate transmembrane transporter activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0005344 oxygen carrier activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0005545 1-phosphatidylinositol binding 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0008174 mRNA methyltransferase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0015386 potassium:proton antiporter activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0031404 chloride ion binding 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0032454 histone H3K9 demethylase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0044548 S100 protein binding 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0061665 SUMO ligase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0098599 palmitoyl hydrolase activity 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:1901612 cardiolipin binding 2/2194 14/18639 0.142857142857143 1.21363458783696 0.503353255221469 0.955621948417049 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2194 48/18639 0.125 1.06193026435734 0.503610135580941 0.955621948417049 GO:0005164 tumor necrosis factor receptor binding 4/2194 31/18639 0.129032258064516 1.09618607933661 0.503816932999728 0.955621948417049 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/2194 31/18639 0.129032258064516 1.09618607933661 0.503816932999728 0.955621948417049 GO:0016878 acid-thiol ligase activity 4/2194 31/18639 0.129032258064516 1.09618607933661 0.503816932999728 0.955621948417049 GO:0140457 protein demethylase activity 4/2194 31/18639 0.129032258064516 1.09618607933661 0.503816932999728 0.955621948417049 GO:0004177 aminopeptidase activity 5/2194 40/18639 0.125 1.06193026435734 0.515279056983067 0.97436024446414 GO:0032451 demethylase activity 5/2194 40/18639 0.125 1.06193026435734 0.515279056983067 0.97436024446414 GO:0016493 C-C chemokine receptor activity 3/2194 23/18639 0.130434782608696 1.10810114541635 0.519111595169082 0.977104546870245 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2194 23/18639 0.130434782608696 1.10810114541635 0.519111595169082 0.977104546870245 GO:0071617 lysophospholipid acyltransferase activity 3/2194 23/18639 0.130434782608696 1.10810114541635 0.519111595169082 0.977104546870245 GO:0030246 carbohydrate binding 33/2194 280/18639 0.117857142857143 1.00124853496549 0.524975295088856 0.986632959166996 GO:0052689 carboxylic ester hydrolase activity 11/2194 92/18639 0.119565217391304 1.01575938329832 0.526140172005522 0.987314865455485 GO:0044183 protein folding chaperone 9/2194 75/18639 0.12 1.01945305378304 0.528712847964733 0.988023318669316 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/2194 32/18639 0.125 1.06193026435734 0.529728180602558 0.988023318669316 GO:0043425 bHLH transcription factor binding 4/2194 32/18639 0.125 1.06193026435734 0.529728180602558 0.988023318669316 GO:0070717 poly-purine tract binding 4/2194 32/18639 0.125 1.06193026435734 0.529728180602558 0.988023318669316 GO:0008408 3'-5' exonuclease activity 7/2194 58/18639 0.120689655172414 1.0253119793795 0.532353087596927 0.991417020925594 GO:0042054 histone methyltransferase activity 8/2194 67/18639 0.119402985074627 1.01438114804283 0.539213933234975 0.997792400501291 GO:0000774 adenyl-nucleotide exchange factor activity 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0010181 FMN binding 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0050780 dopamine receptor binding 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0061578 K63-linked deubiquitinase activity 2/2194 15/18639 0.133333333333333 1.13272561531449 0.541450303440181 0.997792400501291 GO:0015605 organophosphate ester transmembrane transporter activity 6/2194 50/18639 0.12 1.01945305378304 0.545063732432642 0.999999999998594 GO:0004622 lysophospholipase activity 3/2194 24/18639 0.125 1.06193026435734 0.548875545673971 0.999999999998594 GO:0004806 triacylglycerol lipase activity 3/2194 24/18639 0.125 1.06193026435734 0.548875545673971 0.999999999998594 GO:0019957 C-C chemokine binding 3/2194 24/18639 0.125 1.06193026435734 0.548875545673971 0.999999999998594 GO:0004879 nuclear receptor activity 7/2194 59/18639 0.11864406779661 1.00793381023747 0.551205529508392 0.999999999998594 GO:0070888 E-box binding 7/2194 59/18639 0.11864406779661 1.00793381023747 0.551205529508392 0.999999999998594 GO:1902936 phosphatidylinositol bisphosphate binding 13/2194 111/18639 0.117117117117117 0.994961689127596 0.551817772369561 0.999999999998594 GO:0016853 isomerase activity 21/2194 180/18639 0.116666666666667 0.991134913400182 0.552178221052251 0.999999999998594 GO:0019894 kinesin binding 5/2194 42/18639 0.119047619047619 1.0113621565308 0.560321381645291 0.999999999998594 GO:0051879 Hsp90 protein binding 5/2194 42/18639 0.119047619047619 1.0113621565308 0.560321381645291 0.999999999998594 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/2194 86/18639 0.116279069767442 0.987842106378919 0.566449081554063 0.999999999998594 GO:0004540 RNA nuclease activity 14/2194 121/18639 0.115702479338843 0.982943715768776 0.569656939240131 0.999999999998594 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 7/2194 60/18639 0.116666666666667 0.991134913400182 0.569721926460911 0.999999999998594 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2194 60/18639 0.116666666666667 0.991134913400182 0.569721926460911 0.999999999998594 GO:0098531 ligand-modulated transcription factor activity 7/2194 60/18639 0.116666666666667 0.991134913400182 0.569721926460911 0.999999999998594 GO:0140375 immune receptor activity 18/2194 156/18639 0.115384615384615 0.980243320945235 0.573346683560729 0.999999999998594 GO:0004707 MAP kinase activity 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0005024 transforming growth factor beta receptor activity 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0005149 interleukin-1 receptor binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0005159 insulin-like growth factor receptor binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0005521 lamin binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0015385 sodium:proton antiporter activity 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0015923 mannosidase activity 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0016722 oxidoreductase activity, acting on metal ions 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0019841 retinol binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0022858 alanine transmembrane transporter activity 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0070411 I-SMAD binding 2/2194 16/18639 0.125 1.06193026435734 0.577464357674916 0.999999999998594 GO:0004709 MAP kinase kinase kinase activity 3/2194 25/18639 0.12 1.01945305378304 0.577523593324241 0.999999999998594 GO:0005537 D-mannose binding 3/2194 25/18639 0.12 1.01945305378304 0.577523593324241 0.999999999998594 GO:0042974 nuclear retinoic acid receptor binding 3/2194 25/18639 0.12 1.01945305378304 0.577523593324241 0.999999999998594 GO:0120020 cholesterol transfer activity 3/2194 25/18639 0.12 1.01945305378304 0.577523593324241 0.999999999998594 GO:0140767 enzyme-substrate adaptor activity 16/2194 139/18639 0.115107913669065 0.977892617537693 0.577523945741388 0.999999999998594 GO:0051427 hormone receptor binding 4/2194 34/18639 0.117647058823529 0.999463778218671 0.579437730965067 0.999999999998594 GO:0061134 peptidase regulator activity 26/2194 226/18639 0.115044247787611 0.977351747727108 0.580876739689205 0.999999999998594 GO:0019209 kinase activator activity 17/2194 148/18639 0.114864864864865 0.975827810490527 0.581194410728308 0.999999999998594 GO:0008081 phosphoric diester hydrolase activity 10/2194 87/18639 0.114942528735632 0.976487599409047 0.581718368350483 0.999999999998594 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/2194 43/18639 0.116279069767442 0.987842106378919 0.582035419968105 0.999999999998594 GO:0015026 coreceptor activity 7/2194 61/18639 0.114754098360656 0.974886800065753 0.587873888882384 0.999999999998594 