category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	95/1572	222/9376	2.55232331568209	RPL39/RPL41/FAU/RPL30/RPS21/RPL28/RPS4X/RPS23/RPL37A/RPL36/RPL19/RPL12/RPL37/RPS15A/RPL22/RPS24/RPS19/RPL35A/RPL32/RPS27A/RPS27/RPL34/RPS15/RPL13/RPL36AL/RPL14/RPS28/RPL5/RPL21/RPLP2/RPL10/RPS8/RPLP1/UBA52/RPL6/RPL29/RPS3A/RPS14/RPS12/RPL11/RPL8/RPS7/RPL24/MRPL23/RPS29/RPL18/RPS13/RPS2/RPL35/MRPL36/RPL38/RPL9/RPS5/MRPL33/MRPS21/MRPL40/MRPL54/RSL24D1/MRPL16/RPSA/RPL7/MRPL41/MRPL13/MRPS23/RPL15/RPL23/MRPS18C/MRPL50/MRPL51/MRPS33/MRPS9/MRPL11/MRPL47/MRPS14/MRPL37/MRPS26/MRPS2/MRPL19/MRPL22/MRPS30/MRPS18A/MRPL21/MRPL14/MRPL20/MRPS34/MRPL34/MRPS15/MRPL24/MRPL9/MRPS22/MRPL1/RPL26L1/MRPL44/MRPS7/MRPL18	10.5052524287272
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	63/1572	138/9376	2.72286757384666	COX7A1/ATP5F1E/MT-ND3/MT-CO3/COX7C/MT-CO1/NDUFA4L2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/ATP5ME/NDUFC1/NDUFB2/NDUFS5/ATP6V0C/COX6B1/UQCRQ/COX4I1/ATP6V1B2/COX7A2/COX7B/COX6A1/NDUFB6/ATP5PD/UQCRH/NDUFB5/COX11/COX7A2L/NDUFS8/COX17/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/ATP6V1F/PPA2/ATP5F1D/ATP5PO/NDUFA2/NDUFA1/LHPP/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ATP5MF/ATP5MC1/NDUFV2/NDUFS7/NDUFB4/UQCRHL/ATP5PF/NDUFB8/ATP6AP1/COX5A/PPA1/COX8A/NDUFB11/NDUFB10/NDUFB9	9.15072997526383
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	95/1572	275/9376	2.06042100393245	COX7A1/KLC3/ATP5F1E/CAV1/FYN/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/MT-CO1/NDUFA4L2/CYBA/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/NDUFC1/NDUFB2/NDUFS5/NCF1/COX6B1/HSPA1A/UQCRQ/PRKACB/COX4I1/NCAM2/CAV2/COX7A2/VDAC2/COX7B/COX6A1/NDUFB6/PRKACA/PPIF/ATP5PD/PPP3R1/UQCRH/NDUFB5/VDAC1/KIF5B/COX7A2L/NDUFS8/GRIN2B/EIF2AK3/RAC2/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/PRNP/VDAC3/PIK3R1/ATP5F1D/ATP5PO/NDUFA2/PPP3CC/NDUFA1/HSPA8/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ATP5MC1/C5/PSMA7/CASP3/ITPR1/MAPK13/PSMD6/NDUFV2/NDUFS7/NCAM1/PSMB1/PRKCD/PSMC5/PSMB6/NDUFB4/PSMD12/ATF2/UQCRHL/PSMC6/ATP5PF/NDUFB8/C7/PSMD9/COX5A/COX8A/IL6/NDUFB11/PSMC1/NDUFB10/NDUFB9	8.01038499627986
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	92/1572	268/9376	2.04747256085982	COX7A1/KLC3/CAMK2D/ATP5F1E/TH/MT-ND3/MT-CO3/TUBA4A/TXN/COX7C/TUBA1A/RPS27A/MT-CO1/CALM2/NDUFA4L2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/UBA52/NDUFC1/NDUFB2/NDUFS5/COX6B1/UQCRQ/UBB/PRKACB/COX4I1/COX7A2/VDAC2/COX7B/COX6A1/NDUFB6/PRKACA/PPIF/ATP5PD/UQCRH/CALM1/NDUFB5/VDAC1/KIF5B/COX7A2L/NDUFS8/EIF2AK3/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/VDAC3/ATP5F1D/ATP5PO/PARK7/NDUFA2/ERN1/NDUFA1/UCHL1/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/BCL2L1/ATP5MC1/PRKN/PSMA7/MAOB/CASP3/ITPR1/PSMD6/NDUFV2/NDUFS7/PSMB1/NFE2L2/GNAI3/PSMC5/PSMB6/NDUFB4/PSMD12/UQCRHL/PSMC6/ATP5PF/NDUFB8/ATF6/PSMD9/COX5A/COX8A/NDUFB11/PSMC1/NDUFB10/NDUFB9/SLC39A10	7.80821602054541
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	75/1572	205/9376	2.18208899646248	COX7A1/COL3A1/CAMK2D/ATP5F1E/COL1A2/MT-ND3/MT-CO3/GAPDH/COX7C/MT-CO1/NDUFA4L2/CYBA/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/NDUFC1/NDUFB2/NDUFS5/NCF1/MPC2/COX6B1/UQCRQ/COL1A1/COX4I1/COX7A2/VDAC2/COX7B/COX6A1/PDK2/NDUFB6/PPIF/ATP5PD/UQCRH/NDUFB5/VDAC1/PARP1/COX7A2L/NDUFS8/RAC2/PPP1CB/NDUFB7/ATP5MC2/CD36/PTEN/NDUFS4/NDUFS6/VDAC3/PIK3R1/ATP5F1D/ATP5PO/NDUFA2/NDUFA1/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ATP5MC1/MAPK13/NDUFV2/NDUFS7/PRKCD/NDUFB4/TGFBR1/UQCRHL/ATP5PF/NDUFB8/PLCB2/COX5A/COX8A/NDUFB11/NDUFB10/NDUFB9	7.68019129150245
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	82/1572	235/9376	2.0811867251367	COX7A1/ATP5F1E/ACTB/MT-ND3/MT-CO3/COX7C/MT-CO1/ACSL3/NDUFA4L2/NDUFB1/NDUFA4/ACSL1/UQCRB/NDUFA3/COX6C/ATP5ME/NDUFC1/NDUFB2/ACTG1/NDUFS5/COX6B1/UQCRQ/MAP2K3/PRKACB/COX4I1/COX7A2/COX7B/COX6A1/NDUFB6/PRKACA/NDUFAF4/NDUFAF8/RPS6KA2/ATP5PD/UQCRH/NDUFAF2/NDUFB5/COX11/COX7A2L/NDUFS8/COX17/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/KRAS/COA5/ATP5F1D/ATP5PO/NDUFA2/NDUFA1/DPF3/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ATP5MF/ATP5MC1/MAPK13/NDUFV2/ADCY3/NDUFS7/ZNF516/ARID1B/NDUFB4/NDUFAF1/NDUFAF6/AKT1S1/ATF2/UQCRHL/ATP5PF/NDUFB8/COX18/COX5A/COX8A/COX14/NDUFB11/NDUFB10/NDUFB9/PRKAA2/SLC25A29	7.53340056203576
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	80/1572	227/9376	2.10198293932363	COX7A1/ATP5F1E/MGST1/MT-ND3/MT-CO3/SOD2/COX7C/MT-CO1/NDUFA4L2/CYBA/HIF1A/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/NDUFC1/NDUFB2/NDUFS5/SLC26A2/NCF1/COX6B1/UQCRQ/PTPRJ/COX4I1/COX7A2/VDAC2/COX7B/COX6A1/MET/NQO1/NDUFB6/ABL2/PPIF/ATP5PD/JUN/UQCRH/NDUFB5/VDAC1/COX7A2L/GSTO2/NDUFS8/NDUFB7/ATP5MC2/PTEN/NDUFS4/NDUFS6/KRAS/VDAC3/PIK3R1/ATP5F1D/ATP5PO/PRKD1/NDUFA2/NDUFA1/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ABL1/ATP5MC1/MAPK13/VEGFA/NDUFV2/AHR/NDUFS7/NFE2L2/PRKCD/NDUFB4/UQCRHL/ATP5PF/NDUFB8/CHUK/PRKD2/COX5A/COX8A/NDUFB11/NDUFB10/NDUFB9	7.54317640737662
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	80/1572	238/9376	2.00483246733808	RPL39/RPL41/FAU/RPL30/RPS21/RPL28/RPS4X/RPS23/RPL37A/RPL36/RPL19/RPL12/RPL37/RPS15A/RPL22/RPS24/RPS19/RPL35A/RPL32/RPS27A/RPS27/RPL34/RPS15/RPL13/RPL36AL/RPL14/RPS28/CXCL8/RPL5/RPL21/RPLP2/RPL10/RPS8/IRF9/RPLP1/UBA52/RPL6/RPL29/RPS3A/RPS14/RPS12/RPL11/RPL8/RPS7/RPL24/RPS29/RPL18/RPS13/RPS2/ADAM17/RPL35/RPL38/RPL9/NFKBIB/RPS5/CFD/MMP1/RSL24D1/JUN/STAT1/RPSA/RPL7/MX2/RPL15/RPL23/STAT3/ACE2/PIK3R1/HBEGF/OAS2/C5/MAPK13/RPL26L1/CFB/CHUK/C7/C5AR1/SYK/IL6/VWF	7.04709034960752
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	58/1572	157/9376	2.2034002690394	COX7A1/MT-CO3/COX7C/MT-CO1/NDUFA4L2/CXCL8/ADIPOR2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/NDUFC1/NDUFB2/NDUFS5/COX6B1/UQCRQ/COX4I1/COX7A2/COX7B/COX6A1/NDUFB6/BCL2L11/JUN/UQCRH/NDUFB5/COX7A2L/NDUFS8/EIF2AK3/NDUFB7/NDUFS4/NDUFS6/FAS/PIK3R1/NDUFA2/BID/ERN1/NDUFA1/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/CASP3/MAPK13/NDUFV2/NDUFS7/LEPR/NDUFB4/UQCRHL/NDUFB8/COX5A/COX8A/IL6/NDUFB11/NDUFB10/NDUFB9/PRKAA2	6.82450728429281
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	107/1572	388/9376	1.64481519372524	COX7A1/WNT5A/WNT2/KLC3/ATP5F1E/DKK1/MT-ND3/MT-CO3/TUBA4A/GAPDH/COX7C/TUBA1A/MT-CO1/CALM2/NDUFA4L2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/FZD6/NDUFC1/NDUFB2/WNT10A/DKK2/LPL/NDUFS5/COX6B1/APBB1/UQCRQ/COX4I1/BACE1/COX7A2/VDAC2/COX7B/ADAM17/COX6A1/WNT6/NDUFB6/PPIF/ATP5PD/PPP3R1/UQCRH/CALM1/NDUFB5/VDAC1/FZD1/WNT11/KIF5B/COX7A2L/NDUFS8/GRIN2B/EIF2AK3/NDUFB7/ATP5MC2/PSEN1/NDUFS4/NDUFS6/KRAS/FAS/VDAC3/PIK3R1/ATP5F1D/ATP5PO/NDUFA2/PPP3CC/BID/ERN1/NDUFA1/PTGS2/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/LRP5/ATP5MC1/PSMA7/CASP3/ITPR1/PSMD6/NDUFV2/NDUFS7/PSMB1/PSMC5/PSMB6/NDUFB4/RB1CC1/PSMD12/UQCRHL/CAPN2/PSMC6/ATP5PF/NDUFB8/CHUK/ATF6/PSMD9/PLCB2/COX5A/COX8A/IL6/NDUFB11/PSMC1/NDUFB10/CDK5R1/NDUFB9/SLC39A10	5.82200899080693
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	89/1572	308/9376	1.72347245629688	COX7A1/KLC3/ATP5F1E/MT-ND3/MT-CO3/TUBA4A/SOD2/COX7C/TUBA1A/TGM2/MT-CO1/POLR2L/NDUFA4L2/NDUFB1/NDUFA4/POLR2I/AP2S1/UQCRB/NDUFA3/COX6C/IFT57/NDUFC1/NDUFB2/GPX1/NDUFS5/COX6B1/UQCRQ/DNAH5/COX4I1/COX7A2/VDAC2/COX7B/COX6A1/NDUFB6/POLR2G/PPIF/DCTN3/ATP5PD/UQCRH/NDUFB5/VDAC1/KIF5B/COX7A2L/NDUFS8/GRIN2B/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/VDAC3/ATP5F1D/ATP5PO/ACTR10/NDUFA2/ERN1/NDUFA1/DNAH7/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/ATP5MC1/PSMA7/CASP3/DCTN2/ITPR1/PSMD6/NDUFV2/NDUFS7/AP2A1/PSMB1/PSMC5/PSMB6/NDUFB4/RB1CC1/PSMD12/UQCRHL/PSMC6/ATP5PF/NDUFB8/PSMD9/PLCB2/COX5A/COX8A/NDUFB11/PSMC1/NDUFB10/NDUFB9	5.79421869085076
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	100/1572	368/9376	1.62075450824206	COX7A1/KLC3/ATP5F1E/ACTB/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/MT-CO1/NDUFA4L2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/NDUFC1/PFN2/NDUFB2/GPX1/ACTG1/NDUFS5/COX6B1/OPTN/UQCRQ/MAP2K3/DNAH5/COX4I1/COX7A2/COX7B/MAP1LC3A/COX6A1/NDUFB6/DCTN3/ATP5PD/TANK/PPP3R1/UQCRH/NDUFB5/VDAC1/KIF5B/PFN4/COX7A2L/NDUFS8/GRIN2B/EIF2AK3/NDUFB7/ATP5MC2/NDUFS4/NDUFS6/ATP5F1D/ATP5PO/ACTR10/NDUFA2/PPP3CC/BID/ERN1/NDUFA1/DNAH7/NUP214/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/BCL2L1/ATP5MC1/PRKN/POM121C/PSMA7/CASP3/DCTN2/ANXA7/MAPK13/PSMD6/NDUFV2/NDUFS7/PSMB1/NUP37/PSMC5/VCP/PSMB6/NDUFB4/RB1CC1/PSMD12/UQCRHL/UBQLN1/PSMC6/ATP5PF/NDUFB8/ATF6/PSMD9/COX5A/COX8A/ANG/NDUFB11/PSMC1/RANBP2/NDUFB10/NDUFB9	5.45233939241328
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	122/1572	480/9376	1.51594571670908	COX7A1/WNT5A/WNT2/KLC3/CAMK2D/ATP5F1E/DKK1/MT-ND3/MT-CO3/TUBA4A/COX7C/TUBA1A/RPS27A/MT-CO1/CALM2/NDUFA4L2/NDUFB1/NDUFA4/UQCRB/NDUFA3/COX6C/FZD6/IFT57/UBA52/NDUFC1/NDUFB2/GPX1/WNT10A/DKK2/NDUFS5/COX6B1/OPTN/UQCRQ/MAP2K3/DNAH5/UBB/COX4I1/SPTBN2/COX7A2/VDAC2/COX7B/MAP1LC3A/COX6A1/WNT6/NDUFB6/PPIF/DCTN3/ATP5PD/TANK/PPP3R1/UQCRH/CALM1/NDUFB5/VDAC1/FZD1/WNT11/KIF5B/COX7A2L/NDUFS8/GRIN2B/EIF2AK3/NDUFB7/ATP5MC2/PSEN1/NDUFS4/NDUFS6/KRAS/PRNP/FAS/VDAC3/ATP5F1D/ATP5PO/PARK7/ACTR10/NDUFA2/PPP3CC/BID/ERN1/NDUFA1/DNAH7/UCHL1/PTGS2/NDUFB3/NDUFAB1/COX5B/NDUFA12/UQCR10/BCL2L1/LRP5/ATP5MC1/PRKN/PSMA7/CASP3/DCTN2/ITPR1/MAPK13/PSMD6/NDUFV2/NDUFS7/PSMB1/PSMC5/VCP/PSMB6/NDUFB4/RB1CC1/PSMD12/UQCRHL/CAPN2/PSMC6/ATP5PF/NDUFB8/ATF6/PSMD9/PLCB2/COX5A/COX8A/IL6/NDUFB11/PSMC1/NDUFB10/CDK5R1/NDUFB9	5.20811447638535
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	28/1572	70/9376	2.38575063613232	CCND1/CD40/ACTB/CAV1/FYN/ACTG1/CXADR/CD55/ABL2/SGCB/HLA-A/RAC2/PRF1/HLA-DPB1/BID/HLA-DRA/HLA-B/ABL1/CASP3/HLA-DQA2/HLA-F/HLA-DRB5/ICAM1/HLA-DMA/HLA-DMB/LAMA2/SNTA1/HLA-DPA1	5.22282965348912
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/1572	75/9376	2.14717557251908	THBS1/CCND1/CCND2/SFN/CDK6/SERPINB5/CD82/TP53I3/CDKN2A/SESN3/PERP/DDB2/CCND3/GADD45G/PTEN/FAS/GADD45B/ZMAT3/RRM2B/BID/ZNF385A/PMAIP1/BCL2L1/CASP3/CCNG1/CDKN1A/CHEK1	4.47660709752301
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	36/1572	116/9376	1.85101342458542	GAPDH/PRPS2/PFKP/ACAT2/ALDOC/ENO1/ECHS1/SDSL/TALDO1/PGK1/ME3/TPI1/TKT/ACOX1/SUCLG2/ESD/GPI/ENO2/SUCLA2/PFKM/TKFC/SUCLG1/PGAM4/PGAM1/IDH3A/DLD/IDNK/FH/MDH1/GLUD1/PGLS/MDH2/GOT1/PKM/IDH3B/ACSS1	4.13916930738133
