category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	36/278	250/9376	4.85663309352518	PSAP/CTSD/HEXB/LGMN/LAPTM5/ASAH1/CD63/CD68/GNS/LAMP1/CLN8/LIPA/ATP6V0C/TPP1/MITF/CTSB/CTSA/AP1S2/ATP6V0B/NPC2/ACP5/HEXA/ATP6V0E1/SLC29A1/ATP6V0A1/SLC17A5/CTSS/CTSK/CTSW/RRAGD/CTSH/ATP6V1G1/ATP6AP1/NEU1/ATP6V0D2/GAA	10.8037161581646
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/278	95/9376	7.45535781900795	HLA-DRB5/HLA-DQA2/TNFSF13B/TNF/CCL3/CXCL3/CXCL2/ITGB2/HLA-DMB/ATP6V0C/JUN/CCL5/ATP6V0B/FOS/ACP5/ATP6V0E1/ATP6V0A1/CTSK/ATP6V1G1/ATP6AP1/ATP6V0D2	11.0540088089074
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/278	155/9376	5.22218612207009	HLA-DRB5/HLA-C/MARCO/HLA-DQA2/HLA-A/ITGB2/HLA-DMB/LAMP1/CD14/ATP6V0C/HLA-E/HLA-F/COLEC12/ATP6V0B/ATP6V0E1/NCF1/ATP6V0A1/TAP1/CTSS/FCGR3A/ATP6V1G1/FCGR2A/ATP6AP1/ATP6V0D2	9.26508231034732
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/278	82/9376	6.99210387787331	HLA-DRB5/HLA-C/B2M/HLA-DQA2/HLA-A/TNF/LGMN/HLA-DMB/HLA-E/HLA-F/IFI30/CTSB/KLRD1/TAP1/CTSS/KLRC1/TAPBP	9.52620659059189
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/278	205/9376	3.78396209861379	HLA-DRB5/HLA-C/B2M/NFKBIA/HLA-DQA2/HLA-A/GADD45B/VIM/TNF/CDKN1A/ISG15/HLA-DMB/CXCL10/JUN/HLA-E/HLA-F/MDM2/DDB2/BAX/TAP1/FAS/MAP2K3/TAPBP	7.04477248902386
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/278	45/9376	8.24428457234213	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/KLRD1/FAS/KLRC1	8.51476633007221
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/278	109/9376	4.950696323675	NFKBIA/CXCL9/TNF/MAP3K8/CCL3/CXCL11/CCL4/CXCL10/CD14/JUN/CCL5/TICAM1/FOS/LY96/CTSK/MAP2K3	7.25190966587744
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/278	71/9376	6.17529638261222	NFKBIA/CXCL3/CXCL2/ATP6V0C/JUN/CCL5/ATP6V0B/ATP6V0E1/ATP6V0A1/ADAM17/ATP6V1G1/ATP6AP1/ATP6V0D2	7.65140661131139
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/278	142/9376	4.27520518796231	NFKBIA/TNF/JUN/MITF/JUNB/FOSL1/FOS/ACP5/NCF1/LILRB4/SQSTM1/FOSB/FCGR3A/CTSK/JUND/PPARG/SIRPA/FCGR2A	6.8742103955776
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/278	100/9376	5.05899280575539	CXCL9/TNF/CCL3/CXCL3/CXCL2/CXCR4/CXCL11/CCL4/CXCL10/CCL18/XCL1/CCL5/XCL2/TNFRSF14/IL10RA	7.13301244101345
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/278	181/9376	3.72669819945149	HLA-DRB5/HLA-DQA2/CTSD/TNF/ITGB2/HLA-DMB/LAMP1/CD14/ATP6V0C/CLEC4E/RIPK2/ATP6V0B/ATP6V0A1/BAX/IL10RA/CTSS/FCGR3A/FCGR2A/ATP6AP1/ATP6V0D2	6.47493721998923
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/278	180/9376	3.56003197442046	HLA-DRB5/HLA-C/B2M/NFKBIA/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/PILRA/CCL5/HLA-F/TICAM1/TNFRSF14/BAX/TAP1/FAS/RHEB/TAPBP	6.06201812837186
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/278	39/9376	7.7830658550083	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/FAS	7.4197577750276
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/278	78/9376	5.18871057000553	HLA-DRB5/NFKBIA/HLA-DQA2/TNF/ITGB2/HLA-DMB/JUN/FOS/NCF1/EEF1A1/FCGR3A/FCGR2A	6.49333714875115
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	21/278	224/9376	3.16187050359712	HLA-DRB5/HLA-C/B2M/NFKBIA/HLA-DQA2/HLA-A/TNF/CDKN1A/ITGB2/ZFP36/HLA-DMB/EGR1/JUN/HLA-E/HLA-F/FOSL1/FOS/BAX/EGR2/TSPO/ANAPC16	5.7244102335612
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/278	44/9376	6.89862655330281	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/FAS	6.85527600026699
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/278	196/9376	3.26941711936573	HLA-C/NFKBIA/HLA-A/UBC/CXCL3/CDKN1A/CXCL2/ZFP36/RCAN1/CLEC2B/MAP1LC3B/JUN/HLA-E/MICA/HLA-F/TICAM1/FOS/BAX/FAS	5.61249660921065
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/278	119/9376	3.96783749471011	NFKBIA/TNF/MAP3K8/CXCL3/CXCL2/CXCL10/IRF1/JUN/CCL5/JUNB/FOS/ADAM17/FAS/MAP2K3	5.69525974731415
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/278	227/9376	2.97150825595031	HLA-C/B2M/NFKBIA/HLA-A/TNF/CCL3/CDKN1A/GNAS/CXCR4/CCL4/HLA-E/CCL5/HLA-F/MDM2/BAX/TAP1/IL10RA/FAS/RHEB/TAPBP	5.25605359252116
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/278	51/9376	5.95175624206517	GNAS/ATP6V0C/ATP6V0B/ATP6V0E1/ATP6V0A1/ATP6V1G1/ATP6AP1/ATP6V0D2/ARF1	6.19804885885488
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/278	56/9376	5.42034943473792	NFKBIA/TNF/CXCL3/CXCL2/ITGB2/CD14/EEF1A1/VCP/ARF1	5.79932876292634
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/278	70/9376	4.81808838643371	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/ITGB2/HLA-DMB/HLA-E/HLA-F/DTNA/ABL2	5.60465060339494
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	24/278	333/9376	2.43074729405665	HLA-C/FN1/HLA-A/TNF/CDKN1A/ISG15/GNAS/IRF1/ATP6V0C/HLA-E/HLA-F/TICAM1/MDM2/ATP6V0B/ATP6V0E1/ATP6V0A1/BAX/FAS/ATP6V1G1/PPP2CB/RHEB/ATP6AP1/BCAP31/ATP6V0D2	4.6469056470892
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/278	137/9376	3.44651578007667	NFKBIA/GADD45B/LMNA/CTSD/TNF/JUN/CTSB/FOS/BAX/CTSS/FAS/CTSK/CTSW/CTSH	5.04232565968749
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/278	216/9376	2.810551558753	NFKBIA/TNF/CCL3/CXCL3/CXCL2/SOD2/CD14/ABCG1/JUN/CCL5/TICAM1/FOS/NCF1/BAX/FAS/LY96/PPARG/MAP2K3	4.70570941513164
