category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	106/1820	238/9376	2.29443161880137	RPS21/RPS15A/RPL39/RPL35A/RPL8/RPL36/RPS7/RPL37/RPL34/FAU/RPS4X/RPL30/RPS13/RPS11/RPL37A/RPL12/RPLP2/RPL28/RPS29/RPS28/RPS8/RPL11/RPS24/RPS27/RPLP1/RPL41/RPL10/RPL18/RPL21/RPL32/RPL18A/RPS3/RPL13/RPS14/RPS27A/RPL29/RPS15/RPL5/RPL6/UBA52/RPL14/RPS23/RPS3A/RPL9/RPL7/RPS19/RPS16/IL1B/RPS2/RPL24/RPL22/RPL15/RPL19/RPS5/RPL26/RPL23/RPS12/RPL38/RPL27/RPS6/RPS20/RPL27A/RPL10A/RPSA/RSL24D1/RPL23A/TLR2/RPL13A/RPL3/TRAF3/CASP1/MYD88/RPL31/MAPK8/RPL35/RPL4/C7/RPL36AL/NFKB1/C5AR1/RPS26/RPLP0/PRKCB/C3/TAB2/NLRP3/MAPK1/CXCL8/ADAM17/RPS10-NUDT3/STAT1/PIK3CB/TBK1/MAPK10/RPS10/VWF/RPL36A-HNRNPH2/RPS27L/IRAK4/MAPK14/IL6R/C1S/ACE/C5/IKBKE/IL6	9.92698514638846
Genetic Information Processing	Translation	hsa03010	Ribosome	97/1820	222/9376	2.25094545094545	RPS21/RPS15A/RPL39/RPL35A/RPL8/RPL36/RPS7/RPL37/RPL34/FAU/RPS4X/RPL30/RPS13/RPS11/RPL37A/RPL12/RPLP2/RPL28/RPS29/RPS28/RPS8/RPL11/RPS24/RPS27/RPLP1/RPL41/RPL10/RPL18/RPL21/RPL32/RPL18A/RPS3/RPL13/RPS14/RPS27A/RPL29/RPS15/RPL5/RPL6/UBA52/RPL14/RPS23/RPS3A/RPL9/RPL7/RPS19/RPS16/RPS2/RPL24/RPL22/RPL15/RPL19/RPS5/RPL26/RPL23/RPS12/RPL38/RPL27/RPS6/RACK1/RPS20/RPL27A/RPL10A/RPSA/RSL24D1/RPL23A/MRPL33/RPL13A/RPL3/RPL31/RPL35/RPL4/RPL36AL/MRPL52/RPS26/RPLP0/MRPL11/MRPL51/MRPL13/MRPL54/MRPL43/MRPL15/MRPL36/MRPL47/RPS10-NUDT3/MRPL20/MRPL44/MRPS10/MRPL42/MRPL55/MRPS9/RPS10/RPL36A-HNRNPH2/MRPS27/RPS27L/MRPL48/MRPL53	9.25730905530846
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	74/1820	205/9376	1.85961940498526	NDUFB1/COX7C/PLCB1/ATP5F1E/COX6B1/RAC2/PPIF/NDUFB5/CYBA/COX7A2L/ATP5MC2/COX7B/COX4I1/COX7A2/SMAD3/UQCRH/NDUFA2/UQCRB/PPP1CA/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/ATP5F1D/NFKB1/COX5A/SLC25A5/CAMK2D/NDUFA4/NDUFA12/PRKCB/SDHB/NDUFB6/COL3A1/COX5B/NCF2/ATP5MC3/NDUFA1/NDUFB3/MPC1/NDUFAB1/SLC25A6/ATP5PF/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/ATP5PO/ATP5F1C/GAPDH/NDUFB10/COX6A1/G6PD/RAC1/PIK3CB/COL1A1/COX6C/VDAC1/NDUFB2/ATP2A3/MAPK10/MPC2/COX8A/SMAD2/NDUFA5/TGFB1/TGFBR1/PPP1CB/PTEN/UQCRHL/MAPK14/ACE	6.10731263241768
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	85/1820	248/9376	1.76568592697625	RPS3/S100A10/IL1B/PAK1/ACTB/RIPK2/MAP2K1/RAB7A/TLR2/ACTR3/ARPC3/CTNNB1/FLNA/TUBA4A/CASP1/MYD88/ARL8B/MAPK8/RHOH/TXN/MYL12A/ARPC2/MYL12B/ANXA2/PFN1/DYNLT1/NFKB1/DCTN3/PYCARD/BRK1/CYFIP2/MAP2K3/ELMO1/TAB2/DYNC1LI1/EXOC4/RHOA/PTPRC/RAB9A/RALA/NLRP3/MAPK1/RRAS/KPNA3/CXCL8/RHOG/CASP4/CASP8/ARPC4/GAPDH/ACTR10/ACTG1/DCTN2/RAC1/TCF7L2/PIK3CB/MAP2K4/SNX9/STX10/BCL2/ARPC1A/MAPK10/ABI1/RAF1/KPNA4/BIRC3/ACBD3/EXOC2/RAB7B/DYNLL1/MYL9/TUBB6/IRAK4/MAP2K6/MAPK14/PIK3CG/AHNAK2/ARF6/CASP5/CYTH1/TNFSF10/TIRAP/LEF1/DYNC2LI1/IL6	5.99741425075739
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	99/1820	308/9376	1.65588697017268	GPX1/NDUFB1/COX7C/PLCB1/ATP5F1E/COX6B1/PPIF/RCOR1/NDUFB5/ERN1/COX7A2L/ITPR1/ATP5MC2/COX7B/COX4I1/COX7A2/CREB5/UQCRH/TUBA4A/PSMA4/POLR2L/DNAI2/NDUFA2/UQCRB/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/ATP5F1D/TAF4B/COX5A/PSMA5/DCTN3/SLC25A5/NDUFA4/NDUFA12/SDHB/NDUFB6/COX5B/SOD2/ATP5MC3/NDUFA1/NDUFB3/PSMA7/MAP3K5/PSMB1/DNAH17/GNAQ/AMBRA1/NDUFAB1/SLC25A6/ATP5PF/PSMB7/WIPI1/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/ATP5PO/ATP5F1C/IFT57/TBPL1/POLR2G/PSMD8/POLR2I/CASP8/CASP9/NRF1/PSMB6/NDUFB10/COX6A1/ACTR10/DCTN2/PSMB2/PSMD4/PPARG/COX6C/CREB1/HDAC1/VDAC1/SEM1/TGM2/PSMD12/NDUFB2/PSMD9/MAPK10/COX8A/NRBF2/SLC1A2/NDUFA5/ATG2A/TUBB6/UQCRHL/RB1CC1/GPX7/DNAH14/TBP	5.74412607426537
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	54/1820	138/9376	2.01586239847109	IL1B/ACTB/RAC2/MAP2K1/ITGA4/ACTR3/ARPC3/SRC/CASP1/LCP2/MYD88/MAPK8/ARPC2/NFKB1/PTK2B/PYCARD/RPS6KA3/MAP2K3/ELMO1/TAB2/GNAQ/MEFV/RHOA/WAS/NLRP3/MAPK1/CXCL8/RHOG/ARPC4/ACTG1/RAC1/PIK3CB/TBK1/MAP2K4/ARPC1A/WIPF3/SKAP2/MAPK10/FYB1/NFATC3/TICAM1/IRAK4/MAP2K6/ITGA5/MAPK14/LCK/PIP5K1B/ARF6/WASF2/CD8A/LAT/CD8B/IL10/IL6	5.90011949228271
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	90/1820	275/9376	1.68599400599401	FYN/IL1B/NDUFB1/COX7C/EIF2AK3/ATP5F1E/COX6B1/RAC2/PPIF/NDUFB5/CYBA/COX7A2L/ITPR1/ATP5MC2/COX7B/COX4I1/COX7A2/CREB5/UQCRH/TUBA4A/PSMA4/NDUFA2/UQCRB/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/C7/ATP5F1D/COX5A/PSMA5/SLC25A5/NDUFA4/NDUFA12/SDHB/NDUFB6/COX5B/NCF2/ATP5MC3/NDUFA1/NDUFB3/PSMA7/PSMB1/NDUFAB1/SLC25A6/ATP5PF/PSMB7/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/MCU/ATP5PO/ATP5F1C/MAPK1/PPP3CC/PSMD8/CASP9/PSMB6/NDUFB10/COX6A1/PSMB2/PSMD4/RAC1/PIK3CB/COX6C/CREB1/VDAC1/SEM1/PSMD12/NDUFB2/NCAM1/PPP3CB/PSMD9/MAPK10/COX8A/IL1A/NDUFA5/CACNA1D/TUBB6/UQCRHL/MAPK14/HSPA6/CAV1/PRNP/C5/CAV2/IL6	5.66653360009458
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	140/1820	480/9376	1.5025641025641	GPX1/RPS27A/UBA52/IL1B/NDUFB1/COX7C/EIF2AK3/PLCB1/C9orf72/ATP5F1E/LRRK2/COX6B1/BID/DKK1/PPIF/NDUFB5/MAP2K1/ERN1/COX7A2L/ITPR1/ATP5MC2/MAP1LC3B/COX7B/COX4I1/COX7A2/CTNNB1/UQCRH/CAPN2/TUBA4A/PSMA4/SNCA/DNAI2/NDUFA2/UBE2L6/UQCRB/PARK7/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/ATP5F1D/NFKB1/COX5A/PSMA5/DCTN3/SLC25A5/CAMK2D/NDUFA4/NDUFA12/PRKCB/SDHB/NDUFB6/KRAS/ATXN1/UBE2J1/COX5B/TANK/RAB1A/MAP2K3/ATP5MC3/NDUFA1/NDUFB3/PSMA7/BRAF/MAP3K5/PSMB1/DNAH17/GNAQ/AMBRA1/WNT2B/NDUFAB1/SLC25A6/HSD17B10/ATP5PF/PSMB7/WIPI1/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/RAB8A/MCU/ATP5PO/ATP5F1C/PTGS2/ATXN3/MAPK1/IFT57/DERL1/PPP3CC/PSEN1/PSMD8/CASP8/CASP9/PSMB6/NDUFB10/COX6A1/ACTR10/DCTN2/TNFRSF1B/PSMB2/PSMD4/RAC1/TBK1/COX6C/VDAC1/SEM1/PSMD12/NDUFB2/CHMP2B/BCL2/PPP3CB/FAS/ATP2A3/PSMD9/MAPK10/COX8A/NRBF2/RAF1/IL1A/NDUFA5/ATG2A/CACNA1D/TUBB6/FZD1/ARAF/MAP2K6/UQCRHL/MAPK14/CSF1/RB1CC1/GPX7/CDK5/PRNP/MAP1LC3B2/DNAH14/IL6/FZD2	5.54740729723449
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	77/1820	227/9376	1.74747543205693	NDUFB1/COX7C/ATP5F1E/COX6B1/PPIF/NDUFB5/CYBA/MAP2K1/COX7A2L/ATP5MC2/COX7B/COX4I1/COX7A2/UQCRH/SRC/HIF1A/MGST1/NDUFA2/UQCRB/GSTO1/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/ATP5F1D/NFKB1/COX5A/SLC25A5/NDUFA4/NDUFA12/SDHB/NDUFB6/KRAS/COX5B/NCF2/SOD2/ATP5MC3/NDUFA1/NDUFB3/BRAF/AHR/MAP3K5/NDUFAB1/SLC25A6/ATP5PF/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/ATP5PO/ATP5F1C/MAPK1/PTPRJ/PTPN1/NDUFB10/COX6A1/RAC1/PIK3CB/COX6C/HGF/MAP2K4/VDAC1/NDUFB2/MAPK10/COX8A/RAF1/NDUFA5/SOS2/PTEN/ARAF/UQCRHL/MAPK14/MGST3/NQO1/MET	5.59497815554109
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	111/1820	368/9376	1.5538939321548	GPX1/NDUFB1/COX7C/NRG1/EIF2AK3/ACTB/C9orf72/ATP5F1E/COX6B1/BID/NDUFB5/ERN1/COX7A2L/ATP5MC2/MAP1LC3B/COX7B/COX4I1/COX7A2/UQCRH/TUBA4A/NUP214/PSMA4/CASP1/DNAI2/NDUFA2/UQCRB/NDUFB9/ATP5PB/UQCRFS1/ALYREF/ATP5F1D/PFN1/COX5A/PSMA5/DCTN3/NDUFA4/NDUFA12/SDHB/NDUFB6/COX5B/TANK/NXT1/RAB1A/MAP2K3/ATP5MC3/NDUFA1/NDUFB3/PSMA7/MAP3K5/PSMB1/DNAH17/AMBRA1/NDUFAB1/NUP98/ATP5PF/PSMB7/WIPI1/NDUFB11/NDUFS7/SEC13/NDUFS5/NDUFB4/RAB8A/MCU/ATP5PO/ATP5F1C/DERL1/PPP3CC/ANG/PSMD8/CASP9/PSMB6/NDUFB10/COX6A1/ACTR10/ACTG1/DCTN2/TNFRSF1B/PSMB2/PSMD4/RAC1/TBK1/COX6C/VDAC1/SEM1/PSMD12/NDUFB2/CHMP2B/NUP37/BCL2/PPP3CB/PSMD9/COX8A/NUP54/NRBF2/SLC1A2/HNRNPA1/MATR3/NDUFA5/RAE1/ATG2A/TUBB6/MAP2K6/UQCRHL/MAPK14/RB1CC1/NUP88/GPX7/MAP1LC3B2/NUP210L/DNAH14	5.32000065391081
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	114/1820	388/9376	1.51362863940184	IL1B/NDUFB1/COX7C/EIF2AK3/PLCB1/ATP5F1E/COX6B1/BID/DKK1/PPIF/NDUFB5/MAP2K1/ERN1/COX7A2L/ITPR1/ATP5MC2/COX7B/COX4I1/COX7A2/CTNNB1/UQCRH/CAPN2/TUBA4A/PSMA4/SNCA/NDUFA2/UQCRB/MAPK8/NDUFB9/ATP5PB/VDAC2/UQCRFS1/ATP5F1D/NFKB1/COX5A/PSMA5/SLC25A5/NDUFA4/NDUFA12/SDHB/NDUFB6/KRAS/COX5B/ATP5MC3/NDUFA1/NDUFB3/PSMA7/BRAF/MAP3K5/PSMB1/GNAQ/AMBRA1/WNT2B/NDUFAB1/SLC25A6/HSD17B10/SLC39A11/ATP5PF/PSMB7/WIPI1/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/MCU/ATP5PO/ATP5F1C/PTGS2/MAPK1/ADAM17/PPP3CC/PSEN1/PSMD8/CASP8/CASP9/GAPDH/PSMB6/NDUFB10/COX6A1/PSMB2/PSMD4/PIK3CB/COX6C/VDAC1/SEM1/PSMD12/NDUFB2/LPL/PPP3CB/FAS/ATP2A3/PSMD9/MAPK10/RTN3/SLC39A9/COX8A/APOE/NRBF2/RAF1/IL1A/NDUFA5/ATG2A/CACNA1D/TUBB6/FZD1/ARAF/UQCRHL/CSF1/RB1CC1/CDK5/SLC39A8/IL6/FZD2	5.07117876302233
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	81/1820	253/9376	1.64934196238544	H3-3B/H3-3A/CD44/RPS27A/UBA52/IL1B/U2AF1/PLCB1/ACTB/DIAPH1/RIPK2/MALT1/ITPR1/MAP1LC3B/ACTR3/ARPC3/CALCOCO2/CAPN2/SRC/CASP1/MYD88/MAPK8/MYL12A/ARPC2/PRKCE/MYL12B/PFN1/NFKB1/UBE2D1/PYCARD/HK2/ATG5/RBX1/C3/VCL/ELMO1/TNIP1/TAB2/SEPTIN6/UBE2D2/RHOA/WIPI1/HCLS1/ACTN1/NLRP3/MAPK1/CUL1/CXCL8/CAST/HK1/CASP4/RPTOR/ARPC4/BCL10/CAPNS1/ACTG1/RAC1/PIK3CB/TBK1/FNBP1/VDAC1/FBXW11/BCL2/ARPC1A/MAPK10/IL1R1/UBE2N/RPS6KA5/SEPTIN7/MYL9/FOXO1/U2AF1L4/ATG12/PRKCQ/ITGA5/MAPK14/ARF6/WASF2/BTRC/CYTH1/MAP1LC3B2	5.13854601450036
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	51/1820	138/9376	1.90387004300048	PPA1/NDUFB1/COX7C/ATP5F1E/COX6B1/NDUFB5/COX7A2L/ATP5MC2/COX7B/COX4I1/COX7A2/UQCRH/NDUFA2/UQCRB/NDUFB9/ATP5PB/UQCRFS1/ATP5F1D/COX5A/NDUFA4/NDUFA12/SDHB/ATP6V1G1/NDUFB6/COX5B/COX17/ATP5MC3/NDUFA1/NDUFB3/ATP5MG/NDUFAB1/ATP5ME/ATP5PF/NDUFB11/NDUFS7/NDUFS5/NDUFB4/ATP5PO/ATP5F1C/NDUFB10/COX6A1/COX6C/NDUFB2/ATP6V0E1/COX8A/NDUFA5/ATP6V0D1/ATP6V0B/UQCRHL/ATP6V1B2/ATP6V1H	5.24966891896361
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	76/1820	235/9376	1.66606499883096	NDUFB1/COX7C/ACTB/RPS6/ATP5F1E/COX6B1/NDUFB5/ACSL5/COX7A2L/ATP5MC2/COX7B/COX4I1/COX7A2/CREB5/UQCRH/NDUFA2/UQCRB/ADCY3/NDUFB9/ATP5PB/UQCRFS1/ATP5F1D/SMARCD3/COX5A/NDUFA4/NDUFA12/SDHB/RPS6KA3/PRKAG2/NDUFB6/KRAS/COX5B/COX17/RHEB/MAP2K3/ATP5MC3/NDUFA1/COX14/NDUFB3/MAP3K5/ATP5MG/ACSL1/NDUFAF2/NDUFAB1/ATP5ME/ATP5PF/NDUFB11/NDUFS7/NDUFS5/NDUFB4/COA3/ATP5PO/ATP5F1C/RPTOR/NDUFB10/COX6A1/ACTG1/PPARG/COX6C/CREB1/NDUFB2/COA1/ACSL3/ZNF516/COA5/COX8A/NDUFAF8/NDUFA5/ADCY9/SOS2/NDUFAF4/ACSL4/PRKG1/UQCRHL/MAPK14/PNPLA2	5.07491820231523
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	84/1820	268/9376	1.61469575200918	RPS27A/UBA52/NDUFB1/COX7C/EIF2AK3/ATP5F1E/LRRK2/COX6B1/PPIF/NDUFB5/ERN1/COX7A2L/ITPR1/ATP5MC2/COX7B/COX4I1/COX7A2/UQCRH/TUBA4A/PSMA4/SNCA/GNAL/NDUFA2/UBE2L6/UQCRB/PARK7/MAPK8/NDUFB9/ATP5PB/TXN/VDAC2/UQCRFS1/ATP5F1D/COX5A/PSMA5/SLC25A5/CAMK2D/NDUFA4/NDUFA12/SDHB/NDUFB6/UBE2J1/COX5B/ATP5MC3/NDUFA1/NDUFB3/PSMA7/MAP3K5/PSMB1/NDUFAB1/SLC25A6/SLC39A11/ATP5PF/PSMB7/NDUFB11/NDUFS7/NDUFS5/NDUFB4/VDAC3/MCU/ATP5PO/ATP5F1C/PSMD8/CASP9/PSMB6/NDUFB10/COX6A1/PSMB2/PSMD4/SLC18A2/COX6C/VDAC1/SEM1/PSMD12/NDUFB2/PSMD9/MAPK10/SLC39A9/COX8A/NDUFA5/TUBB6/UQCRHL/SLC39A8/ADORA2A	5.01061986023534
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	55/1820	157/9376	1.80471757541821	IL1B/NDUFB1/COX7C/EIF2AK3/COX6B1/BID/NDUFB5/ERN1/COX7A2L/COX7B/COX4I1/COX7A2/UQCRH/NDUFA2/UQCRB/MAPK8/NDUFB9/UQCRFS1/RXRA/NFKB1/COX5A/NDUFA4/NDUFA12/SDHB/PRKAG2/NDUFB6/COX5B/NDUFA1/NDUFB3/MAP3K5/NDUFAB1/NDUFB11/NDUFS7/NDUFS5/NDUFB4/CXCL8/CASP8/NDUFB10/COX6A1/RAC1/PIK3CB/PPARG/COX6C/NDUFB2/FAS/MAPK10/COX8A/IL1A/NDUFA5/TGFB1/UQCRHL/MAPK14/LEPR/IL6R/IL6	4.99030124313731
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	41/1820	109/9376	1.93777598548241	IL1B/HLA-DQA2/RARA/SMAD3/HIF1A/IFNGR1/IL2RG/MAPK8/RXRA/NFKB1/HLA-DRB5/AHR/MAPK1/PPP3CC/STAT1/CD3D/CD247/PPP3CB/RORA/CD3E/MAPK10/IL21R/IL1R1/SMAD2/IL12RB1/CD3G/TGFB1/TGFBR1/IL1RAP/NFATC3/PRKCQ/MAPK14/IL6R/LCK/STAT5B/LAT/HLA-DRA/HLA-DPA1/IFNG/IL6/IL27	4.83301487917065
