ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 44/1693 168/18639 0.261904761904762 2.88342755885579 7.18431941666495e-11 8.65710489708127e-08 GO:0048407 platelet-derived growth factor binding 8/1693 11/18639 0.727272727272727 8.00687322128551 5.85795705084508e-07 0.00028509997570391 GO:0030020 extracellular matrix structural constituent conferring tensile strength 16/1693 44/18639 0.363636363636364 4.00343661064275 7.09792470632141e-07 0.00028509997570391 GO:0005518 collagen binding 21/1693 72/18639 0.291666666666667 3.21108978145304 9.67278160069313e-07 0.000291392545720881 GO:0046332 SMAD binding 22/1693 79/18639 0.278481012658228 3.06592297397325 1.28261294878287e-06 0.000309109720656672 GO:0005178 integrin binding 33/1693 161/18639 0.204968944099379 2.25659548084366 6.85746915774961e-06 0.00137720838918138 GO:0003735 structural constituent of ribosome 34/1693 175/18639 0.194285714285714 2.13897898911484 1.67029438954307e-05 0.00287529248485628 GO:0140297 DNA-binding transcription factor binding 69/1693 488/18639 0.141393442622951 1.55666413292923 0.000143609758534496 0.0191731295643779 GO:0043022 ribosome binding 23/1693 112/18639 0.205357142857143 2.26086933592102 0.000156900345865673 0.0191731295643779 GO:0097493 structural molecule activity conferring elasticity 6/1693 11/18639 0.545454545454545 6.00515491596413 0.000172093893676392 0.0191731295643779 GO:0032182 ubiquitin-like protein binding 24/1693 120/18639 0.2 2.20189013585351 0.000175024419259881 0.0191731295643779 GO:0016004 phospholipase activator activity 8/1693 20/18639 0.4 4.40378027170703 0.000211633894366558 0.0212515702259752 GO:0004222 metalloendopeptidase activity 22/1693 110/18639 0.2 2.20189013585351 0.000320218973996785 0.029681835666625 GO:0140142 nucleocytoplasmic carrier activity 10/1693 32/18639 0.3125 3.44045333727112 0.00037111416934375 0.0319423267185156 GO:0097110 scaffold protein binding 16/1693 70/18639 0.228571428571429 2.51644586954687 0.000436853072988046 0.0350938635300397 GO:0008237 metallopeptidase activity 31/1693 184/18639 0.168478260869565 1.85485310357225 0.000562734309859807 0.0407872938928002 GO:0043130 ubiquitin binding 20/1693 100/18639 0.2 2.20189013585351 0.000587464453451615 0.0407872938928002 GO:0043021 ribonucleoprotein complex binding 30/1693 177/18639 0.169491525423729 1.86600858970637 0.000618446754128737 0.0407872938928002 GO:0005158 insulin receptor binding 8/1693 23/18639 0.347826086956522 3.82937414931046 0.000643119156815936 0.0407872938928002 GO:0001098 basal transcription machinery binding 14/1693 60/18639 0.233333333333333 2.56887182516243 0.00078556483204125 0.0450764582195098 GO:0001099 basal RNA polymerase II transcription machinery binding 14/1693 60/18639 0.233333333333333 2.56887182516243 0.00078556483204125 0.0450764582195098 GO:0060229 lipase activator activity 8/1693 24/18639 0.333333333333333 3.66981689308919 0.000888475098799169 0.0486642042751363 GO:0001222 transcription corepressor binding 12/1693 49/18639 0.244897959183673 2.69619200308594 0.00116354352715688 0.0609595630532189 GO:0060589 nucleoside-triphosphatase regulator activity 65/1693 490/18639 0.13265306122449 1.46043733500488 0.00123128212797524 0.0618206235087569 GO:0043394 proteoglycan binding 10/1693 37/18639 0.27027027027027 2.97552721061286 0.00131695334694968 0.0634771513229745 GO:0008201 heparin binding 28/1693 172/18639 0.162790697674419 1.79223615709007 0.00173073479093645 0.0802129008876316 GO:0030695 GTPase regulator activity 64/1693 489/18639 0.130879345603272 1.44090970035404 0.00186424729961232 0.0832006665197352 GO:0005521 lamin binding 6/1693 16/18639 0.375 4.12854400472534 0.00200229259279675 0.0861700919400028 GO:0031491 nucleosome binding 15/1693 74/18639 0.202702702702703 2.23164540795964 0.00237477697221406 0.0945524051011264 GO:0140296 general transcription initiation factor binding 12/1693 53/18639 0.226415094339623 2.49270581417379 0.00239676205753152 0.0945524051011264 GO:0050840 extracellular matrix binding 14/1693 67/18639 0.208955223880597 2.30048223148875 0.00243246851297504 0.0945524051011264 GO:0019838 growth factor binding 23/1693 136/18639 0.169117647058824 1.8618923942879 0.00260066144122509 0.0979311573961322 GO:1990459 transferrin receptor binding 5/1693 12/18639 0.416666666666667 4.58727111636149 0.00282290715060883 0.101316163307584 GO:0004549 tRNA-specific ribonuclease activity 6/1693 17/18639 0.352941176470588 3.88568847503561 0.0028587133215418 0.101316163307584 GO:0008013 beta-catenin binding 19/1693 106/18639 0.179245283018868 1.97339210288758 0.00303424770804952 0.104464813948562 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 47/1693 349/18639 0.134670487106017 1.48264808574664 0.00408047104728431 0.136582433666044 GO:0016504 peptidase activator activity 12/1693 57/18639 0.210526315789474 2.31777909037212 0.00453199412630482 0.147596024924251 GO:0001223 transcription coactivator binding 10/1693 44/18639 0.227272727272727 2.50214788165172 0.00523211853616761 0.165913232528473 GO:0044325 transmembrane transporter binding 22/1693 136/18639 0.161764705882353 1.78094055105799 0.00550645914811599 0.16860474728588 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 7/1693 25/18639 0.28 3.08264619019492 0.00559683808417858 0.16860474728588 GO:0004175 endopeptidase activity 52/1693 405/18639 0.128395061728395 1.41355909956028 0.00686935115483577 0.189401468950787 GO:0005539 glycosaminoglycan binding 34/1693 242/18639 0.140495867768595 1.54678232683925 0.00704002574843506 0.189401468950787 GO:0061608 nuclear import signal receptor activity 6/1693 20/18639 0.3 3.30283520378027 0.0070660400562819 0.189401468950787 GO:0004529 DNA exonuclease activity 7/1693 26/18639 0.269230769230769 2.96408287518742 0.00706882664871091 0.189401468950787 GO:0005516 calmodulin binding 30/1693 207/18639 0.144927536231884 1.59557256221269 0.00708101391565529 0.189401468950787 GO:0001221 transcription coregulator binding 19/1693 115/18639 0.165217391304348 1.81895272092247 0.00754462282957494 0.189401468950787 GO:0035401 histone H3Y41 kinase activity 19/1693 115/18639 0.165217391304348 1.81895272092247 0.00754462282957494 0.189401468950787 GO:0140801 histone H2AXY142 kinase activity 19/1693 115/18639 0.165217391304348 1.81895272092247 0.00754462282957494 0.189401468950787 GO:0004713 protein tyrosine kinase activity 22/1693 140/18639 0.157142857142857 1.73005653531348 0.00776303377155955 0.190907259076107 GO:0030331 nuclear estrogen receptor binding 9/1693 40/18639 0.225 2.4771264028352 0.00846380311549255 0.203977655083371 GO:0003712 transcription coregulator activity 61/1693 495/18639 0.123232323232323 1.35672018471782 0.00880049397175179 0.207933239920802 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 4/1693 10/18639 0.4 4.40378027170703 0.00910516433184942 0.210994673459203 GO:0031625 ubiquitin protein ligase binding 40/1693 302/18639 0.132450331125828 1.45820538798246 0.00997439949210334 0.226776441282727 GO:0042826 histone deacetylase binding 20/1693 127/18639 0.15748031496063 1.73377176051458 0.0105441034167728 0.235289715133542 GO:0044389 ubiquitin-like protein ligase binding 42/1693 322/18639 0.130434782608696 1.43601530599142 0.0108784154570839 0.238336193196112 GO:0005154 epidermal growth factor receptor binding 8/1693 35/18639 0.228571428571429 2.51644586954687 0.011590735319375 0.249407786782981 GO:0034056 estrogen response element binding 4/1693 11/18639 0.363636363636364 4.00343661064275 0.0132915004622106 0.276142380292479 GO:0140031 phosphorylation-dependent protein binding 4/1693 11/18639 0.363636363636364 4.00343661064275 0.0132915004622106 0.276142380292479 GO:0000993 RNA polymerase II complex binding 8/1693 36/18639 0.222222222222222 2.44654459539279 0.0137454375593064 0.280733089134986 GO:0070403 NAD+ binding 5/1693 17/18639 0.294117647058824 3.23807372919634 0.0150308719758692 0.296921323457743 GO:1990226 histone methyltransferase binding 5/1693 17/18639 0.294117647058824 3.23807372919634 0.0150308719758692 0.296921323457743 GO:0031267 small GTPase binding 37/1693 283/18639 0.130742049469965 1.43939814534594 0.0155123167919078 0.298887620052399 GO:0017124 SH3 domain binding 18/1693 115/18639 0.156521739130435 1.72321836718971 0.0156264896790881 0.298887620052399 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/1693 30/18639 0.233333333333333 2.56887182516243 0.0158994292715686 0.299356441753752 GO:1901681 sulfur compound binding 36/1693 275/18639 0.130909090909091 1.44123717983139 0.0164889419034195 0.305679615286469 GO:0042277 peptide binding 33/1693 249/18639 0.132530120481928 1.45908382496317 0.017809932386707 0.310049798988944 GO:0140104 molecular carrier activity 33/1693 249/18639 0.132530120481928 1.45908382496317 0.017809932386707 0.310049798988944 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/1693 24/18639 0.25 2.75236266981689 0.0179404612653023 0.310049798988944 GO:0035035 histone acetyltransferase binding 6/1693 24/18639 0.25 2.75236266981689 0.0179404612653023 0.310049798988944 GO:0042605 peptide antigen binding 9/1693 45/18639 0.2 2.20189013585351 0.0182276845400963 0.310049798988944 GO:0005049 nuclear export signal receptor activity 4/1693 12/18639 0.333333333333333 3.66981689308919 0.0185257971180116 0.310049798988944 GO:0015368 calcium:monoatomic cation antiporter activity 4/1693 12/18639 0.333333333333333 3.66981689308919 0.0185257971180116 0.310049798988944 GO:0008409 5'-3' exonuclease activity 5/1693 18/18639 0.277777777777778 3.05818074424099 0.01928810565837 0.318385853675834 GO:0042578 phosphoric ester hydrolase activity 45/1693 363/18639 0.12396694214876 1.36480793544639 0.0200050966645173 0.325758668658695 GO:0000030 mannosyltransferase activity 6/1693 25/18639 0.24 2.64226816302422 0.0218384475330256 0.350367008789202 GO:0003925 G protein activity 10/1693 54/18639 0.185185185185185 2.03878716282733 0.022097836238987 0.350367008789202 GO:0070717 poly-purine tract binding 7/1693 32/18639 0.21875 2.40831733608978 0.0224307719230187 0.35102701515893 GO:0017154 semaphorin receptor activity 4/1693 13/18639 0.307692307692308 3.38752328592848 0.0248720340683851 0.379377228511443 GO:0140666 annealing activity 4/1693 13/18639 0.307692307692308 3.38752328592848 0.0248720340683851 0.379377228511443 GO:0003713 transcription coactivator activity 33/1693 256/18639 0.12890625 1.41918700162434 0.025593308964013 0.381380087071994 GO:0004435 phosphatidylinositol phospholipase C activity 6/1693 26/18639 0.230769230769231 2.54064246444636 0.02626933379832 0.381380087071994 GO:0070006 metalloaminopeptidase activity 6/1693 26/18639 0.230769230769231 2.54064246444636 0.02626933379832 0.381380087071994 GO:0070412 R-SMAD binding 6/1693 26/18639 0.230769230769231 2.54064246444636 0.02626933379832 0.381380087071994 GO:0140693 molecular condensate scaffold activity 9/1693 48/18639 0.1875 2.06427200236267 0.0270342885894599 0.38781330655118 GO:0042169 SH2 domain binding 8/1693 41/18639 0.195121951219512 2.14818549839367 0.0290346913395442 0.394047473856727 GO:0051020 GTPase binding 39/1693 315/18639 0.123809523809524 1.36307484600456 0.0291976268905723 0.394047473856727 GO:0045296 cadherin binding 41/1693 334/18639 0.122754491017964 1.35145951452087 0.0292570449095706 0.394047473856727 GO:0019787 ubiquitin-like protein transferase activity 56/1693 479/18639 0.116910229645094 1.28711740717951 0.0299339527866223 0.394047473856727 GO:0015095 magnesium ion transmembrane transporter activity 5/1693 20/18639 0.25 2.75236266981689 0.0299986658070084 0.394047473856727 GO:0043024 ribosomal small subunit binding 5/1693 20/18639 0.25 2.75236266981689 0.0299986658070084 0.394047473856727 GO:0003714 transcription corepressor activity 27/1693 204/18639 0.132352941176471 1.45713317813835 0.0302514753074622 0.394047473856727 GO:0004065 arylsulfatase activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0005161 platelet-derived growth factor receptor binding 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0008191 metalloendopeptidase inhibitor activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0008195 phosphatidate phosphatase activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0008331 high voltage-gated calcium channel activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0008474 palmitoyl-(protein) hydrolase activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0034236 protein kinase A catalytic subunit binding 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0098599 palmitoyl hydrolase activity 4/1693 14/18639 0.285714285714286 3.14555733693359 0.0323740248230838 0.394047473856727 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 13/1693 82/18639 0.158536585365854 1.74540071744486 0.033059695341884 0.395020833727511 GO:0043175 RNA polymerase core enzyme binding 8/1693 42/18639 0.19047619047619 2.09703822462239 0.0331096300468702 0.395020833727511 GO:0043015 gamma-tubulin binding 7/1693 35/18639 0.2 2.20189013585351 0.0353665837604678 0.417811112072194 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/1693 21/18639 0.238095238095238 2.62129778077799 0.0365154008388568 0.422616079507038 GO:0016791 phosphatase activity 34/1693 273/18639 0.124542124542125 1.37114037763772 0.0367808013984156 0.422616079507038 GO:0046875 ephrin receptor binding 6/1693 28/18639 0.214285714285714 2.35916800270019 0.036825467508912 0.422616079507038 GO:0016755 aminoacyltransferase activity 57/1693 496/18639 0.11491935483871 1.26519896919002 0.0382168455409754 0.429055799525781 GO:0005021 vascular endothelial growth factor receptor activity 9/1693 51/18639 0.176470588235294 1.94284423751781 0.0384760384294096 0.429055799525781 GO:0035173 histone kinase activity 43/1693 360/18639 0.119444444444444 1.31501772002363 0.0386132030499106 0.429055799525781 GO:0002020 protease binding 19/1693 136/18639 0.139705882352941 1.53808502136826 0.0388108565546142 0.429055799525781 GO:0017022 myosin binding 12/1693 76/18639 0.157894736842105 1.73833431777909 0.0406508230247528 0.437811241415079 GO:0015556 C4-dicarboxylate transmembrane transporter activity 4/1693 15/18639 0.266666666666667 2.93585351447135 0.0410561579086339 0.437811241415079 GO:0141050 histone H3K deacetylase activity 4/1693 15/18639 0.266666666666667 2.93585351447135 0.0410561579086339 0.437811241415079 GO:0141051 histone H4K deacetylase activity 4/1693 15/18639 0.266666666666667 2.93585351447135 0.0410561579086339 0.437811241415079 GO:0004629 phospholipase C activity 6/1693 29/18639 0.206896551724138 2.27781738191743 0.0429889027121179 0.454400243579842 GO:0004407 histone deacetylase activity 5/1693 22/18639 0.227272727272727 2.50214788165172 0.0438356248026143 0.455361447303019 GO:0033558 protein lysine deacetylase activity 5/1693 22/18639 0.227272727272727 2.50214788165172 0.0438356248026143 0.455361447303019 GO:0005085 guanyl-nucleotide exchange factor activity 29/1693 230/18639 0.126086956521739 1.38814812912504 0.044263888233783 0.455880216424859 GO:0042805 actinin binding 7/1693 37/18639 0.189189189189189 2.082869047429 0.0462805681453666 0.47261088656921 GO:0070851 growth factor receptor binding 19/1693 139/18639 0.136690647482014 1.50488894177039 0.0468715808321134 0.474623990778963 GO:0051018 protein kinase A binding 9/1693 53/18639 0.169811320754717 1.86952936063034 0.0477077429963969 0.475318910729879 GO:0019199 transmembrane receptor protein kinase activity 12/1693 78/18639 0.153846153846154 1.69376164296424 0.048248091163902 0.475318910729879 GO:0140996 histone H3 kinase activity 42/1693 357/18639 0.117647058823529 1.29522949167854 0.0496445970655083 0.475318910729879 GO:0008187 poly-pyrimidine tract binding 6/1693 30/18639 0.2 2.20189013585351 0.0497612710722552 0.475318910729879 GO:0003688 DNA replication origin binding 4/1693 16/18639 0.25 2.75236266981689 0.0509246021072347 0.475318910729879 GO:0005159 insulin-like growth factor receptor binding 4/1693 16/18639 0.25 2.75236266981689 0.0509246021072347 0.475318910729879 GO:0008296 3'-5'-DNA exonuclease activity 4/1693 16/18639 0.25 2.75236266981689 0.0509246021072347 0.475318910729879 GO:0070411 I-SMAD binding 4/1693 16/18639 0.25 2.75236266981689 0.0509246021072347 0.475318910729879 GO:0005525 GTP binding 44/1693 378/18639 0.116402116402116 1.28152335949146 0.0524548441448188 0.475318910729879 GO:0005501 retinoid binding 7/1693 38/18639 0.184210526315789 2.02805670407561 0.0524618483560892 