ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 93/2948 175/18639 0.531428571428571 3.36000581508044 2.50094470894568e-30 3.27623756871884e-27 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 36/2948 68/18639 0.529411764705882 3.34725436986192 1.58602018270686e-12 1.03884321967299e-09 GO:0009055 electron transfer activity 45/2948 116/18639 0.387931034482759 2.45272949515744 1.81448530825637e-09 7.9232525127195e-07 GO:0003954 NADH dehydrogenase activity 24/2948 44/18639 0.545454545454545 3.4486863204638 3.74947133501746e-09 9.98573887241107e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity 23/2948 41/18639 0.560975609756098 3.5468196710461 3.81135071466071e-09 9.98573887241107e-07 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 27/2948 58/18639 0.46551724137931 2.94327539418893 3.54403574484395e-08 6.81980579408056e-06 GO:0022853 active monoatomic ion transmembrane transporter activity 43/2948 118/18639 0.364406779661017 2.30399523951889 3.64417103500488e-08 6.81980579408056e-06 GO:0016651 oxidoreductase activity, acting on NAD(P)H 35/2948 88/18639 0.397727272727273 2.51466710867152 5.35291505479401e-08 8.7653984022252e-06 GO:0015078 proton transmembrane transporter activity 58/2948 185/18639 0.313513513513514 1.98221790311343 9.22525658830653e-08 1.34278734785351e-05 GO:0004812 aminoacyl-tRNA ligase activity 20/2948 41/18639 0.48780487804878 3.08419101830096 8.22177652704472e-07 9.79138840948053e-05 GO:0016875 ligase activity, forming carbon-oxygen bonds 20/2948 41/18639 0.48780487804878 3.08419101830096 8.22177652704472e-07 9.79138840948053e-05 GO:0045296 cadherin binding 87/2948 334/18639 0.260479041916168 1.64690259914364 9.11439683301584e-07 9.94988320937562e-05 GO:0016874 ligase activity 49/2948 167/18639 0.293413173652695 1.85513166340318 7.21201384346236e-06 0.000726749087302746 GO:0004129 cytochrome-c oxidase activity 10/2948 15/18639 0.666666666666667 4.21506105834464 1.34268816418069e-05 0.00111464568638799 GO:0055105 ubiquitin-protein transferase inhibitor activity 10/2948 15/18639 0.666666666666667 4.21506105834464 1.34268816418069e-05 0.00111464568638799 GO:0015399 primary active transmembrane transporter activity 48/2948 166/18639 0.289156626506024 1.82821925422177 1.36842233008397e-05 0.00111464568638799 GO:0023023 MHC protein complex binding 17/2948 37/18639 0.459459459459459 2.90497451318347 1.51178711952702e-05 0.00111464568638799 GO:0023026 MHC class II protein complex binding 14/2948 27/18639 0.518518518518518 3.27838082315694 1.53157422557128e-05 0.00111464568638799 GO:0043021 ribonucleoprotein complex binding 50/2948 177/18639 0.282485875706215 1.78604282133247 1.83976606574622e-05 0.00126847028743555 GO:0004857 enzyme inhibitor activity 98/2948 416/18639 0.235576923076923 1.48945667205928 2.1106554939495e-05 0.00138247934853692 GO:0016675 oxidoreductase activity, acting on a heme group of donors 10/2948 16/18639 0.625 3.9516197421981 3.07077679031107e-05 0.00191557980728929 GO:0005201 extracellular matrix structural constituent 47/2948 168/18639 0.279761904761905 1.76882026555534 4.21823272438704e-05 0.00251176584952137 GO:0043022 ribosome binding 34/2948 112/18639 0.303571428571429 1.91935816049622 8.18785577085386e-05 0.00466351785209502 GO:0019843 rRNA binding 23/2948 65/18639 0.353846153846154 2.23722471558292 8.88596344415616e-05 0.00485025504660191 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 11/2948 21/18639 0.523809523809524 3.31183368869936 0.000113968790605192 0.00597196462771205 GO:0098641 cadherin binding involved in cell-cell adhesion 10/2948 18/18639 0.555555555555556 3.51255088195387 0.000123515945250727 0.00622330339532511 GO:0140101 catalytic activity, acting on a tRNA 39/2948 139/18639 0.280575539568345 1.77396454613785 0.000170299256460982 0.00826266762829209 GO:0005518 collagen binding 24/2948 72/18639 0.333333333333333 2.10753052917232 0.000183426076399701 0.00826668438702725 GO:0051082 unfolded protein binding 35/2948 121/18639 0.289256198347107 1.82884880630656 0.000188384421096604 0.00826668438702725 GO:0005528 FK506 binding 7/2948 10/18639 0.7 4.42581411126187 0.000189313382909021 0.00826668438702725 GO:0005178 integrin binding 43/2948 161/18639 0.267080745341615 1.68864247368465 0.000270588943003276 0.0114345650107836 GO:0042171 lysophosphatidic acid acyltransferase activity 11/2948 23/18639 0.478260869565217 3.02384815055159 0.000321160408932937 0.0127490950212772 GO:0071617 lysophospholipid acyltransferase activity 11/2948 23/18639 0.478260869565217 3.02384815055159 0.000321160408932937 0.0127490950212772 GO:0051087 protein-folding chaperone binding 37/2948 134/18639 0.276119402985075 1.74579021446364 0.000348341374107314 0.0134213882376642 GO:0030742 GTP-dependent protein binding 10/2948 20/18639 0.5 3.16129579375848 0.000384296889549445 0.0139975390786282 GO:0004860 protein kinase inhibitor activity 26/2948 84/18639 0.30952380952381 1.95699263423144 0.000384665196053906 0.0139975390786282 GO:0050840 extracellular matrix binding 22/2948 67/18639 0.328358208955224 2.07607484963243 0.000425452777145735 0.0150633280557003 GO:0050786 RAGE receptor binding 7/2948 11/18639 0.636363636363636 4.02346737387443 0.000449260594578187 0.015090548176857 GO:1990948 ubiquitin ligase inhibitor activity 7/2948 11/18639 0.636363636363636 4.02346737387443 0.000449260594578187 0.015090548176857 GO:0016411 acylglycerol O-acyltransferase activity 13/2948 31/18639 0.419354838709677 2.65140937541034 0.000464497108866017 0.0152122803153621 GO:0001786 phosphatidylserine binding 20/2948 59/18639 0.338983050847458 2.14325138559897 0.000480248463804156 0.0153445240874011 GO:0048027 mRNA 5'-UTR binding 11/2948 24/18639 0.458333333333333 2.89785447761194 0.000508543687464476 0.0158617197756777 GO:0019210 kinase inhibitor activity 27/2948 90/18639 0.3 1.89677747625509 0.000521789112362462 0.015896365981275 GO:0001046 core promoter sequence-specific DNA binding 16/2948 44/18639 0.363636363636364 2.29912421364253 0.000723009041518168 0.0215259510088364 GO:0031386 protein tag activity 8/2948 15/18639 0.533333333333333 3.37204884667571 0.000874073531414647 0.0246236510313758 GO:0141047 molecular tag activity 8/2948 15/18639 0.533333333333333 3.37204884667571 0.000874073531414647 0.0246236510313758 GO:0043236 laminin binding 12/2948 29/18639 0.413793103448276 2.6162447948346 0.000883443968301269 0.0246236510313758 GO:0005527 macrolide binding 7/2948 12/18639 0.583333333333333 3.68817842605156 0.000930855086783428 0.0254045867434644 GO:0019838 growth factor binding 36/2948 136/18639 0.264705882352941 1.67362718493096 0.00097440387837439 0.0260503894014378 GO:0044389 ubiquitin-like protein ligase binding 72/2948 322/18639 0.22360248447205 1.41374718727087 0.0011819274762294 0.0309664998772103 GO:0005520 insulin-like growth factor binding 9/2948 19/18639 0.473684210526316 2.9949118046133 0.0012405811485224 0.0318659079326342 GO:0031625 ubiquitin protein ligase binding 68/2948 302/18639 0.225165562913907 1.42362989387799 0.00131625824988196 0.0331595828335647 GO:0033218 amide binding 57/2948 247/18639 0.230769230769231 1.4590595971193 0.00171927417284615 0.0414904877527546 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 7/2948 13/18639 0.538461538461538 3.40447239327836 0.00174196704305458 0.0414904877527546 GO:0031994 insulin-like growth factor I binding 7/2948 13/18639 0.538461538461538 3.40447239327836 0.00174196704305458 0.0414904877527546 GO:0019887 protein kinase regulator activity 58/2948 255/18639 0.227450980392157 1.43807965519994 0.00223988152891746 0.0523972286228905 GO:0055106 ubiquitin-protein transferase regulator activity 13/2948 36/18639 0.361111111111111 2.28315807327001 0.00240115286179836 0.0545426932089612 GO:0032977 membrane insertase activity 8/2948 17/18639 0.470588235294118 2.97533721765504 0.00245366416702149 0.0545426932089612 GO:0140296 general transcription initiation factor binding 17/2948 53/18639 0.320754716981132 2.02800107524129 0.0024565029765868 0.0545426932089612 GO:0072341 modified amino acid binding 25/2948 91/18639 0.274725274725275 1.73697571085631 0.00318839193783393 0.0696132239760409 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 6/2948 11/18639 0.545454545454545 3.4486863204638 0.00349859512918024 0.0751337642496084 GO:0019207 kinase regulator activity 63/2948 287/18639 0.219512195121951 1.38788595823543 0.00362172325647679 0.0754866224413042 GO:0004540 RNA nuclease activity 31/2948 121/18639 0.256198347107438 1.61983751415724 0.00363027268229173 0.0754866224413042 GO:0043178 alcohol binding 25/2948 92/18639 0.271739130434783 1.71809554008613 0.00373329008443928 0.0756114915504252 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 8/2948 18/18639 0.444444444444444 2.81004070556309 0.00380943392544127 0.0756114915504252 GO:0070064 proline-rich region binding 8/2948 18/18639 0.444444444444444 2.81004070556309 0.00380943392544127 0.0756114915504252 GO:0140098 catalytic activity, acting on RNA 81/2948 387/18639 0.209302325581395 1.32333312296867 0.00426222257427907 0.0833359936165011 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 13/2948 39/18639 0.333333333333333 2.10753052917232 0.00532054539803908 0.102232368228664 GO:0048306 calcium-dependent protein binding 22/2948 80/18639 0.275 1.73871268656716 0.00538475832654796 0.102232368228664 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 6/2948 12/18639 0.5 3.16129579375848 0.00606633517157705 0.111928155982619 GO:0097371 MDM2/MDM4 family protein binding 6/2948 12/18639 0.5 3.16129579375848 0.00606633517157705 0.111928155982619 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 12/2948 36/18639 0.333333333333333 2.10753052917232 0.00729367975378096 0.129117844289906 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 12/2948 36/18639 0.333333333333333 2.10753052917232 0.00729367975378096 0.129117844289906 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 12/2948 36/18639 0.333333333333333 2.10753052917232 0.00729367975378096 0.129117844289906 GO:0043023 ribosomal large subunit binding 7/2948 16/18639 0.4375 2.76613381953867 0.00750339603919244 0.130262850773529 GO:0015485 cholesterol binding 16/2948 54/18639 0.296296296296296 1.8733604703754 0.00768628942084763 0.130262850773529 GO:0051287 NAD binding 16/2948 54/18639 0.296296296296296 1.8733604703754 0.00768628942084763 0.130262850773529 GO:0032934 sterol binding 19/2948 68/18639 0.279411764705882 1.76660647298268 0.00775610867201168 0.130262850773529 GO:0016829 lyase activity 45/2948 200/18639 0.225 1.42258310719132 0.00795332793498742 0.131884298668779 GO:0004521 RNA endonuclease activity 20/2948 73/18639 0.273972602739726 1.73221687329232 0.00808638871005467 0.132111061844966 GO:0043024 ribosomal small subunit binding 8/2948 20/18639 0.4 2.52903663500678 0.00816869924384904 0.132111061844966 GO:0008374 O-acyltransferase activity 16/2948 55/18639 0.290909090909091 1.83929937091402 0.00928291520926494 0.148300230782159 GO:0030291 protein serine/threonine kinase inhibitor activity 14/2948 46/18639 0.304347826086957 1.92426700489647 0.00953209958076693 0.148866822281641 GO:0046332 SMAD binding 21/2948 79/18639 0.265822784810127 1.68068890301084 0.0097207308127715 0.148866822281641 GO:0019855 calcium channel inhibitor activity 6/2948 13/18639 0.461538461538462 2.9181191942386 0.0097729364245963 0.148866822281641 GO:0039706 co-receptor binding 6/2948 13/18639 0.461538461538462 2.9181191942386 0.0097729364245963 0.148866822281641 GO:0140311 protein sequestering activity 11/2948 33/18639 0.333333333333333 2.10753052917232 0.0100251258890901 0.150953044996645 GO:0016859 cis-trans isomerase activity 13/2948 42/18639 0.30952380952381 1.95699263423144 0.0105605417108198 0.154523671885871 GO:0051879 Hsp90 protein binding 13/2948 42/18639 0.30952380952381 1.95699263423144 0.0105605417108198 0.154523671885871 GO:0004549 tRNA-specific ribonuclease activity 7/2948 17/18639 0.411764705882353 2.60342006544816 0.0110382083497121 0.154523671885871 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 7/2948 17/18639 0.411764705882353 2.60342006544816 0.0110382083497121 0.154523671885871 GO:0051787 misfolded protein binding 7/2948 17/18639 0.411764705882353 2.60342006544816 0.0110382083497121 0.154523671885871 GO:0070402 NADPH binding 7/2948 17/18639 0.411764705882353 2.60342006544816 0.0110382083497121 0.154523671885871 GO:0017025 TBP-class protein binding 9/2948 25/18639 0.36 2.27613297150611 0.0112059151367617 0.154523671885871 GO:0019211 phosphatase activator activity 9/2948 25/18639 0.36 2.27613297150611 0.0112059151367617 0.154523671885871 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 8/2948 21/18639 0.380952380952381 2.40860631905408 0.0113958845627483 0.155506341429169 GO:0002020 protease binding 32/2948 136/18639 0.235294117647059 1.48766860882752 0.0119726567303311 0.161692580584883 GO:0003680 minor groove of adenine-thymine-rich DNA binding 5/2948 10/18639 0.5 3.16129579375848 0.0123637348770753 0.164720730332383 GO:0003779 actin binding 88/2948 443/18639 0.198645598194131 1.25595498803949 0.0124483605365694 0.164720730332383 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 11/2948 34/18639 0.323529411764706 2.04554433713784 0.0127464948560114 0.166193976349509 GO:0098631 cell adhesion mediator activity 20/2948 76/18639 0.263157894736842 1.66383989145183 0.0128134287109164 0.166193976349509 GO:0001968 fibronectin binding 10/2948 30/18639 0.333333333333333 2.10753052917232 0.0138228456846798 0.177528704381673 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 14/2948 48/18639 0.291666666666667 1.84408921302578 0.0141035354914397 0.178409828005187 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/2948 39/18639 0.307692307692308 1.94541279615907 0.0144511907478239 0.178409828005187 GO:0005525 GTP binding 76/2948 378/18639 0.201058201058201 1.27120889061188 0.0145282766375717 0.178409828005187 GO:0032036 myosin heavy chain binding 6/2948 14/18639 0.428571428571429 2.70968210893584 0.0148447872156988 0.178409828005187 GO:0034236 protein kinase A catalytic subunit binding 6/2948 14/18639 0.428571428571429 2.70968210893584 0.0148447872156988 0.178409828005187 GO:0042043 neurexin family protein binding 6/2948 14/18639 0.428571428571429 2.70968210893584 0.0148447872156988 0.178409828005187 GO:0044548 S100 protein binding 6/2948 14/18639 0.428571428571429 2.70968210893584 0.0148447872156988 0.178409828005187 GO:0000900 mRNA regulatory element binding translation repressor activity 7/2948 18/18639 0.388888888888889 2.45878561736771 0.0156383375287935 0.1845605600245 GO:0035615 clathrin adaptor activity 7/2948 18/18639 0.388888888888889 2.45878561736771 0.0156383375287935 0.1845605600245 GO:0001222 transcription corepressor binding 14/2948 49/18639 0.285714285714286 1.80645473929056 0.0169438245165805 0.198182233185004 GO:0016878 acid-thiol ligase activity 10/2948 31/18639 0.32258064516129 2.03954567339257 0.0175793105914261 0.202803190279421 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 15/2948 54/18639 0.277777777777778 1.75627544097693 0.0178033334978117 0.202803190279421 GO:0050661 NADP binding 15/2948 54/18639 0.277777777777778 1.75627544097693 0.0178033334978117 0.202803190279421 GO:0016835 carbon-oxygen lyase activity 20/2948 79/18639 0.253164556962025 1.60065609810556 0.0195034750717698 0.216378675616318 GO:0002162 dystroglycan binding 5/2948 11/18639 0.454545454545455 2.87390526705316 0.0197513513336545 0.216378675616318 GO:0003953 NAD+ nucleosidase activity 5/2948 11/18639 0.454545454545455 2.87390526705316 0.0197513513336545 0.216378675616318 GO:0097493 structural molecule activity conferring elasticity 5/2948 11/18639 0.454545454545455 2.87390526705316 0.0197513513336545 0.216378675616318 GO:0004869 cysteine-type endopeptidase inhibitor activity 11/2948 36/18639 0.305555555555556 1.93190298507463 0.0198209473847009 0.216378675616318 GO:0001221 transcription coregulator binding 27/2948 115/18639 0.234782608695652 1.48443454663442 0.0202984389641768 0.21975995903365 GO:0140313 molecular sequestering activity 15/2948 55/18639 0.272727272727273 1.7243431602319 0.0209984903560168 0.223833679762983 GO:0031072 heat shock protein binding 30/2948 131/18639 0.229007633587786 1.4479217375993 0.0210164447411045 0.223833679762983 GO:0016918 retinal binding 7/2948 19/18639 0.368421052631579 2.32937584803256 0.0214487149678138 0.226595295224484 GO:0030515 snoRNA binding 10/2948 32/18639 0.3125 1.97580987109905 0.022036772576863 0.230945376605524 GO:0019003 GDP binding 19/2948 75/18639 0.253333333333333 1.60172320217096 0.0222684397881901 0.231521080337532 GO:0051019 mitogen-activated protein kinase binding 9/2948 28/18639 0.321428571428571 2.03226158170188 0.0243361951733701 0.251026895095392 GO:0001618 virus receptor activity 20/2948 81/18639 0.246913580246914 1.56113372531283 0.0252836225966612 0.258762075012705 GO:0051015 actin filament binding 44/2948 209/18639 0.210526315789474 1.33107191316147 0.0263759015875924 0.267848302943768 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/2948 24/18639 0.333333333333333 2.10753052917232 0.0266009253479194 0.268055478505957 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 10/2948 33/18639 0.303030303030303 