ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0008009 chemokine activity 11/430 45/18639 0.244444444444444 10.5958139534884 4.34669901448596e-09 3.4034653283425e-06 GO:0042605 peptide antigen binding 10/430 45/18639 0.222222222222222 9.63255813953488 5.96300675633708e-08 2.33451714510597e-05 GO:0043394 proteoglycan binding 9/430 37/18639 0.243243243243243 10.543746071653 1.19450000444283e-07 3.07885765857536e-05 GO:0031625 ubiquitin protein ligase binding 24/430 302/18639 0.0794701986754967 3.44475589095949 1.57285193286097e-07 3.07885765857536e-05 GO:0042277 peptide binding 21/430 249/18639 0.0843373493975904 3.6557298963295 3.54832493404504e-07 5.55667684671453e-05 GO:0044389 ubiquitin-like protein ligase binding 24/430 322/18639 0.0745341614906832 3.2307958977322 5.09178973620445e-07 6.64478560574681e-05 GO:0042379 chemokine receptor binding 11/430 72/18639 0.152777777777778 6.62238372093023 7.39545524646795e-07 8.27234493997772e-05 GO:0023023 MHC protein complex binding 8/430 37/18639 0.216216216216216 9.37221873035826 1.6138942502419e-06 0.000157959899742426 GO:0042288 MHC class I protein binding 6/430 20/18639 0.3 13.0039534883721 4.28870121378446e-06 0.000373117005599248 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/430 24/18639 0.25 10.8366279069767 1.37708203906364e-05 0.000898546030489026 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/430 24/18639 0.25 10.8366279069767 1.37708203906364e-05 0.000898546030489026 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/430 24/18639 0.25 10.8366279069767 1.37708203906364e-05 0.000898546030489026 GO:0001664 G protein-coupled receptor binding 20/430 297/18639 0.0673400673400673 2.91895701198027 2.03477961015475e-05 0.00117052964505492 GO:0061134 peptidase regulator activity 17/430 226/18639 0.0752212389380531 3.26057830829389 2.09290102564098e-05 0.00117052964505492 GO:0042287 MHC protein binding 7/430 41/18639 0.170731707317073 7.40062393647192 3.77976910618003e-05 0.00197303947342598 GO:0042056 chemoattractant activity 7/430 42/18639 0.166666666666667 7.22441860465116 4.44652335995507e-05 0.00217601736927801 GO:0003823 antigen binding 14/430 174/18639 0.0804597701149425 3.48765036086608 5.35824714972753e-05 0.00246794559896274 GO:0002020 protease binding 12/430 136/18639 0.0882352941176471 3.82469220246238 7.50271191002342e-05 0.00311645477021502 GO:0005126 cytokine receptor binding 18/430 275/18639 0.0654545454545455 2.83722621564482 7.56227849732892e-05 0.00311645477021502 GO:0042626 ATPase-coupled transmembrane transporter activity 10/430 98/18639 0.102040816326531 4.42311343141908 8.82105157749278e-05 0.00345344169258842 GO:0005543 phospholipid binding 26/430 497/18639 0.0523138832997988 2.2676243507557 9.74118343860184e-05 0.0036320698249644 GO:0038187 pattern recognition receptor activity 7/430 48/18639 0.145833333333333 6.32136627906977 0.000107735370414444 0.00383439977429588 GO:0070008 serine-type exopeptidase activity 4/430 12/18639 0.333333333333333 14.4488372093023 0.000119368956088897 0.00406373446163507 GO:0050699 WW domain binding 5/430 24/18639 0.208333333333333 9.03052325581395 0.000188869867183365 0.00608693758420478 GO:0004197 cysteine-type endopeptidase activity 9/430 88/18639 0.102272727272727 4.43316596194503 0.000194346666162349 0.00608693758420478 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/430 54/18639 0.12962962962963 5.61899224806201 0.00023011000105454 0.00671771094785601 GO:0120020 cholesterol transfer activity 5/430 25/18639 0.2 8.6693023255814 0.000231645205098483 0.00671771094785601 GO:0023026 MHC class II protein complex binding 5/430 27/18639 0.185185185185185 8.02713178294574 0.000338870418910278 0.00947626921452671 GO:0005125 cytokine activity 15/430 234/18639 0.0641025641025641 2.77862254025045 0.000368886611205487 0.00995993850254815 GO:0008429 phosphatidylethanolamine binding 4/430 17/18639 0.235294117647059 10.1991792065663 0.000523703335317061 0.0136686570517753 GO:0001968 fibronectin binding 5/430 30/18639 0.166666666666667 7.22441860465116 0.000565118933145355 0.0142738104726714 GO:0008236 serine-type peptidase activity 13/430 194/18639 0.0670103092783505 2.90466315032366 0.000590239264233744 0.0144424169967194 GO:0004857 enzyme inhibitor activity 21/430 416/18639 0.0504807692307692 2.18816525044723 0.000712859724450398 0.0164567161728053 GO:0017171 serine hydrolase activity 13/430 198/18639 0.0656565656565657 2.84598308668076 0.000714595593710574 0.0164567161728053 GO:0120015 sterol transfer activity 5/430 32/18639 0.15625 6.77289244186047 0.000768912253794877 0.0172016655634683 GO:0097001 ceramide binding 4/430 19/18639 0.210526315789474 9.12558139534884 0.000822289053314814 0.0178847869095972 GO:0140311 protein sequestering activity 5/430 33/18639 0.151515151515152 6.5676532769556 0.00088924420499477 0.0188183300678623 GO:0048020 CCR chemokine receptor binding 6/430 50/18639 0.12 5.20158139534884 0.000980290788916901 0.020199149676893 GO:0061135 endopeptidase regulator activity 12/430 184/18639 0.0652173913043478 2.82694641051567 0.00119962419570305 0.0240847626983459 GO:0004175 endopeptidase activity 20/430 405/18639 0.0493827160493827 2.1405684754522 0.00123571571701021 0.0241891351604748 GO:0004866 endopeptidase inhibitor activity 11/430 161/18639 0.0683229813664596 2.96156290625451 0.00130709150668164 0.0249622597495543 GO:0140313 molecular sequestering activity 6/430 55/18639 0.109090909090909 4.72871035940803 0.00162364106886569 0.030269308498139 GO:0008199 ferric iron binding 3/430 11/18639 0.272727272727273 11.8217758985201 0.00175255781242048 0.031912855049424 GO:0030414 peptidase inhibitor activity 11/430 169/18639 0.0650887573964497 2.82137057933122 0.0019251998685626 0.0340253911664386 GO:0016504 peptidase activator activity 6/430 57/18639 0.105263157894737 4.56279069767442 0.00195548225094475 0.0340253911664386 GO:0061791 GTPase motor activity 5/430 40/18639 0.125 5.41831395348837 0.00216044324169271 0.0359920650690508 GO:1990606 membrane scission GTPase motor activity 5/430 40/18639 0.125 5.41831395348837 0.00216044324169271 0.0359920650690508 GO:0004859 phospholipase inhibitor activity 3/430 12/18639 0.25 10.8366279069767 0.00229695409786433 0.0374690637214119 GO:0001530 lipopolysaccharide binding 5/430 41/18639 0.121951219512195 5.2861599546228 0.0024146357067577 0.0385848930283934 GO:0008238 exopeptidase activity 8/430 102/18639 0.0784313725490196 3.39972640218878 0.00249228593655966 0.0390291977665243 GO:0008198 ferrous iron binding 4/430 26/18639 0.153846153846154 6.66869409660107 0.00279218917660676 0.0428683161820214 GO:0140375 immune receptor activity 10/430 156/18639 0.0641025641025641 2.77862254025045 0.00339747982039607 0.0511582057571177 GO:0005545 1-phosphatidylinositol binding 3/430 14/18639 0.214285714285714 9.28853820598007 0.00367231519743468 0.0525017738216904 GO:0044548 S100 protein binding 3/430 14/18639 0.214285714285714 9.28853820598007 0.00367231519743468 0.0525017738216904 GO:0046625 sphingolipid binding 4/430 28/18639 0.142857142857143 6.19235880398671 0.00368786406154913 0.0525017738216904 GO:0038024 cargo receptor activity 6/430 65/18639 0.0923076923076923 4.00121645796064 0.00381579924350047 0.0533530501368012 GO:0008234 cysteine-type peptidase activity 11/430 187/18639 0.0588235294117647 2.54979480164159 0.00419930108876439 0.0576851360088161 GO:0015929 hexosaminidase activity 3/430 15/18639 0.2 8.6693023255814 0.00451250544294705 0.0609188234797852 GO:0140297 DNA-binding transcription factor binding 21/430 488/18639 0.0430327868852459 1.86532119710255 0.00484759632859887 0.0643333546659816 GO:0015399 primary active transmembrane transporter activity 10/430 166/18639 0.0602409638554217 2.61123564023536 0.005263813031513 0.0686927600612447 GO:0055102 lipase inhibitor activity 3/430 16/18639 0.1875 8.12747093023256 0.00545972874647531 0.0700814362047568 GO:0005518 collagen binding 6/430 72/18639 0.0833333333333333 3.61220930232558 0.00631098678375597 0.0797016556722729 GO:0004867 serine-type endopeptidase inhibitor activity 7/430 95/18639 0.0736842105263158 3.19395348837209 0.00641951698977 0.0797369087161528 GO:0045236 CXCR chemokine receptor binding 3/430 17/18639 0.176470588235294 7.64938440492476 0.00651744847743778 0.0797369087161528 GO:0031690 adrenergic receptor binding 3/430 18/18639 0.166666666666667 7.22441860465116 0.00768871034899709 0.0926193877425342 GO:0004252 serine-type endopeptidase activity 10/430 176/18639 0.0568181818181818 2.46286997885835 0.00785166827836577 0.0931493373024302 GO:0140036 ubiquitin-modified protein reader activity 3/430 19/18639 0.157894736842105 6.84418604651163 0.00897616434193752 0.104900547458762 GO:0046332 SMAD binding 6/430 79/18639 0.0759493670886076 3.2921401236385 0.00982193052029351 0.113096641138086 GO:0003924 GTPase activity 15/430 331/18639 0.0453172205438066 1.96434342724654 0.0103004554713434 0.114888350814227 GO:0016004 phospholipase activator activity 3/430 20/18639 0.15 6.50197674418605 0.0103820857401107 0.114888350814227 GO:0048306 calcium-dependent protein binding 6/430 80/18639 0.075 3.25098837209302 0.0104177176344957 0.114888350814227 GO:0016298 lipase activity 8/430 130/18639 0.0615384615384615 2.66747763864043 0.010616055029672 0.115449598447683 GO:0045296 cadherin binding 15/430 334/18639 0.0449101796407186 1.9466996240078 0.0111199579067634 0.119272973164326 GO:0019001 guanyl nucleotide binding 17/430 400/18639 0.0425 1.84222674418605 0.0119358463031931 0.124610235405335 GO:0032561 guanyl ribonucleotide binding 17/430 400/18639 0.0425 1.84222674418605 0.0119358463031931 0.124610235405335 GO:0008135 translation factor activity, RNA binding 6/430 83/18639 0.072289156626506 3.13348276828243 0.0123584049629421 0.127324093236627 GO:0005178 integrin binding 9/430 161/18639 0.0559006211180124 2.42309692329915 0.0125558741809897 0.127678564723571 GO:0180051 translation factor activity 6/430 84/18639 0.0714285714285714 3.09617940199336 0.0130581608205022 0.131083845159657 GO:0004177 aminopeptidase activity 4/430 40/18639 0.1 4.3346511627907 0.0132583907950821 0.131409113829737 GO:0140035 ubiquitin-like protein reader activity 3/430 22/18639 0.136363636363636 5.91088794926004 0.0135566786473236 0.13268599226068 GO:0016209 antioxidant activity 6/430 86/18639 0.0697674418604651 3.02417522985398 0.0145400321423607 0.14055364404282 GO:0005525 GTP binding 16/430 378/18639 0.0423280423280423 1.83477297895903 0.0149731751858596 0.142975563055221 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 15/430 349/18639 0.0429799426934097 1.86303058572666 0.0160135178819665 0.151067283151563 GO:0120013 lipid transfer activity 5/430 65/18639 0.0769230769230769 3.33434704830054 0.0170025104787607 0.156817999558409 GO:0060229 lipase activator activity 3/430 24/18639 0.125 5.41831395348837 0.0172239437573731 0.156817999558409 GO:0070300 phosphatidic acid binding 3/430 24/18639 0.125 5.41831395348837 0.0172239437573731 0.156817999558409 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 19/430 484/18639 0.0392561983471074 1.70161925812032 0.017600119984331 0.158401079858979 GO:0030547 