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 7/2194 61/18639 0.114754098360656 0.974886800065753 0.587873888882384 0.999999999998594 GO:0033293 monocarboxylic acid binding 9/2194 79/18639 0.113924050632911 0.967835177642131 0.593823911530403 0.999999999998594 GO:0046332 SMAD binding 9/2194 79/18639 0.113924050632911 0.967835177642131 0.593823911530403 0.999999999998594 GO:0005154 epidermal growth factor receptor binding 4/2194 35/18639 0.114285714285714 0.970907670269566 0.603129265593714 0.999999999998594 GO:0016229 steroid dehydrogenase activity 4/2194 35/18639 0.114285714285714 0.970907670269566 0.603129265593714 0.999999999998594 GO:0043015 gamma-tubulin binding 4/2194 35/18639 0.114285714285714 0.970907670269566 0.603129265593714 0.999999999998594 GO:0016790 thiolester hydrolase activity 5/2194 44/18639 0.113636363636364 0.965391149415762 0.603158346529074 0.999999999998594 GO:1901505 carbohydrate derivative transmembrane transporter activity 6/2194 53/18639 0.113207547169811 0.961748163946269 0.604136367915235 0.999999999998594 GO:0001637 G protein-coupled chemoattractant receptor activity 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0004950 chemokine receptor activity 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0008143 poly(A) binding 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0030507 spectrin binding 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0051139 metal cation:proton antiporter activity 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0052742 phosphatidylinositol kinase activity 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0070006 metalloaminopeptidase activity 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0070412 R-SMAD binding 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0097602 cullin family protein binding 3/2194 26/18639 0.115384615384615 0.980243320945235 0.604997472648381 0.999999999998594 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 26/2194 229/18639 0.11353711790393 0.964548013040726 0.608957997177214 0.999999999998594 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0008484 sulfuric ester hydrolase activity 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0030169 low-density lipoprotein particle binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0038191 neuropilin binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0045125 bioactive lipid receptor activity 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0045236 CXCR chemokine receptor binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0046965 nuclear retinoid X receptor binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0048038 quinone binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0070402 NADPH binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0070403 NAD+ binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0070492 oligosaccharide binding 2/2194 17/18639 0.117647058823529 0.999463778218671 0.611357754020278 0.999999999998594 GO:0050661 NADP binding 6/2194 54/18639 0.111111111111111 0.943938012762078 0.622870962208974 0.999999999998594 GO:1901682 sulfur compound transmembrane transporter activity 7/2194 63/18639 0.111111111111111 0.943938012762078 0.62298629874617 0.999999999998594 GO:0042379 chemokine receptor binding 8/2194 72/18639 0.111111111111111 0.943938012762078 0.623665079100633 0.999999999998594 GO:0001618 virus receptor activity 9/2194 81/18639 0.111111111111111 0.943938012762078 0.624711849595142 0.999999999998594 GO:0008266 poly(U) RNA binding 3/2194 27/18639 0.111111111111111 0.943938012762078 0.631257293747404 0.999999999998594 GO:0019955 cytokine binding 16/2194 144/18639 0.111111111111111 0.943938012762078 0.635995824063503 0.999999999998594 GO:0140272 exogenous protein binding 9/2194 82/18639 0.109756097560976 0.932426573582053 0.639680254679424 0.999999999998594 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0004706 JUN kinase kinase kinase activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0008308 voltage-gated monoatomic anion channel activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0008409 5'-3' exonuclease activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0016854 racemase and epimerase activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0017075 syntaxin-1 binding 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0032393 MHC class I receptor activity 2/2194 18/18639 0.111111111111111 0.943938012762078 0.643130538003011 0.999999999998594 GO:0070001 aspartic-type peptidase activity 4/2194 37/18639 0.108108108108108 0.91842617457932 0.647996106809646 0.999999999998594 GO:0035064 methylated histone binding 8/2194 74/18639 0.108108108108108 0.91842617457932 0.654997280322687 0.999999999998594 GO:0050698 proteoglycan sulfotransferase activity 3/2194 28/18639 0.107142857142857 0.910225940877718 0.656279296973733 0.999999999998594 GO:0051959 dynein light intermediate chain binding 3/2194 28/18639 0.107142857142857 0.910225940877718 0.656279296973733 0.999999999998594 GO:0097718 disordered domain specific binding 3/2194 28/18639 0.107142857142857 0.910225940877718 0.656279296973733 0.999999999998594 GO:0160215 deacylase activity 7/2194 65/18639 0.107692307692308 0.914893766215553 0.656376099214433 0.999999999998594 GO:0042887 amide transmembrane transporter activity 4/2194 38/18639 0.105263157894737 0.894257064721969 0.669123094394958 0.999999999998594 GO:0043531 ADP binding 4/2194 38/18639 0.105263157894737 0.894257064721969 0.669123094394958 0.999999999998594 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0022821 solute:potassium antiporter activity 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0034987 immunoglobulin receptor binding 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0042577 lipid phosphatase activity 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0042800 histone H3K4 methyltransferase activity 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0046527 glucosyltransferase activity 2/2194 19/18639 0.105263157894737 0.894257064721969 0.67281211580714 0.999999999998594 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2194 57/18639 0.105263157894737 0.894257064721969 0.675890372506467 0.999999999998594 GO:0004629 phospholipase C activity 3/2194 29/18639 0.103448275862069 0.878838839468142 0.680053731868185 0.999999999998594 GO:0043236 laminin binding 3/2194 29/18639 0.103448275862069 0.878838839468142 0.680053731868185 0.999999999998594 GO:0140034 methylation-dependent protein binding 8/2194 76/18639 0.105263157894737 0.894257064721969 0.684748604337128 0.999999999998594 GO:0050840 extracellular matrix binding 7/2194 67/18639 0.104477611940299 0.887583504537477 0.687922166173858 0.999999999998594 GO:0000217 DNA secondary structure binding 4/2194 39/18639 0.102564102564103 0.871327396395765 0.689360362351331 0.999999999998594 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 18/2194 167/18639 0.107784431137725 0.915676395613513 0.690693183025174 0.999999999998594 GO:0005126 cytokine receptor binding 30/2194 275/18639 0.109090909090909 0.926775503439132 0.699964013852565 0.999999999998594 GO:0030742 GTP-dependent protein binding 2/2194 20/18639 0.1 0.849544211485871 0.70045434710908 0.999999999998594 GO:0008168 methyltransferase activity 22/2194 204/18639 0.107843137254902 0.916175130033782 0.70176548177161 0.999999999998594 GO:0001965 G-protein alpha-subunit binding 3/2194 30/18639 0.1 0.849544211485871 0.702582879776374 0.999999999998594 GO:0008187 poly-pyrimidine tract binding 3/2194 30/18639 0.1 0.849544211485871 0.702582879776374 0.999999999998594 GO:0048019 receptor antagonist activity 3/2194 30/18639 0.1 0.849544211485871 0.702582879776374 0.999999999998594 GO:0004896 cytokine receptor activity 10/2194 96/18639 0.104166666666667 0.884941886964449 0.706618626517517 0.999999999998594 GO:0015459 potassium channel regulator activity 6/2194 59/18639 0.101694915254237 0.863943265917835 0.708442574927866 0.999999999998594 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0004090 carbonyl