category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	66/507	222/9376	5.49794765179381	RPL39/RPL37/RPL12/RPL41/RPL28/RPL34/RPL30/RPLP1/RPS28/RPS21/RPS27/RPS15A/FAU/RPS23/RPL10/RPL21/RPS4X/RPS12/RPL35A/UBA52/RPL37A/RPS13/RPS19/RPS11/RPS29/RPL36/RPL22/RPS27A/RPL14/RPS24/RPLP2/RPL13/RPL24/RPL11/RPS27L/RPS3/RPL26/RPL32/RPL7/RPS14/RPS5/MRPL33/RSL24D1/RPSA/RPL38/RPS3A/RPS7/RPS20/RPL22L1/RPL15/RPL27A/RPLP0/RPL13A/RPL18/RPL19/RPS8/RPL18A/RPL36AL/RPS16/RPS15/RPL9/RPL23A/RPS25/MRPL52/RPL6/RPL8	16.2157753948506
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	68/507	238/9376	5.28374189912651	RPL39/RPL37/RPL12/RPL41/RPL28/RPL34/RPL30/RPLP1/RPS28/RPS21/RPS27/RPS15A/FAU/RPS23/RPL10/RPL21/RPS4X/RPS12/RPL35A/UBA52/RPL37A/RPS13/RPS19/RPS11/RPS29/RPL36/SELP/RPL22/RPS27A/RPL14/RPS24/RPLP2/RPL13/RPL24/RPL11/RPS27L/RPS3/RPL26/RPL32/RPL7/RPS14/RPS5/RSL24D1/RPSA/RPL38/RPS3A/MMP1/RPS7/RPS20/RPL22L1/RPL15/RPL27A/RPLP0/RPL13A/CXCL8/RPL18/RPL19/RPS8/RPL18A/PRKCA/RPL36AL/RPS16/RPS15/RPL9/RPL23A/RPS25/RPL6/RPL8	16.0043665028407
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	29/507	138/9376	3.88623045479233	ATP5F1E/NDUFA4/COX7C/MT-ND3/NDUFB1/COX6C/NDUFS5/ATP5ME/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/ATP6V1G1/NDUFA1/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/NDUFB2/NDUFA2/COX7B/ATP6V0E1/NDUFA3	8.16646038381628
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	39/507	268/9376	2.69115958668197	ATP5F1E/TXN/TH/UBA52/NDUFA4/SNCA/COX7C/MT-ND3/SOD1/NDUFB1/RPS27A/KLC3/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/PSMD9/TUBA4A/DDIT3/NDUFB2/NDUFA2/COX7B/SEM1/UCHL1/HSPA5/NDUFA3	6.7157229007703
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/507	205/9376	2.886727281474	ATP5F1E/NDUFA4/RAC2/COX7C/MT-ND3/NDUFB1/GAPDH/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/TGFB2/PPP1CB/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/PRKCA/ATP5PD/NDUFB2/NDUFA2/COX7B/MMP2/NDUFA3	6.53025294150179
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	40/507	308/9376	2.40170086323932	ATP5F1E/NDUFA4/SOD2/COX7C/MT-ND3/SOD1/NDUFB1/POLR2L/KLC3/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/UQCRB/UQCRH/COX8A/AP2S1/CLTB/ATP5MC2/NDUFC1/COX4I1/ATP5PD/PSMD9/TAF4B/TUBA4A/NDUFB2/NDUFA2/COX7B/SEM1/CREB5/DCTN3/POLR2I/POLR2G/NDUFA3	5.98035870177571
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/507	157/9376	3.06255103707333	NDUFA4/COX7C/NDUFB1/COX6C/NDUFS5/COX6B1/LEPR/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/CXCL8/UQCRB/UQCRH/COX8A/NDUFC1/COX4I1/DDIT3/NDUFB2/NDUFA2/COX7B/IRS2/NDUFA3	6.23110275257734
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	32/507	227/9376	2.60695635551617	ATP5F1E/NDUFA4/SOD2/COX7C/MT-ND3/SOD1/NDUFB1/HIF1A/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/GSTT2B/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/MGST1/NDUFB2/NDUFA2/COX7B/PRKD1/NDUFA3	5.85979586309201
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	36/507	275/9376	2.42091447014524	ATP5F1E/NDUFA4/RAC2/COX7C/MT-ND3/SOD1/NDUFB1/KLC3/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/HSPA1B/NDUFA1/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/PSMD9/TUBA4A/DDIT3/NDUFB2/NDUFA2/COX7B/SEM1/HSPA5/CREB5/NDUFA3	5.71797190507519
NA	NA	hsa04382	Cornified envelope formation	29/507	217/9376	2.47142766249466	S100A6/KRT6A/KRT24/SPRR3/S100A8/KRT5/S100A4/KRT17/KRT14/S100A10/DSG1/PPL/EVPL/S100A14/LAMB3/S100A9/KRT10/KRT16/S100A12/S100A11/CLDN1/PPP2R5C/PKP1/LAMA3/DSG2/S100A3/PKP3/LAMC2/KRT18	5.2432074877721
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	30/507	235/9376	2.36082084854589	ATP5F1E/NDUFA4/COX7C/MT-ND3/ACTB/NDUFB1/NDUFAF8/COX6C/NDUFS5/ATP5ME/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/NDUFB2/NDUFA2/COX7B/CREB5/NDUFA3	5.05115064867004
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	39/507	368/9376	1.95986622073579	ATP5F1E/NDUFA4/COX7C/MT-ND3/ACTB/SOD1/NDUFB1/KLC3/COX6C/NDUFS5/COX6B1/MAP1LC3B/PFN2/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/ATP5PD/PSMD9/TUBA4A/DDIT3/NDUFB2/NDUFA2/COX7B/SEM1/HNRNPA1/SQSTM1/HSPA5/DCTN3/NDUFA3	4.49130676681583
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/507	87/9376	3.18846493912807	COX7C/ASPH/COX6C/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/CACNA2D1/UQCRB/UQCRH/COX8A/COX4I1/COX7B	4.90305797590588
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	40/507	388/9376	1.90650480896318	ATP5F1E/NDUFA4/WNT5A/SNCA/COX7C/DKK1/MT-ND3/BACE2/NDUFB1/KLC3/GAPDH/COX6C/NDUFS5/COX6B1/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/PTGS2/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/WNT2/ATP5PD/PSMD9/TUBA4A/DDIT3/NDUFB2/NDUFA2/COX7B/SEM1/IRS2/MME/NDUFA3	4.36020324396633
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	28/507	248/9376	2.08793026659032	S100A10/TXN/AHNAK2/ANXA2/ACTB/KLC3/FLNA/MYL12A/PTPRC/RPS3/GAPDH/DYNLT3/DYNLL1/PFN2/MYL9/CXCL8/RAB9A/MYL12B/TUBA4A/BIRC3/CYFIP2/ARPC3/TCF7/DYNLT1/BRK1/DCTN3/LEF1/RHOH	4.15136934725404
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	45/507	480/9376	1.73372781065089	ATP5F1E/UBA52/NDUFA4/WNT5A/SNCA/COX7C/DKK1/MT-ND3/SOD1/NDUFB1/RPS27A/KLC3/COX6C/NDUFS5/COX6B1/MAP1LC3B/MT-CO2/UQCR11/UQCRQ/COX7A2/COX7A1/NDUFB4/NDUFA1/PTGS2/UQCRB/UQCRH/COX8A/ATP5MC2/NDUFC1/COX4I1/WNT2/PRKCA/ATP5PD/PSMD9/TUBA4A/DDIT3/NDUFB2/NDUFA2/COX7B/SEM1/UCHL1/SQSTM1/HSPA5/DCTN3/NDUFA3	3.94557681148707
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/507	232/9376	1.99279058695504	TMSB4X/ACTN1/RAC2/MYH14/ACTB/MYL12A/RGCC/PDGFD/TIAM1/ITGB6/PFN2/MYL9/ITGA4/PPP1CB/MYL12B/RRAS2/CXCR4/ENAH/ITGAX/CYFIP2/PDGFRA/ARPC3/GSN/F2R/BRK1	3.66088279509781
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/507	50/9376	3.3287573964497	THBS1/HBA2/HBA1/VCAM1/SELP/KLRB1/CXCL8/TGFB2/SELE	3.94742451853505