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/278	78/9376	4.32392547500461	TNF/ITGB2/SERPING1/IRF1/CD14/JUN/C2/TICAM1/FOS/LY96	5.152747702618
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/278	52/9376	5.18871057000553	APOC1/CYP27A1/LIPA/MYLIP/PLTP/APOE/NPC2/TSPO	5.29439039567204
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/278	187/9376	2.88569999615281	NFKBIA/GBP2/GBP5/TNF/CXCL3/CXCL2/GBP1/MAP1LC3B/GABARAP/P2RX7/JUN/GBP4/CCL5/TICAM1/CTSB/RIPK2	4.55296537563389
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/278	54/9376	4.99653610444977	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/HLA-DMB/HLA-E/HLA-F/FAS	5.14826793639247
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/278	193/9376	2.7959891154434	NFKBIA/CXCL9/CCL3/CXCL3/CXCL2/CXCR4/CXCL11/CCL4/CXCL10/CCL18/XCL1/CCL5/XCL2/CXCL16/NCF1/ARRB2	4.40681818152331
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/278	214/9376	2.67921737376454	HLA-C/B2M/NFKBIA/HLA-A/TNF/CXCR4/JUN/HLA-E/HLA-F/AP1S2/FOS/BAX/TAP1/FAS/CUL1/MAP2K3/TAPBP	4.34363907976557
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/278	103/9376	3.60187190053782	NFKBIA/TNF/CCL3/GNAS/JUN/CCL5/TICAM1/FOS/FAS/SERPINE1/PPP2CB	4.6411912334671
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/278	94/9376	3.58793816011021	NFKBIA/TNF/CXCL3/CXCL2/CXCL10/JUN/FOSL1/FOS/FOSB/JUND	4.40790381443272
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/278	157/9376	2.79264995646795	HLA-C/HLA-A/GADD45B/CDKN1A/HLA-E/ZFP36L2/HLA-F/MDM2/MRAS/SQSTM1/SERPINE1/MAP2K3/RHEB	3.95948300792697
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/278	105/9376	3.21205892428914	NFKBIA/GADD45B/TNFSF13B/TNF/CXCL3/CXCL2/CCL4/CD14/TICAM1/LY96	3.98440173304862
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/278	105/9376	3.21205892428914	UBC/MAP1LC3B/GABARAP/JUN/MITF/MRAS/SQSTM1/PINK1/USP15/VCP	3.98440173304862
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	17/278	248/9376	2.31190531445811	S100A10/NFKBIA/TNF/CD14/ANXA2/JUN/DYNLT1/PLEKHM2/RIPK2/FOS/AHNAK/BAX/LY96/MAP2K3/RAB9A/FLNA/ARF1	3.65995365428938
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/278	144/9376	2.810551558753	NFKBIA/TNF/CXCL3/CXCL2/CD14/C2/TICAM1/ALDH2/FAS/LY96/MAP2K3/ADIPOR1	3.82718375636361
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/278	28/9376	6.02261048304214	ATP6V0C/ATP6V0E1/ATP6V0A1/ATP6V1G1/ATP6V0D2	4.65247697487057
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/278	42/9376	4.81808838643371	FTH1/SAT1/MAP1LC3B/FTL/PCBP2/SLC3A2	4.33482724857604
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/278	298/9376	2.15035488387813	CXCL9/TNFSF13B/TNF/CCL3/CXCL3/CXCL2/CXCR4/CXCL11/CCL4/CXCL10/CCL18/XCL1/CCL5/XCL2/CXCL16/GDF15/TNFRSF14/IL10RA/FAS	3.52760503162587
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/278	163/9376	2.48294125435848	NFKBIA/TNF/CDKN1A/JUN/TICAM1/DDB2/FOS/BAX/EGR2/FAS/MAP2K3/ATP6AP1	3.33850694208066
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/278	253/9376	2.1329086928086	NFKBIA/UBC/TNF/MAP1LC3B/CD14/JUN/CCL5/MDM2/RIPK2/WIPI1/SQSTM1/BAX/RRAGD/CTTN/CUL1/ARF1	3.19316530775674
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/278	169/9376	2.39478949384871	UBC/CTSD/MAP1LC3B/LAMP1/GABARAP/CTSB/WIPI1/MRAS/SQSTM1/RRAGD/PPP2CB/RHEB	3.19836495427764
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/278	37/9376	4.55765117635621	GADD45B/CDKN1A/DDB2/BAX/PPARG	3.79008637911014
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/278	55/9376	3.67926749509483	PSAP/HEXB/ASAH1/HEXA/SGMS2/NEU1	3.4833830634273
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/278	133/9376	2.53583599285985	HLA-C/HLA-A/TNF/ITGB2/HLA-E/MICA/KLRD1/FAS/FCGR3A/KLRC1	3.11816616759045
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/278	75/9376	3.14781774580336	GADD45B/CDKN1A/MDM2/DDB2/BAX/FAS/SERPINE1	3.26436194044502
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/278	300/9376	1.91117505995204	GADD45B/TNF/MAP3K8/RAPGEF2/CD14/JUN/RPS6KA2/FOS/MRAS/FAS/JUND/DUSP10/MAP2K3/ARRB2/FLNA/NR4A1/DUSP1	2.8038209580593
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/278	160/9376	2.31870503597122	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/CD99/ITGB2/HLA-DMB/HLA-E/HLA-F/PTPRM/SDC3	2.94084065061958
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/278	79/9376	2.98843456880066	ATP6V0C/VAMP2/ATP6V0B/ATP6V0E1/ATP6V0A1/ATP6V1G1/ATP6V0D2	3.10233365905265
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/278	99/9376	2.72538332969988	HLA-DRB5/HLA-DQA2/ITGB2/CFD/HLA-DMB/C2/FCGR3A/FCGR2A	3.01671641585766
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/278	15/9376	6.74532374100719	HEXB/ST3GAL1/HEXA	3.89254894786193
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/278	61/9376	3.31737233164288	MT2A/FTH1/MT1X/FTL/ATOX1/ATP1B1	3.17398138383818
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/278	100/9376	2.69812949640288	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/CD14/CD9/CD7/CD38	2.9841833686225
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/278	142/9376	2.37511399331239	TNF/MMP2/GSTO1/JUN/GSTO2/FOS/KLF2/NCF1/SQSTM1/DUSP1	2.88617731269943