reductase (NADPH) activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0004955 prostaglandin receptor activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0008190 eukaryotic initiation factor 4E binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0008519 ammonium channel activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0015187 glycine transmembrane transporter activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0015643 toxic substance binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0016427 tRNA (cytidine) methyltransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0016783 sulfurtransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0016868 intramolecular phosphotransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0030957 Tat protein binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0031419 cobalamin binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0032356 oxidized DNA binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0033204 ribonuclease P RNA binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0035256 G protein-coupled glutamate receptor binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0035374 chondroitin sulfate binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0042975 peroxisome proliferator activated receptor binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0043121 neurotrophin binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0043422 protein kinase B binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0050308 sugar-phosphatase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0070739 protein-glutamic acid ligase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0070740 tubulin-glutamic acid ligase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0140940 histone H2A methyltransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0140999 histone H3K4 trimethyltransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:1990259 histone H2AQ104 methyltransferase activity 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:1990763 arrestin family protein binding 1/2194 10/18639 0.1 0.849544211485871 0.714258870400363 0.999999999998594 GO:0008327 methyl-CpG binding 3/2194 31/18639 0.0967741935483871 0.822139559502455 0.723879231216729 0.999999999998594 GO:0016411 acylglycerol O-acyltransferase activity 3/2194 31/18639 0.0967741935483871 0.822139559502455 0.723879231216729 0.999999999998594 GO:0072349 modified amino acid transmembrane transporter activity 3/2194 31/18639 0.0967741935483871 0.822139559502455 0.723879231216729 0.999999999998594 GO:0015125 bile acid transmembrane transporter activity 2/2194 21/18639 0.0952380952380952 0.809089725224639 0.726125856042907 0.999999999998594 GO:0019200 carbohydrate kinase activity 2/2194 21/18639 0.0952380952380952 0.809089725224639 0.726125856042907 0.999999999998594 GO:0061891 calcium ion sensor activity 2/2194 21/18639 0.0952380952380952 0.809089725224639 0.726125856042907 0.999999999998594 GO:0001727 lipid kinase activity 4/2194 41/18639 0.0975609756097561 0.828823620961825 0.727151202108393 0.999999999998594 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/2194 41/18639 0.0975609756097561 0.828823620961825 0.727151202108393 0.999999999998594 GO:0004175 endopeptidase activity 44/2194 405/18639 0.108641975308642 0.922961612478477 0.738717911838335 0.999999999998594 GO:0019838 growth factor binding 14/2194 136/18639 0.102941176470588 0.874530805941337 0.74247372364643 0.999999999998594 GO:0030515 snoRNA binding 3/2194 32/18639 0.09375 0.796447698268004 0.743963822659575 0.999999999998594 GO:0008307 structural constituent of muscle 4/2194 42/18639 0.0952380952380952 0.809089725224639 0.744712235841351 0.999999999998594 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0004954 prostanoid receptor activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0005225 volume-sensitive anion channel activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0008172 S-methyltransferase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0008199 ferric iron binding 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0010854 adenylate cyclase regulator activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0015217 ADP transmembrane transporter activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0019203 carbohydrate phosphatase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0019215 intermediate filament binding 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0032794 GTPase activating protein binding 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0045294 alpha-catenin binding 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0048407 platelet-derived growth factor binding 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0180030 inositol phosphate kinase activity 1/2194 11/18639 0.0909090909090909 0.77231291953261 0.747911564497824 0.999999999998594 GO:0008093 cytoskeletal anchor activity 2/2194 22/18639 0.0909090909090909 0.77231291953261 0.749907369418908 0.999999999998594 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/2194 22/18639 0.0909090909090909 0.77231291953261 0.749907369418908 0.999999999998594 GO:0033691 sialic acid binding 2/2194 22/18639 0.0909090909090909 0.77231291953261 0.749907369418908 0.999999999998594 GO:0140784 metal ion sensor activity 2/2194 22/18639 0.0909090909090909 0.77231291953261 0.749907369418908 0.999999999998594 GO:0015179 L-amino acid transmembrane transporter activity 6/2194 62/18639 0.0967741935483871 0.822139559502455 0.752946206256464 0.999999999998594 GO:0015085 calcium ion transmembrane transporter activity 15/2194 147/18639 0.102040816326531 0.86688184845497 0.759461626091224 0.999999999998594 GO:0019239 deaminase activity 3/2194 33/18639 0.0909090909090909 0.77231291953261 0.762864732532246 0.999999999998594 GO:0030296 protein tyrosine kinase activator activity 3/2194 33/18639 0.0909090909090909 0.77231291953261 0.762864732532246 0.999999999998594 GO:0042923 neuropeptide binding 3/2194 33/18639 0.0909090909090909 0.77231291953261 0.762864732532246 0.999999999998594 GO:1901681 sulfur compound binding 29/2194 275/18639 0.105454545454545 0.895882986657827 0.763816712892374 0.999999999998594 GO:0070851 growth factor receptor binding 14/2194 139/18639 0.100719424460432 0.855656040345481 0.770859116643411 0.999999999998594 GO:0000295 adenine nucleotide transmembrane transporter activity 2/2194 23/18639 0.0869565217391304 0.738734096944235 0.771887919347463 0.999999999998594 GO:0016849 phosphorus-oxygen lyase activity 2/2194 23/18639 0.0869565217391304 0.738734096944235 0.771887919347463 0.999999999998594 GO:0017134 fibroblast growth factor binding 2/2194 23/18639 0.0869565217391304 0.738734096944235 0.771887919347463 0.999999999998594 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 13/2194 130/18639 0.1 0.849544211485871 0.773678882625383 0.999999999998594 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0003720 telomerase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0004000 adenosine deaminase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0004126 cytidine deaminase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0004526 ribonuclease P activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0004859 phospholipase inhibitor activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0005025 transforming growth factor beta receptor activity, type I 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0005026 transforming growth factor beta receptor activity, type II 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0005165 neurotrophin receptor binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0005436 sodium:phosphate symporter activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0008179 adenylate cyclase binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0008504 monoamine transmembrane transporter activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0010853 cyclase activator activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0015132 