signaling receptor inhibitor activity 4/430 44/18639 0.0909090909090909 3.94059196617336 0.0183329829162292 0.163121882084176 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/430 91/18639 0.0659340659340659 2.85801175568617 0.0187478616575115 0.164939052559905 GO:0022853 active monoatomic ion transmembrane transporter activity 7/430 118/18639 0.0593220338983051 2.57140323216397 0.0196124431926802 0.170628255776318 GO:0001216 DNA-binding transcription activator activity 19/430 491/18639 0.0386965376782077 1.67735992042817 0.0200995668326132 0.172668036843313 GO:1990841 promoter-specific chromatin binding 5/430 68/18639 0.0735294117647059 3.18724350205198 0.0202987861018585 0.172668036843313 GO:0005031 tumor necrosis factor receptor activity 2/430 10/18639 0.2 8.6693023255814 0.0211385234129374 0.172668036843313 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/430 10/18639 0.2 8.6693023255814 0.0211385234129374 0.172668036843313 GO:0043422 protein kinase B binding 2/430 10/18639 0.2 8.6693023255814 0.0211385234129374 0.172668036843313 GO:0019865 immunoglobulin binding 3/430 26/18639 0.115384615384615 5.00152057245081 0.0213905486255445 0.172668036843313 GO:0070412 R-SMAD binding 3/430 26/18639 0.115384615384615 5.00152057245081 0.0213905486255445 0.172668036843313 GO:0005044 scavenger receptor activity 3/430 27/18639 0.111111111111111 4.81627906976744 0.0236620105401901 0.187144992454231 GO:0035255 ionotropic glutamate receptor binding 3/430 27/18639 0.111111111111111 4.81627906976744 0.0236620105401901 0.187144992454231 GO:0001851 complement component C3b binding 2/430 11/18639 0.181818181818182 7.88118393234672 0.0254465157686079 0.191582902373269 GO:0008432 JUN kinase binding 2/430 11/18639 0.181818181818182 7.88118393234672 0.0254465157686079 0.191582902373269 GO:0019864 IgG binding 2/430 11/18639 0.181818181818182 7.88118393234672 0.0254465157686079 0.191582902373269 GO:0042608 T cell receptor binding 2/430 11/18639 0.181818181818182 7.88118393234672 0.0254465157686079 0.191582902373269 GO:0050786 RAGE receptor binding 2/430 11/18639 0.181818181818182 7.88118393234672 0.0254465157686079 0.191582902373269 GO:1901681 sulfur compound binding 12/430 275/18639 0.0436363636363636 1.89148414376321 0.0264530750216349 0.197264359447049 GO:0043236 laminin binding 3/430 29/18639 0.103448275862069 4.4841218925421 0.0285809591696251 0.206881142305989 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/430 29/18639 0.103448275862069 4.4841218925421 0.0285809591696251 0.206881142305989 GO:0051861 glycolipid binding 3/430 29/18639 0.103448275862069 4.4841218925421 0.0285809591696251 0.206881142305989 GO:0033218 amide binding 11/430 247/18639 0.0445344129554656 1.9304114490161 0.0287995459915105 0.206881142305989 GO:0019003 GDP binding 5/430 75/18639 0.0666666666666667 2.88976744186047 0.0295391771836866 0.210265233952969 GO:0016798 hydrolase activity, acting on glycosyl bonds 7/430 130/18639 0.0538461538461538 2.33404293381038 0.031198873879997 0.218314904675428 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/430 30/18639 0.1 4.3346511627907 0.0312276747428454 0.218314904675428 GO:0005035 death receptor activity 2/430 13/18639 0.153846153846154 6.66869409660107 0.0350111870051811 0.242599640929706 GO:0003925 G protein activity 4/430 54/18639 0.0740740740740741 3.21085271317829 0.0357486764838409 0.2434018581465 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/430 54/18639 0.0740740740740741 3.21085271317829 0.0357486764838409 0.2434018581465 GO:0051059 NF-kappaB binding 3/430 32/18639 0.09375 4.06373546511628 0.0368921880184078 0.244801552698418 GO:0071813 lipoprotein particle binding 3/430 32/18639 0.09375 4.06373546511628 0.0368921880184078 0.244801552698418 GO:0071814 protein-lipid complex binding 3/430 32/18639 0.09375 4.06373546511628 0.0368921880184078 0.244801552698418 GO:0044325 transmembrane transporter binding 7/430 136/18639 0.0514705882352941 2.23107045143639 0.0384250215718618 0.252830183956032 GO:0001618 virus receptor activity 5/430 81/18639 0.0617283950617284 2.67571059431525 0.0392783300986731 0.256291103893842 GO:0019763 immunoglobulin receptor activity 2/430 14/18639 0.142857142857143 6.19235880398671 0.0402343323064722 0.258214431655257 GO:0019992 diacylglycerol binding 2/430 14/18639 0.142857142857143 6.19235880398671 0.0402343323064722 0.258214431655257 GO:0004620 phospholipase activity 6/430 109/18639 0.055045871559633 2.38604651162791 0.0405624202983354 0.258214431655257 GO:0140272 exogenous protein binding 5/430 82/18639 0.0609756097560976 2.6430799773114 0.0410700771399817 0.259337664521014 GO:0001540 amyloid-beta binding 5/430 83/18639 0.0602409638554217 2.61123564023536 0.0429105689462022 0.268791803879011 GO:0031386 protein tag activity 2/430 15/18639 0.133333333333333 5.77953488372093 0.0457299979777837 0.277357490228764 GO:0050780 dopamine receptor binding 2/430 15/18639 0.133333333333333 5.77953488372093 0.0457299979777837 0.277357490228764 GO:0120283 protein serine/threonine kinase binding 2/430 15/18639 0.133333333333333 5.77953488372093 0.0457299979777837 0.277357490228764 GO:0141047 molecular tag activity 2/430 15/18639 0.133333333333333 5.77953488372093 0.0457299979777837 0.277357490228764 GO:0004623 phospholipase A2 activity 3/430 35/18639 0.0857142857142857 3.71541528239203 0.0463012405161212 0.277357490228764 GO:0008201 heparin binding 8/430 172/18639 0.0465116279069767 2.01611681990265 0.0464033604341865 0.277357490228764 GO:0001786 phosphatidylserine binding 4/430 59/18639 0.0677966101694915 2.93874655104454 0.0470976892632791 0.278582372995377 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 11/430 268/18639 0.041044776119403 1.77914786532454 0.0473198666773757 0.278582372995377 GO:0005319 lipid transporter activity 8/430 178/18639 0.0449438202247191 1.94815782597335 0.0546783565319137 0.317962749238447 GO:0005539 glycosaminoglycan binding 10/430 242/18639 0.0413223140495868 1.79117816644244 0.0548211636618012 0.317962749238447 GO:0019209 kinase activator activity 7/430 148/18639 0.0472972972972973 2.05017284726587 0.0559684292348067 0.319187930098225 GO:0043531 ADP binding 3/430 38/18639 0.0789473684210526 3.42209302325581 0.0567723015687741 0.319187930098225 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/430 17/18639 0.117647058823529 5.09958960328317 0.0574782862628988 0.319187930098225 GO:0008484 sulfuric ester hydrolase activity 2/430 17/18639 0.117647058823529 5.09958960328317 0.0574782862628988 0.319187930098225 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/430 17/18639 0.117647058823529 5.09958960328317 0.0574782862628988 0.319187930098225 GO:0030169 low-density lipoprotein particle binding 2/430 17/18639 0.117647058823529 5.09958960328317 0.0574782862628988 0.319187930098225 GO:0001217 DNA-binding transcription repressor activity 11/430 278/18639 0.039568345323741 1.71514974067258 0.0584911147581962 0.3225249496878 GO:0072341 modified amino acid binding 5/430 91/18639 0.0549450549450549 2.38167646307181 0.0594022615434679 0.325258536982765 GO:0030246 carbohydrate binding 11/430 280/18639 0.0392857142857143 1.70289867109635 0.060917976392267 0.331241496632952 GO:0003746 translation elongation factor activity 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0004706 JUN kinase kinase kinase activity 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0008525 phosphatidylcholine transporter activity 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0032393 MHC class I receptor activity 2/430 18/18639 0.111111111111111 4.81627906976744 0.0637019832521366 0.331335774642092 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/430 40/18639 0.075 3.25098837209302 0.0643206101476347 0.331335774642092 GO:0050997 quaternary ammonium group binding 3/430 40/18639 0.075 3.25098837209302 0.0643206101476347 0.331335774642092 GO:0035091 phosphatidylinositol binding 11/430 284/18639 0.0387323943661972 1.67891418277104 0.0659680698879123 0.337595818753172 GO:0042562 hormone binding 5/430 94/18639 0.0531914893617021 2.30566551212271 0.066398155923357 0.337595818753172 GO:0050840 extracellular matrix binding 4/430 67/18639 0.0597014925373134 2.58785144047206 0.0689254648272016 0.348184767481928 GO:0043395 heparan sulfate proteoglycan binding 2/430 19/18639 0.105263157894737 4.56279069767442 0.0701403148886306 0.349808067247119 GO:0050145 nucleoside monophosphate kinase activity 2/430 19/18639 0.105263157894737 4.56279069767442 0.0701403148886306 0.349808067247119 GO:0048487 beta-tubulin binding 3/430 42/18639 0.0714285714285714 3.09617940199336 0.072304882318781 0.358321030731681 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/430 43/18639 0.0697674418604651 3.02417522985398 0.0764552220582767 0.371103904282216 GO:0048156 tau protein binding 3/430 43/18639 0.0697674418604651 3.02417522985398 0.0764552220582767 0.371103904282216 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/430 20/18639 0.1 4.3346511627907 0.0767801181273549 0.371103904282216 GO:0016505 peptidase activator activity involved in apoptotic process 2/430 20/18639 0.1 4.3346511627907 0.0767801181273549 0.371103904282216 GO:0001846 opsonin binding 2/430 21/18639 0.0952380952380952 4.12823920265781 0.083608720529295 0.401629620702073 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/430 46/18639 0.0652173913043478 2.82694641051567 0.0895120297456694 0.42485450930417 GO:0008970 phospholipase A1 activity 2/430 22/18639 0.0909090909090909 3.94059196617336 0.0906139247174921 0.42485450930417 GO:0034062 5'-3' RNA polymerase activity 2/430 22/18639 0.0909090909090909 3.94059196617336 0.0906139247174921 0.42485450930417 GO:0097747 RNA polymerase activity 2/430 22/18639 0.0909090909090909 3.94059196617336 0.0906139247174921 0.42485450930417 GO:0005504 fatty acid binding 3/430 47/18639 0.0638297872340425 2.76679861454725 0.0940583864074303 0.435785305071112 GO:0140359 ABC-type transporter activity 3/430 47/18639 0.0638297872340425 2.76679861454725 0.0940583864074303 0.435785305071112 GO:0003725 double-stranded RNA binding 4/430 75/18639 0.0533333333333333 2.31181395348837 0.0950859212580441 0.43795456673558 GO:0005212 structural constituent of eye lens 2/430 23/18639 0.0869565217391304 3.76926188068756 0.0977839932865179 0.447747758733003 GO:0030295 protein kinase activator activity 6/430 139/18639 0.0431654676258993 1.87107244437009 0.102996915198293 0.468114644058014 GO:0035254 glutamate receptor binding 3/430 49/18639 0.0612244897959184 2.65386805885145 0.10342762889149 0.468114644058014 GO:0019957 C-C chemokine binding 2/430 24/18639 0.0833333333333333 3.61220930232558 0.105107634152804 0.470281585952259 GO:0030552 cAMP binding 2/430 24/18639 0.0833333333333333 3.61220930232558 0.105107634152804 0.470281585952259 GO:0032813 tumor necrosis factor receptor superfamily binding 3/430 50/18639 0.06 2.60079069767442 0.10824551691629 0.481003409262628 GO:0033293 monocarboxylic acid binding 4/430 79/18639 0.0506329113924051 2.19476008242567 0.109681181847186 0.481003409262628 GO:0001848 complement binding 2/430 25/18639 0.08 3.46772093023256 0.112573986333592 