1.91593684470211 0.0272592276585032 0.269125006592991 GO:0030295 protein kinase activator activity 31/2948 139/18639 0.223021582733813 1.41007438282752 0.0272680804631993 0.269125006592991 GO:0061134 peptidase regulator activity 47/2948 226/18639 0.207964601769911 1.31487524165176 0.0273233785319601 0.269125006592991 GO:0052689 carboxylic ester hydrolase activity 22/2948 92/18639 0.239130434782609 1.5119240752758 0.0278289280163404 0.27205892314482 GO:0140272 exogenous protein binding 20/2948 82/18639 0.24390243902439 1.54209550915048 0.0286216469466183 0.277598533963981 GO:0005501 retinoid binding 11/2948 38/18639 0.289473684210526 1.83022388059702 0.0294348138859323 0.277598533963981 GO:0019840 isoprenoid binding 11/2948 38/18639 0.289473684210526 1.83022388059702 0.0294348138859323 0.277598533963981 GO:0004300 enoyl-CoA hydratase activity 5/2948 12/18639 0.416666666666667 2.6344131614654 0.0295263628779956 0.277598533963981 GO:0004526 ribonuclease P activity 5/2948 12/18639 0.416666666666667 2.6344131614654 0.0295263628779956 0.277598533963981 GO:0008142 oxysterol binding 6/2948 16/18639 0.375 2.37097184531886 0.0298789261747491 0.277598533963981 GO:0019841 retinol binding 6/2948 16/18639 0.375 2.37097184531886 0.0298789261747491 0.277598533963981 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 12/2948 43/18639 0.27906976744186 1.76444416395822 0.0310066962788634 0.284047357519658 GO:0048156 tau protein binding 12/2948 43/18639 0.27906976744186 1.76444416395822 0.0310066962788634 0.284047357519658 GO:0001540 amyloid-beta binding 20/2948 83/18639 0.240963855421687 1.52351604518481 0.0322808476165143 0.291640761225061 GO:0030165 PDZ domain binding 20/2948 83/18639 0.240963855421687 1.52351604518481 0.0322808476165143 0.291640761225061 GO:0004864 protein phosphatase inhibitor activity 14/2948 53/18639 0.264150943396226 1.67011853255165 0.0327953782880717 0.294259901077904 GO:0017124 SH3 domain binding 26/2948 115/18639 0.226086956521739 1.42945548935166 0.0347957133956544 0.305922043948371 GO:0035401 histone H3Y41 kinase activity 26/2948 115/18639 0.226086956521739 1.42945548935166 0.0347957133956544 0.305922043948371 GO:0140801 histone H2AXY142 kinase activity 26/2948 115/18639 0.226086956521739 1.42945548935166 0.0347957133956544 0.305922043948371 GO:0019001 guanyl nucleotide binding 77/2948 400/18639 0.1925 1.21709888059701 0.0358317892271566 0.310858568791889 GO:0032561 guanyl ribonucleotide binding 77/2948 400/18639 0.1925 1.21709888059701 0.0358317892271566 0.310858568791889 GO:0043014 alpha-tubulin binding 12/2948 44/18639 0.272727272727273 1.7243431602319 0.0366947047827211 0.311811717111134 GO:0072542 protein phosphatase activator activity 7/2948 21/18639 0.333333333333333 2.10753052917232 0.0372012967166257 0.311811717111134 GO:0140312 cargo adaptor activity 7/2948 21/18639 0.333333333333333 2.10753052917232 0.0372012967166257 0.311811717111134 GO:0019209 kinase activator activity 32/2948 148/18639 0.216216216216216 1.3670468297334 0.0375422554178158 0.311811717111134 GO:0060590 ATPase regulator activity 13/2948 49/18639 0.26530612244898 1.67742225791266 0.0375657314246118 0.311811717111134 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/2948 30/18639 0.3 1.89677747625509 0.0376078254225643 0.311811717111134 GO:0070566 adenylyltransferase activity 9/2948 30/18639 0.3 1.89677747625509 0.0376078254225643 0.311811717111134 GO:0017171 serine hydrolase activity 41/2948 198/18639 0.207070707070707 1.30922351054644 0.0395297313866246 0.324948606254197 GO:0031406 carboxylic acid binding 39/2948 187/18639 0.20855614973262 1.31861535782439 0.0396883793898256 0.324948606254197 GO:0015631 tubulin binding 74/2948 385/18639 0.192207792207792 1.2152513700682 0.0401159871260174 0.326409584689955 GO:0000049 tRNA binding 19/2948 80/18639 0.2375 1.50161550203528 0.0414721732964041 0.328030741877675 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 5/2948 13/18639 0.384615384615385 2.43176599519883 0.0418722544113702 0.328030741877675 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 5/2948 13/18639 0.384615384615385 2.43176599519883 0.0418722544113702 0.328030741877675 GO:0015036 disulfide oxidoreductase activity 11/2948 40/18639 0.275 1.73871268656716 0.0419874644103035 0.328030741877675 GO:0019208 phosphatase regulator activity 26/2948 117/18639 0.222222222222222 1.40502035278155 0.0421103971779745 0.328030741877675 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 8/2948 26/18639 0.307692307692308 1.94541279615907 0.0423184697536847 0.328030741877675 GO:0030247 polysaccharide binding 8/2948 26/18639 0.307692307692308 1.94541279615907 0.0423184697536847 0.328030741877675 GO:0043548 phosphatidylinositol 3-kinase binding 8/2948 26/18639 0.307692307692308 1.94541279615907 0.0423184697536847 0.328030741877675 GO:0042605 peptide antigen binding 12/2948 45/18639 0.266666666666667 1.68602442333786 0.0430812621126058 0.330229405946819 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 28/2948 128/18639 0.21875 1.38306690976934 0.043136404143339 0.330229405946819 GO:0005200 structural constituent of cytoskeleton 25/2948 112/18639 0.223214285714286 1.41129276507075 0.0434752702944228 0.330229405946819 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 15/2948 60/18639 0.25 1.58064789687924 0.0437558996819768 0.330229405946819 GO:0098632 cell-cell adhesion mediator activity 14/2948 55/18639 0.254545454545455 1.60938694954977 0.0438625317822492 0.330229405946819 GO:0004866 endopeptidase inhibitor activity 34/2948 161/18639 0.211180124223602 1.33520567686694 0.0444687858832924 0.332880625754931 GO:0016209 antioxidant activity 20/2948 86/18639 0.232558139534884 1.47037013663185 0.0453456341317555 0.337515799503407 GO:0043177 organic acid binding 39/2948 189/18639 0.206349206349206 1.30466175615429 0.0458457057961055 0.339310025948577 GO:0004713 protein tyrosine kinase activity 30/2948 140/18639 0.214285714285714 1.35484105446792 0.0476404114094455 0.350612016552661 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 46/2948 229/18639 0.200873362445415 1.27004023155363 0.0486328320986772 0.355916257258476 GO:0019902 phosphatase binding 39/2948 190/18639 0.205263157894737 1.29779511533243 0.0491795612354039 0.357917917879884 GO:0016836 hydro-lyase activity 15/2948 61/18639 0.245901639344262 1.55473563627466 0.0498481262940959 0.360779256603677 GO:0019212 phosphatase inhibitor activity 14/2948 56/18639 0.25 1.58064789687924 0.0502806378290373 0.361910085472741 GO:0000287 magnesium ion binding 46/2948 230/18639 0.2 1.26451831750339 0.0517813131753627 0.370352233239033 GO:0015252 proton channel activity 8/2948 27/18639 0.296296296296296 1.8733604703754 0.052081489924882 0.370352233239033 GO:1990381 ubiquitin-specific protease binding 6/2948 18/18639 0.333333333333333 2.10753052917232 0.0524143532636663 0.370352233239033 GO:0051540 metal cluster binding 18/2948 77/18639 0.233766233766234 1.47800842305591 0.0531175694213968 0.370352233239033 GO:0016853 isomerase activity 37/2948 180/18639 0.205555555555556 1.29964382632293 0.0532068279855013 0.370352233239033 GO:0030414 peptidase inhibitor activity 35/2948 169/18639 0.207100591715976 1.30941245895322 0.053595952617757 0.370352233239033 GO:0005161 platelet-derived growth factor receptor binding 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:0008191 metalloendopeptidase inhibitor activity 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:0016530 metallochaperone activity 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:0031404 chloride ion binding 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:0061665 SUMO ligase activity 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:1990825 sequence-specific mRNA binding 5/2948 14/18639 0.357142857142857 2.2580684241132 0.0568875139645208 0.370352233239033 GO:0043394 proteoglycan binding 10/2948 37/18639 0.27027027027027 1.70880853716675 0.0568954397494942 0.370352233239033 GO:0141108 transporter regulator activity 35/2948 170/18639 0.205882352941176 1.30171003272408 0.0575904006031792 0.370352233239033 GO:0008135 translation factor activity, RNA binding 19/2948 83/18639 0.228915662650602 1.44734024292557 0.0576011201590746 0.370352233239033 GO:0031492 nucleosomal DNA binding 11/2948 42/18639 0.261904761904762 1.65591684434968 0.0578080882736023 0.370352233239033 GO:0005080 protein kinase C binding 13/2948 52/18639 0.25 1.58064789687924 0.0578732608543975 0.370352233239033 GO:0043274 phospholipase binding 7/2948 23/18639 0.304347826086957 1.92426700489647 0.0590817272385123 0.370352233239033 GO:0001094 TFIID-class transcription factor complex binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0030957 Tat protein binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0033204 ribonuclease P RNA binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0047429 nucleoside triphosphate diphosphatase activity 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0050815 phosphoserine residue binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0070097 delta-catenin binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0070739 protein-glutamic acid ligase activity 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0070740 tubulin-glutamic acid ligase activity 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0097177 mitochondrial ribosome binding 4/2948 10/18639 0.4 2.52903663500678 0.0591109858857758 0.370352233239033 GO:0004252 serine-type endopeptidase activity 36/2948 176/18639 0.204545454545455 1.29325737017392 0.059369441969616 0.370352233239033 GO:0004519 endonuclease activity 27/2948 127/18639 0.21259842519685 1.34417301466896 0.0628019280644674 0.389907705044797 GO:0097718 disordered domain specific binding 8/2948 28/18639 0.285714285714286 1.80645473929056 0.0631796078254869 0.390402293638622 GO:0005507 copper ion binding 15/2948 63/18639 0.238095238095238 1.5053789494088 0.0637495661843126 0.390760509143423 GO:0180051 translation factor activity 19/2948 84/18639 0.226190476190476 1.43011000193836 0.0638341595089256 0.390760509143423 GO:0008236 serine-type peptidase activity 39/2948 194/18639 0.201030927835052 1.27103645316063 0.06432227858786 0.391917139302775 GO:0019955 cytokine binding 30/2948 144/18639 0.208333333333333 1.3172065807327 0.0652998568643778 0.395661913270218 GO:0030296 protein tyrosine kinase activator activity 9/2948 33/18639 0.272727272727273 1.7243431602319 0.0655409428852193 0.395661913270218 GO:0070003 threonine-type peptidase activity 6/2948 19/18639 0.315789473684211 1.9966078697422 0.0667061863232904 0.399018740107354 GO:0120227 acyl-CoA binding 6/2948 19/18639 0.315789473684211 1.9966078697422 0.0667061863232904 0.399018740107354 GO:0008200 ion channel inhibitor activity 11/2948 43/18639 0.255813953488372 1.61740715029504 0.0670210667717939 0.399079988504772 GO:0019842 vitamin binding 31/2948 150/18639 0.206666666666667 1.30666892808684 0.0675745486729065 0.400555017020396 GO:0005516 calmodulin binding 41/2948 207/18639 0.198067632850242 1.25230074921834 0.0715928743762198 0.422462456904721 GO:0019888 protein phosphatase regulator activity 23/2948 107/18639 0.214953271028037 1.35906174311112 0.0732200449382849 0.424822860371169 GO:0004879 nuclear receptor activity 14/2948 59/18639 0.23728813559322 1.50027596991928 0.073332268680056 0.424822860371169 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 14/2948 59/18639 0.23728813559322 1.50027596991928 0.073332268680056 0.424822860371169 GO:0016247 channel regulator activity 34/2948 168/18639 0.202380952380952 1.27957210699748 0.0738206104200232 0.424822860371169 GO:0004467 long-chain fatty acid-CoA ligase activity 5/2948 15/18639 0.333333333333333 2.10753052917232 0.0745872197598236 0.424822860371169 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/2948 15/18639 0.333333333333333 2.10753052917232 0.0745872197598236 0.424822860371169 GO:0048531 beta-1,3-galactosyltransferase activity 5/2948 15/18639 0.333333333333333 2.10753052917232 0.0745872197598236 0.424822860371169 GO:0140776 protein-containing complex destabilizing activity 5/2948 15/18639 0.333333333333333 2.10753052917232 0.0745872197598236 0.424822860371169 GO:0003785 actin monomer binding 8/2948 29/18639 0.275862068965517 1.7441631965564 0.0756395226156918 0.428951405309767 GO:0016248 channel inhibitor activity 11/2948 44/18639 0.25 1.58064789687924 0.0771298541014847 0.431882649935329 GO:0030020 extracellular matrix structural constituent conferring tensile strength 11/2948 44/18639 0.25 1.58064789687924 0.0771298541014847 0.431882649935329 GO:0015035 protein-disulfide reductase activity 9/2948 34/18639 0.264705882352941 1.67362718493096 0.0771454504464634 0.431882649935329 GO:0097110 scaffold protein binding 16/2948 70/18639 0.228571428571429 1.44516379143245 0.0776843403006227 0.433048875718365 GO:0005496 steroid binding 23/2948 108/18639 0.212962962962963 1.34647783808232 0.0796830187892132 0.434548330793077 GO:0004518 nuclease activity 41/2948 209/18639 0.196172248803828 1.24031700999137 0.0806939804483578 0.434548330793077 GO:0008432 JUN kinase binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0019107 myristoyltransferase activity 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0019215 intermediate filament binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0032794 GTPase activating protein binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0042608 T cell receptor binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0048407 platelet-derived growth factor binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0050998 nitric-oxide synthase binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0070990 snRNP binding 4/2948 11/18639 0.363636363636364 2.29912421364253 0.081602205629845 0.434548330793077 GO:0098531 ligand-modulated transcription factor activity 14/2948 60/18639 0.233333333333333 1.47527137042062 0.082333772288167 0.436560495603874 GO:0001972 retinoic acid binding 6/2948 20/18639 0.3 1.89677747625509 0.0830376264624151 0.436560495603874 GO:0017022 myosin binding 17/2948 76/18639 0.223684210526316 1.41426390773406 0.0833130716801286 0.436560495603874 GO:0051536 iron-sulfur cluster binding 17/2948 76/18639 0.223684210526316 1.41426390773406 0.0833130716801286 0.436560495603874 GO:0003714 transcription corepressor activity 40/2948 204/18639 0.196078431372549 1.2397238406896 0.0840728124361109 0.438786391598826 GO:0015645 fatty acid ligase activity 7/2948 25/18639 0.28 1.77032564450475 0.0874713847025957 0.452826287455579 GO:0120515 fatty acid-CoA ligase activity 7/2948 25/18639 0.28 1.77032564450475 0.0874713847025957 0.452826287455579 GO:0004715 non-membrane spanning protein tyrosine kinase activity 11/2948 45/18639 0.244444444444444 1.5455223880597 0.0881455750390632 0.452826287455579 GO:0141110 transporter inhibitor activity 11/2948 45/18639 0.244444444444444 1.5455223880597 0.0881455750390632 0.452826287455579 GO:0016769 transferase activity, transferring nitrogenous groups 8/2948 30/18639 0.266666666666667 1.68602442333786 0.0894692306859199 0.457830828900606 GO:0099106 ion channel regulator activity 32/2948 160/18639 0.2 1.26451831750339 0.0916067513655562 0.466944919411979 GO:0000062 fatty-acyl-CoA binding 5/2948 16/18639 0.3125 1.97580987109905 0.0949091713894029 0.476364040306965 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/2948 16/18639 0.3125 1.97580987109905 0.0949091713894029 0.476364040306965 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 5/2948 16/18639 0.3125 1.97580987109905 0.0949091713894029 0.476364040306965 GO:0070411 I-SMAD binding 5/2948 16/18639 0.3125 1.97580987109905 0.0949091713894029 0.476364040306965 GO:0008017 microtubule binding 52/2948 276/18639 0.188405797101449 1.19121290779305 0.0980321622038351 0.490160811019175 GO:0061135 endopeptidase regulator activity 36/2948 184/18639 0.195652173913043 1.23702878886201 0.0992590849356051 0.494408369831341 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6/2948 21/18639 0.285714285714286 1.80645473929056 0.101372158360731 0.496509036540699 GO:0070182 DNA polymerase binding 6/2948 21/18639 0.285714285714286 1.80645473929056 0.101372158360731 0.496509036540699 GO:0016877 ligase activity, forming carbon-sulfur bonds 10/2948 41/18639 0.24390243902439 1.54209550915048 0.102239677273146 0.496509036540699 GO:0003712 transcription coregulator activity 89/2948 495/18639 0.17979797979798 1.13678919452325 0.102580185898736 0.496509036540699 GO:0045505 dynein intermediate chain binding 9/2948 36/18639 0.25 1.58064789687924 0.103870653079453 0.496509036540699 GO:0004601 peroxidase activity 13/2948 57/18639 0.228070175438596 1.44199457259159 0.105934397732497 0.496509036540699 GO:0016504 peptidase activator activity 13/2948 57/18639 0.228070175438596 1.44199457259159 0.105934397732497 0.496509036540699 GO:0004859 phospholipase inhibitor activity 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0005025 transforming growth factor beta receptor activity, type I 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0005026 transforming growth factor beta receptor activity, type II 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0005049 nuclear export signal receptor activity 