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	55/1572	203/9376	1.61596410082854	THBS1/EMP1/CCND1/CCND2/EMP2/MYLK/LAMB3/COL1A2/ACTB/CAV1/FYN/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/MYL9/ZYX/MYL12B/ACTG1/COL9A3/COL1A1/CAV2/THBS3/MET/PDGFA/ITGA1/RAP1A/MYL5/JUN/CCND3/ITGA6/MYL11/RAC2/PPP1CB/PTEN/PIK3R1/ITGB8/PDGFD/COL6A2/CRK/VEGFA/RHOA/COL6A3/PIP5K1B/BIRC3/RAP1B/CAPN2/LAMA2/MYL12A/VWF/VTN	3.98199767906751
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	61/1572	233/9376	1.56148915025828	VIM/DCN/THBS1/COL3A1/PDLIM1/MYH14/COL1A2/ACTB/PDLIM4/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/TRIM55/TNNT1/ANK3/ITGB4/MYL9/ZYX/ACTG1/VCAN/FBLN2/ANKRD2/COL9A3/COL5A2/COL1A1/THBS3/SPTBN2/ENO1/TNNC2/ITGA1/ANK2/TPM2/LMNA/MYL5/TMOD3/SDC3/SGCB/NID2/ITGA6/MYL11/ENO2/MYH15/ITGB8/MYL4/TNNC1/DIAPH3/PLEC/COL6A2/CAPZA2/SPTBN1/FMNL3/ATP1B1/COL6A3/NEBL/SDC2/LAMA2/SDC1/SNTA1/FBN2	3.89518642558272
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	55/1572	205/9376	1.60019859740582	VIM/CCND1/CCND2/CDK6/CD40/IRF9/CD44/MAP2K3/SAP30/IRF7/NFKBIB/DDB2/HES1/BCL2L11/JUN/STAT1/CCND3/GADD45G/RUNX3/HLA-A/STAT3/FAS/HLA-DPB1/GADD45B/PIK3R1/BID/MYC/OAS2/HLA-DRA/HLA-B/NFKBIE/CASP3/USP7/HLA-DQA2/CD58/HLA-F/HLA-DRB5/MAPK13/PSMD6/ICAM1/PSMC5/CDKN1B/CDKN1A/HLA-DMA/PSMD12/HLA-DMB/PSMC6/BLNK/CHUK/SYK/IL6/B2M/PSMC1/HLA-DPA1/CD3D	3.89957106001576
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	12/1572	27/9376	2.65083404014702	HACD4/HSD17B12/ELOVL6/SCP2/ACOX1/HACD1/SCD5/HACD3/ELOVL7/ELOVL5/HACD2/ACAA1	3.85528063016511
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	42/1572	157/9376	1.59556571206301	CCND1/CCND2/CDK6/CALM2/ZFP36L2/CXCL8/CDKN2A/RRAS/ETS1/MAP2K3/VDAC2/RASSF5/NFATC2/PPP3R1/CCND3/CALM1/GADD45G/VDAC1/NBN/HLA-A/PPP1CB/PTEN/KRAS/NFATC3/VDAC3/GADD45B/PIK3R1/PPP3CC/MYC/MAPKAPK2/HLA-B/ITPR1/HLA-F/MAPK13/HIPK2/RBBP4/CDKN1A/CHEK1/TGFBR1/CAPN2/IL6/MYBL2	3.37746520822491
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	16/1572	45/9376	2.12066723211761	GZMB/KLRC1/HLA-A/PRF1/FAS/HLA-DPB1/HLA-DRA/HLA-B/KLRD1/HLA-DQA2/HLA-F/HLA-DRB5/HLA-DMA/HLA-DMB/IL6/HLA-DPA1	3.38198840557322
NA	NA	hsa04382	Cornified envelope formation	53/1572	217/9376	1.45673713957388	KRT6A/S100A16/S100A8/SPRR3/KRT5/S100A6/S100A14/S100A4/DSG1/EVPL/PPL/S100A10/KRT24/COL7A1/S100A9/LAMB3/KRT17/KRT16/PKP1/COL4A5/S100A3/COL4A6/KRT14/TMEM79/ITGB4/LAMC2/S100A12/ABCA12/DST/DSG3/PPP2CA/CLDN3/KRT6C/SPRR1B/S100A11/CASP14/ITGA6/KRT13/S100A2/PPP2R2B/PPP2R5C/KRT10/CLDN9/PLEC/CLDN1/KRT86/KRT78/ABHD5/KRT27/KDSR/OCLN/S100A5/PKP3	3.05510009562344
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/1572	89/9376	1.74240214998428	THBS1/LAMB3/COL1A2/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/CD44/COL9A3/COL1A1/THBS3/ITGA1/ITGA6/CD36/ITGB8/COL6A2/CD47/COL6A3/LAMA2/SDC1/VWF/VTN	3.15827381888444
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	41/1572	160/9376	1.52837150127226	SLITRK6/ALCAM/CD40/NECTIN3/CADM1/VTCN1/CD99/VCAN/PTPRM/CXADR/NCAM2/CLDN3/CDH2/SDC3/ITGA6/HLA-A/SELL/HLA-DPB1/CLDN9/NLGN1/ITGB8/NRXN3/PTPRC/HLA-DRA/PTPRD/HLA-B/CLDN1/NLGN4X/HLA-DQA2/CD58/HLA-F/HLA-DRB5/NCAM1/ICAM1/NEO1/HLA-DMA/SDC2/OCLN/HLA-DMB/SDC1/HLA-DPA1	3.0253903830341
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	54/1572	224/9376	1.43784078516903	CCND1/CCND2/CD40/CDKN2A/KAT2B/ETS1/PRKACB/VDAC2/PRKACA/FDPS/JUN/NFATC2/PPP3R1/CCND3/VDAC1/HLA-A/PTEN/KRAS/NFATC3/VDAC3/HLA-DPB1/PIK3R1/PPP3CC/FOSL1/ANAPC16/MYC/HLA-DRA/BCL2L1/HLA-B/CDKN2C/EGR2/HLA-DQA2/HLA-F/CDC26/HLA-DRB5/ADCY3/ICAM1/CDKN1A/PTTG1/CHEK1/HLA-DMA/IL2RG/ATF2/TGFBR1/RAN/ANAPC15/HLA-DMB/ANAPC11/CHUK/IL6/B2M/ANAPC10/HLA-DPA1/CD3D	2.97670293777984
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/1572	20/9376	2.68396946564885	EBP/MSMO1/SC5D/CYP2R1/DHCR7/TM7SF2/CYP51A1/HSD17B7/NSDHL	3.38343145401409
Human Diseases	Immune disease	hsa05330	Allograft rejection	14/1572	39/9376	2.14105826319567	CD40/GZMB/HLA-A/PRF1/FAS/HLA-DPB1/HLA-DRA/HLA-B/HLA-DQA2/HLA-F/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-DPA1	3.20471728769869
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	30/1572	109/9376	1.64157153862315	HSP90AB1/HIF1A/HSP90AA1/RORA/NFKBIB/JUN/STAT1/NFATC2/PPP3R1/IL4R/RARA/STAT3/NFATC3/HLA-DPB1/PPP3CC/HLA-DRA/NFKBIE/HLA-DQA2/HLA-DRB5/MAPK13/AHR/IFNGR1/HLA-DMA/IL2RG/TGFBR1/HLA-DMB/CHUK/IL6/HLA-DPA1/CD3D	3.02372322483171
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	25/1572	87/9376	1.71390131906057	COX7A1/MT-CO3/COX7C/MT-CO1/UQCRB/COX6C/COX6B1/UQCRQ/COX4I1/COX7A2/COX7B/COX6A1/TPM2/CACNG4/UQCRH/COX7A2L/MYL4/TNNC1/COX5B/UQCR10/ATP1B1/CACNA2D3/UQCRHL/COX5A/COX8A	3.00238656442324
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/1572	44/9376	2.03331020124913	HSPD1/GZMB/ICA1/HLA-A/PRF1/FAS/HLA-DPB1/HLA-DRA/HLA-B/HLA-DQA2/HLA-F/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-DPA1	3.08335101709964
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/1572	57/9376	1.88348734431499	ACSL3/ACSL1/ACAT2/HACD4/ECHS1/HSD17B12/ELOVL6/SCP2/ACOX1/HACD1/MCAT/ACSF3/SCD5/HACD3/ELOVL7/ELOVL5/HACD2/ACAA1	3.0026615547054
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	49/1572	204/9376	1.43261986728534	LUM/DCN/THBS1/WNT5A/CCND1/WNT2/CAMK2D/COL1A2/ACTB/CAV1/ITGA2/ITGB5/ANK3/HIF1A/FZD6/RRAS/ACTG1/WNT10A/CD44/COL1A1/PRKACB/CAV2/MET/WNT6/PRKACA/ANK2/MSN/EZR/TWIST1/HPSE/FZD1/WNT11/STAT3/PPP1CB/KRAS/FAS/PIK3R1/HBEGF/MYC/HSPB2/CASP3/ITPR1/MAPK13/VEGFA/CDKN1A/RHOA/SDC2/SDC1/VTN	2.80377267656063
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	22/1572	75/9376	1.74955046649703	GAPDH/PRPS2/PFKP/ALDOC/ENO1/SDSL/TALDO1/PGK1/TPI1/TKT/BCAT2/BCAT1/ENO2/PFKM/PGAM4/CTH/PGAM1/IDH3A/GOT1/PKM/NAGS/IDH3B	2.92496024030923
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/1572	112/9376	1.54434750999637	LAMB3/CD40/LAMC2/HSPA1A/MAP2K3/NFKBIB/PPIF/STAT1/ALOX5/ITGA6/STAT3/HLA-DPB1/SOCS1/HSPA8/HLA-DRA/BCL2L1/CASP3/HLA-DQA2/HLA-DRB5/MAPK13/IFNGR1/GNAI3/HLA-DMA/BIRC3/HLA-DMB/LAMA2/CHUK/LDLR/HLA-DPA1	2.60099344388099
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/1572	31/9376	2.11639169334318	SRP14/SEC11C/SEC61B/SPCS1/SRP9/IMMP2L/GET3/IMMP1L/SEC61G/SPCS3/OXA1L	2.79422303878872
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	34/1572	137/9376	1.48021024869523	ACTB/TUBA4A/TUBA1A/NGF/GZMB/CTSH/CTSW/ACTG1/CTSS/BCL2L11/LMNA/JUN/GADD45G/PARP1/EIF2AK3/KRAS/PRF1/FAS/GADD45B/PIK3R1/BID/ERN1/PMAIP1/BCL2L1/CASP3/ITPR1/PARP3/BCL2A1/CTSC/CASP6/BIRC3/CAPN2/NOL3/CHUK	2.54116288310684
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	35/1572	142/9376	1.47009282156041	HSP90AB1/EDN1/MGST1/ACTB/CAV1/TXN/CALM2/THBD/CYBA/HSP90AA1/ACTG1/NCF1/BMPR1A/CAV2/NQO1/PDGFA/GSTP1/JUN/ACVR2A/CALM1/GSTO2/RAC2/PIK3R1/SUMO3/SUMO1/SUMO2/MAPK13/VEGFA/NFE2L2/ICAM1/RHOA/SDC2/CHUK/SDC1/PRKAA2	2.53329715401952
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/1572	28/9376	2.13013449654671	HACD4/ECHS1/HSD17B12/ELOVL6/HACD1/HACD3/ELOVL7/ELOVL5/HACD2/THEM4	2.68783790443986
NA	NA	hsa04518	Integrin signaling	37/1572	154/9376	1.43299957040415	THBS1/CCND1/CCND2/LAMB3/COL1A2/ACTB/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/TNC/ACTG1/COL9A3/COL1A1/THBS3/MET/FERMT1/ITGAD/PDGFA/ITGA1/CCND3/ITGA6/ITGAX/RAC2/PIK3R1/ITGB8/PDGFD/COL6A2/VEGFA/ICAM1/COL6A3/LAMA2/VWF/VTN	2.43157990498825
NA	NA	hsa04517	IgSF CAM signaling	65/1572	299/9376	1.29660360659365	SLITRK6/SLIT2/MYH14/MYLK/MBP/ACTB/FYN/TUBA4A/NECTIN3/TUBA1A/CADM1/DYNLL1/KIRREL3/ANK3/LMO7/PALS2/MAGI2/MYL9/NTRK3/MYL12B/ACTG1/MYL6/MAP2/IL1RAPL2/EPB41L2/CXADR/NCAM2/SPTBN2/CD2AP/RAP1A/ANK2/MSN/EZR/CADM2/PLXNA2/CDH2/RAPGEF6/ARPC3/ITGAX/KCNQ3/CD96/CD48/MYL6B/EPB41L1/PIK3R1/NLGN1/ROBO2/PTPRD/ABL1/SPTBN1/NLGN4X/MAPK13/NRP2/NCAM1/ICAM1/LRFN4/CADM4/IL1RAPL1/CASK/RHOA/RAP1B/PPFIA3/CSK/MYL12A/CLMP	2.33934423329301
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	40/1572	170/9376	1.40338272713666	CCND1/MYH14/ACTB/TUBA4A/TUBA1A/YBX3/PATJ/NEDD4L/MYL9/MYL12B/ACTG1/MYL6/DLG3/CRB3/PRKACB/PPP2CA/PRKACA/CLDN3/RAP1A/MSN/EZR/RAPGEF6/JUN/ARPC3/RAB13/MYL6B/PPP2R2B/CGN/CLDN9/ARHGAP17/RAP2C/CLDN1/WHAMM/MARVELD3/RHOA/OCLN/DLG2/EPB41L4B/MYL12A/PRKAA2	2.38209760174224
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	49/1572	216/9376	1.35302987465837	HSP90AB1/CAMK2D/CD40/HSPD1/SOD2/CALM2/CXCL8/CYBA/HSP90AA1/NCF1/HSPA1A/MAP2K3/IRF7/CCL3L1/RAP1A/MMP1/CXCL2/JUN/NFATC2/TANK/PPP3R1/CALM1/STAT3/EIF2AK3/CD36/KRAS/NFATC3/FAS/MIB2/PIK3R1/PPP3CC/BID/ERN1/HSPA8/BCL2L1/CASP3/ITPR1/MAPK13/OLR1/NFE2L2/ICAM1/CASP6/RHOA/RAP1B/CHUK/ATF6/LDLR/PLCB2/IL6	2.35582960938412
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	71/1572	333/9376	1.2716838976381	THBS1/WNT5A/CCND1/CCND2/WNT2/LAMB3/CDK6/COL1A2/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/PATJ/TNC/IRF9/FZD6/WNT10A/ATP6V0C/DLG3/CRB3/COL9A3/COL1A1/PRKACB/THBS3/ATP6V1B2/WNT6/PPP2CA/PRKACA/ITGA1/HES1/HES4/STAT1/CCND3/MX2/ITGA6/HLA-A/FZD1/WNT11/NOTCH2/PPP2R2B/PPP2R5C/RFNG/PSEN1/PTEN/ATP6V1F/KRAS/FAS/PIK3R1/ITGB8/PTGS2/IRF1/COL6A2/HLA-B/CASP3/HLA-F/VEGFA/CDKN1B/CDKN1A/COL6A3/PKM/LAMA2/DLG2/CHUK/ATP6AP1/PSMC1/JAG1/VWF/VTN	2.2655989206979
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	24/1572	93/9376	1.53919395879504	NFKBIB/JUN/STAT1/NFATC2/PPP3R1/IL4R/RUNX3/NOTCH2/NFATC3/HLA-DPB1/PPP3CC/HLA-DRA/NFKBIE/HLA-DQA2/HLA-DRB5/MAPK13/IFNGR1/HLA-DMA/IL2RG/HLA-DMB/CHUK/JAG1/HLA-DPA1/CD3D	2.34528483527289
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/1572	194/9376	1.35274520605441	MYH14/KLC3/ACTB/TUBA4A/TUBA1A/DYNLL1/TNNT1/MYL9/MYL12B/ACTG1/MYL6/DYNC2LI1/DNAH5/KIFC3/TNNC2/MYO16/KIF13A/KIF9/TPM2/MYL5/KIF1C/DCTN3/DYNC2H1/MYL11/KIFAP3/KIF5B/MYL6B/ACTA2/MYO15B/ACTR10/MYO5A/MYH15/DNAH7/MYO5B/MYL4/TNNC1/CAPZA2/DNAI4/DCTN2/KIF22/TUBD1/DYNLT3/DYNLT1/MYL12A	2.22816126302983
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/1572	149/9376	1.40102805813139	GABRP/MT-ND3/NDUFA4L2/NDUFB1/NDUFA4/NDUFA3/NDUFC1/NDUFB2/NDUFS5/PRKACB/NDUFB6/PRKACA/NDUFB5/NDUFS8/NDUFB7/NDUFS4/NDUFS6/NDUFA2/NDUFA1/PTGS2/NDUFB3/NDUFAB1/NDUFA12/ITPR1/MAPK13/NDUFV2/ADCY3/NDUFS7/GNAI3/NDUFB4/NDUFB8/PLCB2/NDUFB11/NDUFB10/NDUFB9	2.2145776464344