0.481003409262628 GO:0004709 MAP kinase kinase kinase activity 2/430 25/18639 0.08 3.46772093023256 0.112573986333592 0.481003409262628 GO:0003743 translation initiation factor activity 3/430 51/18639 0.0588235294117647 2.54979480164159 0.113148869386525 0.481003409262628 GO:1902936 phosphatidylinositol bisphosphate binding 5/430 111/18639 0.045045045045045 1.95254556882464 0.11414413759084 0.481003409262628 GO:0043021 ribonucleoprotein complex binding 7/430 177/18639 0.0395480225988701 1.71426882144265 0.116102493060027 0.481003409262628 GO:0019955 cytokine binding 6/430 144/18639 0.0416666666666667 1.80610465116279 0.116597632886178 0.481003409262628 GO:0033192 calmodulin-dependent protein phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0140791 histone H2AXS140 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:1990439 MAP kinase serine/threonine phosphatase activity 4/430 81/18639 0.0493827160493827 2.1405684754522 0.117332887827793 0.481003409262628 GO:0005112 Notch binding 2/430 26/18639 0.0769230769230769 3.33434704830054 0.120172606142596 0.484356613963164 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/430 26/18639 0.0769230769230769 3.33434704830054 0.120172606142596 0.484356613963164 GO:0070006 metalloaminopeptidase activity 2/430 26/18639 0.0769230769230769 3.33434704830054 0.120172606142596 0.484356613963164 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4/430 82/18639 0.0487804878048781 2.11446398184912 0.121243801196399 0.484356613963164 GO:0033549 MAP kinase phosphatase activity 4/430 82/18639 0.0487804878048781 2.11446398184912 0.121243801196399 0.484356613963164 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/430 53/18639 0.0566037735849057 2.45357612988153 0.123201693951119 0.486478444903727 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/430 83/18639 0.0481927710843374 2.08898851218829 0.125210040804004 0.486478444903727 GO:0030165 PDZ domain binding 4/430 83/18639 0.0481927710843374 2.08898851218829 0.125210040804004 0.486478444903727 GO:0017124 SH3 domain binding 5/430 115/18639 0.0434782608695652 1.88463094034378 0.127265573541248 0.486478444903727 GO:0001671 ATPase activator activity 2/430 27/18639 0.0740740740740741 3.21085271317829 0.127893453790788 0.486478444903727 GO:0004364 glutathione transferase activity 2/430 27/18639 0.0740740740740741 3.21085271317829 0.127893453790788 0.486478444903727 GO:0008266 poly(U) RNA binding 2/430 27/18639 0.0740740740740741 3.21085271317829 0.127893453790788 0.486478444903727 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/430 27/18639 0.0740740740740741 3.21085271317829 0.127893453790788 0.486478444903727 GO:0015485 cholesterol binding 3/430 54/18639 0.0555555555555556 2.40813953488372 0.128345989096254 0.486478444903727 GO:0019207 kinase regulator activity 10/430 287/18639 0.0348432055749129 1.51033141560651 0.129071281737353 0.486478444903727 GO:0017018 myosin phosphatase activity 4/430 84/18639 0.0476190476190476 2.0641196013289 0.129230544750926 0.486478444903727 GO:0051117 ATPase binding 4/430 84/18639 0.0476190476190476 2.0641196013289 0.129230544750926 0.486478444903727 GO:0098632 cell-cell adhesion mediator activity 3/430 55/18639 0.0545454545454545 2.36435517970402 0.133565403023168 0.49588798015805 GO:0019789 SUMO transferase activity 2/430 28/18639 0.0714285714285714 3.09617940199336 0.135726880381031 0.49588798015805 GO:0051019 mitogen-activated protein kinase binding 2/430 28/18639 0.0714285714285714 3.09617940199336 0.135726880381031 0.49588798015805 GO:0051959 dynein light intermediate chain binding 2/430 28/18639 0.0714285714285714 3.09617940199336 0.135726880381031 0.49588798015805 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/430 28/18639 0.0714285714285714 3.09617940199336 0.135726880381031 0.49588798015805 GO:0019887 protein kinase regulator activity 9/430 255/18639 0.0352941176470588 1.52987688098495 0.136978998045277 0.49588798015805 GO:0015078 proton transmembrane transporter activity 7/430 185/18639 0.0378378378378378 1.6401382778127 0.136993332590075 0.49588798015805 GO:1901981 phosphatidylinositol phosphate binding 7/430 185/18639 0.0378378378378378 1.6401382778127 0.136993332590075 0.49588798015805 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 4/430 86/18639 0.0465116279069767 2.01611681990265 0.137430002163853 0.49588798015805 GO:0008081 phosphoric diester hydrolase activity 4/430 87/18639 0.0459770114942529 1.99294306335204 0.141606739965375 0.508615033912332 GO:0003785 actin monomer binding 2/430 29/18639 0.0689655172413793 2.98941459502807 0.14366361528558 0.513289041944402 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/430 57/18639 0.0526315789473684 2.28139534883721 0.144219143330483 0.513289041944402 GO:0046982 protein heterodimerization activity 12/430 369/18639 0.032520325203252 1.40964265456608 0.147780919937908 0.522585108765284 GO:0051082 unfolded protein binding 5/430 121/18639 0.0413223140495868 1.79117816644244 0.148165892906632 0.522585108765284 GO:0008187 poly-pyrimidine tract binding 2/430 30/18639 0.0666666666666667 2.88976744186047 0.151694753895775 0.523246662116263 GO:0016769 transferase activity, transferring nitrogenous groups 2/430 30/18639 0.0666666666666667 2.88976744186047 0.151694753895775 0.523246662116263 GO:0031210 phosphatidylcholine binding 2/430 30/18639 0.0666666666666667 2.88976744186047 0.151694753895775 0.523246662116263 GO:0031624 ubiquitin conjugating enzyme binding 2/430 30/18639 0.0666666666666667 2.88976744186047 0.151694753895775 0.523246662116263 GO:0048019 receptor antagonist activity 2/430 30/18639 0.0666666666666667 2.88976744186047 0.151694753895775 0.523246662116263 GO:0004879 nuclear receptor activity 3/430 59/18639 0.0508474576271186 2.20405991328341 0.155142025563324 0.530463781729617 GO:0070888 E-box binding 3/430 59/18639 0.0508474576271186 2.20405991328341 0.155142025563324 0.530463781729617 GO:0005164 tumor necrosis factor receptor binding 2/430 31/18639 0.0645161290322581 2.79654913728432 0.159811745733538 0.541699553720173 GO:0047499 calcium-independent phospholipase A2 activity 2/430 31/18639 0.0645161290322581 2.79654913728432 0.159811745733538 0.541699553720173 GO:0098531 ligand-modulated transcription factor activity 3/430 60/18639 0.05 2.16732558139535 0.160697883126223 0.542355355551002 GO:0030515 snoRNA binding 2/430 32/18639 0.0625 2.70915697674419 0.168006382914546 0.559782969455701 GO:0031369 translation initiation factor binding 2/430 32/18639 0.0625 2.70915697674419 0.168006382914546 0.559782969455701 GO:0047498 calcium-dependent phospholipase A2 activity 2/430 32/18639 0.0625 2.70915697674419 0.168006382914546 0.559782969455701 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/430 33/18639 0.0606060606060606 2.62706131078224 0.176270788953262 0.577489655859431 GO:0019956 chemokine binding 2/430 33/18639 0.0606060606060606 2.62706131078224 0.176270788953262 0.577489655859431 GO:0071889 14-3-3 protein binding 2/430 33/18639 0.0606060606060606 2.62706131078224 0.176270788953262 0.577489655859431 GO:0140416 transcription regulator inhibitor activity 2/430 33/18639 0.0606060606060606 2.62706131078224 0.176270788953262 0.577489655859431 GO:0031072 heat shock protein binding 5/430 131/18639 0.0381679389312977 1.65444700869874 0.185921443483048 0.598143801905887 GO:0008235 metalloexopeptidase activity 3/430 66/18639 0.0454545454545455 1.97029598308668 0.195192678261726 0.598143801905887 GO:0043130 ubiquitin binding 4/430 100/18639 0.04 1.73386046511628 0.20001165125714 0.598143801905887 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/430 36/18639 0.0555555555555556 2.40813953488372 0.201408600476784 0.598143801905887 GO:0005484 SNAP receptor activity 2/430 36/18639 0.0555555555555556 2.40813953488372 0.201408600476784 0.598143801905887 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/430 36/18639 0.0555555555555556 2.40813953488372 0.201408600476784 0.598143801905887 GO:0140789 histone phosphatase activity 5/430 136/18639 0.0367647058823529 1.59362175102599 0.205991837247329 0.598143801905887 GO:0005548 phospholipid transporter activity 3/430 68/18639 0.0441176470588235 1.91234610123119 0.207072076428881 0.598143801905887 GO:0030145 manganese ion binding 3/430 68/18639 0.0441176470588235 1.91234610123119 0.207072076428881 0.598143801905887 GO:0032934 sterol binding 3/430 68/18639 0.0441176470588235 1.91234610123119 0.207072076428881 0.598143801905887 GO:0003796 lysozyme activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0004090 carbonyl reductase (NADPH) activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0004382 GDP phosphatase activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0004955 prostaglandin receptor activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0005337 nucleoside transmembrane transporter activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0005345 purine nucleobase transmembrane transporter activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0005522 profilin binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0008190 eukaryotic initiation factor 4E binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0008239 dipeptidyl-peptidase activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0031419 cobalamin binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0032395 MHC class II receptor activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0042975 peroxisome proliferator activated receptor binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0043208 glycosphingolipid binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0051880 G-quadruplex DNA binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0070513 death domain binding 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0141109 transporter activator activity 1/430 10/18639 0.1 4.3346511627907 0.208209827827354 0.598143801905887 GO:0019213 deacetylase activity 2/430 37/18639 0.0540540540540541 2.34305468258957 0.209879571590694 0.598143801905887 GO:0030551 cyclic nucleotide binding 2/430 37/18639 0.0540540540540541 2.34305468258957 0.209879571590694 0.598143801905887 GO:0016922 nuclear receptor binding 5/430 137/18639 0.0364963503649635 1.58198947547106 0.21008991068651 0.598143801905887 GO:0002039 p53 binding 3/430 69/18639 0.0434782608695652 1.88463094034378 0.21307211918182 0.598143801905887 GO:0004722 protein serine/threonine phosphatase activity 4/430 103/18639 0.0388349514563107 1.68335967487017 0.214409319284955 0.598143801905887 GO:0004721 phosphoprotein phosphatase activity 6/430 175/18639 0.0342857142857143 1.48616611295681 0.21818528700369 0.598143801905887 GO:0042578 phosphoric ester hydrolase activity 11/430 363/18639 0.0303030303030303 1.31353065539112 0.219098724174046 0.598143801905887 GO:0003953 NAD+ nucleosidase activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0004954 prostanoid receptor activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0008503 benzodiazepine receptor activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0008526 phosphatidylinositol transfer activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0010854 