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	65/1820	203/9376	1.64954257565095	FYN/PAK1/ACTB/THBS1/DIAPH1/RAC2/MAP2K1/RAP1B/ITGA4/CTNNB1/FLNA/CAPN2/SRC/PPP1CA/MAPK8/MYL12A/RAP1A/MYL12B/CCND3/PRKCB/RAPGEF1/VCL/BRAF/LAMB3/RHOA/ACTN1/COL6A2/MAPK1/PARVG/COL6A1/ITGB8/CCND2/ACTG1/RAC1/PIK3CB/PARVB/IGF1R/COL1A1/HGF/BCL2/LAMA2/MAPK10/ITGAV/RAF1/BIRC3/COL6A3/VWF/SOS2/PPP1CB/MYL9/PTEN/ITGB7/EMP1/COL9A2/ITGA5/PPP1R12B/PDGFRA/ELK1/PIP5K1B/CAV1/FLNB/ITGB4/MET/CAV2/LAMA4	4.59171900252894
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	56/1820	169/9376	1.70705507510241	RPS27A/UBA52/EIF2AK3/C9orf72/ATG3/MAP2K1/RAB7A/ERN1/ITPR1/IGBP1/MAP1LC3B/CALCOCO2/HIF1A/MAPK8/UVRAG/GABARAPL2/KRAS/ATG5/TANK/RHEB/RAB1A/MTMR3/ATG16L2/AMBRA1/GABARAPL1/WIPI1/CAMKK2/RAB8A/MAPK1/RRAS/RPTOR/PIK3CB/TBK1/IGF1R/BIRC6/BCL2/MAPK10/DAPK1/ATG7/NRBF2/MTMR14/RAF1/TAX1BP1/ATG2A/RAB7B/ATG10/PTEN/ATG12/SUPT20H/PRKCQ/RB1CC1/MAP1LC3B2/EPG5/VMP1/ATG4A/ATG4D	4.55211140582112
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	49/1820	142/9376	1.77768147345612	UBE2R2/RPS27A/UBA52/UBE2E2/ELOB/COP1/CDC26/RNF7/UBE2L6/UBE2E1/UBE2D1/UBE2B/UBE2J1/RBX1/CUL3/PIAS1/UBE2D2/UBE2M/FBXW7/UBE2Q1/ERCC8/UBE2Q2/CUL1/CBL/ANAPC16/WWP2/ELOC/UBE2K/ANAPC15/SMURF2/CUL2/UBA3/UBR5/BIRC6/FBXW11/CUL4A/UBE2Z/UBE2N/BIRC3/UBE2E3/CDC27/VHL/FANCL/HERC1/UBE2S/NEDD4L/UBE4B/BTRC/KLHL13	4.58275191561056
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	59/1820	181/9376	1.67926658976383	CD74/CTSS/FCGR2C/IL1B/ITGAX/CLEC7A/HLA-DQA2/CIITA/BID/RIPK2/MALT1/RAB7A/CORO1A/TLR2/PLA2R1/CLEC4E/SRC/IFNGR1/MYD88/IRAK2/VDR/MAPK8/NFKB1/HLA-DRB5/CAMK2D/C3/RHOA/NOD2/NFYC/MAPK1/PPP3CC/CASP8/CASP9/FCGR3B/BCL10/STAT1/CREB1/BCL2/PPP3CB/MAPK10/RAF1/IL1A/KSR1/MRC2/TGFB1/ATP6V0D1/CEBPB/IRAK4/ATP6V0B/MAPK14/SPHK1/ATP6V1H/TIRAP/HLA-DRA/IL10/HLA-DPA1/CAMP/IFNG/IL6	4.52875714504171
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	59/1820	187/9376	1.62538637832755	CARD16/NAMPT/IL1B/PLCB1/GBP5/RIPK2/CYBA/ITPR1/MAP1LC3B/ANTXR2/CXCL2/GBP4/TRAF3/CASP1/MYD88/GBP1/TNFAIP3/MAPK8/TXN/VDAC2/NFKB1/GABARAPL2/PYCARD/ATG5/TANK/AIM2/TAB2/MEFV/GABARAPL1/GBP2/RHOA/NOD2/VDAC3/MCU/NLRP3/MAPK1/CXCL8/CASP4/CASP8/STAT1/TBK1/VDAC1/BCL2/PANX1/MAPK10/NLRP1/BIRC3/NLRP12/ATG12/TICAM1/IRAK4/MAPK14/ERBIN/CXCL3/CASP5/MAP1LC3B2/IKBKE/CAMP/IL6	4.23945912771643
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	36/1820	100/9376	1.85459340659341	CD37/CD44/CSF3R/IL1B/HLA-DQA2/IL3RA/ITGA4/CD1D/CSF2RA/HLA-DRB5/CD22/CD38/CD9/CD7/ANPEP/CD55/IL7R/CD3D/CD3E/CD2/CD1C/IL1R1/IL1A/CD3G/ITGA5/CSF1/IL6R/FCER2/CD8A/CD5/FLT3LG/HLA-DRA/CD8B/HLA-DPA1/IL6/FLT3	4.216523502498
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	19/1820	42/9376	2.33050758765044	FTH1/SAT1/ACSL5/MAP1LC3B/VDAC2/ATG5/SLC7A11/ACSL1/VDAC3/PCBP1/ACSL3/ATG7/GCLM/ACSL4/CP/GCLC/PRNP/SLC39A8/MAP1LC3B2	4.24114831381602
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	41/1820	122/9376	1.73129165916051	FYN/PAK1/MALT1/MAP2K1/LCP2/MAPK8/NFKB1/KRAS/RHOA/PTPRC/MAPK1/PPP3CC/CARD11/BCL10/CD3D/PIK3CB/CD247/PPP3CB/CD3E/MAPK10/RAF1/CD3G/ITK/SOS2/PPP2R2A/PPP2R5C/NFATC3/MAP3K8/PRKCQ/MAPK14/GRAP2/LCK/RASGRP1/CD8A/PPP2R2B/LAT/PPP2R3A/CD8B/IL10/ICOS/IFNG	3.99007579319888
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	46/1820	142/9376	1.66884383222411	FCGR2C/FYN/IL1B/GAB2/TYROBP/CYBA/MAP2K1/ITPR1/LILRA5/IFNGR1/LCP2/JUND/MAPK8/NFKB1/RELB/SIRPB1/NCF2/TAB2/MAPK1/PPP3CC/FOSL1/FCGR3B/STAT1/RAC1/PIK3CB/PPARG/CREB1/PPP3CB/ATP2A3/MAPK10/IL1R1/IL1A/TGFB1/TGFBR1/TREM2/CAMK4/MAP2K6/MAPK14/CSF1/FOSL2/LCK/CYLD/IFNG/LILRB2/LILRA2/TMEM64	3.94138919080513
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	29/1820	78/9376	1.91535643843336	FCGR2C/IL1B/HLA-DQA2/EEF1A1/CYBA/ITGA4/TLR2/IFNGR1/MYD88/NFKB1/HLA-DRB5/PRKCB/C3/NCF2/MARCKSL1/TAB2/PTGS2/MAPK1/FCGR3B/STAT1/IL1A/TGFB1/IRAK4/MAPK14/ELK1/HLA-DRA/IL10/HLA-DPA1/IFNG	3.98398898138677
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	61/1820	204/9376	1.54044386985563	LUM/CD44/DCN/PAK1/ACTB/RPS6/PLAUR/THBS1/TIAM1/MAP2K1/ITPR1/HPSE/TLR2/CTNNB1/FLNA/SRC/HIF1A/PPP1CA/MSN/CAMK2D/PRKCB/KRAS/BRAF/WNT2B/RHOA/HCLS1/MAPK1/PDCD4/RRAS/CBL/ACTG1/RAC1/PIK3CB/IGF1R/COL1A1/HGF/SDC2/ESR1/FAS/ITGAV/NUDT16L1/RAF1/SMAD2/TGFB1/SOS2/PPP1CB/FZD1/ARAF/ITGA5/EZR/MAPK14/PPP1R12B/ELK1/CAV1/GPC3/SLC9A1/MET/CAV2/FZD2/IGF2/ANK3	3.83009030110265
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	72/1820	250/9376	1.48367472527473	ARF5/CXCR4/RAB7A/CHMP4B/ACTR3/ARPC3/SMAD3/SRC/IL2RG/RAB31/SH3KBP1/ARPC2/SNF8/CHMP1B/SMAP2/RAB11A/SMAP1/ARFGAP3/RAB4A/RHOA/VPS29/RAB8A/GRK6/CBL/EHD1/ARPC4/VPS37B/LDLR/CAPZA1/SMURF2/CCR5/IQSEC1/VPS26A/IGF1R/CHMP2B/PDCD6IP/ARPC1A/AGAP3/WIPF3/TSG101/ZFYVE16/SMAD2/RAB10/RAB22A/VPS35/DNM3/RAB11FIP1/TGFBR1/GBF1/RAB11FIP4/IGF2R/ARFGEF1/VPS37C/NEDD4L/AGAP2/HSPA6/FOLR3/ARAP3/PDGFRA/PRKCI/ARFGEF2/GRK5/PIP5K1B/CAV1/ARF6/ASAP1/PSD/CYTH1/CXCR2/PARD6A/CAV2/STAM	3.80415779789066
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	33/1820	93/9376	1.82800425381071	FYN/ACTB/RAC2/RAP1B/SMAD3/CTNNB1/SRC/MYL12A/RAP1A/MYL12B/VCL/PDCD10/RHOA/WAS/ACTN1/MAPK1/PTPRJ/PTPN1/ACTG1/SMURF2/RAC1/TCF7L2/IGF1R/FARP2/TGFBR1/MYL9/FER/LMO7/WASF2/SNAI1/YES1/MET/LEF1	3.93826761842781
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/1820	105/9376	1.76627943485086	TNFSF13B/IL1B/BCL2A1/MALT1/CXCL2/LYN/TRAF3/MYD88/TNFAIP3/NFKB1/RELB/PRKCB/CXCL12/TAB2/TRAF1/PTGS2/TNFSF14/ERC1/CXCL8/CARD11/BCL10/BCL2/IL1R1/BIRC3/VCAM1/PRKCQ/CCL4L2/TICAM1/IRAK4/LCK/CYLD/CXCL3/TIRAP/LAT/CARD14/TRIM25	3.87519790636229
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	36/1820	105/9376	1.76627943485086	IL1B/CLEC7A/PAK1/MALT1/ITPR1/CLEC4E/SRC/CASP1/MAPK8/NFKB1/RELB/PYCARD/KRAS/MAPKAPK2/RHOA/PTGS2/NLRP3/MAPK1/RRAS/PPP3CC/CASP8/BCL10/STAT1/PIK3CB/PPP3CB/CLEC4D/MAPK10/RAF1/KSR1/NFATC3/MAPK14/CYLD/CLEC6A/IKBKE/IL10/IL6	3.87519790636229
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	32/1820	90/9376	1.83169719169719	MAP2K1/TLR2/HIF1A/IFNGR1/MYD88/NFKB1/KRAS/MAP2K3/ALK/MAPK1/PPP3CC/STAT1/CD3D/PIK3CB/CD247/PPP3CB/CD3E/RAF1/BATF3/CD3G/PTEN/NFATC3/PRKCQ/TICAM1/MAP2K6/EML4/MAPK14/LCK/RASGRP1/TIRAP/LAT/IFNG	3.89087705148697
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	58/1820	196/9376	1.52446736936533	CLEC2B/RPS27A/UBA52/PIK3R5/BID/ATG3/MAP2K1/ITPR1/MAP1LC3B/CTNNB1/CXCL2/SRC/HIF1A/IFNGR1/LYN/TRAF3/GNG5/MAPK8/CD86/NFKB1/KRAS/C3/MAPKAPK2/PTGS2/MAPK1/HCK/GNB1/GNGT2/CXCL8/PPP3CC/CASP8/CASP9/CCR5/STAT1/RAC1/TCF7L2/PIK3CB/TBK1/CREB1/MAP2K4/PPP3CB/FAS/MAPK10/CDK6/RAF1/NFATC3/TICAM1/MAP2K6/MAPK14/GNG11/PIK3CG/CXCL3/MAP1LC3B2/ZFP36/PIK3R6/IKBKE/LEF1/IL6	3.64166947336294
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	48/1820	157/9376	1.57502624763771	MAP2K1/ITPR1/SMAD3/RASSF5/CAPN2/PPP1CA/VDAC2/NFKB1/CCND3/SLC25A5/KRAS/MAPKAPK2/RHEB/MAP2K3/ZFP36L2/HIPK2/SLC25A6/VDAC3/MCU/MAPK1/RRAS/CXCL8/PPP3CC/CCND2/PIK3CB/VDAC1/FBXW11/PPP3CB/CDK6/RAF1/SMAD2/IL1A/TGFB1/TGFBR1/NBN/PPP1CB/PTEN/RAD1/FOXO1/NFATC3/CACNA1D/MAP2K6/MAPK14/TRAF3IP2/HIPK1/BTRC/IL6/RAD9B	3.56591465885625
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	40/1820	125/9376	1.64852747252747	FYN/GAB2/PLCB1/BID/RAC2/MAP2K1/SGMS2/S1PR4/MAPK8/PRKCE/NFKB1/NSMAF/S1PR3/PRKCB/GNA12/KRAS/MAP3K5/GNAQ/RHOA/CERS6/MAPK1/GNA13/ORMDL1/RAC1/PIK3CB/BCL2/MAPK10/CERS5/RAF1/FCER1A/PPP2R2A/ASAH1/PTEN/PPP2R5C/MAPK14/CERS4/DEGS1/SPHK1/PPP2R2B/PPP2R3A	3.58232019795761
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	33/1820	98/9376	1.7347387306571	GAB2/PAK1/PLA2G6/RAC2/MAP2K1/ACTR3/ARPC3/LYN/ARPC2/PRKCE/PRKCB/MARCKSL1/WAS/PTPRC/CFL1/MAPK1/HCK/ARPC4/FCGR3B/RAC1/PIK3CB/ARPC1A/RAF1/GSN/PLA2G4A/PLPP1/PIP5K1B/ARF6/SPHK1/WASF2/ASAP1/MYO10/LAT	3.58834461585442
Organismal Systems	Immune system	hsa04611	Platelet activation	40/1820	126/9376	1.63544392115821	FYN/PLCB1/PIK3R5/ACTB/ITPR1/RAP1B/SRC/LYN/LCP2/ADCY3/PPP1CA/MYL12A/RAP1A/MYL12B/TBXAS1/P2RX1/COL3A1/RASGRP2/APBB1IP/GNAQ/RHOA/MAPK1/GNA13/ACTG1/PIK3CB/STIM1/COL1A1/PTGIR/GUCY1A1/VWF/ADCY9/PPP1CB/PRKG1/MAPK14/PLA2G4A/PIK3CG/PRKCI/RASGRP1/PIK3R6/P2RY12	3.5242523111962
NA	NA	hsa04517	IgSF CAM signaling	81/1820	299/9376	1.39559704509537	CD48/JAML/FYN/ITGAX/PAK1/ACTB/ICAM3/MAP2K1/RAP1B/ITGA4/ICAM2/ACTR3/ARPC3/CTNNB1/CRTAM/TUBA4A/SRC/LYN/SLAMF7/LCP2/MYL6/MAPK8/MSN/MYL12A/RAP1A/ARPC2/MYL12B/CD86/MBP/CD244/ROBO1/PRKCB/VCL/CSK/RHOA/ACTN1/IL1RAPL2/MAPK1/ERC1/LY9/RAPGEF2/ARPC4/ACTG1/UNC5B/RAC1/PIK3CB/CADM1/NCAM1/ARPC1A/CD80/CD96/CD226/CD2/MAPK10/SLIT2/TRIO/DYNLL1/IL1RAP/CADM3/MYL9/FOXO1/TUBB6/PRKCQ/LMO7/ITGA5/EZR/MAPK14/LCK/PRKCI/NTRK3/ARF6/GRIP1/MAGI2/SH2D1A/SLAMF1/PARD6A/KCNQ3/GLDN/SLIT3/TIGIT/ANK3	3.41187273224839
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	65/1820	232/9376	1.44334975369458	CYRIB/CYRIA/ITGAX/PAK1/CXCR4/ACTB/DIAPH1/TIAM1/RAC2/MAP2K1/ITGA4/ACTR3/ARPC3/TMSB4X/SRC/LPAR1/SSH2/ITGAE/PPP1CA/MSN/MYL12A/ARPC2/MYL12B/C7/PFN1/GNA12/SPATA13/BRK1/KRAS/CYFIP2/VCL/BRAF/CXCL12/RHOA/CFL1/ACTN1/MAPK1/RRAS/ITGB8/ARPC4/GNA13/ACTG1/RAC1/PIK3CB/PIP4K2A/ARPC1A/ITGAV/RAF1/ITGAD/SOS2/PPP1CB/MYL9/ITGB7/DIAPH2/ARAF/GSN/ITGA5/EZR/PPP1R12B/PDGFRA/PIP5K1B/WASF2/C5/ITGB4/SLC9A1	3.35581269654189
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	47/1820	157/9376	1.54221320081193	CX3CR1/THBS1/PLA2G6/GPR132/PTGER2/MAP2K1/RAB7A/ATP11B/HIF1A/CASP1/UQCRFS1/RXRA/PTGER4/LIPA/CAMK2D/SIRPB1/MAPKAPK2/ELMO1/SGK1/PTGS2/MAPK1/SIGLEC10/ADAM17/PECAM1/ATP8A1/RAC1/PPARG/CREB1/PANX1/ATP2A3/VPS8/ITGAV/RAB7B/TGFB1/P2RY2/NFATC3/CEBPB/MAPK14/ODC1/MFGE8/HAVCR1/SPHK1/AXL/DUSP5/IL10/P2RY12/XKR8	3.36243086110181
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	14/1820	31/9376	2.32655086848635	SEC11A/SEC61G/SEC61B/SEC11C/SPCS1/IMMP2L/SEC62/SRP72/SRP9/SPCS3/OXA1L/SPCS2/SRP14/SRP19	3.63070079166817
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	27/1820	78/9376	1.7832628909552	ACTB/ACTR3/ARPC3/CTNNB1/SRC/ARPC2/VCL/ELMO1/SEPTIN6/RHOA/HCLS1/RHOG/CBL/ARPC4/ACTG1/RAC1/PIK3CB/MAD2L2/SEPTIN1/ARPC1A/DNM3/ITGA5/ARHGAP10/CAV1/WASF2/MET/CAV2	3.40906623482699
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/1820	56/9376	1.93186813186813	IL1B/EEF1A1/TLR2/CXCL2/CASP1/MYD88/NFKB1/PYCARD/C3/RAB1A/SAR1B/BCL2L13/CXCL8/CASP8/CASP9/SEC22B/SAR1A/HBS1L/HSPA6/CXCL3/IL6	3.43254211803844
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	55/1820	193/9376	1.46808631782725	CX3CR1/FGR/PAK1/PLCB1/PIK3R5/CXCR4/TIAM1/RAC2/MAP2K1/RAP1B/CXCL2/SRC/LYN/GNG5/ADCY3/RAP1A/NFKB1/PTK2B/PRKCB/DOCK2/KRAS/RASGRP2/ELMO1/BRAF/CXCL12/GNAQ/RHOA/WAS/MAPK1/HCK/GNB1/GNGT2/CXCL8/GRK6/CXCL14/CCR5/STAT1/RAC1/XCL2/PIK3CB/XCL1/CCR2/RAF1/ADCY9/ITK/SOS2/CCL4L2/GNG11/CCR7/PIK3CG/GRK5/STAT5B/CXCL3/CXCR2/PIK3R6	3.22468774247139
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	37/1820	119/9376	1.60177301689907	IL1B/IL15/MAP2K1/CREB5/CXCL2/TRAF3/TNFAIP3/MAPK8/NFKB1/MAP2K3/MAP3K5/TAB2/TRAF1/NOD2/PTGS2/MAPK1/ADAM17/CASP8/TNFRSF1B/PIK3CB/CREB1/MAP2K4/FAS/MAPK10/BIRC3/RPS6KA5/CEBPB/MAP3K8/VCAM1/MAP2K6/MAPK14/CSF1/IL18R1/CYLD/CXCL3/EDN1/IL6	3.24224938662516
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	33/1820	103/9376	1.65052811266404	IL1B/PLCB1/TLR2/IFNGR1/GNAL/MYD88/MAPK8/NFKB1/C3/GNAQ/MAPK1/CXCL8/CASP8/CD3D/PIK3CB/CD247/MAP2K4/FAS/CD3E/MAPK10/SMAD2/CD3G/TGFB1/PPP2R2A/TGFBR1/TICAM1/IRAK4/MAPK14/ACE/PPP2R2B/IL10/IFNG/IL6	3.25799121880257