0.475318910729879 GO:0019840 isoprenoid binding 7/1693 38/18639 0.184210526315789 2.02805670407561 0.0524618483560892 0.475318910729879 GO:0042887 amide transmembrane transporter activity 7/1693 38/18639 0.184210526315789 2.02805670407561 0.0524618483560892 0.475318910729879 GO:0051287 NAD binding 9/1693 54/18639 0.166666666666667 1.8349084465446 0.0528297243478788 0.475318910729879 GO:0030291 protein serine/threonine kinase inhibitor activity 8/1693 46/18639 0.173913043478261 1.91468707465523 0.0532355969991913 0.475318910729879 GO:0140299 molecular sensor activity 11/1693 71/18639 0.154929577464789 1.70568954185836 0.0546362838853015 0.475318910729879 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/1693 10/18639 0.3 3.30283520378027 0.0552514695226771 0.475318910729879 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 3/1693 10/18639 0.3 3.30283520378027 0.0552514695226771 0.475318910729879 GO:0045322 unmethylated CpG binding 3/1693 10/18639 0.3 3.30283520378027 0.0552514695226771 0.475318910729879 GO:0140999 histone H3K4 trimethyltransferase activity 3/1693 10/18639 0.3 3.30283520378027 0.0552514695226771 0.475318910729879 GO:0000149 SNARE binding 15/1693 106/18639 0.141509433962264 1.55794113385862 0.0558979601825149 0.475318910729879 GO:0061134 peptidase regulator activity 28/1693 226/18639 0.123893805309735 1.3640027390243 0.0568986849227166 0.475318910729879 GO:0140313 molecular sequestering activity 9/1693 55/18639 0.163636363636364 1.80154647478924 0.0582976645618843 0.475318910729879 GO:0061659 ubiquitin-like protein ligase activity 43/1693 372/18639 0.115591397849462 1.27259779357125 0.0598501628213889 0.475318910729879 GO:0033192 calmodulin-dependent protein phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0140791 histone H2AXS140 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:1990439 MAP kinase serine/threonine phosphatase activity 12/1693 81/18639 0.148148148148148 1.63102973026186 0.061376883765827 0.475318910729879 GO:0004659 prenyltransferase activity 4/1693 17/18639 0.235294117647059 2.59045898335708 0.0619688267630396 0.475318910729879 GO:0008484 sulfuric ester hydrolase activity 4/1693 17/18639 0.235294117647059 2.59045898335708 0.0619688267630396 0.475318910729879 GO:0031489 myosin V binding 4/1693 17/18639 0.235294117647059 2.59045898335708 0.0619688267630396 0.475318910729879 GO:0032183 SUMO binding 4/1693 17/18639 0.235294117647059 2.59045898335708 0.0619688267630396 0.475318910729879 GO:0032977 membrane insertase activity 4/1693 17/18639 0.235294117647059 2.59045898335708 0.0619688267630396 0.475318910729879 GO:0141003 histone H2AX kinase activity 41/1693 354/18639 0.115819209039548 1.27510586963269 0.063238649234754 0.475318910729879 GO:0003779 actin binding 50/1693 443/18639 0.112866817155756 1.24260165680221 0.0638747236806638 0.475318910729879 GO:0030515 snoRNA binding 6/1693 32/18639 0.1875 2.06427200236267 0.0651638203345935 0.475318910729879 GO:0033549 MAP kinase phosphatase activity 12/1693 82/18639 0.146341463414634 1.61113912379525 0.0662312589242172 0.475318910729879 GO:0016779 nucleotidyltransferase activity 18/1693 136/18639 0.132352941176471 1.45713317813835 0.0671477893388336 0.475318910729879 GO:0019843 rRNA binding 10/1693 65/18639 0.153846153846154 1.69376164296424 0.0675159660386438 0.475318910729879 GO:0008139 nuclear localization sequence binding 5/1693 25/18639 0.2 2.20189013585351 0.0706989433518585 0.475318910729879 GO:0017025 TBP-class protein binding 5/1693 25/18639 0.2 2.20189013585351 0.0706989433518585 0.475318910729879 GO:0019706 protein-cysteine S-palmitoyltransferase activity 5/1693 25/18639 0.2 2.20189013585351 0.0706989433518585 0.475318910729879 GO:0019707 protein-cysteine S-acyltransferase activity 5/1693 25/18639 0.2 2.20189013585351 0.0706989433518585 0.475318910729879 GO:0004016 adenylate cyclase activity 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0005536 D-glucose binding 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0019215 intermediate filament binding 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0034511 U3 snoRNA binding 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0035252 UDP-xylosyltransferase activity 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0042285 xylosyltransferase activity 3/1693 11/18639 0.272727272727273 3.00257745798207 0.070986457920352 0.475318910729879 GO:0016922 nuclear receptor binding 18/1693 137/18639 0.131386861313869 1.44649716953881 0.0710460308177631 0.475318910729879 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 12/1693 83/18639 0.144578313253012 1.59172780905073 0.0713298547877314 0.475318910729879 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/1693 128/18639 0.1328125 1.46219266834022 0.0717598157718214 0.475318910729879 GO:0005004 GPI-linked ephrin receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0005008 hepatocyte growth factor receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0005009 insulin receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0005011 macrophage colony-stimulating factor receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0005020 stem cell factor receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0008288 boss receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0036332 placental growth factor receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0038062 protein tyrosine kinase collagen receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0060175 brain-derived neurotrophic factor receptor activity 8/1693 49/18639 0.163265306122449 1.79746133539062 0.072579817074106 0.475318910729879 GO:0004721 phosphoprotein phosphatase activity 22/1693 175/18639 0.125714285714286 1.38404522825078 0.0739696507731878 0.480466660221576 GO:0031690 adrenergic receptor binding 4/1693 18/18639 0.222222222222222 2.44654459539279 0.0741633185072308 0.480466660221576 GO:0019003 GDP binding 11/1693 75/18639 0.146666666666667 1.61471943295924 0.0754443877252494 0.486026113096576 GO:0004842 ubiquitin-protein transferase activity 50/1693 449/18639 0.111358574610245 1.22599673488503 0.076610594460737 0.486026113096576 GO:0004527 exonuclease activity 12/1693 84/18639 0.142857142857143 1.5727786684668 0.076674951934607 0.486026113096576 GO:0017018 myosin phosphatase activity 12/1693 84/18639 0.142857142857143 1.5727786684668 0.076674951934607 0.486026113096576 GO:0051219 phosphoprotein binding 13/1693 93/18639 0.139784946236559 1.53895547129547 0.0772915730402988 0.486026113096576 GO:0019001 guanyl nucleotide binding 45/1693 400/18639 0.1125 1.2385632014176 0.0784855259170836 0.486026113096576 GO:0032561 guanyl ribonucleotide binding 45/1693 400/18639 0.1125 1.2385632014176 0.0784855259170836 0.486026113096576 GO:0003924 GTPase activity 38/1693 331/18639 0.114803625377644 1.26392485139628 0.0790057724861897 0.486026113096576 GO:0005006 epidermal growth factor receptor activity 8/1693 50/18639 0.16 1.76151210868281 0.0798615521934622 0.486026113096576 GO:0005007 fibroblast growth factor receptor activity 8/1693 50/18639 0.16 1.76151210868281 0.0798615521934622 0.486026113096576 GO:0005017 platelet-derived growth factor receptor activity 8/1693 50/18639 0.16 1.76151210868281 0.0798615521934622 0.486026113096576 GO:0005019 platelet-derived growth factor beta-receptor activity 8/1693 50/18639 0.16 1.76151210868281 0.0798615521934622 0.486026113096576 GO:0097602 cullin family protein binding 5/1693 26/18639 0.192307692307692 2.1172020537053 0.0812774218169866 0.491292076265581 GO:0042056 chemoattractant activity 7/1693 42/18639 0.166666666666667 1.8349084465446 0.0821597107716374 0.491292076265581 GO:0004722 protein serine/threonine phosphatase activity 14/1693 103/18639 0.135922330097087 1.49643018941501 0.0824984396502624 0.491292076265581 GO:0030332 cyclin binding 6/1693 34/18639 0.176470588235294 1.94284423751781 0.0830535788910438 0.491292076265581 GO:0004879 nuclear receptor activity 9/1693 59/18639 0.152542372881356 1.67940773073573 0.0837093744848536 0.491292076265581 GO:0070063 RNA polymerase binding 9/1693 59/18639 0.152542372881356 1.67940773073573 0.0837093744848536 0.491292076265581 GO:0008301 DNA binding, bending 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0016918 retinal binding 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0022821 solute:potassium antiporter activity 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0042577 lipid phosphatase activity 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0043395 heparan sulfate proteoglycan binding 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0140036 ubiquitin-modified protein reader activity 4/1693 19/18639 0.210526315789474 2.31777909037212 0.0874694009440052 0.491292076265581 GO:0005010 insulin-like growth factor receptor activity 8/1693 51/18639 0.156862745098039 1.72697265557138 0.0875611826611931 0.491292076265581 GO:0005030 neurotrophin receptor activity 8/1693 51/18639 0.156862745098039 1.72697265557138 0.0875611826611931 0.491292076265581 GO:0004526 ribonuclease P activity 3/1693 12/18639 0.25 2.75236266981689 0.0884733448544656 0.491292076265581 GO:0005095 GTPase inhibitor activity 3/1693 12/18639 0.25 2.75236266981689 0.0884733448544656 0.491292076265581 GO:0008179 adenylate cyclase binding 3/1693 12/18639 0.25 2.75236266981689 0.0884733448544656 0.491292076265581 GO:0008603 cAMP-dependent protein kinase regulator activity 3/1693 12/18639 0.25 2.75236266981689 0.0884733448544656 0.491292076265581 GO:0031543 peptidyl-proline dioxygenase activity 3/1693 12/18639 0.25 2.75236266981689 0.0884733448544656 0.491292076265581 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/1693 60/18639 0.15 1.65141760189014 0.0909565407965713 0.500468637716294 GO:0098531 ligand-modulated transcription factor activity 9/1693 60/18639 0.15 1.65141760189014 0.0909565407965713 0.500468637716294 GO:0005104 fibroblast growth factor receptor binding 5/1693 27/18639 0.185185185185185 2.03878716282733 0.0926454770095443 0.505148415368782 GO:0008266 poly(U) RNA binding 5/1693 27/18639 0.185185185185185 2.03878716282733 0.0926454770095443 0.505148415368782 GO:0008081 phosphoric diester hydrolase activity 12/1693 87/18639 0.137931034482759 1.51854492127829 0.0942035032404546 0.511329826147512 GO:0015026 coreceptor activity 9/1693 61/18639 0.147540983606557 1.62434518218702 0.0985607139223379 0.532581436217118 GO:0043014 alpha-tubulin binding 7/1693 44/18639 0.159090909090909 1.7515035171562 0.0999979793559936 0.537935558589162 GO:0042288 MHC class I protein binding 4/1693 20/18639 0.2 2.20189013585351 0.101837084728254 0.542980916360826 GO:0052745 inositol phosphate phosphatase activity 4/1693 20/18639 0.2 2.20189013585351 0.101837084728254 0.542980916360826 GO:0005484 SNAP receptor activity 6/1693 36/18639 0.166666666666667 1.8349084465446 0.103386728270901 0.545100912239055 GO:0005003 ephrin receptor activity 8/1693 53/18639 0.150943396226415 1.66180387611586 0.104204565191438 0.545100912239055 GO:0005005 transmembrane-ephrin receptor activity 8/1693 53/18639 0.150943396226415 1.66180387611586 0.104204565191438 0.545100912239055 GO:0038064 collagen receptor activity 8/1693 53/18639 0.150943396226415 1.66180387611586 0.104204565191438 0.545100912239055 GO:0051393 alpha-actinin binding 5/1693 28/18639 0.178571428571429 1.9659733355835 0.104780261683595 0.545100912239055 GO:0005096 GTPase activator activity 31/1693 271/18639 0.114391143911439 1.25938365703799 0.107508788351774 0.545100912239055 GO:0035673 oligopeptide transmembrane transporter activity 3/1693 13/18639 0.230769230769231 2.54064246444636 0.10755373809029 0.545100912239055 GO:0045159 myosin II binding 3/1693 13/18639 0.230769230769231 2.54064246444636 0.10755373809029 0.545100912239055 GO:0071837 HMG box domain binding 3/1693 13/18639 0.230769230769231 2.54064246444636 0.10755373809029 0.545100912239055 GO:0097157 pre-mRNA intronic binding 3/1693 13/18639 0.230769230769231 2.54064246444636 0.10755373809029 0.545100912239055 GO:0140333 glycerophospholipid flippase activity 3/1693 13/18639 0.230769230769231 2.54064246444636 0.10755373809029 0.545100912239055 GO:0048306 calcium-dependent protein binding 11/1693 80/18639 0.1375 1.51379946839929 0.107663084740992 0.545100912239055 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/1693 45/18639 0.155555555555556 1.71258121677496 0.109648334298259 0.552829467905449 GO:0017069 snRNA binding 8/1693 54/18639 0.148148148148148 1.63102973026186 0.113139320120752 0.563359011345069 GO:0050661 NADP binding 8/1693 54/18639 0.148148148148148 1.63102973026186 0.113139320120752 0.563359011345069 GO:0140463 chromatin-protein adaptor activity 8/1693 54/18639 0.148148148148148 1.63102973026186 0.113139320120752 0.563359011345069 GO:0023023 MHC protein complex binding 6/1693 37/18639 0.162162162162162 1.78531632636771 0.114439533456488 0.567488221461187 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/1693 21/18639 0.19047619047619 2.09703822462239 0.11720689270223 0.569367152893693 GO:0035613 RNA stem-loop binding 4/1693 21/18639 0.19047619047619 2.09703822462239 0.11720689270223 0.569367152893693 GO:0061891 calcium ion sensor activity 4/1693 21/18639 0.19047619047619 2.09703822462239 0.11720689270223 0.569367152893693 GO:0072542 protein phosphatase activator activity 4/1693 21/18639 0.19047619047619 2.09703822462239 0.11720689270223 0.569367152893693 GO:0016417 S-acyltransferase activity 5/1693 29/18639 0.172413793103448 1.89818115159786 0.117653461469319 0.569367152893693 GO:0043236 laminin binding 5/1693 29/18639 0.172413793103448 1.89818115159786 0.117653461469319 0.569367152893693 GO:0035091 phosphatidylinositol binding 32/1693 284/18639 0.112676056338028 1.2405014849879 0.119421057310228 0.575609496235301 GO:0016530 metallochaperone activity 3/1693 14/18639 0.214285714285714 2.35916800270019 0.128057296254073 0.605133497984934 GO:0030983 mismatched DNA binding 3/1693 14/18639 0.214285714285714 2.35916800270019 0.128057296254073 0.605133497984934 GO:0046030 inositol trisphosphate phosphatase activity 3/1693 14/18639 0.214285714285714 2.35916800270019 0.128057296254073 0.605133497984934 GO:0070742 C2H2 zinc finger domain binding 3/1693 14/18639 0.214285714285714 2.35916800270019 0.128057296254073 0.605133497984934 GO:1990825 sequence-specific mRNA binding 3/1693 14/18639 0.214285714285714 2.35916800270019 0.128057296254073 0.605133497984934 GO:0001540 amyloid-beta binding 11/1693 83/18639 0.132530120481928 1.45908382496317 0.130297525808792 0.613314525779665 GO:0001965 G-protein alpha-subunit binding 5/1693 30/18639 0.166666666666667 1.8349084465446 0.131231899548732 0.613419385360995 GO:0016757 glycosyltransferase activity 30/1693 267/18639 0.112359550561798 1.23701693025478 0.13133792649223 0.613419385360995 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/1693 22/18639 0.181818181818182 2.00171830532138 0.133511618902145 0.616404217536723 GO:0140035 ubiquitin-like protein reader activity 4/1693 22/18639 0.181818181818182 2.00171830532138 0.133511618902145 0.616404217536723 GO:0140784 metal ion sensor activity 4/1693 22/18639 0.181818181818182 2.00171830532138 0.133511618902145 0.616404217536723 GO:0004860 protein kinase inhibitor activity 11/1693 84/18639 0.130952380952381 1.4417137794279 0.138377639680245 0.636431510743109 GO:0003725 double-stranded RNA binding 10/1693 75/18639 0.133333333333333 1.46792675723568 0.140392375166176 0.643242631464801 GO:0008235 metalloexopeptidase activity 9/1693 66/18639 0.136363636363636 1.50128872899103 0.14180607181488 0.647258774761099 GO:0017147 Wnt-protein binding 5/1693 31/18639 0.161290322580645 1.77571785149477 0.145478154508599 0.648702631072087 GO:0051536 iron-sulfur cluster binding 10/1693 76/18639 0.131578947368421 1.44861193148258 0.149340836639265 0.648702631072087 GO:0004559 alpha-mannosidase activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0005523 tropomyosin binding 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0031386 protein tag activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0042809 nuclear vitamin D receptor binding 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0051371 muscle alpha-actinin binding 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0061578 K63-linked deubiquitinase activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0120283 protein serine/threonine kinase binding 