adenylate cyclase regulator activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0015173 aromatic amino acid transmembrane transporter activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0015205 nucleobase transmembrane transporter activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0019215 intermediate filament binding 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0034056 estrogen response element binding 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0034511 U3 snoRNA binding 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0070990 snRNP binding 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0097493 structural molecule activity conferring elasticity 1/430 11/18639 0.0909090909090909 3.94059196617336 0.226486159033228 0.598143801905887 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/430 39/18639 0.0512820512820513 2.22289803220036 0.226920373595284 0.598143801905887 GO:0000149 SNARE binding 4/430 106/18639 0.0377358490566038 1.63571741992102 0.22908217005526 0.598143801905887 GO:0019888 protein phosphatase regulator activity 4/430 107/18639 0.0373831775700935 1.62043034123017 0.234028570203926 0.598143801905887 GO:0004532 RNA exonuclease activity 2/430 40/18639 0.05 2.16732558139535 0.235478255882003 0.598143801905887 GO:0015036 disulfide oxidoreductase activity 2/430 40/18639 0.05 2.16732558139535 0.235478255882003 0.598143801905887 GO:0030331 nuclear estrogen receptor binding 2/430 40/18639 0.05 2.16732558139535 0.235478255882003 0.598143801905887 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/430 40/18639 0.05 2.16732558139535 0.235478255882003 0.598143801905887 GO:0043539 protein serine/threonine kinase activator activity 3/430 73/18639 0.0410958904109589 1.78136349155782 0.237418981234516 0.598143801905887 GO:0004843 cysteine-type deubiquitinase activity 4/430 108/18639 0.037037037037037 1.60542635658915 0.239000670830709 0.598143801905887 GO:0005496 steroid binding 4/430 108/18639 0.037037037037037 1.60542635658915 0.239000670830709 0.598143801905887 GO:0019903 protein phosphatase binding 5/430 144/18639 0.0347222222222222 1.50508720930233 0.239470733252899 0.598143801905887 GO:0004000 adenosine deaminase activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0004875 complement receptor activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0005095 GTPase inhibitor activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0008603 cAMP-dependent protein kinase regulator activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0010853 cyclase activator activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0015269 calcium-activated potassium channel activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0016801 hydrolase activity, acting on ether bonds 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0016803 ether hydrolase activity 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0017166 vinculin binding 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0035259 nuclear glucocorticoid receptor binding 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0035497 cAMP response element binding 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0070410 co-SMAD binding 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0097677 STAT family protein binding 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/430 12/18639 0.0833333333333333 3.61220930232558 0.244341589117817 0.598143801905887 GO:0008237 metallopeptidase activity 6/430 184/18639 0.0326086956521739 1.41347320525784 0.252103082714108 0.598143801905887 GO:0035198 miRNA binding 2/430 42/18639 0.0476190476190476 2.0641196013289 0.252641022822053 0.598143801905887 GO:0003712 transcription coregulator activity 14/430 495/18639 0.0282828282828283 1.22596194503171 0.254944221508756 0.598143801905887 GO:0017022 myosin binding 3/430 76/18639 0.0394736842105263 1.71104651162791 0.255978634167403 0.598143801905887 GO:0098631 cell adhesion mediator activity 3/430 76/18639 0.0394736842105263 1.71104651162791 0.255978634167403 0.598143801905887 GO:0022804 active transmembrane transporter activity 13/430 457/18639 0.0284463894967177 1.23305175309145 0.258764708388328 0.598143801905887 GO:0043022 ribosome binding 4/430 112/18639 0.0357142857142857 1.54808970099668 0.259122021866259 0.598143801905887 GO:0008200 ion channel inhibitor activity 2/430 43/18639 0.0465116279069767 2.01611681990265 0.261235452127603 0.598143801905887 GO:0008375 acetylglucosaminyltransferase activity 2/430 43/18639 0.0465116279069767 2.01611681990265 0.261235452127603 0.598143801905887 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0005542 folic acid binding 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0008035 high-density lipoprotein particle binding 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0032396 inhibitory MHC class I receptor activity 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0035325 Toll-like receptor binding 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0046974 histone H3K9 methyltransferase activity 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0046975 histone H3K36 methyltransferase activity 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0071837 HMG box domain binding 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0089720 caspase binding 1/430 13/18639 0.0769230769230769 3.33434704830054 0.26178578929387 0.598143801905887 GO:0031406 carboxylic acid binding 6/430 187/18639 0.0320855614973262 1.39079716453177 0.263726039579455 0.598143801905887 GO:0019842 vitamin binding 5/430 150/18639 0.0333333333333333 1.44488372093023 0.265485261564813 0.598143801905887 GO:0016248 channel inhibitor activity 2/430 44/18639 0.0454545454545455 1.97029598308668 0.269831994189643 0.598143801905887 GO:0019205 nucleobase-containing compound kinase activity 2/430 44/18639 0.0454545454545455 1.97029598308668 0.269831994189643 0.598143801905887 GO:0043014 alpha-tubulin binding 2/430 44/18639 0.0454545454545455 1.97029598308668 0.269831994189643 0.598143801905887 GO:0043177 organic acid binding 6/430 189/18639 0.0317460317460317 1.37607973421927 0.271550673164593 0.598143801905887 GO:0035401 histone H3Y41 kinase activity 4/430 115/18639 0.0347826086956522 1.50770475227503 0.274424381987562 0.598143801905887 GO:0101005 deubiquitinase activity 4/430 115/18639 0.0347826086956522 1.50770475227503 0.274424381987562 0.598143801905887 GO:0140801 histone H2AXY142 kinase activity 4/430 115/18639 0.0347826086956522 1.50770475227503 0.274424381987562 0.598143801905887 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/430 45/18639 0.0444444444444444 1.92651162790698 0.278425988204298 0.598143801905887 GO:0140303 intramembrane lipid transporter activity 2/430 45/18639 0.0444444444444444 1.92651162790698 0.278425988204298 0.598143801905887 GO:0141110 transporter inhibitor activity 2/430 45/18639 0.0444444444444444 1.92651162790698 0.278425988204298 0.598143801905887 GO:0003774 cytoskeletal motor activity 5/430 153/18639 0.0326797385620915 1.41655266757866 0.278726267729569 0.598143801905887 GO:0004065 arylsulfatase activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0005347 ATP transmembrane transporter activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0008191 metalloendopeptidase inhibitor activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0008494 translation activator activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0015926 glucosidase activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0016530 metallochaperone activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0042043 neurexin family protein binding 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0043176 amine binding 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0061665 SUMO ligase activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0061783 peptidoglycan muralytic activity 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0071933 Arp2/3 complex binding 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/430 14/18639 0.0714285714285714 3.09617940199336 0.278828209062131 0.598143801905887 GO:0000287 magnesium ion binding 7/430 230/18639 0.0304347826086957 1.31924165824065 0.281845513253449 0.601321626369076 GO:0005085 guanyl-nucleotide exchange factor activity 7/430 230/18639 0.0304347826086957 1.31924165824065 0.281845513253449 0.601321626369076 GO:0005506 iron ion binding 5/430 154/18639 0.0324675324675325 1.40735427363334 0.28316960553311 0.602504894381591 GO:0019208 phosphatase regulator activity 4/430 117/18639 0.0341880341880342 1.48193202146691 0.284709088640904 0.604138797847771 GO:0004180 carboxypeptidase activity 2/430 46/18639 0.0434782608695652 1.88463094034378 0.287012986316053 0.607381535906675 GO:0005096 GTPase activator activity 8/430 271/18639 0.029520295202952 1.27960181927401 0.289294744549533 0.610560067337693 GO:0004953 icosanoid receptor activity 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0005041 low-density lipoprotein particle receptor activity 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0005523 tropomyosin binding 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0030553 cGMP binding 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0050700 CARD domain binding 1/430 15/18639 0.0666666666666667 2.88976744186047 0.295478081282442 0.612290974503413 GO:0001784 phosphotyrosine residue binding 2/430 47/18639 0.0425531914893617 1.84453240969817 0.295588746311993 0.612290974503413 GO:0032182 ubiquitin-like protein binding 4/430 120/18639 0.0333333333333333 1.44488372093023 0.300238072684535 0.617964269473675 GO:0032266 phosphatidylinositol-3-phosphate binding 2/430 48/18639 0.0416666666666667 1.80610465116279 0.3041492245385 0.617964269473675 GO:0140693 molecular condensate scaffold activity 2/430 48/18639 0.0416666666666667 1.80610465116279 0.3041492245385 0.617964269473675 GO:0051020 GTPase binding 9/430 315/18639 0.0285714285714286 1.23847176079734 0.304278238347438 0.617964269473675 GO:0004860 protein kinase inhibitor activity 3/430 84/18639 0.0357142857142857 1.54808970099668 0.306249891572446 0.617964269473675 GO:0004708 MAP kinase kinase activity 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0005159 insulin-like growth factor receptor binding 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0005521 lamin binding 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0008296 3'-5'-DNA exonuclease activity 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0016722 oxidoreductase activity, acting on metal ions 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0022858 alanine transmembrane transporter activity 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0030275 LRR domain binding 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0140328 floppase activity 1/430 16/18639 0.0625 2.70915697674419 0.311744427129121 0.617964269473675 GO:0060590 ATPase regulator activity 2/430 49/18639 0.0408163265306122 1.76924537256763 0.312690569034118 0.618274534226551 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0016805 dipeptidase activity 