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0005165 neurotrophin receptor binding 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0016361 activin receptor activity, type I 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0016362 activin receptor activity, type II 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0016801 hydrolase activity, acting on ether bonds 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0016803 ether hydrolase activity 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0017002 activin receptor activity 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0035259 nuclear glucocorticoid receptor binding 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0035497 cAMP response element binding 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0045295 gamma-catenin binding 4/2948 12/18639 0.333333333333333 2.10753052917232 0.10764012700577 0.496509036540699 GO:0033293 monocarboxylic acid binding 17/2948 79/18639 0.215189873417722 1.36055768338973 0.110596998949588 0.508358135522667 GO:0005504 fatty acid binding 11/2948 47/18639 0.234042553191489 1.4797554779295 0.112903098657345 0.517143563780145 GO:0031491 nucleosome binding 16/2948 74/18639 0.216216216216216 1.3670468297334 0.115241725738016 0.52601623943136 GO:0005092 GDP-dissociation inhibitor activity 5/2948 17/18639 0.294117647058824 1.8595857610344 0.117723125571637 0.528822710476586 GO:1901567 fatty acid derivative binding 5/2948 17/18639 0.294117647058824 1.8595857610344 0.117723125571637 0.528822710476586 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 26/2948 130/18639 0.2 1.26451831750339 0.118556098586669 0.528822710476586 GO:0002039 p53 binding 15/2948 69/18639 0.217391304347826 1.3744764320689 0.12007793716154 0.528822710476586 GO:0031369 translation initiation factor binding 8/2948 32/18639 0.25 1.58064789687924 0.121177272426681 0.528822710476586 GO:0051059 NF-kappaB binding 8/2948 32/18639 0.25 1.58064789687924 0.121177272426681 0.528822710476586 GO:0044325 transmembrane transporter binding 27/2948 136/18639 0.198529411764706 1.25522038869822 0.121234702121082 0.528822710476586 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 6/2948 22/18639 0.272727272727273 1.7243431602319 0.121633647788965 0.528822710476586 GO:0016881 acid-amino acid ligase activity 6/2948 22/18639 0.272727272727273 1.7243431602319 0.121633647788965 0.528822710476586 GO:0070034 telomerase RNA binding 6/2948 22/18639 0.272727272727273 1.7243431602319 0.121633647788965 0.528822710476586 GO:0140297 DNA-binding transcription factor binding 87/2948 488/18639 0.17827868852459 1.12718333629913 0.121656841057141 0.528822710476586 GO:0005246 calcium channel regulator activity 12/2948 53/18639 0.226415094339623 1.43153017075856 0.122186828796688 0.528822710476586 GO:0016860 intramolecular oxidoreductase activity 12/2948 53/18639 0.226415094339623 1.43153017075856 0.122186828796688 0.528822710476586 GO:0051018 protein kinase A binding 12/2948 53/18639 0.226415094339623 1.43153017075856 0.122186828796688 0.528822710476586 GO:0001671 ATPase activator activity 7/2948 27/18639 0.259259259259259 1.63919041157847 0.122315481888859 0.528822710476586 GO:0016405 CoA-ligase activity 7/2948 27/18639 0.259259259259259 1.63919041157847 0.122315481888859 0.528822710476586 GO:1901681 sulfur compound binding 51/2948 275/18639 0.185454545454545 1.17255334895769 0.12288201458719 0.529524470754008 GO:0008375 acetylglucosaminyltransferase activity 10/2948 43/18639 0.232558139534884 1.47037013663185 0.131004391885113 0.562674601211469 GO:0043531 ADP binding 9/2948 38/18639 0.236842105263158 1.49745590230665 0.135190628929547 0.572843716646319 GO:0005542 folic acid binding 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0017154 semaphorin receptor activity 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0019104 DNA N-glycosylase activity 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0035325 Toll-like receptor binding 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0070123 transforming growth factor beta receptor activity, type III 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0097157 pre-mRNA intronic binding 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0140852 histone ubiquitin ligase activity 4/2948 13/18639 0.307692307692308 1.94541279615907 0.136870292603281 0.572843716646319 GO:0019903 protein phosphatase binding 28/2948 144/18639 0.194444444444444 1.22939280868385 0.140041189717006 0.58424827557095 GO:0019789 SUMO transferase activity 7/2948 28/18639 0.25 1.58064789687924 0.142027439909983 0.584807133390138 GO:0051537 2 iron, 2 sulfur cluster binding 7/2948 28/18639 0.25 1.58064789687924 0.142027439909983 0.584807133390138 GO:0017128 phospholipid scramblase activity 5/2948 18/18639 0.277777777777778 1.75627544097693 0.142841884151625 0.584807133390138 GO:0032393 MHC class I receptor activity 5/2948 18/18639 0.277777777777778 1.75627544097693 0.142841884151625 0.584807133390138 GO:1901611 phosphatidylglycerol binding 5/2948 18/18639 0.277777777777778 1.75627544097693 0.142841884151625 0.584807133390138 GO:0042277 peptide binding 46/2948 249/18639 0.184738955823293 1.16802896797502 0.142853650904461 0.584807133390138 GO:0004602 glutathione peroxidase activity 6/2948 23/18639 0.260869565217391 1.64937171848269 0.143710796218537 0.586483311670665 GO:0140375 immune receptor activity 30/2948 156/18639 0.192307692307692 1.21588299759942 0.144237546683788 0.586804925949574 GO:0004197 cysteine-type endopeptidase activity 18/2948 88/18639 0.204545454545455 1.29325737017392 0.147427871133099 0.597927279208546 GO:0031490 chromatin DNA binding 25/2948 128/18639 0.1953125 1.23488116943691 0.15064340914548 0.609082919693146 GO:0000217 DNA secondary structure binding 9/2948 39/18639 0.230769230769231 1.4590595971193 0.152490606576396 0.612769001886747 GO:0016776 phosphotransferase activity, phosphate group as acceptor 9/2948 39/18639 0.230769230769231 1.4590595971193 0.152490606576396 0.612769001886747 GO:0005006 epidermal growth factor receptor activity 11/2948 50/18639 0.22 1.39097014925373 0.156668494322627 0.627632194381168 GO:0016831 carboxy-lyase activity 8/2948 34/18639 0.235294117647059 1.48766860882752 0.158007189397945 0.629147167511574 GO:0030332 cyclin binding 8/2948 34/18639 0.235294117647059 1.48766860882752 0.158007189397945 0.629147167511574 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 18/2948 89/18639 0.202247191011236 1.27872638848658 0.158977538299615 0.629186027711466 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 18/2948 89/18639 0.202247191011236 1.27872638848658 0.158977538299615 0.629186027711466 GO:0019199 transmembrane receptor protein kinase activity 16/2948 78/18639 0.205128205128205 1.29694186410604 0.161952924364382 0.639031117220905 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 14/2948 67/18639 0.208955223880597 1.32113854067519 0.164145754450225 0.645738553542926 GO:0051117 ATPase binding 17/2948 84/18639 0.202380952380952 1.27957210699748 0.166733754855598 0.649040416997845 GO:0035035 histone acetyltransferase binding 6/2948 24/18639 0.25 1.58064789687924 0.167462336599444 0.649040416997845 GO:0050431 transforming growth factor beta binding 6/2948 24/18639 0.25 1.58064789687924 0.167462336599444 0.649040416997845 GO:0070300 phosphatidic acid binding 6/2948 24/18639 0.25 1.58064789687924 0.167462336599444 0.649040416997845 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 6/2948 24/18639 0.25 1.58064789687924 0.167462336599444 0.649040416997845 GO:0098821 BMP receptor activity 4/2948 14/18639 0.285714285714286 1.80645473929056 0.168863404058785 0.649078190348965 GO:1901612 cardiolipin binding 4/2948 14/18639 0.285714285714286 1.80645473929056 0.168863404058785 0.649078190348965 GO:0043539 protein serine/threonine kinase activator activity 15/2948 73/18639 0.205479452054795 1.29916265496924 0.169915707151505 0.649078190348965 GO:0015245 fatty acid transmembrane transporter activity 5/2948 19/18639 0.263157894736842 1.66383989145183 0.170033204804602 0.649078190348965 GO:0043395 heparan sulfate proteoglycan binding 5/2948 19/18639 0.263157894736842 1.66383989145183 0.170033204804602 0.649078190348965 GO:0140793 histone H2AXY142 phosphatase activity 18/2948 90/18639 0.2 1.26451831750339 0.170999188720059 0.649078190348965 GO:0003743 translation initiation factor activity 11/2948 51/18639 0.215686274509804 1.36369622475856 0.172922357581518 0.649078190348965 GO:0005021 vascular endothelial growth factor receptor activity 11/2948 51/18639 0.215686274509804 1.36369622475856 0.172922357581518 0.649078190348965 GO:0005030 neurotrophin receptor activity 11/2948 51/18639 0.215686274509804 1.36369622475856 0.172922357581518 0.649078190348965 GO:0016597 amino acid binding 11/2948 51/18639 0.215686274509804 1.36369622475856 0.172922357581518 0.649078190348965 GO:0030544 Hsp70 protein binding 11/2948 51/18639 0.215686274509804 1.36369622475856 0.172922357581518 0.649078190348965 GO:0005539 glycosaminoglycan binding 44/2948 242/18639 0.181818181818182 1.14956210682127 0.176287629578241 0.659819413564275 GO:0005154 epidermal growth factor receptor binding 8/2948 35/18639 0.228571428571429 1.44516379143245 0.178180167839423 0.662081569019948 GO:0016229 steroid dehydrogenase activity 8/2948 35/18639 0.228571428571429 1.44516379143245 0.178180167839423 0.662081569019948 GO:0005548 phospholipid transporter activity 14/2948 68/18639 0.205882352941176 1.30171003272408 0.178408239590871 0.662081569019948 GO:0003684 damaged DNA binding 15/2948 74/18639 0.202702702702703 1.28160640287506 0.183815871917646 0.680222576870386 GO:0031624 ubiquitin conjugating enzyme binding 7/2948 30/18639 0.233333333333333 1.47527137042062 0.185575714321657 0.684800523271466 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/2948 41/18639 0.219512195121951 1.38788595823543 0.190103182314564 0.691222870888701 GO:0017080 sodium channel regulator activity 9/2948 41/18639 0.219512195121951 1.38788595823543 0.190103182314564 0.691222870888701 GO:0001848 complement binding 6/2948 25/18639 0.24 1.51742198100407 0.192722637198449 0.691222870888701 GO:0008483 transaminase activity 6/2948 25/18639 0.24 1.51742198100407 0.192722637198449 0.691222870888701 GO:0016505 peptidase activator activity involved in apoptotic process 5/2948 20/18639 0.25 1.58064789687924 0.199031730918664 0.691222870888701 GO:0044390 ubiquitin-like protein conjugating enzyme binding 8/2948 36/18639 0.222222222222222 1.40502035278155 0.199411457770842 0.691222870888701 GO:0004725 protein tyrosine phosphatase activity 19/2948 98/18639 0.193877551020408 1.22580857309002 0.19966617823929 0.691222870888701 GO:0042826 histone deacetylase binding 24/2948 127/18639 0.188976377952756 1.19482045748352 0.199982625327252 0.691222870888701 GO:0000182 rDNA binding 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0005031 tumor necrosis factor receptor activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0005381 iron ion transmembrane transporter activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0005522 profilin binding 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0015643 toxic substance binding 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0016868 intramolecular phosphotransferase activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0019911 structural constituent of myelin sheath 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0031419 cobalamin binding 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0032395 MHC class II receptor activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:1990757 ubiquitin ligase activator activity 3/2948 10/18639 0.3 1.89677747625509 0.201382270304203 0.691222870888701 GO:0000774 adenyl-nucleotide exchange factor activity 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0005523 tropomyosin binding 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0008242 omega peptidase activity 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0015929 hexosaminidase activity 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0045504 dynein heavy chain binding 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0050700 CARD domain binding 4/2948 15/18639 0.266666666666667 1.68602442333786 0.203145652894771 0.691222870888701 GO:0061659 ubiquitin-like protein ligase activity 65/2948 372/18639 0.174731182795699 1.10475390642097 0.206600007351271 0.701155465363122 GO:0005544 calcium-dependent phospholipid binding 11/2948 53/18639 0.207547169811321 1.31223598986201 0.207692442697546 0.701229639004602 GO:0038064 collagen receptor activity 11/2948 53/18639 0.207547169811321 1.31223598986201 0.207692442697546 0.701229639004602 GO:0017147 Wnt-protein binding 7/2948 31/18639 0.225806451612903 1.4276819713748 0.209176693013045 0.702718665752683 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 23/2948 122/18639 0.188524590163934 1.19196398781057 0.209523462505491 0.702718665752683 GO:0008307 structural constituent of muscle 9/2948 42/18639 0.214285714285714 1.35484105446792 0.210279173263398 0.702718665752683 GO:0019894 kinesin binding 9/2948 42/18639 0.214285714285714 1.35484105446792 0.210279173263398 0.702718665752683 GO:0015459 potassium channel regulator activity 12/2948 59/18639 0.203389830508475 1.28595083135938 0.214304317728703 0.714347725762342 GO:0005112 Notch binding 6/2948 26/18639 0.230769230769231 1.4590595971193 0.219307427610746 0.723927136139946 GO:0005227 calcium-activated cation channel activity 6/2948 26/18639 0.230769230769231 1.4590595971193 0.219307427610746 0.723927136139946 GO:0034237 protein kinase A regulatory subunit binding 6/2948 26/18639 0.230769230769231 1.4590595971193 0.219307427610746 0.723927136139946 GO:0120013 lipid transfer activity 13/2948 65/18639 0.2 1.26451831750339 0.219868025180898 0.723927136139946 GO:0022829 wide pore channel activity 8/2948 37/18639 0.216216216216216 1.3670468297334 0.221602251971722 0.723927136139946 GO:0140463 chromatin-protein adaptor activity 11/2948 54/18639 0.203703703703704 1.28793532338308 0.226109469355871 0.723927136139946 GO:0005123 death receptor binding 5/2948 21/18639 0.238095238095238 1.5053789494088 0.229550347343018 0.723927136139946 GO:0009975 cyclase activity 5/2948 21/18639 0.238095238095238 1.5053789494088 0.229550347343018 0.723927136139946 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/2948 21/18639 0.238095238095238 1.5053789494088 0.229550347343018 0.723927136139946 GO:0001098 basal transcription machinery binding 12/2948 60/18639 0.2 1.26451831750339 0.231983402606481 0.723927136139946 GO:0001099 basal RNA polymerase II transcription machinery binding 12/2948 60/18639 0.2 1.26451831750339 0.231983402606481 0.723927136139946 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/2948 60/18639 0.2 1.26451831750339 0.231983402606481 0.723927136139946 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 16/2948 83/18639 0.192771084337349 1.21881283614785 0.232079186096771 0.723927136139946 GO:0008378 galactosyltransferase activity 7/2948 32/18639 0.21875 1.38306690976934 0.233816530777227 0.723927136139946 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/2948 32/18639 0.21875 1.38306690976934 0.233816530777227 0.723927136139946 GO:0016798 hydrolase activity, acting on glycosyl bonds 24/2948 130/18639 0.184615384615385 1.16724767769544 0.235032803955239 0.723927136139946 GO:0005004 GPI-linked ephrin receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0005008 hepatocyte growth factor receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0005009 insulin receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0005011 macrophage colony-stimulating factor receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0005018 platelet-derived growth factor alpha-receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0005020 stem cell factor receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0008288 boss receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0036332 placental growth factor receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0038062 protein tyrosine kinase collagen receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0060175 brain-derived neurotrophic factor receptor activity 10/2948 49/18639 0.204081632653061 1.29032481377897 0.238940261271441 0.723927136139946 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0005024 transforming growth factor beta receptor activity 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0005159 insulin-like growth factor receptor binding 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0005521 lamin binding 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0008296 3'-5'-DNA exonuclease activity 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0055102 lipase inhibitor activity 4/2948 16/18639 0.25 1.58064789687924 0.239224480063227 0.723927136139946 GO:0008201 heparin binding 31/2948 172/18639 0.180232558139535 1.13953685588968 0.240665027277162 0.723927136139946 GO:0003713 transcription coactivator activity 45/2948 256/18639 0.17578125 1.11139305249322 0.241461416245375 0.723927136139946 GO:0000099 sulfur amino acid transmembrane transporter activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0008172 