prostaglandin transmembrane transporter activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0015368 calcium:monoatomic cation antiporter activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016361 activin receptor activity, type I 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016362 activin receptor activity, type II 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016801 hydrolase activity, acting on ether bonds 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016803 ether hydrolase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016840 carbon-nitrogen lyase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0017002 activin receptor activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0035259 nuclear glucocorticoid receptor binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0036009 protein-glutamine N-methyltransferase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0042301 phosphate ion binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0045295 gamma-catenin binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0070008 serine-type exopeptidase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0070679 inositol 1,4,5 trisphosphate binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0097677 STAT family protein binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:1990459 transferrin receptor binding 1/2194 12/18639 0.0833333333333333 0.707953509571559 0.777602461399895 0.999999999998594 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/2194 34/18639 0.0882352941176471 0.749597833664003 0.780615732683909 0.999999999998594 GO:0005262 calcium channel activity 13/2194 131/18639 0.099236641221374 0.843059141169185 0.782863555528536 0.999999999998594 GO:0003678 DNA helicase activity 7/2194 74/18639 0.0945945945945946 0.803622902756905 0.782997634476496 0.999999999998594 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 12/2194 122/18639 0.0983606557377049 0.835617257199217 0.786405523082983 0.999999999998594 GO:0004527 exonuclease activity 8/2194 84/18639 0.0952380952380952 0.809089725224639 0.786857561104608 0.999999999998594 GO:0016741 transferase activity, transferring one-carbon groups 22/2194 215/18639 0.102325581395349 0.869301053613449 0.788586853860567 0.999999999998594 GO:0098632 cell-cell adhesion mediator activity 5/2194 55/18639 0.0909090909090909 0.77231291953261 0.791168585577392 0.999999999998594 GO:0005540 hyaluronic acid binding 2/2194 24/18639 0.0833333333333333 0.707953509571559 0.792161771499598 0.999999999998594 GO:0015295 solute:proton symporter activity 2/2194 24/18639 0.0833333333333333 0.707953509571559 0.792161771499598 0.999999999998594 GO:0050431 transforming growth factor beta binding 2/2194 24/18639 0.0833333333333333 0.707953509571559 0.792161771499598 0.999999999998594 GO:0005343 organic acid:sodium symporter activity 3/2194 35/18639 0.0857142857142857 0.728180752702175 0.797255088973614 0.999999999998594 GO:0003964 RNA-directed DNA polymerase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0004465 lipoprotein lipase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0008417 fucosyltransferase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0009982 pseudouridine synthase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0017154 semaphorin receptor activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0035673 oligopeptide transmembrane transporter activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0046974 histone H3K9 methyltransferase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0070700 BMP receptor binding 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0071714 icosanoid transmembrane transporter activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0071837 HMG box domain binding 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0097157 pre-mRNA intronic binding 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2194 13/18639 0.0769230769230769 0.653495547296824 0.803797780006683 0.999999999998594 GO:0008235 metalloexopeptidase activity 6/2194 66/18639 0.0909090909090909 0.77231291953261 0.804269752580889 0.999999999998594 GO:0000030 mannosyltransferase activity 2/2194 25/18639 0.08 0.679635369188696 0.810825960906151 0.999999999998594 GO:0015662 P-type ion transporter activity 2/2194 25/18639 0.08 0.679635369188696 0.810825960906151 0.999999999998594 GO:0047617 fatty acyl-CoA hydrolase activity 2/2194 25/18639 0.08 0.679635369188696 0.810825960906151 0.999999999998594 GO:0140358 P-type transmembrane transporter activity 2/2194 25/18639 0.08 0.679635369188696 0.810825960906151 0.999999999998594 GO:0004190 aspartic-type endopeptidase activity 3/2194 36/18639 0.0833333333333333 0.707953509571559 0.812824502878417 0.999999999998594 GO:0016409 palmitoyltransferase activity 3/2194 36/18639 0.0833333333333333 0.707953509571559 0.812824502878417 0.999999999998594 GO:0008173 RNA methyltransferase activity 6/2194 67/18639 0.0895522388059701 0.760785861032123 0.815713777473384 0.999999999998594 GO:0015297 antiporter activity 13/2194 135/18639 0.0962962962962963 0.818079611060468 0.816961588719629 0.999999999998594 GO:0061749 forked DNA-dependent helicase activity 4/2194 47/18639 0.0851063829787234 0.723016350200741 0.819728751302306 0.999999999998594 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/2194 47/18639 0.0851063829787234 0.723016350200741 0.819728751302306 0.999999999998594 GO:0030145 manganese ion binding 6/2194 68/18639 0.0882352941176471 0.749597833664003 0.826623737799707 0.999999999998594 GO:0004065 arylsulfatase activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0005347 ATP transmembrane transporter activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0008191 metalloendopeptidase inhibitor activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0008195 phosphatidate phosphatase activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0008494 translation activator activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0030983 mismatched DNA binding 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0070742 C2H2 zinc finger domain binding 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0098821 BMP receptor activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:1901474 azole transmembrane transporter activity 1/2194 14/18639 0.0714285714285714 0.606817293918479 0.826908897297853 0.999999999998594 GO:0022829 wide pore channel activity 3/2194 37/18639 0.0810810810810811 0.68881963093449 0.827368184884484 0.999999999998594 GO:0030280 structural constituent of skin epidermis 3/2194 37/18639 0.0810810810810811 0.68881963093449 0.827368184884484 0.999999999998594 GO:0004435 phosphatidylinositol phospholipase C activity 2/2194 26/18639 0.0769230769230769 0.653495547296824 0.827978334927632 0.999999999998594 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2194 26/18639 0.0769230769230769 0.653495547296824 0.827978334927632 0.999999999998594 GO:0015216 purine nucleotide transmembrane transporter activity 2/2194 26/18639 0.0769230769230769 0.653495547296824 0.827978334927632 0.999999999998594 GO:0016289 acyl-CoA hydrolase activity 2/2194 26/18639 0.0769230769230769 0.653495547296824 0.827978334927632 0.999999999998594 GO:0042626 ATPase-coupled transmembrane transporter activity 9/2194 98/18639 0.0918367346938776 0.780193663609473 0.829471108368532 0.999999999998594 GO:0061135 endopeptidase regulator activity 18/2194 184/18639 0.0978260869565217 0.831075859062265 0.830084476581402 0.999999999998594 GO:0009378 four-way junction helicase activity 4/2194 48/18639 0.0833333333333333 0.707953509571559 0.832323246949624 0.999999999998594 GO:0036121 double-stranded DNA helicase activity 4/2194 48/18639 0.0833333333333333 0.707953509571559 0.832323246949624 0.999999999998594 GO:0043138 3'-5' DNA helicase activity 4/2194 48/18639 0.0833333333333333 0.707953509571559 0.832323246949624 0.999999999998594 GO:0004620 phospholipase activity 10/2194 109/18639 0.0917431192660551 0.779398359161349 