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0017110 nucleoside diphosphate phosphatase activity 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0019198 transmembrane receptor protein phosphatase activity 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0031489 myosin V binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0036041 long-chain fatty acid binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0038191 neuropilin binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0046965 nuclear retinoid X receptor binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0048038 quinone binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0070492 oligosaccharide binding 1/430 17/18639 0.0588235294117647 2.54979480164159 0.327636060933259 0.621013806727032 GO:0005048 signal sequence binding 2/430 51/18639 0.0392156862745098 1.69986320109439 0.329701367708517 0.621013806727032 GO:0030544 Hsp70 protein binding 2/430 51/18639 0.0392156862745098 1.69986320109439 0.329701367708517 0.621013806727032 GO:0003714 transcription corepressor activity 6/430 204/18639 0.0294117647058824 1.27489740082079 0.3317330308168 0.621013806727032 GO:0019783 ubiquitin-like protein peptidase activity 4/430 127/18639 0.031496062992126 1.36524446072148 0.336794451987182 0.621013806727032 GO:0003727 single-stranded RNA binding 3/430 89/18639 0.0337078651685393 1.46111836948001 0.337902091055963 0.621013806727032 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/430 89/18639 0.0337078651685393 1.46111836948001 0.337902091055963 0.621013806727032 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/430 89/18639 0.0337078651685393 1.46111836948001 0.337902091055963 0.621013806727032 GO:0005080 protein kinase C binding 2/430 52/18639 0.0384615384615385 1.66717352415027 0.338164017524586 0.621013806727032 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/430 52/18639 0.0384615384615385 1.66717352415027 0.338164017524586 0.621013806727032 GO:0030695 GTPase regulator activity 13/430 489/18639 0.0265848670756646 1.15236124982166 0.340352393442098 0.621013806727032 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/430 128/18639 0.03125 1.35457848837209 0.342038103977511 0.621013806727032 GO:0060589 nucleoside-triphosphatase regulator activity 13/430 490/18639 0.026530612244898 1.15000949216896 0.342994082892346 0.621013806727032 GO:0000400 four-way junction DNA binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0000900 mRNA regulatory element binding translation repressor activity 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0016854 racemase and epimerase activity 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0017075 syntaxin-1 binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0017128 phospholipid scramblase activity 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0030228 lipoprotein particle receptor activity 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0034185 apolipoprotein binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0035615 clathrin adaptor activity 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0050811 GABA receptor binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0098641 cadherin binding involved in cell-cell adhesion 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:1901611 phosphatidylglycerol binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:1990381 ubiquitin-specific protease binding 1/430 18/18639 0.0555555555555556 2.40813953488372 0.343161594914502 0.621013806727032 GO:0005516 calmodulin binding 6/430 207/18639 0.0289855072463768 1.25642062689585 0.343994523002127 0.621013806727032 GO:0019210 kinase inhibitor activity 3/430 90/18639 0.0333333333333333 1.44488372093023 0.34422866761987 0.621013806727032 GO:0140793 histone H2AXY142 phosphatase activity 3/430 90/18639 0.0333333333333333 1.44488372093023 0.34422866761987 0.621013806727032 GO:0004864 protein phosphatase inhibitor activity 2/430 53/18639 0.0377358490566038 1.63571741992102 0.346593912566683 0.621013806727032 GO:0005544 calcium-dependent phospholipid binding 2/430 53/18639 0.0377358490566038 1.63571741992102 0.346593912566683 0.621013806727032 GO:0140296 general transcription initiation factor binding 2/430 53/18639 0.0377358490566038 1.63571741992102 0.346593912566683 0.621013806727032 GO:0051287 NAD binding 2/430 54/18639 0.037037037037037 1.60542635658915 0.354988063469392 0.627677750557451 GO:0141108 transporter regulator activity 5/430 170/18639 0.0294117647058824 1.27489740082079 0.355624615715444 0.627677750557451 GO:0043178 alcohol binding 3/430 92/18639 0.0326086956521739 1.41347320525784 0.356864751998206 0.627677750557451 GO:0005262 calcium channel activity 4/430 131/18639 0.0305343511450382 1.32355760695899 0.357778811797519 0.627677750557451 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:0008301 DNA binding, bending 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:0015245 fatty acid transmembrane transporter activity 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:0034987 immunoglobulin receptor binding 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:0046624 sphingolipid transporter activity 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:1990380 K48-linked deubiquitinase activity 1/430 19/18639 0.0526315789473684 2.28139534883721 0.358329443804829 0.627677750557451 GO:0019212 phosphatase inhibitor activity 2/430 56/18639 0.0357142857142857 1.54808970099668 0.371657943349304 0.637936136231888 GO:0030170 pyridoxal phosphate binding 2/430 56/18639 0.0357142857142857 1.54808970099668 0.371657943349304 0.637936136231888 GO:0170055 lipid transmembrane transporter activity 2/430 56/18639 0.0357142857142857 1.54808970099668 0.371657943349304 0.637936136231888 GO:0001614 purinergic nucleotide receptor activity 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0001972 retinoic acid binding 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0005326 neurotransmitter transmembrane transporter activity 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0010851 cyclase regulator activity 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0016502 nucleotide receptor activity 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0030742 GTP-dependent protein binding 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0043024 ribosomal small subunit binding 1/430 20/18639 0.05 2.16732558139535 0.373147829366801 0.637936136231888 GO:0004601 peroxidase activity 2/430 57/18639 0.0350877192982456 1.52093023255814 0.379928445168171 0.64670428818843 GO:0070279 vitamin B6 binding 2/430 57/18639 0.0350877192982456 1.52093023255814 0.379928445168171 0.64670428818843 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0005123 death receptor binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0008373 sialyltransferase activity 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0010314 phosphatidylinositol-5-phosphate binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0035613 RNA stem-loop binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0051428 peptide hormone receptor binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0070182 DNA polymerase binding 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0140312 cargo adaptor activity 1/430 21/18639 0.0476190476190476 2.0641196013289 0.387624784808676 0.647123461867463 GO:0061980 regulatory RNA binding 2/430 58/18639 0.0344827586206897 1.49470729751403 0.388152738004482 0.647123461867463 GO:0005261 monoatomic cation channel activity 9/430 341/18639 0.0263929618768328 1.14404282888904 0.388439370469614 0.647123461867463 GO:0004725 protein tyrosine phosphatase activity 3/430 98/18639 0.0306122448979592 1.32693402942572 0.394527607175446 0.649967910277494 GO:0015459 potassium channel regulator activity 2/430 59/18639 0.0338983050847458 1.46937327552227 0.396328552476102 0.649967910277494 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/430 59/18639 0.0338983050847458 1.46937327552227 0.396328552476102 0.649967910277494 GO:0031593 polyubiquitin modification-dependent protein binding 2/430 59/18639 0.0338983050847458 1.46937327552227 0.396328552476102 0.649967910277494 GO:0045309 protein phosphorylated amino acid binding 2/430 59/18639 0.0338983050847458 1.46937327552227 0.396328552476102 0.649967910277494 GO:0070063 RNA polymerase binding 2/430 59/18639 0.0338983050847458 1.46937327552227 0.396328552476102 0.649967910277494 GO:0008093 cytoskeletal anchor activity 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0031683 G-protein beta/gamma-subunit complex binding 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0033691 sialic acid binding 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0050321 tau-protein kinase activity 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0061133 endopeptidase activator activity 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0070034 telomerase RNA binding 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0140517 protein-RNA adaptor activity 1/430 22/18639 0.0454545454545455 1.97029598308668 0.401768159098732 0.649967910277494 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/430 60/18639 0.0333333333333333 1.44488372093023 0.404453747970925 0.652289443440491 GO:0004713 protein tyrosine kinase activity 4/430 140/18639 0.0285714285714286 1.23847176079734 0.404869309721684 0.652289443440491 GO:0015026 coreceptor activity 2/430 61/18639 0.0327868852459016 1.42119710255433 0.412526307937565 0.653420765832943 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/430 61/18639 0.0327868852459016 1.42119710255433 0.412526307937565 0.653420765832943 GO:0019905 syntaxin binding 2/430 61/18639 0.0327868852459016 1.42119710255433 0.412526307937565 0.653420765832943 GO:0000295 adenine nucleotide transmembrane transporter activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0003887 DNA-directed DNA polymerase activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0004602 glutathione peroxidase activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0016493 C-C chemokine receptor activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0016849 phosphorus-oxygen lyase activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0043274 phospholipase binding 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0070577 lysine-acetylated histone binding 1/430 23/18639 0.0434782608695652 1.88463094034378 0.415585621181106 0.653420765832943 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0005315 phosphate transmembrane transporter activity 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0005540 hyaluronic acid binding 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0015295 solute:proton symporter activity 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0030215 semaphorin receptor binding 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0035035 histone acetyltransferase binding 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0140033 acetylation-dependent protein binding 1/430 24/18639 0.0416666666666667 1.80610465116279 0.429084664095379 0.659977083218927 GO:0015085 calcium ion transmembrane transporter