category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	39/852	180/9376	2.38435054773083	AKT3/B2M/BST2/OAS2/HLA-DRA/TAP1/HLA-A/TAP2/TAB2/STAT1/BIRC2/TBK1/TRAF5/TAPBP/MAP3K7/TICAM1/HLA-DRB5/HLA-DMA/TYK2/SRC/EIF2B1/EIF2B3/APAF1/NECTIN2/BAD/EIF2B5/RELA/CASP3/ITGA5/TSC2/SRSF6/TNFRSF1A/SP100/TRAF2/AKT2/CHUK/BAK1/OAS1/PPP1CA	5.92879676364658
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	42/852	205/9376	2.25462040535898	VIM/AKT3/B2M/CCND2/OAS2/ISG15/CDK6/CIR1/HLA-DRA/TAP1/SAP30L/HLA-A/TAP2/TAB2/STAT1/TBK1/TRAF5/TAPBP/MAP3K7/HLA-DRB5/HLA-DMA/SNW1/LYN/TYK2/PSMC5/PSMC6/APAF1/RELA/PSMD13/CASP3/CDKN1B/MAP2K4/PSMD14/TRAF2/CCNE2/AKT2/CHUK/BAK1/PSMC2/OAS1/PSMD3/PSMD6	5.74201926902376
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	41/852	203/9376	2.22262309489119	COL1A1/IGF1/COL6A3/PDGFRA/COL6A1/LAMA2/COL6A2/FN1/PDGFRB/AKT3/PIP5K1B/MYL9/HGF/PRKCA/COL4A2/COL4A1/LAMB1/CCND2/THBS2/COL4A6/TNXB/ITGB8/ACTB/LAMC3/COL1A2/BIRC2/CRK/FYN/SRC/PIP5K1C/FLNA/PPP1R12B/BAD/CRKL/EMP1/ITGA5/PARVA/RAC3/MAPK3/AKT2/PPP1CA	5.56760777257035
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	58/852	333/9376	1.91673363504349	COL1A1/COL6A3/COL6A1/LAMA2/COL6A2/FN1/PDGFRB/AKT3/COL4A2/COL4A1/LAMB1/WNT4/MX1/CCND2/THBS2/ISG15/COL4A6/MX2/TNXB/CDK6/ITGB8/LAMC3/COL1A2/HLA-A/STAT1/PPP2R1A/TBK1/WNT5A/TICAM1/MAML1/UBR4/PPP2CA/WNT2/TYK2/AXIN1/MAP2K2/NRAS/TCIRG1/BAD/RELA/CASP3/ITGA5/TSC2/RFNG/CDKN1B/TNFRSF1A/PPP2R5C/UBE3A/CCNE2/MAPK3/AKT2/PPP2R5D/CHUK/TADA3/BAK1/PPP2R2A/BCAP31/HES4	5.38508710302185
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	27/852	108/9376	2.75117370892019	RANBP17/MAGOH/KPNA4/AHCTF1/NUP153/CASC3/PYM1/UPF3A/SNUPN/NUP205/ACIN1/NUP43/RNPS1/NUP62/RAN/SEC13/KPNA1/XPO5/NCBP2/XPO7/TNPO3/RAE1/PNN/TMEM33/KPNA3/IPO7/NUP35	5.78671120322934
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	44/852	238/9376	2.03448139819308	C1R/CFD/NRP1/C1S/PRKCA/RPLP1/MASP1/MX1/OAS2/ISG15/MX2/RPS18/TAB2/RPL18/STAT1/RPL39/TBK1/RPL13/RPS2/MAP3K7/RPS23/RPS27/RPS4X/TYK2/RPS7/RPS28/RPS19/FOS/RPL3/RPS14/RELA/RPS15A/TNFRSF1A/RPL10A/RPL30/RPL9/RPL37A/MAPK3/CHUK/RPS27A/OAS1/RPS29/RSL24D1/RPL23A	5.11056954316899
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	24/852	103/9376	2.56420073841105	MAGOH/PPP2R1A/DAZAP1/CASC3/PCF11/TARDBP/PYM1/UPF3A/PPP2CA/ETF1/HBS1L/ACIN1/RNPS1/CPSF2/CPSF1/NCBP2/PPP2R5C/PABPC5/PNN/PPP2R5D/PPP2R2A/PELO/PPP1CA/NUDT21	5.04643500400849
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/852	101/9376	2.50601961604611	COL3A1/COL1A1/FN1/AKT3/MMP2/PRKCA/COL4A2/COL4A1/COL4A6/COL1A2/STAT1/PLCB1/TGFBR2/SERPINE1/PRKCD/NRAS/RELA/PLCB3/CASP3/CDKN1B/MAPK3/AKT2/SMAD4	4.81080851997809
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/852	21/9376	4.71629778672032	CHSY3/XYLT1/UST/CHST11/CHST7/CHST3/DSEL/CSGALNACT2/B3GALT6	5.38991570598577
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	40/852	233/9376	1.88921799754176	COL3A1/COL1A1/COL6A3/NID1/DCN/COL6A1/LAMA2/VIM/COL6A2/COL5A2/FN1/COL5A1/ELN/FBN1/FBLN2/MYL9/COL4A2/COL4A1/LMOD1/TPM2/THBS2/COL4A6/FBLN1/ITGB8/ACTB/COL1A2/ANK3/FHL1/FMN2/SYNPO2/COL5A3/ATP1B3/SGCB/FMNL1/TTN/LBR/SNTB2/ITGA5/CSRP1/TMEM43	4.34535797436172
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	30/852	156/9376	2.11628746840014	AKT3/MX1/OAS2/MX2/OCLN/CDK6/IFIT1/STAT1/PPP2R1A/TBK1/TICAM1/YWHAG/PPP2CA/TYK2/MAP2K2/NRAS/APAF1/BAD/RELA/CASP3/TNFRSF1A/LDLR/TRAF2/MAPK3/AKT2/CHUK/BAK1/PPP2R2A/OAS1/NR1H3	4.44484481695511
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/852	93/9376	2.48493109192791	SNAI2/CTNNA2/MYL9/CTNNA3/ACTB/YES1/PTPN1/LEF1/WASL/MAP3K7/TGFBR2/FYN/RADIL/SRC/NECTIN2/SMURF2/CCM2/RAC3/HEG1/MAPK3/SMAD4	4.54974770755839
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/852	93/9376	2.48493109192791	LAMA2/FN1/AKT3/COL4A2/COL4A1/LAMB1/COL4A6/CDK6/LAMC3/BIRC2/TRAF5/APAF1/RELA/CASP3/CDKN1B/TRAF2/MAX/CCNE2/AKT2/CHUK/BAK1	4.54974770755839
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/852	204/9376	1.94200497100249	COL1A1/IGF1/HPSE2/DCN/TWIST2/FN1/TIMP3/AKT3/MMP2/LUM/HGF/HOXD10/PRKCA/WNT4/FGF2/ERBB4/ACTB/COL1A2/ANK3/ITPR2/WNT5A/ARHGEF1/ESR1/WNT2/SRC/MAP2K2/NRAS/FLNA/PPP1R12B/CASP3/ITGA5/SMO/MAPK3/AKT2/PPP1CA/RRAS	4.30051008383079
NA	NA	hsa04518	Integrin signaling	29/852	154/9376	2.07231266386196	COL1A1/IGF1/COL6A3/PDGFRA/COL6A1/LAMA2/COL6A2/FN1/PDGFRB/FBN1/AKT3/HGF/COL4A2/COL4A1/LAMB1/CCND2/THBS2/COL4A6/TNXB/ITGB8/ACTB/LAMC3/COL1A2/SRC/FLNA/ITGA5/PARVA/RAC3/AKT2	4.24182699389301
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	22/852	103/9376	2.35051734354346	COL3A1/COL1A1/MME/COL6A3/COL6A1/COL6A2/COL5A2/COL5A1/COL15A1/ELN/SLC8A1/COL4A2/COL4A1/COL4A6/COL1A2/COL5A3/COL23A1/ATP1B3/SLC1A5/COL7A1/SLC3A2/COL18A1	4.35704818992824
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/852	130/9376	2.11628746840014	COL3A1/COL1A1/AKT3/MMP2/ADCY3/ADCY1/PRKCA/COL4A2/COL4A1/COL4A6/ARRB1/COL1A2/PLCB1/TGFBR2/SRC/FOS/MAP2K2/NRAS/ADCY5/RELA/PLCB3/MAP2K4/GNG2/MAPK3/AKT2	4.05186060449347
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	26/852	138/9376	2.07334830237463	FN1/AKT3/PIP5K1B/ACTB/GIT2/TAB2/WIPF1/TBK1/WASL/MAP3K7/ARHGEF1/TICAM1/CRK/SRC/FOS/PIP5K1C/MAP2K2/CRKL/RELA/ITGA5/MAP2K4/RAC3/TRAF2/MAPK3/AKT2/CHUK	4.01582660901288
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	37/852	227/9376	1.79371677938409	PDGFRA/AKT3/B2M/ADCY3/ADCY1/PRKCA/AKAP13/CDK6/TAP1/HLA-A/TAP2/ITPR2/TBK1/TRAF5/TAPBP/ARHGEF1/PLCB1/CRK/SRC/MAP2K2/NRAS/ADCY5/CRKL/RELA/PLCB3/CASP3/TSC2/TNFRSF1A/CXCL12/GNG2/RAC3/TRAF2/MAPK3/AKT2/CHUK/BAK1/ARHGEF11	3.82714918237767
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	28/852	157/9376	1.96262073502587	SNAI2/GDF7/CTNNA2/CTNNA3/WNT4/CCND2/FRMD6/ACTB/PPP2R1A/BIRC2/WNT5A/CSNK1E/NF2/LATS1/LEF1/TGFBR2/SERPINE1/YWHAG/LATS2/PPP2CA/WNT2/AXIN1/TP53BP2/SMAD7/FBXW11/SMAD4/PPP2R2A/PPP1CA	3.84544714121818
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/852	65/9376	2.53954496208017	AKT3/PRKCA/TRPC4/CACNA1D/CACNA1C/CACNA1G/GABBR1/ARRB1/ITPR2/PLCB1/MAP2K2/NRAS/PLCB3/MAPK3/AKT2	3.93762729619877
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/852	60/9376	2.56776212832551	IGF1/PRKG1/PRKCA/GRIA1/ITPR2/PPP2R1A/PLCB1/GRIA3/LYN/PPP2CA/MAP2K2/NRAS/PLCB3/MAPK3	3.85145448158099
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/852	173/9376	1.84471763141469	AKT3/PRKCA/MX1/OAS2/MX2/CDK6/HLA-DRA/ACTB/STAT1/TBK1/TICAM1/HLA-DRB5/HLA-DMA/TYK2/MAP2K2/APAF1/RELA/CASP3/KPNA1/TNFRSF1A/DNAJC3/RAE1/MAPK3/AKT2/CHUK/RAB11A/BAK1/CALCOCO2/OAS1	3.54530509438728
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	34/852	214/9376	1.74840945987451	AKT3/B2M/PRKCA/BST2/TAP1/HLA-A/TAP2/TAB2/ITPR2/TBK1/TRAF5/TAPBP/MAP3K7/CRK/CUL4A/FOS/MAP2K2/NRAS/BAD/CRKL/RELA/CASP3/AP1G1/CUL4B/TNFRSF1A/FBXW11/RBX1/GNG2/RAC3/TRAF2/MAPK3/AKT2/CHUK/BAK1	3.50134355601419
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	24/852	134/9376	1.97099011982342	CALCRL/EDNRA/PRKG1/RAMP1/CALD1/ADCY3/MYL9/ADCY1/PRKCA/CACNA1D/PRKCH/CACNA1C/PPP1R14A/ITPR2/ARHGEF1/PLCB1/PRKCD/MAP2K2/PPP1R12B/ADCY5/PLCB3/MAPK3/ARHGEF11/PPP1CA	3.57905146173547
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/852	89/9376	2.22566861845229	PDGFRA/PRKG1/PDGFRB/ADCY3/ADCY1/PRKCA/TUBB6/ITPR2/PLCB1/SRC/GJA1/MAP2K2/TUBA4A/NRAS/ADCY5/PLCB3/MAP2K5/MAPK3	3.67294193195527
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	51/852	362/9376	1.55038518403237	COL1A1/IGF1/COL6A3/PDGFRA/COL6A1/LAMA2/COL6A2/FN1/PDGFRB/MAGI2/FGF10/AKT3/HGF/PRKCA/COL4A2/COL4A1/LAMB1/FGF2/CCND2/THBS2/COL4A6/TNXB/CDK6/PRLR/ERBB4/ITGB8/LAMC3/COL1A2/PPP2R1A/IL2RB/FGF7/GHR/YWHAG/PPP2CA/MAP2K2/NRAS/BAD/RELA/ITGA5/TSC2/STK11/CDKN1B/PPP2R5C/PIK3AP1/GNG2/CCNE2/MAPK3/AKT2/PPP2R5D/CHUK/PPP2R2A	3.37633832087214