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	43/1820	144/9376	1.53833943833944	PLCB1/PPIF/ERN1/ITPR1/PSMA4/MAPK8/VDAC2/PSMA5/SLC25A5/PRKCB/ATXN1/PSMA7/MAP3K5/PSMB1/GNAQ/AMBRA1/SLC25A6/PSMB7/WIPI1/ATXN10/VDAC3/MCU/ATXN3/TBPL1/PSMD8/OPA1/PSMB6/PSMB2/PSMD4/PIK3CB/VDAC1/SEM1/PSMD12/KCNC3/RORA/ATP2A3/PSMD9/MAPK10/NRBF2/ATG2A/BEAN1/RB1CC1/TBP	3.19495615608075
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	35/1820	112/9376	1.60989010989011	HLA-DQA2/PIK3R5/CIITA/PPIF/TLR2/IFNGR1/MYD88/MAPK8/NFKB1/HLA-DRB5/MAP2K3/TAB2/LAMB3/MAPK1/CASP8/CASP9/LDLR/CCR5/STAT1/BCL2/LAMA2/MAPK10/BIRC3/TGFB1/IRAK4/MAP2K6/MAPK14/HSPA6/PIK3CG/PIK3R6/HLA-DRA/IL10/HLA-DPA1/IFNG/LAMA4	3.18666702588536
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	56/1820	200/9376	1.44246153846154	RPS3/FYN/IL1B/PAK1/ACTB/ACTR3/ARPC3/TUBA4A/SRC/LPAR1/CASP1/MYD88/MAPK8/ARPC2/NFKB1/PYCARD/GNA12/BRK1/CYFIP2/SEC24A/RAB1A/TAB2/RHOA/HCLS1/NLRP3/MAPK1/MYO1G/TMED10/CXCL8/CASP4/CASP8/ARPC4/CASP9/GAPDH/SEC24B/GNA13/ACTG1/RAC1/ARPC1A/WIPF3/FAS/MAPK10/IL1R1/ABI1/MYO1F/TUBB6/IRAK4/EZR/MAPK14/ARF6/WASF2/CYTH1/MYO10/TNFSF10/TIRAP/IL6	3.10412483188668
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	30/1820	93/9376	1.66182204891882	HLA-DQA2/MAML3/STAT4/IFNGR1/RUNX3/IL2RG/MAPK8/NFKB1/HLA-DRB5/NOTCH2/MAPK1/PPP3CC/STAT1/CD3D/CD247/PPP3CB/CD3E/MAPK10/MAML2/IL12RB1/CD3G/NFATC3/PRKCQ/MAPK14/LCK/STAT5B/LAT/HLA-DRA/HLA-DPA1/IFNG	3.14784897833921
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	47/1820	163/9376	1.48544461673296	BID/MAP2K1/TLR2/STAT4/SMAD3/CREB5/SRC/TRAF3/MYD88/MAPK8/NFKB1/PTK2B/PRKCB/KRAS/MAP2K3/BRAF/TAB2/VDAC3/MAPK1/CXCL8/CASP8/CASP9/SLC10A1/STAT1/PIK3CB/TBK1/CREB1/MAP2K4/BCL2/FAS/YWHAZ/MAPK10/RAF1/TGFB1/SOS2/TGFBR1/NFATC3/ARAF/TICAM1/IRAK4/MAP2K6/MAPK14/STAT5B/ELK1/TIRAP/IKBKE/IL6	3.06837413789025
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	23/1820	66/9376	1.7952713952714	IL1B/HLA-DQA2/TLR2/STAT4/SMAD3/IFNGR1/IL2RG/NFKB1/HLA-DRB5/NOD2/STAT1/RORA/IL21R/SMAD2/IL1A/IL12RB1/TGFB1/IL18R1/HLA-DRA/IL10/HLA-DPA1/IFNG/IL6	3.18190967137266
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	49/1820	174/9376	1.45075154730327	MARCHF6/EIF2AK3/ERN1/SEC61G/SSR4/CAPN2/MAPK8/TMEM258/SEC61B/SSR2/ERP29/UBE2D1/DNAJC5B/CKAP4/STT3B/UBE2J1/SEC62/RBX1/SEC24A/DNAJA2/OSTC/CRYAB/MAP3K5/SAR1B/SSR3/UBE2D2/DNAJC3/SSR1/SEC13/UFD1/DNAJC1/ATXN3/CUL1/SEC31A/DERL1/PLAA/DAD1/SEC24B/BAG1/SAR1A/DERL2/BCL2/UBXN1/MAPK10/FBXO6/NGLY1/SVIP/HSPA6/UBE4B	2.94541228207721
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	36/1820	120/9376	1.54549450549451	IRAK3/RIPK2/MAP2K1/RAP1B/ARHGDIB/IRAK2/MAPK8/RAP1A/NFKB1/CAMK2D/RPS6KA3/RAPGEF1/KRAS/MAPKAPK2/BRAF/MAP3K5/RHOA/MAPK1/PSEN1/RAC1/PIK3CB/MAP2K5/BCL2/MAPK10/SH2B2/RAF1/RPS6KA5/SOS2/SORT1/CAMK4/MATK/SH2B3/IRAK4/MAPK14/NTRK3/ZNF274	2.95151291643936
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	58/1820	214/9376	1.39624114203553	APOBEC3A/PAK1/CXCR4/ELOB/AP1S2/BID/RAC2/MAP2K1/ITPR1/TLR2/RNF7/MYD88/GNG5/MAPK8/NFKB1/PTK2B/PRKCB/KRAS/APOBEC3B/RBX1/MAP2K3/TAB2/GNAQ/APOBEC3G/CFL1/AP1G1/MAPK1/GNB1/GNGT2/CUL1/PPP3CC/CASP8/CASP9/ELOC/TNFRSF1B/CCR5/RAC1/CD3D/PIK3CB/CD247/TBK1/FBXW11/BCL2/PPP3CB/FAS/CD3E/MAPK10/CUL4A/RAF1/CD3G/NFATC3/IRAK4/MAP2K6/MAPK14/GNG11/TRIM5/APOBEC3F/BTRC	2.8777076228349
NA	NA	hsa04518	Integrin signaling	44/1820	154/9376	1.47189952904239	ITGAX/ACTB/LIMS1/THBS1/RAC2/ICAM3/ITGA4/ICAM2/CTNNB1/FLNA/SRC/ITGAE/CCND3/C3/VCL/LAMB3/ACTN1/COL6A2/PARVG/COL6A1/ITGB8/CCND2/ACTG1/RAC1/PIK3CB/PARVB/IGF1R/COL1A1/HGF/LAMA2/ITGAV/ITGAD/COL6A3/VWF/TGFB1/ITGB7/COL9A2/VCAM1/ITGA5/PDGFRA/FLNB/ITGB4/MET/LAMA4	2.89782865738347
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/1820	46/9376	1.90387004300048	PSMA4/PSMA5/POMP/PSMA7/PSMB1/PSMB7/PSMB10/PSME4/PSMD8/PSMB6/PSMB2/PSMD4/SEM1/PSMD12/PSMD9/PSMB9/IFNG	3.01591740994705
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	58/1820	216/9376	1.38331298331298	IL1B/EIF2AK3/PLCB1/BID/CYBA/OLR1/ERN1/ITPR1/RAP1B/TLR2/CXCL2/SRC/LYN/TRAF3/CASP1/MYD88/MAPK8/RAP1A/RXRA/NFKB1/CAMK2D/PYCARD/KRAS/TANK/NCF2/SOD2/MAP2K3/MAP3K5/TAB2/RHOA/NLRP3/MAPK1/CXCL8/PPP3CC/CASP8/CASP9/LDLR/RAC1/PIK3CB/PPARG/TBK1/MAP2K4/BCL2/PPP3CB/FAS/MAPK10/NFATC3/VCAM1/TICAM1/IRAK4/MAP2K6/MAPK14/HSPA6/CXCL3/TNFSF10/TIRAP/IKBKE/IL6	2.79710021053078
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1820	32/9376	2.09285714285714	ATG3/IGBP1/GABARAPL2/ATG5/GABARAPL1/WIPI1/RPTOR/ATG7/ATG2A/ATG10/ATG12/ATG4A/ATG4D	3.03911634991176
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	13/1820	33/9376	2.02943722943723	STX11/VAMP5/VTI1A/STX8/STX5/STX18/BET1L/VAMP3/SEC22B/STX3/BET1/VAMP4/STX1B	2.90729447842968
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	76/1820	300/9376	1.30508424908425	IL1B/MAP3K20/PAK1/RAC2/MAP4K3/MAP2K1/RAP1B/FLNA/JUND/MYD88/MAPK8/EREG/RAP1A/MAP4K4/MAP3K2/NFKB1/RELB/PRKCB/GNA12/RPS6KA3/KRAS/RASGRP2/MAPKAPK2/MAP2K3/BRAF/MAP3K5/TAB2/PTPN7/DUSP6/MAPK1/RRAS/PPP3CC/MAPKAPK3/RAPGEF2/RAC1/IGF1R/HGF/MAP2K4/MAP2K5/STK3/PPP3CB/FAS/MAPK10/IL1R1/RAF1/IL1A/EFNA5/RPS6KA5/TGFB1/SOS2/TGFBR1/IL1RAP/ELK4/NFATC3/CACNA1D/MAP3K8/AREG/ARAF/IRAK4/MAP2K6/MECOM/MAPK14/CSF1/PLA2G4A/HSPA6/PDGFRA/RASA2/MAP3K21/ELK1/RASGRP1/FLT3LG/DUSP5/MET/CACNA1G/FLT3/IGF2	2.63577617321926
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	52/1820	195/9376	1.37377289377289	H3-3B/H3-3A/MACROH2A1/H2AZ1/H2AZ2/AQP9/H2AJ/CLEC7A/H2AC20/PLCB1/ACTB/H4C3/RAC2/PPIF/CYBA/MAP2K1/FPR1/TLR2/SRC/CASP1/VDAC2/NFKB1/C5AR1/SLC25A5/MACROH2A2/PRKCB/C3/NCF2/H2AX/SLC25A6/PADI4/VDAC3/MAPK1/CASP4/HDAC4/FCGR3B/ACTG1/RAC1/PIK3CB/HDAC1/VDAC1/HDAC9/ATG7/RAF1/VWF/FPR3/FPR2/MAPK14/H4C5/C5/MPO/CAMP	2.58854352879653
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	31/1820	105/9376	1.52096284667713	RPS27A/UBA52/TOMM7/EIF2AK3/RAB7A/MAP1LC3B/CALCOCO2/SRC/HIF1A/MARCHF5/TOMM20/MAPK8/PHB2/GABARAPL2/KRAS/ARIH1/AMBRA1/GABARAPL1/BCL2L13/RRAS/OPA1/SMURF2/TBK1/RHOT1/MAPK10/TAX1BP1/RAB7B/TBC1D15/CCZ1B/USP15/MAP1LC3B2	2.6345926054099
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	30/1820	101/9376	1.53019257969753	IL1B/PLCB1/DIAPH1/SMAD3/MAPK8/PRKCE/NFKB1/PRKCB/KRAS/COL3A1/MAPK1/CXCL8/STAT1/RAC1/PIK3CB/COL1A1/BCL2/MAPK10/SMAD2/IL1A/TGFB1/TGFBR1/FOXO1/VCAM1/MAPK14/CDKN1B/STAT5B/F3/EDN1/IL6	2.62913405498272
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/1820	85/9376	1.57579831932773	ADSS2/CDA/ADK/UPP1/ENTPD1/ADA/PNP/APRT/NME3/DGUOK/AMPD2/NT5C2/NT5C3A/GUK1/DUT/HPRT1/GMPS/ASMTL/RRM1/NME7/ENPP1/UCKL1/TYMP/UCK2/NT5E/ADSS1	2.61712209077833
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	58/1820	224/9376	1.33390894819466	IL15/HLA-DQA2/TSPO/MAP2K1/SMAD3/CREB5/CDC26/IL2RG/ADCY3/MAPK8/VDAC2/NFKB1/RELB/HLA-DRB5/CCND3/SLC25A5/KRAS/SLC25A6/VDAC3/MAPK1/TBPL1/PPP3CC/FOSL1/ANAPC16/CCND2/ANAPC15/CD3D/PIK3CB/CREB1/MAP2K4/VDAC1/POLB/PPP3CB/CD3E/MAPK10/RAN/IL1R1/SMAD2/CDC27/CD3G/ADCY9/TGFB1/TGFBR1/ELK4/PTEN/NFATC3/CRTC3/LCK/STAT5B/ELK1/ZFP36/PTTG1/HLA-DRA/HLA-DPA1/IL6/TBP/KAT2B/MAD2L1	2.48238660188724
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1820	115/9376	1.47829909221214	NACA/PDE4B/PLCB1/MAP2K1/ITPR1/PDE4A/CREB5/STK39/JUND/OXSR1/VDR/ADCY3/RXRA/MMP24/RUNX2/PRKCB/GNA12/BRAF/GNAQ/PDE4D/SGK1/RHOA/MAPK1/GNA13/MEF2D/CREB1/BCL2/RAF1/ADCY9/ARAF/AKAP13/MMP25/NACA2	2.53276497757429
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	24/1820	78/9376	1.58512256973795	IL1B/CASP1/MYD88/MAPK8/NFKB1/PYCARD/C3/RHOA/CFL1/IRF8/NLRP3/MAPK1/CXCL8/MAPK10/IL1A/TICAM1/IRAK4/ITGA5/MAPK14/C1S/C5/TIRAP/IL10/IL6	2.54668211498731
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1820	70/9376	1.61908948194662	PAK1/ELOB/MAP2K1/RAP1B/HIF1A/RAP1A/RAPGEF1/KRAS/RBX1/BRAF/MAPK1/ELOC/RAC1/PIK3CB/CUL2/HGF/RAF1/VHL/TGFB1/SOS2/ARAF/MET	2.5515041502202
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	55/1820	212/9376	1.33651254405971	SIPA1L1/PLCB1/ACTB/THBS1/TIAM1/RAC2/MAP2K1/FPR1/RAP1B/RASSF5/CTNNB1/SRC/LPAR1/LCP2/ADCY3/RAP1A/DOCK4/PFN1/PRKCB/RAPGEF1/KRAS/RASGRP2/MAP2K3/APBB1IP/BRAF/GNAQ/RHOA/RALA/MAPK1/RRAS/RAPGEF2/ACTG1/SIPA1L3/RAC1/PIK3CB/IGF1R/HGF/FARP2/SKAP1/RAF1/FYB1/EFNA5/ADORA2B/ADCY9/MAP2K6/MAPK14/CSF1/ARAP3/PDGFRA/PRKCI/MAGI2/PARD6A/LAT/MET/ADORA2A	2.43221524160952
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	37/1820	133/9376	1.43316533090969	CD48/FYN/PAK1/BID/RAC2/TYROBP/MAP2K1/ICAM2/IFNGR1/LCP2/LAT2/HCST/CD244/PTK2B/GZMB/PRKCB/KLRD1/KRAS/BRAF/MAPK1/PPP3CC/FCGR3B/RAC1/PIK3CB/CD247/PRF1/PPP3CB/FAS/RAF1/SOS2/KLRC1/ARAF/LCK/SH2D1A/TNFSF10/LAT/IFNG	2.4691552160549
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	39/1820	142/9376	1.4148893360161	IL1B/ACTB/RAC2/GSTP1/CYBA/CTNNB1/SRC/MGST1/SUMO2/GSTO1/MAPK8/TXN/NFKB1/NCF2/MAP3K5/SUMO1/RHOA/PECAM1/ACTG1/RAC1/PIK3CB/MAP2K4/SDC2/MAP2K5/BCL2/MAPK10/ITGAV/IL1R1/IL1A/VCAM1/MAP2K6/MAPK14/ACVR1/CAV1/MGST3/EDN1/NQO1/IFNG/CAV2	2.44487616625914
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	46/1820	173/9376	1.36980245188338	IL1B/HLA-DQA2/ACTB/CIITA/BID/MAP2K1/CALCOCO2/IFNGR1/TRAF3/CASP1/MYD88/NFKB1/HLA-DRB5/CCND3/SLC25A5/PYCARD/PRKCB/NXT1/RAB11A/SLC25A6/DNAJC3/NUP98/NLRP3/MAPK1/CXCL8/CASP8/CASP9/ACTG1/STAT1/PIK3CB/TBK1/VDAC1/FAS/CDK6/RAF1/IL1A/RAE1/TICAM1/IRAK4/TNFSF10/IKBKE/HLA-DRA/HLA-DPA1/IFNG/IL6/TRIM25	2.40936992212372
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1820	71/9376	1.59628540473611	PAK1/CXCL2/SRC/LYN/MAPK8/NFKB1/ATP6V1G1/CSK/CXCL8/ADAM17/RAC1/MAP2K4/MAPK10/ATP6V0E1/ATP6V0D1/ATP6V0B/MAPK14/ATP6V1B2/CXCL3/ATP6V1H/CXCR2/MET	2.47514429565612
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	53/1820	205/9376	1.33188957384079	VIM/CD44/HLA-DQA2/BID/ENTPD1/TLR2/LYN/RUNX3/TRAF3/HES1/MYD88/TNFAIP3/MAPK8/NFKB1/RELB/HLA-DRB5/CCND3/CD58/MAP2K3/TAB2/PSMD8/SAP30/CASP8/CASP9/CCND2/PSMD4/STAT1/RAC1/CD3D/PIK3CB/CD247/TBK1/HDAC1/MAP2K4/SEM1/PSMD12/BCL2/FAS/CD3E/MAPK10/CIR1/CDK6/CD3G/NCOR2/IRAK4/MAP2K6/MAPK14/CDKN1B/FCER2/IKBKE/HLA-DRA/HLA-DPA1/IL6	2.35796606629693
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	44/1820	166/9376	1.36549715344896	PLCB1/PIK3R5/PPIF/MAP2K1/ITPR1/ATP2B1/CREB5/ADCY3/PPP1CA/VDAC2/PRKCE/SLC25A5/KCNMB4/GNA12/SLC8A1/GNAQ/SLC25A6/RGS2/RHOA/VDAC3/MAPK1/PPP3CC/GNA13/KCNMB1/MEF2D/CREB1/VDAC1/PPP3CB/KCNMA1/ATP2A3/RAF1/GUCY1A1/ADCY9/PPP1CB/MYL9/NFATC3/CACNA1D/PDE2A/PRKG1/PIK3CG/PDE3A/PIK3R6/PDE5A/PDE3B	2.33175859052983
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	19/1820	60/9376	1.63135531135531	RAC2/MAP2K1/SRC/PRKCB/KRAS/MAPKAPK2/PTGS2/MAPK1/PPP3CC/MAPKAPK3/CASP9/RAC1/PIK3CB/PPP3CB/RAF1/MAPK14/PLA2G4A/SPHK1/SH2D2A	2.40774273548442
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	35/1820	128/9376	1.40865384615385	ADSS2/PDE4B/ADK/ENTPD1/PDE4A/ADA/ADCY3/PNP/PDE7A/APRT/NME3/DGUOK/NUDT2/PDE8A/PDE4D/AMPD2/NT5C2/GUK1/HPRT1/GMPS/PDE7B/FHIT/GUCY1A1/ADCY9/PAPSS2/RRM1/PDE6D/PDE2A/NME7/ENPP1/PDE3A/PDE5A/PDE3B/NT5E/ADSS1	2.2846097326887
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	13/1820	37/9376	1.81003861003861	IL1B/PLCB1/IDO2/MYD88/PRKCB/GNAQ/FAS/VCAM1/IDO1/IL10/IFNG/IL6/LAMA4	2.42287914459687