activity 4/430 147/18639 0.0272108843537415 1.17949691504509 0.441053313389195 0.659977083218927 GO:0003707 nuclear steroid receptor activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0005251 delayed rectifier potassium channel activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0005537 D-mannose binding 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0008139 nuclear localization sequence binding 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0008483 transaminase activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0015662 P-type ion transporter activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0017025 TBP-class protein binding 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0019707 protein-cysteine S-acyltransferase activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0042974 nuclear retinoic acid receptor binding 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0140358 P-type transmembrane transporter activity 1/430 25/18639 0.04 1.73386046511628 0.442272609002121 0.659977083218927 GO:0016791 phosphatase activity 7/430 273/18639 0.0256410256410256 1.11144901610018 0.442338460669583 0.659977083218927 GO:0019843 rRNA binding 2/430 65/18639 0.0307692307692308 1.33373881932021 0.444253952169905 0.659977083218927 GO:0160215 deacylase activity 2/430 65/18639 0.0307692307692308 1.33373881932021 0.444253952169905 0.659977083218927 GO:0003779 actin binding 11/430 443/18639 0.0248306997742664 1.0763242164943 0.44507053750326 0.659977083218927 GO:0019902 phosphatase binding 5/430 190/18639 0.0263157894736842 1.1406976744186 0.446822199042551 0.659977083218927 GO:0001637 G protein-coupled chemoattractant receptor activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0004435 phosphatidylinositol phospholipase C activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0004529 DNA exonuclease activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0004950 chemokine receptor activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0005160 transforming growth factor beta receptor binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0005227 calcium-activated cation channel activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0008143 poly(A) binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0008157 protein phosphatase 1 binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0015216 purine nucleotide transmembrane transporter activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0030507 spectrin binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0050681 nuclear androgen receptor binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0050750 low-density lipoprotein particle receptor binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0097602 cullin family protein binding 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0120014 phospholipid transfer activity 1/430 26/18639 0.0384615384615385 1.66717352415027 0.455156609116502 0.659977083218927 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/430 67/18639 0.0298507462686567 1.29392572023603 0.459757906613014 0.664241687763952 GO:0005216 monoatomic ion channel activity 11/430 448/18639 0.0245535714285714 1.06431166943522 0.459794373905571 0.664241687763952 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/430 27/18639 0.037037037037037 1.60542635658915 0.467743653552106 0.670775239434614 GO:0008395 steroid hydroxylase activity 1/430 27/18639 0.037037037037037 1.60542635658915 0.467743653552106 0.670775239434614 GO:0015252 proton channel activity 1/430 27/18639 0.037037037037037 1.60542635658915 0.467743653552106 0.670775239434614 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/430 27/18639 0.037037037037037 1.60542635658915 0.467743653552106 0.670775239434614 GO:0031267 small GTPase binding 7/430 283/18639 0.0247349823321555 1.07217519927685 0.479587307701852 0.679695781470633 GO:0005200 structural constituent of cytoskeleton 3/430 112/18639 0.0267857142857143 1.16106727574751 0.479650525541495 0.679695781470633 GO:0045499 chemorepellent activity 1/430 28/18639 0.0357142857142857 1.54808970099668 0.480040571076961 0.679695781470633 GO:0046875 ephrin receptor binding 1/430 28/18639 0.0357142857142857 1.54808970099668 0.480040571076961 0.679695781470633 GO:0051393 alpha-actinin binding 1/430 28/18639 0.0357142857142857 1.54808970099668 0.480040571076961 0.679695781470633 GO:0051537 2 iron, 2 sulfur cluster binding 1/430 28/18639 0.0357142857142857 1.54808970099668 0.480040571076961 0.679695781470633 GO:0097718 disordered domain specific binding 1/430 28/18639 0.0357142857142857 1.54808970099668 0.480040571076961 0.679695781470633 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/430 70/18639 0.0285714285714286 1.23847176079734 0.482533796878715 0.680763897218079 GO:0097110 scaffold protein binding 2/430 70/18639 0.0285714285714286 1.23847176079734 0.482533796878715 0.680763897218079 GO:0004629 phospholipase C activity 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0016417 S-acyltransferase activity 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0035250 UDP-galactosyltransferase activity 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0097472 cyclin-dependent protein kinase activity 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0106222 lncRNA binding 1/430 29/18639 0.0344827586206897 1.49470729751403 0.492054033783796 0.686770603302517 GO:0001221 transcription coregulator binding 3/430 115/18639 0.0260869565217391 1.13077856420627 0.497181166469112 0.692691909867109 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/430 30/18639 0.0333333333333333 1.44488372093023 0.503790560676486 0.695710774267529 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/430 30/18639 0.0333333333333333 1.44488372093023 0.503790560676486 0.695710774267529 GO:0015215 nucleotide transmembrane transporter activity 1/430 30/18639 0.0333333333333333 1.44488372093023 0.503790560676486 0.695710774267529 GO:0022839 monoatomic ion-gated channel activity 1/430 30/18639 0.0333333333333333 1.44488372093023 0.503790560676486 0.695710774267529 GO:0033612 receptor serine/threonine kinase binding 1/430 30/18639 0.0333333333333333 1.44488372093023 0.503790560676486 0.695710774267529 GO:0099106 ion channel regulator activity 4/430 160/18639 0.025 1.08366279069767 0.506301666867445 0.697947544290862 GO:1990782 protein tyrosine kinase binding 3/430 117/18639 0.0256410256410256 1.11144901610018 0.508702153025459 0.700024228152784 GO:0003684 damaged DNA binding 2/430 74/18639 0.027027027027027 1.17152734129478 0.511961487234597 0.702041759202608 GO:0048029 monosaccharide binding 2/430 74/18639 0.027027027027027 1.17152734129478 0.511961487234597 0.702041759202608 GO:0008327 methyl-CpG binding 1/430 31/18639 0.032258064516129 1.39827456864216 0.515256521174585 0.702721713503658 GO:0070273 phosphatidylinositol-4-phosphate binding 1/430 31/18639 0.032258064516129 1.39827456864216 0.515256521174585 0.702721713503658 GO:0070325 lipoprotein particle receptor binding 1/430 31/18639 0.032258064516129 1.39827456864216 0.515256521174585 0.702721713503658 GO:0008083 growth factor activity 4/430 162/18639 0.0246913580246914 1.0702842377261 0.51604723533155 0.702721713503658 GO:0008378 galactosyltransferase activity 1/430 32/18639 0.03125 1.35457848837209 0.526458138537811 0.710718487026045 GO:0022884 macromolecule transmembrane transporter activity 1/430 32/18639 0.03125 1.35457848837209 0.526458138537811 0.710718487026045 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/430 32/18639 0.03125 1.35457848837209 0.526458138537811 0.710718487026045 GO:0043425 bHLH transcription factor binding 1/430 32/18639 0.03125 1.35457848837209 0.526458138537811 0.710718487026045 GO:0070717 poly-purine tract binding 1/430 32/18639 0.03125 1.35457848837209 0.526458138537811 0.710718487026045 GO:0003697 single-stranded DNA binding 3/430 121/18639 0.0247933884297521 1.07470689986546 0.531321380598279 0.716049296055856 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/430 122/18639 0.0245901639344262 1.06589782691575 0.536884632882665 0.720522892440502 GO:0019239 deaminase activity 1/430 33/18639 0.0303030303030303 1.31353065539112 0.537401493212329 0.720522892440502 GO:0030296 protein tyrosine kinase activator activity 1/430 33/18639 0.0303030303030303 1.31353065539112 0.537401493212329 0.720522892440502 GO:0016247 channel regulator activity 4/430 168/18639 0.0238095238095238 1.03205980066445 0.544730372358712 0.727383810062288 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/430 34/18639 0.0294117647058824 1.27489740082079 0.548092526100574 0.727383810062288 GO:0016831 carboxy-lyase activity 1/430 34/18639 0.0294117647058824 1.27489740082079 0.548092526100574 0.727383810062288 GO:0019825 oxygen binding 1/430 34/18639 0.0294117647058824 1.27489740082079 0.548092526100574 0.727383810062288 GO:0030332 cyclin binding 1/430 34/18639 0.0294117647058824 1.27489740082079 0.548092526100574 0.727383810062288 GO:0051427 hormone receptor binding 1/430 34/18639 0.0294117647058824 1.27489740082079 0.548092526100574 0.727383810062288 GO:0019787 ubiquitin-like protein transferase activity 11/430 479/18639 0.022964509394572 0.995431373500995 0.549194238050445 0.727612670716579 GO:0000175 3'-5'-RNA exonuclease activity 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0016229 steroid dehydrogenase activity 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0034061 DNA polymerase activity 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0043015 gamma-tubulin binding 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0061631 ubiquitin conjugating enzyme activity 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0140566 histone reader activity 1/430 35/18639 0.0285714285714286 1.23847176079734 0.558537041756406 0.732553607529759 GO:0030971 receptor tyrosine kinase binding 2/430 81/18639 0.0246913580246914 1.0702842377261 0.560741205207586 0.734214654979163 GO:0003730 mRNA 3'-UTR binding 6/430 262/18639 0.0229007633587786 0.992668205219244 0.564524310398903 0.73578213443124 GO:0140030 modification-dependent protein binding 4/430 173/18639 0.023121387283237 1.00223148272617 0.567949357486236 0.73578213443124 GO:0004033 aldo-keto reductase (NADPH) activity 1/430 36/18639 0.0277777777777778 1.20406976744186 0.568740711507253 0.73578213443124 GO:0004190 aspartic-type endopeptidase activity 1/430 36/18639 0.0277777777777778 1.20406976744186 0.568740711507253 0.73578213443124 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/430 36/18639 0.0277777777777778 1.20406976744186 0.568740711507253 0.73578213443124 GO:0016409 palmitoyltransferase activity 1/430 36/18639 0.0277777777777778 1.20406976744186 0.568740711507253 0.73578213443124 GO:0045505 dynein intermediate chain binding 1/430 36/18639 0.0277777777777778 1.20406976744186 0.568740711507253 0.73578213443124 GO:0031490 chromatin DNA binding 3/430 128/18639 0.0234375 1.01593386627907 0.569455904808852 0.73578213443124 GO:0042805 actinin binding 1/430 37/18639 0.027027027027027 1.17152734129478 0.578709076504935 0.745204500150765 GO:0070001 aspartic-type