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/278	16/9376	6.32374100719424	HEXB/ST3GAL1/HEXA	3.72540983147202
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/278	103/9376	2.61954320039114	FN1/TNF/CXCL3/CXCL2/ITGB2/GNAS/CD14/PRDX1	2.88892381762642
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/278	105/9376	2.56964713943131	NFKBIA/TNF/IRF1/JUN/CLEC4E/MDM2/MRAS/EGR2	2.82727766152736
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/278	173/9376	2.1444670852913	HLA-DRB5/NFKBIA/HLA-DQA2/TNF/HLA-DMB/CXCL10/CCL5/TICAM1/RAB11A/BAX/FAS	2.65580826067412
Human Diseases	Immune disease	hsa05310	Asthma	4/278	32/9376	4.2158273381295	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB	3.18519750645834
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/278	18/9376	5.62110311750599	HEXB/HEXA/NEU1	3.43024754130425
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/278	50/9376	3.3726618705036	HLA-DRB5/HLA-DQA2/TNFSF13B/CXCR4/HLA-DMB	2.94041221064384
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/278	201/9376	2.01352947492752	GADD45B/CDKN1A/ID2/NUPR1/CD14/MITF/MDM2/DDB2/NFKBIZ/BAX/PPARG/ETV7	2.53902189096783
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/278	19/9376	5.32525558500568	HEXB/GNS/HEXA	3.29879502740802
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/278	112/9376	2.40904419321685	HLA-DRB5/NFKBIA/HLA-DQA2/TNF/HLA-DMB/IL10RA/LY96/MAP2K3	2.62222179380824
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/278	205/9376	1.97424109492894	HLA-C/NFKBIA/HLA-A/CDKN1A/SCIN/JUN/HLA-E/HLA-F/MDM2/BAX/EGR2/ATP6V0D2	2.46530183246721
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/278	115/9376	2.34619956208946	CDKN1A/GNAS/EGR1/MAFB/FOS/PLD1/JUND/ARRB2	2.53901047688571
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/278	73/9376	2.77205085246871	GADD45B/CDKN1A/MITF/MDM2/DDB2/BAX	2.65681411657692
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/278	138/9376	2.19956208945887	FN1/NFKBIA/TNF/JUN/TICAM1/RPS6KA2/FOS/FCGR2A/MAP2K3	2.48146621207425
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/278	75/9376	2.69812949640288	CDKN1A/GSTO1/MDM2/GSTO2/BAX/FAS	2.58090301601975
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/278	76/9376	2.66262779250284	UBC/FABP5/CYP27A1/PLTP/PLIN2/PPARG	2.5438730106553
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/278	77/9376	2.62804821078202	NFKBIA/GADD45B/CDKN1A/MDM2/DDB2/BAX	2.50743434367164
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/278	99/9376	2.38471041348739	MMP2/CDKN1A/GNAS/JUN/MDM2/FOS/BAX	2.42107279215633
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/278	101/9376	2.3374884251015	FN1/TNF/MMP2/EGR1/JUN/BAX/SERPINE1	2.36226616687555
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/278	102/9376	2.31457187191423	GNAS/PLA2G2D/RAB11A/ATP1B1/KCNMA1/CD38/PLA2G12B	2.33338254830789
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/278	250/9376	1.75378417266187	HLA-C/HLA-A/CXCR4/FOLR2/HLA-E/ARF5/HLA-F/MDM2/RAB11A/PLD1/ARRB2/IQSEC1/ARF1	2.11160098678509
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/278	44/9376	3.06605624591236	HEXB/B4GALT1/HEXA/TMEM258	2.40113281792254
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/278	87/9376	2.32597370379558	GADD45B/CDKN1A/JUN/DDB2/FOS/BAX	2.17192650967605
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/278	66/9376	2.55504687159363	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/JUN	2.2160302328131
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/278	88/9376	2.29954218443427	ITGB2/SERPING1/CFD/VSIG4/C2/SERPINE1	2.1409458564327
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/278	93/9376	2.17591088419587	HLA-DRB5/NFKBIA/HLA-DQA2/HLA-DMB/JUN/FOS	1.99208001780486
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/278	93/9376	2.17591088419587	MMP2/GNAS/EGR1/JUN/PLD1/MAP2K3	1.99208001780486
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/278	93/9376	2.17591088419587	GNAS/VAMP2/LYZ/ATP1B1/KCNMA1/CD38	1.99208001780486
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/278	93/9376	2.17591088419587	FN1/NFKBIA/GADD45B/CDKN1A/DDB2/BAX	1.99208001780486
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/278	72/9376	2.34212629896083	NFKBIA/TNF/ISG15/CXCL10/ZNFX1	1.9982961594988
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/278	14/9376	4.81808838643371	ST3GAL1/B4GALT1	2.49896830086163
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/278	32/9376	3.16187050359712	GABARAP/WIPI1/PPP2CB	2.14127930803296
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/278	33/9376	3.06605624591236	VAMP5/VAMP2/STX5	2.07821754002596
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/278	200/9376	1.6863309352518	NFKBIA/TNF/JUN/FOS/BAX/FAS/TMBIM6/CTTN/FCGR2A/ARF1	1.71497162860331
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/278	76/9376	2.21885649375237	GADD45B/CDKN1A/MDM2/DDB2/BAX	1.86488891398301
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/278	125/9376	1.88869064748201	CTSD/TNF/ASAH1/BAX/PLD1/SGMS2/PPP2CB	1.74842233480918
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/278	77/9376	2.19004017565169	GADD45B/CDKN1A/DDB2/BAX/PLD1	1.83283737362099
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/278	34/9376	2.97587812103259	POLR2A/POLR2J3/POLR2E	2.01750560179579