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	27/1820	94/9376	1.47972878185644	S100A8/IL1B/S100A9/CXCL2/TRAF3/JUND/TNFAIP3/MAPK8/NFKB1/MAPK6/TAB2/PTGS2/USP25/MAPK1/CXCL8/FOSL1/CASP8/TBK1/IL17RA/MAPK10/CEBPB/MAPK14/TRAF3IP2/CXCL3/IKBKE/IFNG/IL6	2.29411020892605
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	44/1820	168/9376	1.34924123495552	MACROH2A1/FTH1/H2AZ1/H2AZ2/H2AJ/IL1B/H2AC20/BID/CHMP4B/STAT4/CAPN2/IFNGR1/CASP1/TNFAIP3/MAPK8/VDAC2/SLC25A5/CAMK2D/MACROH2A2/PYCARD/CHMP1B/H2AX/SLC25A6/VDAC3/NLRP3/GLUD1/CASP8/STAT1/VDAC1/CHMP2B/BCL2/FAS/MAPK10/BIRC3/IL1A/ZBP1/SPATA2L/TICAM1/PLA2G4A/STAT5B/CYLD/GLUL/TNFSF10/IFNG	2.24167608370844
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	21/1820	69/9376	1.56789297658863	FYN/GAB2/RAC2/MAP2K1/LYN/LCP2/MAPK8/KRAS/MAP2K3/MAPK1/RAC1/PIK3CB/MAP2K4/MAPK10/RAF1/FCER1A/SOS2/MAP2K6/MAPK14/PLA2G4A/LAT	2.32360094036139
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	36/1820	133/9376	1.394431132777	MAP2K1/SMAD3/S1PR4/MAPK8/CDKN2D/GABARAPL2/PRKAG2/BCL6/KRAS/SOD2/BRAF/SGK1/GABARAPL1/MAPK1/HOMER1/CCND2/IL7R/PIK3CB/IGF1R/C8orf44-SGK3/MAPK10/RAF1/TGFB1/SOS2/TGFBR1/PTEN/FOXO1/ATG12/ARAF/MAPK14/AGAP2/CDKN1B/TNFSF10/HOMER2/IL10/IL6	2.24836019730723
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	15/1820	45/9376	1.71721611721612	IL1B/HLA-DQA2/CD86/HLA-DRB5/GZMB/KLRD1/PRF1/CD80/FAS/IL1A/KLRC1/HLA-DRA/HLA-DPA1/IFNG/IL6	2.36683269639207
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	41/1820	155/9376	1.36269408011343	CTSS/FCGR2C/CLEC7A/HLA-DQA2/ACTB/THBS1/CYBA/OLR1/RAB7A/CORO1A/TLR2/SEC61G/PLA2R1/TUBA4A/MSR1/SEC61B/HLA-DRB5/ATP6V1G1/C3/STX18/NCF2/DYNC1LI1/VAMP3/FCGR3B/SEC22B/ACTG1/RAC1/ATP6V0E1/ITGAV/MRC2/RAB7B/ATP6V0D1/TUBB6/ITGA5/ATP6V0B/ATP6V1B2/ATP6V1H/MPO/FCAR/HLA-DRA/HLA-DPA1	2.23456330517498
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	29/1820	103/9376	1.45046409900779	IL1B/PLCB1/RAB7A/TLR2/SERPINB9/CD1D/CXCL2/GNAL/NFKB1/PRKCB/COL3A1/VCL/GNAQ/LAMB3/ACTN1/CXCL8/PIK3CB/COL1A1/LAMA2/CD1C/IL1R1/SERPINB10/RAB7B/TGFB1/CXCL3/IL10/IFNG/IL6/LAMA4	2.2560256050166
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	32/1820	116/9376	1.42114437286851	TKT/FBP1/TALDO1/MDH2/HK2/SDHB/ESD/SUCLG1/PCCA/IDH3G/SDS/PGLS/PGD/SDSL/ACAT2/IDH3B/GLUD1/ME3/HK1/GAPDH/PGAM1/G6PD/RPIA/TKTL1/IDH3A/SUCLG2/PGK1/ENO4/OGDH/IDNK/PSPH/PC	2.23990635058761
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	26/1820	91/9376	1.47189952904239	RAC2/MALT1/MAP2K1/IFITM1/CD72/LILRA5/LYN/NFKB1/CD22/PRKCB/KRAS/MAPK1/PPP3CC/CD79B/CARD11/BCL10/RAC1/PIK3CB/PPP3CB/RAF1/BANK1/SOS2/NFATC3/DAPP1/LILRB2/LILRA2	2.22000853230128
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	25/1820	87/9376	1.48035872173803	RAC2/MAP2K1/SMAD3/CTNNB1/MAPK8/EREG/KRAS/BRAF/RHOA/RALA/MAPK1/CASP9/RAC1/TCF7L2/PIK3CB/BCL2/MAPK10/RAF1/SMAD2/TGFB1/SOS2/TGFBR1/AREG/ARAF/LEF1	2.20910410620905
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	16/1820	50/9376	1.64852747252747	TNFSF13B/IL15/HLA-DQA2/CXCR4/ITGA4/CD86/HLA-DRB5/CXCL12/CD80/TGFB1/ITGB7/HLA-DRA/IL10/HLA-DPA1/ICOS/IL6	2.25652958731862
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/1820	31/9376	1.82800425381071	TKT/RBKS/FBP1/TALDO1/PGLS/PGD/DERA/G6PD/RPIA/TKTL1/IDNK	2.26620461471287
Human Diseases	Infectious disease: viral	hsa05162	Measles	36/1820	136/9376	1.36367162249515	IL1B/RACK1/BID/TLR2/EIF3H/IL2RG/TRAF3/MYD88/TNFAIP3/MAPK8/MSN/NFKB1/CCND3/TAB2/RAB9A/CASP8/CASP9/CCND2/STAT1/CD3D/PIK3CB/TBK1/BCL2/FAS/CD3E/MAPK10/CDK6/IL1A/CD3G/IRAK4/HSPA6/CDKN1B/STAT5B/SLAMF1/IKBKE/IL6	2.09661283571915
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/1820	59/9376	1.57168932762153	CDA/DPYD/UPP1/ENTPD1/NME3/NUDT2/NT5C2/NT5C3A/DUT/ASMTL/UPB1/RRM1/NME7/ENPP1/UCKL1/TYMP/UCK2/NT5E	2.1618392644601
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	56/1820	227/9376	1.27089122331413	IL1B/PLCB1/CXCR4/BID/RAC2/PTGER2/MAP2K1/ITPR1/CTNNB1/CREB5/SRC/GNG5/ADCY3/PTGER4/NFKB1/PTK2B/PRKCB/GNA12/KRAS/RHEB/CXCL12/GNAQ/RHOA/PTGS2/MAPK1/GNB1/GNGT2/CXCL8/PPP3CC/CASP8/CASP9/GNA13/CCR5/RAC1/PIK3CB/TBK1/CREB1/PPP3CB/FAS/ITGAV/IL1R1/CDK6/RAF1/ADCY9/SOS2/NFATC3/CCL4L2/MAP2K6/MAPK14/GNG11/IL6R/PDGFRA/ELK1/CXCR2/AKAP13/IL6	2.02766594321314
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	7/1820	17/9376	2.12126696832579	MARS1/KYAT3/TXNRD1/PAPSS2/PSTK/TXNRD3/CTH	2.27087967345199
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	16/1820	52/9376	1.58512256973795	TSPO/VAPA/VDAC2/LIPA/SOAT1/STARD3NL/VDAC3/LDLR/VDAC1/LPL/APOE/OSBPL5/SORT1/LIPC/NPC1/APOC1	2.07645606897399
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	35/1820	134/9376	1.34557979334099	PRKCH/PLCB1/PLA2G6/MAP2K1/ITPR1/ADCY3/MYL6/PPP1CA/PRKCE/KCNMB4/PRKCB/GNA12/BRAF/GNAQ/RHOA/MAPK1/GNA13/KCNMB1/CALCRL/KCNMA1/PTGIR/RAF1/GUCY1A1/ADORA2B/ADCY9/PPP1CB/MYL9/CACNA1D/PRKCQ/ARAF/PRKG1/PLA2G4A/PPP1R12B/EDN1/ADORA2A	1.97739355926247
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/1820	99/9376	1.404995004995	PRKCH/IL1B/PLCB1/PLA2G6/PTGER2/ITPR1/SRC/ADCY3/PPP1CA/MAPK8/PRKCE/PTGER4/CAMK2D/PRKCB/MAP2K3/GNAQ/PIK3CB/MAPK10/IL1R1/ADCY9/P2RY2/IL1RAP/PPP1CB/PRKCQ/MAP2K6/MAPK14/PLA2G4A	1.98810282967908
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/1820	21/9376	1.96253270538985	CSGALNACT2/CHST11/DSE/CHST13/CHST15/UST/CHST7/CHST12	2.16709826338172
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	37/1820	144/9376	1.32368742368742	IL1B/CTNNB1/CXCL2/ALDH2/TRAF3/MYD88/MAPK8/NFKB1/C5AR1/PRKAG2/C3/MAP2K3/MAP3K5/TAB2/CAMKK2/LPIN1/CXCL8/CASP8/TCF7L2/TBK1/MAP2K4/IL17RA/FAS/MAPK10/FOXO1/LPIN2/TICAM1/IRAK4/MAP2K6/MAPK14/CXCL3/C5/TIRAP/IKBKE/ACACB/LEF1/IL6	1.92103170101385
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	32/1820	122/9376	1.35125202666186	PLCB1/ACTB/MAP2K1/CTNNB1/SRC/MED30/HIF1A/RXRA/NOTCH2/PRKCB/KRAS/RHEB/MAPK1/MED27/CASP9/MED13L/ACTG1/STAT1/PIK3CB/HDAC1/ESR1/NCOA3/NCOA2/ATP2A3/ITGAV/RAF1/NCOA1/FOXO1/MED13/SLC9A1/THRB/KAT2B	1.91650238497787
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	29/1820	109/9376	1.37062203851195	IL1B/MAP2K1/TLR2/TRAF3/MYD88/MAPK8/CD86/NFKB1/MAP2K3/TAB2/MAPK1/CXCL8/CASP8/STAT1/RAC1/PIK3CB/TBK1/MAP2K4/CD80/MAPK10/MAP3K8/CCL4L2/TICAM1/IRAK4/MAP2K6/MAPK14/TIRAP/IKBKE/IL6	1.91007431882078
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	20/1820	70/9376	1.47189952904239	FYN/HLA-DQA2/ACTB/SNTB1/BID/RAC2/CD86/HLA-DRB5/CD55/CASP8/CASP9/ACTG1/RAC1/PRF1/CD80/LAMA2/CAV1/SGCE/HLA-DRA/HLA-DPA1	1.944878150817
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	39/1820	154/9376	1.30463821892393	PLCB1/PIK3R5/ACTB/CAMK1D/MAP2K1/ITPR1/CAMK1/SRC/ADCY3/MYL6/PPP1CA/CAMK2D/PRKCB/PRKAG2/KRAS/CD38/GNAQ/RGS2/RHOA/CAMKK2/PTGS2/MAPK1/PPP3CC/ACTG1/MAP2K5/PPP3CB/RAF1/GUCY1A1/ADCY9/PPP1CB/MYL9/CAMK4/NFATC3/CACNA1D/PLA2G4A/PPP1R12B/PIK3CG/ELK1/PIK3R6	1.87071464708485
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	13/1820	41/9376	1.63344947735192	THBS1/MAP2K1/SRC/KRAS/BRAF/MAPK1/CXCL8/DAPK1/RAF1/RPS6KA5/UPK3A/ARAF/TYMP	1.99490448597617
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	15/1820	50/9376	1.54549450549451	IL1B/THBS1/TLR2/MYD88/CXCL8/KLRB1/PECAM1/HGF/SDC2/TGFB1/VCAM1/IL10/MET/IFNG/IL6	1.89802983452786
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1820	67/9376	1.46091520419879	PLCB1/MAP2K1/ITPR1/RAP1B/PPP1CA/RAP1A/CAMK2D/PRKCB/RPS6KA3/KRAS/BRAF/GNAQ/MAPK1/PPP3CC/PPP3CB/RAF1/PPP1CB/CAMK4/ARAF	1.85815645418901
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1820	80/9376	1.4167032967033	NRG1/RPS6/MAP2K1/SRC/PRKCB/KRAS/EIF4E2/BRAF/MAPK1/PIK3CB/IGF1R/HGF/BCL2/RAF1/SOS2/PTEN/ARAF/IL6R/PDGFRA/AXL/MET/IL6	1.83695801322179
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	42/1820	170/9376	1.27276018099548	ACTB/TIAM1/ACTR3/CD1D/ARPC3/TUBA4A/SRC/MYL6/MAPK8/MSN/MYL12A/RAP1A/YBX3/ARPC2/PRKCE/MYL12B/PRKAG2/MAP3K5/RHOA/WAS/HCLS1/RAB8A/ACTN1/RAB8B/RAPGEF2/ARPC4/ACTG1/RAC1/ARPC1A/ARHGEF18/MAPK10/CD1C/PPP2R2A/MYL9/RAP2C/CACNA1D/NEDD4L/EZR/PRKCI/PATJ/PPP2R2B/PARD6A	1.7613485367512
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1820	34/9376	1.66670976082741	NFIL3/PRKAG2/CRY1/RBX1/CUL1/CREB1/FBXW11/RORA/NR1D1/RORB/BTRC	1.91131249068535
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	30/1820	116/9376	1.33232284956423	CXCR4/ACTB/RAC2/CYBA/RAP1B/ITGA4/RASSF5/CTNNB1/MSN/RHOH/MYL12A/RAP1A/MYL12B/PTK2B/PRKCB/VCL/NCF2/CXCL12/RHOA/ACTN1/PECAM1/ACTG1/RAC1/PIK3CB/ITK/MYL9/VCAM1/EZR/MAPK14/THY1	1.76749853290025
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	19/1820	68/9376	1.43943115707822	BCL2A1/MAP2K1/RARA/NFKB1/KRAS/BRAF/DUSP6/MAPK1/TCF7L2/PIK3CB/RAF1/ZBTB16/SOS2/ARAF/STAT5B/MPO/LEF1/FLT3/PIM2	1.78481198331906
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/1820	60/9376	1.4596336996337	PLCB1/MAP2K1/ITPR1/LYN/PRKCB/GNA12/KRAS/BRAF/GNAQ/MAPK1/GNA13/IGF1R/RAF1/GUCY1A1/ARAF/PRKG1/PLA2G4A	1.75286353242391
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	25/1820	95/9376	1.3556969346443	TNFSF13B/IL1B/IL15/HLA-DQA2/TLR2/CXCL2/CD86/HLA-DRB5/ATP6V1G1/CXCL12/CXCL8/CD80/ATP6V0E1/IL1A/TGFB1/ATP6V0D1/ATP6V0B/CSF1/ATP6V1B2/CXCL3/ATP6V1H/HLA-DRA/HLA-DPA1/IFNG/IL6	1.71009365799126
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	21/1820	78/9376	1.38698224852071	BTG1/LSM6/ZCCHC7/PAN3/LSM5/CNOT2/LSM7/PABPC1/C1D/XRN2/CNOT7/LSM1/MPHOSPH6/CNOT6L/TENT4B/EXOSC5/EXOSC7/DCPS/DCP1A/CNOT9/CNOT10	1.68429799514763
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1820	110/9376	1.31132867132867	TIMP1/RPS6/ELOB/MAP2K1/HIF1A/IFNGR1/NFKB1/CAMK2D/HK2/PRKCB/RBX1/EIF4E2/MAPK1/HK1/ELOC/GAPDH/PIK3CB/CUL2/IGF1R/BCL2/PFKFB3/VHL/PGK1/IL6R/CDKN1B/EDN1/IFNG/IL6	1.6119244039939
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	9/1820	28/9376	1.65588697017268	ELOVL5/HACD4/PPT1/ACAA2/HADHA/HADHB/ELOVL7/ACOT7/HACD1	1.70578395369962
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	24/1820	93/9376	1.32945763913506	PLCB1/MAP2K1/ITPR1/SRC/ADCY3/MAPK8/MAP3K2/PTK2B/CAMK2D/PRKCB/KRAS/MAP2K3/GNAQ/MAPK1/MAP2K4/MAPK10/RAF1/ADCY9/SOS2/CACNA1D/MAP2K6/MAPK14/PLA2G4A/ELK1	1.567011698162
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	19/1820	71/9376	1.37861012227209	MAP2K1/HIF1A/SCO2/HK2/KRAS/SLC7A5/MAPK1/HK1/PGAM1/G6PD/PIK3CB/RAF1/PTEN/PDGFRA/NTRK3/SIRT3/GLS/MET/FLT3	1.57158749313035
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	36/1820	149/9376	1.24469356147208	FYN/GAB2/PLCB1/PIK3R5/MAP2K1/LPAR1/ADCY3/PTK2B/GNA12/KRAS/RHEB/RHOA/RALA/MAPK1/RRAS/CXCL8/GNA13/PIK3CB/RAF1/FCER1A/AGPAT3/DNM3/ADCY9/SOS2/AGPAT4/PLA2G4A/PDGFRA/PIK3CG/PLPP1/PIP5K1B/ARF6/SPHK1/CYTH1/CXCR2/PIK3R6/DGKA	1.47761323879448
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	34/1820	140/9376	1.25111459968603	PLCB1/PIK3R5/RPS6/MAP2K1/ITPR1/MAP1LC3B/SMAD3/GNG5/ADCY3/PRKCE/PRKAG2/KRAS/SLC8A1/GNAQ/MAPK1/RRAS/GNB1/GNGT2/HDAC4/NRF1/GNA13/MEF2D/RAF1/SMAD2/ADCY9/TGFBR1/CAMK4/GNG11/PIK3CG/SPHK1/MAP1LC3B2/PIK3R6/SLC9A1/PDE3B	1.46916095014465
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	25/1820	99/9376	1.3009213009213	GPCPD1/RAC2/MAP2K1/HIF1A/MAPK8/CHPT1/SLC22A4/PRKCB/KRAS/RHEB/SLC44A1/WAS/MAPK1/RAC1/PIK3CB/MAPK10/RAF1/SOS2/PLA2G4A/PDGFRA/PLPP1/PIP5K1B/WASF2/DGKA/SLC22A5	1.47720955195417
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1820	21/9376	1.71721611721612	VNN2/DPYD/ALDH2/PPCDC/PPCS/UPB1/ENPP1	1.61477921049852