peptidase activity 1/430 37/18639 0.027027027027027 1.17152734129478 0.578709076504935 0.745204500150765 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3/430 130/18639 0.0230769230769231 1.00030411449016 0.579994871569209 0.745204500150765 GO:0004527 exonuclease activity 2/430 84/18639 0.0238095238095238 1.03205980066445 0.580555230002512 0.745204500150765 GO:0005109 frizzled binding 1/430 38/18639 0.0263157894736842 1.1406976744186 0.588447550706788 0.750414384696116 GO:0005501 retinoid binding 1/430 38/18639 0.0263157894736842 1.1406976744186 0.588447550706788 0.750414384696116 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/430 38/18639 0.0263157894736842 1.1406976744186 0.588447550706788 0.750414384696116 GO:0019840 isoprenoid binding 1/430 38/18639 0.0263157894736842 1.1406976744186 0.588447550706788 0.750414384696116 GO:0004842 ubiquitin-protein transferase activity 10/430 449/18639 0.022271714922049 0.965401149842026 0.589918772737824 0.7504215752265 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3/430 132/18639 0.0227272727272727 0.98514799154334 0.590369974890835 0.7504215752265 GO:0106310 protein serine kinase activity 8/430 361/18639 0.0221606648199446 0.960587515299878 0.595634434327565 0.754999195337203 GO:0016755 aminoacyltransferase activity 11/430 496/18639 0.0221774193548387 0.961313765941485 0.595899748043923 0.754999195337203 GO:0000217 DNA secondary structure binding 1/430 39/18639 0.0256410256410256 1.11144901610018 0.59796142378867 0.75516741101053 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/430 39/18639 0.0256410256410256 1.11144901610018 0.59796142378867 0.75516741101053 GO:0051087 protein-folding chaperone binding 3/430 134/18639 0.0223880597014925 0.970444290177022 0.600578875684619 0.757251625863216 GO:0015144 carbohydrate transmembrane transporter activity 1/430 40/18639 0.025 1.08366279069767 0.607255863991405 0.761989329335369 GO:0071855 neuropeptide receptor binding 1/430 40/18639 0.025 1.08366279069767 0.607255863991405 0.761989329335369 GO:0071949 FAD binding 1/430 40/18639 0.025 1.08366279069767 0.607255863991405 0.761989329335369 GO:0016779 nucleotidyltransferase activity 3/430 136/18639 0.0220588235294118 0.956173050615595 0.610619573079991 0.763762181663951 GO:0099094 ligand-gated monoatomic cation channel activity 3/430 136/18639 0.0220588235294118 0.956173050615595 0.610619573079991 0.763762181663951 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 1/430 41/18639 0.024390243902439 1.05723199092456 0.61633592090219 0.766017501692722 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/430 41/18639 0.024390243902439 1.05723199092456 0.61633592090219 0.766017501692722 GO:0042169 SH2 domain binding 1/430 41/18639 0.024390243902439 1.05723199092456 0.61633592090219 0.766017501692722 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/430 41/18639 0.024390243902439 1.05723199092456 0.61633592090219 0.766017501692722 GO:0019894 kinesin binding 1/430 42/18639 0.0238095238095238 1.03205980066445 0.625206528172437 0.773551614247825 GO:0051879 Hsp90 protein binding 1/430 42/18639 0.0238095238095238 1.03205980066445 0.625206528172437 0.773551614247825 GO:0070851 growth factor receptor binding 3/430 139/18639 0.0215827338129496 0.935536222185043 0.625361649832533 0.773551614247825 GO:0061659 ubiquitin-like protein ligase activity 8/430 372/18639 0.021505376344086 0.93218304576144 0.629324857795248 0.777015138858153 GO:0052689 carboxylic ester hydrolase activity 2/430 92/18639 0.0217391304347826 0.942315470171891 0.630146376979473 0.777015138858153 GO:0046943 carboxylic acid transmembrane transporter activity 4/430 188/18639 0.0212765957446809 0.922266204849085 0.633459965375609 0.779872881901104 GO:0051219 phosphoprotein binding 2/430 93/18639 0.021505376344086 0.93218304576144 0.636013964656086 0.781787965974435 GO:0005342 organic acid transmembrane transporter activity 4/430 189/18639 0.0211640211640212 0.917386489479513 0.63759286613804 0.782500335714867 GO:0016410 N-acyltransferase activity 2/430 94/18639 0.0212765957446809 0.922266204849085 0.641808447866935 0.7858610876177 GO:0001046 core promoter sequence-specific DNA binding 1/430 44/18639 0.0227272727272727 0.98514799154334 0.642338564591734 0.7858610876177 GO:0022843 voltage-gated monoatomic cation channel activity 3/430 143/18639 0.020979020979021 0.909367376809237 0.644415899103361 0.787172619341547 GO:0008276 protein methyltransferase activity 2/430 95/18639 0.0210526315789474 0.912558139534884 0.647530068521785 0.789744616281243 GO:0004896 cytokine receptor activity 2/430 96/18639 0.0208333333333333 0.903052325581395 0.653179096239307 0.794773198875015 GO:0008194 UDP-glycosyltransferase activity 3/430 145/18639 0.0206896551724138 0.89682437850842 0.653683192944457 0.794773198875015 GO:0030291 protein serine/threonine kinase inhibitor activity 1/430 46/18639 0.0217391304347826 0.942315470171891 0.658689223156357 0.799618080203763 GO:0005249 voltage-gated potassium channel activity 2/430 98/18639 0.0204081632653061 0.884622686283816 0.664260581524512 0.803888771767686 GO:0008170 N-methyltransferase activity 2/430 98/18639 0.0204081632653061 0.884622686283816 0.664260581524512 0.803888771767686 GO:0140938 histone H3 methyltransferase activity 1/430 47/18639 0.0212765957446809 0.922266204849085 0.666582711783408 0.804827605970754 GO:0015631 tubulin binding 8/430 385/18639 0.0207792207792208 0.90070673512534 0.667092102522374 0.804827605970754 GO:0004674 protein serine/threonine kinase activity 9/430 433/18639 0.0207852193995381 0.900966754390676 0.671230737568157 0.808574873101333 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/430 48/18639 0.0208333333333333 0.903052325581395 0.674294062575853 0.809773391099529 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/430 48/18639 0.0208333333333333 0.903052325581395 0.674294062575853 0.809773391099529 GO:0000510 H3-H4 histone complex chaperone activity 3/430 151/18639 0.0198675496688742 0.861188972739874 0.680441403630027 0.81217319975962 GO:0140584 chromatin extrusion motor activity 3/430 151/18639 0.0198675496688742 0.861188972739874 0.680441403630027 0.81217319975962 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 3/430 151/18639 0.0198675496688742 0.861188972739874 0.680441403630027 0.81217319975962 GO:0140849 ATP-dependent H2AZ histone chaperone activity 3/430 151/18639 0.0198675496688742 0.861188972739874 0.680441403630027 0.81217319975962 GO:0015616 DNA translocase activity 3/430 152/18639 0.0197368421052632 0.855523255813953 0.684748925337206 0.814830408114031 GO:0140674 ATP-dependent histone chaperone activity 3/430 152/18639 0.0197368421052632 0.855523255813953 0.684748925337206 0.814830408114031 GO:0061775 cohesin loader activity 3/430 153/18639 0.0196078431372549 0.849931600547196 0.689013061933666 0.817626427454717 GO:0015605 organophosphate ester transmembrane transporter activity 1/430 50/18639 0.02 0.86693023255814 0.689187026973325 0.817626427454717 GO:0005272 sodium channel activity 1/430 51/18639 0.0196078431372549 0.849931600547196 0.696376740158621 0.823660102030514 GO:0016830 carbon-carbon lyase activity 1/430 51/18639 0.0196078431372549 0.849931600547196 0.696376740158621 0.823660102030514 GO:0003713 transcription coactivator activity 5/430 256/18639 0.01953125 0.846611555232558 0.707033589053742 0.834952597875432 GO:0061630 ubiquitin protein ligase activity 7/430 353/18639 0.0198300283286119 0.8595625535279 0.709211597880789 0.834952597875432 GO:0140658 ATP-dependent chromatin remodeler activity 3/430 158/18639 0.0189873417721519 0.823035030909626 0.709685602122087 0.834952597875432 GO:0008146 sulfotransferase activity 1/430 53/18639 0.0188679245283019 0.817858709960509 0.710262184542781 0.834952597875432 GO:0141003 histone H2AX kinase activity 7/430 354/18639 0.019774011299435 0.857134410721324 0.711950496760734 0.834952597875432 GO:0051015 actin filament binding 4/430 209/18639 0.0191387559808612 0.829598308668076 0.713770533913856 0.834952597875432 GO:0017069 snRNA binding 1/430 54/18639 0.0185185185185185 0.802713178294574 0.716965469846053 0.834952597875432 GO:0050661 NADP binding 1/430 54/18639 0.0185185185185185 0.802713178294574 0.716965469846053 0.834952597875432 GO:0140463 chromatin-protein adaptor activity 1/430 54/18639 0.0185185185185185 0.802713178294574 0.716965469846053 0.834952597875432 GO:0003689 DNA clamp loader activity 3/430 160/18639 0.01875 0.812747093023256 0.71765402090698 0.834952597875432 GO:0015079 potassium ion transmembrane transporter activity 3/430 160/18639 0.01875 0.812747093023256 0.71765402090698 0.834952597875432 GO:0140996 histone H3 kinase activity 7/430 357/18639 0.0196078431372549 0.849931600547196 0.720063704574918 0.836513176086292 GO:0004222 metalloendopeptidase activity 2/430 110/18639 0.0181818181818182 0.788118393234672 0.724849029234328 0.840824873911821 GO:0035173 histone kinase activity 7/430 360/18639 0.0194444444444444 0.842848837209302 0.728021205687218 0.843255331439485 GO:0015081 sodium ion transmembrane transporter activity 3/430 164/18639 0.0182926829268293 0.79292399319342 0.733081292032481 0.846611580621582 GO:0140713 histone chaperone activity 3/430 164/18639 0.0182926829268293 0.79292399319342 0.733081292032481 0.846611580621582 GO:0008408 3'-5' exonuclease activity 1/430 58/18639 0.0172413793103448 0.747353648757017 0.742266511191343 0.855956816292815 GO:0016874 ligase activity 3/430 167/18639 0.0179640718562874 0.778679849603119 0.744210989900077 0.856937066311412 GO:0008514 organic anion transmembrane transporter activity 5/430 269/18639 0.0185873605947955 0.805697242154405 0.746745817282042 0.85858809926904 GO:0005201 extracellular matrix structural constituent 3/430 168/18639 0.0178571428571429 0.774044850498339 0.747837910219011 0.85858809926904 GO:0009055 electron transfer activity 2/430 116/18639 0.0172413793103448 0.747353648757017 0.751522336349118 0.860295306083859 GO:0015294 solute:monoatomic cation symporter activity 2/430 116/18639 0.0172413793103448 0.747353648757017 0.751522336349118 0.860295306083859 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/430 60/18639 0.0166666666666667 0.722441860465116 0.754057691141576 0.861937477611466 GO:0015179 L-amino acid transmembrane transporter activity 1/430 62/18639 0.0161290322580645 0.69913728432108 0.765310627509802 0.872247086150971 GO:0005244 voltage-gated monoatomic ion channel activity 3/430 173/18639 0.0173410404624277 0.75167361204463 0.765359447562993 0.872247086150971 GO:0008017 microtubule binding 5/430 276/18639 0.0181159420289855 0.785262891809909 0.766418895621798 0.872247086150971 GO:0005507 copper ion binding 1/430 63/18639 0.0158730158730159 0.688039867109634 0.770742959434805 0.872357068734208 GO:1901682 sulfur compound transmembrane transporter activity 1/430 63/18639 0.0158730158730159 0.688039867109634 0.770742959434805 0.872357068734208 GO:0004540 RNA nuclease activity 2/430 121/18639 0.0165289256198347 0.716471266576975 0.772023029668962 0.872357068734208 GO:0003735 structural constituent of ribosome 3/430 175/18639 0.0171428571428571 0.743083056478405 