0.839924297617538 0.999999999998594 GO:0005501 retinoid binding 3/2194 38/18639 0.0789473684210526 0.670692798541477 0.840932049783587 0.999999999998594 GO:0019840 isoprenoid binding 3/2194 38/18639 0.0789473684210526 0.670692798541477 0.840932049783587 0.999999999998594 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/2194 27/18639 0.0740740740740741 0.629292008508052 0.84371601822205 0.999999999998594 GO:0023026 MHC class II protein complex binding 2/2194 27/18639 0.0740740740740741 0.629292008508052 0.84371601822205 0.999999999998594 GO:0035254 glutamate receptor binding 4/2194 49/18639 0.0816326530612245 0.693505478763976 0.844174849588129 0.999999999998594 GO:0008028 monocarboxylic acid transmembrane transporter activity 6/2194 70/18639 0.0857142857142857 0.728180752702175 0.846892545710035 0.999999999998594 GO:0004089 carbonate dehydratase activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0004559 alpha-mannosidase activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0004953 icosanoid receptor activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0005041 low-density lipoprotein particle receptor activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0015116 sulfate transmembrane transporter activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0015929 hexosaminidase activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0016846 carbon-sulfur lyase activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0030553 cGMP binding 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0031005 filamin binding 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0033130 acetylcholine receptor binding 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0045504 dynein heavy chain binding 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0047372 monoacylglycerol lipase activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0051371 muscle alpha-actinin binding 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0140161 monocarboxylate:sodium symporter activity 1/2194 15/18639 0.0666666666666667 0.566362807657247 0.847298796859115 0.999999999998594 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 5/2194 60/18639 0.0833333333333333 0.707953509571559 0.849762103159927 0.999999999998594 GO:0140597 protein carrier chaperone 18/2194 188/18639 0.0957446808510638 0.813393393975833 0.854907916978964 0.999999999998594 GO:0030414 peptidase inhibitor activity 16/2194 169/18639 0.0946745562130177 0.804302212057629 0.855072388514356 0.999999999998594 GO:0048020 CCR chemokine receptor binding 4/2194 50/18639 0.08 0.679635369188696 0.85531214626505 0.999999999998594 GO:0016866 intramolecular transferase activity 2/2194 28/18639 0.0714285714285714 0.606817293918479 0.858134227548844 0.999999999998594 GO:0008238 exopeptidase activity 9/2194 102/18639 0.0882352941176471 0.749597833664003 0.86218594032716 0.999999999998594 GO:0015378 sodium:chloride symporter activity 1/2194 16/18639 0.0625 0.530965132178669 0.865287759471395 0.999999999998594 GO:0015562 efflux transmembrane transporter activity 1/2194 16/18639 0.0625 0.530965132178669 0.865287759471395 0.999999999998594 GO:0055102 lipase inhibitor activity 1/2194 16/18639 0.0625 0.530965132178669 0.865287759471395 0.999999999998594 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/2194 40/18639 0.075 0.637158158614403 0.865308452989394 0.999999999998594 GO:0140662 ATP-dependent protein folding chaperone 3/2194 40/18639 0.075 0.637158158614403 0.865308452989394 0.999999999998594 GO:0016597 amino acid binding 4/2194 51/18639 0.0784313725490196 0.666309185479114 0.865764480132416 0.999999999998594 GO:0051213 dioxygenase activity 8/2194 93/18639 0.0860215053763441 0.730790719557738 0.869901308200423 0.999999999998594 GO:0004181 metallocarboxypeptidase activity 2/2194 29/18639 0.0689655172413793 0.585892559645428 0.871325375377041 0.999999999998594 GO:0016417 S-acyltransferase activity 2/2194 29/18639 0.0689655172413793 0.585892559645428 0.871325375377041 0.999999999998594 GO:0035250 UDP-galactosyltransferase activity 2/2194 29/18639 0.0689655172413793 0.585892559645428 0.871325375377041 0.999999999998594 GO:0106222 lncRNA binding 2/2194 29/18639 0.0689655172413793 0.585892559645428 0.871325375377041 0.999999999998594 GO:0004521 RNA endonuclease activity 6/2194 73/18639 0.0821917808219178 0.698255516289757 0.8736316122071 0.999999999998594 GO:0001530 lipopolysaccharide binding 3/2194 41/18639 0.0731707317073171 0.621617715721369 0.876215604374736 0.999999999998594 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2194 41/18639 0.0731707317073171 0.621617715721369 0.876215604374736 0.999999999998594 GO:0004549 tRNA-specific ribonuclease activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0004550 nucleoside diphosphate kinase activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0009881 photoreceptor activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0015278 intracellularly gated calcium channel activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0016805 dipeptidase activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0017110 nucleoside diphosphate phosphatase activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/2194 17/18639 0.0588235294117647 0.499731889109336 0.88115838481209 0.999999999998594 GO:0048029 monosaccharide binding 6/2194 74/18639 0.0810810810810811 0.68881963093449 0.881628727889212 0.999999999998594 GO:0015215 nucleotide transmembrane transporter activity 2/2194 30/18639 0.0666666666666667 0.566362807657247 0.883378410777089 0.999999999998594 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/2194 30/18639 0.0666666666666667 0.566362807657247 0.883378410777089 0.999999999998594 GO:0004386 helicase activity 14/2194 155/18639 0.0903225806451613 0.767330255535625 0.885709956773903 0.999999999998594 GO:0004520 DNA endonuclease activity 3/2194 42/18639 0.0714285714285714 0.606817293918479 0.886331248108073 0.999999999998594 GO:0038024 cargo receptor activity 5/2194 65/18639 0.0769230769230769 0.653495547296824 0.894012836693094 0.999999999998594 GO:0005452 solute:inorganic anion antiporter activity 2/2194 31/18639 0.0645161290322581 0.548093039668304 0.894378354195044 0.999999999998594 GO:0003746 translation elongation factor activity 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0005372 water transmembrane transporter activity 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0015373 monoatomic anion:sodium symporter activity 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0017128 phospholipid scramblase activity 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0030228 lipoprotein particle receptor activity 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0034185 apolipoprotein binding 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0050811 GABA receptor binding 1/2194 18/18639 0.0555555555555556 0.471969006381039 0.895160022859683 0.999999999998594 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/2194 43/18639 0.0697674418604651 0.592705263827352 0.895701313905976 0.999999999998594 GO:0008374 O-acyltransferase activity 4/2194 55/18639 0.0727272727272727 0.617850335626088 0.90132144398797 0.999999999998594 GO:0003724 RNA helicase activity 6/2194 77/18639 0.0779220779220779 0.661982502456523 0.903097510448542 0.999999999998594 GO:0030547 signaling receptor inhibitor activity 3/2194 44/18639 0.0681818181818182 0.579234689649457 0.904370612004212 0.999999999998594 GO:0008378 galactosyltransferase activity 2/2194 32/18639 0.0625 0.530965132178669 0.904405989630742 0.999999999998594 GO:0071813 lipoprotein particle binding 2/2194 32/18639 0.0625 0.530965132178669 0.904405989630742 0.999999999998594 GO:0071814 protein-lipid complex binding 2/2194 32/18639 0.0625 0.530965132178669 0.904405989630742 0.999999999998594 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0008301 DNA binding, bending 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0030506 ankyrin binding 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0141147 intracellularly