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/507	116/9376	2.39134870434605	ACTN1/VCAM1/RAC2/ACTB/MYL12A/CLDN1/ITK/MYL9/ITGA4/MYL12B/CXCR4/RAPGEF4/PRKCA/MMP2/RHOH	3.60505404344292
NA	NA	hsa04518	Integrin signaling	18/507	154/9376	2.16153077691539	THBS1/ACTN1/VCAM1/RAC2/LAMB3/CCND2/ACTB/FLNA/PDGFD/ITGB6/LIMS1/ITGA4/TNC/LAMA3/LAMB1/ITGAX/PDGFRA/LAMC2	3.47480800728043
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/507	100/9376	2.40410256410256	CD9/CD55/CD7/CD59/CD37/CD3G/IL7R/CD2/CD3D/CD3E/ITGA4/MME/HLA-DRB5	3.37497649759134
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/507	203/9376	1.91307896347684	THBS1/ACTN1/RAC2/LAMB3/CCND2/ACTB/FLNA/MYL12A/PDGFD/ITGB6/MYL9/ITGA4/PPP1CB/TNC/MYL12B/LAMA3/PRKCA/LAMB1/BIRC3/PDGFRA/LAMC2	3.14450977969549
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/507	160/9376	1.96489151873767	ALCAM/VCAM1/VCAN/SELP/PTPRC/SELL/CD2/CLDN1/SLITRK6/CDH2/ITGA4/SPN/SDC4/NRXN3/SELE/NEGR1/HLA-DRB5	2.94319839327564
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/507	149/9376	1.9858358815509	NDUFA4/MT-ND3/NDUFB1/NDUFS5/NDUFB4/NDUFA1/PTGS2/GNG5/GNB5/GABRG2/NDUFC1/PRKCA/NDUFB2/NDUFA2/GNG2/NDUFA3	2.90014549013235
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/507	174/9376	1.80679679883924	CRYAB/SSR4/KRTCAP2/FBXO2/HSPA1B/TXNDC5/RBX1/SEC61B/CALR/OSTC/DDIT3/TMEM258/DAD1/STUB1/HSPA5/ERP29/SELENOS	2.56832492471885
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/507	204/9376	1.72239625633291	THBS1/LUM/DCN/WNT5A/ACTB/FLNA/HIF1A/HOXD10/TIAM1/SDC4/TGFB2/PPP1CB/RRAS2/ANK3/WNT2/PRKCA/DDX5/PDCD4/MMP2	2.49408263019711
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/507	88/9376	2.10148825533441	SERPINB2/CD55/PROCR/CD59/F3/SERPINE2/PLAT/ITGAX/F2R/SERPINA1	2.48206067588457
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/507	157/9376	1.76685636754231	CCN2/WNT5A/AREG/CCND2/BMP2/ACTB/SMAD1/TGFB2/PPP1CB/WNT2/PATJ/BIRC3/TCF7/LEF1/YWHAZ	2.31672367700758
NA	NA	hsa04519	Cadherin signaling	31/507	404/9376	1.41902474271096	KRT6A/KRT24/KRT5/KRT17/KRT14/ACTN1/DSG1/RAC2/WNT5A/ACTB/KRT10/KRT16/DSC3/CDH2/MYO1D/PKP1/PPP1CB/GABRG2/DSG2/RRAS2/WNT2/ENAH/CYFIP2/PDGFRA/ARPC3/TCF7/BRK1/PKP3/LEF1/YWHAZ/KRT18	2.05843903322149
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/507	193/9376	1.62892561138874	RAC2/XCL2/TIAM1/ITK/XCL1/CXCL8/GNG5/CXCL14/GNB5/CXCR2/CX3CR1/CXCR4/CXCL11/CXCL2/GNG2/CCR7/PIK3R5	2.11075551845034
NA	NA	hsa04517	IgSF CAM signaling	24/507	299/9376	1.48439571748036	ACTN1/CD48/MYH14/ACTB/MBP/MYL12A/CD96/CD2/DYNLL1/SLITRK6/CDH2/MYL9/ITGA4/SLAMF1/MYL12B/ANK3/PRKCA/TUBA4A/ITGAX/PALS2/ARPC3/PLXNA4/LCK/SLIT2	2.03524647753461
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/507	99/9376	1.86798956029725	KRT24/KRT17/KRT14/DSG1/SELP/KRT10/KRT16/FCGR3B/HLA-DRB5/KRT18	2.07577659655981
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/507	86/9376	1.93532406770332	ACTB/ITGB6/CDH2/ITGA4/CACNA2D1/DSG2/SNTB1/TCF7/LEF1	2.08331897171468
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/507	100/9376	1.84930966469428	XCL2/XCL1/CXCL8/CXCL14/CXCR2/CX3CR1/CXCR4/CXCL11/CXCL2/CCR7	2.04144642336185
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/507	142/9376	1.69302997472012	TXN/VCAM1/RAC2/ACTB/GSTP1/PLAT/SUMO2/GSTT2B/SDC4/SELE/MGST1/SQSTM1/MMP2	1.98954399180449
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/507	37/9376	2.49906711445173	HBA2/HBA1/VCAM1/SELE/PRKCA	2.18435912792679
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/507	233/9376	1.50802075661765	THBS1/DCN/VCAN/MYH14/ACTB/ITGB6/NEBL/MYL9/COL5A2/ITGA4/SDC4/DSG2/ANK3/PDLIM3/FHL2/SNTB1/ENO1/PDLIM1/FMNL1	1.87744553980256
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/507	75/9376	1.9725969756739	THBS1/PERP/SFN/IGFBP3/CCND2/GADD45A/SESN3/SERPINB5	2.02185969430654
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/507	89/9376	1.87008842497174	THBS1/LAMB3/ITGB6/ITGA4/SDC4/TNC/LAMA3/LAMB1/LAMC2	1.97184585621357
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/507	38/9376	2.43330219038721	PTPRC/IL7R/CD3D/CD3E/LCK	2.1166785973903
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	7/507	63/9376	2.05478851632698	POLR2L/POLE4/RBX1/CETN2/GTF2H5/POLR2I/POLR2G	2.00836736910522
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/507	105/9376	1.76124729970884	VCAM1/TNFAIP3/GADD45A/CXCL8/PTGS2/CXCL2/BIRC3/CARD11/LCK/TRAF1	1.87546694669927
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/507	196/9376	1.50964054260758	CLEC2B/UBA52/ANGPT2/RPS27A/HIF1A/MAP1LC3B/CXCL8/PTGS2/GNG5/GNB5/CXCL2/GNG2/TCF7/PIK3R5/LEF1/ZFP36	1.72394320877502
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/507	212/9376	1.48293699527372	THBS1/RAC2/ANGPT2/ACTB/PDGFD/TIAM1/FYB1/PFN2/SKAP1/RAPGEF4/PRKCA/ENAH/PDGFRA/F2R/PRKD1/EFNA5/APBB1IP	1.70046679670942
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/507	94/9376	1.77061563640942	S100A8/JUND/TNFAIP3/S100A9/FOSL1/MMP1/CXCL8/PTGS2/CXCL2	1.79528437931419
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/507	201/9376	1.47208729527903	GZMB/IGFBP3/CCND2/GADD45A/SMAD1/PLAT/BCL11B/CXCL8/HMGA2/REL/LMO2/DDX5/DDIT3/BIRC3/SPINT1/TRAF1	1.61759425419557
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/507	31/9376	2.38620601896036	PFKP/TALDO1/TKT/PGM1	1.84829489808526
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/507	21/9376	2.64187094956326	DPYD/BCAT1/VNN2	1.8008563045498
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/507	103/9376	1.61590164876199	ACTN1/LAMB3/CXCL8/TGFB2/LAMA3/PRKCA/LAMB1/CXCL2/LAMC2	1.50269949193025
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/507	119/9376	1.55404173503721	VCAM1/TNFAIP3/IRF1/PTGS2/IL15/SELE/CXCL2/BIRC3/CREB5/TRAF1	1.45423006770615
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/507	75/9376	1.72602235371466	PFKP/GAPDH/PKM/TALDO1/TKT/ENO1/BCAT1	1.50927400645488
