category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	125/1759	222/9376	3.00129578128441	MRPL54/MRPS15/MRPL41/MRPL52/MRPS34/MRPL33/MRPL17/MRPL43/MRPL36/MRPS21/MRPL37/MRPL51/MRPL47/RSL24D1/MRPL20/MRPL13/MRPL55/MRPS18A/RPL41/MRPL14/MRPL34/MRPS18C/MRPL40/MRPS16/MRPS23/MRPL19/MRPL21/MRPS33/MRPL27/MRPL22/RPL8/MRPL28/RPL12/MRPS7/MRPS6/MRPL12/MRPS14/MRPL3/MRPS11/MRPL15/RPL14/MRPS10/MRPL42/MRPL48/RPL35/MRPS35/MRPS9/RPL36AL/MRPL9/MRPS26/RPS12/RPS8/MRPL11/MRPL16/MRPS22/RPL10/MRPL2/RPS27L/RPS4X/MRPL4/DAP3/MRPL24/RPS27A/MRPS2/RPL35A/MRPL1/RPS15/MRPL50/RPL6/RPL26L1/RPL30/RPS14/RPL37A/RPL22/MRPL39/MRPS31/RPL13/MRPL44/RPL18/FAU/RPL5/RPL10A/RPS23/RPL21/RPL11/RPS6/RPS5/RPS3A/RPL24/MRPL49/RPL19/RPL15/RPS21/RPLP0/MRPL10/RPL3/RPS24/RPL34/RPL7/MRPS27/RPS26/RPS7/RPS13/RPLP1/RPL4/RPL9/MRPL30/UBA52/RACK1/RPL27/RPSA/RPL32/RPL36/RPL37/RPL28/MRPL53/RPL23A/RPL39/RPL38/RPS28/RPL18A/RPS15A/RPS19/RPL29/RPS3	14.5013653105582
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	127/1759	268/9376	2.5259263658965	COX7A1/KLC3/TH/TUBA4A/NDUFS4/NDUFB6/NDUFS6/NDUFC1/VDAC2/PINK1/ATP5MC1/NDUFB7/VDAC1/NDUFB10/ATP5PD/NDUFB1/PSMD8/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/PSMB6/NDUFAB1/NDUFS5/COX7A2L/COX6A1/TXN/ATP5PO/NDUFB5/TUBB6/PSMD7/PSMC5/UQCRQ/COX5A/PSMB5/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/NDUFB9/NDUFA1/PSMB7/COX7C/PSMC1/COX5B/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/UBE2L3/NDUFA2/PSMD6/PSMD4/UQCR10/CALM2/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/COX6C/SEM1/CALM1/ATP5MC3/NDUFS7/PSMD2/PARK7/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/ATP5PB/COX8A/PSMB2/ATP5F1A/TXN2/PSMD13/NDUFC2/NDUFA10/PSMC2/PSMA1/ATP5MC2/UQCR11/CYC1/SOD1/PSMA3/PSMD12/EIF2S1/NDUFA9/UQCRB/PSMA7/SLC25A4/PSMA5/NDUFS2/UQCRC2/PSMA4/ITPR3/ATP5F1B/UBE2G1/UBE2J1/PSMD1/NDUFA4L2/PSMD11/TUBA1A/RPS27A/TUBB4B/COX4I1/SLC39A6/NDUFV3/BCL2L1/SLC39A10/PSMD9/KEAP1/SLC39A9/UBA52/UQCRHL/GNAS/KLC2/CALML5	12.1791237495194
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	82/1759	138/9376	3.16728048710153	COX7A1/NDUFS4/NDUFB6/NDUFS6/NDUFC1/COX17/ATP5MC1/NDUFB7/NDUFB10/ATP5PD/NDUFB1/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/NDUFAB1/NDUFS5/COX7A2L/COX6A1/ATP5PO/NDUFB5/UQCRQ/LHPP/COX5A/ATP6V1D/NDUFB11/UQCRH/SDHC/NDUFB9/NDUFA1/COX7C/COX5B/NDUFV2/NDUFB8/NDUFA5/ATP6AP1/NDUFA8/COX6B1/PPA1/ATP5ME/NDUFA2/UQCR10/ATP5MF/SDHB/NDUFA4/ATP5F1E/ATP5F1C/COX6C/ATP5MC3/NDUFS7/COX7B/NDUFA11/ATP5F1D/ATP6V1F/UQCRFS1/ATP5PF/ATP5PB/COX8A/ATP5F1A/ATP6V1G1/PPA2/NDUFC2/NDUFA10/ATP6V1E1/ATP5MC2/UQCR11/CYC1/NDUFA9/UQCRB/NDUFS2/UQCRC2/COX11/ATP5F1B/NDUFA4L2/COX4I1/ATP6V0E1/NDUFV3/UQCRHL/ATP6V0E2	12.3251514703315
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	137/1759	308/9376	2.37094571148011	COX7A1/KLC3/POLR2I/TUBA4A/NDUFS4/NDUFB6/NDUFS6/NDUFC1/AP2S1/VDAC2/ATP5MC1/NDUFB7/VDAC1/NDUFB10/DCTN3/ATP5PD/NDUFB1/PSMD8/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/PSMB6/NDUFAB1/NDUFS5/COX7A2L/COX6A1/DCTN2/ATP5PO/NDUFB5/POLR2L/TUBB6/PSMD7/PSMC5/UQCRQ/COX5A/PSMB5/ACTR10/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/POLR2G/NDUFB9/NDUFA1/PSMB7/POLR2K/COX7C/PSMC1/COX5B/IFT57/POLR2J/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/DCTN6/PSMD6/POLR2E/PSMD4/UQCR10/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/CLTB/COX6C/SEM1/GNAQ/ATP5MC3/NDUFS7/PSMD2/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/ATP5PB/POLR2F/COX8A/PSMB2/ATP5F1A/PSMD13/NDUFC2/NDUFA10/PSMC2/CREB3/PSMA1/ATP5MC2/UQCR11/CYC1/SOD1/PSMA3/PSMD12/NDUFA9/UQCRB/PSMA7/SLC25A4/PSMA5/NDUFS2/UQCRC2/PSMA4/ATP5F1B/PSMD1/POLR2C/NDUFA4L2/PSMD11/TUBA1A/TUBB4B/COX4I1/HDAC2/CLTA/NDUFV3/HDAC1/PSMD9/ACTR1B/TBPL1/AP2A1/DNAL1/AMBRA1/DNAH5/ATG14/UQCRHL/MTOR/POLR2D/DNALI1/KLC2/TRAF2	11.7561857669686
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	149/1759	368/9376	2.15819264898534	COX7A1/KLC3/OPTN/TUBA4A/NDUFS4/NDUFB6/NDUFS6/NDUFC1/PINK1/ATP5MC1/NDUFB7/VDAC1/NDUFB10/DCTN3/ATP5PD/BAD/NDUFB1/PSMD8/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/PSMB6/NDUFAB1/NDUFS5/ACTG1/COX7A2L/COX6A1/DCTN2/ATP5PO/NDUFB5/TUBB6/PSMD7/PSMC5/UQCRQ/PFN2/COX5A/PSMB5/ACTR10/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/NDUFB9/NDUFA1/CHMP2B/PSMB7/COX7C/PSMC1/COX5B/PPP3CA/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/DCTN6/PSMD6/MAP1LC3A/PSMD4/UQCR10/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/COX6C/SEM1/ATP5MC3/NDUFS7/PSMD2/ACTB/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/ANXA7/ATP5PB/COX8A/PSMB2/ATP5F1A/PSMD13/NDUFC2/NDUFA10/PSMC2/PSMA1/ATP5MC2/UQCR11/CYC1/SOD1/SEC13/PSMA3/PSMD12/EIF2S1/ALYREF/NDUFA9/PPP3CC/UQCRB/PSMA7/WDR41/PSMA5/NDUFS2/UQCRC2/PSMA4/ANXA11/DERL1/RAC1/ITPR3/TPR/ATP5F1B/PSMD1/PPP3CB/NDUFA4L2/PSMD11/ANG/TUBA1A/TUBB4B/COX4I1/NDUFV3/BCL2L1/PSMD9/PFN1/ACTR1B/NUP54/DNAL1/AMBRA1/NXT2/NUP88/VAPB/DNAH5/ATG14/UQCRHL/NUP35/MTOR/NRG4/PFN4/HNRNPA1L3/DNALI1/NUP85/KLC2/TRAF2	10.8922375630363
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	117/1759	275/9376	2.26780091994418	COX7A1/CAV2/KLC3/CAV1/TUBA4A/NDUFS4/NDUFB6/NDUFS6/NDUFC1/VDAC2/ATP5MC1/NDUFB7/VDAC1/NDUFB10/ATP5PD/BAD/NDUFB1/PSMD8/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/PSMB6/NDUFAB1/NDUFS5/COX7A2L/COX6A1/ATP5PO/NDUFB5/TUBB6/PSMD7/PSMC5/UQCRQ/COX5A/PSMB5/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/NDUFB9/NDUFA1/PSMB7/COX7C/PSMC1/COX5B/PPP3CA/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/PSMD6/PSMD4/UQCR10/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/COX6C/SEM1/ATP5MC3/NDUFS7/PSMD2/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/ATP5PB/COX8A/PSMB2/ATP5F1A/PSMD13/NDUFC2/NDUFA10/PSMC2/CREB3/PSMA1/ATP5MC2/UQCR11/CYC1/SOD1/PSMA3/PSMD12/EIF2S1/NDUFA9/PPP3CC/UQCRB/PSMA7/SLC25A4/PSMA5/NDUFS2/UQCRC2/PSMA4/RAC1/ITPR3/ATP5F1B/PSMD1/PPP3CB/NDUFA4L2/PSMD11/TUBA1A/TUBB4B/COX4I1/NDUFV3/FYN/PSMD9/UQCRHL/KLC2	10.2541444826971
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	147/1759	388/9376	2.01946982528733	COX7A1/GAPDH/KLC3/WNT2/TUBA4A/NDUFS4/NDUFB6/NDUFS6/CAPN2/NDUFC1/VDAC2/ATP5MC1/NDUFB7/VDAC1/WNT5A/NDUFB10/ATP5PD/BAD/NDUFB1/PSMD8/COX7A2/NDUFS8/RTN3/NDUFB2/NDUFB3/UQCRC1/CAPN1/NDUFA12/NDUFB4/PSMB6/PSENEN/NDUFAB1/NDUFS5/COX7A2L/COX6A1/ATP5PO/NDUFB5/TUBB6/PSMD7/PSMC5/UQCRQ/COX5A/PSMB5/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/NDUFB9/NDUFA1/PSMB7/COX7C/PSMC1/COX5B/PPP3CA/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/PSMD6/PSMD4/UQCR10/CALM2/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/COX6C/SEM1/GNAQ/CALM1/ATP5MC3/APP/HSD17B10/NDUFS7/PSMD2/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/MAP2K2/ATP5PB/COX8A/PSMB2/ATP5F1A/PSMD13/NDUFC2/DVL1/NDUFA10/PSMC2/PSMA1/ATP5MC2/UQCR11/CYC1/NAE1/PSMA3/PSMD12/EIF2S1/NDUFA9/PPP3CC/UQCRB/PSMA7/SLC25A4/PSMA5/NDUFS2/UQCRC2/PSMA4/ITPR3/ATP5F1B/PSMD1/PPP3CB/NDUFA4L2/KRAS/PSMD11/TUBA1A/TUBB4B/COX4I1/SLC39A6/NDUFV3/PPID/SLC39A10/AKT1/WNT11/PSMD9/RTN4/FZD6/APBB1/FADD/AMBRA1/WNT7A/SLC39A9/WNT2B/BACE1/ATG14/UQCRHL/MTOR/CDK5R1/KLC2/CALML5/TRAF2/DKK2	9.85565033507086
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	164/1759	480/9376	1.82118628008338	COX7A1/KLC3/OPTN/WNT2/TUBA4A/NDUFS4/NDUFB6/NDUFS6/CAPN2/NDUFC1/VDAC2/PINK1/ATP5MC1/NDUFB7/VDAC1/WNT5A/NDUFB10/DCTN3/ATP5PD/BAD/NDUFB1/PSMD8/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/CAPN1/NDUFA12/NDUFB4/PSMB6/NDUFAB1/NDUFS5/COX7A2L/COX6A1/DCTN2/ATP5PO/NDUFB5/TUBB6/PSMD7/PSMC5/UQCRQ/COX5A/PSMB5/ACTR10/NDUFB11/UQCRH/PSMC3/SDHC/KIF5B/NDUFB9/NDUFA1/CHMP2B/PSMB7/COX7C/PSMC1/COX5B/IFT57/PPP3CA/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/UBE2L3/NDUFA2/DCTN6/PSMD6/MAP1LC3A/PSMD4/UQCR10/CALM2/SDHB/NDUFA4/ATP5F1E/ATP5F1C/PSMD14/COX6C/SEM1/GNAQ/CALM1/ATP5MC3/APP/HSD17B10/NDUFS7/PSMD2/PARK7/COX7B/PSMB1/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PSMC6/MAP2K2/ATP5PB/COX8A/PSMB2/ATP5F1A/PSMD13/NDUFC2/DVL1/NDUFA10/PSMC2/PSMA1/ATP5MC2/UQCR11/CYC1/SOD1/PSMA3/PSMD12/EIF2S1/NDUFA9/PPP3CC/UQCRB/PSMA7/WDR41/SLC25A4/PSMA5/NDUFS2/UQCRC2/PSMA4/DERL1/RAC1/ITPR3/ATP5F1B/UBE2G1/UBE2J1/PSMD1/PPP3CB/NDUFA4L2/KRAS/PSMD11/TUBA1A/RPS27A/TUBB4B/COX4I1/NDUFV3/BCL2L1/PPID/WNT11/PSMD9/FZD6/ATXN3/ACTR1B/SPTBN2/FADD/DNAL1/AMBRA1/WNT7A/VAPB/DNAH5/WNT2B/ATG14/UBA52/UQCRHL/MTOR/DNALI1/CDK5R1/KLC2/CALML5/TRAF2/ZFYVE1/DKK2	8.87547278218221
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	98/1759	235/9376	2.2228490559191	COX7A1/NDUFS4/NDUFB6/NDUFS6/NDUFC1/COX17/ATP5MC1/NDUFB7/NDUFB10/ATP5PD/NDUFB1/COX7A2/NDUFS8/NDUFB2/NDUFB3/ACSL3/UQCRC1/NDUFA12/NDUFAF8/NDUFB4/NDUFAB1/NDUFS5/ACTG1/COX7A2L/COX6A1/ATP5PO/NDUFB5/NDUFAF3/UQCRQ/COX5A/COX20/NDUFB11/UQCRH/SDHC/NDUFB9/NDUFA1/COX7C/COX5B/NDUFV2/NDUFB8/NDUFA5/COX14/NDUFA8/COX6B1/ATP5ME/NDUFA2/UQCR10/ATP5MF/SDHB/NDUFA4/ATP5F1E/ATP5F1C/COA4/COX6C/ATP5MC3/NDUFS7/ACTB/COX7B/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/COA3/ATP5PB/COA6/COX8A/NDUFAF2/ATP5F1A/NDUFC2/NDUFA10/CREB3/ATP5MC2/UQCR11/CYC1/NDUFA9/ACTL6A/UQCRB/COA1/NDUFS2/UQCRC2/COA5/COX11/ATP5F1B/NDUFA4L2/KRAS/COX4I1/NDUFAF4/MLST8/NDUFV3/AKT1S1/RPS6/NDUFAF1/NDUFAF6/NDUFAF5/UQCRHL/RPS6KA2/MTOR/GNAS	9.1229755176388
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	85/1759	205/9376	2.21012493240339	COX7A1/GAPDH/NDUFS4/NDUFB6/NDUFS6/MPC2/NDUFC1/VDAC2/ATP5MC1/NDUFB7/VDAC1/NDUFB10/ATP5PD/NDUFB1/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/PPP1CB/NDUFA12/NDUFB4/NDUFAB1/NDUFS5/COX7A2L/COX6A1/ATP5PO/NDUFB5/UQCRQ/COX5A/NDUFB11/UQCRH/SDHC/NDUFB9/NDUFA1/COX7C/COX5B/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/UQCR10/SDHB/NDUFA4/ATP5F1E/ATP5F1C/COX6C/ATP5MC3/NDUFS7/COX7B/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/PPP1CA/MPC1/ATP5PB/COX8A/SLC2A1/ATP5F1A/NDUFC2/NDUFA10/ATP5MC2/UQCR11/CYC1/NDUFA9/UQCRB/SLC25A4/NDUFS2/UQCRC2/RAC1/PDHB/ATP5F1B/PRKCZ/NDUFA4L2/COX4I1/SMAD2/NDUFV3/PDK2/AKT1/UQCRHL/MTOR/PPARA	8.41831888612546