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	25/852	144/9376	1.91053729786124	RORA/AKT3/PRKCA/GRIA1/ATXN1/ITPR2/ULK2/PLCB1/NOP56/GRIA3/ULK1/PSMC5/PSMC6/PSMD13/PLCB3/OMA1/VDAC3/PSMD14/TRAF2/AKT2/PSMC2/PSMD3/PSMD6/GTF2B/PSMA5	3.48108640752974
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/852	56/9376	2.55466130114017	ST6GAL2/TUSC3/MAN1B1/MAGT1/DPM1/ALG14/MAN1A1/ALG8/MGAT2/DDOST/ALG9/ALG11/ALG13	3.68897371328633
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/852	137/9376	1.92782975223604	AKT3/PTPN13/ACTB/ITPR2/BIRC2/CAPN1/FOS/MAP2K2/CTSC/TUBA4A/NRAS/APAF1/BAD/RELA/CASP3/AIFM1/TNFRSF1A/GZMB/DFFA/TRAF2/MAPK3/AKT2/CHUK/BAK1	3.45859580031227
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/852	77/9376	2.28668983598561	AKT3/CDK6/TGFBR2/CRK/MAP2K2/NRAS/BAD/CRKL/RELA/CDKN1B/MAPK3/AKT2/CHUK/CTBP1/BAK1/SMAD4	3.58413883498227
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/852	99/9376	2.11201214018115	PDGFRA/DGKB/PDGFRB/AKT3/PIP5K1B/PLPP3/SLC22A3/PRKCA/PCYT1A/FOS/PIP5K1C/MAP2K2/NRAS/PLPP1/LYPLA1/TSC2/RAC3/MAPK3/AKT2	3.51647118203952
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	24/852	138/9376	1.91385997142274	IGF1/ADCY3/ADCY1/PGR/ANAPC4/AR/ITPR2/PPP2R1A/YWHAG/CPEB2/PPP2CA/ANAPC10/CPEB3/ANAPC15/ADCY5/PPP2R5C/FBXW11/RBX1/CCNE2/MAPK3/PPP2R5D/REC8/ANAPC13/PPP1CA	3.4191167788052
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	17/852	86/9376	2.1753466535648	LAMA2/CACNA2D1/CTNNA2/SLC8A1/CTNNA3/CACNA1D/CACNA1C/CACNB2/ITGB8/ACTB/LEF1/RYR2/SGCB/CDH2/GJA1/SNTB2/ITGA5	3.46171299855698
Genetic Information Processing	Translation	hsa03010	Ribosome	34/852	222/9376	1.68540371357273	RPLP1/RPS18/RPL18/RPL39/RPL13/RPS2/RPS23/MRPL39/RPS27/MRPS34/RPS4X/DAP3/RPS7/MRPS35/RPS28/RPS19/MRPL42/MRPL16/MRPS25/MRPL12/RPL3/RPS14/MRPS5/RPS15A/RPL10A/RPL30/RPL9/RPL37A/RPS27A/RPS29/RSL24D1/RPL23A/MRPS11/MRPS28	3.26739169917324
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	37/852	250/9376	1.62869483568075	PDGFRA/PIP5K1B/RAB31/EHD2/VPS4A/ARRB1/GIT2/HLA-A/WIPF1/RABEP1/KIF5C/CHMP6/WASL/RAB11FIP3/IL2RB/PSD3/TGFBR2/ZFYVE9/SRC/VPS45/PIP5K1C/ARFGAP2/SNX2/SNX4/HGS/RUFY2/SH3GLB2/SMURF2/IST1/RAB5C/LDLR/SNX1/RAB11A/ARF4/SH3KBP1/WASHC1/GBF1	3.1853222856851
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/852	73/9376	2.26123866486591	IGF1/PDGFRA/PDGFRB/FGF10/AKT3/HGF/FGF2/CDK6/FGF7/MAP2K2/NRAS/BAD/MAPK3/AKT2/BAK1	3.42003783656922
Organismal Systems	Immune system	hsa04611	Platelet activation	22/852	126/9376	1.92145465384902	COL3A1/COL1A1/PRKG1/AKT3/ADCY3/ADCY1/ACTB/COL1A2/ITPR2/SNAP23/ARHGEF1/PLCB1/GP1BB/LYN/FYN/SRC/ADCY5/APBB1IP/PLCB3/MAPK3/AKT2/PPP1CA	3.29209295253531
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/852	89/9376	2.1020203618716	COL1A1/COL6A3/COL6A1/LAMA2/COL6A2/FN1/COL4A2/COL4A1/LAMB1/THBS2/COL4A6/TNXB/ITGB8/LAMC3/COL1A2/GP1BB/ITGA5	3.30240714011093
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	20/852	112/9376	1.96512407780013	LAMA2/AKT3/LAMB1/HLA-DRA/LAMC3/TAB2/STAT1/BIRC2/MAP3K7/HLA-DRB5/HLA-DMA/TYK2/BAD/RELA/CASP3/TNFRSF1A/LDLR/MAPK3/AKT2/CHUK	3.2484531204228
Human Diseases	Infectious disease: viral	hsa05162	Measles	23/852	136/9376	1.86108809721072	AKT3/MX1/CCND2/OAS2/MX2/CDK6/TAB2/STAT1/TBK1/MAP3K7/IL2RB/TYK2/FOS/APAF1/BAD/RELA/CASP3/CDKN1B/CCNE2/AKT2/CHUK/BAK1/OAS1	3.19789919492096
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	28/852	178/9376	1.73107559212956	APCDD1/SFRP4/MCC/SERPINF1/DKK1/PRICKLE1/PRKCA/WNT4/SFRP1/CCND2/ROR1/WNT5A/CSNK1E/LEF1/MAP3K7/CTNNBIP1/PLCB1/LZTS2/WNT2/SOX17/AXIN1/TLE1/PLCB3/FBXW11/RBX1/RAC3/CTBP1/SMAD4	3.1132163189545
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/852	122/9376	1.89425075040406	IGF1/AKT3/ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/ITPR2/STAT1/PLCB1/CRK/GHR/FOS/MAP2K2/NRAS/ADCY5/CRKL/PLCB3/MAP2K4/MAPK3/AKT2	3.14309998149688
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/852	163/9376	1.75535009648895	AKT3/PRKCA/TAB2/STAT1/TBK1/MAP3K7/TICAM1/TGFBR2/TYK2/SRC/PCNA/FOS/MAP2K2/NRAS/APAF1/BAD/RELA/CASP3/VDAC3/MAP2K4/CCNE2/MAPK3/AKT2/CHUK/SMAD4/DDX3X	3.07556755457812
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/852	224/9376	1.62122736418511	AKT3/B2M/NRP1/ADCY3/ADCY1/CCND2/IL15/ANAPC4/HLA-DRA/HLA-A/IL2RB/TGFBR2/HLA-DRB5/HLA-DMA/ANAPC10/FOS/MAP2K2/NRAS/ANAPC15/ADCY5/RAN/RELA/TNFRSF1A/VDAC3/MAP2K4/CCNE2/MAPK3/AKT2/CHUK/CRTC1/SMAD4/ANAPC13/GPS2	2.97509128686698
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/852	157/9376	1.75233994198738	AKT3/CACNA1D/CCND2/CDK6/HLA-A/ITPR2/TRAF3IP2/MRE11/CAPN1/TGFBR2/SERPINE1/ZFP36L2/MAP2K2/NRAS/RELA/TSC2/VDAC3/FBXW11/RBBP4/CCNE2/MAPK3/AKT2/PPP1CA/RRAS/E2F5	3.00542401994061
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/852	133/9376	1.82032546154118	AKT3/PRKCA/CACNA1D/CACNA1C/GRIA1/ARRB1/ITPR2/PPP2R1A/KIF5C/PLCB1/GRIA3/PPP2CA/FOS/ADCY5/PLCB3/MAOB/PPP2R5C/GNG2/AKT2/PPP2R5D/PPP2R2A/PPP1CA	3.01223777550382
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/852	125/9376	1.84878873239437	AKT3/PRKCA/S1PR3/PPP2R1A/PLCB1/FYN/PPP2CA/MAP2K2/NRAS/CERS5/RELA/PLCB3/TNFRSF1A/PPP2R5C/RAC3/TRAF2/MAPK3/AKT2/PPP2R5D/PPP2R2A/BDKRB2	3.02025760667454
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	61/852	480/9376	1.39851330203443	SNCAIP/DKK1/PRKCA/CACNA1D/WNT4/CACNA1C/TUBB6/GRIA1/COX7A1/GPX8/NDUFS2/ATXN1/PRNP/ITPR2/ULK2/TBK1/WNT5A/UQCRC2/CSNK1E/KIF5C/RYR2/CAPN1/TARDBP/PLCB1/NDUFA8/GRIA3/ULK1/MFN2/WNT2/AXIN1/PSMC5/NDUFS4/PSMC6/MAP2K2/TUBA4A/NRAS/DNALI1/APAF1/SDHD/BAD/DNAL4/RELA/PSMD13/PLCB3/CASP3/ATP5PB/TNFRSF1A/VDAC3/PSMD14/CAT/VCP/TRAF2/MAPK3/UBE2J2/BAK1/RPS27A/PSMC2/PSMD3/NDUFB1/PSMD6/PSMA5	2.83367324054424
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/852	103/9376	1.92315055380829	AKT3/ADCY1/PPP2R1A/TICAM1/PLCB1/TGFBR2/SERPINE1/PPP2CA/FOS/RELA/PLCB3/TNFRSF1A/MAP2K4/MAPK3/AKT2/CHUK/PPP2R2A/BDKRB2	2.97827456176775
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/852	103/9376	1.92315055380829	COL3A1/COL1A1/LAMA2/FN1/ADCY1/PRKCA/COL4A2/COL4A1/LAMB1/COL4A6/LAMC3/COL1A2/PLCB1/RAB7B/RELA/PLCB3/CASP3/RAB5C	2.97827456176775
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/852	44/9376	2.50106700810926	TUSC3/MAN1B1/MAGT1/ALG14/MAN1A1/MGAT2/DDOST/ALG9/ALG11/ALG13	3.15517002938088
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	24/852	154/9376	1.71501737698921	CACNA2D1/AKT3/SLC8A1/ADCY3/ADCY1/PRKCA/CACNA1D/TPM2/CACNA1C/CACNB2/PPP2R1A/ATP1B3/RYR2/PLCB1/PPP2CA/ADCY5/PLCB3/PPP2R5C/MAPK3/AKT2/PPP2R5D/ATP2B1/PPP2R2A/PPP1CA	2.82844744171168
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	24/852	154/9376	1.71501737698921	CACNA2D1/ADCY3/MYL9/ADCY1/PRKCA/CACNA1D/CACNA1C/CACNB2/ACTB/ITPR2/RYR2/PLCB1/SRC/CAMK4/FOS/MAP2K2/NRAS/PPP1R12B/ADCY5/PLCB3/MAP2K5/MAPK3/KCNJ2/PPP1CA	2.82844744171168
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/852	105/9376	1.88651911468813	IGF1/LAMA2/CACNA2D1/SLC8A1/ADCY3/ADCY1/CACNA1D/TPM2/CACNA1C/CACNB2/ITGB8/ACTB/RYR2/SGCB/TTN/ADCY5/SNTB2/ITGA5	2.88803982793468
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	50/852	388/9376	1.41813077779391	MME/APOE/AKT3/LRP1/DKK1/CACNA1D/WNT4/CACNA1C/TUBB6/COX7A1/NDUFS2/SLC39A14/ITPR2/ULK2/WNT5A/UQCRC2/CSNK1E/KIF5C/CAPN1/PLCB1/NDUFA8/ULK1/WNT2/AXIN1/PSMC5/NDUFS4/PSMC6/MAP2K2/TUBA4A/NRAS/APAF1/SDHD/BAD/RELA/PSMD13/PLCB3/CASP3/ATP5PB/TNFRSF1A/VDAC3/PSMD14/TRAF2/MAPK3/AKT2/CHUK/PSMC2/PSMD3/NDUFB1/PSMD6/PSMA5	2.65937867725388
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/852	115/9376	1.8181669728516	AKT3/ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/ITPR2/PLCB1/KCNQ3/FYN/CAMK4/FOS/NRAS/ADCY5/PLCB3/GNG2/MAPK3/AKT2/KCNJ2	2.79090875071731
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	24/852	158/9376	1.67159921554644	CCND2/ANAPC4/CDK6/PPP2R1A/ORC4/YWHAG/MCM5/PPP2CA/ANAPC10/SFN/PCNA/ANAPC15/RAD21/MCM4/ORC2/CDKN1B/PPP2R5C/RBX1/CCNE2/PPP2R5D/SMAD4/ANAPC13/TFDP2/E2F5	2.69156013218053