calcium-gated channel activity 1/2194 19/18639 0.0526315789473684 0.447128532360984 0.907512684362602 0.999999999998594 GO:0030170 pyridoxal phosphate binding 4/2194 56/18639 0.0714285714285714 0.606817293918479 0.908796219480466 0.999999999998594 GO:0170055 lipid transmembrane transporter activity 4/2194 56/18639 0.0714285714285714 0.606817293918479 0.908796219480466 0.999999999998594 GO:0019842 vitamin binding 13/2194 150/18639 0.0866666666666667 0.736271649954421 0.909945541719966 0.999999999998594 GO:0016298 lipase activity 11/2194 130/18639 0.0846153846153846 0.718845102026506 0.91034825119311 0.999999999998594 GO:0140416 transcription regulator inhibitor activity 2/2194 33/18639 0.0606060606060606 0.514875279688406 0.913537683637097 0.999999999998594 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/2194 268/18639 0.0932835820895522 0.792485271908461 0.914314370794195 0.999999999998594 GO:0004866 endopeptidase inhibitor activity 14/2194 161/18639 0.0869565217391304 0.738734096944235 0.914508292254575 0.999999999998594 GO:0008186 ATP-dependent activity, acting on RNA 6/2194 79/18639 0.0759493670886076 0.645223451761421 0.915471249111912 0.999999999998594 GO:0015370 solute:sodium symporter activity 6/2194 79/18639 0.0759493670886076 0.645223451761421 0.915471249111912 0.999999999998594 GO:0001664 G protein-coupled receptor binding 28/2194 297/18639 0.0942760942760943 0.800917101737521 0.915553986010263 0.999999999998594 GO:0070279 vitamin B6 binding 4/2194 57/18639 0.0701754385964912 0.596171376481313 0.915763333570657 0.999999999998594 GO:0001614 purinergic nucleotide receptor activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0005326 neurotransmitter transmembrane transporter activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0010851 cyclase regulator activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0015095 magnesium ion transmembrane transporter activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0016502 nucleotide receptor activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0030627 pre-mRNA 5'-splice site binding 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0031418 L-ascorbic acid binding 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0140664 ATP-dependent DNA damage sensor activity 1/2194 20/18639 0.05 0.424772105742935 0.918410491586471 0.999999999998594 GO:0046906 tetrapyrrole binding 13/2194 152/18639 0.0855263157894737 0.7265838650866 0.918698536635728 0.999999999998594 GO:0020037 heme binding 12/2194 142/18639 0.0845070422535211 0.717924685762708 0.919001678705608 0.999999999998594 GO:0004180 carboxypeptidase activity 3/2194 46/18639 0.0652173913043478 0.554050572708176 0.919779267197091 0.999999999998594 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/2194 46/18639 0.0652173913043478 0.554050572708176 0.919779267197091 0.999999999998594 GO:0008175 tRNA methyltransferase activity 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0016831 carboxy-lyase activity 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0019825 oxygen binding 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0090482 vitamin transmembrane transporter activity 2/2194 34/18639 0.0588235294117647 0.499731889109336 0.921845305571671 0.999999999998594 GO:0017116 single-stranded DNA helicase activity 4/2194 58/18639 0.0689655172413793 0.585892559645428 0.922250775865954 0.999999999998594 GO:0015101 organic cation transmembrane transporter activity 6/2194 81/18639 0.0740740740740741 0.629292008508052 0.926445005520089 0.999999999998594 GO:0008237 metallopeptidase activity 16/2194 184/18639 0.0869565217391304 0.738734096944235 0.926598968097331 0.999999999998594 GO:0005506 iron ion binding 13/2194 154/18639 0.0844155844155844 0.717147710994566 0.926725602437264 0.999999999998594 GO:0009975 cyclase activity 1/2194 21/18639 0.0476190476190476 0.404544862612319 0.92802472336365 0.999999999998594 GO:0015174 basic amino acid transmembrane transporter activity 1/2194 21/18639 0.0476190476190476 0.404544862612319 0.92802472336365 0.999999999998594 GO:0036122 BMP binding 1/2194 21/18639 0.0476190476190476 0.404544862612319 0.92802472336365 0.999999999998594 GO:0051428 peptide hormone receptor binding 1/2194 21/18639 0.0476190476190476 0.404544862612319 0.92802472336365 0.999999999998594 GO:0070182 DNA polymerase binding 1/2194 21/18639 0.0476190476190476 0.404544862612319 0.92802472336365 0.999999999998594 GO:0034061 DNA polymerase activity 2/2194 35/18639 0.0571428571428571 0.485453835134783 0.929396227789735 0.999999999998594 GO:0140299 molecular sensor activity 5/2194 71/18639 0.0704225352112676 0.598270571468923 0.931839362431048 0.999999999998594 GO:0008188 neuropeptide receptor activity 3/2194 48/18639 0.0625 0.530965132178669 0.932886069702907 0.999999999998594 GO:0016887 ATP hydrolysis activity 40/2194 417/18639 0.0959232613908873 0.814910514614744 0.932923897405035 0.999999999998594 GO:0004033 aldo-keto reductase (NADPH) activity 2/2194 36/18639 0.0555555555555556 0.471969006381039 0.936253388078636 0.999999999998594 GO:0008649 rRNA methyltransferase activity 1/2194 22/18639 0.0454545454545455 0.386156459766305 0.936506502122923 0.999999999998594 GO:0015377 chloride:monoatomic cation symporter activity 1/2194 22/18639 0.0454545454545455 0.386156459766305 0.936506502122923 0.999999999998594 GO:0042562 hormone binding 7/2194 94/18639 0.074468085106383 0.632639306425648 0.93651325424543 0.999999999998594 GO:0031406 carboxylic acid binding 16/2194 187/18639 0.0855614973262032 0.726882747795397 0.936595587450512 0.999999999998594 GO:0016758 hexosyltransferase activity 17/2194 197/18639 0.0862944162436548 0.733109218033492 0.936645846069082 0.999999999998594 GO:0016763 pentosyltransferase activity 3/2194 49/18639 0.0612244897959184 0.520129109072982 0.938671584058219 0.999999999998594 GO:0017171 serine hydrolase activity 17/2194 198/18639 0.0858585858585859 0.729406646225242 0.939636844274281 0.999999999998594 GO:0015291 secondary active transmembrane transporter activity 26/2194 287/18639 0.0905923344947735 0.769621933750266 0.941158765686913 0.999999999998594 GO:0004518 nuclease activity 18/2194 209/18639 0.0861244019138756 0.731664871136157 0.942548799171225 0.999999999998594 GO:0043177 organic acid binding 16/2194 189/18639 0.0846560846560847 0.719190866866345 0.942596226855127 0.999999999998594 GO:0001217 DNA-binding transcription repressor activity 25/2194 278/18639 0.0899280575539568 0.763978607451322 0.942878893299181 0.999999999998594 GO:0003887 DNA-directed DNA polymerase activity 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0005212 structural constituent of eye lens 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0005283 amino acid:sodium symporter activity 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0140102 catalytic activity, acting on a rRNA 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0140103 catalytic activity, acting on a glycoprotein 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/2194 23/18639 0.0434782608695652 0.369367048472118 0.943989164976353 0.999999999998594 GO:0016830 carbon-carbon lyase activity 3/2194 51/18639 0.0588235294117647 0.499731889109336 0.948881644180512 0.999999999998594 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2194 24/18639 0.0416666666666667 0.353976754785779 0.950590355997082 0.999999999998594 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/2194 24/18639 0.0416666666666667 0.353976754785779 0.950590355997082 0.999999999998594 GO:0140612 DNA damage sensor activity 1/2194 24/18639 0.0416666666666667 0.353976754785779 0.950590355997082 0.999999999998594 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/2194 52/18639 0.0576923076923077 0.490121660472618 0.953370623702839 0.999999999998594 GO:0098631 cell adhesion mediator activity 5/2194 76/18639 0.0657894736842105 0.558910665451231 0.953604595919715 0.999999999998594 GO:0008236 serine-type peptidase activity 16/2194 194/18639 0.0824742268041237 0.700655019782161 0.955506615921506 0.999999999998594 