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/278	204/9376	1.65326562279588	FN1/TNF/MMP2/CDKN1A/CD63/MDM2/MRAS/FAS/CTTN/FLNA	1.64895170179601
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/278	130/9376	1.81604869950194	NFKBIA/MMP2/GNAS/JUN/FOS/ACTA2/ARRB2	1.63774347765204
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/278	156/9376	1.72957019000184	NFKBIA/TNF/CDKN1A/CXCL10/TICAM1/BAX/FAS/PPP2CB	1.60619766092202
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	11/278	238/9376	1.55879330149326	NFKBIA/TNF/ISG15/CFD/CXCL10/JUN/RPS27L/C2/FOS/ADAM17/FCGR2A	1.52633253962416
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/278	59/9376	2.2865504206804	GADD45B/CDKN1A/DDB2/BAX	1.73280558528846
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/278	18/9376	3.74740207833733	TCN2/PRDX1	2.03939816631426
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/278	83/9376	2.03172401837566	NFKBIA/CCL4/CXCL10/CCL5/POLR2E	1.65028779771451
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/278	38/9376	2.66262779250284	HEXB/AMDHD2/HEXA	1.79512613301745
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/278	109/9376	1.85651112137813	HLA-DRB5/NFKBIA/HLA-DQA2/HLA-DMB/JUN/FOS	1.57221430633162
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/278	110/9376	1.83963374754742	TNF/ID2/EMP3/TGIF1/PPP2CB/CUL1	1.54837143435034
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/278	138/9376	1.71077051402356	ATP6V0C/ATP6V0B/ATP6V0E1/ATP6V0A1/ATP6V1G1/ATP6AP1/ATP6V0D2	1.47033074034856
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/278	63/9376	2.14137261619276	POLR2A/DDB2/POLR2J3/POLR2E	1.58886863484312
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/278	63/9376	2.14137261619276	GADD45B/CDKN1A/DDB2/BAX	1.58886863484312
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/278	41/9376	2.46780136866117	MMP2/CDKN1A/MDM2	1.64640670259393
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/278	168/9376	1.60602946214457	FTH1/TNF/FTL/TICAM1/SQSTM1/BAX/GLUL/FAS	1.38548169861521
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/278	90/9376	1.87370103916867	SOD2/BAX/PPARG/RHEB/ADIPOR1	1.45581046590386
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/278	90/9376	1.87370103916867	NFKBIA/JUN/TICAM1/FOS/MAP2K3	1.45581046590386
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/278	143/9376	1.65095336318358	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/C2/FCGR3A/FCGR2A	1.37113919617973
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/278	91/9376	1.85311091785912	NFKBIA/JUN/FOS/IFITM1/LILRB4	1.42945442040532
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/278	22/9376	3.06605624591236	ALDH2/HNMT	1.69585949771385
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/278	44/9376	2.29954218443427	GNAS/VAMP2/RAB11A	1.51030418145366
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/278	174/9376	1.55064913586372	PPP1R15A/SSR3/BAX/CRYAB/CUL1/BCAP31/TMEM258/VCP	1.28157356783981
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/278	23/9376	2.93274945261182	ATP6AP2/CTSA	1.62218013838168
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/278	69/9376	1.95516630174122	GNAS/JUN/FOS/FOSB	1.3919824202374
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/278	45/9376	2.2484412470024	ABCG1/TAP1/ABCA6	1.46738927617977
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/278	122/9376	1.65868616582144	PPARG/CAB39L/PPP2CB/EEF2/RHEB/ADIPOR1	1.28005544068936
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/278	122/9376	1.65868616582144	NFKBIA/TNF/MAP3K8/JUN/FOS/PPP2CB	1.28005544068936
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/278	46/9376	2.19956208945887	FTH1/FTL/BLVRB	1.42559412159416
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/278	98/9376	1.72074585229775	SCIN/NCF1/PLD1/FCGR3A/FCGR2A	1.25372727899841
NA	NA	hsa03272	Virion - Hepatitis viruses	3/278	48/9376	2.10791366906475	CD63/LAMP1/CD9	1.34513954505378
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/278	73/9376	1.84803390164581	GADD45B/CDKN1A/DDB2/BAX	1.27144683127437
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/278	154/9376	1.53302812295618	CDKN1A/GNAS/RCAN1/JUN/FOS/EEF2/CD38	1.16582400838923
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/278	49/9376	2.0648950227573	GNAS/JUN/FOSB	1.30637818243932
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/278	26/9376	2.59435528500277	PLA2G2D/PLA2G12B	1.42298736588457
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/278	128/9376	1.58093525179856	ADA2/GUK1/GMPR/PDE8A/ENPP4/NUDT2	1.1567616310299
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/278	157/9376	1.50373459194428	TNF/JUN/FOS/BAX/FAS/PPARG/ADIPOR1	1.11261462401629
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/278	158/9376	1.49421728440033	TNF/RPS6KA2/SLC3A2/RRAGD/CAB39L/ATP6V1G1/RHEB	1.09512373462125
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/278	51/9376	1.98391874735506	PLA2G2D/PLD1/PLA2G12B	1.23155829389262
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/278	105/9376	1.60602946214457	LMNA/TNF/GNAS/EMD/DTNA	1.09159155424547