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	91/1759	227/9376	2.13681682373595	COX7A1/NDUFS4/NDUFB6/GSTO2/NDUFS6/NDUFC1/VDAC2/ATP5MC1/NDUFB7/VDAC1/NDUFB10/ATP5PD/BAD/NDUFB1/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/ACP1/NDUFA12/NDUFB4/NDUFAB1/NDUFS5/COX7A2L/COX6A1/ATP5PO/NDUFB5/UQCRQ/COX5A/NDUFB11/UQCRH/SDHC/NDUFB9/NDUFA1/COX7C/COX5B/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/UQCR10/SDHB/NDUFA4/ATP5F1E/ATP5F1C/COX6C/ATP5MC3/NDUFS7/COX7B/NDUFA11/ATP5F1D/UQCRFS1/ATP5PF/MAP2K2/ATP5PB/COX8A/ATP5F1A/NDUFC2/NDUFA10/MGST2/ATP5MC2/UQCR11/CYC1/SOD1/MET/NDUFA9/UQCRB/SLC25A4/NDUFS2/MGST3/UQCRC2/RAC1/GSTO1/ATP5F1B/NDUFA4L2/KRAS/SLC26A2/COX4I1/NQO1/NDUFV3/AKT1/MAP2K4/MGST1/PTPN11/KEAP1/GSTA4/UQCRHL/SRC	8.33188346529604
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	30/1759	46/9376	3.4762834614529	PSMD8/PSMB6/PSMD7/PSMC5/PSMB5/PSMC3/PSMB7/PSMC1/PSMD6/PSMF1/PSMD4/PSMD14/SEM1/PSMD2/PSMB1/PSMC6/PSMB2/PSMD13/PSMC2/PSMA1/PSMA3/PSMD12/PSMA7/PSMA5/PSMA4/PSMD1/PSMD11/PSMD9/POMP/PSME3	8.09030754516252
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	63/1759	157/9376	2.13891071577293	COX7A1/NDUFS4/NDUFB6/NDUFS6/NDUFC1/NDUFB7/ADIPOR1/NDUFB10/NDUFB1/COX7A2/NDUFS8/NDUFB2/NDUFB3/UQCRC1/NDUFA12/NDUFB4/NDUFAB1/NDUFS5/COX7A2L/COX6A1/NDUFB5/UQCRQ/COX5A/NDUFB11/UQCRH/SDHC/NDUFB9/NDUFA1/COX7C/COX5B/NDUFV2/NDUFB8/NDUFA5/NDUFA8/COX6B1/NDUFA2/UQCR10/SDHB/NDUFA4/COX6C/NDUFS7/COX7B/NDUFA11/UQCRFS1/COX8A/NDUFC2/NDUFA10/UQCR11/CYC1/EIF2S1/NDUFA9/UQCRB/NDUFS2/UQCRC2/RAC1/NDUFA4L2/COX4I1/NDUFV3/AKT1/LEPR/UQCRHL/PPARA/TRAF2	6.91550943224628
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	21/1759	31/9376	3.61084927286398	SEC11C/SRP14/SRP9/SPCS1/SPCS2/TMEM208/SEC61G/SEC62/GET3/SRP72/IMMP2L/SPCS3/SEC11A/SEC61B/SRP19/SRP68/SEC63/UBL4A/IMMP1L/SRPRB/SGTA	6.99680184387366
NA	NA	hsa04382	Cornified envelope formation	72/1759	217/9376	1.76857923568848	KRT6A/SPRR3/KRT5/KRT14/KRT17/KRT24/S100A6/S100A10/S100A14/DSG1/S100A16/S100A4/KRT19/EVPL/PPL/S100A11/KRT16/JUP/LAMB3/DST/ITGA6/PKP3/ITGB4/CAPN1/KRT8/PLEC/TMEM79/KRT10/S100A13/KDSR/KRT18/DSP/DSG2/PKP1/COL7A1/ELOVL1/S100A3/S100A2/COL17A1/PPP2CB/PPP2R1A/PPP2R2A/LAMC2/KRT13/COL4A5/CLDN3/CLDN4/KRT15/PPP2R3A/SPTLC3/KRT6C/KRT27/SPRR1A/SPRR1B/KRT6B/PPP2R2B/CLDN9/KRT78/SLC27A4/COL4A6/DSG3/CLDN1/KRT72/OCLN/PPP2R5B/PPP2R1B/S100A5/DSC1/KRT80/CDSN/CASP14/KRT9	5.50454041511148
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	28/1759	63/9376	2.3690228033605	POLR2I/CETN2/ERCC6/GTF2H5/POLR2L/POLD2/RBX1/POLR2G/RPA3/POLR2K/POLR2J/POLR2E/POLR2F/RAD23B/XPA/RAD23A/RFC1/MNAT1/ERCC1/POLE4/POLE3/POLR2C/RFC2/POLD3/ERCC4/GTF2H3/RFC5/POLR2D	5.23917295390245
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	42/1759	116/9376	1.92993668032385	GAPDH/TPI1/PFKP/ENO1/PGAM1/PKM/ESD/TALDO1/PGLS/ECHS1/PGK1/SUCLA2/SUCLG1/SDHC/MDH2/MDH1/GLUD1/SDHB/PGP/ACAT2/ALDOA/IDH3A/IDH3G/PDHB/ACOX1/DLD/FH/SUCLG2/ALDOC/HIBCH/MCEE/MMUT/DLST/PRPS2/GOT1/RPE/ACO1/IDNK/PSPH/PCCB/ENO2/PGAM4	4.84287723193043
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	75/1759	250/9376	1.59909039226833	CAV2/CAV1/ARF5/AP2S1/ASAP2/SH3GLB2/CHMP2A/WASHC3/RAB22A/CAPZA2/SNF8/KIF5B/TSG101/CHMP2B/VPS29/EHD2/CHMP4C/ARF6/RAB10/CHMP3/RAB11A/CLTB/RAB4A/SMAP1/SH3GLB1/VTA1/ARPC5L/RAB11FIP1/CHMP5/VPS35/STAMBP/ARPC4/ARPC1A/CHMP4B/SNX12/VPS26A/VPS4A/VPS25/ARF1/ASAP1/FOLR3/PRKCZ/WASL/RHOA/STAM/VPS4B/SPG21/ARF4/CLTA/SMAD2/ACAP2/RAB5B/MVB12A/NEDD4L/SNX3/EPN2/AGAP1/CHMP6/EPN3/PARD6B/CBLC/RABEP1/AP2A1/ARPC3/RAB11FIP5/SMURF1/CHMP7/NEDD4/PRKCI/SRC/PIP5KL1/GRK4/TRAF6/IQSEC2/RAB11FIP2	4.61369315186672
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	33/1759	85/9376	2.06941109587667	GUK1/NME3/NT5C/APRT/ADSS2/DUT/CMPK1/NME1/DGUOK/AK2/HDDC2/NT5E/DCTPP1/ADK/AK3/DCTD/GMPS/ITPA/ENPP1/RRM1/NME4/NT5C3B/DTYMK/NTPCR/AK4/UCK1/NME6/NT5C3A/NME7/AK9/ASMTL/ENTPD5/NT5DC4	4.75937032962697
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	16/1759	30/9376	2.84282736403259	PIGP/PIGT/GPAA1/PIGC/DPM2/PIGK/PGAP2/PIGX/PIGF/PIGV/PGAP4/PIGH/PGAP3/PIGU/PIGL/PIGM	4.85801634405085
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	17/1759	34/9376	2.66515065378056	POLR2I/POLR2L/POLR2G/POLR2K/POLR2J/POLR2E/POLR2F/POLR2C/POLR1F/POLR1C/POLR3K/POLR3H/POLR3D/POLR3F/POLR2D/POLR3C/POLR3G	4.67411764770705
Cellular Processes	Cell motility	hsa04814	Motor proteins	59/1759	194/9376	1.62107101621704	KLC3/MYH14/TUBA4A/DYNLL1/DYNLT1/KIF1C/DCTN3/ACTG1/DYNLT3/MYL12B/DCTN2/TUBB6/CAPZA2/ACTR10/KIF9/KIF5B/MYO6/KIF13A/DYNC1LI2/DCTN6/DYNC1I2/ACTB/TNNT1/KIFAP3/MYO1C/MYO5B/MYL6B/TUBG1/TUBA1A/TUBB4B/TPM4/MYL12A/TPM3/MYO1E/KIF22/DYNC2LI1/MYL5/MYO1D/ACTR1B/MYL6/MYO9A/KIF3A/DNAL1/KIF3B/DNAI4/TNNC2/MYO18A/DNAH5/TUBD1/MYL11/DYNLRB2/TUBG2/MYO3B/DNALI1/KLC2/BICDL2/KIF27/DYNC2H1/BICDL1	4.20049104520056
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	46/1759	142/9376	1.72671732498459	FBXO2/ANAPC16/UBE2M/STUB1/ANAPC11/RNF7/UBE2B/CDC26/UBE2E3/ELOB/RBX1/ANAPC13/UBE2L3/UBE2D2/UBE2E2/ELOC/UBE2I/CDC34/ANAPC5/UBE2N/ANAPC15/UBE2E1/UBE2Q1/UBE2G1/UBE2J1/CUL5/RPS27A/CDC16/UBE2Q2/NEDD4L/CDC27/CBLC/CUL3/UBE2D4/KEAP1/FBXW11/PIAS3/RHOBTB2/UBA52/SMURF1/FZR1/BTRC/FBXO4/NEDD4/NHLRC1/TRAF6	4.19315900436226
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	71/1759	248/9376	1.52601368079371	S100A10/ANXA2/AHNAK2/GAPDH/KLC3/RRAS/TUBA4A/DYNLL1/DYNLT1/DCTN3/AHNAK/BRK1/ACTG1/DYNLT3/MYL12B/TXN/DCTN2/TUBB6/PFN2/RAB9A/ACTR10/KIF5B/MYO6/NCKAP1/RALA/ARF6/DYNC1LI2/DCTN6/DYNC1I2/ACTB/ARPC5L/MAP2K2/TXN2/ACBD3/ARPC4/ARPC1A/TRADD/ARF1/KPNA4/RAC1/WASL/TUBA1A/RHOA/TUBB4B/EXOC5/CSE1L/RAB5B/MYL12A/FBXO22/VPS41/STX10/AKT1/MAP2K4/EXOC7/PFN1/DYNC2LI1/MYL5/ACTR1B/KPNA3/FADD/IRAK4/ARPC3/SNX33/MYL11/DYNLRB2/PFN4/KLC2/TRAF2/TRAF6/DYNC2H1/RPS3	4.03423919469845
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	14/1759	27/9376	2.76385993725391	HACD4/HACD2/SCP2/TECR/ELOVL1/ACAA1/HACD3/HSD17B12/ACOX1/ACOT7/SCD5/ELOVL6/HACD1/ACOT4	4.41052185551067
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	53/1759	174/9376	1.62359752471689	FBXO2/BAG1/CAPN2/CRYAB/STUB1/OSTC/CAPN1/DAD1/SEC61G/UFD1/SELENOS/RBX1/NSFL1C/SEC62/SAR1B/DNAJB2/UBE2D2/UBXN1/KRTCAP2/TMEM258/UBXN4/BCAP31/ERO1A/RAD23B/SSR4/RAD23A/ERLEC1/SEC13/SSR3/EIF2S1/SEC61B/DNAJC1/SEC31A/AMFR/DERL1/PDIA6/ERP29/UBE2G1/MAGT1/UBE2J1/MARCHF6/SEC63/SSR2/HSPBP1/UBXN6/SVIP/DNAJA2/ATXN3/UBE2D4/UGGT2/TRAF2/MBTPS2/HSPA4L	3.98992261389758
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	14/1759	28/9376	2.66515065378056	HACD4/HACD2/TECR/ECHS1/ELOVL1/HADHB/HADHA/HACD3/HSD17B12/ACOT7/ELOVL6/HACD1/THEM4/ACOT4	4.24033116840681
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	45/1759	144/9376	1.66571915861285	VDAC2/VDAC1/PSMD8/PSMB6/PSMD7/PSMC5/PSMB5/PSMC3/PSMB7/PSMC1/PSMD6/PSMD4/PSMD14/SEM1/GNAQ/PSMD2/PSMB1/PSMC6/PSMB2/PSMD13/PSMC2/PSMA1/PSMA3/PSMD12/PSMA7/SLC25A4/PSMA5/ATXN10/PSMA4/ITPR3/PSMD1/SLC1A6/PSMD11/AKT1/PSMD9/ATXN3/TBPL1/SPTBN2/AMBRA1/BEAN1/ATG14/OMA1/MTOR/TRAF2/VLDLR	3.86857466999907
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	23/1759	59/9376	2.07791406904925	NME3/NT5C/DUT/CMPK1/NUDT2/NME1/HDDC2/NT5E/DCTPP1/DCTD/ENPP1/RRM1/NME4/NT5C3B/DTYMK/UCK1/NME6/NT5C3A/NME7/AK9/ASMTL/ENTPD5/NT5DC4	3.99115577480269
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	66/1759	238/9376	1.47815078276905	RSL24D1/RPL41/RPL8/RPL12/IFNAR1/RPL14/RPL35/RPL36AL/RPS12/RPS8/RPL10/RPS27L/RPS4X/RPS27A/RPL35A/RPS15/RPL6/RPL26L1/RPL30/RPS14/RPL37A/RPL22/RPL13/RPL18/FAU/RPL5/RPL10A/RPS23/RPL21/RPL11/RPS6/RPS5/RPS3A/RPL24/RPL19/RPL15/RPS21/RPLP0/RPL3/RPS24/RPL34/RPL7/RPS26/RPS7/IRAK4/RPS13/RPLP1/RPL4/RPL9/UBA52/RPL27/RPSA/RPL32/RPL36/RPL37/RPL28/RPL23A/RPL39/RPL38/RPS28/RPL18A/RPS15A/RPS19/TRAF6/RPL29/RPS3	3.59049521996365
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	14/1759	30/9376	2.48747394352852	SUCLA2/SUCLG1/SDHC/MDH2/MDH1/SDHB/IDH3A/IDH3G/PDHB/DLD/FH/SUCLG2/DLST/ACO1	3.92124236379828
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	27/1759	83/9376	1.7339534373994	SCP2/PMVK/ACSL3/CROT/PRDX5/PEX2/GSTK1/ACAA1/SOD1/ACOX1/MPV17/HMGCL/PEX10/PHYH/GNPAT/PEX16/PEX7/PRDX1/SLC25A17/PEX3/MVK/PEX19/HACL1/PEX11A/PEX1/PEX11B/NUDT7	3.22742505773036
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	33/1759	108/9376	1.62870317731034	THOC7/SUMO1/UPF3A/SRRM1/RAN/UBE2I/EEF1A1/MAGOHB/PHAX/SUMO2/SUMO3/SEC13/SAP18/IPO7/ALYREF/KPNA4/TPR/CSE1L/PYM1/SENP2/KPNA3/NUP54/IPO5/THOC6/NXT2/NUP88/SNUPN/THOC3/THOC5/XPO7/NUP35/NUP85/IPO11	3.15784711774101
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	35/1759	117/9376	1.59453457918495	H2AZ1/MACROH2A1/H2AJ/CDK2AP1/H2AZ2/ACTG1/ZNHIT1/H2AC6/BCL7C/MEAF6/MBD2/BRD7/ACTB/CDK2AP2/CHD3/RUVBL2/MORF4L1/INO80C/ACTL6A/UCHL5/BCL7B/YY1/POLE3/YEATS4/HDAC2/CHRAC1/HDAC1/MTA3/RUVBL1/DMAP1/MTA1/H2AX/H2AC20/BICRAL/MACROH2A2	3.10967203420011
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	32/1759	105/9376	1.6244727794472	OPTN/BNIP3/RRAS/PINK1/FIS1/GABARAPL2/TOMM7/MAP1LC3A/FKBP8/TOMM20/TAX1BP1/MTX1/EIF2S1/MARCHF5/BNIP3L/AMFR/TBC1D17/KRAS/RPS27A/FUNDC1/MTX2/SAMM50/RRAS2/RAB5B/BCL2L1/AMBRA1/MUL1/UBA52/SMURF1/SRC/ATG9B/TRAF2	3.09222759513064
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	7/1759	12/9376	3.10934242941065	VKORC1/COQ4/COQ5/VKORC1L1/NQO1/COQ3/COQ6	3.51344847710582
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	27/1759	87/9376	1.65423144027759	COX7A1/COX7A2/UQCRC1/COX7A2L/COX6A1/UQCRQ/COX5A/UQCRH/COX7C/COX5B/COX6B1/UQCR10/COX6C/COX7B/UQCRFS1/COX8A/UQCR11/CYC1/UQCRB/ATP1A4/UQCRC2/ASPH/COX4I1/TPM4/TPM3/UQCRHL/CACNA2D3	2.94600266991414
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	16/1759	44/9376	1.93829138456768	POLD2/MPG/APEX1/RFC1/POLE4/POLE3/ADPRS/SMUG1/RFC2/HMGB1/PNKP/TDG/POLD3/UNG/RFC5/NEIL1	2.99780432579348
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	46/1759	170/9376	1.44231682439889	CCND1/MYH14/TUBA4A/YBX3/RAB13/EZR/RAP1A/ACTG1/MYL12B/LLGL2/RDX/PPP2CB/ACTB/ARPC5L/PPP2R1A/ARPC4/ARPC1A/PPP2R2A/CRB3/RAC1/AMOT/PRKCZ/MYL6B/AMOTL1/CLDN3/TUBA1A/RHOA/CLDN4/MYL12A/NEDD4L/PARD6B/MYL6/EPB41L4B/PATJ/DLG3/PPP2R2B/ARPC3/CLDN9/NEDD4/CLDN1/PRKCI/SRC/OCLN/NF2/PPP2R1B/CGN	2.79672016945017