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/507	214/9376	1.38266143154713	RAC2/CD247/CD3G/CD3D/ELOB/CD3E/GNG5/RBX1/GNB5/CALR/APOBEC3A/CXCR4/PRKCA/RNF7/APOBEC3C/GNG2	1.35387548759843
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/507	106/9376	1.57016858323099	PDGFD/GSTP1/PLAT/PDGFRA/SPINT1/TCF7/CREB5/FOLH1/LEF1	1.41146021004244
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/507	362/9376	1.27714755849052	THBS1/ANGPT2/LAMB3/AREG/CCND2/PDGFD/ITGB6/IL7R/PPP2R5C/EREG/ITGA4/GNG5/TNC/GNB5/LAMA3/PRKCA/LAMB1/PDGFRA/GNG2/F2R/PIK3R5/EFNA5/CREB5/LAMC2/YWHAZ	1.28575687703615
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/507	184/9376	1.40708344052826	RHOD/RAC2/WNT5A/MYL12A/MYL9/MYL12B/SEMA4D/CXCR4/PRKCA/NGEF/ENAH/PLXNA4/EFNA5/SLIT2	1.33333607753092
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/507	63/9376	1.76124729970884	WNT5A/BMP2/GADD45A/WNT2/TCF7/LEF1	1.44945096850178
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/507	93/9376	1.59080401264024	ACTN1/RAC2/ACTB/MYL12A/MYL9/MYL12B/TCF7/LEF1	1.36896714661867
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/507	93/9376	1.59080401264024	RUNX3/CD247/STAT4/CD3G/CD3D/CD3E/LCK/HLA-DRB5	1.36896714661867
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/507	93/9376	1.59080401264024	LAMB3/GADD45A/PTGS2/LAMA3/LAMB1/BIRC3/LAMC2/TRAF1	1.36896714661867
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/507	155/9376	1.43172361137622	THBS1/ACTB/CTSS/FCGR3B/ATP6V1G1/CORO1A/SEC61B/CALR/TUBA4A/ATP6V0E1/MRC2/HLA-DRB5	1.29579091221329
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/507	51/9376	1.81304869087675	ACTB/ATP6V1G1/SEC61B/PRKCA/ATP6V0E1	1.39196883885613
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/507	110/9376	1.51307154384077	ANGPT2/HIF1A/PFKP/TIMP1/GAPDH/ELOB/RBX1/PRKCA/ENO1	1.29413747474328
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/507	95/9376	1.55731340184781	MMP1/ATP6V1G1/CXCL8/IL15/TGFB2/CXCL2/ATP6V0E1/HLA-DRB5	1.30531759913495
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/507	142/9376	1.43256382476317	UBA52/RPS27A/FBXO2/UBE2E2/ELOB/RBX1/RNF7/BIRC3/UBE2QL1/STUB1/UBE2B	1.2418001962716
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/507	38/9376	1.94664175230977	BST1/NT5E/NAMPT/NNMT	1.39798595854292
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/507	112/9376	1.48605240912933	LAMB3/HSPA1B/TGFB2/LAMA3/LAMB1/BIRC3/PIK3R5/LAMC2/HLA-DRB5	1.23721486289209
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/507	82/9376	1.57867898205609	DPYD/NME3/NME2/GSTP1/CDA/GSTT2B/MGST1	1.25833301497761
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/507	70/9376	1.58512256973795	CD55/RAC2/ACTB/PRF1/SNTB1/HLA-DRB5	1.1748073004996
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/507	41/9376	1.80420455092125	THBS1/MMP1/CXCL8/MMP2	1.23382505195217
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/507	133/9376	1.39045839450698	RAC2/CD48/GZMB/CD247/FCGR3B/HCST/PRF1/PRKCA/KLRC1/LCK	1.0842923621898
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/507	56/9376	1.65116934347704	KRTCAP2/ST6GAL1/OSTC/TMEM258/DAD1	1.16850962460669
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	20/507	298/9376	1.24114742596932	TNFRSF12A/BMP2/XCL2/IL7R/LEPR/XCL1/IL13RA2/CXCL8/IL15/TGFB2/CXCL14/CXCR2/CX3CR1/INHBB/CXCR4/CXCL11/IL36RN/CXCL2/IL21R/CCR7	1.01145825639768
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	10/507	134/9376	1.38008183932409	GUCY1A1/MYH14/RAMP3/RAMP1/MYL9/KCNMB4/PPP1CB/AVPR1A/PRKCA/KCNMA1	1.05949479283875
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/507	87/9376	1.48795030492643	RAC2/AREG/GADD45A/EREG/TGFB2/TCF7/LEF1	1.09320857357142
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	20/507	300/9376	1.23287310979619	JUND/RAC2/ANGPT2/AREG/FLNA/PDGFD/MAP3K13/GADD45A/EREG/HSPA1B/STK4/CACNA2D1/DUSP2/TGFB2/RRAS2/PTPN7/PRKCA/DDIT3/PDGFRA/EFNA5	0.980133011991439
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/507	89/9376	1.45451321942247	SLC38A1/GNG5/GNB5/GABRG2/PRKCA/GABARAP/GNG2	1.03004474325881
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/507	137/9376	1.34986106911991	CTSW/GZMB/ACTB/CTSS/GADD45A/PRF1/TUBA4A/DDIT3/BIRC3/TRAF1	0.986269741720612
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/507	105/9376	1.40899783976707	TOMM7/UBA52/RPS27A/HIF1A/MAP1LC3B/RRAS2/GABARAP/SQSTM1	1.0076382931643
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/507	170/9376	1.30539505743126	ACTN1/MYH14/ACTB/MYL12A/TIAM1/CLDN1/YBX3/MYL9/MYL12B/PATJ/TUBA4A/ARPC3	0.960734242054933
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/507	170/9376	1.30539505743126	WNT5A/ACTB/GSTP1/GADD45A/GSTT2B/TXNRD2/TGFB2/WNT2/PRKCA/MGST1/TCF7/LEF1	0.960734242054933
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/507	44/9376	1.68119060426753	KRTCAP2/OSTC/TMEM258/DAD1	1.08282908543292
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/507	44/9376	1.68119060426753	GZMB/PRF1/CPE/HLA-DRB5	1.08282908543292
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/507	59/9376	1.56721158024939	DPYD/NME3/NME2/CDA/NT5E	1.04492552329243
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/507	122/9376	1.36424483461053	CD247/CD3G/PTPRC/CD3D/ITK/CD3E/PPP2R5C/CARD11/LCK	0.968190595665619
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/507	45/9376	1.64383081306158	GZMB/PRF1/KLRC1/HLA-DRB5	1.03506163199401
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/507	140/9376	1.32093547478163	CCN2/MAP1LC3B/APLN/PLAT/GNG5/CAMK4/GNB5/RRAS2/GNG2/PIK3R5	0.914728205863048
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/507	61/9376	1.5158275940117	FTH1/ATP2B1/STEAP1/MT2A/ATOX1	0.966340873043851
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/507	17/9376	2.17565842905209	CYP7B1/SCP2	1.15996047037775