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	36/1572	155/9376	1.38527456291554	THBS1/ACTB/ITGA2/TUBA4A/ITGB5/TUBA1A/CYBA/ACTG1/NCF1/ATP6V0C/FCGR3B/THBS3/ATP6V1B2/CTSS/DYNC2H1/CLEC7A/SEC61B/HLA-A/CORO1A/CD36/ATP6V1F/HLA-DPB1/HLA-DRA/SEC22B/PLA2R1/HLA-B/EEA1/HLA-DQA2/HLA-F/HLA-DRB5/OLR1/SEC61G/HLA-DMA/HLA-DMB/ATP6AP1/HLA-DPA1	2.17070323351519
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	26/1572	105/9376	1.47689325093905	CALM2/IRF9/RRAS/BCL3/CYLD/CLEC7A/JUN/STAT1/NFATC2/PPP3R1/CALM1/KRAS/NFATC3/PIK3R1/PPP3CC/PTGS2/MAPKAPK2/IRF1/EGR2/ITPR1/MAPK13/PRKCD/RHOA/CHUK/SYK/IL6	2.20549366147952
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	25/1572	101/9376	1.47633083919079	CCND1/COL3A1/EDN1/COL1A2/F3/COL4A5/COL4A6/PLCD1/THBD/CXCL8/COL1A1/JUN/STAT1/STAT3/KRAS/PIK3R1/CASP3/MAPK13/VEGFA/ICAM1/PRKCD/CDKN1B/TGFBR1/PLCB2/IL6	2.16005946165813
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1572	31/9376	1.9239924484938	PRPS2/PFKP/ALDOC/TALDO1/TKT/GPI/PFKM/RBKS/IDNK/PGLS	2.31266588836443
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	20/1572	78/9376	1.52932733085405	TOB1/HSPD1/PFKP/BTG1/LSM5/EXOSC7/ENO1/NUDT16/C1D/ENO2/DCPS/PFKM/PABPC1/DHX36/PATL1/LSM4/TENT4B/EXOSC8/BTG3/DDX6	2.10683307497807
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	23/1572	93/9376	1.47506087717858	SNAI2/ACTB/FYN/NECTIN3/LMO7/MYL9/MYL12B/ACTG1/PTPRM/PTPRJ/RASIP1/MET/RAP1A/MYL5/SMURF2/MYL11/ARHGAP29/RAC2/WASF3/RHOA/TGFBR1/RAP1B/MYL12A	2.06633077560477
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	23/1572	93/9376	1.47506087717858	CCND1/LAMB3/CDK6/COL4A5/ITGA2/COL4A6/LAMC2/DDB2/GADD45G/FHIT/ITGA6/PTEN/GADD45B/PIK3R1/MYC/PTGS2/BCL2L1/CASP3/CDKN1B/CDKN1A/BIRC3/LAMA2/CHUK	2.06633077560477
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/1572	50/9376	1.67002544529262	THBS1/CD40/CD81/GYPC/CXCL8/HBB/THBS3/MET/CD36/KLRB1/ICAM1/SDC2/SDC1/IL6	2.13197383945266
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	10/1572	32/9376	1.86386768447837	BCKDHB/ECHS1/ACOX1/SUCLG2/SUCLA2/ABAT/SUCLG1/ECHDC1/DLD/ACSS1	2.19689389105512
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	53/1572	248/9376	1.27464499712714	HSP90AB1/S100A10/KLC3/ACTB/TUBA4A/GAPDH/TXN/TUBA1A/DYNLL1/AHNAK2/CXCL8/MYL9/PFN2/RRAS/HSP90AA1/MYL12B/ACTG1/MAP2K3/DYNC2LI1/ANXA2/PIK3C2G/CASP4/MYL5/DCTN3/DYNC2H1/JUN/ARPC3/AHNAK/BRK1/NAIP/VPS11/MYL11/KIF5B/PFN4/RAB9A/WASF3/ACTR10/CYTH4/NCKAP1L/MYC/PTPRC/RIPK2/CASP3/DCTN2/MAPK13/DYNLT3/RHOA/DYNLT1/BIRC3/MLKL/CHUK/IL6/MYL12A	1.96726559074096
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1572	154/9376	1.35554013416609	CCND1/MYLK/CAMK2D/ACTB/CAMK1D/PLA2G4A/CALM2/GUCY1A1/MYL9/ACTG1/MYL6/PRKACB/CAMK4/PRKACA/CACNG4/JUN/NFATC2/PPP3R1/CALM1/MYL6B/PPP1CB/KRAS/NFATC3/OXTR/PPP3CC/PTGS2/ITPR1/GUCY1B1/ADCY3/CACNA2D3/GNAI3/CDKN1A/RHOA/PLCB2/PRKAA2	1.99659377224823
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	43/1572	196/9376	1.30851119073584	CCND1/CDK6/RPS27A/CALM2/CXCL8/HIF1A/IRF9/UBA52/UBB/CLEC2B/IRF7/MAP1LC3A/CXCL2/JUN/STAT1/NFATC2/PPP3R1/CALM1/HLA-A/STAT3/KRAS/NFATC3/FAS/PIK3R1/PPP3CC/BID/MYC/PTGS2/MAPKAPK2/HLA-B/CASP3/ITPR1/HLA-F/MAPK13/VEGFA/PREX1/IFNGR1/ICAM1/CDKN1A/CHUK/SYK/IL6/CCR3	1.95898403081391
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/1572	46/9376	1.68558468857174	PSMB8/PSMB10/PSME4/PSMA7/PSMB9/PSMD6/PSMB1/PSMC5/PSMB6/PSMD12/PSMC6/PSMD9/PSMC1	2.09195569468578
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/1572	99/9376	1.44590947644383	DSG1/KRT24/KRT17/KRT16/KRT14/FCGR3B/CFD/KRT13/HLA-DPB1/KRT10/HLA-DRA/C5/HLA-DQA2/HLA-DRB5/FPR1/PTAFR/KRT27/ICAM1/CFB/HLA-DMA/HLA-DMB/CFH/C5AR1/HLA-DPA1	2.00176826432038
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1572	104/9376	1.43374437267567	PLAAT2/AGPAT2/DGKB/PLA2G4A/ETNK2/MBOAT2/CHPT1/MBOAT7/ACHE/CHAT/LPGAT1/DGKD/MBOAT1/AGPAT3/TAFAZZIN/SGMS1/SAMD8/GPCPD1/LPCAT2/CDS1/PEMT/GPAT3/AGPAT5/SGMS2/PLB1	1.9962599335495
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/1572	12/9376	2.48515691263783	NQO1/GGCX/COQ4/COQ3/COQ5	2.31039129827159
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	17/1572	66/9376	1.53627881872157	RORA/JUN/STAT1/IL4R/STAT3/HLA-DPB1/HLA-DRA/HLA-DQA2/HLA-DRB5/NOD2/IFNGR1/HLA-DMA/IL18R1/IL2RG/HLA-DMB/IL6/HLA-DPA1	1.96218996375468
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1572	126/9376	1.37275334221899	COL3A1/MYLK/COL1A2/ACTB/FYN/ITGA2/PLA2G4A/GUCY1A1/MYL12B/ACTG1/COL1A1/PRKACB/PRKACA/RAP1A/PPP1CB/PIK3R1/F2R/ITPR1/STIM1/GUCY1B1/MAPK13/ADCY3/GNAI3/RHOA/RAP1B/PLCB2/SYK/MYL12A/VWF	1.89055462852757
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	10/1572	34/9376	1.75422840892082	NR1D1/RORA/PER3/NPAS2/RORB/NR1D2/DBP/FBXL3/CRY2/PRKAA2	1.9773142323203
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	13/1572	48/9376	1.61535199321459	BCKDHB/OXCT1/ACAT2/ECHS1/IVD/BCAT2/ACSF3/MCCC1/BCAT1/ABAT/DLD/HMGCL/ACAA1	1.91824131401567
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/1572	17/9376	2.10507409070498	TXNRD2/KYAT3/TXNRD1/PSTK/CTH/MARS1	2.04670105020764
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/1572	30/9376	1.78931297709924	SUCLG2/SUCLA2/SUCLG1/IDH3A/DLD/FH/MDH1/MDH2/IDH3B	1.94334658190222
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	52/1572	250/9376	1.2405903307888	OSBPL1A/OSBPL3/AP2S1/CTSH/CTSW/IDS/ATP6V0C/OSBPL5/BLOC1S2/ATP6V1B2/LITAF/CTSS/BORCS5/AP1G1/OSBPL6/SORT1/SUMF1/VPS29/VPS11/NCOA7/AP1S3/AP5Z1/AP1M2/ATP6V1F/HYAL3/HYAL1/DMXL2/MANBA/SNAPIN/LAMTOR4/LAPTM4B/LAMTOR5/BORCS7/AP3M2/LAMTOR2/ASAH1/AP1M1/BLOC1S5/AP2A1/CTSC/MCOLN1/HYAL2/AP1S1/AKT1S1/NPC1/FUCA1/AP3S2/SLC11A1/ATP6AP1/VPS26B/SMPD1/GPR155	1.73045862593073
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/1572	93/9376	1.41092779556212	KCNN4/ATP2B4/LYZ/CST3/KCNMA1/ATP2B1/CALM2/GUCY1A1/ADRA1B/BST1/PRKACB/PRKACA/ADRB2/CALM1/VAMP2/SLC12A2/CST2/ITPR1/GUCY1B1/ATP1B1/ADCY3/PLCB2	1.78737671593665
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/1572	54/9376	1.54631985675243	CD40/GZMB/HLA-A/PRF1/FAS/HLA-DPB1/HLA-DRA/HLA-B/HLA-DQA2/HLA-F/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-DPA1	1.806935270289
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/1572	105/9376	1.36328607778989	RPS27A/HIF1A/TOMM7/UBA52/RRAS/OPTN/UBB/MAP1LC3A/JUN/GABARAPL2/MARCHF5/SMURF2/BNIP3/USP15/EIF2AK3/RABGEF1/KRAS/FUNDC1/BCL2L1/PRKN/SAMM50/VCP/TOMM20/ATG9B	1.6800932709609
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1572	184/9376	1.26418851642881	WNT5A/SLIT2/CAMK2D/FYN/ABLIM3/NGEF/EPHB4/DPYSL2/MYL9/RRAS/MYL12B/MET/RGS3/EFNA5/SEMA3C/MYL5/EPHA2/PLXNA2/RHOD/NFATC2/PPP3R1/EPHA4/CFL1/RAC2/EPHA1/KRAS/NFATC3/PIK3R1/PPP3CC/ABLIM1/ROBO2/ABL1/PLXNB1/GNAI3/TRPC1/NEO1/SEMA4F/RHOA/MYL12A	1.62431822970801
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	20/1572	85/9376	1.40338272713666	ENPP1/ADSS2/GUK1/DCTPP1/NUDT16/NME3/DCK/NME7/TYMS/IMPDH1/NME1/HPRT1/RRM2B/AK4/NT5M/AK3/UPP1/TK1/GMPS/RRM1	1.67667469279023
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1572	116/9376	1.33684302886725	ACTB/CYBA/CD99/MYL9/MYL12B/ACTG1/NCF1/CLDN3/RAP1A/MSN/MYL5/EZR/RASSF5/MYL11/RAC2/THY1/PIK3R1/CLDN9/CLDN1/MAPK13/ICAM1/GNAI3/RHOA/RAP1B/OCLN/MYL12A	1.63834116620651
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1572	41/9376	1.60019859740582	THBS1/CCND1/CXCL8/CDKN2A/MMP1/KRAS/HBEGF/MYC/VEGFA/CDKN1A/RASSF1	1.72855428123246
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1572	139/9376	1.28727552309298	HSP90AB1/KRT24/KRT17/KRT16/FKBP5/KRT14/CALM2/HSP90AA1/HSPA1A/PRKACB/PRKACA/JUN/CALM1/EBAG9/RARA/KRT13/KRAS/PIK3R1/HBEGF/KRT10/HSPA8/ITPR1/KRT27/ADCY3/PRKCD/GNAI3/GABBR1/ATF2/PLCB2/FKBP4	1.53141829521415
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	39/1572	187/9376	1.24390741723476	HSP90AB1/TXNIP/TXN/GBP2/CXCL8/CYBA/NAMPT/IRF9/HSP90AA1/IRF7/VDAC2/MAP1LC3A/NFKBIB/CASP4/CXCL2/JUN/STAT1/NEK7/TANK/NAIP/GABARAPL2/VDAC1/ANTXR1/DNM1L/TRIP6/VDAC3/CARD16/OAS2/RIPK2/BCL2L1/ITPR1/MAPK13/NOD2/PRKCD/RHOA/BIRC3/CHUK/PLCB2/IL6	1.51204586072276
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/1572	82/9376	1.38198969775957	HSP90AB1/HSP90AA1/HSPA1A/CTSS/KLRC1/HLA-A/HLA-DPB1/HSPA8/HLA-DRA/HLA-B/KLRD1/HLA-DQA2/HLA-F/HLA-DRB5/KLRC3/HLA-DMA/HLA-DMB/B2M/HLA-DPA1	1.55923121656581
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	16/1572	67/9376	1.42432873798944	CAMK2D/CALM2/PRKACB/CAMK4/PRKACA/RAP1A/RPS6KA2/PPP3R1/CALM1/GRIN2B/PPP1CB/KRAS/PPP3CC/ITPR1/RAP1B/PLCB2	1.56437767862345
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	42/1572	205/9376	1.22196983801899	CCND1/CCND2/CDK6/IRF9/CDKN2A/KAT2B/GSN/H2BC12/YWHAZ/PRKACB/IRF7/PRKACA/JUN/CCND3/H4C3/HLA-A/STAT3/KRAS/VDAC3/PIK3R1/MAPKAPK2/PMAIP1/HLA-B/SCIN/EGR2/CASP3/USP7/HLA-F/YWHAH/H2BC11/CDKN1B/CDKN1A/CHEK1/RHOA/ATF2/PKM/YWHAB/GTF2B/SYK/PSMC1/H2BC5/CCR3	1.44216790954941
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	19/1572	83/9376	1.36533921947331	L3MBTL4/PHF19/PCGF5/CBX6/UBE2D1/CBX4/KDM2A/SCMH1/MBD6/USP7/RBBP4/EPOP/OGT/YAF2/SCML1/TFDP1/UBE2D2/FBRS/EZH2	1.50041242840686
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1572	83/9376	1.36533921947331	CROT/SOD2/ACSL3/ACSL1/PEX2/PMVK/ECI2/SCP2/MVK/ACOX1/NUDT12/DECR2/PEX16/NUDT7/HMGCL/ABCD3/NUDT19/PEX11A/ACAA1	1.50041242840686
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	17/1572	73/9376	1.3889644114469	MAP1B/MDFIC/APOBEC3C/CHMP4A/KAT2B/BST2/PPIA/PIN1/MX2/SAMHD1/APOBEC3A/PSIP1/APOBEC3F/CCNT1/CHMP4B/RAN/RANBP2	1.4973146208148
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1572	157/9376	1.2536587737638	WNT5A/CCND1/CCND2/WNT2/SNAI2/ACTB/AREG/PATJ/FZD6/ACTG1/WNT10A/DLG3/BMPR1A/YWHAZ/WNT6/PPP2CA/CCND3/FZD1/WNT11/PPP2R2B/BMP2/PPP1CB/MYC/SMAD7/YAP1/YWHAH/CCN2/RASSF1/TGFBR1/BIRC3/YWHAB/DLG2/TP53BP2	1.43850404043672
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	26/1572	120/9376	1.29228159457167	CAMK2D/CALM2/NGF/NTRK3/CAMK4/NFKBIB/RAP1A/RPS6KA2/NTF4/JUN/SORT1/CALM1/PSEN1/KRAS/PIK3R1/RIPK2/MAPKAPK2/ABL1/NFKBIE/CRK/MAPK13/PRKCD/RHOA/RAP1B/ARHGDIA/PRDM4	1.44621778084095
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1572	115/9376	1.29660360659365	PDE4D/NACA/JUND/MAFB/PRKACB/PTHLH/PRKACA/AKAP13/OXSR1/STK39/PDE4B/WNK3/MMP16/HBEGF/MMP24/LRP5/ITPR1/ADCY3/RUNX2/GNAI3/CDKN1A/RHOA/ATF2/PLCB2/SLC12A3	1.43631496147035
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/1572	142/9376	1.26007956133749	FYN/CYBA/JUND/IRF9/NCF1/FCGR3B/CAMK4/CYLD/JUN/STAT1/NFATC2/PPP3R1/JUNB/FOSL2/PIK3R1/LILRB4/SOCS1/PPP3CC/FOSL1/SIRPA/ITPR1/TYROBP/MAPK13/IFNGR1/LILRA5/TEC1/TGFBR1/BLNK/CHUK/SYK	1.40155046479528