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	19/1759	56/9376	1.80849508649395	OSTC/DAD1/DPM3/KRTCAP2/TMEM258/ALG5/ALG3/DPM1/B4GALT2/DPM2/ALG14/MAGT1/ALG8/DPAGT1/DOLK/MGAT3/ALG6/ALG1/ALG11	2.91601680404797
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	10/1759	23/9376	2.31752230763527	PMVK/FDPS/GGPS1/ACAT2/MVD/ICMT/HMGCR/MVK/RCE1/PDSS2	3.03999597204028
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/1759	57/9376	1.77676710252037	HACD4/HACD2/SCP2/ACSL3/TECR/ECHS1/ELOVL1/HADHB/HADHA/ACAA1/ACAT2/HACD3/HSD17B12/ACOX1/SCD5/ELOVL6/MCAT/OXSM/HACD1	2.82663789018502
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	24/1759	78/9376	1.6400927100188	CAV2/CAV1/ACTG1/CD2AP/SEPTIN1/CLTB/CTNNA1/ACTB/WASF2/ARPC5L/ARPC4/ARPC1A/MET/RAC1/ELMO3/WASL/RHOA/MAD2L2/CLTA/SEPTIN11/SHC3/ARPC3/CRK/SRC	2.72785946012887
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	23/1759	75/9376	1.63462573431874	GAPDH/TPI1/PFKP/BCAT1/ENO1/PGAM1/PKM/TALDO1/PGK1/ALDOA/IDH3A/IDH3G/ALDOC/PRPS2/ASNS/GOT1/RPE/ACO1/PSPH/ENO2/ALDH18A1/NAGS/PGAM4	2.65161256659605
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/1759	32/9376	1.99886299033542	ECHS1/SUCLA2/SUCLG1/HADHA/ACOX1/DLD/SUCLG2/BCKDHB/HIBCH/MCEE/MMUT/PCCB	2.71982572052055
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/1759	48/9376	1.77676710252037	BCAT1/ECHS1/HSD17B10/HADHB/HADHA/ACAA1/ACAT2/DLD/HMGCL/BCKDHB/HIBCH/MCEE/MMUT/MCCC1/AUH/PCCB	2.59264917606152
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	62/1759	253/9376	1.3062398461217	H3-3B/H3-3A/CAST/BNIP3/CAPNS1/CAPN2/VDAC1/CAPN1/ACTG1/MYL12B/PFN2/RBX1/UBE2V2/U2AF1/ARF6/MAP1LC3A/PLCD1/UBE2D2/TNIP1/ACTB/WASF2/SEPTIN7/ARPC5L/ARPC4/ARPC1A/RRAGA/UBE2N/SHARPIN/TRADD/DIAPH1/ARF1/RAC1/ITPR3/WASL/RPS27A/RHOA/RRAGC/MYL12A/FNBP1L/BCL2L1/PPID/AKT1/AKT1S1/PFN1/ATG5/MYL5/UBE2D4/SEPTIN11/FBXW11/ARPC3/CRK/ATG14/UBA52/GLMN/BTRC/MYL11/MTOR/SRC/PFN4/RRAGB/TRAF2/TRAF6	2.37290144695521
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	12/1759	33/9376	1.93829138456768	VAMP2/STX8/VTI1B/VAMP3/USE1/VAMP8/STX7/VAMP4/STX18/YKT6/STX19/STX6	2.59464594583317
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1759	157/9376	1.39198951343953	CCND1/WNT2/WNT5A/PPP1CB/ACTG1/AREG/YAP1/YWHAH/LLGL2/CCND3/YWHAQ/PPP2CB/CTNNA1/ACTB/PPP1CA/PPP2R1A/DVL1/PPP2R2A/YWHAB/AMOT/WWTR1/PRKCZ/SNAI2/SMAD2/YWHAZ/WNT11/FZD6/PARD6B/PATJ/BMPR1A/WNT7A/FBXW11/DLG3/PPP2R2B/WNT2B/BTRC/PRKCI/SMAD1/BMP2/NF2/PPP2R1B	2.38017532014611
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	23/1759	78/9376	1.57175551376802	PFKP/LSM5/ENO1/LSM4/TOB1/EXOSC7/LSM3/LSM1/XRN2/C1D/LSM6/CNOT7/CNOT2/MPHOSPH6/DCPS/ZCCHC7/EXOSC3/EXOSC5/EXOSC9/DIS3L/EXOSC2/ENO2/EDC3	2.43662935493691
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	40/1759	154/9376	1.38449384611977	PPCS/VKORC1/BCAT1/NME3/ADSS2/EPRS1/CMPK1/PTS/NME1/MMAB/AK2/COQ4/PMM1/AK3/MOCS2/UROS/UROD/DLD/COQ5/PANK2/NME4/VKORC1L1/NQO1/PPOX/AK4/PMM2/MPI/NADK2/COQ3/NME6/PPCDC/ALAD/NME7/AK9/COQ6/LIAS/OXSM/NMNAT1/LIPT1/SPR	2.3118719454742
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	34/1759	128/9376	1.41586128482092	GUK1/NME3/NT5C/APRT/ADSS2/NUDT2/NME1/DGUOK/AK2/HDDC2/NT5E/PAICS/ADK/PGM1/AK3/ATIC/GMPS/ITPA/ENPP1/RRM1/NME4/NTPCR/GUCY1A1/PAPSS1/AK4/HDDC3/PRPS2/NME6/NME7/AK9/PDE6D/PDE10A/ENTPD5/NT5DC4	2.27643967135334
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	43/1759	169/9376	1.35623051020786	OPTN/BNIP3/RRAS/BAD/GABARAPL2/MAP1LC3A/PPP2CB/SH3GLB1/MAP2K2/TAX1BP1/LAMP1/IGBP1/WDR45/RRAGA/EIF2S1/VAMP8/STX7/WDR41/GORASP2/KRAS/RPS27A/RRAGC/RRAS2/MLST8/VPS41/BCL2L1/AKT1/AKT1S1/HMGB1/ATG5/EIF2AK4/ATG10/YKT6/AMBRA1/SUPT20H/ATG14/UBA52/MTOR/RRAGB/ATG9B/ZFYVE1/TRAF6/RAB33B	2.24564950540281
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	26/1759	93/9376	1.49019176340418	LMO7/ARHGAP29/ACP1/RAP1A/ACTG1/MYL12B/BAIAP2/PDCD10/CTNNA1/ACTB/WASF2/NECTIN4/MET/RAC1/SNAI2/WASL/RHOA/MYL12A/FYN/NECTIN3/MYL5/FER/RASIP1/SMURF1/MYL11/SRC	2.28291577342008
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/1759	31/9376	1.89139723816685	PFKP/TALDO1/PGLS/PGM1/ALDOA/DERA/ALDOC/PRPS2/RBKS/RPE/IDNK	2.38885097828266
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	11/1759	31/9376	1.89139723816685	GRHPR/MDH2/MDH1/PGP/ACAT2/HYI/DLD/MCEE/MMUT/ACO1/PCCB	2.38885097828266
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	16/1759	51/9376	1.67225139060741	ACTG1/SEC61G/ATP6V1D/KDELR1/ATP6AP1/ACTB/ATP6V1F/ERO1A/ATP6V1G1/ATP6V1E1/SEC61B/ARF1/ATP6V0E1/KDELR3/GNAS/ATP6V0E2	2.31323075224912
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	38/1759	149/9376	1.35940570259948	NDUFS4/NDUFB6/NDUFS6/NDUFC1/NDUFB7/NDUFB10/NDUFB1/NDUFS8/NDUFB2/NDUFB3/NDUFA12/NDUFB4/NDUFAB1/NDUFS5/GNB2/NDUFB5/NDUFB11/NDUFB9/NDUFA1/GABRP/NDUFV2/NDUFB8/NDUFA5/NDUFA8/NDUFA2/NDUFA4/GNAQ/NDUFS7/NDUFA11/NDUFC2/NDUFA10/NDUFA9/GNB1/NDUFS2/ITPR3/NDUFA4L2/NDUFV3/GNB5	2.12507576110528
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	58/1759	250/9376	1.23662990335418	AP2S1/AP1M2/LAMTOR2/AP1S1/ATP6V1D/OSBPL1A/LAMTOR5/BORCS7/VPS29/ATP6AP1/BLOC1S1/CTSV/SUMF1/SORT1/CLTB/ATP6V1F/LAMTOR1/VPS35/LAMP1/LAMTOR4/ATP6V1G1/RRAGA/ATP6V1E1/CTSF/VPS26A/VAMP8/CD164/SNAPIN/AP3S1/ASAH1/SMPD1/BLOC1S2/RRAGC/CLTA/ATP6V0E1/MLST8/VPS41/LAPTM4A/AP3M1/AKT1S1/BORCS8/AP2A1/DTNBP1/AP4M1/MEAK7/HYAL3/BLOC1S4/BLOC1S5/TMEM175/SLC36A4/AP1S3/MTOR/RRAGB/OSBPL5/TTI1/HYAL1/ATP6V0E2/ABCA2	1.82232561016112
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	54/1759	232/9376	1.24067358020819	GSN/MYH14/ITGB6/RRAS/ITGA6/ITGB4/PPP1CB/EZR/BRK1/ACTG1/MYL12B/PFN2/TMSB4X/ITGAV/CYRIB/BAIAP2/NCKAP1/RDX/ACTB/WASF2/ARPC5L/PPP1CA/MAP2K2/ARPC4/ARPC1A/RGCC/DIAPH2/DIAPH1/RAC1/ITGA2/WASL/KRAS/ITGAE/CFL2/RHOA/MYLK/RRAS2/MYL12A/AKT1/PFN1/SSH3/MYL5/ARHGEF12/CFL1/ARPC3/CRK/CYRIA/DIAPH3/MYL11/SRC/PFN4/PDGFD/PAK4/PDGFA	1.78373725220045
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	8/1759	23/9376	1.85401784610821	POLD2/RPA3/RFC1/SSBP1/RFC2/POLD3/RFC5/MLH3	1.97052512672765
NA	NA	hsa03272	Virion - Hepatitis viruses	14/1759	48/9376	1.55467121470533	CD9/TSG101/LAMP1/CD81/CHMP4B/VPS4A/EPCAM/CLDN3/VPS4B/CLDN4/CLDN9/CHMP7/CLDN1/OCLN	1.85135011913444
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/1759	44/9376	1.57486174996124	DYNLL1/VAMP2/DCTN2/DYNC1LI2/DCTN6/RAB11A/DYNC1I2/CREB3/ARHGDIA/RAB5B/DYNC2LI1/GNAS/DYNC2H1	1.83666083810525
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1759	20/9376	1.86560545764639	EBP/MSMO1/SQLE/NSDHL/TM7SF2/CYP2R1/HSD17B7	1.8621577009592
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	34/1759	142/9376	1.27626932716252	CAV2/CAV1/GSTO2/EDN1/GSTP1/SUMO1/ACTG1/TXN/ITGAV/CALM2/SDC1/CALM1/ACTB/TXN2/SUMO2/MGST2/SUMO3/MGST3/RAC1/GSTO1/PRKCZ/RHOA/NQO1/AKT1/MAP2K4/MGST1/KEAP1/BMPR1A/ACVR2A/GSTA4/SRC/CALML5/PDGFA/MAP2K5	1.59407403263049
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	10/1759	33/9376	1.61524282047307	BCAT1/IDH3A/IDH3G/PDHB/DLD/BCKDHB/DLST/GOT1/ACO1/NAGS	1.70132361449628
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1759	17/9376	1.88128281443333	TXNRD2/KYAT3/PAPSS1/MARS1/PSTK/SEPSECS	1.74763855972262
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/1759	17/9376	1.88128281443333	MYH14/LAMP1/PCDH1/PCDH9/PCDH7/PCDH11X	1.74763855972262
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	52/1759	233/9376	1.18959514160162	PDLIM4/THBS1/MYH14/TMOD3/ITGB6/JUP/ITGA6/DSC2/ENO1/ITGB4/NEBL/ACTG1/PLEC/SGCE/SUN1/SPTBN1/CAPZA2/PDLIM1/DSP/ITGAV/DSG2/DAAM1/SDC1/ACTB/TNNT1/TMEM43/DIAPH2/CSRP1/DIAPH1/ATP1A4/PDLIM2/COL4A5/ANK3/ITGA2/TPM4/NID2/TPM3/THBS3/FHL2/MYL5/LMNA/SPTBN2/COL9A3/TNNC2/DIAPH3/COL4A6/ANK2/MYL11/ENO2/TRIM55/VIM/ANKRD2	1.40827472564543
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/1759	18/9376	1.77676710252037	MMADHC/LMBRD1/MMAB/PRDX1/MMUT/THAP11	1.5851199662255
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	10/1759	35/9376	1.52294323073175	TPI1/PFKP/PMM1/ALDOA/SORD/ALDOC/GMDS/FPGT/PMM2/MPI	1.48942439189632
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1759	104/9376	1.28132242970219	PLAAT2/ETNK2/PLAAT3/PCYT2/AGPAT2/LPCAT2/PLPP2/CDIPT/MBOAT2/PLB1/ACHE/PLA2G4A/SGMS2/PCYT1A/PEMT/GNPAT/TAFAZZIN/CDS1/PLPP5/DGKA/AGPAT3/DGKB/SELENOI/PTDSS1/LPCAT4	1.38631172996686
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	32/1759	138/9376	1.23601189740548	ANAPC16/PPP1CB/ANAPC11/CDC26/RBX1/YWHAH/ANAPC13/PPP3CA/CALM2/YWHAQ/CALM1/PPP2CB/PPP1CA/SLK/PPP2R1A/ANAPC5/PPP3CC/YWHAB/ANAPC15/ITPR3/PPP3CB/SMC3/MAD2L2/CDC16/CDC27/YWHAZ/FBXW11/BTRC/RPS6KA2/PPP2R5B/PPP2R1B/CALML5	1.34218085828526
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/1759	67/9376	1.35246451087372	GAPDH/TPI1/PFKP/ENO1/PGAM1/PKM/PGK1/PGM1/ALDOA/PDHB/BPGM/DLD/ALDOC/ALDH3B1/G6PC3/ENO2/PGAM4	1.39132266961308
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1759	158/9376	1.21449903210253	WNT2/WNT5A/LAMTOR2/EIF4E2/CLIP1/ATP6V1D/LAMTOR5/ATP6V1F/LAMTOR1/MAP2K2/LAMTOR4/ATP6V1G1/DVL1/RRAGA/ATP6V1E1/SEC13/MAPKAP1/KRAS/RHOA/RRAGC/MLST8/AKT1/WNT11/AKT1S1/FZD6/RPS6/WNT7A/CAB39L/NPRL2/WNT2B/MIOS/RPS6KA2/MTOR/NPRL3/RRAGB/TTI1	1.30665853187393
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	20/1759	82/9376	1.30007348964905	GSTO2/GSTP1/NME3/DUT/CMPK1/NME1/TPMT/MGST2/MGST3/GMPS/ITPA/GSTO1/RRM1/NME4/MGST1/UCK1/NME6/GSTA4/NME7/CES2	1.31147435027261
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1759	19/9376	1.68325304449298	PDHB/DLD/BCKDHB/DLST/LIAS/LIPT1	1.43257260331103
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	11/1759	41/9376	1.43008083861396	POLD2/RPA3/SEM1/NBN/SSBP1/BABAM1/POLD3/RBBP8/ABRAXAS1/UIMC1/BARD1	1.32620738274551
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/1759	15/9376	1.77676710252037	ACP1/AK2/NTPCR/AK4/THTPA	1.4467780499966
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/1759	103/9376	1.24201195515987	PPP1CB/UPF3A/SRRM1/SSU72/PPP2CB/PPP1CA/PPP2R1A/MAGOHB/PPP2R2A/SAP18/ALYREF/RNMT/MSI2/HBS1L/PPP2R3A/PYM1/CSTF3/NXT2/PELO/PPP2R2B/SMG6/PPP2R5B/PPP2R1B/CLP1	1.18678454716146
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	17/1759	70/9376	1.29450174612198	BAD/RAP1A/ELOB/RBX1/ELOC/MAP2K2/SLC2A1/MET/RAC1/FH/KRAS/EGLN3/AKT1/PTPN11/PRCC/CRK/PAK4	1.18845283270448