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/507	31/9376	1.78965451422027	SEC61B/SPCS1/HSPA5	1.05288419608648
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/507	109/9376	1.35729149702332	CD247/HIF1A/CD3G/CD3D/CD3E/IL21R/LCK/HLA-DRB5	0.897054106583255
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/507	93/9376	1.39195351106021	GUCY1A1/CST3/ATP2B1/LYZ/BST1/PRKCA/KCNMA1	0.908205543908519
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/507	62/9376	1.49137876185023	CRYAB/SOD2/SOD1/HSPA1B/IRS2	0.928103477738083
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/507	110/9376	1.34495248341402	THBS1/DCN/BMP2/SMAD1/RBX1/TGFB2/INHBB/ID4	0.870085158982009
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/507	78/9376	1.42254589591868	FCGR3B/EEF1A1/ITGA4/PTGS2/TGFB2/HLA-DRB5	0.895939550766833
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/507	333/9376	1.16623132007747	THBS1/WNT5A/LAMB3/CCND2/ITGB6/PTGER4/IRF1/PPP2R5C/ATP6V1G1/ITGA4/PKM/PTGS2/TNC/LAMA3/WNT2/PATJ/LAMB1/ATP6V0E1/TCF7/CREB5/LAMC2	0.738466834681691
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/507	34/9376	1.63174382178907	POLR2L/POLR2I/POLR2G	0.882292974076732
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/507	34/9376	1.63174382178907	NR1D1/RBX1/NR1D2	0.882292974076732
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/507	82/9376	1.35315341319094	CTSS/HSPA1B/CALR/KLRC1/HSPA5/HLA-DRB5	0.767929392547228
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/507	50/9376	1.47944773175542	ITGA4/IL15/CXCR4/HLA-DRB5	0.812701114582698
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/507	149/9376	1.24114742596932	PDGFD/CXCL8/CXCR2/AVPR1A/RRAS2/RAPGEF4/PRKCA/PDGFRA/F2R/PIK3R5	0.709410798460395
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/507	200/9376	1.20205128205128	MYH14/ACTB/RPS3/GAPDH/CLDN1/TMED10/MYO1D/CXCL8/TUBA4A/CYFIP2/ARPC3/F2R/BRK1	0.690561236440949
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/507	253/9376	1.16952389862089	ACTN1/UBA52/ACTB/RPS27A/MYL12A/MAP1LC3B/PFN2/UBE2V1/MYL9/CAST/CXCL8/RBX1/MYL12B/ARPC3/SQSTM1/SEPTIN6	0.653543718879626
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/507	20/9376	1.84930966469428	EBP/CYP51A1	0.909050997780706
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/507	20/9376	1.84930966469428	CYB5R1/NANS	0.909050997780706
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/507	67/9376	1.38008183932409	PFKP/GAPDH/PKM/PGM1/ENO1	0.746475048549525
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/507	101/9376	1.2816997676099	VCAM1/F3/CXCL8/TGFB2/SELE/PRKCA/MMP2	0.680522528355312
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/507	238/9376	1.16553130127791	RAC2/ANGPT2/PDGFD/TIAM1/PLAAT2/STK4/GNG5/REL/GNB5/RRAS2/PRKCA/PDGFRA/GNG2/RASAL3/EFNA5	0.618436795616461
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/507	69/9376	1.34007946716977	TH/CAMK4/PPP1CB/PRKCA/CREB5	0.677879328138209
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/507	86/9376	1.29021604513554	KCNMB4/RAPGEF4/PRKCA/CREB5/KCNN3/KCNMA1	0.646420437155547
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/507	53/9376	1.39570540731644	ATP2B1/AP2S1/CLTB/PRKCA	0.690691908185654
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/507	103/9376	1.25681239348155	CD247/CD3G/CD3D/CD3E/CXCL8/TGFB2/CALR	0.626580321682572
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/507	37/9376	1.49944026867104	GADD45A/TCF7/LEF1	0.72775721594346
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/507	139/9376	1.19739474692435	KRT24/KRT17/KRT14/KRT10/KRT16/HSPA1B/CREB5/MMP2/KRT18	0.560569945573606
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/507	38/9376	1.45998131423233	SFN/PRKCA/NR3C2	0.679293319695547
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/507	71/9376	1.3023307497847	ATP6V1G1/CXCL8/CXCR2/CXCL2/ATP6V0E1	0.611372073779986
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/507	71/9376	1.3023307497847	HIF1A/PFKP/PKM/PDGFRA/SLC7A5	0.611372073779986
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/507	39/9376	1.42254589591868	GZMB/PRF1/HLA-DRB5	0.632200452566105
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/507	194/9376	1.14390288537791	MYH14/ACTB/KLC3/MYL12A/DYNLT3/DYNLL1/MYL9/MYO1D/MYL12B/TUBA4A/DYNLT1/DCTN3	0.484232587811356
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/507	56/9376	1.32093547478163	EEF1A1/HSPA1B/CXCL8/CXCL2	0.575911926623546
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/507	90/9376	1.23287310979619	CD247/HIF1A/CD3G/CD3D/CD3E/LCK	0.530736001595017
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/507	73/9376	1.26665045527005	MAP1B/ELL2/APOBEC3A/CXCR4/APOBEC3C	0.546820187562297
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/507	178/9376	1.14283181526051	RAC2/WNT5A/DKK1/CCND2/FOSL1/RBX1/CACYBP/WNT2/PRKCA/TCF7/LEF1	0.459981690143413
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/507	91/9376	1.21932505364458	PDE3A/GNG5/GNB5/GABRG2/PRKCA/GNG2	0.502655312357043
Organismal Systems	Immune system	hsa04611	Platelet activation	8/507	126/9376	1.17416486647256	GUCY1A1/ACTB/MYL12A/PPP1CB/MYL12B/F2R/PIK3R5/APBB1IP	0.470573262929073
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/507	59/9376	1.25376926419951	GSTP1/GSTT2B/GGCT/MGST1	0.467497474350966
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/507	166/9376	1.1140419666833	GUCY1A1/PDE3A/ATP2B1/MYL9/KCNMB4/PPP1CB/PIK3R5/IRS2/CREB5/KCNMA1	0.354438767385212
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/507	78/9376	1.18545491326556	ACTB/CLTB/SEPTIN1/ARPC3/SEPTIN6	0.393226850109153
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/507	44/9376	1.26089295320065	ARHGDIB/DYNLL1/CREB5	0.414718694210294