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	26/1820	104/9376	1.28791208791209	GPAT3/GPCPD1/PLA2G6/PLD4/SGMS2/CHPT1/TAFAZZIN/GPD2/PGS1/LPIN1/PTDSS1/SAMD8/LPGAT1/GDPD5/MBOAT2/PEMT/AGPAT3/AGPAT4/LPCAT2/PLA1A/LPIN2/PLA2G4A/PLPP1/PISD/DGKA/GPAT4	1.44898942105853
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	20/1820	77/9376	1.33809048094762	RAC2/MAP2K1/SMAD3/MAPK8/NFKB1/KRAS/BRAF/RALA/MAPK1/CASP9/STAT1/RAC1/PIK3CB/MAPK10/CDK6/RAF1/SMAD2/TGFB1/TGFBR1/ARAF	1.46196016585622
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	20/1820	77/9376	1.33809048094762	GAB2/MAP2K1/SMAD3/NFKB1/KRAS/BRAF/MAPK1/CBL/CTBP2/PIK3CB/HDAC1/CDK6/RAF1/TGFB1/SOS2/TGFBR1/ARAF/MECOM/CDKN1B/STAT5B	1.46196016585622
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	22/1820	86/9376	1.31786353181702	NRG1/PAK1/MAP2K1/SRC/MAPK8/EREG/CAMK2D/PRKCB/KRAS/BRAF/MAPK1/CBL/PIK3CB/MAP2K4/MAPK10/RAF1/SOS2/AREG/ARAF/CDKN1B/STAT5B/ELK1	1.45330721881514
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	25/1820	100/9376	1.28791208791209	CX3CR1/CXCR4/CXCL2/IL2RG/CXCL12/TNFSF14/CXCL8/CXCL14/TNFRSF1B/CCR5/XCL2/XCL1/CCR2/CCL4L2/CSF1/IL6R/CCR7/IL18R1/IL19/CXCL3/CXCR2/IL20RB/TNFSF10/IL10/IL6	1.42054464259654
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	33/1820	137/9376	1.24090799711238	CTSH/CTSS/EIF2AK3/ACTB/IL3RA/BCL2A1/BID/MAP2K1/ERN1/ITPR1/CAPN2/TUBA4A/CTSW/MAPK8/NFKB1/GZMB/KRAS/MAP3K5/TRAF1/MAPK1/LMNB1/CASP8/CASP9/ACTG1/PIK3CB/PRF1/BCL2/FAS/MAPK10/RAF1/BIRC3/TNFSF10/PARP3	1.39403723672644
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	19/1820	73/9376	1.34083998193587	MAP2K1/RASSF5/RXRA/PRKCB/KRAS/BRAF/ALK/MAPK1/CASP9/PIK3CB/HGF/FHIT/CDK6/RAF1/SOS2/ARAF/EML4/STAT5B/MET	1.43474860371113
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/1820	38/9376	1.49126662810873	NAMPT/BST1/PNP/CD38/NT5C2/SIRT5/ENPP1/SIRT3/NT5E/NUDT13/NMNAT3	1.48921528287612
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	11/1820	38/9376	1.49126662810873	CIITA/IL2RG/ADA/PTPRC/IL7R/CD3D/CD3E/LCK/CD8A/CD8B/ICOS	1.48921528287612
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1820	138/9376	1.23191591017678	RPS6/INPP5A/FBP1/MAP2K1/PPP1CA/MAPK8/HK2/PRKAG2/RAPGEF1/KRAS/EIF4E2/RHEB/BRAF/PRKAR1B/MAPK1/CBL/PTPN1/HK1/RPTOR/PIK3CB/MAPK10/SH2B2/RAF1/SOS2/PPP1CB/FOXO1/ARAF/PRKCI/PRKAR2A/ELK1/ACACB/PDE3B/PHKA2	1.34696547904902
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/1820	30/9376	1.54549450549451	MDH2/SDHB/SUCLG1/IDH3G/IDH3B/IDH3A/SUCLG2/OGDH/PC	1.46863365795009
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/1820	18/9376	1.71721611721612	ACSL5/ACSL1/ACSL3/OXSM/ACSL4/ACACB	1.49475539682196
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/1820	39/9376	1.45302902225979	HLA-DQA2/CD86/HLA-DRB5/GZMB/PRF1/CD80/FAS/HLA-DRA/IL10/HLA-DPA1/IFNG	1.39132954227149
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1820	57/9376	1.3556969346443	ACSL5/ELOVL5/HACD4/ACAA1/ACSL1/ACAT2/PPT1/ACAA2/HADHA/ACSL3/HADHB/OXSM/ELOVL7/ACSL4/HACD1	1.3219293712106
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	66/1820	298/9376	1.14096909801608	CX3CR1/CSF3R/TNFSF13B/IL1B/IL15/CXCR4/IL3RA/CXCL2/IFNGR1/IL2RG/CSF2RA/CXCL12/OSM/IL1RL2/IL1RN/TNFSF8/TNFSF14/CXCL8/CXCL14/PRL/TNFRSF1B/CCR5/XCL2/IL7R/BMP6/XCL1/CCR2/IL17RA/FAS/IL21R/IL1R1/IL13RA1/IL1A/IL12RB1/CRLF2/IL31RA/TGFB1/TGFBR1/IL1RAP/TNFRSF8/IL16/BMP5/CCL4L2/RELL1/IL32/LEPR/CSF1/IL6R/ACVR1B/CCR7/ACVR1/IL18R1/IL19/CXCL3/CXCR2/IL20RB/TNFSF10/IL1RL1/TNFRSF9/TNFSF15/IL10/CSHL1/IFNG/CD27/IL6/IL27	1.21370270913692
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	12/1820	44/9376	1.404995004995	IL1B/HLA-DQA2/CD86/HLA-DRB5/GZMB/PRF1/CD80/FAS/IL1A/HLA-DRA/HLA-DPA1/IFNG	1.32149035463528
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	16/1820	62/9376	1.32945763913506	NUMB/MAML3/HES1/NOTCH2/ATXN1/ADAM17/PSEN1/MFNG/CTBP2/HDAC1/CIR1/NRARP/MAML2/NCOR2/TLE3/KAT2B	1.27732869164501
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	41/1820	180/9376	1.17343101343101	CD74/PILRA/IL1B/CFP/HLA-DQA2/BID/TLR2/SRC/IFNGR1/TRAF3/MYD88/PPP1CA/SRSF9/ALYREF/NFKB1/HLA-DRB5/C3/RHEB/TAB2/TNFSF14/SRSF4/CASP8/CASP9/STAT1/PIK3CB/TBK1/BCL2/FAS/SRPK1/EIF2B3/BIRC3/PPP1CB/TICAM1/IRAK4/ITGA5/C5/IKBKE/HLA-DRA/HLA-DPA1/IFNG/IL6	1.15302544305033
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/1820	59/9376	1.30974110635128	GPX1/GSTP1/GSTK1/MGST1/GSTO1/PGD/ANPEP/G6PD/GCLM/RRM1/SMS/GCLC/ODC1/GPX7/MGST3	1.17128386551025
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1820	110/9376	1.21766233766234	DCN/EMP3/THBS1/SMAD3/TGIF1/RBX1/TFDP1/RHOA/SKIL/MAPK1/CUL1/SMURF2/BMP6/HDAC1/ZFYVE16/SMAD2/TGFB1/LEMD3/SKI/TGFBR1/BMP5/ACVR1B/ACVR1/SMAD1/IFNG/ID4	1.12696088160118
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	26/1820	110/9376	1.21766233766234	MAP2K1/CDC26/ADCY3/MAPK8/RPS6KA3/KRAS/BRAF/MAPK1/ANAPC16/ANAPC15/PIK3CB/MAD2L2/IGF1R/KIF22/MAPK10/STK10/RAF1/SPDYE2/CDC27/ADCY9/ARAF/MAPK14/SPDYE1/AURKA/PDE3B/MAD2L1	1.12696088160118
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	18/1820	73/9376	1.27026945657083	APOBEC3A/CXCR4/CHMP4B/MDFIC/APOBEC3B/APOBEC3G/SERINC5/CCR5/PDCD6IP/TSG101/RAN/PSIP1/ELL2/SERINC3/TRIM5/APOBEC3F/KAT2B/MLLT3	1.13768555918336
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	21/1820	87/9376	1.24350132625995	COX7C/COX6B1/COX7A2L/COX7B/COX4I1/COX7A2/UQCRH/UQCRB/SLC9A7/UQCRFS1/COX5A/COX5B/SLC8A1/COX6A1/COX6C/ATP2A3/COX8A/CACNA1D/UQCRHL/ASPH/SLC9A1	1.11982931789372
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	78/1820	362/9376	1.11002367797948	CSF3R/PIK3R5/RPS6/IL3RA/THBS1/MAP2K1/ITGA4/TLR2/CREB5/LPAR1/PHLPP1/IL2RG/GNG5/EREG/RXRA/NFKB1/CCND3/KRAS/EIF4E2/RHEB/OSM/SGK1/LAMB3/COL6A2/MAPK1/GNB1/GNGT2/COL6A1/ITGB8/PRL/RPTOR/CASP9/CCND2/RAC1/IL7R/PIK3CB/IGF1R/COL1A1/CREB1/HGF/BCL2/C8orf44-SGK3/YWHAZ/LAMA2/ITGAV/CDK6/RAF1/EFNA5/COL6A3/VWF/SOS2/PPP2R2A/PTEN/ITGB7/PPP2R5C/COL9A2/AREG/ITGA5/CSF1/GNG11/IL6R/PDGFRA/YWHAH/PIK3CG/CDKN1B/MAGI2/PPP2R2B/PIK3R6/FLT3LG/MTCP1/PPP2R3A/ITGB4/CSHL1/MET/IL6/FLT3/LAMA4/IGF2	1.04774844473557
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/1820	106/9376	1.21501140369065	GSTP1/MAP2K1/CTNNB1/CREB5/NFKB1/KRAS/BRAF/MAPK1/ZEB1/CASP9/TCF7L2/PIK3CB/IGF1R/CREB1/BCL2/RAF1/SOS2/SPINT1/PTEN/FOXO1/ARAF/FOLR3/PDGFRA/CDKN1B/LEF1	1.092571625657
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	14/1820	55/9376	1.31132867132867	SGMS2/B4GALT5/ACER3/CERS6/CERK/SAMD8/NEU4/CERS5/ASAH1/CERS4/DEGS1/PLPP1/SPHK1/B4GALT6	1.13643491060697
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	34/1820	149/9376	1.17554391916808	NDUFB1/PLCB1/NDUFB5/ITPR1/NDUFA2/GNG5/ADCY3/MAPK8/NDUFB9/NDUFA4/NDUFA12/PRKCB/NDUFB6/NDUFA1/NDUFB3/GNAQ/NDUFAB1/NDUFB11/NDUFS7/NDUFS5/NDUFB4/PTGS2/MAPK1/GNB1/GNGT2/NDUFB10/NDUFB2/MAPK10/NDUFA5/ADCY9/ABHD6/CACNA1D/MAPK14/GNG11	1.06004431580524
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	20/1820	83/9376	1.24136104858996	L3MBTL4/JARID2/PCGF5/SFMBT2/UBE2D1/TFDP1/UBE2D2/PHF19/YAF2/HDAC1/OGT/MBD5/FOXK1/FOXK2/AEBP2/PHC2/RNF2/MBD6/SCMH1/L3MBTL3	1.08393594682729
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	13/1820	51/9376	1.31316526610644	ACTB/SEC61G/ADCY3/SEC61B/ATP6V1G1/ACTG1/KDELR1/ATP6V0E1/ADCY9/ATP6V0D1/ATP6V0B/ATP6V1B2/ATP6V1H	1.10054958107084
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1820	65/9376	1.26809805579036	GPAT3/GK/ALDH2/LPIN1/LPL/MBOAT2/DGAT2/AGPAT3/AGPAT4/LPIN2/LIPC/PNPLA2/PLPP1/MOGAT1/DGKA/GPAT4	1.06445556574022
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	36/1820	160/9376	1.15912087912088	VCAN/VSIR/JAML/HLA-DQA2/SELL/ICAM3/ITGA4/ICAM2/SPN/CD86/HLA-DRB5/CD22/CD58/ALCAM/NEGR1/PTPRC/ITGB8/PECAM1/SDC2/CADM1/NCAM1/CD80/CD226/CD2/ITGAV/CADM3/ITGB7/CD6/VCAM1/NTNG2/CD8A/HLA-DRA/CD8B/HLA-DPA1/ICOS/TIGIT	0.996302649827913
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	52/1820	238/9376	1.12557022809124	GAB2/PAK1/PLA2G6/TIAM1/RAC2/MAP2K1/RAP1B/RASSF5/GNG5/SHOC2/MAPK8/RAP1A/NFKB1/PRKCB/KRAS/RASGRP2/RHOA/RALA/MAPK1/RRAS/GNB1/GNGT2/RAC1/PIK3CB/TBK1/IGF1R/HGF/RASAL3/MAPK10/RAF1/EFNA5/KSR1/EXOC2/SOS2/RIN1/PLA1A/RALGAPA1/CSF1/GNG11/PLA2G4A/PDGFRA/RASA2/ELK1/RASGRP1/ARF6/HTR7/FLT3LG/LAT/MET/RASAL2/FLT3/IGF2	0.962997018138815
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1820	12/9376	1.71721611721612	COQ2/COQ5/COQ7/NQO1	1.22007160133772
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/1820	12/9376	1.71721611721612	ASGR1/NCAM1/SLAMF1/NPC1	1.22007160133772
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	25/1820	108/9376	1.19251119251119	EEF1A1/NUP214/SUMO2/ALYREF/THOC7/MAGOH/NXT1/NUP98/SUMO1/SEC13/KPNA3/NUP37/SRRM1/NUP54/RAN/KPNA4/PYM1/RAE1/IPO7/NMD3/SAP18/NUP88/RANBP17/NUP210L/IPO11	0.987529793430704
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/1820	75/9376	1.2363956043956	TKT/TALDO1/IDH3G/SDS/SDSL/IDH3B/GAPDH/PGAM1/RPIA/TKTL1/IDH3A/PGK1/ENO4/MAT2B/GLUL/PSPH/CTH/PC	1.00874306954679
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1820	43/9376	1.31786353181702	ACSL5/ALDH2/ACAA1/ACSL1/ACAT2/ECI2/ACAA2/HADHA/ACSL3/HADHB/ACSL4	1.02527332201381
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	17/1820	72/9376	1.21636141636142	TRAF3/AZI2/MAPK8/NFKB1/ATG5/TANK/CXCL8/CASP8/TBK1/MAPK10/ATG12/MAPK14/SIKE1/RNF125/CYLD/IKBKE/TRIM25	0.904454181015389
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/1820	44/9376	1.28791208791209	TAF4B/CCNH/GTF2A2/TAF12/TBPL1/TAF11/TAF10/GTF2H5/TAF13/TAF7/TBP	0.939451209190644
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	26/1820	115/9376	1.16472049689441	FYN/PLCB1/PIK3R5/MAP2K1/ITPR1/CREB5/GNG5/ADCY3/CAMK2D/PRKCB/KRAS/GNAQ/MAPK1/GNB1/GNGT2/PIK3CB/CREB1/BCL2/KCNQ5/ADCY9/CAMK4/CACNA1D/GNG11/PIK3CG/PIK3R6/KCNQ3	0.872254019327638
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	19/1820	82/9376	1.19367461806486	CDA/DPYD/UPP1/GSTP1/MGST1/GSTO1/NME3/DUT/HPRT1/GMPS/GUSB/UPB1/RRM1/NME7/UCKL1/TYMP/MGST3/UCK2/MPO	0.864477427598748
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	37/1820	170/9376	1.12124111182935	ACTB/GSTP1/MAP2K1/SMAD3/CTNNB1/MGST1/GSTO1/SMARCD3/PRKCB/KRAS/BRAF/WNT2B/MAPK1/ACTG1/TCF7L2/PIK3CB/IGF1R/HGF/ARID2/CDK6/RAF1/SMAD2/TXNRD1/TGFB1/SOS2/TGFBR1/PTEN/FZD1/ARAF/ELK1/MGST3/TXNRD3/NQO1/MET/LEF1/FZD2/IGF2	0.782914332052933
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1820	59/9376	1.22242503259452	MAP2K1/CTNNB1/KRAS/BRAF/MAPK1/CASP9/TCF7L2/PIK3CB/RAF1/SOS2/PTEN/ARAF/ELK1/LEF1	0.841098732526961
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1820	83/9376	1.17929299616047	ACSL5/GSTK1/ACAA1/SOD2/ACSL1/NUDT7/FAR2/ECI2/PEX16/ACSL3/HACL1/PEX2/ACSL4/PEX14/ABCD3/PEX7/DDO/NUDT13/ACOX2	0.805192572239998
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	43/1820	201/9376	1.10209392597452	H3-3B/H3-3A/CDK14/PBX3/BCL2A1/KDM6A/RARA/ETV6/RXRA/CD86/NFKB1/GZMB/RUNX2/BCL6/SUPT3H/TRAF1/JMJD1C/DUSP6/ZEB1/CXCL8/CCND2/PPARG/IGF1R/HDAC1/DOT1L/ZBTB17/BIRC3/ZBTB16/BCL11B/SPINT1/ELK4/ITGB7/FOXO1/ETV7/CEBPB/SMAD1/CDKN1B/NR4A3/MPO/MET/IL6/FLT3/MLLT3	0.718075740156699
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	34/1820	157/9376	1.11564359207671	ACTB/SMAD3/CTNNB1/PPP1CA/CCND3/WNT2B/MOB1A/CCND2/ACTG1/TCF7L2/BMP6/FBXW11/STK3/LATS2/YWHAZ/SMAD2/BIRC3/TGFB1/PPP2R2A/TGFBR1/PPP1CB/TP53BP2/BMP5/AREG/FZD1/YWHAH/PRKCI/SMAD1/BTRC/PATJ/PPP2R2B/PARD6A/LEF1/FZD2	0.717141490294118