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1759	47/9376	1.36092799341986	GRHPR/PKM/ACYP2/MDH2/MDH1/HAGH/GLO1/ACAT2/PDHB/DLD/FH/ACYP1	1.19200624201646
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	44/1759	203/9376	1.15533624400339	EMP1/CCND1/EMP2/THBS1/CAV2/CAV1/ITGB6/LAMB3/CAPN2/VEGFB/ITGA6/BAD/ITGB4/PPP1CB/RAP1A/ACTG1/MYL12B/ITGAV/CCND3/ACTB/PPP1CA/MET/LAMC2/DIAPH1/RAC1/COL4A5/ITGA2/RHOA/MYLK/MYL12A/THBS3/AKT1/FYN/MYL5/SHC3/COL9A3/CRK/RASGRF1/COL4A6/MYL11/SRC/PDGFD/PAK4/PDGFA	1.07520605672631
Genetic Information Processing	Transcription	hsa03040	Spliceosome	52/1759	243/9376	1.14064060902542	SF3B5/LSM5/THOC7/TXNL4A/LSM4/SNRPF/LSM3/SNU13/SF3B6/SNRPE/SNRPC/ZMAT2/U2AF1/CWC15/SNRPB2/SLU7/PPIE/SNRPA1/SNRPG/SYF2/SNW1/WBP11/SNRPD1/MAGOHB/SRSF9/BUD31/SNRPB/ALYREF/SNRPD2/SF3A3/SF3B2/LSM6/RP9/PQBP1/SRSF8/SRSF4/PRPF6/RBMX2/PHF5A/PLRG1/PCBP1/SNRPA/PPIH/PPIL1/CDC40/SF3A2/THOC6/SART1/THOC3/THOC5/HNRNPA1L3/RBMXL1	1.06741604457218
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	28/1759	125/9376	1.19398749289369	ORMDL2/CERS6/DEGS1/GNAQ/PPP2CB/SPTSSA/MAP2K2/PPP2R1A/PPP2R2A/TRADD/ASAH1/RAC1/CERS2/SMPD1/PRKCZ/KRAS/RHOA/SGMS2/PPP2R3A/AKT1/SPTLC3/FYN/PPP2R2B/SMPD2/PPP2R5B/SGPP2/PPP2R1B/TRAF2	1.04920650950815
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	43/1759	200/9376	1.14601478112564	GAPDH/MYH14/TUBA4A/EZR/TMED10/BRK1/ACTG1/TUBB6/MYO6/BAIAP2/NCKAP1/ARF6/ACTB/WASF2/ARPC5L/ARPC4/ARPC1A/TRADD/MYO1C/MYO5B/ARF1/RAC1/WASL/CLDN3/TUBA1A/RHOA/TUBB4B/CLDN4/MYO1E/FYN/PTPN11/MYO1D/ARHGEF12/FADD/IRAK4/ARPC3/CLDN9/CLDN1/SRC/OCLN/TRAF2/TRAF6/RPS3	1.00302486034472
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1759	21/9376	1.52294323073175	PPCS/BCAT1/AASDHPPT/ENPP1/PANK2/PPCDC	1.15283957647791
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/1759	44/9376	1.33257532689028	OSTC/DAD1/KRTCAP2/TMEM258/ALG3/B4GALT2/ALG14/MAGT1/B4GALNT3/ALG1/ALG11	1.06256517964644
NA	NA	hsa04519	Cadherin signaling	83/1759	404/9376	1.09508665477122	KRT6A/KRT5/KRT14/KRT17/KRT24/DSG1/DSC3/KRT19/KRT16/JUP/RRAS/WNT2/WNT5A/DSC2/PKP3/PPP1CB/BRK1/PSENEN/ACTG1/KRT8/KRT10/KRT18/DSP/DSG2/YAP1/YWHAH/PKP1/NCKAP1/GABRP/DAAM1/YWHAQ/CTNNA1/ACTB/GJA1/ARPC5L/PPP1CA/MAP2K2/ARPC4/ARPC1A/DVL1/CIB2/MET/YWHAB/MYO1C/RAC1/KRT13/WWTR1/AMOTL1/KRAS/RHOA/RRAS2/KRT15/MYO1E/YWHAZ/WNT11/SHOC2/FZD6/PCDH1/KRT6C/MYO1D/RYK/KRT27/WNT7A/KRT6B/ARPC3/PCDH9/KRT78/PCDH7/WNT2B/DSG3/KRT72/VIM/PRICKLE1/NF2/VANGL1/PCDH11X/CDH2/DSC1/PCDHGA10/CDH10/KRT80/CDH16/KRT9	0.938841327929023
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	34/1759	157/9376	1.15433276724253	CCND1/RRAS/CAPN2/CDK6/VDAC2/VDAC1/CAPN1/PPP1CB/PPP3CA/CALM2/CCND3/CALM1/PPP1CA/MAP2K2/NBN/PPP3CC/SLC25A4/ITPR3/PPP3CB/KRAS/SMAD2/RRAS2/PPID/AKT1/GADD45A/NFATC3/HUS1/CDKN2B/IGFBP3/FBXW11/BTRC/MTOR/TRAF3IP2/CALML5	0.937114466296062
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/1759	59/9376	1.26481725942128	GSTO2/GSTP1/GGCT/SMS/GSTK1/MGST2/MGST3/GSTO1/RRM1/MGST1/LANCL1/PRDX6/GSTA4/GGT6	0.980529862773671
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	9/1759	36/9376	1.33257532689028	POLD2/RPA3/RFC1/SSBP1/POLE4/POLE3/RFC2/POLD3/RFC5	0.96071466258337
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	8/1759	32/9376	1.33257532689028	GABARAPL2/PPP2CB/IGBP1/MLST8/ATG5/ATG10/MTOR/ATG9B	0.905576577407241
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	9/1759	37/9376	1.29655977751487	CMAS/GALE/PGM1/PMM1/UXS1/GMDS/FPGT/PMM2/MPI	0.868539354633154
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1759	28/9376	1.33257532689028	B3GNT3/B4GALT4/A4GALT/ST3GAL4/B4GALT2/FUT3/ABO	0.846908068800951
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	35/1759	168/9376	1.11047943907523	H2AZ1/MACROH2A1/H2AJ/H2AZ2/CAPN2/VDAC2/VDAC1/CHMP2A/CAPN1/PPIA/CHMP2B/H2AC6/CHMP4C/GLUD1/CHMP3/CHMP5/CHMP4B/IFNAR1/SHARPIN/TRADD/VPS4A/SLC25A4/SMPD1/PLA2G4A/VPS4B/PPID/HMGB1/CHMP6/FADD/H2AX/CHMP7/H2AC20/SPATA2L/TRAF2/MACROH2A2	0.694352536384661
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	33/1759	158/9376	1.11329077942732	SFN/CCND1/CDK6/ANAPC16/ANAPC11/CDC26/RBX1/YWHAH/ANAPC13/CCND3/YWHAQ/PPP2CB/PPP2R1A/ANAPC5/YWHAB/ANAPC15/ORC4/WEE1/SMC3/MAD2L2/CDC16/HDAC2/SMAD2/CDC27/HDAC1/YWHAZ/GADD45A/ORC3/CDKN2B/FZR1/ORC5/PPP2R5B/PPP2R1B	0.69013068297015
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1759	10/9376	1.59909039226833	ETHE1/BPNT2/PAPSS1	0.910839504126334
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1759	34/9376	1.25418854295556	RBX1/NR1D1/DBP/PER3/NPAS2/FBXW11/CLOCK/BTRC	0.713513309907442
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1759	71/9376	1.12611999455516	PFKP/PGAM1/PKM/SLC1A5/MAP2K2/SLC2A1/MET/PDHB/KRAS/PDK1/AKT1/SIRT3/MTOR/PGAM4/NTRK3	0.512603431437492
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1759	107/9376	1.09594980155462	PFKP/PGAM1/PKM/PPP3CA/CALM2/GNAQ/CALM1/SLC2A1/CREB3/PPP3CC/PPP4R3B/PDHB/ITPR3/PPP3CB/AKT1/SIK1/G6PC3/GNAS/PPARA/PGAM4/CALML5/PHKG1	0.479673922596276
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/1759	133/9376	1.08209124288835	TH/PPP1CB/GNB2/KIF5B/COMT/PPP3CA/CALM2/GNAQ/CALM1/PPP2CB/PPP1CA/PPP2R1A/CREB3/PPP2R2A/PPP3CC/GNB1/ITPR3/PPP3CB/PPP2R3A/AKT1/GNB5/PPP2R2B/CLOCK/GNAS/PPP2R5B/PPP2R1B/CALML5	0.458186991824161
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/1759	26/9376	1.2300695325141	PLAAT2/PLAAT3/ACAA1/PLB1/ACOX1/PLA2G4A	0.564503395700803
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1759	36/9376	1.18451140168025	B3GNT3/C1GALT1/GALNT3/GCNT1/GALNT11/GALNT5/ST6GALNAC1/GALNTL6	0.533000480418998
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1759	170/9376	1.06606026151222	IGF2/CCND1/WNT2/GSTO2/CDK6/GSTP1/WNT5A/BAD/TXNRD2/ACTG1/BRD7/ACTB/MAP2K2/DVL1/MGST2/MET/ACTL6A/MGST3/GSTO1/KRAS/SMAD2/NQO1/BCL2L1/AKT1/WNT11/GADD45A/FZD6/MGST1/KEAP1/WNT7A/SHC3/GSTA4/WNT2B/MTOR	0.417691698753411
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/1759	67/9376	1.11379430307247	PPP1CB/RAP1A/PPP3CA/CALM2/GNAQ/CALM1/PPP1CA/MAP2K2/PPP3CC/ITPR3/PPP3CB/KRAS/RPS6KA2/CALML5	0.449193007106117
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1759	37/9376	1.15249758001321	CCND1/CCDC6/TFG/MAP2K2/TPR/KRAS/TPM3/GADD45A	0.446622097027825
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	31/1759	156/9376	1.05922654188714	CCND1/CDK6/BAD/YWHAH/YWHAQ/PPP2CB/MAP2K2/PPP2R1A/CD81/PPP2R2A/IFNAR1/EIF2S1/TRADD/YWHAB/EIF3E/KRAS/CLDN3/CLDN4/YWHAZ/AKT1/PSME3/FADD/PPP2R2B/CLDN9/CLDN1/OCLN/PPARA/PPP2R1B/TRAF2/TRAF6/RNASEL	0.358459252342959
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1759	17/9376	1.25418854295556	SCP2/CYP7B1/HSD3B7/SLC27A5	0.504071668973233
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/1759	79/9376	1.07955469520225	AP2S1/VAMP2/ATP6V1D/CLTB/ATP6V1F/ATP6V1G1/ATP6V1E1/NAPA/SLC1A6/CLTA/ATP6V0E1/AP2A1/SLC18A3/STXBP1/ATP6V0E2/SLC6A9	0.341220037578429
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	36/1759	184/9376	1.04288503843587	RHOD/RRAS/WNT5A/NGEF/MYL12B/PPP3CA/ABLIM3/DPYSL2/SEMA3C/MET/PPP3CC/RAC1/SLIT2/PRKCZ/PPP3CB/KRAS/CFL2/RHOA/MYL12A/FYN/PTPN11/SSH3/MYL5/NFATC3/PARD6B/RYK/ARHGEF12/CFL1/EFNA5/PLXNB1/RGS3/SRC/EPHA4/EFNA3/EPHA2/PAK4	0.282316517031531
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1759	38/9376	1.12216869632866	GALE/PGM1/PMM1/UXS1/FPGT/PMM2/MPI/GNPDA2	0.36261969072135
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1759	38/9376	1.12216869632866	NT5C/NT5E/NMRK1/ENPP1/NADK2/SIRT3/NMNAT1/NT5DC4	0.36261969072135
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/1759	28/9376	1.14220742304881	TH/PTS/PCBD1/MOCS2/QDPR/SPR	0.362133340285828
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1759	28/9376	1.14220742304881	ATP6V1D/ATP6V1F/ATP6V1G1/ATP6V1E1/ATP6V0E1/ATP6V0E2	0.362133340285828
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1759	54/9376	1.08580211820689	BCAT1/SMS/CISD1/MDH2/MDH1/KYAT3/ENOPH1/AHCYL1/AHCY/APIP/GOT1	0.303855372951497
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/1759	75/9376	1.06606026151222	PERP/SFN/CCND1/THBS1/TP53I3/CDK6/SERPINB5/EI24/CCND3/SIVA1/PPP1R13L/BCL2L1/GADD45A/IGFBP3/CCNG1	0.276014996092885
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1759	44/9376	1.09028890381932	GTF2H5/GTF2F2/GTF2A2/MNAT1/TAF11/GTF2E2/TAF12/TBPL1/GTF2H3	0.288469521187618
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/1759	86/9376	1.05366421195976	ITGB6/JUP/ITGA6/DSC2/ITGB4/ACTG1/SGCE/DSP/ITGAV/DSG2/CTNNA1/ACTB/GJA1/ITGA2/LMNA/CDH2/CACNA2D3	0.240244085685753
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1759	55/9376	1.06606026151222	KDSR/CERS6/DEGS1/PLPP2/ASAH1/CERS2/SMPD1/SGMS2/SPTLC3/SMPD2/SGPP2	0.236111401723324
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	41/1759	214/9376	1.02122595144862	AP1M2/BAD/RNF7/GNB2/AP1S1/ELOB/RBX1/PPP3CA/CALM2/GNAQ/CALM1/ELOC/MAP2K2/TRADD/PPP3CC/GNB1/RAC1/ITPR3/PPP3CB/CUL5/KRAS/CFL2/WEE1/BCL2L1/AKT1/GNB5/NFATC3/CFL1/GNA11/FADD/FBXW11/IRAK4/APOBEC3C/CRK/AP1S3/BTRC/MTOR/PAK4/CALML5/TRAF2/TRAF6	0.150940397578838
Organismal Systems	Sensory system	hsa04744	Phototransduction	6/1759	29/9376	1.10282096018506	RGS9/CALM2/CALM1/GNB1/CNGA1/CALML5	0.26648398422735
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	63/1759	333/9376	1.00843538251156	CCND1/THBS1/ITGB6/WNT2/LAMB3/CDK6/WNT5A/ITGA6/BAD/ITGB4/PKM/ATP6V1D/ITGAV/LLGL2/PSMC1/ATP6AP1/CCND3/PPP2CB/ATP6V1F/MAP2K2/PPP2R1A/BCAP31/ATP6V1G1/DVL1/CREB3/ATP6V1E1/PPP2R2A/RFNG/IFNAR1/LAMC2/TRADD/CRB3/COL4A5/ITGA2/PRKCZ/TUBG1/KRAS/UBR4/HDAC2/ATP6V0E1/HDAC1/THBS3/PPP2R3A/AKT1/WNT11/FZD6/PARD6B/TBPL1/PATJ/FADD/WNT7A/DLG3/COL9A3/PPP2R2B/WNT2B/COL4A6/MTOR/GNAS/PRKCI/TUBG2/PPP2R5B/PPP2R1B/ATP6V0E2	0.0753177282732883
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1759	51/9376	1.04515711912963	PLAAT2/PLAAT3/LPCAT2/PLPP2/PEDS1/PLB1/PLA2G4A/PAFAH1B2/SELENOI/LPCAT4	0.155386568347972
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1759	46/9376	1.04288503843587	EPRS1/MMAB/BLVRA/BLVRB/UROS/UROD/PPOX/HCCS/ALAD	0.140110433814689