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/278	133/9376	1.52150159571591	GADD45B/CDKN1A/SOD2/GABARAP/MDM2/KLF2	1.05879054773147
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/278	53/9376	1.9090538889643	GNAS/RAB11A/ATP1B1	1.16007159153525
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/278	136/9376	1.48793906051629	NFKBIA/JUN/FOS/BAX/FAS/RAB9A	1.00192248744588
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/278	30/9376	2.2484412470024	PLA2G2D/PLA2G12B	1.19715647199501
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/278	30/9376	2.2484412470024	TNF/FOLR2	1.19715647199501
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/278	227/9376	1.33717871517764	NFKBIA/SOD2/GSTO1/JUN/GSTO2/FOS/NCF1/PLD1/ABL2	0.898920606536767
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/278	140/9376	1.44542651593011	MAP1LC3B/EGR1/MRAS/KLF2/ACTA2/SERPINE1	0.928182107593742
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/278	32/9376	2.10791366906475	B4GALT1/GAA	1.09736110960757
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/278	142/9376	1.42506839598744	UBC/MDM2/UBE2B/DDB2/CUL1/ANAPC16	0.892160771260341
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/278	86/9376	1.56867993976911	GNAS/VAMP2/ATP1B1/KCNMA1	0.926071134005707
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/278	10/9376	3.3726618705036	SQOR	1.31218129982815
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/278	116/9376	1.45373356487224	CD99/MMP2/ITGB2/CXCR4/NCF1	0.859526910821056
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/278	34/9376	1.98391874735506	BHLHE40/CUL1	1.00464778842904
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/278	148/9376	1.36729535290686	GADD45B/CDKN1A/JUN/DDB2/FOS/BAX	0.787277007989681
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/278	120/9376	1.4052757793765	NFKBIA/JUN/RIPK2/RPS6KA2/BAX	0.781024521770477
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/278	63/9376	1.60602946214457	LTA4H/PLA2G2D/PLA2G12B	0.843634401712101
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/278	37/9376	1.82306047054249	TNF/FAS	0.876834215596721
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/278	65/9376	1.55661317100166	GNAS/PDE8A/NR4A1	0.787131084910704
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/278	38/9376	1.77508519500189	ATP1B1/NR3C2	0.836853380616425
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/278	217/9376	1.24337764811193	GNAS/GSTO1/JUN/GSTO2/RPS6KA2/KLF4/FOS/ARRB2	0.63404721209414
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/278	157/9376	1.28891536452367	TIMD4/LIPA/ADAM17/PPARG/BSG/SIRPA	0.638136560031174
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/278	158/9376	1.28075767234314	GADD45B/CDKN1A/MDM2/PPP2CB/CUL1/ANAPC16	0.622123912628953
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/278	69/9376	1.46637472630591	GNAS/CTSB/KCNMA1	0.679656955105545
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/278	99/9376	1.36269166484994	JUN/FOS/PLD1/RHEB	0.634141921052334
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/278	99/9376	1.36269166484994	LMNA/TNF/EMD/DTNA	0.634141921052334
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/278	70/9376	1.44542651593011	NFKBIA/TNF/ADIPOR1	0.65385075949162
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/278	70/9376	1.44542651593011	GSTO1/GSTO2/SULT1A1	0.65385075949162
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/278	226/9376	1.19386260902782	NFKBIA/GNAS/JUN/CNGA1/ATP1B1/FOS/PLD1/SUCNR1	0.515671103522572
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/278	134/9376	1.2584559218297	GNAS/PLA2G2D/ACTA2/KCNMA1/PLA2G12B	0.526733541436775
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/278	43/9376	1.56867993976911	PLA2G2D/PLA2G12B	0.653320932897604
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/278	104/9376	1.29717764250138	PLA2G2D/PLD1/SGMS2/PLA2G12B	0.53269811650204
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/278	106/9376	1.27270259264287	NFKBIA/CDKN1A/FOLR2/MDM2	0.493557098398734
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/278	138/9376	1.22197893858826	CPEB4/RPS6KA2/PPP2CB/CUL1/ANAPC16	0.459195268622866
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/278	170/9376	1.19035124841303	GADD45B/CDKN1A/GSTO1/DDB2/GSTO2/BAX	0.437804050004906
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/278	139/9376	1.21318772320273	CTSD/MMP2/GNAS/JUN/FOS	0.442628312260897
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/278	17/9376	1.98391874735506	CYP27A1	0.709747779630612
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/278	17/9376	1.98391874735506	GLUL	0.709747779630612
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/278	17/9376	1.98391874735506	LAMP1	0.709747779630612
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/278	109/9376	1.23767408091875	NFKBIA/TNF/RPS6KA2/OGA	0.436275234422451
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/278	79/9376	1.28075767234314	GSTO1/DHDH/GSTO2	0.438035020419479
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/278	19/9376	1.77508519500189	OGDH	0.59114360685496
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/278	50/9376	1.34906474820144	SAT1/ALDH2	0.432591875259064