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	22/1572	100/9376	1.31216284987277	ITGA2/CD59/CD9/CD44/CD55/CD7/ITGA1/IL4R/ITGA6/CD36/HLA-DPB1/HLA-DRA/HLA-DQA2/HLA-DRB5/CD37/HLA-DMA/KITLG/HLA-DMB/ANPEP/IL6/HLA-DPA1/CD3D	1.40849116012852
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/1572	69/9376	1.38304384703323	EDN1/KCNMA1/CALM2/GUCY1A1/EDN2/PRKACB/PDE3A/PRKACA/ADRB2/PPP3R1/CALM1/PPP3CC/ITPR1/GUCY1B1/GNAI3/PLCB2	1.43324837355325
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	14/1572	59/9376	1.41527580109544	ENPP1/DPYD/DCTPP1/NME3/DCK/NME7/TYMS/NUDT2/NME1/RRM2B/NT5M/UPP1/TK1/RRM1	1.43607744572526
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1572	90/9376	1.32541702007351	HIF1A/MAP2K3/EML4/NFKBIB/JUN/STAT1/NFATC2/PPP3R1/STAT3/PTEN/KRAS/NFATC3/PIK3R1/PPP3CC/BATF/NFKBIE/MAPK13/IFNGR1/CHUK/CD3D	1.39219624340613
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	32/1572	155/9376	1.23135516703603	WNT5A/CCND1/WNT2/CAMK2D/CDK6/PBX1/FZD6/CDKN2A/WNT10A/PRKACB/WNT6/PRKACA/RAP1A/HSD3B1/NR4A1/FZD1/WNT11/KMT2A/CDKN2C/ITPR1/AHR/ADCY3/FH/GNAI3/CDKN1B/CDKN1A/NCEH1/ATF2/RAP1B/LDLR/PLCB2/RBBP5	1.30349485150324
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	46/1572	232/9376	1.18259191015179	TMSB4X/MYH14/MYLK/RGCC/ACTB/ITGA2/ITGB5/ITGB6/ITGB4/MYL9/CYRIB/PFN2/RRAS/GSN/MYL12B/ACTG1/ITGAD/PDGFA/ITGA1/MSN/MYL5/EZR/ARPC3/BRK1/ITGA6/MYL11/ITGAX/CFL1/PFN4/RAC2/PPP1CB/SPATA13/KRAS/PIK3R1/ITGB8/NCKAP1L/DIAPH3/F2R/PDGFD/SCIN/C5/CRK/RHOA/PIP5K1B/C7/MYL12A	1.2638941228852
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1572	21/9376	1.70410759723737	ENPP1/DPYD/BCAT2/BCAT1/PPCS/VNN2	1.44970641429549
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	36/1572	178/9376	1.20627841152758	WNT5A/CCND1/CCND2/WNT2/CAMK2D/DKK1/ROR2/LGR5/PRICKLE1/FZD6/CTNNBIP1/WNT10A/DKK2/PRKACB/WNT6/PRKACA/CACYBP/JUN/NFATC2/PPP3R1/CCND3/SFRP2/FZD1/WNT11/RAC2/PSEN1/CTBP1/NFATC3/CBY1/PPP3CC/MCC/FOSL1/MYC/LRP5/RHOA/PLCB2	1.24701120440414
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	69/1572	362/9376	1.13685631141664	THBS1/HSP90AB1/CCND1/EREG/CCND2/LAMB3/CDK6/COL1A2/AREG/COL4A5/ITGA2/ITGB5/COL4A6/ITGB6/ITGB4/LAMC2/NGF/TNC/MAGI2/HSP90AA1/COL9A3/COL1A1/YWHAZ/THBS3/MET/PPP2CA/PRL/PDGFA/EFNA5/ITGA1/BCL2L11/EPHA2/NTF4/CCND3/IL4R/NR4A1/GHR/ITGA6/PPP2R2B/PPP2R5C/PTEN/KRAS/PIK3R1/ITGB8/MYC/F2R/PDGFD/BCL2L1/COL6A2/PRLR/VEGFA/OSMR/YWHAH/CDKN1B/CDKN1A/IL2RG/COL6A3/ATF2/YWHAB/SGK3/KITLG/LAMA2/CHUK/SYK/IL6/PRKAA2/VWF/THEM4/VTN	1.1918280918561
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	34/1572	168/9376	1.2070762147098	HSP90AB1/FTH1/CAMK2D/FTL/H2AJ/HMGB1/PLA2G4A/MACROH2A1/IRF9/CHMP4A/HSP90AA1/VDAC2/CYLD/H2AZ1/PPIA/H2AZ2/STAT1/VDAC1/H2AC20/PARP1/STAT3/MACROH2A2/DNM1L/FAS/VDAC3/BID/H2AC8/IFNGR1/GLUD1/CHMP4B/BIRC3/CAPN2/MLKL/SMPD1	1.21550145166281
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1572	51/9376	1.40338272713666	ACTB/ACTG1/ATP6V0C/PRKACB/ATP6V1B2/PRKACA/SEC61B/ATP6V1F/SLC12A2/ADCY3/SEC61G/ATP6AP1	1.29637678204807
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	17/1572	77/9376	1.31681041604706	CCND1/CDK6/CDKN2A/DDB2/STAT1/GADD45G/STAT3/RAC2/KRAS/GADD45B/PIK3R1/BCL2L1/RALGDS/VEGFA/CDKN1A/TGFBR1/CHUK	1.25279487835081
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1572	77/9376	1.31681041604706	CCND1/CDK6/CDKN2A/DDB2/GADD45G/CTBP1/KRAS/GADD45B/PIK3R1/MYC/BCL2L1/ABL1/CRK/CDKN1B/CDKN1A/TGFBR1/CHUK	1.25279487835081
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	29/1572	142/9376	1.21807690929291	FBXO2/RPS27A/NEDD4L/UBA52/ELOB/UBE2E3/UBB/RNF7/DDB2/UBE2B/FANCL/UBE2D1/SMURF2/PIAS2/SOCS1/UBE2M/ANAPC16/NHLRC1/PRKN/CDC26/UBE2S/STUB1/BIRC3/ANAPC15/ANAPC11/UBE2D2/CBLC/ANAPC10/VHL	1.17520112695043
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	17/1572	78/9376	1.29992823122594	CYBA/MARCKSL1/NCF1/FCGR3B/NFKBIB/JUN/STAT1/HLA-DPB1/PTGS2/HLA-DRA/HLA-DQA2/HLA-DRB5/MAPK13/IFNGR1/HLA-DMA/HLA-DMB/HLA-DPA1	1.19377685759574
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1572	170/9376	1.19287531806616	WNT5A/CCND1/WNT2/CDK6/MGST1/ACTB/FZD6/CDKN2A/ACTG1/WNT10A/TXNRD2/MET/NQO1/WNT6/DDB2/GSTP1/GADD45G/TXNRD1/FZD1/WNT11/GSTO2/PTEN/KRAS/GADD45B/PIK3R1/MYC/DPF3/BCL2L1/LRP5/NFE2L2/PHF10/CDKN1A/ARID1B/TGFBR1	1.13898737276625
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1572	73/9376	1.30726062253826	CCND1/CDK6/CDKN2A/MET/EML4/DDB2/RASSF5/GADD45G/FHIT/STAT3/KIF5B/KRAS/GADD45B/PIK3R1/CDKN1A/RASSF1	1.18279670064365
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1572	42/9376	1.42008966436447	FTH1/FTL/ACSL3/ACSL1/VDAC2/MAP1LC3A/CP/SAT2/PRNP/VDAC3	1.22457678542862
Human Diseases	Immune disease	hsa05310	Asthma	8/1572	32/9376	1.4910941475827	CD40/HLA-DPB1/HLA-DRA/HLA-DQA2/HLA-DRB5/HLA-DMA/HLA-DMB/HLA-DPA1	1.24889696899452
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/1572	138/9376	1.21016336615407	CAMK2D/CALM2/YWHAZ/PRKACB/PPP2CA/PRKACA/RPS6KA2/PPP3R1/CALM1/PPP2R5C/PPP1CB/PPP3CC/ANAPC16/CPEB2/SPDYE2/SLK/CPEB4/ITPR1/CDC26/MAPK13/ADCY3/YWHAH/PTTG1/YWHAB/ANAPC15/ANAPC11/ANAPC10/SPDYA	1.11624842417493
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	20/1572	95/9376	1.25565822954332	CXCL8/ATP6V0C/ATP6V1B2/CCL3L1/MMP1/CXCL2/JUN/ATP6V1F/HLA-DPB1/HLA-DRA/HLA-DQA2/HLA-DRB5/VEGFA/ICAM1/HLA-DMA/TNFSF13/HLA-DMB/ATP6AP1/IL6/HLA-DPA1	1.12402888578134
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1572	128/9376	1.21151399491094	ENPP1/PDE4D/GUCY1A1/PRPS2/ADSS2/GUK1/PDE3A/NUDT16/NME3/FHIT/DCK/NME7/PDE4B/IMPDH1/NUDT2/NME1/PAICS/HPRT1/RRM2B/AK4/NT5M/AK3/GUCY1B1/ADCY3/GMPS/RRM1	1.0813678685008
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/1572	69/9376	1.29660360659365	CAMK2D/TH/CALM2/PRKACB/CAMK4/PRKACA/JUN/PPP3R1/CALM1/GRIN2B/PPP1CB/PPP3CC/MAOB/ARC/ATF2	1.10981194459313
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1572	23/9376	1.55592432791238	ACAT2/PMVK/FDPS/MVK/MVD/HMGCR	1.19800163074901
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1572	33/9376	1.44590947644383	BCKDHB/BCAT2/BCAT1/IDH3A/DLD/GOT1/NAGS/IDH3B	1.15163213866296
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	34/1572	173/9376	1.17218961890894	CDK6/ACTB/CXCL8/IRF9/ACTG1/PRSS3/IRF7/NFKBIB/FDPS/STAT1/CCND3/MX2/HNRNPUL1/VDAC1/TPSB2/DNAJB1/FAS/HLA-DPB1/PIK3R1/BID/TPSAB1/OAS2/HLA-DRA/CASP3/HLA-DQA2/HLA-DRB5/IFNGR1/ICAM1/HLA-DMA/HLA-DMB/CHUK/DNAJC3/IL6/HLA-DPA1	1.0259320187083
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/1572	28/9376	1.4910941475827	TH/PCBD1/GCH1/QDPR/GPHN/GGH/ALPP	1.16798617204833
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1572	70/9376	1.27808069792803	HIF1A/ELOB/ETS1/MET/RAP1A/JUN/KRAS/PIK3R1/FLCN/CRK/VEGFA/FH/CDKN1A/RAP1B/VHL	1.04807320836241
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1572	49/9376	1.33894168354365	TH/PRKACB/GPSM1/PRKACA/JUN/RGS9/GRIN2B/MAOB/GNAI3/ATF2/CDK5R1	1.06759200460418
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	24/1572	119/9376	1.20289948040285	EDN1/MAP2K3/BCL3/ADAM17/CYLD/CXCL2/JUN/JUNB/DNM1L/FAS/PIK3R1/PTGS2/IRF1/CASP3/MAPK13/NOD2/ICAM1/IL18R1/ATF2/BIRC3/MLKL/CHUK/IL6/JAG1	0.999706607105623
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1572	44/9376	1.35554013416609	HMGB1/ADPRS/POLD2/APEX1/PARP1/POLE3/UNG/NEIL1/NTHL1/PARP3	1.06091571821853
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	10/1572	44/9376	1.35554013416609	DYNLL1/DYNC2LI1/PRKACB/PRKACA/DYNC2H1/VAMP2/DCTN2/ADCY3/ARHGDIA/STX4	1.06091571821853
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/1572	253/9376	1.13158132939082	ACTB/H3-3B/CAST/RPS27A/PLCD1/H3-3A/CXCL8/MYL9/UBA52/PFN2/MYL12B/ACTG1/CD44/SEPTIN7/UBB/MAP1LC3A/CAPNS1/NFKBIB/CASP4/MYL5/U2AF1/JUN/ARPC3/NAIP/UBE2D1/GLMN/BNIP3/VDAC1/MYL11/PFN4/SEPTIN6/PIK3R1/FNBP1/CYTH4/RIPK2/BCL2L1/CRK/ITPR1/MAPK13/PRKCD/TNIP1/AKT1S1/RHOA/CAPN2/UBE2D2/CHUK/PLCB2/MYL12A	0.952223667576701
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1572	76/9376	1.25565822954332	CCND1/CAMK2D/CDK6/CAMK1D/CALM2/CDKN2A/CAMK4/PDGFA/DDB2/CALM1/GADD45G/PTEN/KRAS/GADD45B/PIK3R1/CDKN1A	1.00433449115444
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1572	60/9376	1.29228159457167	PLA2G4A/MAPKAPK3/NFATC2/PPP3R1/RAC2/KRAS/PIK3R1/PPP3CC/PTGS2/MAPKAPK2/MAPK13/VEGFA/HSPB1	1.0193319382431
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1572	14/9376	1.70410759723737	CHST2/ST3GAL1/B3GNT2/ST3GAL3	1.18323772691922
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1572	87/9376	1.23400894972361	CCND1/EREG/AREG/DDB2/BCL2L11/JUN/GADD45G/RAC2/KRAS/GADD45B/PIK3R1/MYC/PMAIP1/CASP3/RALGDS/CDKN1A/RHOA/TGFBR1	0.984149080337186
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1572	98/9376	1.21721971231241	ASAP2/PLA2G4A/MARCKSL1/GSN/NCF1/FCGR3B/ARPC3/CFL1/RAC2/WASF3/PIK3R1/MARCKS/PTPRC/BIN1/SCIN/CRK/PRKCD/ASAP1/PIP5K1B/SYK	0.970148835286136
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/1572	19/9376	1.56957278692915	IDS/HPSE/HYAL3/HYAL1/HYAL2	1.1153495485119
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/1572	88/9376	1.21998612074948	F3/SERPINB2/CLU/THBD/CD59/CD55/F12/CFD/ITGAX/F2R/C5/F5/CFB/C7/CFH/C5AR1/VWF/VTN	0.930526600928204
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	20/1572	99/9376	1.20492456370319	EDN1/ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/ITGA1/TPM2/LMNA/CACNG4/SGCB/ITGA6/ITGB8/TNNC1/CACNA2D3/LAMA2/SNTA1/IL6/PRKAA2	0.919943418723061
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	22/1572	110/9376	1.19287531806616	DCN/THBS1/EMP3/NBL1/THSD4/ID4/BMPR1A/PPP2CA/ACVR2A/TMEM53/SMURF2/ZFYVE16/BMP2/SKI/MYC/SMAD7/ACVR1B/NEO1/RHOA/TGFBR1/TFDP1/TFR2	0.913229913320124
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1572	56/9376	1.27808069792803	HSPD1/CXCL8/HSPA1A/CLK1/CXCL2/NAIP/BNIP3/HSPA8/SEC22B/CASP3/VCP/IL6	0.936720836410557
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1572	67/9376	1.24628764574076	GAPDH/PFKP/ALDOC/ENO1/PGK1/TPI1/GPI/ENO2/PFKM/PGAM4/PGAM1/DLD/PKM/ACSS1	0.907991519365712
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	38/1572	201/9376	1.12759358424164	CCND2/CD40/H3-3B/SPINT1/ETV1/H3-3A/PBX1/CXCL8/HMGA2/MLF1/MEIS1/CDK14/GZMB/PBX3/DUSP6/NR4A3/MET/PDGFA/DDB2/BCL6/GADD45G/RARA/ZBTB16/GADD45B/SUPT3H/KMT2A/MYC/BCL2L1/CDKN2C/CCNT1/BCL2A1/RUNX2/CDKN1B/CDKN1A/BIRC3/BCL11B/IL6/KLF3	0.820686157684612