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/852	93/9376	1.89328083194508	MMP2/ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/ITPR2/PLCB1/PRKCD/SRC/MAP2K2/NRAS/ADCY5/PLCB3/MAP2K4/MAPK3	2.73696364729715
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/852	70/9376	2.04372904091214	AKT3/HGF/CRK/MAP2K2/NRAS/BAD/CRKL/PRCC/EGLN2/RBX1/EGLN1/MAPK3/AKT2	2.7710156495004
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	34/852	248/9376	1.50870816295623	AKT3/MYL9/TUBB6/ACTB/TAB2/KPNA4/BIRC2/KIF5C/LEF1/WASL/MAP3K7/VPS16/RAB7B/EXOC7/FOS/MAP2K2/TUBA4A/FLNA/EXOC2/RELA/CASP3/RAB5C/GSDMD/KPNA1/TNFRSF1A/MAP2K4/TRAF2/MAPK3/AKT2/CHUK/BAK1/BRK1/KPNA3/RRAS	2.56679063648403
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/852	196/9376	1.57209926224011	AKT3/FGF2/CDK6/HLA-A/ITPR2/STAT1/CLEC2B/TBK1/ATG3/LEF1/TICAM1/LYN/TYK2/SRC/FOS/MAP2K2/NRAS/RELA/CASP3/TNFRSF1A/MAP2K4/GNG2/TRAF2/MAPK3/AKT2/CHUK/BAK1/RPS27A	2.55894998632306
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/852	71/9376	2.01494412484295	AKT3/CCND2/PRLR/STAT1/ESR1/SRC/FOS/MAP2K2/NRAS/RELA/SOCS7/MAPK3/AKT2	2.71391870703091
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/852	80/9376	1.92582159624413	IGF1/PDGFRA/PDGFRB/AKT3/AXL/HGF/PRKCA/FGF2/SRC/MAP2K2/NRAS/BAD/MAPK3/AKT2	2.62910516401503
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/852	105/9376	1.78171249720546	RHOT1/TBK1/RAB7B/ULK1/MFN2/RHOT2/SRC/NRAS/SMURF2/RELA/RAB5C/TOMM70/VCP/TRAF2/RPS27A/CALCOCO2/RRAS	2.54660817631422
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/852	97/9376	1.81520739557621	PRKG1/ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/CACNA1G/GRIA1/RYR2/PLCB1/GRIA3/FOS/ADCY5/PLCB3/GNG2/MAPK3	2.55145025711321
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/852	122/9376	1.71384591703225	AKT3/PRKCA/WNT4/ACTB/STAT1/MED24/ATP1B3/PLCB1/HDAC3/ESR1/SRC/MAP2K2/NRAS/BAD/PLCB3/MED27/TSC2/MAPK3/AKT2	2.50901560619533
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/852	300/9376	1.4306103286385	IGF1/PDGFRA/CACNA2D1/PDGFRB/FGF10/AKT3/HGF/PRKCA/CACNA1D/FGF2/CACNA1C/CACNA1G/CACNB2/ERBB4/ARRB1/TAB2/MAP3K7/TGFBR2/CRK/FGF7/FOS/MAP2K2/NRAS/FLNA/DUSP1/CRKL/RELA/CASP3/TNFRSF1A/MAP2K4/MAP2K5/RAC3/PPM1A/TRAF2/MAX/MAPK3/AKT2/CHUK/RRAS	2.3965226692374
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/852	106/9376	1.76490388874125	IGF1/ZEB1/PDGFRA/PDGFRB/AKT3/PLAT/AR/LEF1/MAP2K2/NRAS/BAD/RELA/CDKN1B/CCNE2/MAPK3/AKT2/CHUK	2.50382314392368
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	28/852	201/9376	1.53299231541821	IGF1/ZEB1/RUNX1T1/HOXA10/WT1/HOXA11/CCND2/PLAT/MAF/HOXA9/BIRC2/IL2RB/TGFBR2/GRIA3/ATF1/CCNT1/TAF15/RELA/CDKN1B/EYA1/PRCC/DOT1L/SS18L1/GZMB/REL/MAX/BAK1/PBX1	2.41490279860768
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/852	98/9376	1.79668487113155	DGKB/INPP4B/PIP5K1B/PRKCA/ITPR2/CDS1/PIP4P1/PLCB1/PI4K2B/PIP5K1C/ITPKC/PLCB3/INPPL1/MTM1/INPP4A/IMPA2	2.50643322519718
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/852	98/9376	1.79668487113155	ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/CACNA1G/ITPR2/ATP1B3/PLCB1/ATF1/CAMK4/ADCY5/PLCB3/LDLR/ATP2B1/DAGLA	2.50643322519718
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/852	140/9376	1.65070422535211	AKT3/SLC8A1/ADCY3/ADCY1/PLAT/ITPR2/RYR2/PLCB1/SERPINE1/TFAM/CAMK4/MAP2K2/NRAS/ADCY5/PLCB3/GNG2/MAPK3/AKT2/SMAD4/PDE3B/RRAS	2.45238921542832
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/852	166/9376	1.59104021720686	EDNRA/PRKG1/AKT3/SLC8A1/ADCY3/MYL9/ADCY1/ADRA2C/CACNA1D/CACNA1C/ITPR2/ATP1B3/PLCB1/MAP2K2/BAD/ADCY5/PLCB3/VDAC3/MAPK3/AKT2/ATP2B1/PPP1CA/PDE3B/BDKRB2	2.42898580809002
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/852	149/9376	1.62485427104011	PDGFRA/DGKB/PDGFRB/AKT3/PIP5K1B/PLPP3/ADCY3/ADCY1/PRKCA/GRM7/PLCB1/FYN/PIP5K1C/MAP2K2/NRAS/PLPP1/ADCY5/PLCB3/TSC2/MAPK3/AKT2/RRAS	2.43066625464634
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/852	158/9376	1.60194924823201	IGF1/AKT3/PRKCA/WNT4/ULK2/WNT5A/RRAGC/ULK1/STRADA/WNT2/SESN2/MAP2K2/NRAS/LAMTOR5/TSC2/STK11/SEC13/TNFRSF1A/SLC3A2/RICTOR/MAPK3/AKT2/CHUK	2.41242479239506
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/852	59/9376	2.05172276597438	AKT3/CTNNA2/CTNNA3/LEF1/AXIN1/MAP2K2/NRAS/BAD/MAPK3/AKT2/BAK1	2.56196355867983
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/852	67/9376	1.97099011982342	ADCY1/PRKCA/CACNA1C/GRIA1/ITPR2/PLCB1/CAMK4/MAP2K2/NRAS/PLCB3/MAPK3/PPP1CA	2.52164770579185
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	14/852	83/9376	1.85621358674133	AUTS2/SFMBT2/PCGF3/RBBP7/USP16/ASXL2/PHC2/SUZ12/LCOR/RBBP4/FBRSL1/KDM2B/MAX/OGT	2.47700514001233
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	21/852	142/9376	1.62745487006546	ANAPC4/KLHL13/PPIL2/TRIM37/BIRC2/PIAS3/CUL4A/ANAPC10/SAE1/KLHL9/ANAPC15/SMURF2/UBE2O/CUL4B/FBXW11/RBX1/UBE3A/UBE2J2/RPS27A/ANAPC13/UBE2Z	2.38185569752733
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/852	232/9376	1.47045491338838	PDGFRA/FN1/PDGFRB/FGF10/AKT3/PIP5K1B/MYL9/FGF2/TMSB4X/GSN/ITGB8/ACTB/WASL/ARHGEF1/CRK/FGF7/SRC/PIP5K1C/MAP2K2/NRAS/PPP1R12B/CRKL/ITGA5/CXCL12/RAC3/MAPK3/AKT2/BRK1/PPP1CA/BDKRB2/RRAS	2.29391651149869
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/852	53/9376	2.07635751616618	SLC8A1/PRKCA/PTH1R/ATP1B3/PLCB1/ESR1/PLCB3/RAB11A/ATP2B1/BDKRB2	2.48427892769497
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	17/852	110/9376	1.7007255655143	DCN/FBN1/GDF7/EMP3/ACVR2B/PPP2R1A/SKI/TGFBR2/PPP2CA/ZFYVE9/RGMA/SMAD7/SMURF2/RBX1/MAPK3/SMAD4/E2F5	2.33712463081769
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/852	46/9376	2.15309246785058	PSMB9/PSMC5/PSMC6/PSMD13/PSMD14/PSMC2/PSMD3/PSMD6/PSMA5	2.47848299942393
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	30/852	226/9376	1.46080019942665	EDNRA/AKT3/ADCY3/MYL9/ADCY1/CACNA1D/CACNA1C/GRIA1/GABBR1/ATP1B3/RYR2/FXYD1/ACOX1/GRIA3/CAMK4/FOS/MAP2K2/PDE4B/BAD/GLI3/ADCY5/RELA/PDE4D/RAC3/MAPK3/AKT2/ATP2B1/PPP1CA/PDE3B/RRAS	2.21686907954016
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/852	155/9376	1.56195668635469	ADCY3/ADCY1/CACNA1D/WNT4/CACNA1C/CACNA1G/CDK6/ITPR2/WNT5A/LEF1/PLCB1/WNT2/AXIN1/MAP2K2/ADCY5/PLCB3/RBBP5/CDKN1B/LDLR/CCNE2/MAPK3/PBX1	2.23030057372511
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	45/852	368/9376	1.34568279240661	TUBB6/GRIA1/COX7A1/ERBB4/GPX8/ACTB/NDUFS2/ULK2/TBK1/NUP153/UQCRC2/KIF5C/TARDBP/HDAC6/NDUFA8/ULK1/PSMC5/NDUFS4/PSMC6/NUP205/TUBA4A/NUP43/DNALI1/NUP62/APAF1/SDHD/BAD/DNAL4/PSMD13/CASP3/ANG/ATP5PB/SEC13/TNFRSF1A/PSMD14/CAT/RAE1/VCP/TRAF2/PSMC2/PSMD3/NDUFB1/PSMD6/NUP35/PSMA5	2.13880503184572
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/852	87/9376	1.77087043332794	AKT3/LEF1/TGFBR2/AXIN1/FOS/MAP2K2/NRAS/BAD/CASP3/RAC3/MAPK3/AKT2/BAK1/SMAD4	2.28370629275246
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/852	157/9376	1.5420591489489	AXL/LRP1/MEGF10/ATP8A2/ANO4/ADAM9/SLC16A1/VPS16/TGFBRAP1/CRK/MFGE8/RAB7B/MAP2K2/CRKL/CASP3/RAB5C/DNMT3A/XKR6/ODC1/MAPK3/NR1H3/PBX1	2.16540089866304
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/852	184/9376	1.49520310267401	SLIT3/GDF7/EPHA6/NRP1/MYL9/ROBO1/PRKCA/TRPC4/WNT4/UNC5C/SEMA6D/PLXNB2/WNT5A/LRIG2/FYN/SRC/EPHA5/NRAS/RGMA/CXCL12/PLXNC1/SMO/RAC3/MAPK3/RRAS	2.14472184746575
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/852	56/9376	1.96512407780013	CCND2/SPOP/ARRB1/CSNK1E/GPR161/GLI3/SMURF2/CSNK1G3/FBXW11/SMO	2.29009196437404
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	21/852	150/9376	1.54065727699531	FGF10/AKT3/CTNNA2/HGF/CTNNA3/WNT4/FGF2/WNT5A/LEF1/TGFBR2/FGF7/WNT2/AXIN1/MAP2K2/NRAS/CDKN1B/CCNE2/MAPK3/AKT2/BAK1/SMAD4	2.1103022997479