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1820	89/9376	1.15767378688727	PLCB1/MAP2K1/ITPR1/TUBA4A/SRC/LPAR1/ADCY3/MAP3K2/PRKCB/KRAS/GNAQ/MAPK1/MAP2K5/RAF1/GUCY1A1/ADCY9/SOS2/TUBB6/PRKG1/PDGFRA	0.733486519350907
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	8/1820	32/9376	1.28791208791209	BID/MAPK8/CASP8/CASP9/BIRC6/BCL2/MAPK10/BIRC3	0.800652070062224
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	30/1820	138/9376	1.11992355470616	MAP2K1/ITPR1/CDC26/ADCY3/PPP1CA/CAMK2D/RPS6KA3/RBX1/MAPK1/CUL1/PPP3CC/ANAPC16/ANAPC15/MAD2L2/IGF1R/FBXW11/PPP3CB/YWHAZ/SPDYE2/CDC27/ADCY9/PPP1CB/PPP2R5C/MAPK14/YWHAH/SPDYE1/BTRC/AURKA/PTTG1/MAD2L1	0.696514905729921
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1820	75/9376	1.16770695970696	BID/GSTP1/ERCC1/MGST1/GSTO1/MAP3K5/REV3L/MAPK1/CASP8/CASP9/PIK3CB/BCL2/SLC31A1/FAS/BIRC3/MGST3/POLH	0.715636120864789
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	34/1820	158/9376	1.10858255668382	RPS6/TBC1D7/MAP2K1/LAMTOR4/PRKCB/ATP6V1G1/RPS6KA3/KRAS/EIF4E2/RHEB/BRAF/WNT2B/SGK1/SLC7A5/RHOA/SEC13/MAPK1/LPIN1/FNIP2/RPTOR/LAMTOR5/MAPKAP1/PIK3CB/IGF1R/RAF1/SOS2/PTEN/FZD1/LPIN2/ATP6V1B2/ATP6V1H/GRB10/FZD2/CAB39L	0.675531511703381
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1820	23/9376	1.3439082656474	ACAT2/PDSS2/PDSS1/NUS1/ZMPSTE24/HMGCR	0.810413043604739
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/1820	168/9376	1.10392464678179	CSF3R/IL15/IL3RA/STAT4/IFNGR1/IL2RG/CSF2RA/CCND3/PTPN2/PIAS1/OSM/PRL/CCND2/STAT1/IL7R/PIK3CB/BCL2/IL21R/RAF1/IL13RA1/IL12RB1/CRLF2/IL31RA/SOS2/LEPR/IL6R/PDGFRA/IL19/STAT5B/IL20RB/IL10/CSHL1/IFNG/IL6/STAM/IL27	0.667061537645334
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1820	37/9376	1.25310365310365	MAP2K1/CTNNB1/RXRA/KRAS/BRAF/MAPK1/TCF7L2/PPARG/LEF1	0.757049793585632
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	38/1820	178/9376	1.09979009754291	PLCB1/RAC2/DKK1/TBL1X/SMAD3/CTNNB1/MAPK8/CCDC88C/CTNNBIP1/CCND3/CAMK2D/PRKCB/RBX1/CACYBP/WNT2B/RHOA/CUL1/PPP3CC/FOSL1/PSEN1/CTBP2/CCND2/RAC1/TCF7L2/FBXW11/PPP3CB/INVS/MAPK10/NFATC3/TLE3/FZD1/BTRC/PRICKLE1/CELSR1/LEF1/ZNRF3/FZD2/APCDD1	0.659669041921626
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	69/1820	333/9376	1.06745866745867	THBS1/MAP2K1/ITGA4/MAML3/CTNNB1/CREB5/TRAF3/HES1/PTGER4/NFKB1/CCND3/NOTCH2/ATP6V1G1/KRAS/RHEB/WNT2B/LAMB3/PTGS2/COL6A2/MAPK1/TBPL1/COL6A1/ITGB8/PSEN1/MFNG/CASP8/CCND2/STAT1/TCF7L2/PIK3CB/TBK1/COL1A1/CREB1/HDAC1/FAS/LAMA2/ATP6V0E1/ITGAV/CDK6/RAF1/MAML2/COL6A3/VWF/SOS2/PPP2R2A/PTEN/ITGB7/ATP6V0D1/FOXO1/PPP2R5C/COL9A2/FZD1/TICAM1/ITGA5/ATP6V0B/ATP6V1B2/PRKCI/CDKN1B/ATP6V1H/PATJ/PPP2R2B/PARD6A/IKBKE/PPP2R3A/ITGB4/HES4/FZD2/TBP/LAMA4	0.615147080282128
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	33/1820	154/9376	1.10392464678179	ADSS2/EPRS1/KYNU/GCH1/KMO/IDO2/ALDH2/GPHN/NME3/AFMID/PTS/MTHFD2/PPCDC/TPK1/PPCS/MTHFD1L/COQ2/MTHFD2L/GUSB/OXSM/GCLM/PMM1/RFK/COQ5/MAT2B/COQ7/NME7/GCLC/ALAS1/IDO1/NQO1/ADSS1/NMNAT3	0.638177834726499
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1820	71/9376	1.16093483980808	MAP2K1/SRC/MAPK8/NFKB1/KRAS/MAPK1/PRL/CCND2/STAT1/PIK3CB/ESR1/MAPK10/RAF1/SOS2/MAPK14/STAT5B	0.668030690604588
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1820	184/9376	1.09192546583851	FYN/PAK1/CXCR4/RAC2/PLXNC1/SRC/SSH2/MYL12A/MYL12B/CAMK2D/ROBO1/KRAS/CXCL12/RHOA/CFL1/SEMA6B/DPYSL2/MAPK1/RRAS/PPP3CC/SEMA3C/UNC5B/RAC1/PIK3CB/ABLIM1/PPP3CB/SLIT2/RAF1/EFNA5/SEMA4D/MYL9/NFATC3/CDK5/NTNG2/EPHA4/PARD6A/MET/SLIT3/SEMA3A	0.618037889192897
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/1820	76/9376	1.15234239444766	CAMK1D/MAP2K1/CAMK1/CAMK2D/PRKCB/KRAS/BRAF/MAPK1/PIK3CB/IGF1R/CDK6/RAF1/SOS2/PTEN/CAMK4/ARAF/PDGFRA	0.654427373493663
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1820	19/9376	1.3556969346443	HPSE/GUSB/HGSNAT/ARSB/HYAL3	0.761664941139034
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1820	10/9376	1.54549450549451	BPNT2/SQOR/PAPSS2	0.847010241070258
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1820	34/9376	1.21215255332902	POLR1F/POLR1D/POLR2L/POLR2G/POLR2I/POLR1G/POLR3K/POLR1E	0.608195423155839
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	17/1820	78/9376	1.12279515356438	PLCB1/INPP5A/IPMK/MTMR3/IMPA2/INPP5K/PI4K2B/PIK3CB/PIP4K2A/INPP1/MTMR8/MTMR14/PTEN/INPP5F/PIK3CG/PIP5K1B/SYNJ2	0.53445250202806
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/1820	83/9376	1.11722494373097	IL1B/POLR1D/CASP1/POLR2L/NFKB1/PYCARD/AIM2/MEFV/NLRP3/PCBP1/CASP8/TBK1/ZDHHC1/POLR3K/ZBP1/CCL4L2/IKBKE/IL6	0.526449197652706
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1820	44/9376	1.17082917082917	CREB5/ARHGDIB/ADCY3/RAB11A/DYNC1LI1/DCTN2/CREB1/DYNLL1/ADCY9/DYNC2LI1	0.55741206374601
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/1820	233/9376	1.06128378059709	VIM/VCAN/DCN/ACTB/SNTB1/THBS1/DIAPH1/ITGA4/COL3A1/VCL/MYOM1/FHL3/NID1/PDLIM1/FMNL1/COL6A2/LMNB1/COL6A1/ITGB8/AMPD2/ACTG1/CAPZA1/FBN2/COL1A1/SDC2/LAMA2/PDLIM7/ITGAV/COL24A1/SUN2/COL6A3/CSRP1/MYL9/ITGB7/DIAPH2/PDLIM5/COL9A2/TNNT1/ITGA5/FBLN2/PDLIM4/COL5A2/TMOD2/SGCE/NEBL/ITGB4/ELN/ANK3	0.464894606026318
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1820	69/9376	1.11992355470616	PLCB1/PTGER2/ITPR1/PTGER4/GNAQ/PPP3CC/CREB1/PPP3CB/KCNMA1/GUCY1A1/CACNA1D/ACE/PDE3A/EDN1/PDE3B	0.490681336051413
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1820	30/9376	1.20205128205128	PIGP/PIGF/PIGH/MPPE1/PIGB/PIGV/PIGZ	0.543982222485407
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	21/1820	99/9376	1.09277389277389	FCGR2C/HLA-DQA2/KRT24/FPR1/KRT10/HLA-DRB5/C5AR1/C3/KRT14/KRT17/FCGR3B/FPR3/FPR2/C1S/C5/FCAR/HLA-DRA/IL10/HLA-DPA1/CAMP/CFH	0.455422996504351
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1820	35/9376	1.17751962323391	FBP1/GMDS/HK2/HK1/PFKFB3/PMM1/PFKFB4/SORD	0.516367691523051
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	51/1820	250/9376	1.05093626373626	CTSH/CTSS/SLC11A1/AP1S2/LITAF/RAB7A/ARSG/CTSW/SLC36A4/ARL8B/LAMTOR4/LAPTM5/LIPA/BLOC1S2/SUMF1/ATP6V1G1/VPS29/AP1G1/ROGDI/RPTOR/LAMTOR5/AP3S1/MCOLN2/VPS26A/PPT1/SLC17A5/WDR7/GUSB/ATP6V0E1/AP3B1/OSBPL5/VPS35/MANBA/SORT1/OSBPL1A/ASAH1/HGSNAT/ATP6V0D1/IGF2R/FUCA2/ARSB/ATP6V0B/LAMP3/AP4S1/ATP6V1B2/ATP6V1H/DMXL2/HYAL3/LAPTM4B/NPC1/GGA2	0.400619620505625
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1820	75/9376	1.09901831501832	THBS1/ZNF385A/BID/COP1/CCND3/CASP8/CASP9/CCND2/BCL2/SFN/FAS/CDK6/TP53I3/PERP/PTEN/AIFM2	0.422529172182793
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/1820	130/9376	1.06995773457312	PLCB1/MAP2K1/CREB5/SRC/GNG5/ADCY3/MAPK8/NFKB1/KRAS/COL3A1/MAPK1/GNB1/GNGT2/PIK3CB/COL1A1/CREB1/MAP2K4/MAPK10/RAF1/SMAD2/ADCY9/TGFB1/SOS2/TGFBR1/MAPK14/GNG11/EDN1	0.394190203171712
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1820	90/9376	1.08757020757021	CREB5/ADCY3/NFKB1/PRKAG2/KRAS/ATG5/EIF4E2/RHEB/SOD2/CAMKK2/RPTOR/PIK3CB/PPARG/IGF1R/CREB1/ADCY9/CAMK4/FOXO1/RB1CC1	0.409674235323046
Human Diseases	Substance dependence	hsa05032	Morphine addiction	19/1820	91/9376	1.0756188866079	PDE4B/PDE4A/GNG5/ADCY3/PDE7A/PRKCB/PDE8A/PDE4D/GNB1/GNGT2/OPRM1/GRK6/PDE7B/ADCY9/PDE2A/GNG11/GRK5/PDE3A/PDE3B	0.355742193287032
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1820	56/9376	1.10392464678179	TMEM258/STT3B/OSTC/DPM3/ALG5/DHRSX/B4GALT1/DAD1/DPM1/ALG14/ALG6/MAN2A2	0.382807089309543
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/1820	76/9376	1.08455754771544	ACSL5/OLR1/GK/RXRA/ACAA1/ACSL1/DBI/ME3/PPARG/ACSL3/LPL/PLIN2/ACSL4/SLC27A5/FABP3/ACOX2	0.363239491286156
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	25/1820	122/9376	1.05566564582958	FBP1/CREB5/PRKAG2/RHEB/CAMKK2/RAB8A/TBC1D1/RAB2A/RPTOR/PIK3CB/PPARG/IGF1R/CREB1/PFKFB3/RAB10/PPP2R2A/FOXO1/PPP2R5C/LEPR/PFKFB4/HMGCR/PPP2R2B/ACACB/PPP2R3A/CAB39L	0.303723067472644
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1820	17/9376	1.21215255332902	CA5B/GLUD1/CA13/GLUL	0.429668343610597
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	13/1820	62/9376	1.08018433179724	ADCY3/PRKAG2/KRAS/ATG5/SOD2/CRYAB/RPTOR/PIK3CB/IGF1R/HDAC1/ADCY9/FOXO1/HSPA6	0.310879868786421
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1820	27/9376	1.14481074481074	ELOVL5/HACD4/ACAA1/ELOVL7/ACOT7/HACD1	0.369807272018466
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	9/1820	42/9376	1.10392464678179	KYNU/KMO/IDO2/ALDH2/AFMID/ACAT2/KYAT3/HADHA/IDO1	0.331271948054692
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	28/1820	139/9376	1.03774211400111	PLCB1/KRT24/MAP2K1/ITPR1/RARA/CREB5/SRC/ADCY3/KRT10/KRAS/KRT14/GNAQ/KRT17/MAPK1/OPRM1/PIK3CB/CREB1/ESR1/NCOA3/BCL2/NCOA2/EBAG9/RAF1/ADCY9/SOS2/NCOA1/HSPA6/FKBP4	0.22001055063899
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	10/1820	48/9376	1.07326007326007	ALDH2/ACAA1/PCCA/HSD17B10/ACAT2/ACAA2/HADHA/HADHB/MCCC1/AUH	0.249729044887465
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	20/1820	99/9376	1.04073704073704	MAP2K1/SRC/ADCY3/MAPK8/NOTCH2/KRAS/BRAF/MAPK1/PIK3CB/IGF1R/ESR1/NCOA3/BCL2/MAPK10/RAF1/ADCY9/SOS2/ARAF/MAPK14/CDKN1B	0.199976357641896
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1820	38/9376	1.08455754771544	PRKCB/KRAS/SGK1/MAPK1/PIK3CB/SFN/NEDD4L/HSD11B2	0.256325964629725
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/1820	89/9376	1.04190640819854	CD44/THBS1/ITGA4/LAMB3/COL6A2/COL6A1/ITGB8/COL1A1/LAMA2/ITGAV/COL6A3/VWF/ITGB7/COL9A2/ITGA5/MEPE/ITGB4/LAMA4	0.194945438267578
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1820	18/9376	1.14481074481074	NEU4/MANBA/FUCA2/ENGASE	0.301801140727076
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1820	54/9376	1.04940984940985	MDH2/SDS/SDSL/KYAT3/AHCYL2/APIP/GCLM/MAT2B/SMS/GCLC/CTH	0.178702742866047
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	11/1820	54/9376	1.04940984940985	ERCC1/HES1/REV3L/RPA3/WDR48/FANCL/FANCA/FANCC/RMI2/POLH/FANCF	0.178702742866047
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/1820	54/9376	1.04940984940985	HLA-DQA2/TG/CD86/HLA-DRB5/GZMB/PRF1/CD80/FAS/HLA-DRA/IL10/HLA-DPA1	0.178702742866047
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1820	116/9376	1.02144751799924	PLCB1/ITPR1/DLGAP1/GNG5/ADCY3/PRKCB/GNAQ/MAPK1/GNB1/GNGT2/PPP3CC/HOMER1/SLC38A1/PPP3CB/SLC1A2/ADCY9/CACNA1D/GNG11/PLA2G4A/GLS/GRIK1/GLUL/HOMER2	0.114071170994475
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1820	39/9376	1.0567483798253	MTHFD2/ST20-MTHFS/AHCYL2/MTHFD1L/MTHFD2L/MAT2B/CTH/MTHFS	0.174283971771039
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	14/1820	70/9376	1.03032967032967	ACSL5/MAPK8/RXRA/NFKB1/PRKAG2/ACSL1/CAMKK2/TNFRSF1B/ACSL3/MAPK10/ACSL4/PRKCQ/LEPR/ACACB	0.1250001526074
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/1820	122/9376	1.0134390199964	PLCB1/MAP2K1/ITPR1/CREB5/ADCY3/MAPK8/PRKCB/KRAS/MAP2K3/GNAQ/MAPK1/STAT1/PIK3CB/CREB1/MAP2K4/MAPK10/RAF1/ADCY9/SOS2/CACNA1D/MAP2K6/MAPK14/STAT5B/CSHL1	0.0733260221147546
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1820	86/9376	1.0183490927677	ACTB/SNTB1/ITGA4/CTNNB1/SLC8A1/ITGB8/ACTG1/TCF7L2/LAMA2/ATP2A3/ITGAV/ITGB7/CACNA1D/ITGA5/SGCE/ITGB4/LEF1	0.0838940812919497