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1572	134/9376	1.15726709961642	AVPR1A/MYH14/EDN1/MYLK/KCNMB4/KCNMA1/PLA2G4A/CALM2/GUCY1A1/ADRA1B/MYL9/MYL6/EDN2/RAMP1/PRKACB/PRKACA/CALM1/MYL6B/ACTA2/PPP1CB/ITPR1/GUCY1B1/ADCY3/PRKCD/RHOA/PLCB2	0.8229256007831
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1572	41/9376	1.30925339787749	GRHPR/SDSL/SRR/PGAM4/CTH/PGAM1/MAOB/DLD/GAMT	0.890640676598218
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/1572	52/9376	1.26169504795459	LPL/OSBPL5/VDAC2/VAPA/SORT1/VDAC1/CD36/VDAC3/NCEH1/NPC1/LDLR	0.84927692162441
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1572	47/9376	1.26901629581506	GRHPR/ACAT2/ACYP2/ME3/DLD/FH/MDH1/MDH2/PKM/ACSS1	0.82978054766084
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/1572	91/9376	1.17976679808741	IFITM1/CD81/NFKBIB/JUN/NFATC2/PPP3R1/RAC2/KRAS/NFATC3/PIK3R1/LILRB4/DAPP1/PPP3CC/NFKBIE/LILRA5/BLNK/CHUK/SYK	0.773379229053406
Human Diseases	Infectious disease: viral	hsa05162	Measles	26/1572	136/9376	1.14024846579853	CCND1/CCND2/CDK6/IRF9/HSPA1A/IRF7/NFKBIB/MSN/JUN/STAT1/CCND3/MX2/STAT3/RAB9A/FAS/PIK3R1/BID/HSPA8/OAS2/BCL2L1/CASP3/CDKN1B/IL2RG/CHUK/IL6/CD3D	0.739409228054322
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1572	75/9376	1.19287531806616	MGST1/ABCC2/CDKN2A/XPA/GSTP1/GSTO2/FAS/PIK3R1/BID/PMAIP1/BCL2L1/CASP3/ERCC1/CDKN1A/BIRC3	0.752654640209929
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1572	37/9376	1.2895949384499	CCND1/DDB2/CCDC6/GADD45G/KRAS/GADD45B/MYC/CDKN1A	0.792127188483226
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1572	48/9376	1.24257845631891	EPCAM/CD81/CHMP4A/CD9/CLDN3/CLDN9/CLDN1/CHMP4B/OCLN/LDLR	0.756191613795289
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/1572	59/9376	1.21309354379609	MGST1/ODC1/GPX1/GGCT/GGT5/LANCL1/GSTP1/GSTO2/RRM2B/SMS/RRM1/ANPEP	0.736905043029237
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1572	98/9376	1.15635872669679	CAMK2D/ATP2B4/CAMK1D/ATP2B1/CALM2/PRKACB/CAMK4/PRKACA/HSD3B1/CALM1/NR4A1/PRKD1/ITPR1/ATP1B1/ADCY3/ATF2/PRKD2/LDLR/PLCB2	0.698330897214094
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1572	32/9376	1.30470737913486	BOK/BCL2L11/BID/PMAIP1/BCL2L1/CASP3/BIRC3	0.774898507964215
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	15/1572	76/9376	1.17717959019687	ACSL3/ACSL1/LPL/SLC27A6/FABP5/ME3/SCP2/MMP1/ACOX1/SLC27A5/CD36/DBI/SCD5/OLR1/ACAA1	0.69603694698655
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	15/1572	76/9376	1.17717959019687	MYLK/CAMK2D/ACTB/CALM2/ACTG1/PRKACB/PRKACA/EZR/CALM1/ITPR1/KCNJ16/ATP1B1/ADCY3/GNAI3/PLCB2	0.69603694698655
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/1572	54/9376	1.21496560173405	SDSL/CISD1/KYAT3/BCAT2/BCAT1/CTH/SMS/MDH1/APIP/MDH2/GOT1	0.710991780494946
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	21/1572	110/9376	1.13865371269951	HSP90AB1/HSP90AA1/CDC25B/PRKACB/PRKACA/RPS6KA2/KRAS/PIK3R1/ANAPC16/CPEB2/SPDYE2/CPEB4/KIF22/CDC26/MAPK13/ADCY3/GNAI3/ANAPC15/ANAPC11/ANAPC10/SPDYA	0.656500371844666
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	14/1572	71/9376	1.17607425724832	CCND1/CCND2/TH/PRL/STAT1/STAT3/KRAS/PIK3R1/SOCS1/IRF1/SOCS6/PRLR/MAPK13/SOCS5	0.668374895730952
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1572	71/9376	1.17607425724832	CXCL8/ATP6V0C/ATP6V1B2/ADAM17/MET/CXCL2/JUN/ATP6V1F/HBEGF/CASP3/MAPK13/CHUK/ATP6AP1/CSK	0.668374895730952
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1572	71/9376	1.17607425724832	PFKP/HIF1A/NTRK3/MET/SLC7A5/PTEN/KRAS/PIK3R1/PFKM/MYC/PGAM4/PGAM1/GLS/PKM	0.668374895730952
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	25/1572	133/9376	1.12112341923511	FYN/GZMB/FCGR3B/NFATC2/PPP3R1/KLRC1/HLA-A/CD48/RAC2/KRAS/PRF1/FAS/PIK3R1/HCST/PPP3CC/BID/HLA-B/KLRD1/CASP3/TYROBP/KLRC3/IFNGR1/ICAM1/SYK/NCR1	0.631394427813655
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/1572	38/9376	1.25565822954332	ENPP1/NAMPT/BST1/SIRT2/NUDT12/NT5M/NNT/NADK	0.708725271981124
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1572	38/9376	1.25565822954332	SFN/NR3C2/NEDD4L/FXYD4/SCNN1A/KRAS/PIK3R1/ATP1B1	0.708725271981124
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	20/1572	105/9376	1.13607173149158	ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/PRKACB/PRKACA/ITGA1/TPM2/LMNA/CACNG4/SGCB/ITGA6/ITGB8/TNNC1/ADCY3/CACNA2D3/LAMA2/SNTA1	0.62929248992365
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	54/1572	300/9376	1.07358778625954	EREG/AREG/PLA2G4A/NGF/JUND/DUSP10/RRAS/CDC25B/HSPA1A/MAPKAPK3/MAP2K3/DUSP6/PRKACB/MET/PRKACA/PDGFA/EFNA5/RAP1A/RPS6KA2/EPHA2/CACNG4/NTF4/JUN/PPP3R1/NR4A1/GADD45G/RAC2/KRAS/NFATC3/FAS/GADD45B/PPP3CC/PTPN7/MAP3K21/MYC/HSPA8/MAPKAPK2/PDGFD/MAP4K4/CRK/CASP3/MAPK13/VEGFA/CACNA2D3/HSPB1/MAP3K13/DUSP8/ATF2/TGFBR1/RAP1B/DUSP5/KITLG/CHUK/ECSIT	0.581396483528595
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	46/1572	254/9376	1.08016268958747	AVPR1A/MYLK/CAMK2D/ATP2B4/CAMK1D/ORAI3/PLCD1/ATP2B1/CALM2/ADRA1B/GNA15/NGF/NTRK3/PRKACB/CAMK4/VDAC2/TNNC2/MET/PRKACA/PDGFA/ADRB2/PPIF/NFATC2/PPP3R1/CALM1/MST1R/VDAC1/GRIN2B/PTGFR/HRH1/NFATC3/VDAC3/OXTR/SLN/PPP3CC/TNNC1/F2R/PDGFD/ITPR1/STIM1/PTAFR/VEGFA/ADCY3/MCOLN1/ITPKB/PLCB2	0.581296065030878
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	39/1572	214/9376	1.08696582720982	CALM2/APOBEC3C/ELOB/MAP2K3/BST2/RNF7/AP1G1/JUN/NFATC2/PPP3R1/CALM1/SAMHD1/HLA-A/CFL1/APOBEC3A/RAC2/AP1S3/AP1M2/KRAS/NFATC3/FAS/PIK3R1/PPP3CC/BID/APOBEC3F/BCL2L1/HLA-B/CRK/CASP3/ITPR1/HLA-F/MAPK13/AP1M1/GNAI3/AP1S1/CHEK1/CHUK/B2M/CD3D	0.577582004893385
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1572	17/9376	1.40338272713666	CYP7B1/SCP2/HSD3B7/SLC27A5	0.747102713031234
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1572	17/9376	1.40338272713666	MYH14/PCDH7/PCDH9/NRP2	0.747102713031234
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	45/1572	250/9376	1.07358778625954	EHD2/ASAP2/CAV1/ARF5/NEDD4L/AP2S1/AGAP1/CHMP4A/WASHC3/EPN3/FOLR3/HSPA1A/CAV2/ARAP2/SH3KBP1/ARPC3/VPS29/SMURF2/ZFYVE16/HLA-A/KIF5B/STAM/CYTH4/HSPA8/EHD1/BIN1/HLA-B/EEA1/CAPZA2/RAB11FIP4/HLA-F/RAB22A/AP2A1/RAB11FIP1/ASAP1/CHMP4B/RHOA/RAB4A/IL2RG/PIP5K1B/TGFBR1/LDLR/VTA1/VPS26B/CBLC	0.529284028491379
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/1572	50/9376	1.19287531806616	CD40/HLA-DPB1/HLA-DRA/HLA-DQA2/HLA-DRB5/HLA-DMA/TNFSF13/HLA-DMB/IL6/HLA-DPA1	0.613715695847303
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/1572	28/9376	1.27808069792803	B3GNT3/B3GNT2/GCNT2/ST3GAL3/FUT4/B3GNT4	0.661368927917816
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1572	12/9376	1.4910941475827	NCAM2/NCAM1/NPC1	0.763972907880784
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1572	23/9376	1.29660360659365	GLS/ATP1B1/MDH1/GLUD1/SLC9A3	0.639172611350862
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1572	34/9376	1.22795988624457	POLR2L/POLR1F/POLR2I/POLR2G/POLR3E/POLR1C/POLR3GL	0.597628413539158
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	30/1572	166/9376	1.07789938379472	MYLK/KCNMB4/ATP2B4/KCNMA1/ATP2B1/CALM2/GUCY1A1/ADRA1B/MYL9/PDE3A/VDAC2/ADRB2/PPIF/NFATC2/PPP3R1/CALM1/VDAC1/CNGA1/PPP1CB/NFATC3/VDAC3/PPP3CC/ITPR1/GUCY1B1/ATP1B1/ADCY3/GNAI3/RHOA/ATF2/PLCB2	0.45447660276722
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1572	18/9376	1.32541702007351	ACSL3/ACSL1/MCAT/ACSF3	0.620209300656894
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	35/1572	195/9376	1.07052913159783	ACTB/H3-3B/H2AJ/HMGB1/H3-3A/MACROH2A1/CYBA/ACTG1/NCF1/FCGR3B/H2BC12/VDAC2/H2AZ1/CASP4/H2AZ2/PPIF/CLEC7A/H4C3/VDAC1/H2AC20/MACROH2A2/RAC2/VDAC3/PIK3R1/AZU1/C5/FPR1/MAPK13/H2AC8/H2BC11/PLCB2/C5AR1/SYK/H2BC5/VWF	0.446677551886404
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	26/1572	143/9376	1.08443210733287	CD40/H3-3B/H2AJ/H3-3A/MACROH2A1/FCGR3B/H2BC12/H2AZ1/H2AZ2/SSB/H4C3/H2AC20/MACROH2A2/GRIN2B/HLA-DPB1/HLA-DRA/C5/HLA-DQA2/HLA-DRB5/H2AC8/H2BC11/HLA-DMA/HLA-DMB/C7/H2BC5/HLA-DPA1	0.45662271143209
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/1572	46/9376	1.16694324593428	FTH1/FTL/BLVRA/MMAB/EPRS1/BLVRB/CP/UROS/PPOX	0.509401507710318
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/1572	63/9376	1.13607173149158	ERCC6/POLR2L/POLR2I/CETN2/POLD2/DDB2/XPA/POLR2G/POLE3/RPA3/GTF2H5/ERCC1	0.48634747234337
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1572	63/9376	1.13607173149158	WNT5A/WNT2/FZD6/WNT10A/WNT6/DDB2/GADD45G/FZD1/WNT11/BMP2/GADD45B/CDKN1A	0.48634747234337
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	16/1572	86/9376	1.10965145866619	ACTB/ITGA2/ITGB5/ITGB6/ITGB4/ACTG1/ITGA1/LMNA/CDH2/CACNG4/SGCB/ITGA6/ITGB8/CACNA2D3/LAMA2/SNTA1	0.458468034161183
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	7/1572	35/9376	1.19287531806616	PFKP/SORD/ALDOC/TPI1/PFKM/TKFC/HSD17B14	0.513058952443343
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1572	98/9376	1.09549774108117	PLCD1/DGKB/CALM2/PIK3C2G/DGKD/ITPK1/BPNT2/CALM1/INPP4B/PTEN/PIK3R1/CDS1/INPP5F/ITPR1/ITPKB/PIP5K1B/SACM1L/PLCB2	0.426512959142052
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/1572	156/9376	1.07052913159783	CCND1/CDK6/CD81/IRF9/YWHAZ/IRF7/PPP2CA/CLDN3/STAT1/MX2/STAT3/PPP2R2B/KRAS/FAS/PIK3R1/BID/CLDN9/MYC/OAS2/CLDN1/CASP3/YWHAH/CDKN1A/OCLN/YWHAB/CHUK/LDLR/EIF3E	0.398674679617018
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/1572	110/9376	1.08443210733287	TIMP1/EDN1/CAMK2D/GAPDH/PFKP/HIF1A/ELOB/ALDOC/ENO1/PGK1/STAT3/ENO2/PIK3R1/PFKM/VEGFA/IFNGR1/CDKN1B/CDKN1A/IL6/VHL	0.399770830369207
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/1572	180/9376	1.06033361605881	IRF9/BST2/IRF7/STAT1/HLA-A/PPP1CB/TNFSF14/FAS/HLA-DPB1/PIK3R1/BID/TNFRSF14/OAS2/HLA-DRA/BCL2L1/SRSF2/HLA-B/C5/EIF2B3/CASP3/HLA-DQA2/HLA-F/HLA-DRB5/IFNGR1/HLA-DMA/BIRC3/HLA-DMB/CHUK/SYK/IL6/B2M/HLA-DPA1	0.366816958219158
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1572	30/9376	1.19287531806616	ABCC2/FOLR3/TYMS/GGH/CHUK/IL6	0.474873213759473