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/278	50/9376	1.34906474820144	TNF/ITGB2	0.432591875259064
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/278	82/9376	1.23390068433058	GSTO1/GSTO2/CES1	0.371853740527072
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/278	20/9376	1.6863309352518	LIPA	0.537079450151628
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/278	149/9376	1.13176572835691	GNAS/MRAS/PLD1/RHEB/ARF1	0.283400368630196
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/278	85/9376	1.19035124841303	ADA2/GUK1/GMPR	0.308154867587044
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/278	21/9376	1.60602946214457	ALDH2	0.485977943922465
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/278	86/9376	1.17650995482684	CDKN1A/JUN/ABL2	0.287438966277146
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/278	86/9376	1.17650995482684	LMNA/EMD/DTNA	0.287438966277146
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/278	122/9376	1.10579077721429	RCAN1/MDM2/ATP1B1/RHEB	0.205588134341693
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/278	122/9376	1.10579077721429	GNAS/JUNB/FOS/MAP2K3	0.205588134341693
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/278	56/9376	1.20452209660843	B4GALT1/TMEM258	0.268325139228631
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/278	56/9376	1.20452209660843	CUL1/ARRB2	0.268325139228631
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/278	23/9376	1.46637472630591	GLUL	0.391433983869087
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/278	23/9376	1.46637472630591	B4GALT1	0.391433983869087
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/278	23/9376	1.46637472630591	ATP1B1	0.391433983869087
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/278	91/9376	1.11186655071547	GNAS/PDE8A/ARRB2	0.187441201452463
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/278	59/9376	1.1432752103402	GSTO1/GSTO2	0.192971904342143
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/278	60/9376	1.1242206235012	GNAS/PPP2CB	0.168728971770462
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/278	233/9376	1.0132460555161	FN1/VIM/LMNA/ATP1B1/EMD/DTNA/SDC3	0.035789467890265
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/278	26/9376	1.29717764250138	TCN2	0.265235756848322
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/278	62/9376	1.08795544209793	SOD2/CRYAB	0.121457828913442
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/278	62/9376	1.08795544209793	ADAM17/TLE1	0.121457828913442
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/278	133/9376	1.01433439714394	GNAS/FOS/PPP2CB/ARRB2	0.0291027378019748
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/278	98/9376	1.03244751137865	GNAS/ATP1B1/NR4A1	0.056441989948798
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/278	28/9376	1.20452209660843	B4GALT1	0.189450157151472
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/278	170/9376	0.991959373677529	RAPGEF2/JUN/CTTN/YBX3/PPP2CB	-0.0184932791242623
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/278	29/9376	1.16298685189779	CNGA1	0.153656352233524
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/278	30/9376	1.1242206235012	OGDH	0.119117758834694
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/278	68/9376	0.991959373677529	ALDH1A1/DHRS9	-0.0116319149558173
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/278	31/9376	1.08795544209793	ALDH2	0.085741085970536
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/278	31/9376	1.08795544209793	ALDH2	0.085741085970536
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/278	31/9376	1.08795544209793	GLUL	0.085741085970536
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/278	31/9376	1.08795544209793	SRP14	0.085741085970536
NA	NA	hsa04981	Folate transport and metabolism	1/278	31/9376	1.08795544209793	FOLR2	0.085741085970536
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/278	69/9376	0.977583150870608	TNF/MAP2K3	-0.0326685100263115
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/278	32/9376	1.05395683453237	BAX	0.0534429111821869
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/278	70/9376	0.963617677286742	CDKN1A/JUN	-0.0534063610659976
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/278	71/9376	0.950045597324957	IRF1/FOS	-0.0738549869677242
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/278	33/9376	1.02201874863745	OGDH	0.0221483561826128
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/278	110/9376	0.919816873773708	CPEB4/RPS6KA2/ANAPC16	-0.147865974335061
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/278	73/9376	0.924016950822903	GSTO1/GSTO2	-0.113920454028186
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/278	150/9376	0.899376498800959	GADD45B/CDKN1A/DDB2/BAX	-0.217156782768698
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/278	75/9376	0.899376498800959	GNAS/ATP1B1	-0.152932681681338
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/278	36/9376	0.936850519584333	DHDH	-0.0663563766754472
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/278	36/9376	0.936850519584333	GAA	-0.0663563766754472