S-methyltransferase activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0008199 ferric iron binding 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0008526 phosphatidylinositol transfer activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0010854 adenylate cyclase regulator activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0034713 type I transforming growth factor beta receptor binding 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0045294 alpha-catenin binding 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0047676 arachidonate-CoA ligase activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0048185 activin binding 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0070697 activin receptor binding 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0140537 transcription regulator activator activity 3/2948 11/18639 0.272727272727273 1.7243431602319 0.246299794557087 0.723927136139946 GO:0022804 active transmembrane transporter activity 78/2948 457/18639 0.170678336980306 1.07912941756307 0.246652281969449 0.723927136139946 GO:0004683 calcium/calmodulin-dependent protein kinase activity 6/2948 27/18639 0.222222222222222 1.40502035278155 0.247019412102714 0.723927136139946 GO:0008320 protein transmembrane transporter activity 6/2948 27/18639 0.222222222222222 1.40502035278155 0.247019412102714 0.723927136139946 GO:0035255 ionotropic glutamate receptor binding 6/2948 27/18639 0.222222222222222 1.40502035278155 0.247019412102714 0.723927136139946 GO:0001223 transcription coactivator binding 9/2948 44/18639 0.204545454545455 1.29325737017392 0.25297008765586 0.736424032953726 GO:0019205 nucleobase-containing compound kinase activity 9/2948 44/18639 0.204545454545455 1.29325737017392 0.25297008765586 0.736424032953726 GO:0030547 signaling receptor inhibitor activity 9/2948 44/18639 0.204545454545455 1.29325737017392 0.25297008765586 0.736424032953726 GO:0005007 fibroblast growth factor receptor activity 10/2948 50/18639 0.2 1.26451831750339 0.259508203008645 0.748801202513932 GO:0005017 platelet-derived growth factor receptor activity 10/2948 50/18639 0.2 1.26451831750339 0.259508203008645 0.748801202513932 GO:0005019 platelet-derived growth factor beta-receptor activity 10/2948 50/18639 0.2 1.26451831750339 0.259508203008645 0.748801202513932 GO:0032813 tumor necrosis factor receptor superfamily binding 10/2948 50/18639 0.2 1.26451831750339 0.259508203008645 0.748801202513932 GO:0004175 endopeptidase activity 69/2948 405/18639 0.17037037037037 1.07718227046585 0.267239117732353 0.76941372358106 GO:0005543 phospholipid binding 84/2948 497/18639 0.169014084507042 1.06860702887611 0.268265316344698 0.770674483358673 GO:0051539 4 iron, 4 sulfur cluster binding 9/2948 45/18639 0.2 1.26451831750339 0.275306986445125 0.785623508642564 GO:0046875 ephrin receptor binding 6/2948 28/18639 0.214285714285714 1.35484105446792 0.275653586337095 0.785623508642564 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2948 17/18639 0.235294117647059 1.48766860882752 0.276609512214485 0.785623508642564 GO:0019198 transmembrane receptor protein phosphatase activity 4/2948 17/18639 0.235294117647059 1.48766860882752 0.276609512214485 0.785623508642564 GO:0038191 neuropilin binding 4/2948 17/18639 0.235294117647059 1.48766860882752 0.276609512214485 0.785623508642564 GO:0051020 GTPase binding 54/2948 315/18639 0.171428571428571 1.08387284357434 0.279504212385907 0.785623508642564 GO:0005010 insulin-like growth factor receptor activity 10/2948 51/18639 0.196078431372549 1.2397238406896 0.28062670189331 0.785623508642564 GO:0016830 carbon-carbon lyase activity 10/2948 51/18639 0.196078431372549 1.2397238406896 0.28062670189331 0.785623508642564 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 7/2948 34/18639 0.205882352941176 1.30171003272408 0.285623056077201 0.785623508642564 GO:0000340 RNA 7-methylguanosine cap binding 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0004126 cytidine deaminase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0015269 calcium-activated potassium channel activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0016840 carbon-nitrogen lyase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0031543 peptidyl-proline dioxygenase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0043047 single-stranded telomeric DNA binding 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:1990817 poly(A) RNA polymerase activity 3/2948 12/18639 0.25 1.58064789687924 0.292519683740859 0.785623508642564 GO:0044183 protein folding chaperone 14/2948 75/18639 0.186666666666667 1.1802170963365 0.292804584166923 0.785623508642564 GO:0004532 RNA exonuclease activity 8/2948 40/18639 0.2 1.26451831750339 0.292830008504974 0.785623508642564 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2948 40/18639 0.2 1.26451831750339 0.292830008504974 0.785623508642564 GO:0071949 FAD binding 8/2948 40/18639 0.2 1.26451831750339 0.292830008504974 0.785623508642564 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 5/2948 23/18639 0.217391304347826 1.3744764320689 0.293951596670786 0.785623508642564 GO:0005212 structural constituent of eye lens 5/2948 23/18639 0.217391304347826 1.3744764320689 0.293951596670786 0.785623508642564 GO:0016849 phosphorus-oxygen lyase activity 5/2948 23/18639 0.217391304347826 1.3744764320689 0.293951596670786 0.785623508642564 GO:0033192 calmodulin-dependent protein phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0140791 histone H2AXS140 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:1990439 MAP kinase serine/threonine phosphatase activity 15/2948 81/18639 0.185185185185185 1.17085029398462 0.294458887590457 0.785623508642564 GO:1990782 protein tyrosine kinase binding 21/2948 117/18639 0.179487179487179 1.13482413109279 0.298731844834983 0.795403895800462 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2948 29/18639 0.206896551724138 1.3081223974173 0.30500212151895 0.804697709426856 GO:0035250 UDP-galactosyltransferase activity 6/2948 29/18639 0.206896551724138 1.3081223974173 0.30500212151895 0.804697709426856 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/2948 29/18639 0.206896551724138 1.3081223974173 0.30500212151895 0.804697709426856 GO:0097472 cyclin-dependent protein kinase activity 6/2948 29/18639 0.206896551724138 1.3081223974173 0.30500212151895 0.804697709426856 GO:0008408 3'-5' exonuclease activity 11/2948 58/18639 0.189655172413793 1.19911219763253 0.3052937111337 0.804697709426856 GO:0005506 iron ion binding 27/2948 154/18639 0.175324675324675 1.10850631729193 0.310567893784225 0.808677986703508 GO:0003924 GTPase activity 56/2948 331/18639 0.169184290030211 1.06968316888504 0.311629388233617 0.808677986703508 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 15/2948 82/18639 0.182926829268293 1.15657163186286 0.311773882319559 0.808677986703508 GO:0033549 MAP kinase phosphatase activity 15/2948 82/18639 0.182926829268293 1.15657163186286 0.311773882319559 0.808677986703508 GO:0140789 histone phosphatase activity 24/2948 136/18639 0.176470588235294 1.11575145662064 0.312153653180631 0.808677986703508 GO:0000175 3'-5'-RNA exonuclease activity 7/2948 35/18639 0.2 1.26451831750339 0.312483778136645 0.808677986703508 GO:0042562 hormone binding 17/2948 94/18639 0.180851063829787 1.14344741476371 0.312947748513481 0.808677986703508 GO:0000400 four-way junction DNA binding 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0008308 voltage-gated monoatomic anion channel activity 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0031690 adrenergic receptor binding 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0050811 GABA receptor binding 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2948 18/18639 0.222222222222222 1.40502035278155 0.31482883451816 0.808677986703508 GO:0001530 lipopolysaccharide binding 8/2948 41/18639 0.195121951219512 1.23367640732038 0.317733481520831 0.814541801941856 GO:0005003 ephrin receptor activity 10/2948 53/18639 0.188679245283019 1.19294180896546 0.32419988227264 0.827878841670873 GO:0005005 transmembrane-ephrin receptor activity 10/2948 53/18639 0.188679245283019 1.19294180896546 0.32419988227264 0.827878841670873 GO:0045309 protein phosphorylated amino acid binding 11/2948 59/18639 0.186440677966102 1.17878826207943 0.326145447122346 0.829172339876122 GO:0070888 E-box binding 11/2948 59/18639 0.186440677966102 1.17878826207943 0.326145447122346 0.829172339876122 GO:0030552 cAMP binding 5/2948 24/18639 0.208333333333333 1.3172065807327 0.327238244057981 0.829172339876122 GO:0060229 lipase activator activity 5/2948 24/18639 0.208333333333333 1.3172065807327 0.327238244057981 0.829172339876122 GO:0003727 single-stranded RNA binding 16/2948 89/18639 0.179775280898876 1.13664567865473 0.329447322051122 0.83315828549608 GO:0022839 monoatomic ion-gated channel activity 6/2948 30/18639 0.2 1.26451831750339 0.334858723318273 0.836856867076449 GO:0033612 receptor serine/threonine kinase binding 6/2948 30/18639 0.2 1.26451831750339 0.334858723318273 0.836856867076449 GO:0002161 aminoacyl-tRNA editing activity 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0005035 death receptor activity 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0031432 titin binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0043560 insulin receptor substrate binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0045159 myosin II binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0070700 BMP receptor binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0089720 caspase binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:1901338 catecholamine binding 3/2948 13/18639 0.230769230769231 1.4590595971193 0.339214501082133 0.836856867076449 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 23/2948 132/18639 0.174242424242424 1.10166368570371 0.340533249471045 0.838531121817798 GO:0061630 ubiquitin protein ligase activity 59/2948 353/18639 0.1671388101983 1.05675043530737 0.342181160017412 0.841008104357992 GO:0016879 ligase activity, forming carbon-nitrogen bonds 9/2948 48/18639 0.1875 1.18548592265943 0.34514271438811 0.845115805324157 GO:0140693 molecular condensate scaffold activity 9/2948 48/18639 0.1875 1.18548592265943 0.34514271438811 0.845115805324157 GO:0004896 cytokine receptor activity 17/2948 96/18639 0.177083333333333 1.1196255936228 0.345979140980537 0.845583348291983 GO:0017018 myosin phosphatase activity 15/2948 84/18639 0.178571428571429 1.1290342120566 0.34715772799093 0.846883842957391 GO:0140104 molecular carrier activity 42/2948 249/18639 0.168674698795181 1.06646123162937 0.349445059412675 0.850879233885881 GO:0030246 carbohydrate binding 47/2948 280/18639 0.167857142857143 1.0612921593332 0.35156458646589 0.852684554693787 GO:0070851 growth factor receptor binding 24/2948 139/18639 0.172661870503597 1.09167048993099 0.353355459407422 0.852684554693787 GO:0008301 DNA binding, bending 4/2948 19/18639 0.210526315789474 1.33107191316147 0.353441002441776 0.852684554693787 GO:0050145 nucleoside monophosphate kinase activity 4/2948 19/18639 0.210526315789474 1.33107191316147 0.353441002441776 0.852684554693787 GO:0097001 ceramide binding 4/2948 19/18639 0.210526315789474 1.33107191316147 0.353441002441776 0.852684554693787 GO:0019787 ubiquitin-like protein transferase activity 79/2948 479/18639 0.164926931106472 1.04276562716877 0.35958717424158 0.865917643853806 GO:0003707 nuclear steroid receptor activity 5/2948 25/18639 0.2 1.26451831750339 0.360867145772864 0.867333999498257 GO:0004722 protein serine/threonine phosphatase activity 18/2948 103/18639 0.174757281553398 1.10491891820685 0.361499514294693 0.867333999498257 GO:0030280 structural constituent of skin epidermis 7/2948 37/18639 0.189189189189189 1.19616597601672 0.367351227316212 0.878982052553749 GO:0016500 protein-hormone receptor activity 12/2948 67/18639 0.17910447761194 1.13240446343587 0.368007355793713 0.878982052553749 GO:0004712 protein serine/threonine/tyrosine kinase activity 8/2948 43/18639 0.186046511627907 1.17629610930548 0.368560430787504 0.878982052553749 GO:0035254 glutamate receptor binding 9/2948 49/18639 0.183673469387755 1.16129233240107 0.36903826633936 0.878982052553749 GO:0008170 N-methyltransferase activity 17/2948 98/18639 0.173469387755102 1.09677609171213 0.37969639141011 0.891297598311128 GO:0005319 lipid transporter activity 30/2948 178/18639 0.168539325842697 1.06560532373881 0.382404937749612 0.891297598311128 GO:0050660 flavin adenine dinucleotide binding 15/2948 86/18639 0.174418604651163 1.10277760247389 0.383276008898957 0.891297598311128 GO:0005545 1-phosphatidylinositol binding 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0008494 translation activator activity 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0019992 diacylglycerol binding 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0042813 Wnt receptor activity 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0071933 Arp2/3 complex binding 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0098847 sequence-specific single stranded DNA binding 3/2948 14/18639 0.214285714285714 1.35484105446792 0.38567389117941 0.891297598311128 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 4/2948 20/18639 0.2 1.26451831750339 0.392043320322553 0.891297598311128 GO:0016004 phospholipase activator activity 4/2948 20/18639 0.2 1.26451831750339 0.392043320322553 0.891297598311128 GO:0016408 C-acyltransferase activity 4/2948 20/18639 0.2 1.26451831750339 0.392043320322553 0.891297598311128 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 4/2948 20/18639 0.2 1.26451831750339 0.392043320322553 0.891297598311128 GO:0031418 L-ascorbic acid binding 4/2948 20/18639 0.2 1.26451831750339 0.392043320322553 0.891297598311128 GO:0042393 histone binding 41/2948 247/18639 0.165991902834008 1.04949900845423 0.393646720982499 0.891297598311128 GO:0016755 aminoacyltransferase activity 81/2948 496/18639 0.163306451612903 1.03251999715499 0.394216469026546 0.891297598311128 GO:0005160 transforming growth factor beta receptor binding 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0008198 ferrous iron binding 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0030507 spectrin binding 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0050750 low-density lipoprotein particle receptor binding 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0051139 metal cation:proton antiporter activity 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0097602 cullin family protein binding 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0120014 phospholipid transfer activity 5/2948 26/18639 0.192307692307692 1.21588299759942 0.394571840573369 0.891297598311128 GO:0005109 frizzled binding 7/2948 38/18639 0.184210526315789 1.16468792401628 0.395059005737697 0.891297598311128 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 7/2948 38/18639 0.184210526315789 1.16468792401628 0.395059005737697 0.891297598311128 GO:0042162 telomeric DNA binding 7/2948 38/18639 0.184210526315789 1.16468792401628 0.395059005737697 0.891297598311128 GO:0022884 macromolecule transmembrane transporter activity 6/2948 32/18639 0.1875 1.18548592265943 0.395300690548676 0.891297598311128 GO:0043425 bHLH transcription factor binding 6/2948 32/18639 0.1875 1.18548592265943 0.395300690548676 0.891297598311128 GO:0120015 sterol transfer activity 6/2948 32/18639 0.1875 1.18548592265943 0.395300690548676 0.891297598311128 GO:0140142 nucleocytoplasmic carrier activity 6/2948 32/18639 0.1875 1.18548592265943 0.395300690548676 0.891297598311128 GO:0001664 G protein-coupled receptor binding 49/2948 297/18639 0.164983164983165 1.04312117100448 0.397006128990857 0.89360486078698 GO:0051219 phosphoprotein binding 16/2948 93/18639 0.172043010752688 1.08775769247604 0.399092426235368 0.896759997201256 GO:0030971 receptor tyrosine kinase binding 14/2948 81/18639 0.172839506172839 1.09279360771898 0.403978884926065 0.90618551241977 GO:0003725 double-stranded RNA binding 13/2948 75/18639 0.173333333333333 1.09591587516961 0.40650585294339 0.910295157873232 GO:0008013 beta-catenin binding 18/2948 106/18639 0.169811320754717 1.07364762806892 0.41100191871931 0.918792685191632 GO:0016410 N-acyltransferase activity 16/2948 94/18639 0.170212765957447 1.07618580213055 0.416763129357806 0.930084666880284 GO:0008234 cysteine-type peptidase activity 31/2948 187/18639 0.165775401069519 1.04813015621939 0.417746379568433 0.930693464684774 GO:0140303 intramembrane lipid transporter activity 8/2948 45/18639 0.177777777777778 1.12401628222524 0.419963970951166 0.934045504152849 GO:0019239 deaminase activity 6/2948 33/18639 0.181818181818182 1.14956210682127 0.425512132632237 0.935448336892791 GO:0004364 glutathione transferase activity 5/2948 27/18639 0.185185185185185 1.17085029398462 0.428106483407608 0.935448336892791 GO:0008266 poly(U) RNA binding 5/2948 27/18639 0.185185185185185 1.17085029398462 0.428106483407608 0.935448336892791 GO:0001846 opsonin binding 4/2948 21/18639 0.19047619047619 1.20430315952704 0.43027696102362 0.935448336892791 GO:0010314 phosphatidylinositol-5-phosphate binding 4/2948 21/18639 