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0141047 molecular tag activity 3/1693 15/18639 0.2 2.20189013585351 0.149807580840433 0.648702631072087 GO:0031681 G-protein beta-subunit binding 4/1693 23/18639 0.173913043478261 1.91468707465523 0.150677991777156 0.648702631072087 GO:0004177 aminopeptidase activity 6/1693 40/18639 0.15 1.65141760189014 0.150919673645751 0.648702631072087 GO:0061791 GTPase motor activity 6/1693 40/18639 0.15 1.65141760189014 0.150919673645751 0.648702631072087 GO:1990606 membrane scission GTPase motor activity 6/1693 40/18639 0.15 1.65141760189014 0.150919673645751 0.648702631072087 GO:0016500 protein-hormone receptor activity 9/1693 67/18639 0.134328358208955 1.47888143452848 0.151457561889373 0.648702631072087 GO:0008276 protein methyltransferase activity 12/1693 95/18639 0.126315789473684 1.39066745422327 0.151812565943841 0.648702631072087 GO:0035254 glutamate receptor binding 7/1693 49/18639 0.142857142857143 1.5727786684668 0.152868936806509 0.650908370501212 GO:0061630 ubiquitin protein ligase activity 38/1693 353/18639 0.107648725212465 1.18515333091266 0.15463656047366 0.656116392150566 GO:0051540 metal cluster binding 10/1693 77/18639 0.12987012987013 1.42979878951527 0.15857104361864 0.670449500212143 GO:0031369 translation initiation factor binding 5/1693 32/18639 0.15625 1.72022666863556 0.160351179355637 0.673251467329416 GO:0051059 NF-kappaB binding 5/1693 32/18639 0.15625 1.72022666863556 0.160351179355637 0.673251467329416 GO:0004857 enzyme inhibitor activity 44/1693 416/18639 0.105769230769231 1.16446112953792 0.16174083279817 0.676728137228455 GO:0140828 metal cation:monoatomic cation antiporter activity 6/1693 41/18639 0.146341463414634 1.61113912379525 0.164108526730592 0.677573971933324 GO:0008236 serine-type peptidase activity 22/1693 194/18639 0.11340206185567 1.24849440692725 0.164202228662115 0.677573971933324 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/1693 24/18639 0.166666666666667 1.8349084465446 0.168628221294969 0.677573971933324 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/1693 24/18639 0.166666666666667 1.8349084465446 0.168628221294969 0.677573971933324 GO:0030552 cAMP binding 4/1693 24/18639 0.166666666666667 1.8349084465446 0.168628221294969 0.677573971933324 GO:0048027 mRNA 5'-UTR binding 4/1693 24/18639 0.166666666666667 1.8349084465446 0.168628221294969 0.677573971933324 GO:0140789 histone phosphatase activity 16/1693 136/18639 0.117647058823529 1.29522949167854 0.171359874158415 0.677573971933324 GO:0016279 protein-lysine N-methyltransferase activity 9/1693 69/18639 0.130434782608696 1.43601530599142 0.171694897802406 0.677573971933324 GO:0019888 protein phosphatase regulator activity 13/1693 107/18639 0.121495327102804 1.3375968114998 0.17207498463047 0.677573971933324 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0004708 MAP kinase kinase activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0005024 transforming growth factor beta receptor activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0015923 mannosidase activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0019841 retinol binding 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0030275 LRR domain binding 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0043023 ribosomal large subunit binding 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0140327 flippase activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0140328 floppase activity 3/1693 16/18639 0.1875 2.06427200236267 0.172626729778863 0.677573971933324 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/1693 60/18639 0.133333333333333 1.46792675723568 0.174801011125129 0.679633841326717 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/1693 60/18639 0.133333333333333 1.46792675723568 0.174801011125129 0.679633841326717 GO:0019208 phosphatase regulator activity 14/1693 117/18639 0.11965811965812 1.31737016674997 0.174843560839238 0.679633841326717 GO:0140311 protein sequestering activity 5/1693 33/18639 0.151515151515152 1.66809858776781 0.175806911523226 0.68118112021057 GO:0019783 ubiquitin-like protein peptidase activity 15/1693 127/18639 0.118110236220472 1.30032882038593 0.177021466190049 0.683688675509644 GO:0051879 Hsp90 protein binding 6/1693 42/18639 0.142857142857143 1.5727786684668 0.177766662723751 0.684373254255974 GO:0015085 calcium ion transmembrane transporter activity 17/1693 147/18639 0.115646258503401 1.27320177923503 0.180010888904269 0.690806118247273 GO:0016278 lysine N-methyltransferase activity 9/1693 70/18639 0.128571428571429 1.41550080162012 0.182259319229198 0.697214221178362 GO:0019905 syntaxin binding 8/1693 61/18639 0.131147540983607 1.44386238416624 0.186308980514229 0.709542690086639 GO:0017056 structural constituent of nuclear pore 4/1693 25/18639 0.16 1.76151210868281 0.187281417093656 0.709542690086639 GO:0019211 phosphatase activator activity 4/1693 25/18639 0.16 1.76151210868281 0.187281417093656 0.709542690086639 GO:0017171 serine hydrolase activity 22/1693 198/18639 0.111111111111111 1.2232722976964 0.1886907416513 0.709542690086639 GO:0005080 protein kinase C binding 7/1693 52/18639 0.134615384615385 1.48204143759371 0.189690166204745 0.709542690086639 GO:0008376 acetylgalactosaminyltransferase activity 5/1693 34/18639 0.147058823529412 1.61903686459817 0.191798865425326 0.709542690086639 GO:0052866 phosphatidylinositol phosphate phosphatase activity 5/1693 34/18639 0.147058823529412 1.61903686459817 0.191798865425326 0.709542690086639 GO:0090482 vitamin transmembrane transporter activity 5/1693 34/18639 0.147058823529412 1.61903686459817 0.191798865425326 0.709542690086639 GO:0048156 tau protein binding 6/1693 43/18639 0.13953488372093 1.53620242036292 0.191864085215698 0.709542690086639 GO:0019210 kinase inhibitor activity 11/1693 90/18639 0.122222222222222 1.34559952746604 0.192120306403881 0.709542690086639 GO:0035591 signaling adaptor activity 15/1693 129/18639 0.116279069767442 1.28016868363576 0.192732399141273 0.709542690086639 GO:0140101 catalytic activity, acting on a tRNA 16/1693 139/18639 0.115107913669065 1.26727489833296 0.193891941734397 0.709542690086639 GO:0140767 enzyme-substrate adaptor activity 16/1693 139/18639 0.115107913669065 1.26727489833296 0.193891941734397 0.709542690086639 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/1693 17/18639 0.176470588235294 1.94284423751781 0.196339137567969 0.709542690086639 GO:0005092 GDP-dissociation inhibitor activity 3/1693 17/18639 0.176470588235294 1.94284423751781 0.196339137567969 0.709542690086639 GO:0016805 dipeptidase activity 3/1693 17/18639 0.176470588235294 1.94284423751781 0.196339137567969 0.709542690086639 GO:0017110 nucleoside diphosphate phosphatase activity 3/1693 17/18639 0.176470588235294 1.94284423751781 0.196339137567969 0.709542690086639 GO:0051787 misfolded protein binding 3/1693 17/18639 0.176470588235294 1.94284423751781 0.196339137567969 0.709542690086639 GO:0005543 phospholipid binding 51/1693 497/18639 0.10261569416499 1.12974242382826 0.196669924057209 0.709542690086639 GO:0019902 phosphatase binding 21/1693 190/18639 0.110526315789474 1.21683402244536 0.202057111552722 0.726802446032925 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/1693 26/18639 0.153846153846154 1.69376164296424 0.206554870780323 0.72872816757386 GO:0005160 transforming growth factor beta receptor binding 4/1693 26/18639 0.153846153846154 1.69376164296424 0.206554870780323 0.72872816757386 GO:0043548 phosphatidylinositol 3-kinase binding 4/1693 26/18639 0.153846153846154 1.69376164296424 0.206554870780323 0.72872816757386 GO:0004540 RNA nuclease activity 14/1693 121/18639 0.115702479338843 1.27382073974997 0.208118208323814 0.72872816757386 GO:0043178 alcohol binding 11/1693 92/18639 0.119565217391304 1.31634736382547 0.21187182335117 0.72872816757386 GO:0008238 exopeptidase activity 12/1693 102/18639 0.117647058823529 1.29522949167854 0.21418120119699 0.72872816757386 GO:0043539 protein serine/threonine kinase activator activity 9/1693 73/18639 0.123287671232877 1.35732953580011 0.215589569471578 0.72872816757386 GO:0008135 translation factor activity, RNA binding 10/1693 83/18639 0.120481927710843 1.32643984087561 0.219385222183523 0.72872816757386 GO:0030165 PDZ domain binding 10/1693 83/18639 0.120481927710843 1.32643984087561 0.219385222183523 0.72872816757386 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0008525 phosphatidylcholine transporter activity 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0015172 acidic amino acid transmembrane transporter activity 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0070628 proteasome binding 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:1901611 phosphatidylglycerol binding 3/1693 18/18639 0.166666666666667 1.8349084465446 0.220774301380116 0.72872816757386 GO:0051539 4 iron, 4 sulfur cluster binding 6/1693 45/18639 0.133333333333333 1.46792675723568 0.221249402213874 0.72872816757386 GO:0004536 DNA nuclease activity 8/1693 64/18639 0.125 1.37618133490845 0.222640768743544 0.72872816757386 GO:0140030 modification-dependent protein binding 19/1693 173/18639 0.109826589595376 1.20913042142245 0.224517796127449 0.72872816757386 GO:0016409 palmitoyltransferase activity 5/1693 36/18639 0.138888888888889 1.5290903721205 0.225196760775333 0.72872816757386 GO:0005044 scavenger receptor activity 4/1693 27/18639 0.148148148148148 1.63102973026186 0.226365200131763 0.72872816757386 GO:0023026 MHC class II protein complex binding 4/1693 27/18639 0.148148148148148 1.63102973026186 0.226365200131763 0.72872816757386 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/1693 27/18639 0.148148148148148 1.63102973026186 0.226365200131763 0.72872816757386 GO:0035255 ionotropic glutamate receptor binding 4/1693 27/18639 0.148148148148148 1.63102973026186 0.226365200131763 0.72872816757386 GO:0004382 GDP phosphatase activity 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0005528 FK506 binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0008239 dipeptidyl-peptidase activity 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0030957 Tat protein binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0031996 thioesterase binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0033204 ribonuclease P RNA binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0035256 G protein-coupled glutamate receptor binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0043422 protein kinase B binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/1693 10/18639 0.2 2.20189013585351 0.228596885761759 0.72872816757386 GO:0051117 ATPase binding 10/1693 84/18639 0.119047619047619 1.310648890389 0.230332192792074 0.728795276319707 GO:0180051 translation factor activity 10/1693 84/18639 0.119047619047619 1.310648890389 0.230332192792074 0.728795276319707 GO:0008017 microtubule binding 29/1693 276/18639 0.105072463768116 1.1567901076042 0.230432365375774 0.728795276319707 GO:0042562 hormone binding 11/1693 94/18639 0.117021276595745 1.28833997310578 0.232429527267964 0.733187383135856 GO:0004674 protein serine/threonine kinase activity 44/1693 433/18639 0.10161662817552 1.11874325609185 0.236769010786006 0.744925999992527 GO:0044183 protein folding chaperone 9/1693 75/18639 0.12 1.32113408151211 0.239038003899198 0.750106236194097 GO:0106310 protein serine kinase activity 37/1693 361/18639 0.102493074792244 1.12839245189169 0.242261259351555 0.755079085117319 GO:0019213 deacetylase activity 5/1693 37/18639 0.135135135135135 1.48776360530643 0.242502577543903 0.755079085117319 GO:0030551 cyclic nucleotide binding 5/1693 37/18639 0.135135135135135 1.48776360530643 0.242502577543903 0.755079085117319 GO:0101005 deubiquitinase activity 13/1693 115/18639 0.11304347826087 1.2445465985259 0.244084017363568 0.756204515599106 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 28/1693 268/18639 0.104477611940299 1.15024111574437 0.244632235391873 0.756204515599106 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/1693 19/18639 0.157894736842105 1.73833431777909 0.245768970211887 0.756204515599106 GO:0042800 histone H3K4 methyltransferase activity 3/1693 19/18639 0.157894736842105 1.73833431777909 0.245768970211887 0.756204515599106 GO:0050698 proteoglycan sulfotransferase activity 4/1693 28/18639 0.142857142857143 1.5727786684668 0.246629356539791 0.756204515599106 GO:0051537 2 iron, 2 sulfur cluster binding 4/1693 28/18639 0.142857142857143 1.5727786684668 0.246629356539791 0.756204515599106 GO:0004252 serine-type endopeptidase activity 19/1693 176/18639 0.107954545454545 1.18852024378457 0.247493958008999 0.756929490865087 GO:0016758 hexosyltransferase activity 21/1693 197/18639 0.106598984771574 1.17359626530263 0.251776602533591 0.761783734927808 GO:0005504 fatty acid binding 6/1693 47/18639 0.127659574468085 1.40546178884267 0.251998871757681 0.761783734927808 GO:0140359 ABC-type transporter activity 6/1693 47/18639 0.127659574468085 1.40546178884267 0.251998871757681 0.761783734927808 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 18/1693 167/18639 0.107784431137725 1.18664737860369 0.257057421589969 0.761783734927808 GO:0015631 tubulin binding 39/1693 385/18639 0.101298701298701 1.11524305582191 0.258927059857313 0.761783734927808 GO:0042054 histone methyltransferase activity 8/1693 67/18639 0.119402985074627 1.31456127513643 0.261306401735756 0.761783734927808 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0008172 S-methyltransferase activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0008526 phosphatidylinositol transfer activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0019107 myristoyltransferase activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0019206 nucleoside kinase activity 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0032050 clathrin heavy chain binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0032794 GTPase activating protein binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0034713 type I transforming growth factor beta receptor binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0042608 T cell receptor binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0048185 activin binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0070697 activin receptor binding 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/1693 11/18639 0.181818181818182 2.00171830532138 0.263621425282071 0.761783734927808 GO:0004518 nuclease activity 22/1693 209/18639 0.105263157894737 1.15888954518606 0.26454647209614 0.762627987741265 GO:0004181 metallocarboxypeptidase activity 4/1693 29/18639 0.137931034482759 1.51854492127829 0.267265499751067 0.76316333459724 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/1693 29/18639 0.137931034482759 1.51854492127829 0.267265499751067 0.76316333459724 GO:0097472 cyclin-dependent protein kinase activity 4/1693 29/18639 0.137931034482759 1.51854492127829 0.267265499751067 0.76316333459724 GO:0099604 ligand-gated calcium channel activity 4/1693 29/18639 0.137931034482759 1.51854492127829 0.267265499751067 0.76316333459724 GO:0000339 RNA cap binding 3/1693 20/18639 0.15 1.65141760189014 0.271168714708998 0.765241923242021 GO:0001972 retinoic acid binding 3/1693 20/18639 0.15 1.65141760189014 0.271168714708998 0.765241923242021 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 3/1693 20/18639 0.15 1.65141760189014 0.271168714708998 0.765241923242021 GO:0016505 peptidase activator activity involved in apoptotic process 3/1693 20/18639 0.15 1.65141760189014 0.271168714708998 0.765241923242021 GO:0031418 L-ascorbic acid binding 3/1693 20/18639 0.15 1.65141760189014 0.271168714708998 0.765241923242021 GO:0005548 phospholipid transporter activity 8/1693 68/18639 0.117647058823529 1.29522949167854 0.274624065304467 0.771676420337979 GO:0004843 cysteine-type deubiquitinase activity 12/1693 108/18639 0.111111111111111 1.2232722976964 0.274833212693529 0.771676420337979 GO:0008170 N-methyltransferase activity 11/1693 98/18639 0.112244897959184 1.23575466808105 0.275645517575777 0.771676420337979 GO:0004197 cysteine-type endopeptidase activity 10/1693 88/18639 0.113636363636364 1.25107394082586 0.276010404286862 0.771676420337979 GO:0140097 catalytic activity, acting on DNA 34/1693 336/18639 0.101190476190476 1.11405155683065 0.278286108303666 0.776237871541475 GO:0016763 