GO:0061775 cohesin loader activity 12/2194 153/18639 0.0784313725490196 0.666309185479114 0.956057279354467 0.999999999998594 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2194 25/18639 0.04 0.339817684594348 0.956413872459204 0.999999999998594 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2194 25/18639 0.04 0.339817684594348 0.956413872459204 0.999999999998594 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2194 25/18639 0.04 0.339817684594348 0.956413872459204 0.999999999998594 GO:0019707 protein-cysteine S-acyltransferase activity 1/2194 25/18639 0.04 0.339817684594348 0.956413872459204 0.999999999998594 GO:0017046 peptide hormone binding 3/2194 53/18639 0.0566037735849057 0.480874081973134 0.957488843995409 0.999999999998594 GO:0015144 carbohydrate transmembrane transporter activity 2/2194 40/18639 0.05 0.424772105742935 0.957855035387194 0.999999999998594 GO:0071949 FAD binding 2/2194 40/18639 0.05 0.424772105742935 0.957855035387194 0.999999999998594 GO:0008528 G protein-coupled peptide receptor activity 9/2194 122/18639 0.0737704918032787 0.626712942899413 0.958294761109362 0.999999999998594 GO:0016757 glycosyltransferase activity 23/2194 267/18639 0.0861423220973783 0.731817111017791 0.960933344405267 0.999999999998594 GO:0015145 monosaccharide transmembrane transporter activity 1/2194 26/18639 0.0384615384615385 0.326747773648412 0.961551293960467 0.999999999998594 GO:0030247 polysaccharide binding 1/2194 26/18639 0.0384615384615385 0.326747773648412 0.961551293960467 0.999999999998594 GO:0008194 UDP-glycosyltransferase activity 11/2194 145/18639 0.0758620689655172 0.644481815609971 0.962205674619454 0.999999999998594 GO:0015293 symporter activity 11/2194 146/18639 0.0753424657534247 0.640067556598944 0.964441402963483 0.999999999998594 GO:0005385 zinc ion transmembrane transporter activity 1/2194 27/18639 0.037037037037037 0.314646004254026 0.966083419950406 0.999999999998594 GO:0016405 CoA-ligase activity 1/2194 27/18639 0.037037037037037 0.314646004254026 0.966083419950406 0.999999999998594 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/2194 27/18639 0.037037037037037 0.314646004254026 0.966083419950406 0.999999999998594 GO:0035255 ionotropic glutamate receptor binding 1/2194 27/18639 0.037037037037037 0.314646004254026 0.966083419950406 0.999999999998594 GO:0003777 microtubule motor activity 4/2194 68/18639 0.0588235294117647 0.499731889109336 0.966262184108199 0.999999999998594 GO:0008094 ATP-dependent activity, acting on DNA 17/2194 210/18639 0.080952380952381 0.687726266440943 0.967096075764641 0.999999999998594 GO:0005245 voltage-gated calcium channel activity 2/2194 43/18639 0.0465116279069767 0.395136842551568 0.969247968757622 0.999999999998594 GO:0004519 endonuclease activity 9/2194 127/18639 0.0708661417322835 0.602039204989987 0.969976591356754 0.999999999998594 GO:0045499 chemorepellent activity 1/2194 28/18639 0.0357142857142857 0.303408646959239 0.970081538187501 0.999999999998594 GO:0051119 sugar transmembrane transporter activity 1/2194 28/18639 0.0357142857142857 0.303408646959239 0.970081538187501 0.999999999998594 GO:0051393 alpha-actinin binding 1/2194 28/18639 0.0357142857142857 0.303408646959239 0.970081538187501 0.999999999998594 GO:0015294 solute:monoatomic cation symporter activity 8/2194 116/18639 0.0689655172413793 0.585892559645428 0.97014018872217 0.999999999998594 GO:0001653 peptide receptor activity 9/2194 128/18639 0.0703125 0.597335773701003 0.971922413904906 0.999999999998594 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/2194 44/18639 0.0454545454545455 0.386156459766305 0.972337366698261 0.999999999998594 GO:0005416 amino acid:monoatomic cation symporter activity 1/2194 29/18639 0.0344827586206897 0.292946279822714 0.97360854400216 0.999999999998594 GO:0099604 ligand-gated calcium channel activity 1/2194 29/18639 0.0344827586206897 0.292946279822714 0.97360854400216 0.999999999998594 GO:0000510 H3-H4 histone complex chaperone activity 11/2194 151/18639 0.0728476821192053 0.618873266645336 0.973939898301419 0.999999999998594 GO:0140584 chromatin extrusion motor activity 11/2194 151/18639 0.0728476821192053 0.618873266645336 0.973939898301419 0.999999999998594 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 11/2194 151/18639 0.0728476821192053 0.618873266645336 0.973939898301419 0.999999999998594 GO:0140849 ATP-dependent H2AZ histone chaperone activity 11/2194 151/18639 0.0728476821192053 0.618873266645336 0.973939898301419 0.999999999998594 GO:0008009 chemokine activity 2/2194 45/18639 0.0444444444444444 0.377575205104831 0.975125959974139 0.999999999998594 GO:0016798 hydrolase activity, acting on glycosyl bonds 9/2194 130/18639 0.0692307692307692 0.588145992567141 0.975474171547776 0.999999999998594 GO:0015616 DNA translocase activity 11/2194 152/18639 0.0723684210526316 0.614801731996354 0.975538489040415 0.999999999998594 GO:0140674 ATP-dependent histone chaperone activity 11/2194 152/18639 0.0723684210526316 0.614801731996354 0.975538489040415 0.999999999998594 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2194 30/18639 0.0333333333333333 0.283181403828624 0.976719927906473 0.999999999998594 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/2194 30/18639 0.0333333333333333 0.283181403828624 0.976719927906473 0.999999999998594 GO:0033612 receptor serine/threonine kinase binding 1/2194 30/18639 0.0333333333333333 0.283181403828624 0.976719927906473 0.999999999998594 GO:0140713 histone chaperone activity 12/2194 164/18639 0.0731707317073171 0.621617715721369 0.977281086200348 0.999999999998594 GO:0004252 serine-type endopeptidase activity 13/2194 176/18639 0.0738636363636364 0.627504247120245 0.978947673140862 0.999999999998594 GO:0046943 carboxylic acid transmembrane transporter activity 14/2194 188/18639 0.074468085106383 0.632639306425648 0.980526630900288 0.999999999998594 GO:0005342 organic acid transmembrane transporter activity 14/2194 189/18639 0.0740740740740741 0.629292008508052 0.981655446107255 0.999999999998594 GO:0015106 bicarbonate transmembrane transporter activity 1/2194 32/18639 0.03125 0.265482566089335 0.981885894043072 0.999999999998594 GO:0042910 xenobiotic transmembrane transporter activity 1/2194 32/18639 0.03125 0.265482566089335 0.981885894043072 0.999999999998594 GO:0038187 pattern recognition receptor activity 2/2194 48/18639 0.0416666666666667 0.353976754785779 0.981954727266592 0.999999999998594 GO:0140658 ATP-dependent chromatin remodeler activity 11/2194 158/18639 0.069620253164557 0.591454830781302 0.983397362955764 0.999999999998594 GO:0015171 amino acid transmembrane transporter activity 6/2194 102/18639 0.0588235294117647 0.499731889109336 0.984954329682668 0.999999999998594 GO:0004536 DNA nuclease activity 3/2194 64/18639 0.046875 0.398223849134002 0.985110610709159 0.999999999998594 GO:0003689 DNA clamp loader activity 11/2194 160/18639 0.06875 0.584061645396536 0.985450821245694 0.999999999998594 GO:0015020 glucuronosyltransferase activity 1/2194 34/18639 0.0294117647058824 0.249865944554668 0.985905911074216 0.999999999998594 GO:0005253 monoatomic anion channel activity 6/2194 103/18639 0.058252427184466 0.494880123195653 0.986119065783805 0.999999999998594 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/2194 91/18639 0.0549450549450549 0.466782533783445 0.986442937863905 0.999999999998594 GO:0008514 organic anion transmembrane transporter activity 21/2194 269/18639 0.0780669144981413 0.663212953204583 0.987096387026854 0.999999999998594 GO:0042805 actinin binding 1/2194 37/18639 0.027027027027027 0.22960654364483 0.990327388212659 0.999999999998594 GO:0043394 proteoglycan binding 1/2194 37/18639 0.027027027027027 0.22960654364483 0.990327388212659 0.999999999998594 GO:0005109 frizzled binding 1/2194 38/18639 0.0263157894736842 0.223564266180492 0.991468217707414 0.999999999998594 GO:0004222 metalloendopeptidase activity 6/2194 110/18639 0.0545454545454545 0.463387751719566 0.992187570679949 0.999999999998594 GO:0050660 flavin adenine