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/507	115/9376	1.12566675242261	GNG5/CAMK4/GNB5/PRKCA/GNG2/PIK3R5/CREB5	0.324184808995313
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/507	133/9376	1.11236671560558	SOD2/CCND2/GADD45A/IL7R/STK4/TGFB2/GABARAP/IRS2	0.312039318937752
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/507	133/9376	1.11236671560558	TH/PPP2R5C/GNG5/PPP1CB/GNB5/PRKCA/GNG2/CREB5	0.312039318937752
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/507	187/9376	1.08782921452605	TXN/TNFAIP3/CARD16/MAP1LC3B/CXCL8/CXCL2/GBP2/BIRC3/NAMPT/GABARAP/GBP5	0.290053404065233
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/507	169/9376	1.0942660737836	UBA52/RPS27A/HIF1A/MAP1LC3B/VMP1/RRAS2/GABARAP/SQSTM1/IRS2/WDR45	0.29565960345561
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/507	27/9376	1.36985901088465	HACD4/SCP2	0.460137677925403
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/507	224/9376	1.07326007326007	CCND2/CD3G/FOSL1/CD3D/CD3E/IL15/TGFB2/CALR/TSPO/CREB5/LCK/HLA-DRB5/ZFP36	0.265329563456168
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/507	98/9376	1.13223040695568	RAC2/PTPRC/FCGR3B/PRKCA/ARPC3/GSN	0.31460779487186
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/507	99/9376	1.12079373617835	RAC2/HIF1A/PDGFD/SLC22A4/PRKCA/PDGFRA	0.288875375971311
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/507	99/9376	1.12079373617835	ACTB/ITGB6/ITGA4/CACNA2D1/TGFB2/SNTB1	0.288875375971311
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/507	226/9376	1.06376219650556	RAC2/PDE3A/ATP2B1/TIAM1/SSTR1/MYL9/CAMK4/PPP1CB/RRAS2/RAPGEF4/F2R/CREB5/HCAR3	0.231984640910294
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/507	28/9376	1.32093547478163	B3GNT3/B3GNT5	0.406620882850905
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/507	28/9376	1.32093547478163	ATP6V1G1/ATP6V0E1	0.406620882850905
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/507	154/9376	1.0807653884577	GUCY1A1/ACTB/MYL9/PTGS2/CACNA2D1/CAMK4/PPP1CB/PRKCA/PIK3R5	0.241615826374577
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/507	136/9376	1.08782921452605	TNFAIP3/CCND2/CD3G/CD3D/CD3E/HSPA1B/SLAMF1/RAB9A	0.246674784678914
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/507	227/9376	1.05907601942844	RAC2/PTGER4/CXCL8/PTGS2/GNG5/GNB5/CXCR2/CALR/CXCR4/PRKCA/PDGFRA/GNG2/CREB5	0.215421789811794
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	5/507	83/9376	1.1140419666833	SOD2/SOD1/DHRS4/SCP2/CROT	0.249504318110745
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/507	47/9376	1.18041042427294	PKM/SOCS2/IRS2	0.296445799311034
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/507	138/9376	1.07206357373581	RAC2/ACTB/FYB1/ITGA4/CXCL8/ARHGEF28/ARPC3/LCK	0.203900668795381
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/507	102/9376	1.08782921452605	ATP2B1/BST1/PRSS3/RAB27B/PRKCA/KCNMA1	0.213234675359348
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/507	66/9376	1.12079373617835	STAT4/TGFB2/IL21R/HLA-DRB5	0.235447363691201
NA	NA	hsa03272	Virion - Hepatitis viruses	3/507	48/9376	1.15581854043392	CD9/CLDN1/EPCAM	0.258760375297411
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/507	12/9376	1.54109138724523	SLAMF1	0.448417788074641
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/507	85/9376	1.08782921452605	NME3/NME2/CDA/NT5E/GDA	0.194477571196355
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/507	142/9376	1.04186459982776	JUND/FCGR3B/FOSL1/CAMK4/TGFB2/FHL2/SQSTM1/LCK	0.120184502972276
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/507	105/9376	1.0567483798253	ACTB/ITGB6/ITGA4/CACNA2D1/TGFB2/SNTB1	0.139809639629328
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/507	68/9376	1.08782921452605	DHRS3/ALDH1A1/DHRS9/DHRS4	0.173787108836087
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/507	31/9376	1.19310300948018	HYI/GRHPR	0.257473494087702
NA	NA	hsa04981	Folate transport and metabolism	2/507	31/9376	1.19310300948018	BHMT2/FOLH1	0.257473494087702
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/507	69/9376	1.07206357373581	GUCY1A1/PDE3A/PTGER4/KCNMA1	0.143644093993143
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/507	32/9376	1.15581854043392	PFKP/PGM1	0.21109599639901
NA	NA	hsa04081	Hormone signaling	12/507	219/9376	1.01332036421604	PENK/RAMP3/RAMP1/SSTR1/LEPR/SMAD1/GNG5/GNB5/AVPR1A/RAPGEF4/GNG2/IRS2	0.0476885195754497
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/507	70/9376	1.0567483798253	GSTP1/GSTT2B/PTGS2/MGST1	0.113939222922382
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/507	70/9376	1.0567483798253	HIF1A/ELOB/RBX1/TGFB2	0.113939222922382
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/507	89/9376	1.03893801387319	GUCY1A1/PDGFD/PRKCA/TUBA4A/PDGFRA	0.088243630304048
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/507	71/9376	1.04186459982776	TH/CCND2/IRF1/SOCS2	0.084658431975231
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/507	90/9376	1.02739425816349	SOD2/SESN3/CAMK4/IRS2/CREB5	0.0624336534908498
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/507	128/9376	1.01134122287968	GUCY1A1/PDE3A/NME3/NME2/NT5E/PGM1/GDA	0.03088824618664
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/507	205/9376	0.992312503006687	RUNX3/TNFAIP3/CD247/CCND2/CD3G/GADD45A/CD3D/CD3E/CALR/SEM1/HLA-DRB5	-0.0266076079708509
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/507	130/9376	0.995782127143074	MMP1/GNG5/GNB5/PRKCA/GNG2/CREB5/MMP2	-0.0115781855788765
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/507	168/9376	0.990701606086221	CCND2/STAT4/IL7R/LEPR/IL13RA2/IL15/SOCS2/IL21R/PDGFRA	-0.0290758363958321
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/507	54/9376	1.02739425816349	GZMB/PRF1/HLA-DRB5	0.0482674288716967