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/278	36/9376	0.936850519584333	ST3GAL1	-0.0663563766754472
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/278	76/9376	0.887542597500947	GNAS/ATP1B1	-0.172063376033847
NA	NA	hsa04517	IgSF CAM signaling	8/278	299/9376	0.902384446957484	ITGB2/RAPGEF2/SLAMF7/MBP/LY9/CD84/NPHS1/CRTAM	-0.299859985376466
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/278	37/9376	0.911530235271243	GLUL	-0.0942498389077507
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/278	116/9376	0.872240138923344	GNAS/GLUL/PLD1	-0.242020972702484
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/278	154/9376	0.876016070260675	GNAS/ATP1B1/KCNE1/PPP2CB	-0.271174138322964
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/278	78/9376	0.864785095000922	PABPC4/BTG1	-0.20961008191459
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/278	78/9376	0.864785095000922	FN1/CTTN	-0.20961008191459
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/278	155/9376	0.870364353678348	CDKN1A/GNAS/PDE8A/NR4A1	-0.284469916484
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/278	38/9376	0.887542597500947	CD38	-0.121419371784601
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/278	38/9376	0.887542597500947	TAP1	-0.121419371784601
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/278	157/9376	0.859276909682445	ITGB2/ID2/SERPINE1/PPP2CB	-0.310819567939054
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/278	232/9376	0.872240138923344	FN1/ITGB2/CXCR4/SCIN/MRAS/IQGAP2	-0.344433499788356
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/278	308/9376	0.876016070260675	SOD2/POLR2A/WIPI1/POLR2J3/BAX/PSMA6/PPARG/POLR2E	-0.386740870003645
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/278	83/9376	0.812689607350264	SOD2/PRDX1	-0.299611184647656
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/278	42/9376	0.803014731072285	ALDH2	-0.223645192277364
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/278	43/9376	0.784339969884557	ALDH2	-0.247758364961757
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/278	44/9376	0.76651406147809	POLG2	-0.271353091484124
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/278	89/9376	0.757901543933393	GABARAP/GLUL	-0.401129285809484
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/278	46/9376	0.733187363152956	PSMA6	-0.317087818962142
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/278	90/9376	0.749480415667466	GNAS/ATP1B1	-0.417430009162186
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/278	47/9376	0.717587632022042	ALDH2	-0.339273676227116
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/278	47/9376	0.717587632022042	TNF	-0.339273676227116
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/278	212/9376	0.795439120401792	ITGB2/GNAS/RAPGEF2/MRAS/MAP2K3	-0.526602652813463
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/278	48/9376	0.702637889688249	ALDH2	-0.361033124646469
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/278	48/9376	0.702637889688249	ATP1B1	-0.361033124646469
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/278	368/9376	0.824835783547075	TNF/MAP1LC3B/WIPI1/SQSTM1/BAX/PSMA6/PINK1/MAP2K3/VCP	-0.599225354811304
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/278	49/9376	0.688298340919101	B4GALT1	-0.382385341419918
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/278	178/9376	0.757901543933393	JUN/FOSL1/TLE1/CUL1	-0.57002038649209
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/278	97/9376	0.695394200103834	GNAS/FOS	-0.527118814758206
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/278	52/9376	0.648588821250692	GNAS	-0.444172004393149
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/278	99/9376	0.681345832424969	GNAS/MAP2K3	-0.557145326350327
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/278	101/9376	0.667853835743286	GNAS/MITF	-0.586635092727309
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/278	268/9376	0.75507355309782	UBC/GNAS/BAX/PSMA6/PINK1/DUSP1	-0.711093384467411
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/278	103/9376	0.654885800097786	PABPC4/PPP2CB	-0.61561101405495
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/278	103/9376	0.654885800097786	ATP1B1/SLC3A2	-0.61561101405495
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	6/278	275/9376	0.735853499018967	TNF/EGR1/CCL5/NCF1/BAX/PSMA6	-0.77714439988081
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/278	107/9376	0.630404087944598	GNAS/PHKG1	-0.672105851843553
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/278	59/9376	0.571637605170101	NUDT2	-0.576944936131019
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/278	59/9376	0.571637605170101	GNAS	-0.576944936131019
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/278	235/9376	0.717587632022042	GNAS/RPS6KA2/PPARG/MAP2K3/RHEB	-0.766400640254033
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/278	195/9376	0.691828076000738	ITGB2/NCF1/FCGR3A/FCGR2A	-0.760152016092597
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/278	238/9376	0.708542409769663	PLA2G2D/MRAS/PLD1/PLA2G12B/ABL2	-0.79611048074522