0.19047619047619 1.20430315952704 0.43027696102362 0.935448336892791 GO:0019200 carbohydrate kinase activity 4/2948 21/18639 0.19047619047619 1.20430315952704 0.43027696102362 0.935448336892791 GO:0051010 microtubule plus-end binding 4/2948 21/18639 0.19047619047619 1.20430315952704 0.43027696102362 0.935448336892791 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0005041 low-density lipoprotein particle receptor activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0008252 nucleotidase activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0016846 carbon-sulfur lyase activity 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0031005 filamin binding 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0120283 protein serine/threonine kinase binding 3/2948 15/18639 0.2 1.26451831750339 0.431305950750569 0.935448336892791 GO:0140662 ATP-dependent protein folding chaperone 7/2948 40/18639 0.175 1.10645352781547 0.450320554109164 0.970075681470182 GO:0016407 acetyltransferase activity 16/2948 96/18639 0.166666666666667 1.05376526458616 0.452161924903342 0.970075681470182 GO:0003697 single-stranded DNA binding 20/2948 121/18639 0.165289256198347 1.04505646074661 0.452837448481692 0.970075681470182 GO:0038024 cargo receptor activity 11/2948 65/18639 0.169230769230769 1.06997703788749 0.45489162877611 0.970075681470182 GO:0008376 acetylgalactosaminyltransferase activity 6/2948 34/18639 0.176470588235294 1.11575145662064 0.455488363322601 0.970075681470182 GO:0052866 phosphatidylinositol phosphate phosphatase activity 6/2948 34/18639 0.176470588235294 1.11575145662064 0.455488363322601 0.970075681470182 GO:0036002 pre-mRNA binding 10/2948 59/18639 0.169491525423729 1.07162569279948 0.459825436690096 0.970075681470182 GO:0016866 intramolecular transferase activity 5/2948 28/18639 0.178571428571429 1.1290342120566 0.461248417553372 0.970075681470182 GO:0046625 sphingolipid binding 5/2948 28/18639 0.178571428571429 1.1290342120566 0.461248417553372 0.970075681470182 GO:0051959 dynein light intermediate chain binding 5/2948 28/18639 0.178571428571429 1.1290342120566 0.461248417553372 0.970075681470182 GO:0034212 protein N-acetyltransferase activity 9/2948 53/18639 0.169811320754717 1.07364762806892 0.465180767427692 0.970075681470182 GO:0008970 phospholipase A1 activity 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0033691 sialic acid binding 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0034062 5'-3' RNA polymerase activity 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0097747 RNA polymerase activity 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0140517 protein-RNA adaptor activity 4/2948 22/18639 0.181818181818182 1.14956210682127 0.467829496119045 0.970075681470182 GO:0042379 chemokine receptor binding 12/2948 72/18639 0.166666666666667 1.05376526458616 0.470821134598022 0.970075681470182 GO:0043495 protein-membrane adaptor activity 8/2948 47/18639 0.170212765957447 1.07618580213055 0.471061707110814 0.970075681470182 GO:0061733 protein-lysine-acetyltransferase activity 8/2948 47/18639 0.170212765957447 1.07618580213055 0.471061707110814 0.970075681470182 GO:0008168 methyltransferase activity 33/2948 204/18639 0.161764705882353 1.02277216856892 0.473370126887304 0.970075681470182 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0004708 MAP kinase kinase activity 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0005149 interleukin-1 receptor binding 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0097027 ubiquitin-protein transferase activator activity 3/2948 16/18639 0.1875 1.18548592265943 0.475632443986109 0.970075681470182 GO:0042169 SH2 domain binding 7/2948 41/18639 0.170731707317073 1.07946685640533 0.477617892583233 0.970075681470182 GO:0140318 protein transporter activity 7/2948 41/18639 0.170731707317073 1.07946685640533 0.477617892583233 0.970075681470182 GO:0010485 histone H4 acetyltransferase activity 6/2948 35/18639 0.171428571428571 1.08387284357434 0.485075518878316 0.970075681470182 GO:0004090 carbonyl reductase (NADPH) activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0004935 adrenergic receptor activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0008140 cAMP response element binding protein binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0008190 eukaryotic initiation factor 4E binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0008239 dipeptidyl-peptidase activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0008401 retinoic acid 4-hydroxylase activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0015279 store-operated calcium channel activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0035256 G protein-coupled glutamate receptor binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0043121 neurotrophin binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0043422 protein kinase B binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0045322 unmethylated CpG binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0051378 serotonin binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0051880 G-quadruplex DNA binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0098505 G-rich strand telomeric DNA binding 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0140135 mechanosensitive monoatomic cation channel activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0141109 transporter activator activity 2/2948 10/18639 0.2 1.26451831750339 0.485417762261765 0.970075681470182 GO:0046982 protein heterodimerization activity 59/2948 369/18639 0.159891598915989 1.01092927822087 0.485778356522473 0.970075681470182 GO:0003925 G protein activity 9/2948 54/18639 0.166666666666667 1.05376526458616 0.488918289326122 0.974859907179938 GO:0016779 nucleotidyltransferase activity 22/2948 136/18639 0.161764705882353 1.02277216856892 0.490324098771543 0.976177157128756 GO:0005126 cytokine receptor binding 44/2948 275/18639 0.16 1.01161465400271 0.492288497208151 0.97860080628631 GO:0140102 catalytic activity, acting on a rRNA 4/2948 23/18639 0.173913043478261 1.09958114565512 0.504435369687099 0.989029778263266 GO:0140103 catalytic activity, acting on a glycoprotein 4/2948 23/18639 0.173913043478261 1.09958114565512 0.504435369687099 0.989029778263266 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/2948 23/18639 0.173913043478261 1.09958114565512 0.504435369687099 0.989029778263266 GO:0004402 histone acetyltransferase activity 7/2948 42/18639 0.166666666666667 1.05376526458616 0.504538101465951 0.989029778263266 GO:0042056 chemoattractant activity 7/2948 42/18639 0.166666666666667 1.05376526458616 0.504538101465951 0.989029778263266 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/2948 61/18639 0.163934426229508 1.03649042418311 0.504626633429003 0.989029778263266 GO:0004721 phosphoprotein phosphatase activity 28/2948 175/18639 0.16 1.01161465400271 0.505491124980101 0.989029778263266 GO:0051213 dioxygenase activity 15/2948 93/18639 0.161290322580645 1.01977283669628 0.510828143967638 0.989029778263266 GO:0035064 methylated histone binding 12/2948 74/18639 0.162162162162162 1.02528512230005 0.511417218457452 0.989029778263266 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0004550 nucleoside diphosphate kinase activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0008484 sulfuric ester hydrolase activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0008569 minus-end-directed microtubule motor activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0015278 intracellularly gated calcium channel activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0015347 sodium-independent organic anion transmembrane transporter activity 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0016018 cyclosporin A binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0030169 low-density lipoprotein particle binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0031489 myosin V binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0032183 SUMO binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0036041 long-chain fatty acid binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0045236 CXCR chemokine receptor binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0048038 quinone binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0070403 NAD+ binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0070492 oligosaccharide binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:1990226 histone methyltransferase binding 3/2948 17/18639 0.176470588235294 1.11575145662064 0.518280215080029 0.989029778263266 GO:0030145 manganese ion binding 11/2948 68/18639 0.161764705882353 1.02277216856892 0.518674395165545 0.989029778263266 GO:1990841 promoter-specific chromatin binding 11/2948 68/18639 0.161764705882353 1.02277216856892 0.518674395165545 0.989029778263266 GO:0016763 pentosyltransferase activity 8/2948 49/18639 0.163265306122449 1.03225985102318 0.521066430399938 0.989141232454447 GO:0004842 ubiquitin-protein transferase activity 71/2948 449/18639 0.158129175946548 0.999786197580633 0.521237109983287 0.989141232454447 GO:0001217 DNA-binding transcription repressor activity 44/2948 278/18639 0.158273381294964 1.0006979491034 0.523689667251267 0.989141232454447 GO:0008187 poly-pyrimidine tract binding 5/2948 30/18639 0.166666666666667 1.05376526458616 0.525587930408997 0.989141232454447 GO:0015215 nucleotide transmembrane transporter activity 5/2948 30/18639 0.166666666666667 1.05376526458616 0.525587930408997 0.989141232454447 GO:0048019 receptor antagonist activity 5/2948 30/18639 0.166666666666667 1.05376526458616 0.525587930408997 0.989141232454447 GO:0098918 structural constituent of synapse 5/2948 30/18639 0.166666666666667 1.05376526458616 0.525587930408997 0.989141232454447 GO:0170055 lipid transmembrane transporter activity 9/2948 56/18639 0.160714285714286 1.01613079085094 0.535488137249049 0.989141232454447 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0001851 complement component C3b binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0004016 adenylate cyclase activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0005114 type II transforming growth factor beta receptor binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0008046 axon guidance receptor activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0016594 glycine binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0019206 nucleoside kinase activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0034056 estrogen response element binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0034511 U3 snoRNA binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0140031 phosphorylation-dependent protein binding 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0180030 inositol phosphate kinase activity 2/2948 11/18639 0.181818181818182 1.14956210682127 0.53855508841836 0.989141232454447 GO:0008080 N-acetyltransferase activity 11/2948 69/18639 0.159420289855072 1.0079493835172 0.539457552876248 0.989141232454447 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/2948 24/18639 0.166666666666667 1.05376526458616 0.539874794812923 0.989141232454447 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/2948 24/18639 0.166666666666667 1.05376526458616 0.539874794812923 0.989141232454447 GO:0005540 hyaluronic acid binding 4/2948 24/18639 0.166666666666667 1.05376526458616 0.539874794812923 0.989141232454447 GO:0030551 cyclic nucleotide binding 6/2948 37/18639 0.162162162162162 1.02528512230005 0.542545005085235 0.992645190868237 GO:0004867 serine-type endopeptidase inhibitor activity 15/2948 95/18639 0.157894736842105 0.998303934871099 0.546355551441523 0.996832552072973 GO:0008276 protein methyltransferase activity 15/2948 95/18639 0.157894736842105 0.998303934871099 0.546355551441523 0.996832552072973 GO:0140034 methylation-dependent protein binding 12/2948 76/18639 0.157894736842105 0.998303934871099 0.551114409071009 1 GO:0008238 exopeptidase activity 16/2948 102/18639 0.156862745098039 0.99177907255168 0.556386686175792 1 GO:0047499 calcium-independent phospholipase A2 activity 5/2948 31/18639 0.161290322580645 1.01977283669628 0.55646591498928 1 GO:0070325 lipoprotein particle receptor binding 5/2948 31/18639 0.161290322580645 1.01977283669628 0.55646591498928 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0008525 phosphatidylcholine transporter activity 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0016854 racemase and epimerase activity 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0017075 syntaxin-1 binding 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0030228 lipoprotein particle receptor activity 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0034185 apolipoprotein binding 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0070628 proteasome binding 3/2948 18/18639 0.166666666666667 1.05376526458616 0.558970491192402 1 GO:0016278 lysine N-methyltransferase activity 11/2948 70/18639 0.157142857142857 0.993550106609808 0.559919126774288 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 26/2948 167/18639 0.155688622754491 0.984355576499647 0.567996186207766 1 GO:0015662 P-type ion transporter activity 4/2948 25/18639 0.16 1.01161465400271 0.573971489868172 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/2948 25/18639 0.16 1.01161465400271 0.573971489868172 1 GO:0047617 fatty acyl-CoA hydrolase activity 4/2948 25/18639 0.16 1.01161465400271 0.573971489868172 1 GO:0140358 P-type transmembrane transporter activity 4/2948 25/18639 0.16 1.01161465400271 0.573971489868172 1 GO:0004527 exonuclease activity 13/2948 84/18639 0.154761904761905 0.97849631711572 0.580299648316111 1 GO:0008009 chemokine activity 7/2948 45/18639 0.155555555555556 0.983514246947083 0.582061391123865 1 GO:0047498 calcium-dependent phospholipase A2 activity 5/2948 32/18639 0.15625 0.987904935549525 0.586311326922724 1 GO:0070717 poly-purine tract binding 5/2948 32/18639 0.15625 0.987904935549525 0.586311326922724 1 GO:0071813 lipoprotein particle binding 5/2948 32/18639 0.15625 0.987904935549525 0.586311326922724 1 GO:0071814 protein-lipid complex binding 5/2948 32/18639 0.15625 0.987904935549525 0.586311326922724 1 GO:0008083 growth factor activity 25/2948 162/18639 0.154320987654321 0.975708578320519 0.58689299669454 1 GO:0003995 acyl-CoA dehydrogenase activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0004000 adenosine deaminase activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0004875 complement receptor activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0005078 MAP-kinase scaffold activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0005095 GTPase inhibitor activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0008179 adenylate cyclase binding 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0010853 cyclase activator activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0015368 calcium:monoatomic cation antiporter activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0016208 AMP binding 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0016273 arginine N-methyltransferase activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0016274 protein-arginine N-methyltransferase activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0042301 phosphate ion binding 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:1990459 transferrin receptor binding 2/2948 12/18639 0.166666666666667 1.05376526458616 0.58776216935386 1 GO:0160215 deacylase activity 10/2948 65/18639 0.153846153846154 0.972706398079533 0.590476357660213 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 54/2948 349/18639 0.154727793696275 0.978280646779129 0.593367317996422 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:0030506 ankyrin binding 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:0042834 peptidoglycan binding 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:1990380 K48-linked deubiquitinase activity 3/2948 19/18639 0.157894736842105 0.998303934871099 0.597507270333145 1 GO:0030527 structural constituent of chromatin 15/2948 98/18639 0.153061224489796 0.967743610334229 0.597903070974559 1 GO:0016922 nuclear receptor binding 21/2948 137/18639 0.153284671532847 0.969156374728877 0.598578638197441 1 GO:0070063 RNA polymerase binding 9/2948 59/18639 0.152542372881356 0.964463123519536 0.602120257841422 1 GO:0016741 transferase activity, transferring one-carbon groups 33/2948 215/18639 0.153488372093023 0.970444290177022 0.603873415131531 1 GO:0030276 clathrin binding 7/2948 46/18639 0.152173913043478 0.962133502448233 0.60655395755106 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0004529 DNA exonuclease activity 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0008143 poly(A) binding 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0016289 acyl-CoA hydrolase activity 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0050681 nuclear androgen receptor binding 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0070006 metalloaminopeptidase activity 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0070412 R-SMAD binding 4/2948 26/18639 0.153846153846154 0.972706398079533 0.606589607921773 1 GO:0140416 