0.772086141293494 0.872357068734208 GO:0022832 voltage-gated channel activity 3/430 175/18639 0.0171428571428571 0.743083056478405 0.772086141293494 0.872357068734208 GO:0004536 DNA nuclease activity 1/430 64/18639 0.015625 0.677289244186047 0.776049835373814 0.875572076509649 GO:0005267 potassium channel activity 2/430 124/18639 0.0161290322580645 0.69913728432108 0.783603746300834 0.881174891943004 GO:0016500 protein-hormone receptor activity 1/430 67/18639 0.0149253731343284 0.646962860118015 0.791246303743742 0.881174891943004 GO:0042054 histone methyltransferase activity 1/430 67/18639 0.0149253731343284 0.646962860118015 0.791246303743742 0.881174891943004 GO:0008080 N-acetyltransferase activity 1/430 69/18639 0.0144927536231884 0.628210313447927 0.800801256385525 0.881174891943004 GO:0016279 protein-lysine N-methyltransferase activity 1/430 69/18639 0.0144927536231884 0.628210313447927 0.800801256385525 0.881174891943004 GO:0035591 signaling adaptor activity 2/430 129/18639 0.0155038759689922 0.67203893996755 0.801759629853585 0.881174891943004 GO:0016278 lysine N-methyltransferase activity 1/430 70/18639 0.0142857142857143 0.619235880398671 0.805413828262436 0.881174891943004 GO:0016782 transferase activity, transferring sulphur-containing groups 1/430 70/18639 0.0142857142857143 0.619235880398671 0.805413828262436 0.881174891943004 GO:0015276 ligand-gated monoatomic ion channel activity 3/430 186/18639 0.0161290322580645 0.69913728432108 0.806309945089093 0.881174891943004 GO:0005179 hormone activity 2/430 132/18639 0.0151515151515152 0.65676532769556 0.811993829670316 0.881174891943004 GO:0022834 ligand-gated channel activity 3/430 188/18639 0.0159574468085106 0.691699653636813 0.812045801365319 0.881174891943004 GO:0140597 protein carrier chaperone 3/430 188/18639 0.0159574468085106 0.691699653636813 0.812045801365319 0.881174891943004 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 4/430 243/18639 0.0164609053497942 0.713522825150732 0.815128901078116 0.881174891943004 GO:0004521 RNA endonuclease activity 1/430 73/18639 0.0136986301369863 0.593787830519274 0.818621926735477 0.881174891943004 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/430 73/18639 0.0136986301369863 0.593787830519274 0.818621926735477 0.881174891943004 GO:0046873 metal ion transmembrane transporter activity 8/430 450/18639 0.0177777777777778 0.770604651162791 0.818625101239578 0.881174891943004 GO:0004676 3-phosphoinositide-dependent protein kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0004711 ribosomal protein S6 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0035175 histone H3S10 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0035979 histone H2AXS139 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0044022 histone H3S28 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0044023 histone H4S1 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0044024 histone H2AS1 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0044025 histone H2BS14 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0072354 histone H3T3 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0072371 histone H2AS121 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0072518 Rho-dependent protein serine/threonine kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0140823 histone H2BS36 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0140855 histone H3S57 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0140995 histone H2A kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0140997 histone H4 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0140998 histone H2B kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:1990244 histone H2AT120 kinase activity 4/430 245/18639 0.0163265306122449 0.707698149027053 0.820049330095349 0.881174891943004 GO:0004677 DNA-dependent protein kinase activity 4/430 246/18639 0.016260162601626 0.70482132728304 0.822468904939863 0.881174891943004 GO:0140857 histone H3T45 kinase activity 4/430 246/18639 0.016260162601626 0.70482132728304 0.822468904939863 0.881174891943004 GO:0035064 methylated histone binding 1/430 74/18639 0.0135135135135135 0.585763670647392 0.822822754673846 0.881174891943004 GO:0035402 histone H3T11 kinase activity 4/430 247/18639 0.0161943319838057 0.701967799642218 0.824861619493088 0.881174891943004 GO:0035403 histone H3T6 kinase activity 4/430 247/18639 0.0161943319838057 0.701967799642218 0.824861619493088 0.881174891943004 GO:0019838 growth factor binding 2/430 136/18639 0.0147058823529412 0.637448700410397 0.824905741755073 0.881174891943004 GO:0044183 protein folding chaperone 1/430 75/18639 0.0133333333333333 0.577953488372093 0.82692650988474 0.881250680872214 GO:0004679 AMP-activated protein kinase activity 4/430 248/18639 0.0161290322580645 0.69913728432108 0.827227650627175 0.881250680872214 GO:0140104 molecular carrier activity 4/430 249/18639 0.0160642570281124 0.696329504062763 0.829567176911064 0.881602224953975 GO:0051536 iron-sulfur cluster binding 1/430 76/18639 0.0131578947368421 0.570348837209302 0.83093543041639 0.881602224953975 GO:0140034 methylation-dependent protein binding 1/430 76/18639 0.0131578947368421 0.570348837209302 0.83093543041639 0.881602224953975 GO:0003724 RNA helicase activity 1/430 77/18639 0.012987012987013 0.562941709453337 0.83485170283577 0.883363355838389 GO:0051540 metal cluster binding 1/430 77/18639 0.012987012987013 0.562941709453337 0.83485170283577 0.883363355838389 GO:0016758 hexosyltransferase activity 3/430 197/18639 0.0152284263959391 0.660099161846299 0.836108624420557 0.883499396654921 GO:0008186 ATP-dependent activity, acting on RNA 1/430 79/18639 0.0126582278481013 0.548690020606417 0.84241479926127 0.887766874591621 GO:0015370 solute:sodium symporter activity 1/430 79/18639 0.0126582278481013 0.548690020606417 0.84241479926127 0.887766874591621 GO:0000049 tRNA binding 1/430 80/18639 0.0125 0.541831395348837 0.846065749493902 0.890415970233502 GO:0015101 organic cation transmembrane transporter activity 1/430 81/18639 0.0123456790123457 0.535142118863049 0.849632306297481 0.892232785835681 GO:0016887 ATP hydrolysis activity 7/430 417/18639 0.0167865707434053 0.7276392839217 0.850071083312156 0.892232785835681 GO:0008168 methyltransferase activity 3/430 204/18639 0.0147058823529412 0.637448700410397 0.852947428903038 0.893715062608444 GO:0015293 symporter activity 2/430 146/18639 0.0136986301369863 0.593787830519274 0.853766113449701 0.893715062608444 GO:0005254 chloride channel activity 1/430 83/18639 0.0120481927710843 0.522247128047072 0.856519980236821 0.895400727003246 GO:0022836 gated channel activity 5/430 318/18639 0.0157232704402516 0.681548924967091 0.860812012981846 0.898687741553047 GO:0008094 ATP-dependent activity, acting on DNA 3/430 210/18639 0.0142857142857143 0.619235880398671 0.866161505428302 0.901913905741109 GO:0050660 flavin adenine dinucleotide binding 1/430 86/18639 0.0116279069767442 0.504029204975663 0.866265765096191 0.901913905741109 GO:0016757 glycosyltransferase activity 4/430 267/18639 0.0149812734082397 0.649385941991116 0.867357817398538 0.901913905741109 GO:0046906 tetrapyrrole binding 2/430 152/18639 0.0131578947368421 0.570348837209302 0.868933722670722 0.902354250465749 GO:0016651 oxidoreductase activity, acting on NAD(P)H 1/430 88/18639 0.0113636363636364 0.49257399577167 0.872393165986318 0.904746819824221 GO:0004386 helicase activity 2/430 155/18639 0.0129032258064516 0.559309827456864 0.875963876158542 0.906464104530719 GO:0016741 transferase activity, transferring one-carbon groups 3/430 215/18639 0.013953488372093 0.604835045970795 0.876364402464565 0.906464104530719 GO:0140097 catalytic activity, acting on DNA 5/430 336/18639 0.0148809523809524 0.645037375415282 0.890217555141566 0.919578292448346 GO:0016407 acetyltransferase activity 1/430 96/18639 0.0104166666666667 0.451526162790698 0.894226456363922 0.922502391743019 GO:0030594 neurotransmitter receptor activity 1/430 97/18639 0.0103092783505155 0.446871253895948 0.896679275420359 0.922893174639997 GO:0015103 inorganic anion transmembrane transporter activity 2/430 165/18639 0.0121212121212121 0.525412262156448 0.896962587357647 0.922893174639997 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/430 167/18639 0.0119760479041916 0.519119899735413 0.900744803291075 0.924983294533174 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 3/430 229/18639 0.0131004366812227 0.567858230933279 0.901356645886094 0.924983294533174 GO:0015171 amino acid transmembrane transporter activity 1/430 102/18639 0.00980392156862745 0.424965800273598 0.908117871902506 0.93070195510427 GO:0005253 monoatomic anion channel activity 1/430 103/18639 0.00970873786407767 0.420839918717543 0.910249247803781 0.93166687716387 GO:0004497 monooxygenase activity 1/430 106/18639 0.00943396226415094 0.408929354980255 0.916351932240684 0.934376793034741 GO:0008013 beta-catenin binding 1/430 106/18639 0.00943396226415094 0.408929354980255 0.916351932240684 0.934376793034741 GO:0045182 translation regulator activity 5/430 356/18639 0.0140449438202247 0.608799320616671 0.916476854470857 0.934376793034741 GO:0015108 chloride transmembrane transporter activity 1/430 121/18639 0.00826446280991736 0.358235633288487 0.941187475344512 0.958322227821525 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 1/430 122/18639 0.00819672131147541 0.355299275638582 0.942553140405634 0.958466375243652 GO:0140098 catalytic activity, acting on RNA 5/430 387/18639 0.0129198966408269 0.560032449972958 0.946319111030583 0.960622867259983 GO:0016829 lyase activity 2/430 200/18639 0.01 0.43346511627907 0.947127526851477 0.960622867259983 GO:0004519 endonuclease activity 1/430 127/18639 0.0078740157480315 0.34131111518037 0.948921248234704 0.961155478608754 GO:0001653 peptide receptor activity 1/430 128/18639 0.0078125 0.338644622093023 0.950107714486815 0.961155478608754 GO:0004518 nuclease activity 2/430 209/18639 0.00956937799043062 0.414799154334038 0.95563646273756 0.965501097191625 GO:0140767 enzyme-substrate adaptor activity 1/430 139/18639 0.00719424460431655 0.311845407395014 0.961476927439281 0.97015004405278 GO:0015291 secondary active transmembrane transporter activity 3/430 287/18639 0.0104529616724739 0.453099424681955 0.963216466576364 0.970297340966205 GO:0020037 heme binding 1/430 142/18639 0.00704225352112676 0.30525712414019 0.964101317077532 0.970297340966205 GO:0008509 monoatomic anion transmembrane transporter activity 1/430 149/18639 0.00671140939597315 0.290916185422194 0.969551912898436 0.974530356610366 GO:0042393 histone binding 2/430 247/18639 0.00809716599190283 0.350983899821109 0.979152087822411 0.982918057390959 GO:0030371 translation repressor activity 3/430 329/18639 0.00911854103343465 0.395256944935322 0.982720236112733 0.985236805219296 GO:0016853 isomerase activity 1/430 180/18639 0.00555555555555556 0.240813953488372 0.985327451409898 0.985669246517636 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1/430 181/18639 0.00552486187845304 0.239483489656945 0.985669246517636 0.985669246517636