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	40/1572	227/9376	1.05099146966181	CCND1/CDK6/CALM2/CXCL8/CDKN2A/PRKACB/CCL3L1/PRKACA/AKAP13/NFATC2/PPP3R1/CALM1/HLA-A/STAT3/RAC2/KRAS/NFATC3/FAS/PIK3R1/PPP3CC/BID/MYC/PTGS2/HLA-B/CRK/CASP3/ITPR1/HLA-F/MAPK13/VEGFA/ADCY3/GNAI3/CDKN1A/RHOA/ATF2/CHUK/PLCB2/IL6/B2M/CCR3	0.349041384584894
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1572	99/9376	1.08443210733287	CAMK2D/PLA2G4A/CALM2/NGF/MAP2K3/PRKACB/PRKACA/P2RY2/TRPV3/CALM1/PPP1CB/HRH1/PIK3R1/ITPR1/MAPK13/ADCY3/PRKCD/PLCB2	0.379030995924402
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1572	36/9376	1.15973989256432	GALNT13/GALNT5/B3GNT3/B4GALT5/GALNTL6/ST3GAL1/C1GALT1	0.430967458779685
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1572	82/9376	1.09104449823124	MGST1/DPYD/GSTP1/NME3/GSTO2/NME7/IMPDH1/NME1/HPRT1/RRM2B/TPMT/UPP1/TK1/GMPS/RRM1	0.371631550723322
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	32/1572	181/9376	1.054475419285	CAMK2D/HSPD1/CALM2/ATP6V0C/FCGR3B/CTSS/CLEC7A/STAT1/PPP3R1/CALM1/ITGAX/CORO1A/HLA-DPB1/PPP3CC/BID/HLA-DRA/RIPK2/PLA2R1/EEA1/CASP3/HLA-DQA2/HLA-DRB5/MAPK13/NOD2/IFNGR1/HLA-DMA/RHOA/HLA-DMB/ATP6AP1/SYK/IL6/HLA-DPA1	0.332137017068031
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	28/1572	158/9376	1.05697812993204	CCND1/CCND2/SFN/CDK6/CDKN2A/CDC25B/YWHAZ/PPP2CA/CCND3/GADD45G/PPP2R5C/GADD45B/ANAPC16/MYC/ABL1/CDKN2C/CDC26/YWHAH/CDKN1B/CDKN1A/RAD21/PTTG1/CHEK1/YWHAB/ANAPC15/TFDP1/ANAPC11/ANAPC10	0.324169134523435
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1572	158/9376	1.05697812993204	WNT5A/WNT2/FZD6/WNT10A/FNIP2/ATP6V1B2/WNT6/RPS6KA2/PRR5L/SLC7A5/FZD1/WNT11/FNIP1/PTEN/ATP6V1F/KRAS/PIK3R1/LAMTOR4/FLCN/CAB39L/LAMTOR5/LRP5/LAMTOR2/AKT1S1/TBC1D7/RHOA/CHUK/PRKAA2	0.324169134523435
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1572	31/9376	1.15439546909628	GRHPR/ACAT2/DLD/MDH1/MDH2/ACSS1	0.386437286667274
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	37/1572	212/9376	1.04095251812377	THBS1/ACTB/CALM2/NGF/MAGI2/PFN2/RRAS/ACTG1/MAP2K3/MET/PDGFA/EFNA5/RAP1A/EPHA2/RASSF5/RAPGEF6/CALM1/PFN4/GRIN2B/RAC2/KRAS/PIK3R1/PRKD1/F2R/PDGFD/CRK/RALGDS/FPR1/MAPK13/VEGFA/ADCY3/GNAI3/RHOA/RAP1B/KITLG/PRKD2/PLCB2	0.270681939775648
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1572	101/9376	1.06295820421737	WNT5A/WNT2/EDN1/CAMK2D/CALM2/FZD6/WNT10A/PRKACB/WNT6/PRKACA/CALM1/FZD1/WNT11/KRAS/ADCY3/GNAI3/KITLG/PLCB2	0.285502120626417
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1572	37/9376	1.12839557114366	PNMT/TH/COMT/FAH/MAOB/GOT1/FAHD1	0.35119958700978
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1572	43/9376	1.10965145866619	ACSL3/ACSL1/ACAT2/ECI2/ECHS1/ACOX1/GCDH/ACAA1	0.323438181780179
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1572	55/9376	1.08443210733287	CERS6/B4GALT5/SGMS1/SAMD8/B4GALT6/CERK/SGMS2/ASAH1/KDSR/SMPD1	0.28184543068412
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1572	26/9376	1.14699549814054	PLAAT2/PLA2G4A/ACOX1/PLB1/ACAA1	0.336851264173663
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/1572	73/9376	1.06214925581233	CCND1/CDK6/CDKN2A/MET/PDGFA/DDB2/GADD45G/PTEN/KRAS/GADD45B/PIK3R1/PDGFD/CDKN1A	0.239242940130191
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	29/1572	168/9376	1.02956500666424	CCND1/CCND2/IRF9/PRL/PDGFA/CLCF1/STAT1/CCND3/IL4R/GHR/IL22RA1/STAT3/PIAS2/STAM/PIK3R1/SOCS1/MYC/SOCS6/BCL2L1/PRLR/IFNLR1/IFNGR1/OSMR/SOCS5/CDKN1A/LEPR/CTF1/IL2RG/IL6	0.173541459453321
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1572	103/9376	1.04231823908693	COL3A1/LAMB3/COL1A2/COL4A5/COL4A6/LAMC2/CXCL8/GNA15/COL1A1/PRKACB/PRKACA/CXCL2/PIK3R1/CASP3/HSPB1/LAMA2/PLCB2/IL6	0.193815876263271
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/1572	174/9376	1.02834079143634	HSP90AB1/FBXO2/CRYAB/HSP90AA1/HSPA1A/BAG1/SEC61B/UBE2D1/MARCHF6/HSPH1/EIF2AK3/DNAJB1/DAD1/ERO1B/ERN1/HSPA8/SVIP/PRKN/NFE2L2/STUB1/SEC61G/VCP/TMEM258/CAPN2/UBQLN1/UBE2D2/ATF6/DNAJC3/UFD1/DNAJB11	0.169355288269548
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1572	50/9376	1.07358778625954	CKB/ODC1/SMOX/SAT2/MAOB/SMS/ALDH4A1/GAMT/GOT1	0.234151159945963
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1572	62/9376	1.05819584667159	SOD2/CRYAB/HSPA1A/PRKACB/PRKACA/KRAS/PIK3R1/HSPA8/ADCY3/AKT1S1/PRKAA2	0.206335045275131
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1572	15/9376	1.19287531806616	AK4/THTPA/ALPP	0.335516931185456
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	27/1572	157/9376	1.02572081489765	THBS1/CAMK2D/GAS6/ITGB5/PBX1/ATP11B/HIF1A/ODC1/ADAM17/AXL/P2RY2/NFATC2/ALOX5/VPS11/CD36/XKR6/NFATC3/PTGS2/MAPKAPK2/CD47/CRK/CASP3/SIRPA/MAPK13/MFGE8/DUSP8/DUSP5	0.145863261911256
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1572	27/9376	1.10451418339459	OXCT1/ACAT2/ECHS1/ABAT/HMGCL	0.244077537184056
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1572	33/9376	1.08443210733287	VAMP2/STX19/STX11/SEC22B/VAMP5/STX4	0.218059344948287
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1572	63/9376	1.04139908720061	ACAT2/ECHS1/KMT2A/SETD2/DLD/TMLHE/CAMKMT/GCDH/KMT2E/BBOX1/EZH2	0.147968583897879
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	11/1572	63/9376	1.04139908720061	PLAAT2/PTGDS/PLA2G4A/GGT5/ALOX5/PTGR3/LTA4H/LTC4S/PTGS2/PLB1/PTGES3	0.147968583897879
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1572	200/9376	1.01394402035623	MYH14/ACTB/FYN/TUBA4A/GAPDH/TUBA1A/CXCL8/ACTG1/NFKBIB/CLDN3/CASP4/EZR/JUN/ARPC3/BRK1/NAIP/TMED10/WASF3/FAS/CYTH4/MYO5A/CLDN9/MYO5B/NCL/NCKAP1L/F2R/ABL1/CLDN1/CASP3/MAPK13/RHOA/OCLN/CHUK/IL6	0.0894601417924137
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/1572	99/9376	1.02418587914771	DGKB/PLA2G4A/HIF1A/CHPT1/PDGFA/DGKD/JUN/SLC44A3/RAC2/GPCPD1/KRAS/WASF3/PIK3R1/SLC44A1/PDGFD/RALGDS/PIP5K1B	0.108574784525072
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	20/1572	117/9376	1.0195515539027	ACTB/H2AJ/MACROH2A1/ACTG1/H2AZ1/H2AZ2/MEAF6/GATAD2B/H2AC20/POLE3/MACROH2A2/BAZ1A/SMARCA5/DPF3/CDK2AP1/RBBP4/H2AC8/PHF10/RUVBL2/ARID1B	0.0955092527286078
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1572	52/9376	1.03229594832648	PLA2G4A/PRKACB/PRKACA/HSD3B1/ALOX5/HSD17B7/PTGS2/ADCY3/LDLR	0.104809792122683
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/1572	94/9376	1.01521303665205	S100A8/HSP90AB1/S100A9/IL17RC/CXCL8/JUND/HSP90AA1/MMP1/CXCL2/JUN/FOSL1/PTGS2/CASP3/MAPK13/CHUK/IL6	0.0665292051881079
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	26/1572	154/9376	1.00697267109481	MMAB/ADSS2/EPRS1/NQO1/GGCX/GCH1/NME3/BCAT2/MTHFD2L/NME7/BCAT1/NME1/GPHN/COQ4/AK4/COQ3/UROS/AK3/GGH/COQ5/ALPP/PPCS/DLD/PPOX/NADK/KMO	0.0391561749181498
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1572	10/9376	1.19287531806616	BPNT2/ETHE1	0.273875294282469
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/1572	149/9376	1.00073432723671	AVPR1A/FYN/AGPAT2/DGKB/PLA2G4A/CXCL8/RRAS/PDGFA/DGKD/AGPAT3/PTGFR/KRAS/PIK3R1/CYTH4/F2R/GRM7/PDGFD/AGPAT5/RALGDS/ADCY3/RHOA/PIP5K1B/KITLG/PLCB2/SYK	0.00405513941134792
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/1572	125/9376	1.00201526717557	CERS6/FYN/PPP2CA/SGMS1/PPP2R2B/RAC2/PPP2R5C/PTEN/KRAS/S1PR3/PIK3R1/BID/SGMS2/ORMDL2/MAPK13/ASAH1/GNAI3/SPTSSA/RHOA/PLCB2/SMPD1	0.0101799718231293
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1572	65/9376	1.00935603836367	AGPAT2/DGKB/MBOAT2/LPL/DGKD/MBOAT1/AGPAT3/DGAT1/TKFC/GPAT3/AGPAT5	0.0339706445876192
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/1572	65/9376	1.00935603836367	PBX1/PRKACB/PRKACA/HSD3B1/NR4A1/ITPR1/ADCY3/NCEH1/ATF2/LDLR/PLCB2	0.0339706445876192
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1572	59/9376	1.01091128649674	PLAAT2/PRKACB/PRKACA/ADRB2/CIDEC/PIK3R1/PTGS2/ABHD5/ADCY3/GNAI3	0.0377326403332114
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/1572	108/9376	0.994062765055131	SAP18/EIF4A3/THOC7/NUP214/SUMO3/SUMO1/SRRM1/SUMO2/KPNB1/RANBP17/POM121C/RNPS1/NUP37/XPO6/PHAX/RAN/UPF3A/RANBP2	-0.0278519995055748
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1572	23/9376	1.03728288527492	GLS/GLUD1/GOT1/NAGS	0.0803435919527194
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/1572	23/9376	1.03728288527492	FKRP/POMGNT2/ST3GAL3/FUT4	0.0803435919527194
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1572	17/9376	1.05253704535249	CA5B/CA13/GLUD1	0.0973035444430291
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/1572	133/9376	0.986588608926897	CCND1/CCND2/SOD2/BCL2L11/BCL6/GABARAPL2/GADD45G/BNIP3/STAT3/PTEN/KRAS/GADD45B/PIK3R1/USP7/MAPK13/CDKN1B/CDKN1A/TGFBR1/SGK3/CHUK/IL6/PRKAA2	-0.0699111505129323
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1572	103/9376	0.984411670248771	COL3A1/COL7A1/KCNN4/COL1A2/COL4A5/COL4A6/COL12A1/PRSS3/COL9A3/COL5A2/COL1A1/SLC1A1/ACE2/COL6A2/ATP1B1/SLC9A3/COL6A3	-0.0713939392423375
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1572	42/9376	0.994062765055131	ACAT2/ECHS1/KYAT3/MAOB/DLD/GCDH/KMO	-0.017307257711567
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/1572	30/9376	0.994062765055131	PIGP/PGAP4/PGAP2/PIGC/PIGT	-0.0146179089547772
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1572	61/9376	0.977766654152588	FTH1/ATP2B4/FTL/ATP2B1/MT2A/ATOX1/STEAP1/MT1E/ATP1B1/SLC9A3	-0.0781864671882168
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	37/1572	226/9376	0.976468733815218	EDN1/CAMK2D/ATP2B4/PDE4D/SOX9/ATP2B1/CALM2/MYL9/RRAS/EDN2/PRKACB/CAMK4/PDE3A/PRKACA/ADRB2/RAP1A/HCAR3/JUN/CALM1/ACOX1/SSTR1/CNGA1/GRIN2B/RAC2/PDE4B/PPP1CB/OXTR/HTR1B/PIK3R1/F2R/ATP1B1/ADCY3/GNAI3/GABBR1/RHOA/RAP1B/HTR1F	-0.160709758257341
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1572	86/9376	0.970945026332919	KCNN4/KCNMB4/CAMK2D/KCNMA1/RIMS2/PCLO/PRKACB/PRKACA/TRPM4/VAMP2/ATP1B1/ADCY3/ATF2/PLCB2	-0.121482895182483
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1572	80/9376	0.969211195928753	GAS6/MET/AXL/PDGFA/BCL2L11/STAT3/PTEN/KRAS/PIK3R1/PDGFD/BCL2L1/VEGFA/IL6	-0.124120362302944
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1572	18/9376	0.994062765055131	MMAB/TCN2/MMADHC	-0.0113157213847045
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/1572	105/9376	0.965660971767842	CD40/CXCL8/CYLD/CXCL2/GADD45G/PARP1/TNFSF14/GADD45B/PTGS2/BCL2L1/BCL2A1/ICAM1/EDARADD/BIRC3/BLNK/CHUK/SYK	-0.158808095854285