transcription regulator inhibitor activity 5/2948 33/18639 0.151515151515152 0.957968422351055 0.615025468760311 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 8/2948 53/18639 0.150943396226415 0.954353447172371 0.615243890558378 1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 13/2948 86/18639 0.151162790697674 0.955740588810703 0.616232156897511 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 41/2948 268/18639 0.152985074626866 0.967262145851475 0.61840358969286 1 GO:0004177 aminopeptidase activity 6/2948 40/18639 0.15 0.948388738127544 0.622891321709165 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 6/2948 40/18639 0.15 0.948388738127544 0.622891321709165 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/2948 60/18639 0.15 0.948388738127544 0.623259053171263 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/2948 60/18639 0.15 0.948388738127544 0.623259053171263 1 GO:0001784 phosphotyrosine residue binding 7/2948 47/18639 0.148936170212766 0.941662576864228 0.630265101378103 1 GO:0043130 ubiquitin binding 15/2948 100/18639 0.15 0.948388738127544 0.630799232124093 1 GO:1901981 phosphatidylinositol phosphate binding 28/2948 185/18639 0.151351351351351 0.956932780813378 0.631674425054159 1 GO:0004993 G protein-coupled serotonin receptor activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0005172 vascular endothelial growth factor receptor binding 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0008035 high-density lipoprotein particle binding 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0008253 5'-nucleotidase activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0009982 pseudouridine synthase activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0032396 inhibitory MHC class I receptor activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0061459 L-arginine transmembrane transporter activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0140333 glycerophospholipid flippase activity 2/2948 13/18639 0.153846153846154 0.972706398079533 0.632952654494174 1 GO:0000339 RNA cap binding 3/2948 20/18639 0.15 0.948388738127544 0.633765614452662 1 GO:0001614 purinergic nucleotide receptor activity 3/2948 20/18639 0.15 0.948388738127544 0.633765614452662 1 GO:0010851 cyclase regulator activity 3/2948 20/18639 0.15 0.948388738127544 0.633765614452662 1 GO:0016502 nucleotide receptor activity 3/2948 20/18639 0.15 0.948388738127544 0.633765614452662 1 GO:0052745 inositol phosphate phosphatase activity 3/2948 20/18639 0.15 0.948388738127544 0.633765614452662 1 GO:0030695 GTPase regulator activity 75/2948 489/18639 0.153374233128834 0.969722636122233 0.634925602856927 1 GO:0032182 ubiquitin-like protein binding 18/2948 120/18639 0.15 0.948388738127544 0.63546043009041 1 GO:0017069 snRNA binding 8/2948 54/18639 0.148148148148148 0.936680235187698 0.637213560337901 1 GO:0005044 scavenger receptor activity 4/2948 27/18639 0.148148148148148 0.936680235187698 0.637630151315541 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2948 27/18639 0.148148148148148 0.936680235187698 0.637630151315541 1 GO:0031267 small GTPase binding 43/2948 283/18639 0.151943462897526 0.960676460294096 0.63875696045172 1 GO:0060589 nucleoside-triphosphatase regulator activity 75/2948 490/18639 0.153061224489796 0.967743610334229 0.642303080213854 1 GO:0019825 oxygen binding 5/2948 34/18639 0.147058823529412 0.9297928805172 0.642531866249572 1 GO:0001727 lipid kinase activity 6/2948 41/18639 0.146341463414634 0.925257305490287 0.647795338130753 1 GO:0008227 G protein-coupled amine receptor activity 6/2948 41/18639 0.146341463414634 0.925257305490287 0.647795338130753 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/2948 41/18639 0.146341463414634 0.925257305490287 0.647795338130753 1 GO:0140828 metal cation:monoatomic cation antiporter activity 6/2948 41/18639 0.146341463414634 0.925257305490287 0.647795338130753 1 GO:0140597 protein carrier chaperone 28/2948 188/18639 0.148936170212766 0.941662576864228 0.666624331883097 1 GO:0036408 histone H3K14 acetyltransferase activity 4/2948 28/18639 0.142857142857143 0.90322736964528 0.667027106942569 1 GO:0045499 chemorepellent activity 4/2948 28/18639 0.142857142857143 0.90322736964528 0.667027106942569 1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2948 28/18639 0.142857142857143 0.90322736964528 0.667027106942569 1 GO:0015174 basic amino acid transmembrane transporter activity 3/2948 21/18639 0.142857142857143 0.90322736964528 0.667680390024168 1 GO:0035613 RNA stem-loop binding 3/2948 21/18639 0.142857142857143 0.90322736964528 0.667680390024168 1 GO:0036122 BMP binding 3/2948 21/18639 0.142857142857143 0.90322736964528 0.667680390024168 1 GO:0051428 peptide hormone receptor binding 3/2948 21/18639 0.142857142857143 0.90322736964528 0.667680390024168 1 GO:1904047 S-adenosyl-L-methionine binding 3/2948 21/18639 0.142857142857143 0.90322736964528 0.667680390024168 1 GO:0005125 cytokine activity 35/2948 234/18639 0.14957264957265 0.945686775910656 0.668697244171529 1 GO:0004623 phospholipase A2 activity 5/2948 35/18639 0.142857142857143 0.90322736964528 0.668774590811448 1 GO:0043015 gamma-tubulin binding 5/2948 35/18639 0.142857142857143 0.90322736964528 0.668774590811448 1 GO:0061631 ubiquitin conjugating enzyme activity 5/2948 35/18639 0.142857142857143 0.90322736964528 0.668774590811448 1 GO:0140566 histone reader activity 5/2948 35/18639 0.142857142857143 0.90322736964528 0.668774590811448 1 GO:0016279 protein-lysine N-methyltransferase activity 10/2948 69/18639 0.144927536231884 0.91631762137927 0.668787514512257 1 GO:0048487 beta-tubulin binding 6/2948 42/18639 0.142857142857143 0.90322736964528 0.671671544241554 1 GO:0004065 arylsulfatase activity 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0005313 L-glutamate transmembrane transporter activity 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0005344 oxygen carrier activity 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0005347 ATP transmembrane transporter activity 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0043176 amine binding 2/2948 14/18639 0.142857142857143 0.90322736964528 0.674165781713302 1 GO:0030170 pyridoxal phosphate binding 8/2948 56/18639 0.142857142857143 0.90322736964528 0.678957951410515 1 GO:0005085 guanyl-nucleotide exchange factor activity 34/2948 230/18639 0.147826086956522 0.934643973806855 0.694357770848008 1 GO:0010484 histone H3 acetyltransferase activity 4/2948 29/18639 0.137931034482759 0.872081598278201 0.694743487377026 1 GO:0016417 S-acyltransferase activity 4/2948 29/18639 0.137931034482759 0.872081598278201 0.694743487377026 1 GO:0099604 ligand-gated calcium channel activity 4/2948 29/18639 0.137931034482759 0.872081598278201 0.694743487377026 1 GO:0048020 CCR chemokine receptor binding 7/2948 50/18639 0.14 0.885162822252375 0.696276287159755 1 GO:1902936 phosphatidylinositol bisphosphate binding 16/2948 111/18639 0.144144144144144 0.911364553155598 0.696655409301927 1 GO:0070279 vitamin B6 binding 8/2948 57/18639 0.140350877192982 0.887381275440977 0.698675760669386 1 GO:0005243 gap junction channel activity 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0008093 cytoskeletal anchor activity 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0008649 rRNA methyltransferase activity 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0015377 chloride:monoatomic cation symporter activity 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0140035 ubiquitin-like protein reader activity 3/2948 22/18639 0.136363636363636 0.862171580115949 0.699235794324977 1 GO:0046906 tetrapyrrole binding 22/2948 152/18639 0.144736842105263 0.915111940298508 0.708726550430453 1 GO:0004089 carbonate dehydratase activity 2/2948 15/18639 0.133333333333333 0.843012211668928 0.711528832630645 1 GO:0004953 icosanoid receptor activity 2/2948 15/18639 0.133333333333333 0.843012211668928 0.711528832630645 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2948 15/18639 0.133333333333333 0.843012211668928 0.711528832630645 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2948 15/18639 0.133333333333333 0.843012211668928 0.711528832630645 1 GO:0051371 muscle alpha-actinin binding 2/2948 15/18639 0.133333333333333 0.843012211668928 0.711528832630645 1 GO:0019213 deacetylase activity 5/2948 37/18639 0.135135135135135 0.854404268583373 0.717336962263044 1 GO:0140030 modification-dependent protein binding 25/2948 173/18639 0.144508670520231 0.913669304554474 0.720316695395411 1 GO:0001965 G-protein alpha-subunit binding 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0043995 histone H4K5 acetyltransferase activity 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0043996 histone H4K8 acetyltransferase activity 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0043997 histone H4K12 acetyltransferase activity 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0051721 protein phosphatase 2A binding 4/2948 30/18639 0.133333333333333 0.843012211668928 0.720767419218262 1 GO:0000295 adenine nucleotide transmembrane transporter activity 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0008171 O-methyltransferase activity 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0017134 fibroblast growth factor binding 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0044013 histone H2B acetyltransferase activity 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0070577 lysine-acetylated histone binding 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0099186 structural constituent of postsynapse 3/2948 23/18639 0.130434782608696 0.824685859241343 0.728455858020659 1 GO:0019783 ubiquitin-like protein peptidase activity 18/2948 127/18639 0.141732283464567 0.89611534311264 0.730463569526822 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 26/2948 181/18639 0.143646408839779 0.908217576107409 0.734473421262273 1 GO:0000146 microfilament motor activity 5/2948 38/18639 0.131578947368421 0.831919945725916 0.739630648975187 1 GO:0005164 tumor necrosis factor receptor binding 4/2948 31/18639 0.129032258064516 0.815818269357027 0.74510838280774 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/2948 31/18639 0.129032258064516 0.815818269357027 0.74510838280774 1 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2948 31/18639 0.129032258064516 0.815818269357027 0.74510838280774 1 GO:0015378 sodium:chloride symporter activity 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0015385 sodium:proton antiporter activity 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0015923 mannosidase activity 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0016722 oxidoreductase activity, acting on metal ions 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0017070 U6 snRNA binding 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0140327 flippase activity 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0140328 floppase activity 2/2948 16/18639 0.125 0.79032394843962 0.745228316722722 1 GO:0042054 histone methyltransferase activity 9/2948 67/18639 0.134328358208955 0.849303347576905 0.752805169346484 1 GO:0017046 peptide hormone binding 7/2948 53/18639 0.132075471698113 0.835059266275825 0.754083837012717 1 GO:0004622 lysophospholipase activity 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0004806 triacylglycerol lipase activity 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0005315 phosphate transmembrane transporter activity 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0030215 semaphorin receptor binding 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0050699 WW domain binding 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0140033 acetylation-dependent protein binding 3/2948 24/18639 0.125 0.79032394843962 0.755396009907478 1 GO:0004180 carboxypeptidase activity 6/2948 46/18639 0.130434782608696 0.824685859241343 0.756404840343791 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2948 46/18639 0.130434782608696 0.824685859241343 0.756404840343791 1 GO:0035091 phosphatidylinositol binding 41/2948 284/18639 0.144366197183099 0.912768503831674 0.762800176013095 1 GO:0005096 GTPase activator activity 39/2948 271/18639 0.143911439114391 0.909893254292109 0.765105039875155 1 GO:0003777 microtubule motor activity 9/2948 68/18639 0.132352941176471 0.83681359246548 0.768480595580652 1 GO:0140223 general transcription initiation factor activity 9/2948 68/18639 0.132352941176471 0.83681359246548 0.768480595580652 1 GO:0015026 coreceptor activity 8/2948 61/18639 0.131147540983607 0.829192339346487 0.769498213146021 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/2948 54/18639 0.12962962962963 0.819595205789236 0.771490048432371 1 GO:0140938 histone H3 methyltransferase activity 6/2948 47/18639 0.127659574468085 0.80713935159791 0.774864314338769 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0008429 phosphatidylethanolamine binding 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0016805 dipeptidase activity 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0030548 acetylcholine receptor regulator activity 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0046965 nuclear retinoid X receptor binding 2/2948 17/18639 0.117647058823529 0.74383430441376 0.775488063608414 1 GO:0004709 MAP kinase kinase kinase activity 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0008139 nuclear localization sequence binding 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0019707 protein-cysteine S-acyltransferase activity 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0120020 cholesterol transfer activity 3/2948 25/18639 0.12 0.758710990502035 0.780135717185565 1 GO:0032451 demethylase activity 5/2948 40/18639 0.125 0.79032394843962 0.78027827428311 1 GO:0071855 neuropeptide receptor binding 5/2948 40/18639 0.125 0.79032394843962 0.78027827428311 1 GO:0008194 UDP-glycosyltransferase activity 20/2948 145/18639 0.137931034482759 0.872081598278201 0.780712643361169 1 GO:0019956 chemokine binding 4/2948 33/18639 0.121212121212121 0.766374737880844 0.788865153435984 1 GO:0071889 14-3-3 protein binding 4/2948 33/18639 0.121212121212121 0.766374737880844 0.788865153435984 1 GO:0032266 phosphatidylinositol-3-phosphate binding 6/2948 48/18639 0.125 0.79032394843962 0.792252574134337 1 GO:0003774 cytoskeletal motor activity 21/2948 153/18639 0.137254901960784 0.86780668848272 0.792447215081281 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 12/2948 91/18639 0.131868131868132 0.833748341211028 0.794822972229349 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 9/2948 70/18639 0.128571428571429 0.812904632680752 0.797672603764697 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 5/2948 41/18639 0.121951219512195 0.771047754575239 0.798678682082049 1 GO:0042287 MHC protein binding 5/2948 41/18639 0.121951219512195 0.771047754575239 0.798678682082049 1 GO:0015085 calcium ion transmembrane transporter activity 20/2948 147/18639 0.136054421768707 0.860216542519314 0.800705874366848 1 GO:0003746 translation elongation factor activity 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0004706 JUN kinase kinase kinase activity 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0015373 monoatomic anion:sodium symporter activity 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0099602 neurotransmitter receptor regulator activity 2/2948 18/18639 0.111111111111111 0.702510176390773 0.802552760160416 1 GO:0008157 protein phosphatase 1 binding 3/2948 26/18639 0.115384615384615 0.729529798559649 0.802772166219973 1 GO:0015216 purine nucleotide transmembrane transporter activity 3/2948 26/18639 0.115384615384615 0.729529798559649 0.802772166219973 1 GO:0019865 immunoglobulin binding 3/2948 26/18639 0.115384615384615 0.729529798559649 0.802772166219973 1 GO:0052742 phosphatidylinositol kinase activity 3/2948 26/18639 0.115384615384615 0.729529798559649 0.802772166219973 1 GO:0008175 tRNA methyltransferase activity 4/2948 34/18639 0.117647058823529 0.74383430441376 0.808376258394172 1 GO:0035198 miRNA binding 5/2948 42/18639 0.119047619047619 0.7526894747044 0.815841808817251 1 GO:0020037 heme binding 19/2948 142/18639 0.133802816901408 0.845980564526917 0.818646785317315 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0003796 lysozyme activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0004955 prostaglandin receptor activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0008519 ammonium channel activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0015187 glycine transmembrane transporter activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0015203 polyamine transmembrane transporter activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0016783 sulfurtransferase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0019531 oxalate transmembrane transporter activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0031720 haptoglobin binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0035374 chondroitin sulfate binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0042166 acetylcholine binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0043208 glycosphingolipid binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0043295 