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/1759	73/9376	1.02224956583364	MAP1B/PPIA/PIN1/TSG101/MDFIC/SERINC3/RAN/CHMP4B/VPS4A/KAT2B/VPS4B/SERINC5/CHMP6/APOBEC3C	0.0917060611444635
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1759	41/9376	1.04005879171924	GRHPR/PGAM1/BPGM/DLD/PSPH/SRR/GCAT/PGAM4	0.123526231703639
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1759	122/9376	1.00489286945824	CCND1/PFKP/ADIPOR1/RAB2A/RAB10/PPP2CB/PPP2R1A/CREB3/PPP2R2A/RAB14/TBC1D1/HMGCR/PPP2R3A/AKT1/SCD5/AKT1S1/CAB39L/PPP2R2B/G6PC3/LEPR/MTOR/PPP2R5B/PPP2R1B	0.0261399875757043
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1759	63/9376	1.0152954871545	ECHS1/HADHA/ACAT2/DLD/SMYD2/SETD7/DLST/KMT5A/TMLHE/CAMKMT/MECOM/SMYD3	0.0585349655388514
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1759	20/9376	1.06606026151222	CYB5R3/CYB5R1/CMAS/GMDS	0.142113966144397
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1759	31/9376	1.03167122081828	ECHS1/HADHA/ACOX1/SMOX/HIBCH/ALDH3B1	0.0848755454871552
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1759	69/9376	1.00425966664195	EDN1/PPP3CA/CALM2/GNAQ/CALM1/KCNMA1/PPP3CC/ITPR3/PPP3CB/GUCY1A1/EDN2/GNAS/CALML5	0.0170656125524202
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1759	69/9376	1.00425966664195	TH/PPP1CB/PPP3CA/CALM2/CALM1/PPP1CA/CREB3/PPP3CC/PPP3CB/HDAC2/HDAC1/GNAS/CALML5	0.0170656125524202
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1759	134/9376	0.99445919917185	MYH14/EDN1/KCNMB4/PPP1CB/CALM2/GNAQ/CALM1/PPP1CA/MAP2K2/AVPR1A/KCNMA1/ITPR3/MYL6B/PLA2G4A/RHOA/MYLK/GUCY1A1/MYL6/ARHGEF12/ADRA1B/GNA11/EDN2/ADORA2B/GNAS/CALML5	-0.0310433467790309
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	38/1759	204/9376	0.992899263173149	IGF2/CCND1/THBS1/CAV2/CAV1/RRAS/WNT2/WNT5A/PPP1CB/EZR/ACTG1/ITGAV/RDX/SDC1/ACTB/PPP1CA/MAP2K2/MET/RAC1/ITPR3/ANK3/ITGA2/KRAS/RHOA/LUM/SMAD2/RRAS2/AKT1/WNT11/FZD6/PTPN11/RPS6/ARHGEF12/WNT7A/WNT2B/ANK2/MTOR/SRC	-0.0492734597658476
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1759	26/9376	1.02505794376175	LMBRD1/AMN/PLB1/BTD/CUBN	0.0614826925939101
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/1759	75/9376	0.994989577411408	GSTO2/GSTP1/BAD/XPA/MGST2/ERCC1/MGST3/GSTO1/BCL2L1/AKT1/MGST1/FADD/ABCC2/GSTA4	-0.0209347002200113
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	33/1759	178/9376	0.988201927806274	CCND1/WNT2/WNT5A/CTNNBIP1/RBX1/PPP3CA/DAAM1/CCND3/CACYBP/DVL1/PPP3CC/RAC1/CBY1/PPP3CB/RHOA/LGR5/ROR2/PORCN/SFRP2/WNT11/FZD6/RUVBL1/NFATC3/SENP2/RYK/WNT7A/FBXW11/WNT2B/BTRC/LGR4/PRICKLE1/VANGL1/DKK2	-0.0763661555934822
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1759	43/9376	0.991683964197417	ACSL3/ECHS1/HADHB/HADHA/ACAA1/ECI1/ACAT2/ACOX1	-0.0262643420308865
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/1759	49/9376	0.979034934041837	C1GALT1/RFNG/B4GALT2/GALNT3/GALNT11/FUT11/GALNT5/GALNTL6/XXYLT1	-0.0707049573832824
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1759	60/9376	0.977221906386204	BAD/PPP3CA/MAP2K2/MAPKAPK3/PPP3CC/RAC1/PPP3CB/PLA2G4A/KRAS/AKT1/SRC	-0.0850559772728208
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1759	60/9376	0.977221906386204	GNAQ/PPP2CB/MAP2K2/PPP2R1A/ITPR3/PLA2G4A/KRAS/GUCY1A1/GNA11/GNAS/PPP2R1B	-0.0850559772728208
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1759	38/9376	0.981897609287574	SFN/ATP1A4/KRAS/NEDD4L/FXYD4/NR3C2/SCNN1A	-0.0537313036704426
Organismal Systems	Immune system	hsa04611	Platelet activation	23/1759	126/9376	0.97299150852306	PPP1CB/RAP1A/ACTG1/MYL12B/GNAQ/ACTB/PPP1CA/VAMP8/ITPR3/ITGA2/PRKCZ/PLA2G4A/RHOA/MYLK/MYL12A/AKT1/GUCY1A1/FYN/STIM1/ARHGEF12/GNAS/PRKCI/SRC	-0.146670007519958
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/1759	77/9376	0.969145692283839	CCND1/CDK6/BAD/MAP2K2/KRAS/HDAC2/HDAC1/BCL2L1/AKT1/GADD45A/PTPN11/SHC3/CRK/MECOM	-0.130638030808364
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1759	110/9376	0.969145692283839	GAPDH/PFKP/EDN1/ENO1/EIF4E2/PGK1/ELOB/RBX1/ELOC/MAP2K2/SLC2A1/ALDOA/PDHB/PDK1/EGLN3/AKT1/ALDOC/RPS6/MTOR/ENO2	-0.156420107957202
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/1759	110/9376	0.969145692283839	THBS1/ID4/RBX1/EMP3/PPP2CB/PPP2R1A/NBL1/RHOA/HDAC2/SMAD2/THSD4/HDAC1/TMEM53/CDKN2B/BMPR1A/ACVR2A/SMURF1/SMAD1/BMP2/PPP2R1B	-0.156420107957202
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1759	138/9376	0.965634294848028	ACTG1/BAIAP2/ARF6/GNAQ/ACTB/WASF2/ARPC5L/MAP2K2/ARPC4/ARPC1A/RAC1/WASL/RHOA/SKAP2/AKT1/MAP2K4/NFATC3/ARHGEF12/IRAK4/ARPC3/CRK/RPS6KA2/SRC/TRAF2/TRAF6	-0.195435027401216
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1759	89/9376	0.958256414842448	TUBA4A/TUBB6/GNAQ/GJA1/MAP2K2/ITPR3/KRAS/TUBA1A/TUBB4B/GUCY1A1/GNA11/GNAS/SRC/PDGFD/PDGFA/MAP2K5	-0.190140051189428
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/1759	155/9376	0.962893139430395	THBS1/TUBA4A/ACTG1/TUBB6/SEC61G/ATP6V1D/ITGAV/VAMP3/ATP6AP1/DYNC1LI2/DYNC1I2/ACTB/ATP6V1F/LAMP1/ATP6V1G1/ATP6V1E1/STX7/SEC61B/RAC1/ITGA2/TUBA1A/TUBB4B/ATP6V0E1/RAB5B/THBS3/STX18/ATP6V0E2/DYNC2H1	-0.223850274134935
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1759	205/9376	0.962054382340299	CCND1/CDK6/PSMD8/CD40/PSMD7/PSMC5/PSMC3/PSMC1/PSMD6/PSMD4/CCND3/PSMD14/SEM1/PSMD2/PSMC6/SNW1/PSMD13/CIR1/PSMC2/IFNAR1/PSMD12/TRADD/RAC1/PSMD1/BLNK/PSMD11/HDAC2/HDAC1/AKT1/GADD45A/MAP2K4/FADD/IRAK4/NEDD4/VIM/TRAF2/TRAF6	-0.263971348111913
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1759	17/9376	0.940641407216667	GLUD1/CA5B/CA13	-0.117711776401459
NA	NA	hsa04517	IgSF CAM signaling	54/1759	299/9376	0.962663112402342	LMO7/MYH14/TUBA4A/DYNLL1/SLITRK6/EZR/RAP1A/ACTG1/MYL12B/TUBB6/SPTBN1/BAIAP2/CD2AP/RDX/ARF6/APP/ACTB/ARPC5L/MAP2K2/ARPC4/ARPC1A/NECTIN4/RAC1/SLIT2/ANK3/MBP/MYL6B/WASL/TUBA1A/RHOA/TUBB4B/MYLK/MYL12A/AKT1/FYN/PTPN11/NECTIN3/PARD6B/CADM1/MYL6/SPTBN2/MAP2/ARPC3/PALS2/IL1RAPL2/ANK2/CXADR/PRKCI/SRC/CADM4/PAK4/CDH2/NTRK3/TRAF6	-0.31530373761573
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1759	23/9376	0.927008923054107	MDH1/GLUD1/ATP1A4/SLC9A3	-0.168416563897622
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1759	80/9376	0.932802728823195	BAD/EIF4E2/GAS6/MAP2K2/MET/KRAS/BCL2L1/AKT1/RPS6/SHC3/MTOR/SRC/PDGFD/PDGFA	-0.290051524999108
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	21/1759	120/9376	0.932802728823195	BAD/RAP1A/CALM2/SORT1/CALM1/MAP2K2/ARHGDIA/RAC1/KRAS/RHOA/AKT1/PTPN11/SHC3/IRAK4/CRK/NGF/RPS6KA2/CALML5/NTRK3/TRAF6/MAP2K5	-0.356005876868207
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/1759	70/9376	0.913765938439048	ADIPOR1/ACSL3/APPL1/SLC2A1/TRADD/AKT1/PTPN11/G6PC3/LEPR/MTOR/PPARA/TRAF2	-0.347994930716898
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1759	18/9376	0.888383551260186	ACSL3/MCAT/OXSM	-0.227771568701346
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1759	53/9376	0.905145505057548	AP2S1/ATP2B4/RAB11A/CLTB/GNAQ/ATP1A4/CLTA/AP2A1/GNAS	-0.332770323400868
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	27/1759	154/9376	0.934533346130845	CCND1/PPP1CB/ACTG1/PPP3CA/CALM2/CAMK1D/GNAQ/CALM1/ACTB/PPP1CA/MAP2K2/PPP3CC/ITPR3/MYL6B/PPP3CB/PLA2G4A/KRAS/RHOA/MYLK/GUCY1A1/NFATC3/MYL6/GNAS/SRC/CALML5/CACNA2D3/MAP2K5	-0.393635742084216
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/1759	76/9376	0.911762065767033	CCND1/CDK6/CALM2/CAMK1D/CALM1/MAP2K2/KRAS/AKT1/GADD45A/SHC3/MTOR/CALML5/PDGFA	-0.371148093594421
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1759	138/9376	0.927008923054107	BAD/PPP1CB/EIF4E2/CALM2/CALM1/PPP1CA/MAP2K2/TRIP10/PRKCZ/KRAS/PPP1R3F/AKT1/EXOC7/RPS6/PRKAR2B/SOCS4/SHC3/CRK/G6PC3/MTOR/PRKCI/CALML5/PHKG1/PPP1R3E	-0.415094439642141
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1759	71/9376	0.900895995644132	ATP6V1D/ATP6AP1/ATP6V1F/ATP6V1G1/ATP6V1E1/MET/RAC1/ATP6V0E1/MAP2K4/PTPN11/SRC/ATP6V0E2	-0.402799356923487
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	24/1759	139/9376	0.920339794111272	KRT14/KRT17/KRT24/KRT19/KRT16/KRT10/KRT18/EBAG9/CALM2/GNAQ/CALM1/MAP2K2/CREB3/ITPR3/KRT13/KRAS/KRT15/AKT1/KRT27/SHC3/GNAS/SRC/CALML5/KRT9	-0.454684273282778
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1759	83/9376	0.899086967540429	POLR2L/POLR2K/POLR2E/POLR2F/PCBP1/ZDHHC1/POLR1C/POLR3K/FADD/POLR3H/POLR3D/POLR3F/POLR3C/POLR3G	-0.443746473571382
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1759	37/9376	0.86437318500991	TH/COMT/FAHD1/GSTZ1/ALDH3B1/GOT1	-0.397212418182832
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1759	61/9376	0.873819886485429	ATOX1/ATP2B4/MT1E/ATP1A4/STEAP1/MT1F/CYBRD1/MT1G/SLC26A3/SLC9A3	-0.475106510598366
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1759	32/9376	0.832859579306424	PFKP/GALE/PGM1/B4GALT2/G6PC3	-0.455110279927742
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/1759	238/9376	0.918245183235318	IGF2/RRAS/VEGFB/BAD/PLAAT2/RAP1A/RALB/GNB2/PLAAT3/RALA/ARF6/CALM2/CALM1/MAP2K2/MET/GNB1/RAC1/PLA2G4A/KRAS/RHOA/RRAS2/RASAL2/RAB5B/BCL2L1/AKT1/SHOC2/GNB5/PTPN11/SHC3/EFNA5/RASGRF1/BRAP/NGF/RIN1/EFNA3/PDGFD/EPHA2/PAK4/CALML5/PDGFA/KSR2	-0.613907347599967
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/1759	137/9376	0.894868102729238	TUBA4A/CAPN2/BAD/NOL3/CAPN1/ACTG1/CTSV/ACTB/MAP2K2/CTSF/EIF2S1/TRADD/ITPR3/KRAS/TUBA1A/BCL2L1/AKT1/GADD45A/LMNA/FADD/CASP6/NGF/TRAF2	-0.595674326104993
NA	NA	hsa04518	Integrin signaling	26/1759	154/9376	0.89992099997785	CCND1/THBS1/ITGB6/LAMB3/VEGFB/ITGA6/ITGB4/ACTG1/ITGAV/CCND3/ACTB/MET/LAMC2/RAC1/COL4A5/ITGA2/ITGAE/FERMT1/THBS3/AKT1/COL9A3/COL4A6/MTOR/SRC/PDGFD/PDGFA	-0.601751718050248
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1759	86/9376	0.86772346867274	KCNN4/VAMP2/KCNMB4/GNAQ/SLC2A1/CREB3/KCNMA1/ATP1A4/ITPR3/RIMS2/GNA11/TRPM4/PCLO/GNAS	-0.592175924436058
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	28/1759	166/9376	0.899086967540429	VDAC2/VDAC1/BAD/KCNMB4/PPP1CB/PPP3CA/ATP2B4/CALM2/GNAQ/CALM1/PPP1CA/MAP2K2/CREB3/KCNMA1/PPP3CC/SLC25A4/ATP1A4/ITPR3/PPP3CB/RHOA/MYLK/AKT1/GUCY1A1/NFATC3/ADRA1B/GNA11/CNGA1/CALML5	-0.630373671746893