NA	NA	hsa04518	Integrin signaling	3/278	154/9376	0.657012052695506	FN1/ITGB2/FLNA	-0.750173520560362
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/278	110/9376	0.613211249182472	CDKN1A/SERPINE1	-0.71327844389686
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/278	480/9376	0.772901678657074	UBC/TNF/MAP1LC3B/WIPI1/SQSTM1/BAX/FAS/PSMA6/PINK1/MAP2K3/VCP	-0.892837094515865
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/278	63/9376	0.53534315404819	ALDH2	-0.646834064549941
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/278	203/9376	0.664563915370167	FN1/EMP1/JUN/FLNA	-0.84457295880624
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/278	65/9376	0.518871057000553	ALDH2	-0.680385529152283
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/278	65/9376	0.518871057000553	ARRB2	-0.680385529152283
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/278	115/9376	0.586549890522365	GNAS/DUSP1	-0.779790893709637
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/278	66/9376	0.511009374318727	DHRS9	-0.696839452151939
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/278	67/9376	0.50338236873188	ALDH2	-0.713087937808458
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/278	67/9376	0.50338236873188	RPS6KA2	-0.713087937808458
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/278	68/9376	0.495979686838764	CD14	-0.729137405914657
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/278	166/9376	0.609517205512698	CNGA1/ATP1B1/KCNMA1	-0.887281040384362
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/278	254/9376	0.663909817028267	GNAS/CXCR4/P2RX7/CD38/PHKG1	-0.949210910322207
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/278	73/9376	0.462008475411452	CXCR4	-0.806604096679463
NA	NA	hsa04382	Cornified envelope formation	4/278	217/9376	0.621688824055963	S100A10/S100A6/S100A4/PPP2CB	-0.985575907533883
Organismal Systems	Immune system	hsa04611	Platelet activation	2/278	126/9376	0.53534315404819	GNAS/FCGR2A	-0.917871354310525
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/278	75/9376	0.44968824940048	GLUL	-0.83639160610661
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/278	80/9376	0.42158273381295	BAX	-0.908182761949307
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/278	138/9376	0.488791575435304	RHEB/PHKG1	-1.05750793896567
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/278	191/9376	0.529737466571246	GNAS/SLC29A1/FOSB	-1.14776387728549
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/278	87/9376	0.387662283965931	ATP1B1	-1.00300067378554
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/278	144/9376	0.468425259792166	ID2/KLF4	-1.12365439204494
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/278	144/9376	0.468425259792166	WIPI1/PSMA6	-1.12365439204494
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/278	89/9376	0.378950771966696	FN1	-1.02900711281278
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/278	89/9376	0.378950771966696	GNAS	-1.02900711281278
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/278	93/9376	0.362651814032645	PTPRM	-1.07971497050814
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/278	205/9376	0.493560273732234	CTSD/MMP2/NCF1	-1.28153779562459
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/278	388/9376	0.608469925090855	TNF/RTN4/APOE/WIPI1/ADAM17/FAS/PSMA6	-1.3768433404641
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/278	362/9376	0.559004729917723	FN1/CDKN1A/MDM2/PPP2CB/RHEB/NR4A1	-1.49576893656827
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/278	108/9376	0.312283506528111	EEF1A1	-1.25650255266742
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/278	168/9376	0.401507365536142	CDKN1A/IL10RA	-1.36825128743967
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/278	115/9376	0.293274945261182	FOS	-1.33292445547553
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/278	116/9376	0.290746712974448	OGDH	-1.34356885622603
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/278	184/9376	0.366593681576478	CXCR4/SEMA4A	-1.51677570894894
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/278	194/9376	0.347697100051917	DYNLT1/ACTA2	-1.60478405260195
NA	NA	hsa04082	Neuroactive ligand signaling	2/278	199/9376	0.338960992010412	GNAS/OGFR	-1.64754896358103
NA	NA	hsa04081	Hormone signaling	2/278	219/9376	0.308005650274301	GNAS/ADIPOR1	-1.81126947714107
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/278	154/9376	0.219004017565169	ALDH2	-1.70817228503516
Genetic Information Processing	Translation	hsa03010	Ribosome	2/278	222/9376	0.303843411757081	RPS27L/MRPL23	-1.83490270386521
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/278	183/9376	0.184298462869049	NOP10	-1.9478847854847
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/278	323/9376	0.313250328529746	VIM/CDKN1A/MDM2	-2.19552573067184
NA	NA	hsa04519	Cadherin signaling	4/278	404/9376	0.333926917871643	NFKBIA/VIM/MRAS/MAP2K3	-2.3922303887652
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/278	370/9376	0.273459070581373	P2RX7/TSPO/OGFR	-2.49247060857588
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/278	449/9376	0.0751149637083206	ARRB2	-3.51069601326409