glutathione binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0051864 histone H3K36 demethylase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0070513 death domain binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0140940 histone H2A methyltransferase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0140999 histone H3K4 trimethyltransferase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:1905394 retromer complex binding 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/2948 10/18639 0.1 0.632259158751696 0.82131706629 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/2948 27/18639 0.111111111111111 0.702510176390773 0.823414918083027 1 GO:0015605 organophosphate ester transmembrane transporter activity 6/2948 50/18639 0.12 0.758710990502035 0.823906750815264 1 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0008574 plus-end-directed microtubule motor activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0022840 leak channel activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0022842 narrow pore channel activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0042800 histone H3K4 methyltransferase activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0099589 serotonin receptor activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0140036 ubiquitin-modified protein reader activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:0141147 intracellularly calcium-gated channel activity 2/2948 19/18639 0.105263157894737 0.665535956580733 0.826675758963624 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 16/2948 122/18639 0.131147540983607 0.829192339346487 0.827069013201776 1 GO:0016791 phosphatase activity 38/2948 273/18639 0.139194139194139 0.880067693500529 0.82826659371882 1 GO:0008081 phosphoric diester hydrolase activity 11/2948 87/18639 0.126436781609195 0.799408131755018 0.831136512182144 1 GO:0005048 signal sequence binding 6/2948 51/18639 0.117647058823529 0.74383430441376 0.838230877017626 1 GO:0005272 sodium channel activity 6/2948 51/18639 0.117647058823529 0.74383430441376 0.838230877017626 1 GO:0008235 metalloexopeptidase activity 8/2948 66/18639 0.121212121212121 0.766374737880844 0.840003448081567 1 GO:0046966 nuclear thyroid hormone receptor binding 3/2948 28/18639 0.107142857142857 0.67742052723396 0.842181455419882 1 GO:0051393 alpha-actinin binding 3/2948 28/18639 0.107142857142857 0.67742052723396 0.842181455419882 1 GO:0141052 histone H3 demethylase activity 3/2948 28/18639 0.107142857142857 0.67742052723396 0.842181455419882 1 GO:0005484 SNAP receptor activity 4/2948 36/18639 0.111111111111111 0.702510176390773 0.842973495452275 1 GO:0016409 palmitoyltransferase activity 4/2948 36/18639 0.111111111111111 0.702510176390773 0.842973495452275 1 GO:0015101 organic cation transmembrane transporter activity 10/2948 81/18639 0.123456790123457 0.780566862656415 0.844462377916495 1 GO:0031593 polyubiquitin modification-dependent protein binding 7/2948 59/18639 0.11864406779661 0.750137984959639 0.845008374955777 1 GO:0005262 calcium channel activity 17/2948 131/18639 0.129770992366412 0.820488984639606 0.845124817098655 1 GO:0016790 thiolester hydrolase activity 5/2948 44/18639 0.113636363636364 0.718476316763291 0.846628846138199 1 GO:0004222 metalloendopeptidase activity 14/2948 110/18639 0.127272727272727 0.804693474774886 0.847140987467209 1 GO:0015095 magnesium ion transmembrane transporter activity 2/2948 20/18639 0.1 0.632259158751696 0.848110219464842 1 GO:0061608 nuclear import signal receptor activity 2/2948 20/18639 0.1 0.632259158751696 0.848110219464842 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0004954 prostanoid receptor activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0015217 ADP transmembrane transporter activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0019864 IgG binding 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0032050 clathrin heavy chain binding 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0043522 leucine zipper domain binding 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:1900750 oligopeptide binding 1/2948 11/18639 0.0909090909090909 0.574781053410633 0.849593264077164 1 GO:0030159 signaling receptor complex adaptor activity 6/2948 52/18639 0.115384615384615 0.729529798559649 0.851598406333722 1 GO:0140767 enzyme-substrate adaptor activity 18/2948 139/18639 0.129496402877698 0.818752867448239 0.853174931997934 1 GO:0004181 metallocarboxypeptidase activity 3/2948 29/18639 0.103448275862069 0.654061198708651 0.859193528655596 1 GO:0004629 phospholipase C activity 3/2948 29/18639 0.103448275862069 0.654061198708651 0.859193528655596 1 GO:0051861 glycolipid binding 3/2948 29/18639 0.103448275862069 0.654061198708651 0.859193528655596 1 GO:0106222 lncRNA binding 3/2948 29/18639 0.103448275862069 0.654061198708651 0.859193528655596 1 GO:0046915 transition metal ion transmembrane transporter activity 5/2948 45/18639 0.111111111111111 0.702510176390773 0.860350067777599 1 GO:0141003 histone H2AX kinase activity 49/2948 354/18639 0.138418079096045 0.875160982452913 0.865534716284428 1 GO:0008373 sialyltransferase activity 2/2948 21/18639 0.0952380952380952 0.60215157976352 0.867102833090176 1 GO:0042626 ATPase-coupled transmembrane transporter activity 12/2948 98/18639 0.122448979591837 0.774194888267383 0.868671831395668 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/2948 46/18639 0.108695652173913 0.687238216034452 0.873026315025625 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0003720 telomerase activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0004032 aldose reductase (NADPH) activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0005247 voltage-gated chloride channel activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0005436 sodium:phosphate symporter activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0008504 monoamine transmembrane transporter activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0015132 prostaglandin transmembrane transporter activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0017166 vinculin binding 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0034452 dynactin binding 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0035197 siRNA binding 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0035251 UDP-glucosyltransferase activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0070008 serine-type exopeptidase activity 1/2948 12/18639 0.0833333333333333 0.52688263229308 0.873396090870192 1 GO:0008237 metallopeptidase activity 24/2948 184/18639 0.130434782608696 0.824685859241343 0.874022804228489 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/2948 30/18639 0.1 0.632259158751696 0.874574207481966 1 GO:0031210 phosphatidylcholine binding 3/2948 30/18639 0.1 0.632259158751696 0.874574207481966 1 GO:0032452 histone demethylase activity 3/2948 30/18639 0.1 0.632259158751696 0.874574207481966 1 GO:0042578 phosphoric ester hydrolase activity 50/2948 363/18639 0.137741046831956 0.870880383955504 0.876031972315676 1 GO:0015179 L-amino acid transmembrane transporter activity 7/2948 62/18639 0.112903225806452 0.713840985687399 0.879130163670853 1 GO:0140996 histone H3 kinase activity 49/2948 357/18639 0.137254901960784 0.86780668848272 0.879606815915351 1 GO:0016782 transferase activity, transferring sulphur-containing groups 8/2948 70/18639 0.114285714285714 0.722581895716224 0.883133686465071 1 GO:0004407 histone deacetylase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0032931 histone H3K56 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0033558 protein lysine deacetylase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0043992 histone H3K9 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0043993 histone H3K18 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0043994 histone H3K23 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0043999 histone H2AK5 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044012 histone H2AK9 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044014 histone H2BK5 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044015 histone H2BK12 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044016 histone H3K4 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044017 histone H3K27 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0044018 histone H3K36 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0046972 histone H4K16 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0050321 tau-protein kinase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0061133 endopeptidase activator activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0140908 histone H3K122 acetyltransferase activity 2/2948 22/18639 0.0909090909090909 0.574781053410633 0.883889536966696 1 GO:0061749 forked DNA-dependent helicase activity 5/2948 47/18639 0.106382978723404 0.672616126331592 0.884712267488346 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/2948 47/18639 0.106382978723404 0.672616126331592 0.884712267488346 1 GO:0004674 protein serine/threonine kinase activity 60/2948 433/18639 0.138568129330254 0.876109688801426 0.885768915491112 1 GO:0101005 deubiquitinase activity 14/2948 115/18639 0.121739130434783 0.769706801958587 0.888399422890925 1 GO:0008327 methyl-CpG binding 3/2948 31/18639 0.0967741935483871 0.61186370201777 0.888445545839919 1 GO:0140457 protein demethylase activity 3/2948 31/18639 0.0967741935483871 0.61186370201777 0.888445545839919 1 GO:0004843 cysteine-type deubiquitinase activity 13/2948 108/18639 0.12037037037037 0.761052691090004 0.890522711994125 1 GO:0035173 histone kinase activity 49/2948 360/18639 0.136111111111111 0.860574966078697 0.892535470388706 1 GO:0003964 RNA-directed DNA polymerase activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0004465 lipoprotein lipase activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0004535 poly(A)-specific ribonuclease activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0008417 fucosyltransferase activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0030955 potassium ion binding 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0035673 oligopeptide transmembrane transporter activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0046975 histone H3K36 methyltransferase activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0071714 icosanoid transmembrane transporter activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0071837 HMG box domain binding 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0140666 annealing activity 1/2948 13/18639 0.0769230769230769 0.486353199039766 0.893433043901527 1 GO:0009378 four-way junction helicase activity 5/2948 48/18639 0.104166666666667 0.65860329036635 0.895463394622533 1 GO:0036121 double-stranded DNA helicase activity 5/2948 48/18639 0.104166666666667 0.65860329036635 0.895463394622533 1 GO:0038187 pattern recognition receptor activity 5/2948 48/18639 0.104166666666667 0.65860329036635 0.895463394622533 1 GO:0043138 3'-5' DNA helicase activity 5/2948 48/18639 0.104166666666667 0.65860329036635 0.895463394622533 1 GO:0050997 quaternary ammonium group binding 4/2948 40/18639 0.1 0.632259158751696 0.896524600591689 1 GO:0061791 GTPase motor activity 4/2948 40/18639 0.1 0.632259158751696 0.896524600591689 1 GO:1990606 membrane scission GTPase motor activity 4/2948 40/18639 0.1 0.632259158751696 0.896524600591689 1 GO:0004620 phospholipase activity 13/2948 109/18639 0.119266055045872 0.754070556309362 0.8976854771196 1 GO:0004536 DNA nuclease activity 7/2948 64/18639 0.109375 0.691533454884668 0.898211261181469 1 GO:0005158 insulin receptor binding 2/2948 23/18639 0.0869565217391304 0.549790572827562 0.898692744485367 1 GO:0016917 GABA receptor activity 2/2948 23/18639 0.0869565217391304 0.549790572827562 0.898692744485367 1 GO:0015079 potassium ion transmembrane transporter activity 20/2948 160/18639 0.125 0.79032394843962 0.899867138315087 1 GO:0005267 potassium channel activity 15/2948 124/18639 0.120967741935484 0.764829627522213 0.900189750849701 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2948 57/18639 0.105263157894737 0.665535956580733 0.90546780106243 1 GO:0016757 glycosyltransferase activity 35/2948 267/18639 0.131086142322097 0.828804140685744 0.906728784391732 1 GO:0004705 JUN kinase activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0008559 ABC-type xenobiotic transporter activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0015386 potassium:proton antiporter activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0015926 glucosidase activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0019763 immunoglobulin receptor activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0046030 inositol trisphosphate phosphatase activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0061783 peptidoglycan muralytic activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0070742 C2H2 zinc finger domain binding 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:1901474 azole transmembrane transporter activity 1/2948 14/18639 0.0714285714285714 0.45161368482264 0.910299756377544 1 GO:0015295 solute:proton symporter activity 2/2948 24/18639 0.0833333333333333 0.52688263229308 0.911719720356084 1 GO:0043998 histone H2A acetyltransferase activity 2/2948 24/18639 0.0833333333333333 0.52688263229308 0.911719720356084 1 GO:0070840 dynein complex binding 2/2948 24/18639 0.0833333333333333 0.52688263229308 0.911719720356084 1 GO:0140612 DNA damage sensor activity 2/2948 24/18639 0.0833333333333333 0.52688263229308 0.911719720356084 1 GO:0061980 regulatory RNA binding 6/2948 58/18639 0.103448275862069 0.654061198708651 0.913940127501295 1 GO:0048029 monosaccharide binding 8/2948 74/18639 0.108108108108108 0.683523414866698 0.916149239044396 1 GO:0043175 RNA polymerase core enzyme binding 4/2948 42/18639 0.0952380952380952 0.60215157976352 0.916708930244774 1 GO:0008173 RNA methyltransferase activity 7/2948 67/18639 0.104477611940299 0.660569270337593 0.922003000337408 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/2948 34/18639 0.0882352941176471 0.55787572831032 0.92217390450301 1 GO:0051427 hormone receptor binding 3/2948 34/18639 0.0882352941176471 0.55787572831032 0.92217390450301 1 GO:0000030 mannosyltransferase activity 2/2948 25/18639 0.08 0.505807327001357 0.923161807588302 1 GO:0017056 structural constituent of nuclear pore 2/2948 25/18639 0.08 0.505807327001357 0.923161807588302 1 GO:0042974 nuclear retinoic acid receptor binding 2/2948 25/18639 0.08 0.505807327001357 0.923161807588302 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/2948 25/18639 0.08 0.505807327001357 0.923161807588302 1 GO:0016887 ATP hydrolysis activity 56/2948 417/18639 0.134292565947242 0.8490770477241 0.92443786697043 1 GO:0004559 alpha-mannosidase activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0015116 sulfate transmembrane transporter activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0017081 chloride channel regulator activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0030553 cGMP binding 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0033130 acetylcholine receptor binding 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0034483 heparan sulfate sulfotransferase activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0042809 nuclear vitamin D receptor binding 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0050780 dopamine receptor binding 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0061578 K63-linked deubiquitinase activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0141050 histone H3K deacetylase activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0141051 histone H4K deacetylase activity 1/2948 15/18639 0.0666666666666667 0.421506105834464 0.924497679502323 1 GO:0004497 monooxygenase activity 12/2948 106/18639 0.113207547169811 0.715765085379279 0.925353138987649 1 GO:0035591 signaling adaptor activity 15/2948 129/18639 0.116279069767442 0.735185068315926 0.928383300588274 1 GO:0004435 phosphatidylinositol phospholipase C activity 2/2948 26/18639 0.0769230769230769 0.486353199039766 0.93319427770233 1 GO:0008066 glutamate receptor activity 2/2948 26/18639 0.0769230769230769 0.486353199039766 0.93319427770233 1 GO:0019905 syntaxin binding 6/2948 61/18639 0.0983606557377049 0.621894254509865 0.935508648781122 1 GO:0003688 DNA replication origin binding 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0004707 MAP kinase activity 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0022841 potassium ion leak channel activity 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0022858 alanine transmembrane transporter activity 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0030275 LRR domain binding 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2948 16/18639 0.0625 0.39516197421981 0.936448970354296 1 GO:0008146 sulfotransferase activity 5/2948 53/18639 0.0943396226415094 0.596470904482732 0.937113031743842 1 GO:0016758 hexosyltransferase activity 24/2948 197/18639 0.121827411167513 0.770264964976686 0.937679349737415 1 GO:0000993 RNA polymerase II complex