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/852	115/9376	1.62678097570933	MMP16/ADCY3/ADCY1/PRKCA/AKAP13/PTH1R/ARRB1/ITPR2/ARHGEF1/PLCB1/FOS/PDE4B/ADCY5/PLCB3/PDE4D/MAPK3/ARHGEF11	2.13805808341714
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/852	98/9376	1.68439206668583	AKT3/PIP5K1B/PLPP3/PRKCA/GSN/CRK/LYN/PRKCD/PIP5K1C/PLPP1/CRKL/MARCKS/INPPL1/MAPK3/AKT2	2.15315123602928
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/852	73/9376	1.80899093189273	BST2/MAP1B/MX1/MX2/VPS4A/NELFCD/NUP153/CHMP6/CCNT1/HGS/RAN/TNPO3	2.19370026751335
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/852	73/9376	1.80899093189273	AKT3/HGF/PRKCA/CDK6/KIF5C/EML4/MAP2K2/NRAS/BAD/MAPK3/AKT2/BAK1	2.19370026751335
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	11/852	65/9376	1.86233297219213	ADCY3/ADCY1/CACNA1D/CACNA1C/CACNA1G/ITPR2/PLCB1/ADCY5/PLCB3/LDLR/PBX1	2.20555159696538
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/852	205/9376	1.44939883201649	CCND2/CDK6/GSN/HLA-A/TRAF5/HDAC6/HDAC3/SNW1/YWHAG/UBR4/LYN/SRC/NRAS/BAD/RELA/CASP3/CDKN1B/VDAC3/REL/UBE3A/SP100/TRAF2/CCNE2/MAPK3/BAK1/DDX3X/GTF2B	2.05676293952601
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	38/852	308/9376	1.35772209011646	TGM2/TUBB6/GRIA1/COX7A1/GPX8/NDUFS2/ULK2/POLR2B/UQCRC2/KIF5C/PLCB1/NDUFA8/GRIA3/ULK1/TFAM/POLR2E/PSMC5/NDUFS4/PSMC6/TUBA4A/DNALI1/APAF1/SDHD/DNAL4/PSMD13/PLCB3/CASP3/POLR2J/ATP5PB/VDAC3/PSMD14/POLR2F/TRAF2/PSMC2/PSMD3/NDUFB1/PSMD6/PSMA5	2.01812971581901
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/852	90/9376	1.71184141888367	IGF1/AKT3/ADCY3/ADCY1/ULK1/CAMK4/SESN2/NRAS/ADCY5/RELA/TSC2/STK11/CAT/AKT2	2.14523011090129
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	25/852	187/9376	1.4712158871231	OAS2/TAB2/ITPR2/STAT1/BIRC2/TBK1/TRAF5/MAP3K7/TICAM1/PLCB1/MFN2/TYK2/PRKCD/IFI16/GBP1/CARD8/RELA/PLCB3/GSDMD/ATG12/VDAC3/TRAF2/MAPK3/CHUK/OAS1	2.05773913330442
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/852	169/9376	1.49768036225241	AKT3/ULK2/TBK1/ATG3/MAP3K7/RRAGC/VPS16/RAB7B/ULK1/PPP2CA/PRKCD/ATG10/MAP2K2/NRAS/BAD/TSC2/STK11/ATG12/MAPK3/AKT2/RPS27A/CALCOCO2/RRAS	2.06404185737344
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/852	99/9376	1.66737800540617	IGF1/AKT3/MMP2/ADCY3/ADCY1/ESR1/SRC/FOS/MAP2K2/NRAS/BAD/ADCY5/CDKN1B/MAPK3/AKT2	2.11042257430348
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	15/852	99/9376	1.66737800540617	IGF1/LAMA2/CACNA2D1/SLC8A1/CACNA1D/TPM2/CACNA1C/CACNB2/ITGB8/ACTB/RYR2/SGCB/TTN/SNTB2/ITGA5	2.11042257430348
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/852	76/9376	1.73758339510749	IGF1/PDGFRA/PDGFRB/AKT3/PRKCA/CDK6/CAMK4/MAP2K2/NRAS/MAPK3/AKT2/BAK1	2.04108066175126
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/852	60/9376	1.83411580594679	AKT3/PRKCA/SRC/MAP2K2/NRAS/BAD/RAC3/MAPK3/AKT2/SH2D2A	2.04913679245625
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/852	29/9376	2.27683341427878	FRMD6/RASSF2/CSNK1E/NF2/LATS1/LATS2	2.17711230360775
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/852	77/9376	1.71501737698921	AKT3/CDK6/STAT1/TGFBR2/BAD/RELA/RAC3/MAPK3/AKT2/CHUK/BAK1/SMAD4	1.99171663355149
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/852	212/9376	1.40154132341217	IGF1/PDGFRA/PDGFRB/MAGI2/FGF10/AKT3/ADCY3/ADCY1/HGF/PRKCA/FGF2/ACTB/PLCB1/CRK/FGF7/SRC/MAP2K2/NRAS/ADCY5/APBB1IP/CRKL/PLCB3/RAC3/SIPA1L1/MAPK3/AKT2/RRAS	1.86955975768724
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/852	86/9376	1.66350038213779	AKT3/PRKCA/ERBB4/CRK/SRC/MAP2K2/NRAS/BAD/CRKL/CDKN1B/MAP2K4/MAPK3/AKT2	1.95418763513523
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/852	70/9376	1.72930918846412	LAMA2/HLA-DRA/ACTB/HLA-A/SGCB/HLA-DRB5/HLA-DMA/FYN/SNTB2/CASP3/RAC3	1.93625653339335
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/852	23/9376	2.39232496427842	MME/ENPEP/ANPEP/LNPEP/PREP	2.11355121487526
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/852	71/9376	1.70495272102096	PDGFRA/PDGFRB/AKT3/NTRK3/SLC1A5/MAP2K2/NRAS/MAPK3/AKT2/SIRT3/SCO2	1.88501448535126
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/852	217/9376	1.36924774453171	FGF10/AKT3/ADCY3/ADCY1/PRKCA/PGR/CACNA1D/FGF2/CACNA1C/AR/ARRB1/KPNA4/CYP1B1/FGF7/ESR1/SRC/FOS/MAP2K2/NRAS/BAD/ADCY5/RELA/KPNA1/GSTA4/MAPK3/AKT2/KPNA3	1.73983235774679
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/852	109/9376	1.5144075461946	AKT3/TAB2/STAT1/TBK1/MAP3K7/TICAM1/TYK2/TOLLIP/FOS/MAP2K2/RELA/MAP2K4/MAPK3/AKT2/CHUK	1.7077909722249
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/852	119/9376	1.47962283504951	AKT3/IL15/TAB2/BIRC2/TRAF5/MAP3K7/FOS/RELA/CASP3/TNFRSF1A/MAP2K4/TRAF2/MAPK3/AKT2/CHUK/RHBDF2	1.66464609283261
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/852	110/9376	1.50064020486556	IGF1/AKT3/ADCY3/ADCY1/PGR/ANAPC4/CPEB2/ANAPC10/CPEB3/ANAPC15/ADCY5/MAPK3/AKT2/ANAPC13/PDE3B	1.66978145447019
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/852	49/9376	1.79668487113155	GALNT13/ST6GAL2/GALNT17/GXYLT2/RFNG/POFUT1/GALNT18/OGT	1.76765431113823
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/852	138/9376	1.43539497856705	AKT3/PTPN1/CRK/PHKG1/EXOC7/FBP1/MAP2K2/NRAS/BAD/CRKL/TSC2/PRKAR2B/INPPL1/MAPK3/AKT2/PPP1CA/PDE3B/PRKAR1A	1.62898728818215
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/852	75/9376	1.61402190923318	AKT3/REV3L/BIRC2/TOP2B/APAF1/BAD/CASP3/GSTA4/MAPK3/AKT2/BAK1	1.6878482286432
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/852	75/9376	1.61402190923318	IGF1/CCND2/CDK6/RPRM/SERPINE1/SFN/SESN2/APAF1/CASP3/TSC2/CCNE2	1.6878482286432
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/852	148/9376	1.41276487755361	IGF1/FGF10/AKT3/PGR/WNT4/FGF2/CDK6/WNT5A/LEF1/FGF7/ESR1/WNT2/AXIN1/FOS/MAP2K2/NRAS/MAPK3/AKT2/BAK1	1.60016038937271
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	30/852	253/9376	1.30490452597005	AKT3/MYL9/ACTB/TAB2/ITPR2/TBK1/TRAF5/WASL/MAP3K7/RRAGC/CAPN1/PLCB1/CRK/PRKCD/SRC/CRKL/RELA/PLCB3/ITGA5/ATG12/TNFRSF1A/FBXW11/RBX1/TRAF2/MAPK3/AKT2/CHUK/RPS27A/CALCOCO2/ARHGEF2	1.55431489636431
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/852	139/9376	1.42506839598744	AKT3/MMP2/ADCY3/ADCY1/PGR/GABBR1/ITPR2/PLCB1/ESR1/PRKCD/SRC/FOS/MAP2K2/NRAS/ADCY5/PLCB3/MAPK3/AKT2	1.59618953656544
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/852	149/9376	1.4032832340801	ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/GRIA1/NDUFS2/ITPR2/GABRA2/PLCB1/NDUFA8/GRIA3/NDUFS4/ADCY5/PLCB3/GNG2/MAPK3/DAGLA/NDUFB1	1.56876089925967
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/852	34/9376	1.94200497100249	RORB/RORA/CSNK1E/FBXW11/RBX1/BHLHE40	1.7396281902958
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	16/852	122/9376	1.44323866697452	AKT3/PPP2R1A/MAP3K7/FYN/PPP2CA/FOS/MAP2K2/NRAS/RELA/PPP2R5C/MAPK3/AKT2/PPP2R5D/CHUK/PPP2R2A/TEC1	1.55788904324301
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/852	68/9376	1.6183374758354	RUNX1T1/AKT3/LEF1/MAP2K2/NRAS/BAD/RELA/MAPK3/AKT2/CHUK	1.61783994046936
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/852	275/9376	1.28054630815194	CACNA1D/CACNA1C/TUBB6/COX7A1/NDUFS2/PRNP/ITPR2/UQCRC2/KIF5C/RYR2/NDUFA8/FYN/PRKCD/PSMC5/NDUFS4/PSMC6/TUBA4A/APAF1/SDHD/BAD/STIP1/PSMD13/CASP3/ATP5PB/VDAC3/PSMD14/MAPK3/PSMC2/PSMD3/NDUFB1/PSMD6/PSMA5	1.49282899861382
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/852	170/9376	1.35940347970174	AKT3/HGF/PRKCA/WNT4/CDK6/ACTB/WNT5A/LEF1/TGFBR2/WNT2/AXIN1/SMARCC2/ACTL6A/MAP2K2/NRAS/BAD/GSTA4/MAPK3/AKT2/BAK1/SMAD4	1.49504742067776
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	18/852	142/9376	1.39496131719897	AKT3/MMP2/PLAT/ACTB/ACVR2B/MAP3K7/SRC/FOS/DUSP1/RELA/TNFRSF1A/MAP2K4/MAP2K5/GSTA4/RAC3/AKT2/CHUK/ARHGEF2	1.4992964570904