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	40/1820	205/9376	1.00519967837041	H4C3/CREB5/SRC/LYN/TRAF3/NFKB1/CCND3/KRAS/C3/GTF2A2/MAPKAPK2/TRAF1/RHOA/VDAC3/ACTN1/MAPK1/SND1/TBPL1/HDAC4/CASP8/CCND2/CCR5/RAC1/PIK3CB/CREB1/HDAC1/POLB/YWHAZ/HDAC9/CDK6/ATP6V0D1/GSN/YWHAH/HNRNPK/CDKN1B/RASA2/STAT5B/H4C5/TBP/KAT2B	0.0369420015555127
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	20/1820	102/9376	1.01012712777419	PLCB1/BST1/ITPR1/RAP1B/ATP2B1/ADCY3/RAP1A/PRKCB/CD38/RAB11A/GNAQ/RHOA/RAB8A/RAC1/RAB3D/KCNMA1/ATP2A3/ADCY9/SLC26A3/SLC9A1	0.0504694052856818
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1820	56/9376	1.01193092621664	SPOPL/CUL3/PTCH2/CUL1/CCND2/SMURF2/GAS1/FBXW11/BCL2/BTRC/SCUBE2	0.0439476416729988
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	20/1820	103/9376	1.00032006828123	PPP1CA/ALYREF/PABPC1/MAGOH/NXT1/RNGTT/SSU72/DAZAP1/SRRM1/PAPOLA/MSI2/SMG7/PYM1/PPP2R2A/PPP1CB/HBS1L/PPP2R5C/SAP18/PPP2R2B/PPP2R3A	0.00160297399816415
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	20/1820	103/9376	1.00032006828123	SLC36A4/SLC7A7/COL3A1/SLC8A1/COL15A1/KCNE3/COL6A2/KCNN4/COL6A1/COL1A1/COL24A1/COL6A3/COL8A2/COL9A2/COL23A1/COL14A1/COL5A2/COL7A1/ELN/COL18A1	0.00160297399816415
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	19/1820	98/9376	0.998788966135905	PLCB1/INPP5A/BPNT2/ITPR1/IPMK/PRKCB/MTMR3/IMPA2/PI4K2B/PIK3CB/PIP4K2A/INPP1/MTMR8/MTMR14/PTEN/INPP5F/PIP5K1B/SYNJ2/DGKA	-0.0059144926822582
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1820	93/9376	0.997093229351294	TRAF3/RXRA/NFKB1/TRAF1/LAMB3/PTGS2/CASP9/PIK3CB/BCL2/FHIT/LAMA2/ZBTB17/ITGAV/CDK6/BIRC3/PTEN/CDKN1B/LAMA4	-0.0138255820152017
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/1820	88/9376	0.995204795204795	ITGAX/SERPINB2/PLAUR/C7/C5AR1/SERPINA1/C3/CD55/CLU/VWF/C1S/PROC/PROCR/F5/C5/F3/CFH	-0.022180061712671
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	21/1820	109/9376	0.992519407198306	CREB5/PPP1CA/MAPK8/PRKCE/NFKB1/PRKCB/RPS6KA3/PRKAG2/PTPN1/PIK3CB/CREB1/OGT/MAPK10/PPP1CB/TRIB3/PTEN/FOXO1/PRKCQ/SLC27A5/ACACB/IL6	-0.0385527214124644
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1820	41/9376	1.00519967837041	GRHPR/SDS/SDSL/PGAM1/BPGM/ALAS1/PSPH/CTH	0.0163751997241001
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1820	41/9376	1.00519967837041	RAD51B/BABAM2/UIMC1/RPA3/ABRAXAS1/SEM1/NBN/RAD52	0.0163751997241001
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1820	20/9376	1.03032967032967	GMDS/CYB5R4/UAP1/CYB5R3	0.0666366166667816
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1820	99/9376	0.988700188700189	ACTB/SNTB1/ITGA4/PRKAG2/SLC8A1/ITGB8/ACTG1/LAMA2/ATP2A3/ITGAV/TGFB1/ITGB7/CACNA1D/ITGA5/ACE/SGCE/EDN1/ITGB4/IL6	-0.0554702812205583
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1820	31/9376	0.997093229351294	MDH2/GRHPR/AFMID/PCCA/ACAT2/GLUL	-0.00795568021262345
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1820	47/9376	0.986485854570961	ALDH2/MDH2/GRHPR/ACYP2/ACAT2/ME3/ACYP1/ACACB/PC	-0.0455822048096393
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/1820	47/9376	0.986485854570961	MAPK8/PRKCE/HK2/MAPK1/HK1/PIK3CB/MAPK10/CACNA1D/CACNA1G	-0.0455822048096393
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	43/1820	226/9376	0.980180881065837	PDE4B/PAK1/TIAM1/RAC2/PTGER2/MAP2K1/RAP1B/PDE4A/HCAR3/ATP2B1/CREB5/HCAR2/ADCY3/PPP1CA/MAPK8/RAP1A/NFKB1/CAMK2D/BRAF/PDE4D/POPDC2/RHOA/MAPK1/RRAS/FFAR2/RAC1/PIK3CB/CREB1/ATP2A3/MAPK10/RAF1/ADCY9/PPP1CB/MYL9/CAMK4/CACNA1D/ARAP3/PDE3A/EDN1/FXYD1/SLC9A1/PDE3B/ADORA2A	-0.148014197199484
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	30/1820	158/9376	0.978161079426902	SMAD3/CDC26/CDKN2D/CCNH/CCND3/RBX1/TFDP1/CUL1/STAG1/ANAPC16/CCND2/ANAPC15/MAD2L2/HDAC1/SFN/YWHAZ/ZBTB17/DBF4/CDK6/SMAD2/CDC27/STAG2/TGFB1/PPP2R5C/ORC4/YWHAH/CDKN1B/MTBP/PTTG1/MAD2L1	-0.135867854646978
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/1820	53/9376	0.972009122952519	PLCB1/ATP2B1/VDR/PRKCB/SLC8A1/RAB11A/GNAQ/ESR1/DNM3/ADCY9	-0.100288689621749
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/1820	37/9376	0.974636174636175	ADSS2/ASRGL1/GLUD1/GLS/GLUL/DDO/ADSS1	-0.0758648819199869
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	27/1820	143/9376	0.972688849611926	H3-3B/H3-3A/MACROH2A1/H2AZ1/H2AZ2/H2AJ/H2AC20/HLA-DQA2/H4C3/C7/CD86/HLA-DRB5/MACROH2A2/C3/H2AX/SNRPD1/ACTN1/FCGR3B/SNRPB/CD80/C1S/H4C5/C5/HLA-DRA/IL10/HLA-DPA1/IFNG	-0.161514661740609
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	25/1820	133/9376	0.968354953317359	PLCB1/ITPR1/CREB5/GNAL/GNG5/PPP1CA/MAPK8/CAMK2D/PRKCB/GNAQ/GNB1/GNGT2/PPP3CC/SLC18A2/CREB1/PPP3CB/MAPK10/PPP2R2A/PPP1CB/PPP2R5C/CACNA1D/MAPK14/GNG11/PPP2R2B/PPP2R3A	-0.180385008917146
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1820	32/9376	0.965934065934066	SUCLG1/PCCA/ECHDC1/HADHA/SUCLG2/ACACB	-0.0947336418775914
Human Diseases	Immune disease	hsa05310	Asthma	6/1820	32/9376	0.965934065934066	HLA-DQA2/HLA-DRB5/FCER1A/HLA-DRA/IL10/HLA-DPA1	-0.0947336418775914
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1820	75/9376	0.961641025641026	GPX1/PLCB1/TG/ITPR1/CREB5/ASGR1/ADCY3/PRKCB/GNAQ/ASGR2/CREB1/ADCY9/GPX7/DUOX1	-0.1636847251812
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	18/1820	97/9376	0.955975982780106	PLCB1/ITPR1/GNG5/ADCY3/CAMK2D/PRKCB/GNAQ/MAPK1/GNB1/GNGT2/CREB1/GUCY1A1/RPS6KA5/ADCY9/CACNA1D/PRKG1/GNG11/CACNA1G	-0.213894839625501
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1820	65/9376	0.951073541842773	PLCB1/MAP2K1/ITPR1/PRKCB/KRAS/GNAQ/MAPK1/KCNN4/PIK3CB/RAF1/CACNA1D/CACNA1G	-0.194257435190579
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/1820	156/9376	0.957678219216681	EIF3E/BID/MAP2K1/CTNNB1/TRAF3/RXRA/NFKB1/KRAS/BRAF/PIAS1/MAPK1/CASP8/CASP9/LDLR/STAT1/PIK3CB/TBK1/FAS/YWHAZ/CDK6/RAF1/SOS2/PPP2R2A/ARAF/TICAM1/YWHAH/PPP2R2B/IKBKE/IFNG	-0.261599030139707
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	18/1820	98/9376	0.946221125812963	PLCB1/CAMK1D/ITPR1/CAMK1/ATP2B1/CREB5/ADCY3/PRKCE/CAMK2D/PRKCB/GNAQ/LDLR/CREB1/ADCY9/CAMK4/CACNA1D/PDE2A/CACNA1G	-0.262647286149164
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/1820	82/9376	0.942374698472259	CD74/CTSS/HLA-DQA2/CIITA/HLA-DRB5/KLRD1/NFYC/CREB1/KLRC1/HSPA6/CD8A/HLA-DRA/CD8B/HLA-DPA1/IFNG	-0.25721373779924
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1820	93/9376	0.941699161054	LYZ/PLCB1/CST3/BST1/ITPR1/ATP2B1/ADCY3/PRKCB/CD38/GNAQ/KCNN4/KCNMA1/GUCY1A1/ADCY9/PRKG1/SLC9A1/CAMP	-0.277298462044736
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1820	28/9376	0.919937205651491	B3GNT5/ST3GAL4/ST3GAL6/B4GALT1/FUT7	-0.208221593199332
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/1820	61/9376	0.928985768330031	FTH1/MT2A/ATP2B1/VDR/SLC8A1/MT1X/SLC31A1/SLC26A3/SLC30A1/MT1F/MT1G	-0.27308273140716
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/1820	89/9376	0.926139029509816	SRC/GNG5/ADCY3/GABARAPL2/GPHN/PRKCB/GABARAPL1/GNB1/GNGT2/SLC38A1/ADCY9/CACNA1D/GNG11/PLCL1/GLS/GLUL	-0.34359564281575
Human Diseases	Substance dependence	hsa05034	Alcoholism	35/1820	191/9376	0.944019331453886	H3-3B/H3-3A/MACROH2A1/H2AZ1/H2AZ2/H2AJ/H2AC20/H4C3/MAP2K1/CREB5/GNG5/PPP1CA/MACROH2A2/KRAS/H2AX/BRAF/CAMKK2/MAPK1/GNB1/GNGT2/HDAC4/SLC18A2/CREB1/HDAC1/HDAC9/RAF1/ADORA2B/SOS2/PPP1CB/CAMK4/ARAF/GNG11/H4C5/PKIA/ADORA2A	-0.383610549121307
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1820	73/9376	0.917416829745597	MAP2K1/KRAS/BRAF/MAPK1/PIK3CB/IGF1R/HGF/CDK6/RAF1/PTEN/ARAF/PDGFRA/MET	-0.347629663455492
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1820	154/9376	0.936663336663337	PLCB1/PIK3R5/ATP2B1/CREB5/ADCY3/PPP1CA/CAMK2D/SLC8A1/GNAQ/POPDC2/MAPK1/CREM/CREB1/BCL2/ATP2A3/RPS6KA5/KCNE1/ADCY9/PPP2R2A/PPP1CB/PPP2R5C/CACNA1D/MAPK14/PIK3CG/PPP2R2B/PIK3R6/PPP2R3A/SLC9A1	-0.388936175572124
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1820	29/9376	0.888215233042819	PAK1/RASSF2/MOB1A/STK3/LATS2	-0.295883577401651
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	21/1820	117/9376	0.92465483234714	MACROH2A1/H2AZ1/H2AZ2/H2AJ/H2AC20/ACTB/SMARCD3/MACROH2A2/H2AX/MBD2/GATAD2A/ACTG1/HDAC1/ARID2/ZNHIT1/BICRAL/BCL7B/ING3/EPC1/GATAD2B/BCL7A	-0.402477540105823
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1820	101/9376	0.918115547818518	PLCB1/MAP2K1/CTNNB1/ADCY3/CAMK2D/PRKCB/KRAS/GNAQ/WNT2B/MAPK1/TCF7L2/CREB1/RAF1/ADCY9/FZD1/EDN1/LEF1/FZD2	-0.406050952140365
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	11/1820	63/9376	0.899494156637014	POLE4/ERCC1/POLR2L/CCNH/RBX1/RPA3/ERCC8/POLR2G/POLR2I/CUL4A/GTF2H5	-0.392818689995444
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1820	18/9376	0.858608058608059	ZNF143/MMADHC/MTRR	-0.294675987320366
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1820	69/9376	0.895938843764931	CREB5/PPP1CA/CAMK2D/PRKCB/PPP3CC/SLC18A2/CREB1/HDAC1/PPP3CB/PPP1CB/CAMK4/CACNA1D	-0.425778466103577
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/1820	36/9376	0.858608058608059	HK2/GYG1/MGAM/HK1/ENPP1/GBE1	-0.417136149048084
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1820	65/9376	0.871817413355875	PLCB1/ITPR1/CREB5/ADCY3/PDE8A/GNAQ/LDLR/CREB1/ADCY9/CACNA1D/CACNA1G	-0.50893568542328
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1820	13/9376	0.792561284868977	XRCC4/XRCC5	-0.36730711057821
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	27/1820	155/9376	0.897383906416165	PLCB1/MAP2K1/ITPR1/RAP1B/CTNNB1/CREB5/ADCY3/RAP1A/CAMK2D/PDE8A/BRAF/AHR/GNAQ/WNT2B/MAPK1/AIP/LDLR/TCF7L2/CREB1/CDK6/ADCY9/CACNA1D/FZD1/CDKN1B/LEF1/CACNA1G/FZD2	-0.632219189161082
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1820	32/9376	0.804945054945055	HK2/MGAM/B4GALT1/HK1/GALM	-0.542426497847499
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1820	20/9376	0.772747252747253	LIPA/SOAT1/EBP	-0.499291750967044
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1820	44/9376	0.819580419580419	TMEM258/STT3B/OSTC/B4GALT1/DAD1/ALG14/MAN2A2	-0.588705372587891
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1820	254/9376	0.912693605606991	PLCB1/CXCR4/PPIF/CAMK1D/ITPR1/CAMK1/ATP2B1/GNAL/ADCY3/VDAC2/PTK2B/SLC25A5/CAMK2D/CYSLTR2/P2RX1/PRKCB/SLC8A1/CD38/GNAQ/SLC25A6/ORAI2/VDAC3/MCU/PPP3CC/MCOLN2/STIM1/HGF/VDAC1/PPP3CB/ATP2A3/STIM2/ADORA2B/ADCY9/CAMK4/NFATC3/CACNA1D/PDGFRA/NTRK3/SPHK1/HTR7/ASPH/MET/CACNA1G/PHKA2/ADORA2A	-0.692298251732722
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1820	14/9376	0.735949764521193	CHST2/B4GALT1	-0.485223265364328
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1820	51/9376	0.808101702219349	PLA2G6/PLD4/PEDS1/CHPT1/PAFAH1B1/LPCAT2/PLA2G4A/PLPP1	-0.67438382888516
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1820	86/9376	0.838640429338104	PLCB1/CREB5/ADCY3/CAMK2D/KCNMB4/PRKCB/GNAQ/KCNN4/KCNMB1/CREB1/KCNMA1/ADCY9/CACNA1D/RAB3A	-0.737753801221964
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	19/1820	115/9376	0.851141901576684	PLCB1/MAP2K1/ITPR1/GNG5/PRKCB/KRAS/BRAF/GNAQ/PTGS2/MAPK1/GNB1/GNGT2/SLC18A2/RAF1/CACNA1D/ARAF/GNG11/PLA2G4A/HTR7	-0.788256938919014
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1820	15/9376	0.686886446886447	TPK1/THTPA	-0.595609657403243