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1759	14/9376	0.761471615365873	B4GALT4/B4GALT2	-0.429186790333177
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/1759	98/9376	0.870253274703855	GSN/ASAP2/ARF6/PLPP2/WASF2/ARPC5L/ARPC4/ARPC1A/ASAP1/RAC1/PLA2G4A/CFL2/AKT1/CFL1/ARPC3/CRK	-0.620452929289505
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1759	27/9376	0.789674267786832	ECHS1/HADHA/ACAT2/HMGCL	-0.525918310807989
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/1759	87/9376	0.85774963569949	CCND1/BAD/RALB/AREG/RALA/APPL1/MAP2K2/RAC1/KRAS/RHOA/SMAD2/AKT1/GADD45A/MTOR	-0.640553063068557
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/1759	93/9376	0.859726017348567	CCND1/LAMB3/CDK6/ITGA6/ITGAV/LAMC2/COL4A5/ITGA2/BCL2L1/AKT1/GADD45A/CDKN2B/COL4A6/TRAF2/TRAF6	-0.653282473315174
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	20/1759	122/9376	0.873819886485429	CCND1/PFKP/BAD/ACTG1/ITGAV/PLCD1/ACTB/MAP2K2/SLC2A1/ATP1A4/MED4/KAT2B/KRAS/HDAC2/HDAC1/AKT1/MED30/MED27/MTOR/SRC	-0.674112936738023
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	16/1759	99/9376	0.861462837585635	PLPP2/WASF2/SLC44A2/MAP2K2/RAC1/PLA2G4A/KRAS/SLC44A3/PCYT1A/AKT1/DGKA/SLC44A1/DGKB/MTOR/PDGFD/PDGFA	-0.665896430814165
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1759	52/9376	0.820046355009402	VDAC2/VDAC1/VAPA/TSPO/LRPAP1/SORT1/VAPB/OSBPL5	-0.625299047753578
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1759	76/9376	0.841626522246492	EZR/ACTG1/CALM2/GNAQ/CALM1/ACTB/ATP1A4/ITPR3/KCNJ15/MYLK/GNAS/CALML5	-0.66615356371491
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1759	77/9376	0.830696307671862	CCND1/CDK6/BAD/RALB/RALA/RAC1/KRAS/SMAD2/BCL2L1/AKT1/GADD45A/MTOR	-0.716836727558411
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	16/1759	101/9376	0.844404167534434	WNT2/EDN1/WNT5A/CALM2/GNAQ/CALM1/MAP2K2/DVL1/CREB3/KRAS/WNT11/FZD6/WNT7A/WNT2B/GNAS/CALML5	-0.75548921404298
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	34/1759	205/9376	0.884049972961356	CCND1/GSN/CDK6/BAD/PKM/YWHAH/PSMC1/GTF2A2/RANBP1/CCND3/YWHAQ/SNW1/H4C3/CREB3/TRADD/YWHAB/RAC1/KAT2B/KRAS/UBR4/RHOA/SND1/GTF2E2/HDAC2/HDAC1/YWHAZ/TBPL1/CDKN2B/HDAC11/GTF2H3/H2BC5/SRC/TRAF2/H2BC21	-0.806614487751749
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1759	54/9376	0.789674267786832	RPA3/CENPX/USP1/ERCC1/FANCF/RMI2/ERCC4/CENPS	-0.744837133843559
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1759	42/9376	0.761471615365873	ECHS1/KYAT3/HADHA/ACAT2/DLD/DLST	-0.744487472219504
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1759	42/9376	0.761471615365873	VDAC2/ACSL3/MAP1LC3A/SAT2/PCBP1/ATG5	-0.744487472219504
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	24/1759	149/9376	0.858572022694408	RRAS/RALB/RALA/ARF6/AGPAT2/PLPP2/MAP2K2/AVPR1A/ARF1/PLA2G4A/KRAS/RHOA/RRAS2/AKT1/FYN/PTPN11/DGKA/SHC3/AGPAT3/DGKB/MTOR/GNAS/PDGFD/PDGFA	-0.836228152031269
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1759	16/9376	0.666287663445139	ALDH3B1/GOT1	-0.641979128513837
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1759	16/9376	0.666287663445139	A4GALT/ABO	-0.641979128513837
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	12/1759	79/9376	0.809666021401688	GSTO2/GSTP1/AKR7A2/GSTK1/MGST2/MGST3/HSD11B1L/GSTO1/MGST1/ALDH3B1/GSTA4/CBR3	-0.816366239159825
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1759	23/9376	0.69525669229058	GLUD1/GOT1/NAGS	-0.70315198655394
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1759	109/9376	0.8313313965921	PPP1CB/SLC27A6/PPP1CA/SLC2A1/CREB3/NR1H2/PRKCZ/AKT1/PTPN11/G6PC3/SLC27A4/RPS6KA2/MTOR/TRIB3/PPARA/SLC27A5/PPP1R3E	-0.851146850641283
Human Diseases	Substance dependence	hsa05034	Alcoholism	31/1759	191/9376	0.865127437352851	H3-3B/H3-3A/TH/H2AZ1/MACROH2A1/H2AJ/H2AZ2/PPP1CB/GNB2/H2AC6/CALM2/CALM1/PPP1CA/H4C3/CREB3/GNB1/KRAS/HDAC2/HDAC1/GNB5/SHC3/HDAC11/H2AX/ADORA2B/H2BC5/H2AC20/CAMKK1/GNAS/CALML5/H2BC21/MACROH2A2	-0.90495564370422
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1759	30/9376	0.710706841008149	PLAAT2/PLAAT3/PLB1/PLA2G4A	-0.762627537464577
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/1759	116/9376	0.827115720138794	CD99/EZR/RAP1A/ACTG1/MYL12B/CTNNA1/ACTB/RAC1/CLDN3/RHOA/CLDN4/MYL12A/PTPN11/MYL5/CLDN9/MYL11/CLDN1/OCLN	-0.900338012698832
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/1759	62/9376	0.77375341561371	CRYAB/SOD1/KRAS/HDAC2/HDAC1/AKT1/AKT1S1/ATG5/MTOR	-0.858887613387207
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1759	62/9376	0.77375341561371	PSENEN/SNW1/CIR1/DVL1/RFNG/KAT2B/HDAC2/HDAC1/NUMBL	-0.858887613387207
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1759	37/9376	0.720310987508259	ADSS2/GLUD1/NIT2/ASNS/GOT1	-0.819129675788161
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1759	56/9376	0.761471615365873	CCND1/CUL3/KIF3A/FBXW11/SPOPL/SMURF1/BTRC/IQCE	-0.860305510144539
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1759	50/9376	0.746242183058556	CKB/SMS/P4HA2/SAT2/SMOX/GOT1/ALDH18A1	-0.864536445555544
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1759	93/9376	0.802410949525329	KCNN4/VAMP2/ATP2B4/CALM2/GNAQ/CALM1/KCNMA1/ATP1A4/ITPR3/GUCY1A1/CST3/ADRA1B/GNAS/CALML5	-0.920209586654743
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1759	24/9376	0.666287663445139	B3GAT3/EXT1/EXTL2	-0.78659686955429
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1759	105/9376	0.812236389723598	RRAS/PPP3CA/CALM2/CALM1/PPP3CC/ITPR3/PPP3CB/KRAS/RHOA/RRAS2/AKT1/PTPN11/NFATC3/ARHGEF12/SRC/CALML5	-0.92975680632872
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1759	63/9376	0.761471615365873	PLAAT2/PLAAT3/PTGES3/PLB1/PLA2G4A/PTGES2/PTGES/PTGR3/CBR3	-0.912834657279323
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/1759	63/9376	0.761471615365873	WNT2/WNT5A/DVL1/WNT11/GADD45A/FZD6/WNT7A/WNT2B/BMP2	-0.912834657279323
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	34/1759	212/9376	0.854859643665462	THBS1/RRAS/VEGFB/RAP1A/RALB/ACTG1/PFN2/RALA/CALM2/GNAQ/CALM1/ACTB/MAP2K2/MET/RAC1/PRKCZ/KRAS/RHOA/AKT1/PFN1/PARD6B/EFNA5/CRK/ADORA2B/NGF/GNAS/PRKCI/SRC/PFN4/EFNA3/PDGFD/EPHA2/CALML5/PDGFA	-1.0271648643738
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1759	70/9376	0.761471615365873	CCND1/CAV1/CD40/ACTG1/SGCE/ACTB/CD55/RAC1/FYN/CXADR	-0.962574036085448
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1759	89/9376	0.778583337059489	THBS1/ITGB6/LAMB3/ITGA6/ITGB4/ITGAV/SDC1/LAMC2/COL4A5/ITGA2/THBS3/COL9A3/COL4A6	-1.00854240158824
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1759	39/9376	0.683371962507835	ATIC/DLD/AHCYL1/AHCY/ST20-MTHFS	-0.952148249605565
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/1759	71/9376	0.750746663036777	CCND1/TH/MAP2K2/SOCS6/KRAS/AKT1/SOCS4/SOCS5/SHC3/SRC	-1.01306788249747
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1759	157/9376	0.814823129818259	THBS1/ITGAV/GAS6/UQCRFS1/MAP2K2/SLC2A1/RAB14/MFGE8/GULP1/NR1H2/RAC1/PBX1/P2RY2/RAB5B/VPS41/PTPN11/NFATC3/DUSP4/PANX1/CRK/TMEM30B/CD24/ATP11B/SLC66A1	-1.12440103920401
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1759	19/9376	0.561084348164328	HYAL3/HYAL1	-0.920271842258351
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/1759	122/9376	0.786437897836886	PPP3CA/PPP2CB/MAP2K2/PPP2R1A/PPP2R2A/PPP3CC/PPP3CB/KRAS/RHOA/PPP2R3A/AKT1/FYN/PTPN11/NFATC3/PPP2R2B/PPP2R5B/PAK4/PPP2R1B	-1.14094821961384
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1759	73/9376	0.730178261309742	CCND1/CDK6/BAD/MAP2K2/MET/KRAS/AKT1/GADD45A/PDGFD/PDGFA	-1.11212457139385
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	14/1759	98/9376	0.761471615365873	CALM2/PLCD1/CDIPT/CALM1/BPNT2/ITPR3/PIP4P1/CDS1/DGKA/PI4K2B/INPP4B/DGKB/CALML5/INPP1	-1.14065025246025
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/1759	86/9376	0.743762973148062	BAD/AREG/MAP2K2/KRAS/AKT1/MAP2K4/SHC3/CRK/MTOR/SRC/NRG4/PAK4	-1.1471225978506
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1759	41/9376	0.650036744824526	CCND1/THBS1/MAP2K2/KRAS/SRC	-1.07915491933823
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	28/1759	183/9376	0.8155652273864	REXO2/IMP3/NHP2/EIF6/NOP10/SNU13/POP7/RAN/SBDS/POP5/POP4/GAR1/IMP4/XRN2/RRP7A/EMG1/MPHOSPH10/RPP30/NXT2/RPP25L/NOB1/TBL3/WDR75/RPP40/NVL/PWP2/EFL1/WDR3	-1.21078295804373
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1759	12/9376	0.444191775630093	NECTIN4	-0.925787834278264
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1759	49/9376	0.652689956027891	TH/RGS9/CREB3/GPSM1/GNAS/CDK5R1	-1.17130763656256
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1759	76/9376	0.70135543520541	SCP2/ACSL3/SLC27A6/ACAA1/ACOX1/FABP5/SCD5/SLC27A4/PPARA/SLC27A5	-1.25616450395589
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1759	36/9376	0.592255700840124	DCXR/SORD/FGGY/RPE	-1.17785624823849
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1759	36/9376	0.592255700840124	PGM1/GYG1/ENPP1/G6PC3	-1.17785624823849
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1759	50/9376	0.639636156907334	THBS1/CD40/SDC1/CD81/MET/THBS3	-1.22773627141489
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1759	70/9376	0.685324453829286	GSTO2/GSTP1/GSTK1/MGST2/MGST3/HSD11B1L/GSTO1/MGST1/GSTA4	-1.26986358876972
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1759	29/9376	0.551410480092529	YAP1/WWTR1/NF2	-1.16262211841267
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1759	13/9376	0.410023177504701	XRCC6	-1.02288237417521
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/1759	103/9376	0.724506973843258	GNAQ/PPP2CB/PPP2R1A/PPP2R2A/SMAD2/AKT1/MAP2K4/GNA11/FADD/IRAK4/PPP2R2B/GNAS/PPP2R1B/TRAF6	-1.3509698976548
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1759	22/9376	0.484572846141919	ALDH3B1/CARNMT1	-1.16307181684783