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/507	75/9376	0.986298487836949	GSTP1/GSTT2B/BIRC3/MGST1	-0.0284830571001192
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/507	36/9376	1.02739425816349	B3GNT3/GALNT15	0.0393721967712493
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/507	76/9376	0.973320876154884	GADD45A/CAMK4/PRKCA/PDGFRA	-0.0558327700683963
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/507	154/9376	0.96068034529573	ATP2B1/PPP2R5C/CACNA2D1/PPP1CB/RAPGEF4/PRKCA/PIK3R5/CREB5	-0.117627749281629
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/507	37/9376	0.999626845780692	PGM1/NANS	-0.00054374004820205
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/507	116/9376	0.956539481738421	PFKP/GAPDH/PKM/TALDO1/TKT/ENO1	-0.112608375312119
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/507	97/9376	0.953252404481588	GUCY1A1/GNG5/GNB5/PRKCA/GNG2	-0.110648835553795
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/507	17/9376	1.08782921452605	TXNRD2	0.0866564764705374
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/507	17/9376	1.08782921452605	MYH14	0.0866564764705374
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/507	98/9376	0.943525339129735	ATP2B1/CAMK4/PRKCA/PRKD1/CREB5	-0.134366738570843
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/507	157/9376	0.942323396022563	THBS1/ATP11B/HIF1A/PTGER4/PTGS2/DUSP2/CX3CR1/CALR	-0.174244825627722
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/507	157/9376	0.942323396022563	IGFBP3/CCND2/GADD45A/CXCL8/TGFB2/PPP1CB/RRAS2/SQSTM1	-0.174244825627722
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/507	79/9376	0.936359323895838	ATP6V1G1/AP2S1/CLTB/ATP6V0E1	-0.135809204524633
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/507	216/9376	0.941778069983198	VCAM1/SOD2/SELP/MMP1/HSPA1B/CXCL8/SELE/PRKCA/CXCL2/DDIT3/HSPA5	-0.206975064718327
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/507	59/9376	0.940326948149634	PLAAT2/PTGS2/IRS2	-0.109930574590499
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/507	59/9376	0.940326948149634	GADD45A/TCF7/LEF1	-0.109930574590499
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/507	60/9376	0.92465483234714	RAC2/PTGS2/PRKCA	-0.139980834826089
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/507	101/9376	0.915499834007069	WNT5A/WNT2/PRKCA/TCF7/LEF1	-0.204133170204051
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/507	122/9376	0.909496556407023	IGFBP3/SSTR1/PRKCA/SOCS2/IRS2/CREB5	-0.240565066779234
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/507	103/9376	0.897723138201107	COL12A1/COL8A1/COL5A2/PRSS3/MME	-0.249538848565104
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/507	144/9376	0.898969975893053	WNT5A/HAND1/SMAD1/INHBB/WNT2/ID4/TCF7	-0.292103052343646
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/507	63/9376	0.880623649854419	PLAAT2/PTGDS/PTGS2	-0.227298233308546
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/507	42/9376	0.880623649854419	FTH1/MAP1LC3B	-0.185379340942417
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/507	65/9376	0.853527537551206	PRKCA/KISS1/KCNN3	-0.283313186179447
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/507	44/9376	0.840595302133764	TAF4B/GTF2H5	-0.253391697012337
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/507	66/9376	0.840595302133764	SULT2B1/CYP7B1/DHRS9	-0.310706639764686
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	12/507	250/9376	0.887668639053254	OSBPL1A/CTSW/NCOA7/CTSS/ATP6V1G1/AP2S1/CLTB/ATP6V0E1/LAMTOR4/LITAF/ABCA5/OSBPL3	-0.430410723575013
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/507	67/9376	0.828049103594454	CAMK4/PPP1CB/PRKCA	-0.337708989123831
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/507	46/9376	0.804047680301861	FTH1/BLVRA	-0.318522997048853
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/507	46/9376	0.804047680301861	PSMD9/SEM1	-0.318522997048853
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/507	68/9376	0.815871910894535	TCF7/PIM2/LEF1	-0.364333080215152
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/507	23/9376	0.804047680301861	MME	-0.224952668997397
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/507	47/9376	0.78694028284863	PKM/GRHPR	-0.350094283112845
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/507	91/9376	0.812883369096387	IFITM1/RAC2/DAPP1/CARD11	-0.428839145328427
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/507	49/9376	0.754820271303788	ST6GAL1/GALNT15	-0.411399635136293
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/507	49/9376	0.754820271303788	TH/CREB5	-0.411399635136293
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/507	115/9376	0.804047680301861	PTGS2/GNG5/GNB5/PRKCA/GNG2	-0.505501766448949
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/507	115/9376	0.804047680301861	JUND/NACA/STK39/PRKCA/CREB5	-0.505501766448949
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/507	158/9376	0.819314408408858	SFN/CCND2/GADD45A/PPP2R5C/RBX1/TGFB2/YWHAZ	-0.547628452269508
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/507	116/9376	0.797116234782017	SLC38A1/GNG5/GNB5/PRKCA/GNG2	-0.525681977396012
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/507	50/9376	0.739723865877712	CKB/P4HA3	-0.441188246998243
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/507	73/9376	0.759990273162033	GSTP1/GSTT2B/MGST1	-0.492188035881638
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/507	73/9376	0.759990273162033	PDGFD/GADD45A/PDGFRA	-0.492188035881638
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/507	73/9376	0.759990273162033	GADD45A/STK4/PRKCA	-0.492188035881638
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/507	26/9376	0.711272947959339	PLAAT2	-0.352468764021708