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/852	69/9376	1.59488330951895	AKT3/PRKCA/LYN/FYN/MAP2K2/NRAS/MAP2K4/RAC3/MAPK3/AKT2	1.56796075247351
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/852	69/9376	1.59488330951895	PRKCA/CACNA1D/CACNA1C/GRIA1/GRIA3/CAMK4/FOS/ADCY5/MAOB/PPP1CA	1.56796075247351
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/852	78/9376	1.55194414349344	INPP4B/PIP5K1B/PLCB1/PI4K2B/PIP5K1C/ITPKC/PLCB3/INPPL1/MTM1/INPP4A/IMPA2	1.54750255603745
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	31/852	268/9376	1.27293111905262	SNCAIP/TUBB6/COX7A1/NDUFS2/SLC39A14/ITPR2/UQCRC2/KIF5C/NDUFA8/MFN2/PSMC5/NDUFS4/PSMC6/TUBA4A/DUSP1/APAF1/SDHD/ADCY5/PSMD13/CASP3/MAOB/ATP5PB/VDAC3/PSMD14/UBE2J2/RPS27A/PSMC2/PSMD3/NDUFB1/PSMD6/PSMA5	1.43315332952505
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/852	89/9376	1.48377907896819	PLCL1/ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/GABBR1/NSF/GABRA2/SRC/ADCY5/GNG2	1.44973318088925
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/852	193/9376	1.31144031720548	AKT3/ADCY3/ADCY1/ARRB1/STAT1/CXCL13/PLCB1/CRK/LYN/PRKCD/SRC/NRAS/BAD/ADCY5/CRKL/RELA/PLCB3/CXCL12/GNG2/RAC3/MAPK3/AKT2/CHUK	1.38211732345282
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/852	13/9376	2.53954496208017	DCLRE1C/MRE11/XRCC4	1.75606366294509
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/852	99/9376	1.44506093801868	IGF1/ADCY3/ADCY1/PRKCA/PRKCH/ITPR2/PLCB1/PRKCD/SRC/ADCY5/PLCB3/PPP1CA/BDKRB2	1.40739827043545
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/852	37/9376	1.78454510848877	GALK2/GNPNAT1/PGM3/GMPPB/GFPT2/UGP2	1.51165368951435
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/852	37/9376	1.78454510848877	LEF1/MAP2K2/NRAS/MAPK3/BAK1/TFG	1.51165368951435
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/852	21/9376	2.09613234965348	ENPP1/COASY/DPYD/PANK2	1.58977060136246
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/852	205/9376	1.28835451734799	COL3A1/COL1A1/AKT3/MMP2/PRKCA/COX7A1/NDUFS2/COL1A2/UQCRC2/RYR2/PLCB1/TGFBR2/NDUFA8/PRKCD/NDUFS4/SDHD/RELA/PLCB3/ATP5PB/VDAC3/GFPT2/AKT2/PPP1CA/NDUFB1	1.31971167362646
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/852	91/9376	1.4511685497601	AKT3/LYN/FOS/MAP2K2/NRAS/RELA/INPPL1/PIK3AP1/RAC3/MAPK3/AKT2/CHUK	1.36726367334964
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/852	101/9376	1.41644586993911	ADCY3/ADCY1/PRKCA/WNT4/WNT5A/LEF1/PLCB1/WNT2/MAP2K2/NRAS/ADCY5/PLCB3/MAPK3	1.3302890067744
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/852	38/9376	1.73758339510749	GALK2/GNPNAT1/PGM3/GMPPB/GFPT2/UGP2	1.44032238250855
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	15/852	120/9376	1.37558685446009	AKT3/NTRK3/CRK/MAGED1/PRKCD/CAMK4/MAP2K2/NRAS/BAD/CRKL/RELA/MAP2K5/MAPK3/AKT2/IRAK3	1.309100680653
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	26/852	227/9376	1.26044962875639	AKT3/HGF/COX7A1/NDUFS2/UQCRC2/PTPN1/NDUFA8/CYP1B1/PRKCD/SRC/NDUFS4/FOS/MAP2K2/NRAS/SDHD/BAD/RELA/ATP5PB/VDAC3/MAP2K4/CAT/GSTA4/MAPK3/AKT2/CHUK/NDUFB1	1.25583786261777
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/852	30/9376	1.83411580594679	ABCG2/RELA/MTHFR/CHUK/GART	1.44663112506344
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/852	93/9376	1.41996062395881	MAF/HLA-DRA/STAT1/MAML1/IL2RB/HLA-DRB5/HLA-DMA/TYK2/FOS/RELA/MAPK3/CHUK	1.28673639908816
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/852	122/9376	1.35303625028862	IGF1/AKT3/PPP2R1A/MAP3K7/ULK1/STRADA/PPP2CA/FBP1/SCD5/TSC2/STK11/PPP2R5C/AKT2/PPP2R5D/PPP2R2A	1.24084685559224
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/852	200/9376	1.26553990610329	OCLN/TUBB6/ACTB/TAB2/WIPF1/WASL/MAP3K7/ARHGEF1/FYN/SRC/FOS/TUBA4A/RELA/CASP3/TNFRSF1A/TRAF2/MAPK3/CHUK/BAK1/BRK1/ARHGEF11/SEC24B/ARHGEF2	1.20005681555984
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/852	142/9376	1.31746346624347	AKT3/TAB2/ITPR2/STAT1/MAP3K7/TGFBR2/FYN/TYK2/CAMK4/FOS/RELA/TNFRSF1A/TRAF2/MAPK3/AKT2/CHUK/TEC1	1.20511004361142
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/852	76/9376	1.44798616258957	ADCY3/ADCY1/PRKCA/ACTB/ITPR2/ATP1B3/PLCB1/ADCY5/PLCB3/KCNJ2	1.23969153760638
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/852	86/9376	1.40757724642428	ADCY3/ADCY1/PRKCA/CACNA1D/ABCC8/CACNA1C/ATP1B3/RYR2/PLCB1/ADCY5/PLCB3	1.20042495342436
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/852	32/9376	1.71948356807512	ULK2/ATG3/PPP2CA/ATG10/ATG12	1.28888203127245
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/852	32/9376	1.71948356807512	BIRC2/APAF1/CASP3/TNFRSF1A/BAK1	1.28888203127245
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/852	174/9376	1.2649074523771	TUSC3/MAN1B1/CAPN1/MAGT1/MAN1A1/UBXN6/DNAJA2/SEC13/SEC23B/RBX1/DDOST/DNAJC3/VCP/TRAF2/UBE2J2/BAK1/PLAA/SEC24B/SAR1A/BCAP31	1.11509379914589
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/852	87/9376	1.39139819761481	CACNA2D1/SLC8A1/CACNA1D/TPM2/CACNA1C/COX7A1/CACNB2/UQCRC2/ATP1B3/RYR2/SLC9A6	1.15951849781824
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/852	116/9376	1.32815282499595	ADCY3/ADCY1/PRKCA/CACNA1D/CACNA1C/GRIA1/GRM7/ITPR2/PLCB1/GRIA3/ADCY5/PLCB3/GNG2/MAPK3	1.12430298495335
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/852	155/9376	1.27796456156293	C1R/MRC2/THBS2/TUBB6/HLA-DRA/ACTB/TAP1/HLA-A/TAP2/HLA-DRB5/HLA-DMA/RAB7B/STX12/TUBA4A/HGS/TCIRG1/RAB5C/ITGA5	1.10318915351023
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/852	78/9376	1.41085831226676	FN1/CTNNA2/CTNNA3/ACTB/ARHGAP10/WASL/CRK/SRC/CRKL/ITGA5	1.1519359266643
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/852	69/9376	1.43539497856705	EDNRA/CACNA1D/CACNA1C/ITPR2/PLCB1/ADCY5/PLCB3/KCNJ2/PDE3B	1.14759016985909
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/852	117/9376	1.31680109144898	ACTB/ACTR6/RBBP7/EP400/BCL7B/SMARCC2/ACTL6A/SMARCA5/MBD3/BCL7C/UCHL5/BAZ1A/SS18L1/RBBP4	1.09013748420164
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/852	216/9376	1.22274387063119	AKT3/PRKCA/TAB2/TBK1/MAP3K7/ARHGEF1/TICAM1/PLCB1/LYN/SRC/FOS/NRAS/APAF1/BAD/RELA/PLCB3/CASP3/TNFRSF1A/MAP2K4/LDLR/TRAF2/MAPK3/AKT2/CHUK	1.04705288062244
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/852	33/9376	1.66737800540617	SNAP23/GOSR1/STX8/STX5/STX2	1.21414176957834
NA	NA	hsa04517	IgSF CAM signaling	32/852	299/9376	1.17775998241399	NLGN1/SLIT3/MAGI2/AKT3/NTRK3/NRP1/CLMP/MYL9/ROBO1/PMP22/PRKCA/UNC5C/JAM3/TUBB6/ACTB/CNTNAP1/LRFN5/ANK3/WASL/KCNQ3/LYN/FYN/CDH2/SRC/MAP2K2/KIRREL1/TUBA4A/MBP/NECTIN2/ITGA5/MAPK3/AKT2	0.987602407915776
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	13/852	109/9376	1.31248654003532	RORA/HLA-DRA/STAT1/IL2RB/TGFBR2/HLA-DRB5/HLA-DMA/TYK2/FOS/RELA/MAPK3/CHUK/SMAD4	1.0374297499365
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/852	90/9376	1.34501825769431	AKT3/STAT1/EML4/TICAM1/FOS/MAP2K2/NRAS/RELA/MAPK3/AKT2/CHUK	1.03975904686363
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/852	62/9376	1.41996062395881	IGF1/AKT3/ADCY3/ADCY1/NRAS/ADCY5/CAT/AKT2	1.04886601872028
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/852	62/9376	1.41996062395881	DTX1/CIR1/ATXN1/MAML1/SNW1/TLE1/RFNG/CTBP1	1.04886601872028
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/852	91/9376	1.33023783728009	ADCY3/ADCY1/PRKCA/GABBR1/ARRB1/GABRA2/PDE4B/ADCY5/PDE4D/GNG2/PDE3B	1.00078385055586
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/852	63/9376	1.39742156643565	POLR2B/CUL4A/POLR2E/PCNA/POLR2J/CUL4B/RBX1/POLR2F	1.00060027775391
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/852	63/9376	1.39742156643565	WNT4/WNT5A/LEF1/WNT2/AXIN1/GLI3/SMO/BAK1	1.00060027775391