pentosyltransferase activity 6/1693 49/18639 0.122448979591837 1.34809600154297 0.283835575806464 0.778104670720545 GO:0099106 ion channel regulator activity 17/1693 160/18639 0.10625 1.16975413467218 0.284522846646093 0.778104670720545 GO:0001786 phosphatidylserine binding 7/1693 59/18639 0.11864406779661 1.30620601279446 0.286819080063891 0.778104670720545 GO:0036002 pre-mRNA binding 7/1693 59/18639 0.11864406779661 1.30620601279446 0.286819080063891 0.778104670720545 GO:0070888 E-box binding 7/1693 59/18639 0.11864406779661 1.30620601279446 0.286819080063891 0.778104670720545 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 19/1693 181/18639 0.104972375690608 1.15568819285129 0.287740641348923 0.778104670720545 GO:0003727 single-stranded RNA binding 10/1693 89/18639 0.112359550561798 1.23701693025478 0.287838367190199 0.778104670720545 GO:0002039 p53 binding 8/1693 69/18639 0.115942028985507 1.27645804977015 0.288122972517852 0.778104670720545 GO:0031210 phosphatidylcholine binding 4/1693 30/18639 0.133333333333333 1.46792675723568 0.288193745936041 0.778104670720545 GO:0031624 ubiquitin conjugating enzyme binding 4/1693 30/18639 0.133333333333333 1.46792675723568 0.288193745936041 0.778104670720545 GO:0070566 adenylyltransferase activity 4/1693 30/18639 0.133333333333333 1.46792675723568 0.288193745936041 0.778104670720545 GO:0008373 sialyltransferase activity 3/1693 21/18639 0.142857142857143 1.5727786684668 0.296829018376793 0.778104670720545 GO:0009975 cyclase activity 3/1693 21/18639 0.142857142857143 1.5727786684668 0.296829018376793 0.778104670720545 GO:0000340 RNA 7-methylguanosine cap binding 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0005025 transforming growth factor beta receptor activity, type I 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0005026 transforming growth factor beta receptor activity, type II 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0005078 MAP-kinase scaffold activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0005527 macrolide binding 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0016361 activin receptor activity, type I 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0016362 activin receptor activity, type II 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0016423 tRNA (guanine) methyltransferase activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0017002 activin receptor activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0042301 phosphate ion binding 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0045295 gamma-catenin binding 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1693 12/18639 0.166666666666667 1.8349084465446 0.298651041367593 0.778104670720545 GO:0015605 organophosphate ester transmembrane transporter activity 6/1693 50/18639 0.12 1.32113408151211 0.300073991614202 0.778104670720545 GO:0032813 tumor necrosis factor receptor superfamily binding 6/1693 50/18639 0.12 1.32113408151211 0.300073991614202 0.778104670720545 GO:0019207 kinase regulator activity 29/1693 287/18639 0.101045296167247 1.11245320452529 0.300264457995895 0.778104670720545 GO:0005262 calcium channel activity 14/1693 131/18639 0.106870229007634 1.17658251534157 0.30168136117557 0.778428351641459 GO:0031072 heat shock protein binding 14/1693 131/18639 0.106870229007634 1.17658251534157 0.30168136117557 0.778428351641459 GO:0005164 tumor necrosis factor receptor binding 4/1693 31/18639 0.129032258064516 1.42057428119582 0.309336796517885 0.789726355517057 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/1693 31/18639 0.129032258064516 1.42057428119582 0.309336796517885 0.789726355517057 GO:0008327 methyl-CpG binding 4/1693 31/18639 0.129032258064516 1.42057428119582 0.309336796517885 0.789726355517057 GO:0070273 phosphatidylinositol-4-phosphate binding 4/1693 31/18639 0.129032258064516 1.42057428119582 0.309336796517885 0.789726355517057 GO:0070325 lipoprotein particle receptor binding 4/1693 31/18639 0.129032258064516 1.42057428119582 0.309336796517885 0.789726355517057 GO:0001217 DNA-binding transcription repressor activity 28/1693 278/18639 0.100719424460432 1.10886553604134 0.310522294793264 0.791076882084321 GO:0030971 receptor tyrosine kinase binding 9/1693 81/18639 0.111111111111111 1.2232722976964 0.313948359189309 0.793685806358742 GO:0042393 histone binding 25/1693 247/18639 0.101214574898785 1.11431687037121 0.314408916028991 0.793685806358742 GO:0042287 MHC protein binding 5/1693 41/18639 0.121951219512195 1.34261593649605 0.314590762039107 0.793685806358742 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/1693 41/18639 0.121951219512195 1.34261593649605 0.314590762039107 0.793685806358742 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 13/1693 122/18639 0.10655737704918 1.17313818713507 0.314839680862638 0.793685806358742 GO:0005048 signal sequence binding 6/1693 51/18639 0.117647058823529 1.29522949167854 0.316479255419104 0.796153450480209 GO:0034062 5'-3' RNA polymerase activity 3/1693 22/18639 0.136363636363636 1.50128872899103 0.32261597618858 0.80653994047145 GO:0050321 tau-protein kinase activity 3/1693 22/18639 0.136363636363636 1.50128872899103 0.32261597618858 0.80653994047145 GO:0097747 RNA polymerase activity 3/1693 22/18639 0.136363636363636 1.50128872899103 0.32261597618858 0.80653994047145 GO:0051087 protein-folding chaperone binding 14/1693 134/18639 0.104477611940299 1.15024111574437 0.33190166108293 0.813243293011729 GO:0019894 kinesin binding 5/1693 42/18639 0.119047619047619 1.310648890389 0.333080505189831 0.813243293011729 GO:0031492 nucleosomal DNA binding 5/1693 42/18639 0.119047619047619 1.310648890389 0.333080505189831 0.813243293011729 GO:0035198 miRNA binding 5/1693 42/18639 0.119047619047619 1.310648890389 0.333080505189831 0.813243293011729 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0005172 vascular endothelial growth factor receptor binding 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0009982 pseudouridine synthase activity 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0019104 DNA N-glycosylase activity 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0031994 insulin-like growth factor I binding 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0070123 transforming growth factor beta receptor activity, type III 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0140852 histone ubiquitin ligase activity 2/1693 13/18639 0.153846153846154 1.69376164296424 0.333396005599829 0.813243293011729 GO:0008194 UDP-glycosyltransferase activity 15/1693 145/18639 0.103448275862069 1.13890869095871 0.337735143085206 0.822163328116512 GO:0008234 cysteine-type peptidase activity 19/1693 187/18639 0.101604278074866 1.11860728826783 0.338621887164648 0.822660028293147 GO:0015297 antiporter activity 14/1693 135/18639 0.103703703703704 1.1417208111833 0.342126659799195 0.828376422667785 GO:0004521 RNA endonuclease activity 8/1693 73/18639 0.10958904109589 1.20651514293343 0.343523732329927 0.828376422667785 GO:0005507 copper ion binding 7/1693 63/18639 0.111111111111111 1.2232722976964 0.346807386024887 0.828376422667785 GO:1901682 sulfur compound transmembrane transporter activity 7/1693 63/18639 0.111111111111111 1.2232722976964 0.346807386024887 0.828376422667785 GO:0140597 protein carrier chaperone 19/1693 188/18639 0.101063829787234 1.11265724950045 0.347314082482731 0.828376422667785 GO:0003887 DNA-directed DNA polymerase activity 3/1693 23/18639 0.130434782608696 1.43601530599142 0.348406673850293 0.828376422667785 GO:0016849 phosphorus-oxygen lyase activity 3/1693 23/18639 0.130434782608696 1.43601530599142 0.348406673850293 0.828376422667785 GO:0017134 fibroblast growth factor binding 3/1693 23/18639 0.130434782608696 1.43601530599142 0.348406673850293 0.828376422667785 GO:0043274 phospholipase binding 3/1693 23/18639 0.130434782608696 1.43601530599142 0.348406673850293 0.828376422667785 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/1693 23/18639 0.130434782608696 1.43601530599142 0.348406673850293 0.828376422667785 GO:0005246 calcium channel regulator activity 6/1693 53/18639 0.113207547169811 1.2463529070869 0.349653318208543 0.828376422667785 GO:0017046 peptide hormone binding 6/1693 53/18639 0.113207547169811 1.2463529070869 0.349653318208543 0.828376422667785 GO:0004712 protein serine/threonine/tyrosine kinase activity 5/1693 43/18639 0.116279069767442 1.28016868363576 0.351661613081164 0.828376422667785 GO:0005245 voltage-gated calcium channel activity 5/1693 43/18639 0.116279069767442 1.28016868363576 0.351661613081164 0.828376422667785 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1693 43/18639 0.116279069767442 1.28016868363576 0.351661613081164 0.828376422667785 GO:0140416 transcription regulator inhibitor activity 4/1693 33/18639 0.121212121212121 1.33447887021425 0.351974048469631 0.828376422667785 GO:0008094 ATP-dependent activity, acting on DNA 21/1693 210/18639 0.1 1.10094506792676 0.354776927881314 0.83334541539373 GO:0016247 channel regulator activity 17/1693 168/18639 0.101190476190476 1.11405155683065 0.357026296875382 0.835147936269371 GO:0035064 methylated histone binding 8/1693 74/18639 0.108108108108108 1.19021088424514 0.357623514618253 0.835147936269371 GO:0048029 monosaccharide binding 8/1693 74/18639 0.108108108108108 1.19021088424514 0.357623514618253 0.835147936269371 GO:0005313 L-glutamate transmembrane transporter activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0005545 1-phosphatidylinositol binding 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0008559 ABC-type xenobiotic transporter activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0015386 potassium:proton antiporter activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0032036 myosin heavy chain binding 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0042043 neurexin family protein binding 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0044548 S100 protein binding 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0061665 SUMO ligase activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0098821 BMP receptor activity 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:1901612 cardiolipin binding 2/1693 14/18639 0.142857142857143 1.5727786684668 0.367619123824122 0.840297645232359 GO:0001046 core promoter sequence-specific DNA binding 5/1693 44/18639 0.113636363636364 1.25107394082586 0.370288837857579 0.840297645232359 GO:0003954 NADH dehydrogenase activity 5/1693 44/18639 0.113636363636364 1.25107394082586 0.370288837857579 0.840297645232359 GO:0016790 thiolester hydrolase activity 5/1693 44/18639 0.113636363636364 1.25107394082586 0.370288837857579 0.840297645232359 GO:0030547 signaling receptor inhibitor activity 5/1693 44/18639 0.113636363636364 1.25107394082586 0.370288837857579 0.840297645232359 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/1693 34/18639 0.117647058823529 1.29522949167854 0.373330739542206 0.843404171875421 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1693 24/18639 0.125 1.37618133490845 0.374089309929626 0.843404171875421 GO:0070840 dynein complex binding 3/1693 24/18639 0.125 1.37618133490845 0.374089309929626 0.843404171875421 GO:0019887 protein kinase regulator activity 25/1693 255/18639 0.0980392156862745 1.07935790973211 0.374457453903195 0.843404171875421 GO:0141108 transporter regulator activity 17/1693 170/18639 0.1 1.10094506792676 0.375725785453151 0.84468203632658 GO:0160215 deacylase activity 7/1693 65/18639 0.107692307692308 1.18563315007497 0.37735463908111 0.846764134250907 GO:0031490 chromatin DNA binding 13/1693 128/18639 0.1015625 1.11814733461311 0.379036834867463 0.848957966571177 GO:0140034 methylation-dependent protein binding 8/1693 76/18639 0.105263157894737 1.15888954518606 0.385982519934294 0.862910828424535 GO:0140303 intramembrane lipid transporter activity 5/1693 45/18639 0.111111111111111 1.2232722976964 0.388918767313043 0.86786502705966 GO:0008168 methyltransferase activity 20/1693 204/18639 0.0980392156862745 1.07935790973211 0.394163770813255 0.870918834829599 GO:0034061 DNA polymerase activity 4/1693 35/18639 0.114285714285714 1.25822293477344 0.394627776811488 0.870918834829599 GO:0033218 amide binding 24/1693 247/18639 0.097165991902834 1.06974419555636 0.395443120177216 0.870918834829599 GO:0140098 catalytic activity, acting on RNA 37/1693 387/18639 0.0956072351421189 1.05258313987829 0.396291082568631 0.870918834829599 GO:0016741 transferase activity, transferring one-carbon groups 21/1693 215/18639 0.0976744186046512 1.07534169425404 0.396713719630122 0.870918834829599 GO:0003707 nuclear steroid receptor activity 3/1693 25/18639 0.12 1.32113408151211 0.399563113498167 0.870918834829599 GO:0042974 nuclear retinoic acid receptor binding 3/1693 25/18639 0.12 1.32113408151211 0.399563113498167 0.870918834829599 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/1693 25/18639 0.12 1.32113408151211 0.399563113498167 0.870918834829599 GO:0003724 RNA helicase activity 8/1693 77/18639 0.103896103896104 1.14383903161222 0.400202914154894 0.870918834829599 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0005041 low-density lipoprotein particle receptor activity 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0031005 filamin binding 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0048531 beta-1,3-galactosyltransferase activity 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0140776 protein-containing complex destabilizing activity 2/1693 15/18639 0.133333333333333 1.46792675723568 0.401128591975458 0.870918834829599 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/1693 46/18639 0.108695652173913 1.19667942165952 0.407509987968843 0.881597011674068 GO:0030276 clathrin binding 5/1693 46/18639 0.108695652173913 1.19667942165952 0.407509987968843 0.881597011674068 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/1693 36/18639 0.111111111111111 1.2232722976964 0.415806653816007 0.88293060262063 GO:0055106 ubiquitin-protein transferase regulator activity 4/1693 36/18639 0.111111111111111 1.2232722976964 0.415806653816007 0.88293060262063 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/1693 36/18639 0.111111111111111 1.2232722976964 0.415806653816007 0.88293060262063 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/1693 36/18639 0.111111111111111 1.2232722976964 0.415806653816007 0.88293060262063 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/1693 36/18639 0.111111111111111 1.2232722976964 0.415806653816007 0.88293060262063 GO:1901981 phosphatidylinositol phosphate binding 18/1693 185/18639 0.0972972972972973 1.07118979582063 0.415948526149564 0.88293060262063 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/1693 57/18639 0.105263157894737 1.15888954518606 0.416539117234797 0.88293060262063 GO:0051082 unfolded protein binding 12/1693 121/18639 0.0991735537190083 1.09184634835711 0.419419424281638 0.88293060262063 GO:1990841 promoter-specific chromatin binding 7/1693 68/18639 0.102941176470588 1.13332580521872 0.423312206383811 0.88293060262063 GO:0005112 Notch binding 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0008066 glutamate receptor activity 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0008143 poly(A) binding 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0030507 spectrin binding 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0050681 nuclear androgen receptor binding 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0050750 low-density lipoprotein particle receptor binding 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0051139 metal cation:proton antiporter activity 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0052742 phosphatidylinositol kinase activity 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0120014 phospholipid transfer activity 3/1693 26/18639 0.115384615384615 1.27032123222318 0.424738101678756 0.88293060262063 GO:0001784 phosphotyrosine residue binding 5/1693 47/18639 0.106382978723404 1.17121815736889 0.42602321608922 0.88293060262063 GO:0043495 protein-membrane adaptor activity 5/1693 47/18639 0.106382978723404 1.17121815736889 0.42602321608922 0.88293060262063 GO:0140938 histone H3 methyltransferase activity 5/1693 47/18639 0.106382978723404 1.17121815736889 0.42602321608922 0.88293060262063 GO:1902936 phosphatidylinositol bisphosphate binding 11/1693 