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/507	26/9376	0.711272947959339	NR5A2	-0.352468764021708
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/507	26/9376	0.711272947959339	FOLH1	-0.352468764021708
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/507	75/9376	0.739723865877712	PRKCA/HSPA5/CREB5	-0.541068744951785
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/507	52/9376	0.711272947959339	VAPA/TSPO	-0.499160609637196
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/507	28/9376	0.660467737390814	HACD4	-0.430182760171502
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/507	28/9376	0.660467737390814	TH	-0.430182760171502
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/507	77/9376	0.720510258971797	RAC2/GADD45A/TGFB2	-0.588769630474595
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/507	122/9376	0.757913797005852	PFKP/LEPR/PPP2R5C/IRS2/CREB5	-0.643483620927518
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/507	54/9376	0.684929505442326	BCAT1/BHMT2	-0.555139788596342
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/507	78/9376	0.711272947959339	BTG1/PFKP/ENO1	-0.612198551206206
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/507	55/9376	0.672476241707011	CERS6/SGMS2	-0.582431949057292
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/507	79/9376	0.702269492921879	GSTP1/GSTT2B/MGST1	-0.635356910143686
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/507	30/9376	0.616436554898093	PIGP	-0.503080217685315
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/507	30/9376	0.616436554898093	PLAAT2	-0.503080217685315
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/507	125/9376	0.739723865877712	RAC2/CERS6/PPP2R5C/PRKCA/SGMS2	-0.70040188136924
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/507	56/9376	0.660467737390814	CCND2/GAS1	-0.609283469342733
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/507	80/9376	0.693491124260355	PDGFD/PRKCA/PDGFRA	-0.658252142782232
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/507	191/9376	0.774579964269856	TH/GNG5/CAMK4/PPP1CB/GNB5/PKIA/GNG2/CREB5	-0.752526690460156
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/507	57/9376	0.648880584103256	HACD4/SCP2	-0.635711265621926
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/507	31/9376	0.59655150474009	DPYD	-0.537937207911076
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/507	150/9376	0.739723865877712	WNT5A/GADD45A/TGFB2/WNT2/TCF7/LEF1	-0.768290640160564
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/507	32/9376	0.577909270216962	GABARAP	-0.571829661131495
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/507	32/9376	0.577909270216962	BIRC3	-0.571829661131495
Human Diseases	Immune disease	hsa05310	Asthma	1/507	32/9376	0.577909270216962	HLA-DRB5	-0.571829661131495
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/507	323/9376	0.80155836859814	THBS1/CCND2/HOXD10/SERPINB5/PTGS2/HMGA2/TGFB2/TNC/PRKCA/PDGFRA/PDCD4/IRS2/SOX4/EFNA5	-0.867740924416457
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/507	33/9376	0.560396868089176	BCAT1	-0.604821002624138
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/507	33/9376	0.560396868089176	STX11	-0.604821002624138
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/507	60/9376	0.616436554898093	GUCY1A1/PRKCA	-0.712607495964576
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/507	86/9376	0.645108022567772	AREG/EREG/PRKCA	-0.790478097403583
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/507	35/9376	0.528374189912652	PFKP	-0.668324205430534
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/507	158/9376	0.702269492921879	WNT5A/ATP6V1G1/WNT2/PRKCA/LAMTOR4/SLC7A5	-0.902372432404847
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/507	36/9376	0.513697129081744	PGM1	-0.698935237083217
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/507	36/9376	0.513697129081744	POLE4	-0.698935237083217
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/507	181/9376	0.715202632754694	CTSS/FCGR3B/CORO1A/TGFB2/ITGAX/MRC2/HLA-DRB5	-0.925021189587789
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/507	205/9376	0.721681820368499	ACTN1/CCND2/PKM/REL/GSN/CREB5/YWHAZ/TRAF1	-0.963301972181229
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/507	37/9376	0.499813422890346	FOLH1	-0.728844696039865
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/507	37/9376	0.499813422890346	TH	-0.728844696039865
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	10/507	250/9376	0.739723865877712	RAB11FIP1/ARF5/HSPA1B/CXCR2/AP2S1/CLTB/CXCR4/VPS37B/PDGFRA/ARPC3	-0.997278393787027
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/507	38/9376	0.486660438077442	PGM1	-0.758091957999206
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/507	163/9376	0.680727483936545	STAT4/CXCL8/TGFB2/PRKCA/CREB5/YWHAZ	-0.983121269034928
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/507	39/9376	0.474181965306226	BHMT2	-0.786713118531394
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/507	69/9376	0.536031786867907	RAC2/PRKCA	-0.924826374296989
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/507	41/9376	0.451051137730312	GRHPR	-0.84220719434266
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/507	41/9376	0.451051137730312	SEM1	-0.84220719434266
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/507	41/9376	0.451051137730312	GABRG2	-0.84220719434266
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/507	70/9376	0.528374189912652	LEPR/IRS2	-0.946928854654833
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/507	122/9376	0.606331037604682	ACTB/HIF1A/PFKP/PRKCA	-1.0464021750758