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/852	102/9376	1.29466998066832	ADCY3/ADCY1/PRKCA/ITPR2/ATP1B3/RYR2/PLCB1/ADCY5/PLCB3/RAB11A/ATP2B1/SCTR	0.945989137955567
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/852	45/9376	1.46729264475743	ABCC8/ABCC9/TAP1/TAP2/ABCA8/ABCG2	0.993378651595802
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/852	45/9376	1.46729264475743	HLA-DRA/HLA-A/HLA-DRB5/HLA-DMA/KLRC1/GZMB	0.993378651595802
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/852	36/9376	1.52842983828899	SSBP1/MCM5/PCNA/MCM4/POLA1	1.00426623161012
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/852	133/9376	1.24113099650535	IGF1/AKT3/CCND2/CSNK1E/TGFBR2/MAP2K2/NRAS/STK11/ATG12/CDKN1B/CAT/MAPK3/AKT2/CHUK/SMAD4	0.885433807154635
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/852	94/9376	1.28778343821796	TAB2/TBK1/TRAF5/TRAF3IP2/MAP3K7/FOS/RELA/CASP3/TRAF2/MAPK3/CHUK	0.886528407986029
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/852	75/9376	1.32056338028169	ADCY3/ADCY1/PRKCA/GPX8/ITPR2/ATP1B3/PLCB1/ADCY5/PLCB3	0.881177569464963
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/852	56/9376	1.37558685446009	CLK4/HBS1L/APAF1/RELA/CASP3/VCP/SAR1A	0.891210215461754
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/852	105/9376	1.25767940979209	AKT3/ITPR2/STAT1/PRKCD/SRC/NRAS/RELA/MAPK3/AKT2/CHUK/LSP1/RRAS	0.839449918211911
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/852	115/9376	1.24400898142478	PRKCA/CACNA1D/CACNA1C/ITPR2/PLCB1/NRAS/DUSP1/ADCY5/PLCB3/CASP3/MAOB/GNG2/MAPK3	0.832356748816794
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/852	47/9376	1.40485465987414	CACNA1D/ABCC8/CACNA1C/CACNA1G/PRKCD/MAPK3	0.879658776052477
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/852	38/9376	1.44798616258957	IGF1/PRKCA/ATP1B3/SFN/MAPK3	0.874808870850251
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/852	48/9376	1.37558685446009	AKT3/CACNA1D/ATP1B3/PLCB1/PLCB3/AKT2	0.824746438095059
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/852	20/9376	1.65070422535211	EBP/LBR/MSMO1	0.920952504262685
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/852	78/9376	1.26977248104009	HLA-DRA/TAB2/STAT1/MAP3K7/HLA-DRB5/HLA-DMA/FOS/RELA/MAPK3	0.75636929729115
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/852	88/9376	1.25053350405463	C1R/CFD/C1S/MASP1/TFPI/F10/PLAT/SERPINE1/PROCR/BDKRB2	0.746499911239768
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/852	39/9376	1.41085831226676	MTHFD2/BHMT2/MTHFR/MAT2B/GART	0.812838783086442
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/852	39/9376	1.41085831226676	HLA-DRA/HLA-A/HLA-DRB5/HLA-DMA/GZMB	0.812838783086442
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/852	59/9376	1.30564176016551	PRKG1/AKT3/ADCY3/ADCY1/ADCY5/AKT2/PDE3B	0.744533708775761
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	19/852	181/9376	1.15518896065157	AKT3/MRC2/HLA-DRA/STAT1/HLA-DRB5/HLA-DMA/CEBPG/SRC/HSPA9/TCIRG1/APAF1/BAD/RELA/CASP3/RAB5C/TNFRSF1A/MAPK3/AKT2/LSP1	0.666511980522867
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/852	254/9376	1.1264648256996	PDGFRA/EDNRA/PDGFRB/FGF10/NTRK3/SLC8A1/ADCY3/ADCY1/HGF/PRKCA/CACNA1D/FGF2/CACNA1C/CACNA1G/ERBB4/ITPR2/RYR2/PLCB1/FGF7/PHKG1/CAMK4/ITPKC/PLCB3/VDAC3/ATP2B1/BDKRB2	0.645989247488789
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/852	110/9376	1.20051216389245	IGF1/AKT3/PRKCA/SERPINE1/MAP2K2/RELA/CDKN1B/EGLN2/RBX1/EGLN1/MAPK3/AKT2	0.668766689948929
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/852	12/9376	1.83411580594679	COQ5/GGCX	0.914050070409879
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/852	50/9376	1.32056338028169	LRP1/HGF/THBS2/GYPC/KLRB1/HBB	0.718513480576414
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/852	41/9376	1.34203595557082	MMP2/SRC/MAP2K2/NRAS/MAPK3	0.693889386511489
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/852	71/9376	1.23996561528797	JAM3/LYN/SRC/TCIRG1/RELA/CASP3/MAP2K4/CHUK	0.641658152831792
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/852	82/9376	1.20783236001374	B2M/HLA-DRA/TAP1/HLA-A/TAP2/TAPBP/HLA-DRB5/HLA-DMA/KLRC1	0.597588837224972
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/852	144/9376	1.14632237871674	IGF1/AKT3/TBX3/WNT4/FGF2/PCGF3/ACVR2B/WNT5A/WNT2/AXIN1/MAP2K2/NRAS/MAPK3/AKT2/SMAD4	0.559406896197131
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/852	72/9376	1.22274387063119	ISG15/TBK1/MAP3K7/RELA/ATG12/TRAF2/CHUK/DDX3X	0.599819906183037
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/852	32/9376	1.37558685446009	ACSS3/ACOX1/SUCLG1/PCCB	0.672825856455437
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/852	52/9376	1.26977248104009	IGF1/ADCY3/ADCY1/CYP1B1/ADCY5/LDLR	0.616711292117283
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/852	52/9376	1.26977248104009	APOE/LRP1/APOC1/ANGPTL4/VDAC3/LDLR	0.616711292117283
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/852	93/9376	1.18330051996567	PRKG1/ADCY3/ADCY1/PRKCA/ITPR2/ATP1B3/PLCB1/ADCY5/PLCB3/ATP2B1	0.561622774983665
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/852	83/9376	1.19328016290514	TBK1/POLR2E/IFI16/DDX41/RELA/CASP3/GSDMD/POLR2F/CHUK	0.559154823506779
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	11/852	104/9376	1.16395810762008	DGKB/PLPP3/GNPAT/MBOAT2/CDS1/MBOAT7/PCYT1A/PLPP1/LYPLA1/GDPD5/PEMT	0.53155299603873
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/852	63/9376	1.22274387063119	PRDM6/HADH/SETD1B/KMT2B/SMYD3/DOT1L/SETDB2	0.560808968724255
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/852	23/9376	1.43539497856705	GGPS1/HMGCS1/NUS1	0.660930177588173
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/852	157/9376	1.12149756287192	AKT3/COX7A1/NDUFS2/UQCRC2/NDUFA8/MLX/NDUFS4/FOS/SDHD/RELA/CASP3/TNFRSF1A/TRAF2/AKT2/NR1H3/NDUFB1	0.485354656107901
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/852	105/9376	1.15287279230941	TAB2/BIRC2/TRAF5/MAP3K7/TICAM1/LYN/RELA/TNFRSF1A/CXCL12/TRAF2/CHUK	0.498018266591449
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/852	44/9376	1.25053350405463	HLA-DRA/HLA-A/HLA-DRB5/HLA-DMA/GZMB	0.52660927132402
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/852	34/9376	1.29466998066832	POLR2B/POLR2E/POLR2J/POLR2F	0.544175690133573
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/852	128/9376	1.11766431924883	ADCY3/ADCY1/XDH/ENPP1/CANT1/ADA2/ITPA/PDE4B/ADCY5/PDE4D/NUDT5/GART/PDE3B	0.423749867948197
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/852	55/9376	1.20051216389245	PLPP3/ARSA/KDSR/GBA2/CERS5/PLPP1	0.471492218633788
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/852	66/9376	1.16716460378432	RORA/MAF/HLA-DRA/STAT1/HLA-DRB5/HLA-DMA/RELA	0.430849075742037
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/852	15/9376	1.46729264475743	ST6GALNAC3/SLC33A1	0.572607678122535
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/852	109/9376	1.11056553387604	AKT3/PTPN1/MLX/PRKCD/RELA/TNFRSF1A/GFPT2/AKT2/OGT/NR1H3/PPP1CA	0.367068527648106
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/852	238/9376	1.06347891269184	IGF1/PDGFRA/PDGFRB/FGF10/AKT3/HGF/PRKCA/FGF2/TBK1/FGF7/MAP2K2/NRAS/EXOC2/BAD/RELA/RAB5C/GNG2/REL/RAC3/MAPK3/AKT2/CHUK/RRAS	0.313600030317642
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/852	78/9376	1.12868664981341	MTREX/CNOT6L/LSM2/HSPA9/DCPS/PATL1/LSM8/PABPC5	0.360802667918001
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/852	78/9376	1.12868664981341	C1R/C1S/TICAM1/FOS/RELA/CASP3/ITGA5/MAPK3	0.360802667918001
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/852	36/9376	1.22274387063119	GALNT13/ST6GALNAC3/GALNT17/GALNT18	0.423318539879095