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/1759	91/9376	0.702896875722345	DAPP1/PPP3CA/MAP2K2/CD81/PPP3CC/RAC1/PPP3CB/BLNK/KRAS/AKT1/NFATC3/IFITM1	-1.36855905042308
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1759	30/9376	0.533030130756111	ATIC/FOLR3/ABCC2	-1.23101452759086
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/1759	154/9376	0.761471615365873	PPP1CB/ATP2B4/CALM2/GNAQ/CALM1/PPP2CB/PPP1CA/PPP2R1A/CREB3/PPP2R2A/ATP1A4/TPM4/TPM3/PPP2R3A/AKT1/ADRA1B/PPP2R2B/GNAS/PPP2R5B/PPP2R1B/CALML5/CACNA2D3	-1.43421562191438
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/1759	59/9376	0.632408629710641	CCND1/BAD/CTNNA1/MAP2K2/KRAS/AKT1/GADD45A	-1.36106806880445
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1759	38/9376	0.561084348164328	CD40/BLNK/RFXANK/UNG	-1.30278428684582
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1759	23/9376	0.463504461527053	B4GALT2/RXYLT1	-1.23788740921026
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1759	99/9376	0.699938555538328	PPP1CB/CALM2/GNAQ/CALM1/PPP1CA/ITPR3/PLA2G4A/P2RY2/NGF/GNAS/SRC/TRPV3/CALML5	-1.44228336577544
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1759	99/9376	0.699938555538328	ITGB6/EDN1/ITGA6/ITGB4/ACTG1/SGCE/ITGAV/ACTB/ITGA2/TPM4/TPM3/LMNA/CACNA2D3	-1.44228336577544
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1759	73/9376	0.657160435178767	GSTO2/GSTP1/GSTK1/MGST2/MGST3/GSTO1/MGST1/ALDH3B1/GSTA4	-1.41308222952843
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1759	73/9376	0.657160435178767	CCND1/CDK6/BAD/KIF5B/MAP2K2/MET/KRAS/AKT1/GADD45A	-1.41308222952843
NA	NA	hsa04981	Folate transport and metabolism	3/1759	31/9376	0.51583561040914	FOLR3/ST20-MTHFS/ABCC2	-1.29750971419015
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1759	93/9376	0.687780813878853	CALM2/GNAQ/CALM1/MAP2K2/ITPR3/PLA2G4A/KRAS/MAP2K4/GNA11/GNAS/SRC/CALML5	-1.45406381333388
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/1759	224/9376	0.785267603346057	CCND1/ANAPC16/VDAC2/VDAC1/FDPS/CD40/ANAPC11/CDC26/ANAPC13/PPP3CA/RANBP1/RAN/CCND3/TSPO/MAP2K2/SLC2A1/CREB3/ANAPC5/PPP3CC/ANAPC15/SLC25A4/KAT2B/PPP3CB/KRAS/CDC16/SMAD2/CDC27/BCL2L1/AKT1/MAP2K4/NFATC3/TBPL1/CDKN2B	-1.56311220782559
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/1759	32/9376	0.499715747583854	BOK/BCL2L1/FADD	-1.3622348514844
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/1759	101/9376	0.686078386121728	CCND1/EDN1/VEGFB/F3/PLCD1/DIAPH1/RAC1/COL4A5/PRKCZ/KRAS/SMAD2/AKT1/COL4A6	-1.52423358377857
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	28/1759	195/9376	0.765376598008775	H3-3B/H3-3A/H2AZ1/MACROH2A1/H2AJ/H2AZ2/VDAC2/VDAC1/ACTG1/H2AC6/ACTB/MAP2K2/H4C3/SLC25A4/RAC1/HDAC2/HDAC1/AKT1/HMGB1/HDAC11/H2AX/H2BC5/H2AC20/CLCN5/MTOR/SRC/H2BC21/MACROH2A2	-1.5910001470905
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/1759	140/9376	0.72339803459758	CCND1/RRAS/GNB2/MAP1LC3A/CALM2/GNAQ/CALM1/MAP2K2/GNB1/ITPR3/KRAS/MYLK/SMAD2/RRAS2/AKT1/GNB5/RPS6/MTOR/CALML5	-1.58454251955044
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1759	102/9376	0.67935212743426	RAP1A/PRSS3/ATP2B4/RAB11A/GNAQ/KCNMA1/RAB27B/ATP1A4/RAC1/ITPR3/RHOA/GNAS/SLC26A3	-1.56466541468804
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/1759	196/9376	0.761471615365873	CCND1/CDK6/GNB2/PPP3CA/MAP1LC3A/CALM2/CALM1/MAP2K2/IFNAR1/TRADD/PPP3CC/GNB1/RAC1/ITPR3/PPP3CB/KRAS/RPS27A/AKT1/MAP2K4/GNB5/NFATC3/FADD/ATG14/UBA52/MTOR/SRC/CALML5/TRAF2	-1.62171055093167
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/1759	83/9376	0.642204976814592	UBE2D2/USP16/YAF2/YY1/HDAC2/HDAC1/UBE2D4/L3MBTL4/CBX6/PCGF6	-1.57333771397192
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/1759	90/9376	0.651481270924136	PPP3CA/MAP2K2/PPP3CC/PPP3CB/KRAS/AKT1/PTPN11/NFATC3/BATF/MTOR/TRAF6	-1.59646579063896
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/1759	56/9376	0.571103711524405	BNIP3/SAR1B/EEF1A1/RAB1B/ARF1/HBS1L	-1.54690956727045
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1759	110/9376	0.678401984598687	ANAPC16/ANAPC11/CDC26/ANAPC13/ANAPC5/ANAPC15/KRAS/MAD2L2/CDC16/KIF22/CDC27/AKT1/FZR1/RPS6KA2	-1.63038486394387
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/1759	130/9376	0.697039401757992	EDN1/VEGFB/GNB2/MAP2K2/CREB3/GNB1/COL4A5/PRKCZ/KRAS/SMAD2/AKT1/MAP2K4/GNB5/SHC3/COL4A6/GNAS/SRC	-1.67150415860287
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/1759	143/9376	0.708221852053575	H3-3B/H3-3A/H2AZ1/MACROH2A1/H2AJ/H2AZ2/CD40/SSB/H2AC6/SNRPD1/H4C3/SNRPB/RO60/H2AX/H2BC5/H2AC20/H2BC21/TRIM21/MACROH2A2	-1.68956904600975
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1759	105/9376	0.659942066650424	ITGB6/ITGA6/ITGB4/ACTG1/SGCE/ITGAV/ACTB/ITGA2/TPM4/TPM3/LMNA/GNAS/CACNA2D3	-1.68387888160235
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1759	17/9376	0.313547135738889	GGT6	-1.36127866715084
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/1759	99/9376	0.646097128189226	KRT14/KRT17/KRT24/DSG1/KRT19/KRT16/KRT10/KRT18/KRT13/KRT15/KRT27/KRT9	-1.70107901076254
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1759	65/9376	0.574032448506582	AGPAT2/PLPP2/MBOAT2/PLPP5/DGKA/AGPAT3/DGKB	-1.65600488160551
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1759	65/9376	0.574032448506582	KCNN4/GNAQ/MAP2K2/ITPR3/KRAS/AKT1/GNA11	-1.65600488160551
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1759	43/9376	0.495841982098708	AGPAT2/PLPP2/ACAT2/SLC27A4	-1.59227051615865
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1759	66/9376	0.565334987165573	SULT2B1/COMT/CYP7B1/HSD11B1L/HSD17B12/SRD5A1/HSD17B7	-1.70285783404325
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	54/1759	362/9376	0.795127819359945	IGF2/CCND1/THBS1/ITGB6/LAMB3/CDK6/VEGFB/ITGA6/BAD/ITGB4/EIF4E2/GNB2/AREG/ITGAV/YWHAH/CCND3/YWHAQ/PPP2CB/MAP2K2/PPP2R1A/CREB3/PPP2R2A/IFNAR1/MET/LAMC2/YWHAB/GNB1/RAC1/COL4A5/ITGA2/KRAS/MLST8/YWHAZ/BCL2L1/THBS3/PPP2R3A/AKT1/GNB5/RPS6/COL9A3/EFNA5/PPP2R2B/G6PC3/COL4A6/NGF/THEM4/MTOR/EFNA3/PDGFD/PPP2R5B/EPHA2/PPP2R1B/PDGFA/C8orf44-SGK3	-1.91031540801194
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/1759	155/9376	0.687780813878853	CCND1/WNT2/CDK6/WNT5A/RAP1A/GNAQ/MAP2K2/DVL1/CREB3/ITPR3/FH/PBX1/AIP/WNT11/FZD6/CDKN2B/GNA11/WNT7A/WNT2B/GNAS	-1.88348864146845
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1759	68/9376	0.548707487543056	CCND1/JUP/BAD/MAP2K2/KRAS/AKT1/MTOR	-1.7947789911226
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1759	103/9376	0.621005977579936	KCNN4/PRSS3/SLC1A5/COL7A1/COL17A1/COL12A1/ATP1A4/COL4A5/COL9A3/SLC36A4/COL4A6/SLC9A3	-1.85852078661806
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1759	150/9376	0.675171498957741	CCND1/JUP/WNT2/WNT5A/CTNNA1/MAP2K2/DVL1/MET/KRAS/SMAD2/AKT1/WNT11/GADD45A/FZD6/CDKN2B/WNT7A/SHC3/WNT2B/MTOR	-1.92716816338608
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/1759	97/9376	0.604467158589405	GNB2/CALM2/GNAQ/CALM1/GNB1/ITPR3/GUCY1A1/GNB5/PER3/GNAS/CALML5	-1.88167410815
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1759	69/9376	0.540755205114896	MAP2K2/RAC1/PLA2G4A/KRAS/AKT1/FYN/MAP2K4	-1.83988429025019
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/1759	144/9376	0.666287663445139	HAND1/WNT2/ID4/WNT5A/MAP2K2/DVL1/KRAS/SMAD2/AKT1/WNT11/FZD6/BMPR1A/WNT7A/ACVR2A/WNT2B/MEIS1/SMAD1/PCGF6	-1.93924281066563
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	11/1759	98/9376	0.5982991263589	ATP2B4/CALM2/CAMK1D/GNAQ/CALM1/CREB3/ATP1A4/ITPR3/GNA11/GNAS/CALML5	-1.92094623721636
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1759	47/9376	0.453642664473286	PKM/PRKCZ/SOCS4/MTOR	-1.80440798772215
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/1759	106/9376	0.603430336705032	CCND1/GSTP1/SPINT1/BAD/MAP2K2/CREB3/FOLR3/KRAS/AKT1/MTOR/PDGFD/PDGFA	-1.97314560403416
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1759	78/9376	0.546697570006268	TPI1/PLCD1/CDIPT/INPP5K/PI4K2B/INPP4B/PIP5KL1/INPP1	-1.93182222294249
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/1759	78/9376	0.546697570006268	CALM2/CALM1/CFL2/RHOA/CFL1/IRAK4/CALML5/TRAF6	-1.93182222294249
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1759	21/9376	0.253823871788624	B3GAT3	-1.64496129038985
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/1759	180/9376	0.681094055966142	BAD/PPP1CB/PPP1CA/SRPK1/SRSF9/IFNAR1/EIF2S1/ALYREF/TRADD/SRSF8/SRSF4/BCL2L1/AKT1/PTPN11/EIF2B3/EIF2B2/FADD/IRAK4/MTOR/SRC/TRAF2/TRAF6/RNASEL	-2.07599338554189
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/1759	65/9376	0.492027813005641	GNAQ/CREB3/ITPR3/PBX1/GNA11/GNAS	-1.97480868773518
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/1759	122/9376	0.6116739205398	GNAQ/MAP2K2/CREB3/ITPR3/KRAS/AKT1/MAP2K4/GNA11/SSTR1/IGFBP3/SHC3/CRK/MTOR/GNAS	-2.07461878536548
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/1759	227/9376	0.704445106726138	CCND1/CDK6/GNB2/ITGAV/PPP3CA/CALM2/GNAQ/CALM1/MAP2K2/CREB3/TRADD/PPP3CC/GNB1/RAC1/ITPR3/PPP3CB/KRAS/RHOA/AKT1/GNB5/NFATC3/ARHGEF12/GNA11/FADD/CRK/MTOR/GNAS/SRC/CALML5/TRAF2	-2.16616158112716
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1759	59/9376	0.451720449793315	PLAAT2/PLAAT3/AKT1/CIDEC/GNAS	-2.03009604925535
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1759	23/9376	0.231752230763527	ATP6AP2	-1.77262283186657
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1759	75/9376	0.497494788705704	GNAQ/CREB3/ATP1A4/ITPR3/GNAS/DUOX1/TTF2	-2.09958257441028
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/1759	90/9376	0.533030130756111	ADIPOR1/EIF4E2/APPL1/CREB3/KRAS/AKT1/AKT1S1/ATG5/MTOR	-2.13905698406452
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1759	52/9376	0.410023177504701	PLA2G4A/HSD17B7/GNAS/ACOT4	-2.05003874926939
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/1759	105/9376	0.558412517934974	CD40/UBE2I/TRADD/PPP1R13L/BLNK/BCL2L1/GADD45A/IRAK4/TRAF2/EDARADD/TRAF6	-2.18662693178477