binding 3/2948 36/18639 0.0833333333333333 0.52688263229308 0.939170086568981 1 GO:0004033 aldo-keto reductase (NADPH) activity 3/2948 36/18639 0.0833333333333333 0.52688263229308 0.939170086568981 1 GO:0004190 aspartic-type endopeptidase activity 3/2948 36/18639 0.0833333333333333 0.52688263229308 0.939170086568981 1 GO:0005385 zinc ion transmembrane transporter activity 2/2948 27/18639 0.0740740740740741 0.468340117593849 0.941976626471874 1 GO:0008395 steroid hydroxylase activity 2/2948 27/18639 0.0740740740740741 0.468340117593849 0.941976626471874 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/2948 27/18639 0.0740740740740741 0.468340117593849 0.941976626471874 1 GO:0005261 monoatomic cation channel activity 44/2948 341/18639 0.129032258064516 0.815818269357027 0.944029245408622 1 GO:0042805 actinin binding 3/2948 37/18639 0.0810810810810811 0.512642561150024 0.946314314841961 1 GO:0070001 aspartic-type peptidase activity 3/2948 37/18639 0.0810810810810811 0.512642561150024 0.946314314841961 1 GO:0004659 prenyltransferase activity 1/2948 17/18639 0.0588235294117647 0.37191715220688 0.946509027025914 1 GO:0009881 photoreceptor activity 1/2948 17/18639 0.0588235294117647 0.37191715220688 0.946509027025914 1 GO:0017110 nucleoside diphosphate phosphatase activity 1/2948 17/18639 0.0588235294117647 0.37191715220688 0.946509027025914 1 GO:0045125 bioactive lipid receptor activity 1/2948 17/18639 0.0588235294117647 0.37191715220688 0.946509027025914 1 GO:0005253 monoatomic anion channel activity 11/2948 103/18639 0.106796116504854 0.675228227793073 0.947819200382424 1 GO:0005242 inward rectifier potassium channel activity 2/2948 28/18639 0.0714285714285714 0.45161368482264 0.949653178091258 1 GO:0050698 proteoglycan sulfotransferase activity 2/2948 28/18639 0.0714285714285714 0.45161368482264 0.949653178091258 1 GO:0140359 ABC-type transporter activity 4/2948 47/18639 0.0851063829787234 0.538092901065273 0.952607972542288 1 GO:0042887 amide transmembrane transporter activity 3/2948 38/18639 0.0789473684210526 0.49915196743555 0.952671105565833 1 GO:0004970 glutamate-gated receptor activity 1/2948 18/18639 0.0555555555555556 0.351255088195387 0.954977042723884 1 GO:0015280 ligand-gated sodium channel activity 1/2948 18/18639 0.0555555555555556 0.351255088195387 0.954977042723884 1 GO:0022851 GABA-gated chloride ion channel activity 1/2948 18/18639 0.0555555555555556 0.351255088195387 0.954977042723884 1 GO:0099094 ligand-gated monoatomic cation channel activity 15/2948 136/18639 0.110294117647059 0.6973446603879 0.956337681052071 1 GO:0106310 protein serine kinase activity 46/2948 361/18639 0.127423822714681 0.805648789545098 0.957510785591445 1 GO:0000149 SNARE binding 11/2948 106/18639 0.10377358490566 0.656117994931005 0.959145559848583 1 GO:0016298 lipase activity 14/2948 130/18639 0.107692307692308 0.680894478655673 0.961375558719807 1 GO:0003756 protein disulfide isomerase activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0004890 GABA-A receptor activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0022821 solute:potassium antiporter activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0031420 alkali metal ion binding 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0034987 immunoglobulin receptor binding 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0046527 glucosyltransferase activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0046624 sphingolipid transporter activity 1/2948 19/18639 0.0526315789473684 0.332767978290366 0.962104891821676 1 GO:0017116 single-stranded DNA helicase activity 5/2948 58/18639 0.0862068965517241 0.545050998923876 0.963209101942019 1 GO:0005184 neuropeptide hormone activity 2/2948 31/18639 0.0645161290322581 0.407909134678514 0.967281488833564 1 GO:0072349 modified amino acid transmembrane transporter activity 2/2948 31/18639 0.0645161290322581 0.407909134678514 0.967281488833564 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/2948 20/18639 0.05 0.316129579375848 0.968104611419405 1 GO:0042288 MHC class I protein binding 1/2948 20/18639 0.05 0.316129579375848 0.968104611419405 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/2948 20/18639 0.05 0.316129579375848 0.968104611419405 1 GO:0140939 histone H4 methyltransferase activity 1/2948 20/18639 0.05 0.316129579375848 0.968104611419405 1 GO:0003724 RNA helicase activity 7/2948 77/18639 0.0909090909090909 0.574781053410633 0.969932042367442 1 GO:0004520 DNA endonuclease activity 3/2948 42/18639 0.0714285714285714 0.45161368482264 0.971695584781538 1 GO:0015106 bicarbonate transmembrane transporter activity 2/2948 32/18639 0.0625 0.39516197421981 0.971705136508996 1 GO:0160041 neuropeptide activity 2/2948 32/18639 0.0625 0.39516197421981 0.971705136508996 1 GO:0046943 carboxylic acid transmembrane transporter activity 21/2948 188/18639 0.111702127659574 0.706246932648171 0.972629679463568 1 GO:0005248 voltage-gated sodium channel activity 1/2948 21/18639 0.0476190476190476 0.30107578988176 0.973154700335866 1 GO:0015125 bile acid transmembrane transporter activity 1/2948 21/18639 0.0476190476190476 0.30107578988176 0.973154700335866 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 4/2948 52/18639 0.0769230769230769 0.486353199039766 0.973739197053988 1 GO:0015297 antiporter activity 14/2948 135/18639 0.103703703703704 0.655676164631388 0.973823956952505 1 GO:0005342 organic acid transmembrane transporter activity 21/2948 189/18639 0.111111111111111 0.702510176390773 0.974433960114049 1 GO:0005245 voltage-gated calcium channel activity 3/2948 43/18639 0.0697674418604651 0.441111040989555 0.975166512015001 1 GO:0008186 ATP-dependent activity, acting on RNA 7/2948 79/18639 0.0886075949367089 0.560229634336946 0.975419197974955 1 GO:0033038 bitter taste receptor activity 1/2948 22/18639 0.0454545454545455 0.287390526705316 0.977405422401065 1 GO:0090482 vitamin transmembrane transporter activity 2/2948 34/18639 0.0588235294117647 0.37191715220688 0.978884416788664 1 GO:1901682 sulfur compound transmembrane transporter activity 5/2948 63/18639 0.0793650793650794 0.501792983136267 0.978987712007743 1 GO:0003887 DNA-directed DNA polymerase activity 1/2948 23/18639 0.0434782608695652 0.274895286413781 0.980983271397233 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/2948 23/18639 0.0434782608695652 0.274895286413781 0.980983271397233 1 GO:0005283 amino acid:sodium symporter activity 1/2948 23/18639 0.0434782608695652 0.274895286413781 0.980983271397233 1 GO:0016493 C-C chemokine receptor activity 1/2948 23/18639 0.0434782608695652 0.274895286413781 0.980983271397233 1 GO:0031681 G-protein beta-subunit binding 1/2948 23/18639 0.0434782608695652 0.274895286413781 0.980983271397233 1 GO:0034061 DNA polymerase activity 2/2948 35/18639 0.0571428571428571 0.361290947858112 0.981777187262164 1 GO:0140713 histone chaperone activity 17/2948 164/18639 0.103658536585366 0.655390591388953 0.983065699007686 1 GO:0019957 C-C chemokine binding 1/2948 24/18639 0.0416666666666667 0.26344131614654 0.983994730138152 1 GO:0008509 monoatomic anion transmembrane transporter activity 15/2948 149/18639 0.100671140939597 0.636502508810432 0.984000556886007 1 GO:0140658 ATP-dependent chromatin remodeler activity 16/2948 158/18639 0.10126582278481 0.640262439242224 0.985351870073664 1 GO:0099095 ligand-gated monoatomic anion channel activity 3/2948 47/18639 0.0638297872340425 0.403569675798955 0.985404144565257 1 GO:0005216 monoatomic ion channel activity 55/2948 448/18639 0.122767857142857 0.776211020788913 0.986161505910361 1 GO:0000510 H3-H4 histone complex chaperone activity 15/2948 151/18639 0.0993377483443709 0.628072012004996 0.986413475183974 1 GO:0140584 chromatin extrusion motor activity 15/2948 151/18639 0.0993377483443709 0.628072012004996 0.986413475183974 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 15/2948 151/18639 0.0993377483443709 0.628072012004996 0.986413475183974 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 15/2948 151/18639 0.0993377483443709 0.628072012004996 0.986413475183974 1 GO:0005251 delayed rectifier potassium channel activity 1/2948 25/18639 0.04 0.252903663500678 0.986529435244396 1 GO:0005537 D-mannose binding 1/2948 25/18639 0.04 0.252903663500678 0.986529435244396 1 GO:0015271 outward rectifier potassium channel activity 1/2948 25/18639 0.04 0.252903663500678 0.986529435244396 1 GO:0008188 neuropeptide receptor activity 3/2948 48/18639 0.0625 0.39516197421981 0.987244225258183 1 GO:0015616 DNA translocase activity 15/2948 152/18639 0.0986842105263158 0.623939959294437 0.987490471610458 1 GO:0140674 ATP-dependent histone chaperone activity 15/2948 152/18639 0.0986842105263158 0.623939959294437 0.987490471610458 1 GO:0061775 cohesin loader activity 15/2948 153/18639 0.0980392156862745 0.6198619203448 0.988488526478417 1 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2948 26/18639 0.0384615384615385 0.243176599519883 0.988662841546079 1 GO:0004950 chemokine receptor activity 1/2948 26/18639 0.0384615384615385 0.243176599519883 0.988662841546079 1 GO:0015108 chloride transmembrane transporter activity 11/2948 121/18639 0.0909090909090909 0.574781053410633 0.989101369043543 1 GO:0035402 histone H3T11 kinase activity 27/2948 247/18639 0.109311740890688 0.691133493372299 0.989167841524028 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 59/2948 484/18639 0.121900826446281 0.770729139800621 0.990443715600876 1 GO:0005104 fibroblast growth factor receptor binding 1/2948 27/18639 0.037037037037037 0.234170058796924 0.990458465202779 1 GO:0015144 carbohydrate transmembrane transporter activity 2/2948 40/18639 0.05 0.316129579375848 0.991353381088961 1 GO:0030331 nuclear estrogen receptor binding 2/2948 40/18639 0.05 0.316129579375848 0.991353381088961 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 26/2948 243/18639 0.106995884773663 0.676491280968893 0.991561942048993 1 GO:0015103 inorganic anion transmembrane transporter activity 16/2948 165/18639 0.096969696969697 0.613099790304675 0.991739076771367 1 GO:0008527 taste receptor activity 1/2948 28/18639 0.0357142857142857 0.22580684241132 0.991969772132835 1 GO:0003823 antigen binding 17/2948 174/18639 0.0977011494252874 0.617724465447059 0.992379891404105 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0004711 ribosomal protein S6 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0035175 histone H3S10 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0035979 histone H2AXS139 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0044022 histone H3S28 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0044023 histone H4S1 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0044024 histone H2AS1 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0044025 histone H2BS14 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0072354 histone H3T3 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0072371 histone H2AS121 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0140823 histone H2BS36 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0140855 histone H3S57 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0140995 histone H2A kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0140997 histone H4 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0140998 histone H2B kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:1990244 histone H2AT120 kinase activity 26/2948 245/18639 0.106122448979592 0.670968903165065 0.992673727316358 1 GO:0004677 DNA-dependent protein kinase activity 26/2948 246/18639 0.105691056910569 0.668241387298541 0.993177559960867 1 GO:0140857 histone H3T45 kinase activity 26/2948 246/18639 0.105691056910569 0.668241387298541 0.993177559960867 1 GO:0005416 amino acid:monoatomic cation symporter activity 1/2948 29/18639 0.0344827586206897 0.21802039956955 0.993241767820998 1 GO:0001216 DNA-binding transcription activator activity 59/2948 491/18639 0.120162932790224 0.759741147990836 0.993337293011124 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/2948 53/18639 0.0566037735849057 0.357882542689639 0.993562347278486 1 GO:0035403 histone H3T6 kinase activity 26/2948 247/18639 0.105263157894737 0.665535956580733 0.993649291541672 1 GO:0003689 DNA clamp loader activity 15/2948 160/18639 0.09375 0.592742961329715 0.993664434270982 1 GO:0005254 chloride channel activity 6/2948 83/18639 0.072289156626506 0.457054813555443 0.993965867788257 1 GO:0004679 AMP-activated protein kinase activity 26/2948 248/18639 0.104838709677419 0.662852343852585 0.994090760616087 1 GO:0003678 DNA helicase activity 5/2948 74/18639 0.0675675675675676 0.427202134291687 0.994287223572321 1 GO:0001653 peptide receptor activity 11/2948 128/18639 0.0859375 0.543347714552239 0.994401655858916 1 GO:0015171 amino acid transmembrane transporter activity 8/2948 102/18639 0.0784313725490196 0.49588953627584 0.994477457497806 1 GO:0005452 solute:inorganic anion antiporter activity 1/2948 31/18639 0.032258064516129 0.203954567339257 0.995213363941956 1 GO:0008528 G protein-coupled peptide receptor activity 10/2948 122/18639 0.0819672131147541 0.518245212091554 0.995685651011226 1 GO:0005244 voltage-gated monoatomic ion channel activity 16/2948 173/18639 0.092485549132948 0.584748354914863 0.995837599056923 1 GO:0042910 xenobiotic transmembrane transporter activity 1/2948 32/18639 0.03125 0.197580987109905 0.995971693859148 1 GO:0022832 voltage-gated channel activity 16/2948 175/18639 0.0914285714285714 0.578065516572979 0.996510083044966 1 GO:0042923 neuropeptide binding 1/2948 33/18639 0.0303030303030303 0.191593684470211 0.996609918532832 1 GO:0015291 secondary active transmembrane transporter activity 30/2948 287/18639 0.104529616724739 0.660898075350205 0.996695347397741 1 GO:0005249 voltage-gated potassium channel activity 7/2948 98/18639 0.0714285714285714 0.45161368482264 0.99686672887451 1 GO:0015020 glucuronosyltransferase activity 1/2948 34/18639 0.0294117647058824 0.18595857610344 0.997147054949322 1 GO:0005343 organic acid:sodium symporter activity 1/2948 35/18639 0.0285714285714286 0.180645473929056 0.997599109881297 1 GO:0140299 molecular sensor activity 4/2948 71/18639 0.0563380281690141 0.356202342958702 0.997669666418901 1 GO:0004386 helicase activity 13/2948 155/18639 0.0838709677419355 0.530281875082068 0.997855487789765 1 GO:0015081 sodium ion transmembrane transporter activity 14/2948 164/18639 0.0853658536585366 0.539733428202667 0.997945037029435 1 GO:0140097 catalytic activity, acting on DNA 35/2948 336/18639 0.104166666666667 0.65860329036635 0.99841935855533 1 GO:0008094 ATP-dependent activity, acting on DNA 19/2948 210/18639 0.0904761904761905 0.572044000775344 0.998582032137715 1 GO:0015276 ligand-gated monoatomic ion channel activity 16/2948 186/18639 0.0860215053763441 0.543878846238018 0.998718137083582 1 GO:0008514 organic anion transmembrane transporter activity 26/2948 269/18639 0.0966542750929368 0.611105506600152 0.998807618706349 1 GO:0015294 solute:monoatomic cation symporter activity 8/2948 116/18639 0.0689655172413793 0.436040799139101 0.99883509521422 1 GO:0022834 ligand-gated channel activity 16/2948 188/18639 0.0851063829787234 0.538092901065273 0.998937524228045 1 GO:0046873 metal ion transmembrane transporter activity 49/2948 450/18639 0.108888888888889 0.688459972862958 0.999020604743503 1 GO:0015370 solute:sodium symporter activity 4/2948 79/18639 0.0506329113924051 0.320131219621112 0.999210562196676 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/2948 56/18639 0.0357142857142857 0.22580684241132 0.999260560343299 1 GO:0003730 mRNA 3'-UTR binding 24/2948 262/18639 0.0916030534351145 0.579168695039722 0.999443473818391 1 GO:0005179 hormone activity 9/2948 132/18639 0.0681818181818182 0.431085790057975 0.999451027764071 1 GO:0022843 voltage-gated monoatomic cation channel activity 10/2948 143/18639 0.0699300699300699 0.442139271854333 0.999542959406198 1 GO:0015293 symporter activity 10/2948 146/18639 0.0684931506849315 0.433054218323079 0.999673727253471 1 GO:0030594 neurotransmitter receptor activity 5/2948 97/18639 0.0515463917525773 0.325906782861699 0.999701883337599 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/2948 63/18639 0.0317460317460317 0.200717193254507 0.999754064437285 1 GO:0022835 transmitter-gated channel activity 2/2948 63/18639 0.0317460317460317 0.200717193254507 0.999754064437285 1 GO:0022836 gated channel activity 29/2948 318/18639 0.0911949685534591 0.576588540999974 0.999843950530712 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2948 53/18639 0.0188679245283019 0.119294180896546 0.999892591176856 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/2948 69/18639 0.0289855072463768 0.183263524275854 0.999905117845465 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/2948 73/18639 0.0273972602739726 0.173221687329232 0.999949911993704 1 GO:0045182 translation regulator activity 18/2948 356/18639 0.050561797752809 0.319681597121644 0.999999999951553 1 GO:0030371 translation repressor activity 11/2948 329/18639 0.033434650455927 0.211393639704214 0.999999999999959 1 GO:0004984 olfactory receptor activity 4/2948 419/18639 0.00954653937947494 0.0603588695705676 1 1