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/852	144/9376	1.0699008868023	AKT3/TAB2/TBK1/LEF1/MAP3K7/TICAM1/ACOX1/RELA/SCD5/CASP3/TNFRSF1A/MAP2K4/AKT2/CHUK	0.26723894506387
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/852	37/9376	1.18969673899251	PRKCA/PLCB1/PLCB3/HBB	0.365505784542124
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/852	27/9376	1.22274387063119	FADS2/ACOX1/SCD5	0.366428107345899
Genetic Information Processing	Transcription	hsa03040	Spliceosome	23/852	243/9376	1.04159663053768	MAGOH/SLU7/CASC3/EFTUD2/SNW1/U2AF2/LSM2/PRPF31/SF3B4/ACIN1/CHERP/LSM8/SRSF10/TXNL4A/SRSF6/NCBP2/RBMX2/CRNKL1/YJU2/SNIP1/RBMX/SNRPF/RBM25	0.207700850941083
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/852	70/9376	1.10046948356808	AKT3/RELA/STK11/TNFRSF1A/TRAF2/AKT2/CHUK	0.266738301179257
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/852	38/9376	1.15838893007166	ENPP1/SIRT2/NADK/SIRT3	0.309295359191953
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/852	17/9376	1.29466998066832	CYP7B1/CYP39A1	0.384440688816126
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/852	17/9376	1.29466998066832	PCDH20/PCDH7	0.384440688816126
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/852	170/9376	1.03573598453466	MYL9/CACNA1D/JAM3/OCLN/ACTB/PPP2R1A/AMOTL1/NF2/PPP2CA/SRC/TJAP1/PCNA/TUBA4A/STK11/PPP2R2A/ARHGEF2	0.148654630579147
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/852	50/9376	1.10046948356808	IL15/HLA-DRA/HLA-DRB5/HLA-DMA/CXCL12	0.225193152963317
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/852	83/9376	1.0606934781379	XDH/GNPAT/PXMP2/ACOX1/SLC25A17/FAR2/PEX26/CAT	0.17558476020567
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/852	18/9376	1.22274387063119	GBA2/MAN2C1	0.299043391407223
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/852	107/9376	1.02847615286736	AKT3/ITPR2/PLCB1/PPP4R3B/PHKG1/PPP4R3A/FBP1/PLCB3/AKT2/PDE3B	0.0936570509063175
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/852	30/9376	1.10046948356808	SUCLG1/ACLY/SDHD	0.174247126133345
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/852	19/9376	1.15838893007166	HPSE2/GALNS	0.218482685798023
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/852	42/9376	1.04806617482674	HADH/CYP1B1/MAOB/CAT	0.0986992889035108
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/852	42/9376	1.04806617482674	SLC39A14/PRNP/VDAC3/SLC3A2	0.0986992889035108
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/852	76/9376	1.0135903138127	FABP5/FADS2/ACOX1/ANGPTL4/HMGCS1/SCD5/NR1H3	0.0376078513890518
NA	NA	hsa04981	Folate transport and metabolism	3/852	31/9376	1.0649704679691	BHMT2/ABCG2/MTHFR	0.114548894980259
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/852	54/9376	1.018953225526	HLA-DRA/HLA-A/HLA-DRB5/HLA-DMA/GZMB	0.0441579777200813
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/852	20/9376	1.10046948356808	GMPPB/UGP2	0.142196129806793
Human Diseases	Immune disease	hsa05310	Asthma	3/852	32/9376	1.03169014084507	HLA-DRA/HLA-DRB5/HLA-DMA	0.0567696816384274
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/852	168/9376	0.982562038900067	PDGFRA/PDGFRB/AKT3/CCND2/IL15/PRLR/STAT1/FHL1/IL20RB/PIAS3/IL2RB/GHR/TYK2/SOCS7/AKT2	-0.0721026796227496
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/852	44/9376	1.0004268032437	TAF15/TAF5L/TAF7/GTF2B	0.000897119712647465
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/852	44/9376	1.0004268032437	SMUG1/PCNA/APTX/POLG	0.000897119712647465
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/852	44/9376	1.0004268032437	ADCY3/NSF/RAB5C/RAB11A	0.000897119712647465
NA	NA	hsa04519	Cadherin signaling	36/852	404/9376	0.980616371496304	LHFPL3/PDGFRA/VIM/PDGFRB/CDH11/PCDH18/CTNNA2/LHFPL6/PRICKLE1/CTNNA3/WNT4/CDH13/ACTB/PCDH20/WNT5A/AMOTL1/NF2/LATS1/LEF1/GABRA2/YWHAG/LATS2/WNT2/CDH2/AXIN1/GJA1/MAP2K2/NRAS/RELA/RAC3/MAPK3/CHUK/BRK1/PPP1CA/RRAS/PCDH7	-0.125911339135754
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/852	57/9376	0.965324108393048	FADS2/HADH/ACOX1/SCD5/PPT1	-0.0830164434781956
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/852	22/9376	1.0004268032437	ASPA/MAOB	0.000633613007128787
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/852	116/9376	0.948680589282824	CTNNA2/MMP2/MYL9/PRKCA/CTNNA3/JAM3/OCLN/ACTB/CXCL12/THY1	-0.175828340518111
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/852	23/9376	0.95692998571137	RXYLT1/POMK	-0.06538034105537
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/852	23/9376	0.95692998571137	SSBP1/PCNA	-0.06538034105537
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/852	59/9376	0.932601257261081	UCK2/ENPP1/CANT1/DPYD/TK2	-0.164181216176274
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/852	59/9376	0.932601257261081	GPX8/ANPEP/GSTA4/ODC1/SMS	-0.164181216176274
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	28/852	323/9376	0.95396735417666	ZEB1/PDGFRA/VIM/TIMP3/PDGFRB/ZEB2/MMP16/HOXD10/PRKCA/ZFPM2/CCND2/TNXB/CDK6/SLC7A1/RECK/CRK/CYP1B1/MAP2K2/NRAS/CRKL/CASP3/ITGA5/MARCKS/CDKN1B/DNMT3A/CCNE2/MAPK3/BAK1	-0.266167272116687
NA	NA	hsa03272	Virion - Hepatitis viruses	4/852	48/9376	0.917057902973396	OCLN/VPS4A/IST1/LDLR	-0.182131505079325
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/852	24/9376	0.917057902973396	XYLT1/B3GALT6	-0.128621064112741
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/852	235/9376	0.936569773249426	PRKG1/ADCY3/ADCY1/COX7A1/ACTB/NDUFS2/ZNF516/UQCRC2/NDUFA8/SMARCC2/ACTL6A/NDUFS4/NRAS/SDHD/ADCY5/NDUFAF5/TSC2/KDM1A/ATP5PB/NDUFB1	-0.311327192768702
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/852	61/9376	0.902024166859078	SLC8A1/ATP1B3/HEPH/TRPM6/ATP2B1	-0.242703572016389
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/852	85/9376	0.906268986467826	XDH/UCK2/ENPP1/CANT1/ADA2/ITPA/TK2	-0.274438641619534
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	21/852	250/9376	0.924394366197183	ARSA/GALNS/GGA1/CLN8/AP5M1/RRAGC/VPS16/AP3D1/OSTM1/TMEM175/AP3M1/CTSC/AP5B1/CTBS/LITAF/TCIRG1/LAMTOR5/AP1G1/BORCS5/SNAPIN/PPT1	-0.383060742044573
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/852	38/9376	0.868791697553744	DCLRE1C/TAP1/TAP2	-0.256218152466345
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/852	51/9376	0.863113320445549	ADCY3/PRKCA/ACTB/TCIRG1	-0.309888579944738
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/852	26/9376	0.846514987360058	FADS2/ACOX1	-0.247759638063718
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/852	195/9376	0.902949319850728	AKT3/PRKCA/ACTB/MAP3K7/PLCB1/HDAC6/HDAC3/SRC/MAP2K2/RELA/PLCB3/GSDMD/VDAC3/CLCN3/MAPK3/AKT2	-0.432966814531622
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/852	160/9376	0.894131455399061	NLGN1/JAM3/OCLN/ITGB8/HLA-DRA/CNTNAP1/HLA-A/HLA-DRB5/HLA-DMA/CDH2/NECTIN2/NRXN2/IGSF11	-0.427011347405296
NA	NA	hsa04081	Hormone signaling	18/852	219/9376	0.904495465946363	IGF1/PRKG1/RAMP1/ADCY3/ADCY1/ADRA2C/PTH1R/PRLR/PLCB1/HEPH/ESR1/GHR/SRC/ADCY5/PLCB3/STK11/GNG2/SMAD4	-0.452119413427888
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/852	27/9376	0.815162580420796	HADH/HMGCS1	-0.304069537945894
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/852	90/9376	0.855920709441836	ADCY3/ADCY1/ATP1B3/ABCG2/ADCY5/LDLR/SCTR	-0.434202371853244
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/852	41/9376	0.805221573342494	MRE11/SSBP1/TOPBP1	-0.395147588368277
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/852	41/9376	0.805221573342494	GRIA1/GABRA2/GRIA3	-0.395147588368277
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/852	54/9376	0.815162580420796	BHMT2/DNMT3A/MAT2B/SMS	-0.430641562536207
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/852	28/9376	0.786049631120054	HADH/PPT1	-0.358439958589129