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1759	99/9376	0.538414273491022	CCND1/BAD/MAP2K2/KRAS/AKT1/BIK/SHC3/MTOR/GNAS/SRC	-2.21867030073672
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1759	45/9376	0.355353420504074	ABCB8/ABCC2/ABCA2	-2.08300553967364
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1759	254/9376	0.69251946121857	VEGFB/VDAC2/VDAC1/ORAI3/PPP3CA/ATP2B4/CALM2/CAMK1D/PLCD1/GNAQ/CALM1/AVPR1A/MET/PPP3CC/SLC25A4/ASPH/ITPR3/PPP3CB/MYLK/STIM1/NFATC3/ADRA1B/GNA11/SLN/TNNC2/ADORA2B/NGF/GNAS/PDGFD/CALML5/NTRK3/PHKG1/PDGFA	-2.38734969214453
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1759	115/9376	0.556205353832464	GNB2/GNAQ/CREB3/GNB1/ACHE/ITPR3/KRAS/AKT1/FYN/GNB5/GNA11/SLC18A3	-2.30106357054359
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/1759	136/9376	0.587900879510417	CCND1/CDK6/BAD/RAB9A/CCND3/EIF3H/IFNAR1/EIF2S1/TRADD/BCL2L1/AKT1/FADD/IRAK4/RACK1/TRAF6	-2.32627865799904
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1759	116/9376	0.551410480092529	GNB2/SLC38A1/PPP3CA/GNAQ/PPP3CC/GNB1/ITPR3/PPP3CB/SLC1A6/PLA2G4A/GNB5/GNAS	-2.33614182385615
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1759	72/9376	0.444191775630093	PIN1/TRADD/ATG5/FADD/TRAF2/TRAF6	-2.27500809487239
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/1759	103/9376	0.517504981316613	LAMB3/GNAQ/LAMC2/COL4A5/RAB5B/PRDX1/GNA11/COL4A6/GNAS/SERPINB10	-2.36607167558131
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/1759	160/9376	0.599658897100625	ALCAM/CD99/ITGA6/SLITRK6/CD40/ITGAV/SDC1/CLDN3/CLDN4/VTCN1/NECTIN3/CADM1/CLDN9/NRXN3/CLDN1/CXADR/OCLN/CDH2	-2.45440100272903
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/1759	187/9376	0.627094271477778	VDAC2/VDAC1/NEK7/GABARAPL2/TXN/SUGT1/MAP1LC3A/TXN2/IFNAR1/SHARPIN/ITPR3/TRIP6/RHOA/GBP2/BCL2L1/ATG5/FADD/PANX1/IRAK4/TRAF2/TRAF6/RNASEL	-2.47521149142352
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1759	48/9376	0.33314383172257	ATP1A4/AKT1/G6PC3	-2.2257946939645
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/1759	89/9376	0.479128207421224	GABARAPL2/GNB2/TRAK2/SLC38A1/GABRP/GNB1/GNB5/SRC	-2.37254631891959
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/1759	216/9376	0.641610342576801	MIB2/BAD/CD40/RAP1A/PPP3CA/CALM2/CALM1/ERO1A/EIF2S1/PPP3CC/RAC1/PPP3CB/KRAS/RHOA/BCL2L1/AKT1/MAP2K4/NFATC3/CASP6/IRAK4/MIB1/SRC/CALML5/TRAF2/TRAF6/VLDLR	-2.56071465508557
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/1759	300/9376	0.692939169982945	IGF2/RRAS/VEGFB/RAP1A/AREG/PPP3CA/MAP3K13/MAP2K2/MAPKAPK3/MET/TRADD/PPP3CC/RAC1/PPP3CB/PLA2G4A/KRAS/ECSIT/RRAS2/AKT1/GADD45A/MAP2K4/NFATC3/DUSP4/EFNA5/IRAK4/CRK/RASGRF1/MAPKAPK5/NGF/RPS6KA2/EFNA3/PDGFD/MECOM/EPHA2/TRAF2/TRAF6/PDGFA/CACNA2D3/MAP2K5	-2.59755279561749
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/1759	109/9376	0.489018468583588	CD40/MAP2K2/IFNAR1/TOLLIP/RAC1/AKT1/MAP2K4/FADD/IRAK4/TRAF6	-2.57854937085801
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1759	94/9376	0.453642664473286	IL17RC/ANAPC5/TRADD/IL17RE/FADD/TRAF3IP2/TRAF2/TRAF6	-2.5582707378209
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/1759	148/9376	0.540233240631194	CCND1/WNT2/CDK6/WNT5A/MAP2K2/DVL1/KRAS/AKT1/WNT11/GADD45A/FZD6/WNT7A/SHC3/WNT2B/MTOR	-2.70920091716781
Human Diseases	Immune disease	hsa05310	Asthma	1/1759	32/9376	0.166571915861285	CD40	-2.26935942304105
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1759	90/9376	0.414578990588087	SLC2A1/ATP1A4/HMGCR/ABCC2/GNAS/SLC27A5/SLC9A3	-2.68164817749008
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1759	173/9376	0.554597823908093	CDK6/VDAC1/FDPS/ACTG1/PRSS3/CCND3/RAB11A/ACTB/MAP2K2/IFNAR1/EIF2S1/TRADD/SLC25A4/AKT1/FADD/NXT2/IRAK4/RNASEL	-2.84143192190761
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1759	91/9376	0.410023177504701	GNB2/GABRP/GNB1/GNB5/GNAS/GRK4/PDE10A	-2.71763591153363
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/1759	115/9376	0.463504461527053	PTHLH/GNAQ/CREB3/NACA/OXSR1/ITPR3/RHOA/GNA11/GNAS/MMP24	-2.78171525952394
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/1759	181/9376	0.559534391401443	BAD/PPP3CA/ATP6AP1/CALM2/CALM1/LAMP1/TRADD/PPP3CC/PPP3CB/RHOA/RAB5B/AKT1/RFXANK/ARHGEF12/FADD/IRAK4/SRC/CALML5/TRAF6	-2.87542474148339
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/1759	168/9376	0.539375727550827	CCND1/CCND3/CLCF1/IFNAR1/SOCS6/STAM/BCL2L1/AKT1/PTPN11/SOCS4/SOCS5/PIAS3/LEPR/IL22RA1/MTOR/PDGFA/IFNLR1	-2.89497878132443
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/1759	133/9376	0.48092944128371	CCND1/BNIP3/GABARAPL2/MAP2K2/FBXO25/KRAS/AKT1/GADD45A/SETD7/CDKN2B/G6PC3/C8orf44-SGK3	-2.89715893528597
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1759	68/9376	0.313547135738889	CYP26B1/PNPLA4/DHRS4L2/ALDH1A3	-2.73000580591134
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	25/1759	226/9376	0.589635100393929	RRAS/EDN1/BAD/PPP1CB/RAP1A/ATP2B4/CALM2/CALM1/PPP1CA/MAP2K2/CREB3/SOX9/ATP1A4/RAC1/ACOX1/RHOA/RRAS2/AKT1/SSTR1/EDN2/CNGA1/GNAS/PPARA/PDE10A/CALML5	-3.00082354814604
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/1759	163/9376	0.523219760251398	BAD/ATP6AP1/YWHAQ/MAP2K2/CREB3/IFNAR1/YWHAB/KRAS/YWHAZ/AKT1/MAP2K4/NFATC3/FADD/IRAK4/SRC/TRAF6	-2.95078858294168
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/1759	95/9376	0.392759043715029	ATP6V1D/ATP6AP1/ATP6V1F/ATP6V1G1/ATP6V1E1/ATP6V0E1/ATP6V0E2	-2.85859119694958
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/1759	142/9376	0.487985330973905	PPP3CA/IFNAR1/PPP3CC/RAC1/ITPR3/PPP3CB/BLNK/AKT1/FYN/FHL2/TMEM64/TRAF2/TRAF6	-2.9543246679001
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/1759	37/9376	0.144062197501652	GNAQ	-2.50679870620948
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/1759	112/9376	0.428327783643304	LAMB3/ITGA6/BAD/CD40/LAMC2/BCL2L1/AKT1/IRAK4/TRAF6	-2.92471400009542
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/1759	201/9376	0.556897151536236	H3-3B/H3-3A/JUP/SPINT1/CD40/MET/ETV1/PBX1/MLF1/HDAC2/SUPT3H/HDAC1/BCL2L1/GADD45A/IGFBP3/PRCC/MEIS1/PBX3/CDK14/SMAD1/PDGFA	-3.05158951663742
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/1759	50/9376	0.213212052302445	CD40/CCL28	-2.68053557485225
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/1759	88/9376	0.36342963460644	CLU/SERPINB2/CD59/F3/CD55/F12	-2.8830570058378
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1759	39/9376	0.136674392501567	CD40	-2.59615027314072
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/1759	115/9376	0.417154015374348	GNB2/GNAQ/APP/GNB1/ITPR3/PLA2G4A/KRAS/GNB5/GNAS	-3.02204110401412
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1759	41/9376	0.130007348964905	GABRP	-2.68272978739406
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/1759	217/9376	0.540399210904813	CCND1/GSTO2/BAD/CCND3/MAP2K2/PTGES3/CREB3/MGST2/MGST3/KPNA4/GSTO1/AIP/KRAS/AKT1/MGST1/KPNA3/GSTA4/RPS6KA2/MTOR/GNAS/SRC/PPARA	-3.29164645740832
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/1759	144/9376	0.444191775630093	CCND1/ADIPOR1/IL17RC/TRADD/ACOX1/AKT1/MAP2K4/SCD5/FADD/IRAK4/PPARA/TRAF6	-3.22986891748001
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1759	133/9376	0.400774534403091	PPP3CA/MAP2K2/IFNAR1/PPP3CC/RAC1/PPP3CB/KRAS/FYN/PTPN11/SHC3	-3.34453839223398
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1759	100/9376	0.319818078453667	CD9/CD59/ITGA6/CD55/ITGA2/CD24	-3.2860282659207
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/1759	119/9376	0.358339583701587	EDN1/CREB3/TRADD/AKT1/MAP2K4/FADD/BAG4/TRAF2	-3.38508967136152
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/1759	193/9376	0.469508405329217	BAD/RAP1A/GNB2/GNAQ/GNB1/RAC1/PRKCZ/KRAS/RHOA/AKT1/GNB5/CCL27/SHC3/CRK/SRC/GRK4/CCL28	-3.57842113013095
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/1759	78/9376	0.205011588752351	EEF1A1/IRAK4/TRAF6	-3.38797274890229
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1759	54/9376	0.098709283473354	CD40	-3.19178631636536
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/1759	109/9376	0.293411081150153	PPP3CA/PPP3CC/PPP3CB/SMAD2/NFATC3/MTOR	-3.56563652526757
NA	NA	hsa04081	Hormone signaling	19/1759	219/9376	0.462446232162836	IGF2/ADIPOR1/PTHLH/GNB2/ITGAV/APPL1/GNAQ/AVPR1A/GNB1/RHOA/GNB5/ADRA1B/GNA11/SSTR1/BMPR1A/LEPR/GNAS/SRC/SMAD1	-3.8680665787827
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/1759	93/9376	0.229260271292951	PPP3CA/PPP3CC/PPP3CB/NFATC3	-3.58948072005043
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1759	86/9376	0.185940743287016	ITPR3/TAS2R20/SCNN1A	-3.64438262821603
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/1759	66/9376	0.0807621410236532	SMAD2	-3.60123622395916
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/1759	82/9376	0.130007348964905	RFXANK/PSME3	-3.80231205393256
NA	NA	hsa04082	Neuroactive ligand signaling	14/1759	199/9376	0.374996071888722	GNB2/GABRP/GNAQ/GNB1/ACHE/SLC1A6/P2RY2/GNB5/ADRA1B/GNA11/SLC18A3/ADORA2B/GNAS/SLC6A9	-4.28238293111543
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1759	100/9376	0.159909039226833	CCL27/IL22RA1/CCL28	-4.05856515087789
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	23/1759	323/9376	0.379557059052339	CCND1/THBS1/CDK6/EZR/SERPINB5/RDX/MAP2K2/UBE2I/MET/KRAS/RHOA/HDAC2/HDAC1/EFNA5/SPRY2/CRK/CCNG1/BCL2L2/MTOR/VIM/EFNA3/PAK4/PDGFA	-5.45297402412151
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/1759	298/9376	0.321964508510403	TNFRSF12A/IL17RC/CD40/IL36RN/CLCF1/IFNAR1/IL17RE/TNFRSF21/CCL27/BMPR1A/ACVR2A/IL1RL2/LEPR/IL22RA1/NGF/BMP2/CCL28/IFNLR1	-5.71599776616786
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/1759	370/9376	0.259311955502973	EDN1/LYPD6B/PGRMC2/PRSS3/GABRP/PGRMC1/TSPO/AVPR1A/P2RY2/NR3C1/ADRA1B/SSTR1/EDN2/ADORA2B/NPB/LEPR/GAL/PAQR6	-6.98548887889549
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/1759	449/9376	0.0593574755853131	CALM2/CALM1/GNB1/OR2T2/CALML5	-9.81570712303311