dinucleotide binding 4/2194 86/18639 0.0465116279069767 0.395136842551568 0.993352888762392 0.999999999998594 GO:0008509 monoatomic anion transmembrane transporter activity 9/2194 149/18639 0.0604026845637584 0.513147510293479 0.993704430799404 0.999999999998594 GO:0140097 catalytic activity, acting on DNA 26/2194 336/18639 0.0773809523809524 0.657385401745019 0.99416199872902 0.999999999998594 GO:0042056 chemoattractant activity 1/2194 42/18639 0.0238095238095238 0.20227243130616 0.99483592464658 0.999999999998594 GO:0015103 inorganic anion transmembrane transporter activity 10/2194 165/18639 0.0606060606060606 0.514875279688406 0.995400825289824 0.999999999998594 GO:0008375 acetylglucosaminyltransferase activity 1/2194 43/18639 0.0232558139534884 0.197568421275784 0.995445161691555 0.999999999998594 GO:0019199 transmembrane receptor protein kinase activity 3/2194 78/18639 0.0384615384615385 0.326747773648412 0.99633746594954 0.999999999998594 GO:0004497 monooxygenase activity 5/2194 106/18639 0.0471698113207547 0.400728401644279 0.996384508364446 0.999999999998594 GO:0046915 transition metal ion transmembrane transporter activity 1/2194 45/18639 0.0222222222222222 0.188787602552416 0.996456565734128 0.999999999998594 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/2194 181/18639 0.0607734806629834 0.516297587090861 0.996635538172244 0.999999999998594 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2194 46/18639 0.0217391304347826 0.184683524236059 0.996874673445181 0.999999999998594 GO:0003730 mRNA 3'-UTR binding 18/2194 262/18639 0.0687022900763359 0.583656328501743 0.996996145878235 0.999999999998594 GO:0004867 serine-type endopeptidase inhibitor activity 4/2194 95/18639 0.0421052631578947 0.357702825888788 0.997177999189657 0.999999999998594 GO:0099095 ligand-gated monoatomic anion channel activity 1/2194 47/18639 0.0212765957446809 0.180754087550185 0.99724346634903 0.999999999998594 GO:0008201 heparin binding 10/2194 172/18639 0.0581395348837209 0.49392105318946 0.997275383074782 0.999999999998594 GO:0005539 glycosaminoglycan binding 16/2194 242/18639 0.0661157024793388 0.561682123296443 0.997400645333121 0.999999999998594 GO:0005261 monoatomic cation channel activity 25/2194 341/18639 0.0733137829912024 0.622832999623072 0.997507664994401 0.999999999998594 GO:0008083 growth factor activity 9/2194 162/18639 0.0555555555555556 0.471969006381039 0.997681611585213 0.999999999998594 GO:0016500 protein-hormone receptor activity 2/2194 67/18639 0.0298507462686567 0.253595287010708 0.997771729077746 0.999999999998594 GO:0005254 chloride channel activity 3/2194 83/18639 0.036144578313253 0.307064172826218 0.997811772162311 0.999999999998594 GO:0005004 GPI-linked ephrin receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005008 hepatocyte growth factor receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005009 insulin receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005011 macrophage colony-stimulating factor receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005020 stem cell factor receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0008288 boss receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0036332 placental growth factor receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0038062 protein tyrosine kinase collagen receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0060175 brain-derived neurotrophic factor receptor activity 1/2194 49/18639 0.0204081632653061 0.173376369690994 0.997855679409978 0.999999999998594 GO:0005006 epidermal growth factor receptor activity 1/2194 50/18639 0.02 0.169908842297174 0.998108753071866 0.999999999998594 GO:0005007 fibroblast growth factor receptor activity 1/2194 50/18639 0.02 0.169908842297174 0.998108753071866 0.999999999998594 GO:0005017 platelet-derived growth factor receptor activity 1/2194 50/18639 0.02 0.169908842297174 0.998108753071866 0.999999999998594 GO:0005019 platelet-derived growth factor beta-receptor activity 1/2194 50/18639 0.02 0.169908842297174 0.998108753071866 0.999999999998594 GO:0005010 insulin-like growth factor receptor activity 1/2194 51/18639 0.0196078431372549 0.166577296369779 0.998331970875961 0.999999999998594 GO:0005021 vascular endothelial growth factor receptor activity 1/2194 51/18639 0.0196078431372549 0.166577296369779 0.998331970875961 0.999999999998594 GO:0005030 neurotrophin receptor activity 1/2194 51/18639 0.0196078431372549 0.166577296369779 0.998331970875961 0.999999999998594 GO:0005201 extracellular matrix structural constituent 9/2194 168/18639 0.0535714285714286 0.455112970438859 0.998561562687529 0.999999999998594 GO:0005003 ephrin receptor activity 1/2194 53/18639 0.0188679245283019 0.160291360657711 0.998702506962357 0.999999999998594 GO:0005005 transmembrane-ephrin receptor activity 1/2194 53/18639 0.0188679245283019 0.160291360657711 0.998702506962357 0.999999999998594 GO:0038064 collagen receptor activity 1/2194 53/18639 0.0188679245283019 0.160291360657711 0.998702506962357 0.999999999998594 GO:0015108 chloride transmembrane transporter activity 5/2194 121/18639 0.0413223140495868 0.351051327060277 0.99910111241286 0.999999999998594 GO:0005216 monoatomic ion channel activity 33/2194 448/18639 0.0736607142857143 0.625780334353431 0.999264244063681 0.999999999998594 GO:0015081 sodium ion transmembrane transporter activity 8/2194 164/18639 0.0487804878048781 0.414411810480912 0.999297812210991 0.999999999998594 GO:0004714 transmembrane receptor protein tyrosine kinase activity 1/2194 60/18639 0.0166666666666667 0.141590701914312 0.999461530102708 0.999999999998594 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 33/2194 484/18639 0.0681818181818182 0.579234689649457 0.999908832548233 0.999999999998594 GO:0005179 hormone activity 4/2194 132/18639 0.0303030303030303 0.257437639844203 0.99993253448954 0.999999999998594 GO:0005249 voltage-gated potassium channel activity 2/2194 98/18639 0.0204081632653061 0.173376369690994 0.999936041583955 0.999999999998594 GO:0001216 DNA-binding transcription activator activity 33/2194 491/18639 0.0672097759674134 0.570976761283783 0.999940569510682 0.999999999998594 GO:0005244 voltage-gated monoatomic ion channel activity 6/2194 173/18639 0.0346820809248555 0.294639610919955 0.999976111477746 0.999999999998594 GO:0022843 voltage-gated monoatomic cation channel activity 4/2194 143/18639 0.027972027972028 0.237634744471572 0.999978821343361 0.999999999998594 GO:0022832 voltage-gated channel activity 6/2194 175/18639 0.0342857142857143 0.29127230108087 0.99998038585227 0.999999999998594 GO:0005125 cytokine activity 10/2194 234/18639 0.0427350427350427 0.363053081831569 0.999984080224207 0.999999999998594 GO:0046873 metal ion transmembrane transporter activity 27/2194 450/18639 0.06 0.509726526891522 0.999989802534661 0.999999999998594 GO:0015079 potassium ion transmembrane transporter activity 4/2194 160/18639 0.025 0.212386052871468 0.999996578851796 0.999999999998594 GO:0005267 potassium channel activity 2/2194 124/18639 0.0161290322580645 0.137023259917076 0.999996985830241 0.999999999998594 GO:0003823 antigen binding 3/2194 174/18639 0.0172413793103448 0.146473139911357 0.99999990808266 0.999999999998594 GO:0099094 ligand-gated monoatomic cation channel activity 1/2194 136/18639 0.00735294117647059 0.062466486138667 0.999999962464057 0.999999999998594 GO:0015276 ligand-gated monoatomic ion channel activity 3/2194 186/18639 0.0161290322580645 0.137023259917076 0.999999977077374 0.999999999998594 GO:0022834 ligand-gated channel activity 3/2194 188/18639 0.0159574468085106 0.135565565662639 0.999999981829735 0.999999999998594 GO:0022836 gated channel activity 10/2194 318/18639 0.0314465408805031 0.267152267762852 0.999999994319657 0.999999999998594 GO:0045182 translation regulator activity 11/2194 356/18639 0.0308988764044944 0.262499615908555 0.999999999404179 0.999999999998594 GO:0030371 translation repressor activity 6/2194 329/18639 0.0182370820668693 0.154932075043016 0.999999999998594 0.999999999998594