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/852	28/9376	0.786049631120054	B3GALT5/B3GALT1	-0.358439958589129
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/852	82/9376	0.805221573342494	XDH/UCK2/ITPA/DPYD/TK2/GSTA4	-0.560054331746379
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/852	95/9376	0.810872251050161	IL15/HLA-DRA/HLA-DRB5/HLA-DMA/FOS/TCIRG1/CXCL12	-0.585737979617959
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/852	133/9376	0.827420664336899	PRKCA/HLA-A/FYN/MAP2K2/NRAS/CASP3/KLRC1/GZMB/RAC3/MAPK3	-0.633711884523351
Cellular Processes	Cell motility	hsa04814	Motor proteins	15/852	194/9376	0.850878466676347	STARD9/MYL9/TPM2/KIF26B/MYO19/TUBB6/ACTB/KIFC2/BICDL1/KIFAP3/MYO15B/KIF5C/TUBA4A/DNALI1/DNAL4	-0.663523480980837
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/852	16/9376	0.687793427230047	MAOB	-0.395137114326052
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/852	16/9376	0.687793427230047	B3GALT5	-0.395137114326052
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/852	31/9376	0.709980311979403	PGLS/FBP1	-0.511331314422366
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/852	31/9376	0.709980311979403	ACOX1/DPYD	-0.511331314422366
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/852	31/9376	0.709980311979403	PCCB/CAT	-0.511331314422366
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/852	31/9376	0.709980311979403	SGTA/OXA1L	-0.511331314422366
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/852	46/9376	0.717697489283527	HEPH/UROS/UROD	-0.60678739391101
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/852	17/9376	0.647334990334162	FMO5	-0.460103804703086
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/852	17/9376	0.647334990334162	CA5B	-0.460103804703086
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/852	99/9376	0.778109735856215	C1R/CFD/C1S/MASP1/HLA-DRA/HLA-DRB5/HLA-DMA	-0.701674641168619
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/852	100/9376	0.770328638497653	MME/HLA-DRA/ANPEP/HLA-DRB5/GP1BB/HLA-DMA/ITGA5	-0.72997870327627
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/852	18/9376	0.611371935315597	MMADHC	-0.521750179387309
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/852	48/9376	0.687793427230047	HADH/PCCB/HMGCS1	-0.685570476666517
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/852	49/9376	0.673756826674332	ADCY5/RELA/MAOB	-0.723856034807656
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/852	154/9376	0.786049631120054	MTHFD2/COASY/UROS/COQ5/NADK/PANK2/MAT2B/GMPPB/GGCX/UGP2/UROD	-0.846339393959775
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	8/852	116/9376	0.758944471426259	PGLS/ACOX1/SUCLG1/ADPGK/PCCB/FBP1/SDHD/CAT	-0.825894003253839
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/852	35/9376	0.628839704896043	FBP1/GMPPB	-0.695476664446713
NA	NA	hsa04382	Cornified envelope formation	16/852	217/9376	0.811406070833604	COL4A2/COL4A1/S100A4/S100A6/COL4A6/OCLN/PPP2R1A/CAPN1/KDSR/PPP2CA/GBA2/COL7A1/PPP2R5C/S100A1/PPP2R5D/PPP2R2A	-0.888622409473181
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/852	50/9376	0.660281690140845	MAOB/ODC1/SMS	-0.761447502262879
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/852	168/9376	0.786049631120054	VPS4A/STAT1/BIRC2/TRAF5/CHMP6/CAPN1/TICAM1/TYK2/AIFM1/TNFRSF1A/VDAC3/TRAF2	-0.884644415371428
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/852	36/9376	0.611371935315597	ENPP1/UGP2	-0.738576843582964
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/852	65/9376	0.677211989888046	DGKB/PLPP3/MBOAT2/PLPP1	-0.825580876693047
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/852	51/9376	0.647334990334162	PLPP3/PLA2G7/PLPP1	-0.798374680409072
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/852	37/9376	0.594848369496257	ASPA/GFPT2	-0.780642120430101
NA	NA	hsa04082	Neuroactive ligand signaling	14/852	199/9376	0.774199636681058	ADCY3/ADCY1/P2RY14/PRKCA/ADRA2C/GRIA1/GRM7/GABBR1/GABRA2/PLCB1/GRIA3/ADCY5/PLCB3/GNG2	-1.0178517409408
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/852	68/9376	0.647334990334162	ALDH1A3/ALDH1A1/ALDH1A2/CYP27C1	-0.922725146931386
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/852	54/9376	0.611371935315597	REV3L/WDR48/FAN1	-0.905441102792495
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/852	23/9376	0.478464992855685	ATP1B3	-0.791690859698913
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/852	138/9376	0.717697489283527	COX7A1/NDUFS2/UQCRC2/NDUFA8/NDUFS4/TCIRG1/SDHD/ATP5PB/NDUFB1	-1.05620694775242
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/852	86/9376	0.639807839283765	CACNA1C/GABBR1/GABRA2/PLCB1/PLCB3	-1.06086309170827
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/852	43/9376	0.511846271427012	HADH/ACOX1	-1.01429415026456
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/852	43/9376	0.511846271427012	PLPP3/PLPP1	-1.01429415026456
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/852	28/9376	0.393024815560027	TCIRG1	-1.01689079160866
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/852	79/9376	0.557199738515481	NSF/SYT1/TCIRG1/STX2	-1.2494926733467
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/852	30/9376	0.366823161189358	PIGB	-1.09813687279675
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/852	32/9376	0.343896713615023	UGP2	-1.17534266799559
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/852	100/9376	0.550234741784038	IL20RB/CXCL13/IL2RB/TNFRSF1A/CXCL12	-1.42951675743799
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/852	73/9376	0.452247732973181	MAOB/GSTA4/FMO5	-1.48531243965428
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/852	36/9376	0.305685967657799	UGP2	-1.31952453531399
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/852	37/9376	0.297424184748128	MAOB	-1.35371607291621
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/852	41/9376	0.268407191114165	MAOB	-1.48418456324804
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/852	66/9376	0.333475601081235	CYP7B1/CYP1B1	-1.71789610200123
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/852	67/9376	0.328498353303903	ADPGK/FBP1	-1.74388034672752
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/852	47/9376	0.234142443312356	ACYP1	-1.66403746261888
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/852	70/9376	0.314419852448021	CYP1B1/GSTA4	-1.82015948908836
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/852	191/9376	0.518545829953543	HDAC6/HDAC3/CAMK4/NRAS/ADCY5/MAOB/GNG2/MAPK3/PPP1CA	-2.12527811938316
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/852	79/9376	0.27859986925774	CYP1B1/GSTA4	-2.03564508948539
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/852	143/9376	0.384779539709117	C1R/C1S/HLA-DRA/HLA-DRB5/HLA-DMA	-2.34374892735516
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/852	63/9376	0.174677695804456	PTGDS	-2.07793888545371
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/852	183/9376	0.420944611200903	UTP6/NOP56/BMS1/RAN/POP5/POP4/TBL3	-2.50092540053172
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/852	75/9376	0.146729264475743	MAT2B	-2.34550506724798
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/852	298/9376	0.480070580080033	GDF7/IL15/PRLR/ACVR2B/IL20RB/CXCL13/IL2RB/TGFBR2/GHR/TNFRSF1A/CXCL12/GDF11/IL16	-2.883640725021
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/852	370/9376	0.505621114071818	CALCRL/EDNRA/P2RY14/ADRA2C/GRIA1/S1PR3/GRM7/PTH1R/PRLR/GABBR1/NPW/GABRA2/GRIA3/GHR/GZMA/BDKRB2/SCTR	-3.06745726021783
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/852	449/9376	0.122546713092213	PRKG1/SLC8A1/ADCY3/SLC24A4/ARRB1	-6.02390512670084