111/18639 0.0990990990990991 1.09102664389138 0.427653173728445 0.88293060262063 GO:0005506 iron ion binding 15/1693 154/18639 0.0974025974025974 1.07234909213645 0.428099201847099 0.88293060262063 GO:0008186 ATP-dependent activity, acting on RNA 8/1693 79/18639 0.10126582278481 1.11488108144482 0.428631618682441 0.88293060262063 GO:0033293 monocarboxylic acid binding 8/1693 79/18639 0.10126582278481 1.11488108144482 0.428631618682441 0.88293060262063 GO:0008408 3'-5' exonuclease activity 6/1693 58/18639 0.103448275862069 1.13890869095871 0.433193348358581 0.88293060262063 GO:0000062 fatty-acyl-CoA binding 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0004707 MAP kinase activity 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0008142 oxysterol binding 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0015385 sodium:proton antiporter activity 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0015562 efflux transmembrane transporter activity 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0017070 U6 snRNA binding 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0034450 ubiquitin-ubiquitin ligase activity 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1693 16/18639 0.125 1.37618133490845 0.433771715146401 0.88293060262063 GO:0022829 wide pore channel activity 4/1693 37/18639 0.108108108108108 1.19021088424514 0.436813208515656 0.887622118484596 GO:0004386 helicase activity 15/1693 155/18639 0.0967741935483871 1.06543071089686 0.438237517151584 0.88901718546744 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1693 48/18639 0.104166666666667 1.14681777909037 0.444421398832112 0.900046698475117 GO:0072341 modified amino acid binding 9/1693 91/18639 0.0989010989010989 1.08884677047701 0.446237098857502 0.90027515679469 GO:0016887 ATP hydrolysis activity 39/1693 417/18639 0.0935251798561151 1.02966085489553 0.44842370527693 0.90027515679469 GO:0005385 zinc ion transmembrane transporter activity 3/1693 27/18639 0.111111111111111 1.2232722976964 0.449534714372129 0.90027515679469 GO:0008395 steroid hydroxylase activity 3/1693 27/18639 0.111111111111111 1.2232722976964 0.449534714372129 0.90027515679469 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1693 27/18639 0.111111111111111 1.2232722976964 0.449534714372129 0.90027515679469 GO:0031593 polyubiquitin modification-dependent protein binding 6/1693 59/18639 0.101694915254237 1.11960515382382 0.449764020240998 0.90027515679469 GO:0045309 protein phosphorylated amino acid binding 6/1693 59/18639 0.101694915254237 1.11960515382382 0.449764020240998 0.90027515679469 GO:0001618 virus receptor activity 8/1693 81/18639 0.0987654320987654 1.08735315350791 0.4569250494859 0.911413528542095 GO:0005109 frizzled binding 4/1693 38/18639 0.105263157894737 1.15888954518606 0.457597663707857 0.911413528542095 GO:0043531 ADP binding 4/1693 38/18639 0.105263157894737 1.15888954518606 0.457597663707857 0.911413528542095 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0015278 intracellularly gated calcium channel activity 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0030169 low-density lipoprotein particle binding 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0045236 CXCR chemokine receptor binding 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0048038 quinone binding 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0070402 NADPH binding 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:1901567 fatty acid derivative binding 2/1693 17/18639 0.117647058823529 1.29522949167854 0.465429392156858 0.916409179001656 GO:0140658 ATP-dependent chromatin remodeler activity 15/1693 158/18639 0.0949367088607595 1.04520101385452 0.468595925149969 0.918053770998347 GO:0030414 peptidase inhibitor activity 16/1693 169/18639 0.0946745562130177 1.04231485720876 0.469554378086514 0.918053770998347 GO:0140272 exogenous protein binding 8/1693 82/18639 0.0975609756097561 1.07409274919684 0.470978554176086 0.918053770998347 GO:0051213 dioxygenase activity 9/1693 93/18639 0.0967741935483871 1.06543071089686 0.472671442162484 0.918053770998347 GO:0005242 inward rectifier potassium channel activity 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0016866 intramolecular transferase activity 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0046625 sphingolipid binding 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0046966 nuclear thyroid hormone receptor binding 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0051959 dynein light intermediate chain binding 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/1693 28/18639 0.107142857142857 1.1795840013501 0.47388335731201 0.918053770998347 GO:0019209 kinase activator activity 14/1693 148/18639 0.0945945945945946 1.0414345237145 0.477975120385799 0.923282233592332 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1693 39/18639 0.102564102564103 1.12917442864283 0.478114617229556 0.923282233592332 GO:0035403 histone H3T6 kinase activity 23/1693 247/18639 0.0931174089068826 1.02517152074151 0.482385057472175 0.923707832484916 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1693 61/18639 0.0983606557377049 1.08289678812468 0.482552155654486 0.923707832484916 GO:0008514 organic anion transmembrane transporter activity 25/1693 269/18639 0.0929368029739777 1.02318314863082 0.482996206307381 0.923707832484916 GO:0004519 endonuclease activity 12/1693 127/18639 0.094488188976378 1.04026305630875 0.487573947957405 0.923707832484916 GO:0003746 translation elongation factor activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0004970 glutamate-gated receptor activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0008308 voltage-gated monoatomic anion channel activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0017075 syntaxin-1 binding 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0017128 phospholipid scramblase activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0030228 lipoprotein particle receptor activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0034185 apolipoprotein binding 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0035615 clathrin adaptor activity 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0050811 GABA receptor binding 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0070064 proline-rich region binding 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:1990381 ubiquitin-specific protease binding 2/1693 18/18639 0.111111111111111 1.2232722976964 0.496011278503951 0.923707832484916 GO:0035250 UDP-galactosyltransferase activity 3/1693 29/18639 0.103448275862069 1.13890869095871 0.497723879338272 0.923707832484916 GO:0051861 glycolipid binding 3/1693 29/18639 0.103448275862069 1.13890869095871 0.497723879338272 0.923707832484916 GO:0106222 lncRNA binding 3/1693 29/18639 0.103448275862069 1.13890869095871 0.497723879338272 0.923707832484916 GO:0004532 RNA exonuclease activity 4/1693 40/18639 0.1 1.10094506792676 0.498322989151916 0.923707832484916 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1693 40/18639 0.1 1.10094506792676 0.498322989151916 0.923707832484916 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1693 40/18639 0.1 1.10094506792676 0.498322989151916 0.923707832484916 GO:0050997 quaternary ammonium group binding 4/1693 40/18639 0.1 1.10094506792676 0.498322989151916 0.923707832484916 GO:0071949 FAD binding 4/1693 40/18639 0.1 1.10094506792676 0.498322989151916 0.923707832484916 GO:0030544 Hsp70 protein binding 5/1693 51/18639 0.0980392156862745 1.07935790973211 0.498589979995383 0.923707832484916 GO:0004866 endopeptidase inhibitor activity 15/1693 161/18639 0.093167701863354 1.0257252185653 0.498736757684265 0.923707832484916 GO:0061135 endopeptidase regulator activity 17/1693 184/18639 0.0923913043478261 1.01717750841059 0.508045130343284 0.923707832484916 GO:0008083 growth factor activity 15/1693 162/18639 0.0925925925925926 1.01939358141366 0.508707033026101 0.923707832484916 GO:0000510 H3-H4 histone complex chaperone activity 14/1693 151/18639 0.0927152317880795 1.02074377158772 0.509085756209751 0.923707832484916 GO:0140584 chromatin extrusion motor activity 14/1693 151/18639 0.0927152317880795 1.02074377158772 0.509085756209751 0.923707832484916 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 14/1693 151/18639 0.0927152317880795 1.02074377158772 0.509085756209751 0.923707832484916 GO:0140849 ATP-dependent H2AZ histone chaperone activity 14/1693 151/18639 0.0927152317880795 1.02074377158772 0.509085756209751 0.923707832484916 GO:0001727 lipid kinase activity 4/1693 41/18639 0.0975609756097561 1.07409274919684 0.518185932623571 0.923707832484916 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/1693 41/18639 0.0975609756097561 1.07409274919684 0.518185932623571 0.923707832484916 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1693 41/18639 0.0975609756097561 1.07409274919684 0.518185932623571 0.923707832484916 GO:0016877 ligase activity, forming carbon-sulfur bonds 4/1693 41/18639 0.0975609756097561 1.07409274919684 0.518185932623571 0.923707832484916 GO:0017080 sodium channel regulator activity 4/1693 41/18639 0.0975609756097561 1.07409274919684 0.518185932623571 0.923707832484916 GO:0015616 DNA translocase activity 14/1693 152/18639 0.0921052631578947 1.0140283520378 0.519357704749645 0.923707832484916 GO:0140674 ATP-dependent histone chaperone activity 14/1693 152/18639 0.0921052631578947 1.0140283520378 0.519357704749645 0.923707832484916 GO:0001968 fibronectin binding 3/1693 30/18639 0.1 1.10094506792676 0.521005005271854 0.923707832484916 GO:0015215 nucleotide transmembrane transporter activity 3/1693 30/18639 0.1 1.10094506792676 0.521005005271854 0.923707832484916 GO:0033612 receptor serine/threonine kinase binding 3/1693 30/18639 0.1 1.10094506792676 0.521005005271854 0.923707832484916 GO:0048019 receptor antagonist activity 3/1693 30/18639 0.1 1.10094506792676 0.521005005271854 0.923707832484916 GO:0005496 steroid binding 10/1693 108/18639 0.0925925925925926 1.01939358141366 0.523260446938887 0.923707832484916 GO:0000287 magnesium ion binding 21/1693 230/18639 0.091304347826087 1.005210714194 0.523736248875199 0.923707832484916 GO:0003756 protein disulfide isomerase activity 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0005520 insulin-like growth factor binding 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0008574 plus-end-directed microtubule motor activity 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0030506 ankyrin binding 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0046527 glucosyltransferase activity 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0046624 sphingolipid transporter activity 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0120227 acyl-CoA binding 2/1693 19/18639 0.105263157894737 1.15888954518606 0.525451550067723 0.923707832484916 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 8/1693 86/18639 0.0930232558139535 1.02413494690861 0.526209228373971 0.923707832484916 GO:0050660 flavin adenine dinucleotide binding 8/1693 86/18639 0.0930232558139535 1.02413494690861 0.526209228373971 0.923707832484916 GO:0001664 G protein-coupled receptor binding 27/1693 297/18639 0.0909090909090909 1.00085915266069 0.527983815697098 0.923707832484916 GO:0140713 histone chaperone activity 15/1693 164/18639 0.0914634146341463 1.00696195237203 0.528498112648901 0.923707832484916 GO:0061775 cohesin loader activity 14/1693 153/18639 0.0915032679738562 1.00740071574997 0.529570184793331 0.923707832484916 GO:0004864 protein phosphatase inhibitor activity 5/1693 53/18639 0.0943396226415094 1.03862742257241 0.533553173745862 0.923707832484916 GO:0005544 calcium-dependent phospholipid binding 5/1693 53/18639 0.0943396226415094 1.03862742257241 0.533553173745862 0.923707832484916 GO:0008146 sulfotransferase activity 5/1693 53/18639 0.0943396226415094 1.03862742257241 0.533553173745862 0.923707832484916 GO:0016860 intramolecular oxidoreductase activity 5/1693 53/18639 0.0943396226415094 1.03862742257241 0.533553173745862 0.923707832484916 GO:0051015 actin filament binding 19/1693 209/18639 0.0909090909090909 1.00085915266069 0.533813188037564 0.923707832484916 GO:0004620 phospholipase activity 10/1693 109/18639 0.0917431192660551 1.0100413467218 0.535332292229172 0.923707832484916 GO:0042626 ATPase-coupled transmembrane transporter activity 9/1693 98/18639 0.0918367346938776 1.01107200115723 0.537336162004739 0.923707832484916 GO:0008307 structural constituent of muscle 4/1693 42/18639 0.0952380952380952 1.0485191123112 0.537670714458702 0.923707832484916 GO:0016859 cis-trans isomerase activity 4/1693 42/18639 0.0952380952380952 1.0485191123112 0.537670714458702 0.923707832484916 GO:0048487 beta-tubulin binding 4/1693 42/18639 0.0952380952380952 1.0485191123112 0.537670714458702 0.923707832484916 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 22/1693 243/18639 0.0905349794238683 0.996740390715583 0.539361139031353 0.923707832484916 GO:0098631 cell adhesion mediator activity 7/1693 76/18639 0.0921052631578947 1.0140283520378 0.542550241118754 0.923707832484916 GO:0072349 modified amino acid transmembrane transporter activity 3/1693 31/18639 0.0967741935483871 1.06543071089686 0.543683741924064 0.923707832484916 GO:0038024 cargo receptor activity 6/1693 65/18639 0.0923076923076923 1.01625698577855 0.546079706508002 0.923707832484916 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/1693 54/18639 0.0925925925925926 1.01939358141366 0.550614181696051 0.923707832484916 GO:0019903 protein phosphatase binding 13/1693 144/18639 0.0902777777777778 0.993908741878322 0.551726158849336 0.923707832484916 GO:0030742 GTP-dependent protein binding 2/1693 20/18639 0.1 1.10094506792676 0.553705198440915 0.923707832484916 GO:0140939 histone H4 methyltransferase activity 2/1693 20/18639 0.1 1.10094506792676 0.553705198440915 0.923707832484916 GO:0004676 3-phosphoinositide-dependent protein kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0004711 ribosomal protein S6 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0035175 histone H3S10 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0035979 histone H2AXS139 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0044022 histone H3S28 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0044023 histone H4S1 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0044024 histone H2AS1 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0044025 histone H2BS14 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0072354 histone H3T3 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0072371 histone H2AS121 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0072518 Rho-dependent protein serine/threonine kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0140823 histone H2BS36 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0140855 histone H3S57 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0140995 histone H2A kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0140997 histone H4 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0140998 histone H2B kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:1990244 histone H2AT120 kinase activity 22/1693 245/18639 0.0897959183673469 0.988603734464843 0.555431907226221 0.923707832484916 GO:0008375 acetylglucosaminyltransferase activity 4/1693 43/18639 0.0930232558139535 1.02413494690861 0.556748571010244 0.923707832484916 GO:0001216 DNA-binding transcription activator activity 44/1693 491/18639 0.0896130346232179 0.986590284903815 0.561454593551423 0.923707832484916 GO:0004677 DNA-dependent protein kinase activity 22/1693 246/18639 0.0894308943089431 0.9845850200971 0.56340127539125 0.923707832484916 GO:0140857 histone H3T45 kinase activity 22/1693 246/18639 0.0894308943089431 0.9845850200971 0.56340127539125 0.923707832484916 GO:0008378 galactosyltransferase activity 3/1693 32/18639 0.09375 1.03213600118133 0.565724771490779 0.923707832484916 GO:0043425 bHLH transcription factor binding 3/1693 32/18639 0.09375 1.03213600118133 0.565724771490779 0.923707832484916 GO:0071813 lipoprotein particle binding 3/1693 32/18639 0.09375 1.03213600118133 0.565724771490779 0.923707832484916 GO:0071814 protein-lipid complex binding 3/1693 32/18639 0.09375 1.03213600118133 0.565724771490779 0.923707832484916 GO:0098632 cell-cell adhesion mediator activity 5/1693 55/18639 