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1572	37/9376	0.967196203837425	ADSS2/ABAT/GLS/ALDH4A1/GLUD1/GOT1	-0.0897280144636664
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1572	154/9376	0.968242952975777	CAMK2D/ATP2B4/ATP2B1/CALM2/ADRA1B/PRKACB/PPP2CA/PRKACA/ADRB2/TPM2/CACNG4/CALM1/PPP2R2B/PPP2R5C/PPP1CB/MYL4/TNNC1/MAPK13/ATP1B1/ADCY3/CACNA2D3/GNAI3/ATF2/PLCB2/CREM	-0.178336891451859
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/1572	99/9376	0.963939650962552	CCND1/CDKN2A/PRKACB/PRKACA/BIK/JUN/NOTCH2/KRAS/PIK3R1/HBEGF/CDKN2C/MAPK13/ADCY3/CDKN1B/CDKN1A/JAG1	-0.161881426874258
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1572	93/9376	0.961996224246901	CAMK2D/PLA2G4A/CALM2/MAP2K3/PRKACB/PRKACA/JUN/CALM1/KRAS/HBEGF/ITPR1/MAPK13/ADCY3/PRKCD/PLCB2	-0.165301701740196
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/1572	130/9376	0.963476218438051	COL3A1/EDN1/COL1A2/COL4A5/COL4A6/GNA15/COL1A1/PRKACB/PRKACA/MMP1/JUN/ACTA2/KRAS/PIK3R1/MAPK13/VEGFA/ADCY3/GNAI3/ATF2/TGFBR1/PLCB2	-0.188201788832449
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1572	31/9376	0.961996224246901	DPYD/ECHS1/SMOX/ACOX1/ABAT	-0.0951198637570163
NA	NA	hsa04981	Folate transport and metabolism	5/1572	31/9376	0.961996224246901	ABCC2/FOLR3/TYMS/SLCO1B3/ST20-MTHFS	-0.0951198637570163
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/1572	38/9376	0.941743672157493	CD40/UNG/PTPRC/IL2RG/BLNK/CD3D	-0.161495805820738
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/1572	144/9376	0.952643483177834	RORA/SPTBN2/VDAC2/PPIF/VDAC1/GRIN2B/VDAC3/PIK3R1/ERN1/PSMA7/ITPR1/PSMD6/PSMB1/OMA1/PSMC5/PSMB6/RB1CC1/PSMD12/GTF2B/PSMC6/PSMD9/PLCB2/PSMC1	-0.257019679912432
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/1572	107/9376	0.947611233977789	CAMK2D/CALM2/PFKP/PRKACB/PRKACA/PPP3R1/CALM1/PFKM/PPP3CC/PPP4R3A/PGAM4/PGAM1/ITPR1/ATF2/PKM/PLCB2/PRKAA2	-0.244605881608735
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1572	51/9376	0.935588484757771	PLAAT2/PLA2G4A/CHPT1/PEDS1/LPCAT2/PLB1/PAFAH1B3/PAFAH1B1	-0.207003392161294
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	27/1572	169/9376	0.952888567685984	HMGB1/RPS27A/HIF1A/UBA52/RRAS/OPTN/UBB/PRKACB/MAP1LC3A/PPP2CA/PRKACA/TANK/GABARAPL2/VPS11/BNIP3/EIF2AK3/PTEN/KRAS/PIK3R1/ERN1/BCL2L1/ITPR1/PRKCD/RB1CC1/AKT1S1/ATG9B/PRKAA2	-0.27737279805785
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1572	163/9376	0.951372953058899	CXCL8/MAP2K3/YWHAZ/IRF7/DDB2/JUN/STAT1/NFATC2/STAT3/KRAS/NFATC3/FAS/VDAC3/PIK3R1/BID/MYC/EGR2/CASP3/MAPK13/CDKN1A/ATF2/TGFBR1/YWHAB/CHUK/ATP6AP1/IL6	-0.2810764382035
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1572	26/9376	0.917596398512429	AMN/TCN2/CUBN/PLB1	-0.188834064203878
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1572	102/9376	0.935588484757771	ATP2B4/KCNMA1/ATP2B1/RAB27B/BST1/PRSS3/RAP1A/SLC12A2/ITPR1/ATP1B1/ADCY3/TRPC1/RHOA/RAP1B/PLCB2/RAB3D	-0.293550844818686
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/1572	103/9376	0.926505101410608	CXCL8/GNA15/CCL3L1/PPP2CA/JUN/PPP2R2B/FAS/PIK3R1/MAPK13/IFNGR1/GNAI3/TGFBR1/CHUK/PLCB2/IL6/CD3D	-0.336603754747946
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1572	78/9376	0.917596398512429	ACTB/CAV1/ACTG1/CAV2/SEPTIN1/CD2AP/MET/ARPC3/SEPTIN6/PIK3R1/CRK/RHOA	-0.32798350470816
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/1572	78/9376	0.917596398512429	CALM2/CXCL8/JUN/CALM1/CFL1/IRF1/C5/CASP3/MAPK13/GNAI3/RHOA/IL6	-0.32798350470816
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/1572	122/9376	0.928878321444959	FYN/PPP2CA/NFKBIB/JUN/NFATC2/PPP3R1/PPP2R2B/PPP2R5C/KRAS/NFATC3/PIK3R1/PPP3CC/PTPRC/NFKBIE/MAPK13/RHOA/TEC1/CHUK/CD3D	-0.354870946122639
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/1572	122/9376	0.928878321444959	CCND1/ACTB/PLCD1/PFKP/HIF1A/KAT2B/ACTG1/PRKACB/PRKACA/STAT1/NOTCH2/KRAS/PIK3R1/PFKM/MYC/ATP1B1/DIO3/PLCB2/THRA	-0.354870946122639
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1572	59/9376	0.90982015784707	CCND1/DDB2/GADD45G/PTEN/KRAS/GADD45B/PIK3R1/MYC/CDKN1A	-0.311853561014801
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	11/1572	72/9376	0.911224201300537	CXCL8/IRF7/CYLD/NFKBIB/TANK/PIN1/ZNFX1/TKFC/MAPK13/RNF125/CHUK	-0.339374544711051
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1572	53/9376	0.900283258917855	ATP2B4/ATP2B1/AP2S1/PRKACB/PRKACA/ATP1B1/AP2A1/PLCB2	-0.326724308854462
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/1572	86/9376	0.901591810166282	EREG/CAMK2D/AREG/ABL2/JUN/KRAS/PIK3R1/HBEGF/MYC/ABL1/CRK/CDKN1B/CDKN1A	-0.411458359854316
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1572	21/9376	0.852053798618684	CSGALNACT2/CHSY3/CHST3	-0.304610485605713
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/1572	100/9376	0.894656488549618	CXCL8/CCL3L1/XCL1/CXCL2/XCL2/IL22RA1/TNFRSF10C/TNFSF14/TNFRSF14/CCL27/CXCL14/IL18R1/IL2RG/IL6/CCR3	-0.475314101967073
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/1572	68/9376	0.87711420446041	CCND1/DUSP6/RARA/STAT3/ZBTB16/KRAS/PIK3R1/MYC/BCL2A1/CHUK	-0.456437410788433
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/1572	62/9376	0.865796601822211	KAT2B/ADAM17/HES1/NUMB/NOTCH2/RFNG/PSEN1/CTBP1/JAG1	-0.475822001445471
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1572	49/9376	0.852053798618684	GALNT13/GALNT5/GALNTL6/RFNG/C1GALT1/OGT/ST3GAL3	-0.465998103434548
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/1572	133/9376	0.896898735388089	CAMK2D/TH/CALM2/PRKACB/PPP2CA/PRKACA/CALM1/KIF5B/GRIN2B/PPP2R2B/PPP2R5C/PPP1CB/PPP3CC/COMT/MAOB/ITPR1/MAPK13/GNAI3/ATF2/PLCB2	-0.537448202730657
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1572	29/9376	0.822672633149074	RASSF2/FAT4/YAP1/RASSF1	-0.429231831604219
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/1572	29/9376	0.822672633149074	CALM2/CALM1/RGS9/CNGA1	-0.429231831604219
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1572	36/9376	0.828385637545943	ENPP1/MGAM/GPI/PGM2L1/GYG1	-0.463003977839414
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1572	89/9376	0.871201074992138	TUBA4A/TUBA1A/GUCY1A1/PRKACB/PRKACA/PDGFA/KRAS/PDGFD/ITPR1/GUCY1B1/ADCY3/GNAI3/PLCB2	-0.547927121118127
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1572	83/9376	0.862319507035777	POLR2L/ZDHHC1/IRF7/NFKBIB/SAMHD1/POLR3E/POLR1C/POLR3GL/CASP3/MLKL/CHUK/IL6	-0.565440313499641
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1572	70/9376	0.852053798618684	ACSL3/ADIPOR2/ACSL1/NFKBIB/STAT3/CD36/NFKBIE/LEPR/CHUK/PRKAA2	-0.557602347455557
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/1572	122/9376	0.879989988737329	MAP2K3/PRKACB/PRKACA/STAT1/JUNB/GHR/SSTR1/STAT3/KRAS/PIK3R1/SOCS1/CRK/ITPR1/MAPK13/ADCY3/GNAI3/ATF2/PLCB2	-0.598805696184653
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1572	90/9376	0.86152106304778	SOD2/ADIPOR2/SESN3/PRKACB/CAMK4/PRKACA/KRAS/PIK3R1/ADCY3/RB1CC1/AKT1S1/ATF2/PRKAA2	-0.592439374474648
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	22/1572	148/9376	0.886596520184306	WNT5A/CCND1/WNT2/CDK6/FZD6/WNT10A/WNT6/DDB2/HES1/JUN/GADD45G/FZD1/WNT11/NOTCH2/PTEN/KRAS/GADD45B/PIK3R1/MYC/LRP5/CDKN1A/JAG1	-0.62410365309633
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1572	37/9376	0.805996836531188	HBB/FAS/ICAM1/PLCB2/IL6	-0.530655615937113
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/1572	44/9376	0.813324080499653	DAD1/TMEM258/ST3GAL3/MGAT2/B4GALNT3/ALG14	-0.55703252088637
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1572	16/9376	0.745547073791349	MAOB/GOT1	-0.457175338660152
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/1572	78/9376	0.841130031969727	PLCD1/PIK3C2G/TPI1/ITPK1/INPP4B/PTEN/INPP5F/ITPKB/PIP5K1B/SACM1L/PLCB2	-0.63233557716894
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1572	66/9376	0.813324080499653	CYP7B1/SULT2B1/HSD17B12/HSD11B1/HSD3B1/SRD5A3/HSD11B1L/HSD17B7/COMT	-0.683028310891456
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1572	39/9376	0.764663665427024	MTHFD2L/TYMS/CTH/DLD/ST20-MTHFS	-0.660953471137811
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1572	60/9376	0.795250212044105	PLA2G4A/GUCY1A1/PPP2CA/KRAS/ITPR1/GUCY1B1/GNAI3/PLCB2	-0.714064799454106
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1572	140/9376	0.852053798618684	CCND1/MYLK/CALM2/RRAS/PRKACB/CAMK4/MAP1LC3A/PRKACA/CALM1/ACTA2/KRAS/MYL4/ITPR1/ADCY3/GNAI3/CCN2/TGFBR1/PLCB2/JAG1/PRKAA2	-0.79155145810785
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1572	54/9376	0.773159928376213	HES1/FANCL/RPA3/RMI2/CENPS/ERCC1/FANCF	-0.750266205897122
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/1572	115/9376	0.829826308219936	CAMK2D/SLC18A3/FYN/PRKACB/ACHE/CHAT/CAMK4/PRKACA/KCNQ3/KCNQ5/KRAS/PIK3R1/ITPR1/ADCY3/GNAI3/PLCB2	-0.824072985353857
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/1572	75/9376	0.795250212044105	GPX1/PRKACB/PRKACA/ITPR1/TTF1/ATP1B1/ADCY3/ATF2/PLCB2/DUOX1	-0.798992217003856
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1572	18/9376	0.662708510036754	MANBA/FUCA1	-0.642840743426303
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1572	89/9376	0.80418560768505	GABRP/PRKACB/PRKACA/TRAK2/GABARAPL2/ABAT/SLC38A5/GPHN/GLS/ADCY3/GNAI3/GABBR1	-0.833019501118324
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1572	69/9376	0.77796216395619	FYN/PLA2G4A/MAP2K3/ALOX5/RAC2/KRAS/PIK3R1/MAPK13/SYK	-0.830806629167626
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1572	41/9376	0.727362998820828	POLD2/RAD51B/NBN/RPA3/ABRAXAS1	-0.785186532670273
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1572	97/9376	0.79934943994124	CAMK2D/CALM2/GUCY1A1/PRKACB/PER3/PRKACA/CALM1/GRIN2B/ITPR1/GUCY1B1/ADCY3/GNAI3/PLCB2	-0.891515574860042
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1572	19/9376	0.627829114771662	BCKDHB/DLD	-0.72879294505398
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/1572	106/9376	0.787747851553123	HSP90AB1/CCND1/SPINT1/HSP90AA1/FOLR3/PDGFA/GSTP1/PTEN/KRAS/PIK3R1/PDGFD/CDKN1B/CDKN1A/CHUK	-0.986321361758878