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1820	28/9376	0.735949764521193	GCH1/GPHN/PTS/PCBD2	-0.686722979924071
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1820	28/9376	0.735949764521193	ATP6V1G1/ATP6V0E1/ATP6V0D1/ATP6V1B2	-0.686722979924071
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1820	76/9376	0.813418160786582	PLCB1/ACTB/ITPR1/ADCY3/CAMK2D/PRKCB/GNAQ/ACTG1/KCNJ15/ADCY9/EZR/SLC9A1	-0.801512037543871
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1820	22/9376	0.702497502497502	ALDH2/HAL/AMDHD1	-0.685612348667759
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1820	105/9376	0.834076399790686	ACTB/SNTB1/ITGA4/ADCY3/SLC8A1/ITGB8/ACTG1/LAMA2/ATP2A3/ITGAV/ADCY9/TGFB1/ITGB7/CACNA1D/ITGA5/SGCE/ITGB4	-0.839102237256791
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1820	48/9376	0.751282051282051	CHMP4B/CHMP1B/CD9/SLC10A1/LDLR/PDCD6IP/TSG101	-0.847830107392946
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1820	48/9376	0.751282051282051	PLCB1/HK2/PRKCB/MGAM/HK1/PIK3CB/CACNA1D	-0.847830107392946
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1820	23/9376	0.671954132823698	GLUD1/GLS/GLUL	-0.773033614530444
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1820	23/9376	0.671954132823698	ANPEP/PREP/ACE	-0.773033614530444
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1820	107/9376	0.818486186710486	SIK1/PLCB1/FBP1/ITPR1/CREB5/CAMK2D/PRKAG2/GNAQ/PPP3CC/PGAM1/CREB1/PPP3CB/FOXO1/PPP4R3A/ACACB/PDE3B/PHKA2	-0.926745500170281
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1820	30/9376	0.686886446886447	IL1B/NFKB1/FOLR3/IL6	-0.842994930711612
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1820	67/9376	0.768902739051993	FBP1/ALDH2/HK2/HK1/GAPDH/PGAM1/PGK1/ENO4/GALM/BPGM	-0.931656979557437
Genetic Information Processing	Transcription	hsa03040	Spliceosome	41/1820	243/9376	0.869208158097047	U2AF1/LSM6/CTNNBL1/LSM5/SRSF9/SF3B5/ALYREF/THOC7/SNRPE/LSM7/SNRPF/MAGOH/SNRPB2/SF3B6/SYF2/CDC40/SNRPD2/RBMX2/SNRPG/SNRNP40/SNRPD1/PQBP1/PCBP1/SRSF4/PPIH/SNRPA/SLU7/HNRNPC/WBP11/PHF5A/SNRPB/HNRNPA1/SMNDC1/SF3B4/BCAS2/U2AF1L4/HSPA6/SF3A2/HNRNPK/PRPF3/PRPF40B	-1.01380031401004
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1820	79/9376	0.782528863541522	ATP6V1G1/SLC18A2/STX3/ATP6V0E1/SLC1A2/DNM3/ATP6V0D1/ATP6V0B/ATP6V1B2/ATP6V1H/RAB3A/STX1B	-0.952618720266992
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1820	17/9376	0.606076276664512	SLC27A5/ACOX2	-0.797805876283662
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1820	37/9376	0.696168696168696	GMDS/HK2/HK1/UAP1/PMM1	-0.908779557425605
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1820	31/9376	0.664728819567529	DPYD/ALDH2/HADHA/UPB1	-0.917619798182822
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1820	150/9376	0.824263736263736	MAP2K1/SMAD3/CTNNB1/RXRA/KRAS/BRAF/WNT2B/MAPK1/TCF7L2/PIK3CB/HGF/BCL2/RAF1/SMAD2/TGFB1/SOS2/TGFBR1/FZD1/ARAF/CDKN1B/ABCB1/MET/LEF1/FZD2	-1.06481865409193
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	6/1820	44/9376	0.702497502497502	POLE4/ADPRS/APEX1/MPG/POLB/PARP3	-0.970744518032525
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1820	63/9376	0.735949764521193	ALDH2/CAMKMT/SMYD3/ACAT2/KMT2E/DOT1L/HADHA/MECOM/KMT2C	-1.03201827996373
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1820	52/9376	0.693491124260355	ADCY3/PTGS2/LDLR/BMP6/IGF1R/ADCY9/PLA2G4A	-1.08772460359718
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1820	26/9376	0.594420963651733	PLA2G6/ACAA1/PLA2G4A	-1.0163229323355
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1820	46/9376	0.671954132823698	FTH1/EPRS1/HCCS/GUSB/CP/ALAS1	-1.09458129488828
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1820	33/9376	0.624442224442224	IDH3G/IDH3B/IDH3A/OGDH	-1.06063489447273
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/1820	59/9376	0.698528590054014	ADCY3/PTGS2/PIK3CB/ABHD5/ADCY9/PRKG1/PNPLA2/PDE3B	-1.14001206537275
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1820	27/9376	0.572405372405372	ACAT2/HADHA/ACSM3	-1.09196042715739
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1820	49/9376	0.630814083875308	CREB5/NFKB1/SLC18A2/CREB1/CDK5/RGS9	-1.27159125993217
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1820	36/9376	0.572405372405372	B4GALT5/ST6GALNAC3/GALNT2/ST6GALNAC2	-1.26149464073091
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1820	36/9376	0.572405372405372	POLE4/RPA3/RNASEH2C/PRIM2	-1.26149464073091
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1820	148/9376	0.765785565785566	MAP2K1/CTNNB1/HES1/NOTCH2/KRAS/BRAF/WNT2B/MAPK1/TCF7L2/PIK3CB/IGF1R/ESR1/NCOA3/CDK6/RAF1/SOS2/NCOA1/PTEN/FZD1/ARAF/LEF1/FZD2	-1.40950324057063
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1820	29/9376	0.532929139825692	GNB1/GNAT2/RGS9	-1.23629185595008
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1820	50/9376	0.618197802197802	SAT1/ALDH2/SMS/ODC1/AZIN2/P4HA3	-1.32846794058896
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1820	38/9376	0.542278773857721	HK2/HK1/UAP1/PMM1	-1.3875264596988
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1820	23/9376	0.447969421882465	B4GALT1/POMK	-1.30084916724217
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1820	23/9376	0.447969421882465	GLUD1/GLS	-1.30084916724217
NA	NA	hsa04981	Folate transport and metabolism	3/1820	31/9376	0.498546614675647	ST20-MTHFS/FOLR3/MTHFS	-1.37245185716792
Cellular Processes	Cell motility	hsa04814	Motor proteins	29/1820	194/9376	0.770091763906197	ACTB/TUBA4A/DNAI2/MYL6/MYL12A/MYL12B/DYNLT1/DCTN3/DYNC1LI1/DNAH17/MYO1G/ACTR10/ACTG1/DCTN2/CAPZA1/MYO9B/KIF13B/KIF22/KIF13A/MYO1F/DYNLL1/MYL9/TUBB6/TNNT1/KIF21B/BICDL1/MYO10/DNAH14/DYNC2LI1	-1.58804245141362
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1820	15/9376	0.343443223443223	ST6GALNAC3	-1.24891290352079
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1820	24/9376	0.429304029304029	EXT1/HS3ST3B1	-1.3738317079393
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1820	144/9376	0.715506715506716	JARID2/PCGF5/MAP2K1/SMAD3/CTNNB1/KRAS/WNT2B/SKIL/MAPK1/PIK3CB/IGF1R/RAF1/SMAD2/FZD1/MAPK14/ACVR1B/ACVR1/SMAD1/FZD2/ID4	-1.6884209216757
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/1820	217/9376	0.759690079505748	MAP2K1/CREB5/SRC/MGST1/VDR/GSTO1/ADCY3/RXRA/NFKB1/CCND3/NOTCH2/PRKCB/RPS6KA3/BCL6/KRAS/AHR/MAPK1/KPNA3/AIP/PIK3CB/CREB1/ESR1/BCL2/RAF1/KPNA4/ADCY9/SOS2/CACNA1D/NR1I3/STAT5B/MGST3/IKBKE	-1.75773295309226
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1820	63/9376	0.572405372405372	PLA2G6/LTA4H/PTGR3/TBXAS1/PTGS2/PTGDS/PLA2G4A	-1.67121786993202
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/1820	63/9376	0.572405372405372	CTNNB1/WNT2B/PTCH2/TCF7L2/FZD1/LEF1/FZD2	-1.67121786993202
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1820	26/9376	0.396280642434489	CUBN/BTD	-1.51283417731141
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1820	36/9376	0.429304029304029	FGGY/GUSB/SORD	-1.68367388657232
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1820	19/9376	0.271139386928861	OGDH	-1.56073196556652
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1820	30/9376	0.343443223443223	PLA2G6/PLA2G4A	-1.76764636617629
Organismal Systems	Digestive system	hsa04976	Bile secretion	10/1820	90/9376	0.572405372405372	AQP9/ADCY3/RXRA/SLC10A1/LDLR/ADCY9/ABCB1/SLC27A5/HMGCR/SLC9A1	-2.00038925279044
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1820	70/9376	0.515164835164835	GSTP1/GSTK1/MGST1/GSTO1/PTGS2/HSD11B1/MGST3	-1.9981908453038
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1820	31/9376	0.332364409783765	ALDH2/GUSB	-1.82728391615302
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1820	49/9376	0.420542722583539	B4GALT1/MFNG/OGT/GALNT2	-1.99583130689634
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1820	23/9376	0.223984710941233	RPA3	-1.8286647199539
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1820	43/9376	0.359417326859187	ACAT2/DGAT2/PLPP1	-2.06620848123478
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1820	45/9376	0.343443223443223	ABCB7/ABCD3/ABCB1	-2.16665522217219
NA	NA	hsa04382	Cornified envelope formation	28/1820	217/9376	0.664728819567529	S100A8/S100A6/S100A12/S100A4/S100A10/KRT6A/KRT24/S100A11/S100A9/SPRR3/KRT10/KRT5/PADI2/DST/KRT14/LAMB3/KRT17/S100A16/HAL/ABHD5/PPP2R2A/PPP2R5C/S100A2/PPP2R2B/COL7A1/PPP2R3A/ITGB4/KAZN	-2.45232157231057
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1820	26/9376	0.198140321217244	HES1	-2.00934542228731
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1820	79/9376	0.456475170399221	GSTP1/GSTK1/MGST1/GSTO1/HSD11B1/CYP2S1/MGST3	-2.38087654315674
NA	NA	hsa04519	Cadherin signaling	58/1820	404/9376	0.73959308018714	VIM/CDH23/KRT6A/ACTB/KRT24/RAC2/MAP2K1/ACTR3/ARPC3/CTNNB1/SHOC2/KRT10/PPP1CA/MAPK8/KRT5/ARPC2/NFKB1/PTK2B/BRK1/KRAS/CYFIP2/VCL/MAP2K3/KRT14/WNT2B/RHOA/KRT17/ACTN1/MAPK1/RRAS/MYO1G/MOB1A/PSEN1/ARPC4/ACTG1/RAC1/TCF7L2/IGF1R/ARPC1A/STK3/LATS2/YWHAZ/MAPK10/RAF1/MYO1F/CDH11/PPP1CB/FZD1/MAPK14/ERBIN/PDGFRA/YWHAH/LHFPL5/PRICKLE1/CELSR1/MET/LEF1/FZD2	-2.62587427329484
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/1820	66/9376	0.39027639027639	DHRS9/HSD17B11/HSD11B1/SRD5A1/HSD11B2	-2.43952625755102
NA	NA	hsa04081	Hormone signaling	27/1820	219/9376	0.635134728285413	PLCB1/SRC/GNG5/ADCY3/GNA12/GNAQ/RHOA/GNB1/GNGT2/OPRM1/PRL/GNA13/PIK3CB/IGF1R/ESR1/ITGAV/ADCY9/PRKG1/LEPR/GNG11/ACVR1/SMAD1/STAT5B/VIPR1/CSHL1/THRB/IGF2	-2.68134894980001
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1820	68/9376	0.37879767291532	ALDH1A2/DHRS9/DHRS4L2/PNPLA4/CYP2S1	-2.52310137683086
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1820	73/9376	0.35285262682523	GSTP1/GSTK1/MGST1/GSTO1/MGST3	-2.72413401967765
NA	NA	hsa04082	Neuroactive ligand signaling	22/1820	199/9376	0.569528963498813	PLCB1/GNAL/P2RY13/GNG5/ADCY3/P2RX1/PRKCB/GNAQ/GNB1/GNGT2/OPRM1/SLC18A2/SLC1A2/ADORA2B/ADCY9/P2RY2/P2RY14/GNG11/GRIK1/HTR7/P2RY12/ADORA2A	-3.01228088522437
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1820	37/9376	0.139233739233739	GSTZ1	-2.57460890843684
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/1820	323/9376	0.574177525261117	VIM/CD44/THBS1/MAP2K1/PRKCE/NFKB1/SLC7A1/NOTCH2/PRKCB/KRAS/ZEB2/RHOA/PTGS2/MAPK1/PDCD4/ZEB1/RPTOR/HDAC4/CCND2/PIK3CB/HDAC1/BCL2/CDK6/RAF1/EFNA5/RPS6KA5/SOS2/PTEN/ITGA5/EZR/PDGFRA/HNRNPK/CDKN1B/ABCB1/GLS/MET	-3.82216065987515
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1820	86/9376	0.119805775619729	PLCB1/PKD2L1	-4.02434533127762
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	36/1820	370/9376	0.501241461241461	TSPO/P2RY8/UTS2/PTGER2/FPR1/S1PR4/LPAR1/P2RY13/PTGER4/C5AR1/S1PR3/GZMA/CYSLTR2/P2RX1/C3/OPRM1/PRL/CALCRL/PTGIR/ADORA2B/P2RY2/FPR3/GPR35/P2RY14/FPR2/LEPR/GRIK1/NPW/HTR7/C5/VIPR1/EDN1/CSHL1/P2RY10/THRB/ADORA2A	-4.80397337970662
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/1820	183/9376	0.309661922776677	TCOF1/NXT1/EIF6/XRN2/NOP10/NHP2/RPP25L/PWP2/RAN/NMD3/EFL1	-4.62843427443639
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1820	449/9376	0.1032624391199	GNAL/ADCY3/CAMK2D/SLC8A1/RGS2/GNB1/NCALD/PDE2A/PRKG1	-9.55676972819918