0.0909090909090909 1.00085915266069 0.567366521725165 0.923707832484916 GO:0035402 histone H3T11 kinase activity 22/1693 247/18639 0.0890688259109312 0.980598845926666 0.571322861143337 0.923707832484916 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/1693 67/18639 0.0895522388059701 0.98592095635232 0.576509622915707 0.923707832484916 GO:0004679 AMP-activated protein kinase activity 22/1693 248/18639 0.0887096774193548 0.976644818322123 0.579193933967921 0.923707832484916 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0005123 death receptor binding 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0019200 carbohydrate kinase activity 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0051010 microtubule plus-end binding 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0051428 peptide hormone receptor binding 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0140312 cargo adaptor activity 2/1693 21/18639 0.0952380952380952 1.0485191123112 0.580744796342401 0.923707832484916 GO:0019212 phosphatase inhibitor activity 5/1693 56/18639 0.0892857142857143 0.982986667791748 0.583791798520569 0.923707832484916 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 43/1693 484/18639 0.0888429752066116 0.978112353736582 0.584947979400677 0.923707832484916 GO:0030145 manganese ion binding 6/1693 68/18639 0.0882352941176471 0.971422118758903 0.591335179354278 0.923707832484916 GO:0032934 sterol binding 6/1693 68/18639 0.0882352941176471 0.971422118758903 0.591335179354278 0.923707832484916 GO:0003689 DNA clamp loader activity 14/1693 160/18639 0.0875 0.963326934435913 0.598921798031656 0.923707832484916 GO:0004601 peroxidase activity 5/1693 57/18639 0.087719298245614 0.96574128765505 0.59987378710574 0.923707832484916 GO:0008093 cytoskeletal anchor activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0032931 histone H3K56 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0043992 histone H3K9 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0043993 histone H3K18 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0043994 histone H3K23 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0043999 histone H2AK5 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044012 histone H2AK9 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044014 histone H2BK5 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044015 histone H2BK12 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044016 histone H3K4 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044017 histone H3K27 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0044018 histone H3K36 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0046972 histone H4K16 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0061133 endopeptidase activator activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0140517 protein-RNA adaptor activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0140908 histone H3K122 acetyltransferase activity 2/1693 22/18639 0.0909090909090909 1.00085915266069 0.606557678357783 0.923707832484916 GO:0008175 tRNA methyltransferase activity 3/1693 34/18639 0.0882352941176471 0.971422118758903 0.607787176462315 0.923707832484916 GO:0015035 protein-disulfide reductase activity 3/1693 34/18639 0.0882352941176471 0.971422118758903 0.607787176462315 0.923707832484916 GO:0016831 carboxy-lyase activity 3/1693 34/18639 0.0882352941176471 0.971422118758903 0.607787176462315 0.923707832484916 GO:0051427 hormone receptor binding 3/1693 34/18639 0.0882352941176471 0.971422118758903 0.607787176462315 0.923707832484916 GO:0004180 carboxypeptidase activity 4/1693 46/18639 0.0869565217391304 0.957343537327615 0.611308952114586 0.923707832484916 GO:0001094 TFIID-class transcription factor complex binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0004935 adrenergic receptor activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0005031 tumor necrosis factor receptor activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0005131 growth hormone receptor binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0005381 iron ion transmembrane transporter activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0005522 profilin binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0008140 cAMP response element binding protein binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0008190 eukaryotic initiation factor 4E binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0015203 polyamine transmembrane transporter activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0015279 store-operated calcium channel activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0015643 toxic substance binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0016868 intramolecular phosphotransferase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0019911 structural constituent of myelin sheath 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0031720 haptoglobin binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0032395 MHC class II receptor activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0035374 chondroitin sulfate binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0042975 peroxisome proliferator activated receptor binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0043121 neurotrophin binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0043208 glycosphingolipid binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0050308 sugar-phosphatase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0050815 phosphoserine residue binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0051864 histone H3K36 demethylase activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0097177 mitochondrial ribosome binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0098505 G-rich strand telomeric DNA binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0141109 transporter activator activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:1990757 ubiquitin ligase activator activity 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:1990763 arrestin family protein binding 1/1693 10/18639 0.1 1.10094506792676 0.614218721886996 0.923707832484916 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/1693 58/18639 0.0862068965517241 0.949090575798929 0.615598356798868 0.923707832484916 GO:0061980 regulatory RNA binding 5/1693 58/18639 0.0862068965517241 0.949090575798929 0.615598356798868 0.923707832484916 GO:0030295 protein kinase activator activity 12/1693 139/18639 0.0863309352517986 0.950456173749718 0.616778464608303 0.923707832484916 GO:1990782 protein tyrosine kinase binding 10/1693 117/18639 0.0854700854700855 0.94097869053569 0.627316677168491 0.923707832484916 GO:0000175 3'-5'-RNA exonuclease activity 3/1693 35/18639 0.0857142857142857 0.943667201080078 0.62777087017958 0.923707832484916 GO:0061631 ubiquitin conjugating enzyme activity 3/1693 35/18639 0.0857142857142857 0.943667201080078 0.62777087017958 0.923707832484916 GO:0140566 histone reader activity 3/1693 35/18639 0.0857142857142857 0.943667201080078 0.62777087017958 0.923707832484916 GO:0015459 potassium channel regulator activity 5/1693 59/18639 0.0847457627118644 0.933004294853184 0.630953387961633 0.923707832484916 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/1693 59/18639 0.0847457627118644 0.933004294853184 0.630953387961633 0.923707832484916 GO:0000295 adenine nucleotide transmembrane transporter activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0005212 structural constituent of eye lens 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0008171 O-methyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0016917 GABA receptor activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0044013 histone H2B acetyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0071617 lysophospholipid acyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0140103 catalytic activity, acting on a glycoprotein 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/1693 23/18639 0.0869565217391304 0.957343537327615 0.631143488310878 0.923707832484916 GO:0022853 active monoatomic ion transmembrane transporter activity 10/1693 118/18639 0.0847457627118644 0.933004294853184 0.638133609605005 0.923707832484916 GO:0004867 serine-type endopeptidase inhibitor activity 8/1693 95/18639 0.0842105263157895 0.927111636148848 0.641290473840485 0.923707832484916 GO:0016298 lipase activity 11/1693 130/18639 0.0846153846153846 0.931568903630333 0.6423932439301 0.923707832484916 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/1693 60/18639 0.0833333333333333 0.917454223272298 0.645928682998021 0.923707832484916 GO:0004190 aspartic-type endopeptidase activity 3/1693 36/18639 0.0833333333333333 0.917454223272298 0.647040344394451 0.923707832484916 GO:0000099 sulfur amino acid transmembrane transporter activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0005114 type II transforming growth factor beta receptor binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0005225 volume-sensitive anion channel activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0008046 axon guidance receptor activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0008432 JUN kinase binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0008503 benzodiazepine receptor activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0010854 adenylate cyclase regulator activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0015217 ADP transmembrane transporter activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0019203 carbohydrate phosphatase activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0032404 mismatch repair complex binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0045294 alpha-catenin binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0050786 RAGE receptor binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0050998 nitric-oxide synthase binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0070990 snRNP binding 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0180030 inositol phosphate kinase activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:1990948 ubiquitin ligase inhibitor activity 1/1693 11/18639 0.0909090909090909 1.00085915266069 0.649278451547489 0.923707832484916 GO:0043177 organic acid binding 16/1693 189/18639 0.0846560846560847 0.932016988721064 0.653766630451385 0.924613947562445 GO:0015149 hexose transmembrane transporter activity 2/1693 24/18639 0.0833333333333333 0.917454223272298 0.6545120499819 0.924613947562445 GO:0043998 histone H2A acetyltransferase activity 2/1693 24/18639 0.0833333333333333 0.917454223272298 0.6545120499819 0.924613947562445 GO:0050431 transforming growth factor beta binding 2/1693 24/18639 0.0833333333333333 0.917454223272298 0.6545120499819 0.924613947562445 GO:0055056 D-glucose transmembrane transporter activity 2/1693 24/18639 0.0833333333333333 0.917454223272298 0.6545120499819 0.924613947562445 GO:0015399 primary active transmembrane transporter activity 14/1693 166/18639 0.0843373493975904 0.928507888612928 0.654519250847109 0.924613947562445 GO:0005319 lipid transporter activity 15/1693 178/18639 0.0842696629213483 0.927762697691087 0.658354547298757 0.927446523320877 GO:0070001 aspartic-type peptidase activity 3/1693 37/18639 0.0810810810810811 0.892658163183857 0.665589797560227 0.927446523320877 GO:0019955 cytokine binding 12/1693 144/18639 0.0833333333333333 0.917454223272298 0.665680771930324 0.927446523320877 GO:0016209 antioxidant activity 7/1693 86/18639 0.0813953488372093 0.896118078545035 0.674670497354074 0.927446523320877 GO:0015179 L-amino acid transmembrane transporter activity 5/1693 62/18639 0.0806451612903226 0.887858925747385 0.674708320830719 0.927446523320877 GO:0004725 protein tyrosine phosphatase activity 8/1693 98/18639 0.0816326530612245 0.898730667695312 0.675924023059583 0.927446523320877 GO:0015662 P-type ion transporter activity 2/1693 25/18639 0.08 0.880756054341406 0.676681522719616 0.927446523320877 GO:0047617 fatty acyl-CoA hydrolase activity 2/1693 25/18639 0.08 0.880756054341406 0.676681522719616 0.927446523320877 GO:0140358 P-type transmembrane transporter activity 2/1693 25/18639 0.08 0.880756054341406 0.676681522719616 0.927446523320877 GO:0003720 telomerase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0004000 adenosine deaminase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0004859 phospholipase inhibitor activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0005247 voltage-gated chloride channel activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0008504 monoamine transmembrane transporter activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0015132 prostaglandin transmembrane transporter activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0016208 AMP binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0016801 hydrolase activity, acting on ether bonds 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0016803 ether hydrolase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0017166 vinculin binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0034452 dynactin binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0035197 siRNA binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0035259 nuclear glucocorticoid receptor binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0035497 cAMP response element binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0043047 single-stranded telomeric DNA binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0070410 co-SMAD binding 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:1990817 poly(A) RNA polymerase activity 1/1693 12/18639 0.0833333333333333 0.917454223272298 0.681153670654752 0.927446523320877 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1693 38/18639 0.0789473684210526 0.869167158889545 0.683417694747573 0.929478918928696 GO:0003743 translation initiation factor activity 4/1693 51/18639 0.0784313725490196 0.863486327785692 0.692439497230757 0.931081378626417 GO:0008198 ferrous iron binding 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0015145 monosaccharide transmembrane transporter activity 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0015216 purine nucleotide transmembrane transporter activity 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0016289 acyl-CoA hydrolase activity 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0030247 polysaccharide binding 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0034237 protein kinase A regulatory subunit binding 2/1693 26/18639 0.0769230769230769 0.846880821482121 0.697676807806355 0.931081378626417 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/1693 88/18639 0.0795454545454545 0.875751758578102 0.698012252701369 0.931081378626417 GO:0030159 signaling receptor complex adaptor activity 4/1693 52/18639 0.0769230769230769 0.846880821482121 0.707125777769099 0.931081378626417 GO:0002161 aminoacyl-tRNA editing activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0003964 RNA-directed DNA polymerase activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0004465 lipoprotein lipase activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0004535 poly(A)-specific ribonuclease activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0005035 death receptor activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0005542 folic acid binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0008417 fucosyltransferase activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0019855 calcium channel inhibitor activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0030955 potassium ion binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0035325 Toll-like receptor binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0039706 co-receptor binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0043560 insulin receptor substrate binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0046974 histone H3K9 methyltransferase activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0046975 histone H3K36 methyltransferase activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0051011 microtubule minus-end binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0061459 L-arginine transmembrane transporter activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0070700 BMP receptor binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0071714 icosanoid transmembrane transporter activity 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:1901338 catecholamine binding 1/1693 13/18639 0.0769230769230769 0.846880821482121 0.710133476075996 0.931081378626417 GO:0015036 disulfide oxidoreductase activity 3/1693 40/18639 0.075 0.825708800945068 0.716921146329024 0.931081378626417 GO:0015144 carbohydrate transmembrane transporter activity 3/1693 40/18639 0.075 0.825708800945068 0.716921146329024 0.931081378626417 GO:0032451 demethylase activity 3/1693 40/18639 0.075 0.825708800945068 0.716921146329024 0.931081378626417 GO:0001671 ATPase activator activity 2/1693 27/18639 0.0740740740740741 0.815514865130931 0.717528175281092 0.931081378626417 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1693 27/18639 0.0740740740740741 0.815514865130931 0.717528175281092 0.931081378626417 GO:0008320 protein transmembrane transporter activity 2/1693 27/18639 0.0740740740740741 0.815514865130931 0.717528175281092 0.931081378626417 GO:0015252 proton channel activity 2/1693 27/18639 0.0740740740740741 0.815514865130931 0.717528175281092 0.931081378626417 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 2/1693 27/18639 0.0740740740740741 0.815514865130931 0.717528175281092 0.931081378626417 GO:0016251 RNA polymerase II general transcription initiation factor activity 4/1693 53/18639 0.0754716981132075 0.83090193805793 0.721294969934261 0.931081378626417 GO:0031406 carboxylic acid binding 15/1693 187/18639 0.0802139037433155 0.883111017053549 0.730660678708713 0.931081378626417 GO:0004812 aminoacyl-tRNA ligase activity 3/1693 41/18639 0.0731707317073171 0.805569561897627 0.732610768463665 0.931081378626417 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1693 41/18639 0.0731707317073171 0.805569561897627 0.732610768463665 0.931081378626417 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/1693 41/18639 0.0731707317073171 0.805569561897627 0.732610768463665 0.931081378626417 GO:0140318 protein transporter activity 3/1693 41/18639 0.0731707317073171 0.805569561897627 0.732610768463665 0.931081378626417 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/1693 54/18639 0.0740740740740741 0.815514865130931 0.734949432993318 0.931081378626417 GO:0019789 SUMO transferase activity 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0036408 histone H3K14 acetyltransferase activity 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0045499 chemorepellent activity 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0051019 mitogen-activated protein kinase binding 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0051119 sugar transmembrane transporter activity 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0141052 histone H3 demethylase activity 2/1693 28/18639 0.0714285714285714 0.786389334233398 0.736270084355637 0.931081378626417 GO:0004705 JUN kinase activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0005344 oxygen carrier activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0005347 ATP transmembrane transporter activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0008174 mRNA methyltransferase activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0015926 glucosidase activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0019992 diacylglycerol binding 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0031404 chloride ion binding 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0032454 histone H3K9 demethylase activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0042813 Wnt receptor activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0071933 Arp2/3 complex binding 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0098847 sequence-specific single stranded DNA binding 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:1901474 azole transmembrane transporter activity 1/1693 14/18639 0.0714285714285714 0.786389334233398 0.736480733941524 0.931081378626417 GO:0009055 electron transfer activity 9/1693 116/18639 0.0775862068965517 0.854181518219036 0.737138286480998 0.931081378626417 GO:0003774 cytoskeletal motor activity 12/1693 153/18639 0.0784313725490196 0.863486327785692 0.744143709946949 0.938945728257669 GO:0004520 DNA endonuclease activity 3/1693 42/18639 0.0714285714285714 0.786389334233398 0.747606157233277 0.942327844629811 GO:0003777 microtubule motor activity 5/1693 68/18639 0.0735294117647059 0.809518432299086 0.751394978250315 0.943088240785361 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 5/1693 68/18639 0.0735294117647059 0.809518432299086 0.751394978250315 0.943088240785361 GO:0010484 histone H3 acetyltransferase activity 2/1693 29/18639 0.0689655172413793 0.759272460639143 0.753940173616183 0.943088240785361 GO:0015101 organic cation transmembrane transporter activity 6/1693 81/18639 0.0740740740740741 0.815514865130931 0.756006747091417 0.943088240785361 GO:0004497 monooxygenase activity 8/1693 106/18639 0.0754716981132075 0.83090193805793 0.757678755895321 0.943088240785361 GO:0000774 adenyl-nucleotide exchange factor activity 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0004089 carbonate dehydratase activity 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0004129 cytochrome-c oxidase activity 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0017081 chloride channel regulator activity 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0030553 cGMP binding 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0033130 acetylcholine receptor binding 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0045504 dynein heavy chain binding 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0047372 monoacylglycerol lipase activity 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0050700 CARD domain binding 1/1693 15/18639 0.0666666666666667 0.733963378617838 0.760434458367672 0.943088240785361 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 4/1693 56/18639 0.0714285714285714 0.786389334233398 0.760731759372092 0.943088240785361 GO:0008200 ion channel inhibitor activity 3/1693 43/18639 0.0697674418604651 0.768101210181458 0.761920476200005 0.943591134451188 GO:0016853 isomerase activity 14/1693 180/18639 0.0777777777777778 0.856290608387478 0.766372516287004 0.947496910113697 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0032452 histone demethylase activity 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0043995 histone H4K5 acetyltransferase activity 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0043996 histone H4K8 acetyltransferase activity 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0043997 histone H4K12 acetyltransferase activity 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0051721 protein phosphatase 2A binding 2/1693 30/18639 0.0666666666666667 0.733963378617838 0.770578399926492 0.947496910113697 GO:0016782 transferase activity, transferring sulphur-containing groups 5/1693 70/18639 0.0714285714285714 0.786389334233398 0.77373374570827 0.94825495912658 GO:0016248 channel inhibitor activity 3/1693 44/18639 0.0681818181818182 0.750644364495516 0.775568715117651 0.94825495912658 GO:0003697 single-stranded DNA binding 9/1693 121/18639 0.0743801652892562 0.818884761267836 0.780683568263838 0.94825495912658 GO:0005149 interleukin-1 receptor binding 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0016722 oxidoreductase activity, acting on metal ions 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0022841 potassium ion leak channel activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0022858 alanine transmembrane transporter activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0055102 lipase inhibitor activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0097027 ubiquitin-protein transferase activator activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1693 16/18639 0.0625 0.688090667454223 0.782211974582424 0.94825495912658 GO:0005452 solute:inorganic anion antiporter activity 2/1693 31/18639 0.0645161290322581 0.710287140597908 0.786226307374935 0.949301302992783 GO:0016411 acylglycerol O-acyltransferase activity 2/1693 31/18639 0.0645161290322581 0.710287140597908 0.786226307374935 0.949301302992783 GO:0016878 acid-thiol ligase activity 2/1693 31/18639 0.0645161290322581 0.710287140597908 0.786226307374935 0.949301302992783 GO:0140457 protein demethylase activity 2/1693 31/18639 0.0645161290322581 0.710287140597908 0.786226307374935 0.949301302992783 GO:0046915 transition metal ion transmembrane transporter activity 3/1693 45/18639 0.0666666666666667 0.733963378617838 0.788567387407595 0.950223701826152 GO:0141110 transporter inhibitor activity 3/1693 45/18639 0.0666666666666667 0.733963378617838 0.788567387407595 0.950223701826152 GO:0030246 carbohydrate binding 22/1693 280/18639 0.0785714285714286 0.865028267656738 0.792578223898915 0.950268552222956 GO:0015079 potassium ion transmembrane transporter activity 12/1693 160/18639 0.075 0.825708800945068 0.795997429828096 0.950268552222956 GO:0015078 proton transmembrane transporter activity 14/1693 185/18639 0.0756756756756757 0.8331476189716 0.799651376443021 0.950268552222956 GO:0015106 bicarbonate transmembrane transporter activity 2/1693 32/18639 0.0625 0.688090667454223 0.800926409767212 0.950268552222956 GO:0022884 macromolecule transmembrane transporter activity 2/1693 32/18639 0.0625 0.688090667454223 0.800926409767212 0.950268552222956 GO:0042910 xenobiotic transmembrane transporter activity 2/1693 32/18639 0.0625 0.688090667454223 0.800926409767212 0.950268552222956 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/1693 46/18639 0.0652173913043478 0.718007652995711 0.800934254986177 0.950268552222956 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0008429 phosphatidylethanolamine binding 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0019198 transmembrane receptor protein phosphatase activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0030548 acetylcholine receptor regulator activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0036041 long-chain fatty acid binding 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0045125 bioactive lipid receptor activity 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0046965 nuclear retinoid X receptor binding 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0070492 oligosaccharide binding 1/1693 17/18639 0.0588235294117647 0.647614745839269 0.802010885984021 0.950268552222956 GO:0005200 structural constituent of cytoskeleton 8/1693 112/18639 0.0714285714285714 0.786389334233398 0.80859860725849 0.957132929024048 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/1693 33/18639 0.0606060606060606 0.667239435107126 0.814721672088136 0.959333096881563 GO:0071889 14-3-3 protein binding 2/1693 33/18639 0.0606060606060606 0.667239435107126 0.814721672088136 0.959333096881563 GO:0016836 hydro-lyase activity 4/1693 61/18639 0.0655737704918033 0.72193119208312 0.816624396873551 0.959333096881563 GO:0046982 protein heterodimerization activity 29/1693 369/18639 0.0785907859078591 0.865241381297451 0.819810991933014 0.959333096881563 GO:0004706 JUN kinase kinase kinase activity 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0016854 racemase and epimerase activity 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0022851 GABA-gated chloride ion channel activity 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0098641 cadherin binding involved in cell-cell adhesion 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0099602 neurotransmitter receptor regulator activity 1/1693 18/18639 0.0555555555555556 0.611636148848199 0.820010862894614 0.959333096881563 GO:0032266 phosphatidylinositol-3-phosphate binding 3/1693 48/18639 0.0625 0.688090667454223 0.823848395802304 0.959840189848708 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1693 34/18639 0.0588235294117647 0.647614745839269 0.82765507806475 0.959840189848708 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1693 34/18639 0.0588235294117647 0.647614745839269 0.82765507806475 0.959840189848708 GO:0015171 amino acid transmembrane transporter activity 7/1693 102/18639 0.0686274509803922 0.755550536812481 0.829813804161836 0.959840189848708 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/1693 89/18639 0.0674157303370786 0.74221015815287 0.829862756972811 0.959840189848708 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/1693 89/18639 0.0674157303370786 0.74221015815287 0.829862756972811 0.959840189848708 GO:0060590 ATPase regulator activity 3/1693 49/18639 0.0612244897959184 0.674048000771484 0.834435314434946 0.959840189848708 GO:0004890 GABA-A receptor activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0015245 fatty acid transmembrane transporter activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0022840 leak channel activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0022842 narrow pore channel activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0031420 alkali metal ion binding 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0034987 immunoglobulin receptor binding 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0070003 threonine-type peptidase activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0097001 ceramide binding 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0141147 intracellularly calcium-gated channel activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:1990380 K48-linked deubiquitinase activity 1/1693 19/18639 0.0526315789473684 0.57944477259303 0.836375269162775 0.959840189848708 GO:0140793 histone H2AXY142 phosphatase activity 6/1693 90/18639 0.0666666666666667 0.733963378617838 0.837693602757055 0.960438431324692 GO:0010485 histone H4 acetyltransferase activity 2/1693 35/18639 0.0571428571428571 0.629111467386718 0.839769272482033 0.961903016483697 GO:0020037 heme binding 10/1693 142/18639 0.0704225352112676 0.775313428117435 0.840859263945831 0.962236859501165 GO:0048020 CCR chemokine receptor binding 3/1693 50/18639 0.06 0.660567040756054 0.844469337897218 0.965406012483412 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/1693 91/18639 0.0659340659340659 0.725897846984675 0.845230990182572 0.965406012483412 GO:0022843 voltage-gated monoatomic cation channel activity 10/1693 143/18639 0.0699300699300699 0.769891655892837 0.846893112756686 0.965875172103358 GO:0001614 purinergic nucleotide receptor activity 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0005326 neurotransmitter transmembrane transporter activity 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0010851 cyclase regulator activity 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0016502 nucleotide receptor activity 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0140664 ATP-dependent DNA damage sensor activity 1/1693 20/18639 0.05 0.550472533963379 0.85125264130603 0.965875172103358 GO:0052689 carboxylic ester hydrolase activity 6/1693 92/18639 0.0652173913043478 0.718007652995711 0.852481190751887 0.966230328207831 GO:0120013 lipid transfer activity 4/1693 65/18639 0.0615384615384615 0.677504657185697 0.853198563525821 0.966230328207831 GO:0016830 carbon-carbon lyase activity 3/1693 51/18639 0.0588235294117647 0.647614745839269 0.853971202938872 0.966230328207831 GO:0016835 carbon-oxygen lyase activity 5/1693 79/18639 0.0632911392405063 0.696800675903011 0.855557798069388 0.967117398380499 GO:0000049 tRNA binding 5/1693 80/18639 0.0625 0.688090667454223 0.862907587250976 0.972976218891527 GO:0001846 opsonin binding 1/1693 21/18639 0.0476190476190476 0.524259556155599 0.864778033554212 0.972976218891527 GO:0015174 basic amino acid transmembrane transporter activity 1/1693 21/18639 0.0476190476190476 0.524259556155599 0.864778033554212 0.972976218891527 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/1693 21/18639 0.0476190476190476 0.524259556155599 0.864778033554212 0.972976218891527 GO:0070182 DNA polymerase binding 1/1693 21/18639 0.0476190476190476 0.524259556155599 0.864778033554212 0.972976218891527 GO:0005244 voltage-gated monoatomic ion channel activity 12/1693 173/18639 0.069364161849711 0.763661318793126 0.871287807043702 0.975667835266446 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1693 53/18639 0.0566037735849057 0.623176453543448 0.871461745328125 0.975667835266446 GO:0042162 telomeric DNA binding 