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	34/1572	238/9376	0.852053798618684	PLAAT2/PLA2G4A/CALM2/NGF/RRAS/ETS1/PRKACB/MET/PRKACA/PDGFA/EFNA5/ABL2/RAP1A/EPHA2/RASSF5/NTF4/CALM1/GRIN2B/RAC2/SYNGAP1/KRAS/PIK3R1/PDGFD/RALGAPA1/BCL2L1/ABL1/RALGDS/RIN1/VEGFA/RASSF1/RHOA/RAP1B/KITLG/CHUK	-1.03757619494253
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1572	28/9376	0.639040348964013	ATP6V0C/ATP6V1B2/ATP6V1F	-0.858482804473714
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1572	20/9376	0.596437659033079	CYB5R1/CYB5R3	-0.810837456341244
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	27/1572	193/9376	0.834394652533323	CXCL8/NCF1/PRKACB/CCL3L1/XCL1/PRKACA/NFKBIB/RAP1A/CXCL2/STAT1/XCL2/STAT3/RAC2/KRAS/PIK3R1/CCL27/CRK/CXCL14/PREX1/ADCY3/PRKCD/GNAI3/RHOA/RAP1B/CHUK/PLCB2/CCR3	-1.04331150673327
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	43/1572	298/9376	0.86063152142357	CD40/IL36RN/IL17RC/CXCL8/NGF/IL1RL2/IL1RN/BMPR1A/TNFSF12/CCL3L1/PRL/XCL1/CLCF1/CXCL2/XCL2/ACVR2A/IL4R/GHR/IL22RA1/IL32/BMP2/TNFRSF10C/TNFSF14/FAS/TNFRSF14/TNFRSF18/TNFRSF21/ACVR1B/CCL27/CXCL14/PRLR/IFNLR1/IFNGR1/OSMR/TNFRSF6B/LEPR/CTF1/IL18R1/TNFSF13/IL2RG/TGFBR1/IL6/CCR3	-1.09731390005545
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1572	44/9376	0.677770067083044	GTF2F2/TAF13/GTF2H5/TAF7/GTF2B	-0.961519580662593
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1572	30/9376	0.596437659033079	PLAAT2/PLA2G4A/PLB1	-0.993600154383277
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/1572	144/9376	0.786966355668646	WNT5A/HAND1/WNT2/MEIS1/FZD6/ID4/WNT10A/BMPR1A/PCGF5/WNT6/ACVR2A/FZD1/WNT11/STAT3/KRAS/PIK3R1/MYC/ACVR1B/MAPK13	-1.15620494814339
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1572	191/9376	0.811904666746599	TH/H3-3B/H2AJ/H3-3A/MACROH2A1/CALM2/H2BC12/PRKACB/CAMK4/H2AZ1/PRKACA/H2AZ2/CALM1/H4C3/CAMKK1/H2AC20/MACROH2A2/GRIN2B/PPP1CB/KRAS/MAOB/H2AC8/H2BC11/GNAI3/ATF2/H2BC5	-1.17871389351818
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1572	68/9376	0.701691363568328	CYP26B1/DHRS4L2/ALDH1A3/PNPLA4/DGAT1/CYP27C1/ALDH1A2/CYP2W1	-1.10801432363136
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1572	90/9376	0.72897936104043	ABCC2/PRKACB/PRKACA/SLC27A5/HMGCR/SLCO1B3/ATP1B1/ADCY3/SLC9A3/NCEH1/LDLR	-1.15947812244058
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1572	23/9376	0.51864144263746	POLD2/RPA3	-1.03731444684357
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1572	23/9376	0.51864144263746	ACE2/ANPEP	-1.03731444684357
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1572	32/9376	0.559160305343511	PFKP/MGAM/PFKM	-1.121095336157
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/1572	32/9376	0.559160305343511	PPP2CA/GABARAPL2/ATG9B	-1.121095336157
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/1572	56/9376	0.639040348964013	DAD1/SRD5A3/DPM3/TMEM258/MGAT2/ALG14	-1.21590037981135
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/1572	56/9376	0.639040348964013	CCND1/CCND2/PRKACB/PRKACA/SMURF2/CDON	-1.21590037981135
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1572	79/9376	0.679485940670596	SLC18A3/AP2S1/ATP6V0C/ATP6V1B2/VAMP2/SLC1A1/ATP6V1F/UNC13B/AP2A1	-1.28393339045165
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/1572	122/9376	0.733324990614441	CCND1/PFKP/ADIPOR2/PPP2CA/PPP2R2B/PPP2R5C/CD36/SCD5/PIK3R1/PFKM/HMGCR/CAB39L/LEPR/AKT1S1/PRKAA2	-1.33060994637069
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1572	115/9376	0.726098019692444	PLA2G4A/PRKACB/PRKACA/ALOX5/KRAS/HTR1B/PTGS2/MAOB/CASP3/ITPR1/GNAI3/TRPC1/PLCB2/HTR1F	-1.32638141798146
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1572	150/9376	0.7554877014419	WNT5A/CCND1/WNT2/FZD6/WNT10A/MET/WNT6/DDB2/GADD45G/FZD1/WNT11/KRAS/GADD45B/PIK3R1/MYC/LRP5/CDKN1B/CDKN1A/TGFBR1	-1.35485522763603
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/1572	65/9376	0.6423174789587	KCNN4/KRAS/PIK3R1/ITPR1/GABBR1/TRPC1/PLCB2	-1.29870200668233
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1572	15/9376	0.397625106022053	ST3GAL1	-1.04786334444992
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1572	116/9376	0.71983855400544	PLA2G4A/PRKACB/PRKACA/PPP3R1/SLC1A1/GRIN2B/PPP3CC/GRM7/GLS/ITPR1/ADCY3/GNAI3/TRPC1/PLCB2	-1.36265260320328
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/1572	138/9376	0.734742043736402	ACTB/CXCL8/ACTG1/MAP2K3/RPS6KA2/JUN/NFATC2/ARPC3/RAC2/NFATC3/PIK3R1/CRK/MAPK13/RHOA/PIP5K1B/CHUK/IL6	-1.40887434902444
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1572	103/9376	0.694878826057956	PPP2CA/SAP18/EIF4A3/PPP2R2B/PPP2R5C/PPP1CB/PABPC1/GSPT2/SRRM1/RNPS1/ETF1/UPF3A	-1.39744301677038
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1572	43/9376	0.554825729333097	AGPAT2/ACAT2/DGAT1/CD36	-1.31312759931586
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1572	16/9376	0.372773536895674	ST3GAL1	-1.12693720979727
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1572	36/9376	0.497031382527566	POLD2/POLE3/RPA3	-1.35697541445851
NA	NA	hsa04519	Cadherin signaling	56/1572	404/9376	0.826745269946842	VIM/KRT6A/KRT5/WNT5A/DSG1/GABRP/DSC3/KRT24/WNT2/KRT17/PCDH7/KRT16/ACTB/PKP1/PCDH9/KRT14/CDH10/CDH11/PRICKLE1/FZD6/RRAS/ACTG1/WNT10A/MAP2K3/YWHAZ/DSG3/MET/WNT6/KRT6C/CIB2/CDH2/ARPC3/BRK1/FZD1/WNT11/KRT13/RAC2/PPP1CB/PSEN1/KRAS/KRT10/NCKAP1L/LRP5/FAT4/KRT86/KRT78/MAPK13/KRT27/YAP1/YWHAH/RHOA/YWHAB/CHUK/TMC6/LHFPL2/PKP3	-1.59766024614107
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1572	17/9376	0.350845681784164	GGT5	-1.20229479273338
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1572	45/9376	0.530166808029403	ABCC2/ABCA12/ABCD3/ABCB7	-1.41787888702295
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1572	70/9376	0.596437659033079	MGST1/HSD11B1/GSTP1/GSTO2/HSD11B1L/PTGS2/SULT1A3	-1.52100768094634
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1572	109/9376	0.656628615449261	CD40/CXCL8/IRF9/MAP2K3/IRF7/CCL3L1/JUN/STAT1/PIK3R1/MAPK13/CHUK/IL6	-1.61830749605391
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/1572	109/9376	0.656628615449261	SLC27A6/RPS6KA2/SLC27A5/STAT3/PPP1CB/CD36/PTEN/PIK3R1/PRKCD/OGT/IL6/PRKAA2	-1.61830749605391
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1572	47/9376	0.507606518326025	PIK3R1/SOCS1/PRKCD/PKM	-1.51878729743919
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1572	48/9376	0.497031382527566	MGAM/PIK3R1/ATP1B1/PLCB2	-1.56790778664548
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/1572	91/9376	0.589883399043704	GABRP/PDE4D/PRKACB/PDE3A/PRKACA/PDE4B/ADCY3/GNAI3/GABBR1	-1.76437286553528
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1572	144/9376	0.662708510036754	CCND1/IL17RC/CXCL8/ADIPOR2/MAP2K3/CXCL2/ACOX1/FAS/SCD5/C5/CASP3/MAPK13/CHUK/C5AR1/IL6/PRKAA2	-1.83059389931661
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1572	22/9376	0.271108026833218	MAOB	-1.53613400793352
NA	NA	hsa04081	Hormone signaling	26/1572	219/9376	0.708099503874888	AVPR1A/ADRA1B/ADIPOR2/GNA15/BMPR1A/RAMP1/PRKACB/PTHLH/PRL/PRKACA/ADRB2/GHR/SSTR1/NPR3/STAT3/UCN2/OXTR/PIK3R1/PENK/PRLR/ADCY3/GNAI3/LEPR/RHOA/PLCB2/THRA	-1.96170438177713
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	41/1572	323/9376	0.757088050165828	VIM/THBS1/CCND1/CCND2/CDK6/SERPINB5/HMGA2/TNC/CDKN2A/CDC25B/CD44/SPRY2/MET/PDGFA/EFNA5/BCL2L11/EZR/STAT3/NOTCH2/PTEN/KRAS/MMP16/PIK3R1/SOCS1/MARCKS/MYC/PTGS2/ZEB2/ABL1/CRK/GLS/CASP3/VEGFA/CCNG1/CDKN1B/CDKN1A/RASSF1/FOXP1/TP63/RHOA/EZH2	-1.99391738373132
Organismal Systems	Sensory system	hsa04742	Taste transduction	8/1572	86/9376	0.554825729333097	SCNN1A/PRKACB/PRKACA/HTR1B/GABBR1/PLCB2/HTR1F/TAS2R20	-1.86133568321348
NA	NA	hsa04082	Neuroactive ligand signaling	23/1572	199/9376	0.689350058178935	GABRP/SLC18A3/TAC3/ADRA1B/PRKACB/ACHE/CHAT/PRKACA/ADRB2/P2RY2/SLC1A1/GRIN2B/HRH1/HTR1B/PENK/GRM7/OGFRL1/SLC17A9/ADCY3/GNAI3/GABBR1/PLCB2/HTR1F	-1.98792835179704
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1572	24/9376	0.248515691263783	HS3ST3B1	-1.65434684394986
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	25/1572	217/9376	0.687140160176358	HSP90AB1/CCND1/MGST1/HSP90AA1/PRKACB/PRKACA/ADRB2/RPS6KA2/BCL6/JUN/CCND3/STAT3/GSTO2/NOTCH2/KRAS/PIK3R1/MYC/KPNB1/PTGES3/VEGFA/AHR/ADCY3/GNAI3/ATF2/JAG1	-2.09270944651816
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1572	36/9376	0.331354255018377	SORD/FGGY	-1.80396113276806
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1572	26/9376	0.229399099628107	HES1	-1.7658900493365
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1572	38/9376	0.313914557385831	GNPDA2/GPI	-1.90193796142446
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1572	79/9376	0.452990627113731	MGST1/HSD11B1/GSTP1/GSTO2/HSD11B1L/AKR7A2	-2.19124115868157
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1572	41/9376	0.290945199528331	GABRP/GRIN2B	-2.04205693962164
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/1572	138/9376	0.561861562857248	CALM2/PRKACB/PRKACA/PPP1R3F/CALM1/PPP1CB/KRAS/PIK3R1/SOCS1/PRKAR1B/CRK/PRKAR2A/PRKAA2	-2.32710081200603
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1572	31/9376	0.19239924484938	HSD17B14	-2.02134846545418
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/1572	37/9376	0.161199367306238	GPI	-2.2943660218309
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/1572	73/9376	0.326815155634564	MGST1/GSTP1/GSTO2/MAOB	-2.59141834141019
Genetic Information Processing	Transcription	hsa03040	Spliceosome	24/1572	243/9376	0.589074231143782	LSM5/HSPA1A/BCAS2/U2AF1/SF3B5/EIF4A3/SF1/THOC7/SF3B6/HSPA8/SRSF2/PPIE/SNRPF/PQBP1/SNRPB2/HNRNPM/SNRPD2/SYF2/LSM4/SF3A1/ZMAT2/RP9/CWC15/PRPF18	-2.91281607763503
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	39/1572	370/9376	0.628677532494326	GABRP/AVPR1A/EDN1/TAC3/LYPD6B/ADRA1B/EDN2/PRSS3/PRL/ADRB2/GZMA/P2RY2/GHR/SSTR1/GRIN2B/PTGFR/HRH1/UCN2/NPFFR2/OXTR/S1PR3/HTR1B/PENK/F2R/GRM7/OGFRL1/C5/GAL/PRLR/FPR1/PTAFR/NR3C1/GABBR1/LEPR/C5AR1/HTR1F/NPW/LTB4R/THRA	-3.270690105843
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1572	183/9376	0.391106661661035	NOP10/POP4/POP5/IMP3/TCOF1/PWP2/GAR1/RPP40/RAN/RPP25L/RCL1/NHP2	-3.73328732769891
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/1572	449/9376	0.13283689510759	CAMK2D/CALM2/OR2T2/OR2T11/OR2T10/PRKACB/PRKACA/OR2G6/CALM1/ADCY3	-8.451318587267