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/507	72/9376	0.513697129081744	CXCL8/RNF125	-0.990354139591932
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/507	148/9376	0.624766778612933	WNT5A/GADD45A/WNT2/TCF7/LEF1	-1.10009613026356
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/507	99/9376	0.560396868089176	PTGER4/PPP1CB/PRKCA	-1.05130053947006
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/507	44/9376	0.420297651066882	POLE4	-0.921502088234968
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/507	45/9376	0.410957703265396	ABCA5	-0.946980275877699
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/507	76/9376	0.486660438077442	MMP1/SCP2	-1.07429201551837
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/507	76/9376	0.486660438077442	ACTB/PRKCA	-1.07429201551837
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/507	103/9376	0.538633882920664	PPP2R5C/PPP1CB/SAP18	-1.12565801881278
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/507	77/9376	0.480340172647865	GADD45A/TGFB2	-1.09470896283
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/507	155/9376	0.59655150474009	WNT5A/WNT2/TCF7/CREB5/LEF1	-1.21092495274331
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/507	105/9376	0.528374189912652	IRF1/PTGS2/RRAS2	-1.16193334067313
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/507	78/9376	0.474181965306226	IRF1/CXCL8	-1.11491125186389
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/507	48/9376	0.385272846811308	BCAT1	-1.02084789410582
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/507	107/9376	0.518498036830172	PFKP/PKM/CREB5	-1.19763864255276
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/507	108/9376	0.513697129081744	EEF1A1/SUMO2/SAP18	-1.21528458453161
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/507	254/9376	0.655267204025532	ATP2B1/ASPH/PDGFD/CAMK4/AVPR1A/CXCR4/PRKCA/PDGFRA/F2R	-1.33170097136636
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/507	109/9376	0.508984311383747	PPP1CB/IRS2/CREB5	-1.23279631208593
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/507	51/9376	0.362609738175349	PLAAT2	-1.09123523917556
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/507	370/9376	0.699738792046484	PENK/GZMA/LYPD6B/SSTR1/P2RY8/LEPR/PTGER4/APLN/PRSS3/GABRG2/AVPR1A/KISS1/TSPO/F2R	-1.4089202416102
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/507	52/9376	0.355636473979669	PTGS2	-1.11399637894334
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/507	138/9376	0.536031786867907	PPP2R5C/RBX1/PPP1CB/YWHAZ	-1.31277737216098
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/507	168/9376	0.550389781159012	FTH1/TNFAIP3/STAT4/BIRC3/SQSTM1	-1.40591948309948
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/507	144/9376	0.513697129081744	CXCL8/CXCL2/TCF7/LEF1	-1.40602315217039
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/507	195/9376	0.569018358367471	RAC2/SELP/ACTB/FCGR3B/PRKCA/AQP9	-1.45406350195726
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/507	173/9376	0.53448256205037	ACTB/CXCL8/PRSS3/PRKCA/HLA-DRB5	-1.47756496529771
NA	NA	hsa04082	Neuroactive ligand signaling	6/507	199/9376	0.557580803425411	PENK/GNG5/GNB5/GABRG2/PRKCA/GNG2	-1.50821211673613
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/507	93/9376	0.39770100316006	PRKCA/MMP2	-1.39560246964223
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/507	154/9376	0.480340172647865	NME3/NME2/DHRS3/BCAT1	-1.55460205190645
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/507	98/9376	0.377410135651894	PRKCA/SYNJ2	-1.48129033889895
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/507	65/9376	0.284509179183735	CREB5	-1.38393238386683
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/507	104/9376	0.355636473979669	PLAAT2/SGMS2	-1.57984033612641
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/507	138/9376	0.40202384015093	PPP1CB/SOCS2/IRS2	-1.69194688240007
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/507	109/9376	0.339322874255831	CXCL8/CXCL11	-1.65876639581976
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/507	143/9376	0.387967062523276	ACTN1/FCGR3B/HLA-DRB5	-1.76328976376809
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/507	144/9376	0.385272846811308	PRKCA/PSMD9/SEM1	-1.77732985211264
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/507	78/9376	0.237090982653113	SYNJ2	-1.61762395252156
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/507	180/9376	0.410957703265396	PPP1CB/CALR/BIRC3/HLA-DRB5	-1.90781185221919
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/507	83/9376	0.22280839333666	L3MBTL4	-1.70036230960865
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/507	83/9376	0.22280839333666	POLR2L	-1.70036230960865
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/507	120/9376	0.308218277449047	ARHGDIB/CAMK4	-1.82347714302983
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/507	90/9376	0.205478851632698	AQP9	-1.81077573892582
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/507	99/9376	0.186798956029725	MMP2	-1.94475114976431
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/507	217/9376	0.340886574137194	GSTT2B/PRKCA/MGST1/CREB5	-2.34864991182502
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/507	156/9376	0.237090982653113	CLDN1/YWHAZ	-2.29732202990883
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/507	117/9376	0.158060655102075	ACTB	-2.19100810631025
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/507	243/9376	0.304413113529923	HSPA1B/DDX5/HNRNPA1/SF3B5	-2.62663716110891
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/507	183/9376	0.202110345868227	REXO2/NOP10	-2.6061057775729
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/507	449/9376	0.041187297654661	NCALD	-4.97801811260041