2/1693 38/18639 0.0526315789473684 0.57944477259303 0.871612182472422 0.975667835266446 GO:0003823 antigen binding 12/1693 174/18639 0.0689655172413793 0.759272460639143 0.876021171637918 0.975667835266446 GO:0140223 general transcription initiation factor activity 4/1693 68/18639 0.0588235294117647 0.647614745839269 0.876389870973533 0.975667835266446 GO:0005243 gap junction channel activity 1/1693 22/18639 0.0454545454545455 0.500429576330344 0.877074240944518 0.975667835266446 GO:0008649 rRNA methyltransferase activity 1/1693 22/18639 0.0454545454545455 0.500429576330344 0.877074240944518 0.975667835266446 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1693 22/18639 0.0454545454545455 0.500429576330344 0.877074240944518 0.975667835266446 GO:0033691 sialic acid binding 1/1693 22/18639 0.0454545454545455 0.500429576330344 0.877074240944518 0.975667835266446 GO:0022804 active transmembrane transporter activity 35/1693 457/18639 0.0765864332603939 0.843174559681324 0.877758040791734 0.975667835266446 GO:0005126 cytokine receptor binding 20/1693 275/18639 0.0727272727272727 0.800687322128551 0.879039126965356 0.975667835266446 GO:0015485 cholesterol binding 3/1693 54/18639 0.0555555555555556 0.611636148848199 0.87949188134782 0.975667835266446 GO:0022832 voltage-gated channel activity 12/1693 175/18639 0.0685714285714286 0.754933760864062 0.880613974036348 0.975667835266446 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1693 39/18639 0.0512820512820513 0.564587214321414 0.880860068847107 0.975667835266446 GO:0098960 postsynaptic neurotransmitter receptor activity 4/1693 69/18639 0.0579710144927536 0.638229024885077 0.883382291012894 0.975667835266446 GO:0005267 potassium channel activity 8/1693 124/18639 0.0645161290322581 0.710287140597908 0.885445488686883 0.975667835266446 GO:0008374 O-acyltransferase activity 3/1693 55/18639 0.0545454545454545 0.600515491596413 0.887072575036742 0.975667835266446 GO:0004602 glutathione peroxidase activity 1/1693 23/18639 0.0434782608695652 0.478671768663807 0.888252911518774 0.975667835266446 GO:0099186 structural constituent of postsynapse 1/1693 23/18639 0.0434782608695652 0.478671768663807 0.888252911518774 0.975667835266446 GO:0140102 catalytic activity, acting on a rRNA 1/1693 23/18639 0.0434782608695652 0.478671768663807 0.888252911518774 0.975667835266446 GO:0140662 ATP-dependent protein folding chaperone 2/1693 40/18639 0.05 0.550472533963379 0.889488433190164 0.975667835266446 GO:0008028 monocarboxylic acid transmembrane transporter activity 4/1693 70/18639 0.0571428571428571 0.629111467386718 0.890027657394992 0.975667835266446 GO:0046873 metal ion transmembrane transporter activity 34/1693 450/18639 0.0755555555555556 0.83182516243355 0.891974419262872 0.975667835266446 GO:0046906 tetrapyrrole binding 10/1693 152/18639 0.0657894736842105 0.724305965741288 0.893418152840648 0.975667835266446 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 16/1693 229/18639 0.0698689956331878 0.769219261433542 0.893568601724467 0.975667835266446 GO:0170055 lipid transmembrane transporter activity 3/1693 56/18639 0.0535714285714286 0.589792000675048 0.894223941961156 0.975667835266446 GO:0001530 lipopolysaccharide binding 2/1693 41/18639 0.0487804878048781 0.537046374598418 0.897533441637677 0.975667835266446 GO:0004622 lysophospholipase activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0004806 triacylglycerol lipase activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0005315 phosphate transmembrane transporter activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0015295 solute:proton symporter activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0030215 semaphorin receptor binding 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0050699 WW domain binding 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0070300 phosphatidic acid binding 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0140612 DNA damage sensor activity 1/1693 24/18639 0.0416666666666667 0.458727111636149 0.898415557672551 0.975667835266446 GO:0016874 ligase activity 11/1693 167/18639 0.0658682634730539 0.725173398035589 0.901571357313037 0.975667835266446 GO:0042379 chemokine receptor binding 4/1693 72/18639 0.0555555555555556 0.611636148848199 0.902329480861469 0.975667835266446 GO:0004402 histone acetyltransferase activity 2/1693 42/18639 0.0476190476190476 0.524259556155599 0.905029805857897 0.975667835266446 GO:0001848 complement binding 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0004709 MAP kinase kinase kinase activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0005251 delayed rectifier potassium channel activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0005537 D-mannose binding 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0008483 transaminase activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0015645 fatty acid ligase activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0120020 cholesterol transfer activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0120515 fatty acid-CoA ligase activity 1/1693 25/18639 0.04 0.440378027170703 0.90765447579559 0.975667835266446 GO:0016798 hydrolase activity, acting on glycosyl bonds 8/1693 130/18639 0.0615384615384615 0.677504657185697 0.91303879137967 0.978351182907257 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/1693 130/18639 0.0615384615384615 0.677504657185697 0.91303879137967 0.978351182907257 GO:0003678 DNA helicase activity 4/1693 74/18639 0.0540540540540541 0.595105442122572 0.91339840727856 0.978351182907257 GO:0003684 damaged DNA binding 4/1693 74/18639 0.0540540540540541 0.595105442122572 0.91339840727856 0.978351182907257 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1693 26/18639 0.0384615384615385 0.423440410741061 0.91605358251516 0.978585608981177 GO:0008157 protein phosphatase 1 binding 1/1693 26/18639 0.0384615384615385 0.423440410741061 0.91605358251516 0.978585608981177 GO:0019865 immunoglobulin binding 1/1693 26/18639 0.0384615384615385 0.423440410741061 0.91605358251516 0.978585608981177 GO:0015291 secondary active transmembrane transporter activity 20/1693 287/18639 0.0696864111498258 0.767209106569169 0.91736565960853 0.97911923811185 GO:0019205 nucleobase-containing compound kinase activity 2/1693 44/18639 0.0454545454545455 0.500429576330344 0.918507988465675 0.979470908054105 GO:0004364 glutathione transferase activity 1/1693 27/18639 0.037037037037037 0.407757432565466 0.923689175101085 0.983255703177392 GO:0016405 CoA-ligase activity 1/1693 27/18639 0.037037037037037 0.407757432565466 0.923689175101085 0.983255703177392 GO:0008009 chemokine activity 2/1693 45/18639 0.0444444444444444 0.489308919078559 0.924551737352098 0.983305245815779 GO:0005261 monoatomic cation channel activity 24/1693 341/18639 0.0703812316715543 0.774858698834081 0.926666481086864 0.983461585622797 GO:0046943 carboxylic acid transmembrane transporter activity 12/1693 188/18639 0.0638297872340425 0.702730894421334 0.928689336402334 0.983461585622797 GO:0097718 disordered domain specific binding 1/1693 28/18639 0.0357142857142857 0.393194667116699 0.930630622906472 0.983461585622797 GO:0005342 organic acid transmembrane transporter activity 12/1693 189/18639 0.0634920634920635 0.699012741540798 0.931585398581003 0.983461585622797 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1693 63/18639 0.0476190476190476 0.524259556155599 0.9338597826068 0.983461585622797 GO:0022835 transmitter-gated channel activity 3/1693 63/18639 0.0476190476190476 0.524259556155599 0.9338597826068 0.983461585622797 GO:0008528 G protein-coupled peptide receptor activity 7/1693 122/18639 0.0573770491803279 0.63168979307273 0.934510149439343 0.983461585622797 GO:0061733 protein-lysine-acetyltransferase activity 2/1693 47/18639 0.0425531914893617 0.468487262947556 0.935392164255074 0.983461585622797 GO:0061749 forked DNA-dependent helicase activity 2/1693 47/18639 0.0425531914893617 0.468487262947556 0.935392164255074 0.983461585622797 GO:0099095 ligand-gated monoatomic anion channel activity 2/1693 47/18639 0.0425531914893617 0.468487262947556 0.935392164255074 0.983461585622797 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/1693 47/18639 0.0425531914893617 0.468487262947556 0.935392164255074 0.983461585622797 GO:0019842 vitamin binding 9/1693 150/18639 0.06 0.660567040756054 0.935515677109952 0.983461585622797 GO:0016410 N-acyltransferase activity 5/1693 94/18639 0.0531914893617021 0.585609078684445 0.936770788981955 0.983461585622797 GO:0003785 actin monomer binding 1/1693 29/18639 0.0344827586206897 0.379636230319571 0.936940996095411 0.983461585622797 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/1693 29/18639 0.0344827586206897 0.379636230319571 0.936940996095411 0.983461585622797 GO:0009378 four-way junction helicase activity 2/1693 48/18639 0.0416666666666667 0.458727111636149 0.940241893318238 0.98349954986847 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1693 48/18639 0.0416666666666667 0.458727111636149 0.940241893318238 0.98349954986847 GO:0036121 double-stranded DNA helicase activity 2/1693 48/18639 0.0416666666666667 0.458727111636149 0.940241893318238 0.98349954986847 GO:0043138 3'-5' DNA helicase activity 2/1693 48/18639 0.0416666666666667 0.458727111636149 0.940241893318238 0.98349954986847 GO:0016769 transferase activity, transferring nitrogenous groups 1/1693 30/18639 0.0333333333333333 0.366981689308919 0.942677637342615 0.984338434140253 GO:0098918 structural constituent of synapse 1/1693 30/18639 0.0333333333333333 0.366981689308919 0.942677637342615 0.984338434140253 GO:0016407 acetyltransferase activity 5/1693 96/18639 0.0520833333333333 0.573408889545186 0.9437215530282 0.984575299912537 GO:0047499 calcium-independent phospholipase A2 activity 1/1693 31/18639 0.032258064516129 0.355143570298954 0.947892681674872 0.987916061509606 GO:0008173 RNA methyltransferase activity 3/1693 67/18639 0.0447761194029851 0.49296047817616 0.949837966307795 0.987916061509606 GO:0005249 voltage-gated potassium channel activity 5/1693 98/18639 0.0510204081632653 0.56170666730957 0.949974780540077 0.987916061509606 GO:0005254 chloride channel activity 4/1693 83/18639 0.0481927710843374 0.530575936350244 0.950530528511491 0.987916061509606 GO:0001653 peptide receptor activity 7/1693 128/18639 0.0546875 0.602079334022445 0.952091549036812 0.987916061509606 GO:0120015 sterol transfer activity 1/1693 32/18639 0.03125 0.344045333727112 0.952633529155764 0.987916061509606 GO:0016597 amino acid binding 2/1693 51/18639 0.0392156862745098 0.431743163892846 0.952797984449235 0.987916061509606 GO:0008080 N-acetyltransferase activity 3/1693 69/18639 0.0434782608695652 0.478671768663807 0.956402677826839 0.987916061509606 GO:0019239 deaminase activity 1/1693 33/18639 0.0303030303030303 0.333619717553563 0.956943274689127 0.987916061509606 GO:0019956 chemokine binding 1/1693 33/18639 0.0303030303030303 0.333619717553563 0.956943274689127 0.987916061509606 GO:0030296 protein tyrosine kinase activator activity 1/1693 33/18639 0.0303030303030303 0.333619717553563 0.956943274689127 0.987916061509606 GO:0016829 lyase activity 12/1693 200/18639 0.06 0.660567040756054 0.9573326262009 0.987916061509606 GO:0034212 protein N-acetyltransferase activity 2/1693 53/18639 0.0377358490566038 0.415450969028965 0.959722010296808 0.987916061509606 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1693 53/18639 0.0377358490566038 0.415450969028965 0.959722010296808 0.987916061509606 GO:0022834 ligand-gated channel activity 11/1693 188/18639 0.0585106382978723 0.64416998655289 0.960458208732071 0.987916061509606 GO:0015020 glucuronosyltransferase activity 1/1693 34/18639 0.0294117647058824 0.323807372919635 0.96086109882926 0.987916061509606 GO:0019825 oxygen binding 1/1693 34/18639 0.0294117647058824 0.323807372919635 0.96086109882926 0.987916061509606 GO:0005253 monoatomic anion channel activity 5/1693 103/18639 0.0485436893203883 0.534439353362503 0.962940452824864 0.989209928093744 GO:0004623 phospholipase A2 activity 1/1693 35/18639 0.0285714285714286 0.314555733693359 0.96442262313359 0.989888637884136 GO:0008509 monoatomic anion transmembrane transporter activity 8/1693 149/18639 0.0536912751677852 0.591111445866715 0.966203483707186 0.990158717689294 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/1693 73/18639 0.0410958904109589 0.452443178600037 0.96718874890575 0.990158717689294 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/1693 36/18639 0.0277777777777778 0.305818074424099 0.967660233273067 0.990158717689294 GO:0099094 ligand-gated monoatomic cation channel activity 7/1693 136/18639 0.0514705882352941 0.56666290260936 0.968929271842529 0.990158717689294 GO:0015103 inorganic anion transmembrane transporter activity 9/1693 165/18639 0.0545454545454545 0.600515491596413 0.968977213289373 0.990158717689294 GO:0003730 mRNA 3'-UTR binding 16/1693 262/18639 0.0610687022900763 0.67233286590947 0.969616005704039 0.990158717689294 GO:0022836 gated channel activity 20/1693 318/18639 0.0628930817610063 0.692418281714942 0.97273441739092 0.990541356869483 GO:0005216 monoatomic ion channel activity 30/1693 448/18639 0.0669642857142857 0.737240000843811 0.972885783402055 0.990541356869483 GO:0017116 single-stranded DNA helicase activity 2/1693 58/18639 0.0344827586206897 0.379636230319571 0.973026491373456 0.990541356869483 GO:0000146 microfilament motor activity 1/1693 38/18639 0.0263157894736842 0.289722386296515 0.973278810401218 0.990541356869483 GO:0000217 DNA secondary structure binding 1/1693 39/18639 0.0256410256410256 0.282293607160707 0.975710882547379 0.991342001239116 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/1693 39/18639 0.0256410256410256 0.282293607160707 0.975710882547379 0.991342001239116 GO:0015276 ligand-gated monoatomic ion channel activity 10/1693 186/18639 0.0537634408602151 0.591905950498257 0.977889187301526 0.992697832278796 GO:0004896 cytokine receptor activity 4/1693 96/18639 0.0416666666666667 0.458727111636149 0.978962904420288 0.992697832278796 GO:0008227 G protein-coupled amine receptor activity 1/1693 41/18639 0.024390243902439 0.268523187299209 0.979931421405792 0.992697832278796 GO:0030594 neurotransmitter receptor activity 4/1693 97/18639 0.0412371134020619 0.453997966155364 0.980340597852089 0.992697832278796 GO:0015293 symporter activity 7/1693 146/18639 0.0479452054794521 0.527850375033377 0.982340215778882 0.993887455930775 GO:0015108 chloride transmembrane transporter activity 5/1693 121/18639 0.0413223140495868 0.454935978482131 0.988120431182558 0.998830450424532 GO:0008188 neuropeptide receptor activity 1/1693 48/18639 0.0208333333333333 0.229363555818074 0.989712496105304 0.998830450424532 GO:0038187 pattern recognition receptor activity 1/1693 48/18639 0.0208333333333333 0.229363555818074 0.989712496105304 0.998830450424532 GO:0005125 cytokine activity 12/1693 234/18639 0.0512820512820513 0.564587214321414 0.99160658549915 0.999904548557721 GO:0140375 immune receptor activity 6/1693 156/18639 0.0384615384615385 0.423440410741061 0.996458235238095 0.999999998923355 GO:0015081 sodium ion transmembrane transporter activity 6/1693 164/18639 0.0365853658536585 0.402784780948814 0.997920628497935 0.999999998923355 GO:0015294 solute:monoatomic cation symporter activity 3/1693 116/18639 0.0258620689655172 0.284727172739679 0.998767257132418 0.999999998923355 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/1693 122/18639 0.0245901639344262 0.27072419703117 0.999238493796458 0.999999998923355 GO:0015370 solute:sodium symporter activity 1/1693 79/18639 0.0126582278481013 0.139360135180602 0.999468222884111 0.999999998923355 GO:0005179 hormone activity 3/1693 132/18639 0.0227272727272727 0.250214788165172 0.999661975030281 0.999999998923355 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3/1693 132/18639 0.0227272727272727 0.250214788165172 0.999661975030281 0.999999998923355 GO:0030527 structural constituent of chromatin 1/1693 98/18639 0.0102040816326531 0.112341333461914 0.999913689163453 0.999999998923355 GO:0045182 translation regulator activity 7/1693 356/18639 0.0196629213483146 0.216477962794587 0.999999995136419 0.999999998923355 GO:0030371 translation repressor activity 5/1693 329/18639 0.0151975683890578 0.167316879624127 0.999999998923355 0.999999998923355