category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	62/269	238/9376	9.07987879166537	ISG15/RPS27/PIK3R1/RPL38/STAT1/OAS2/MX1/RPS21/RPS29/RPL39/RPS11/EIF2AK2/RPS17/OAS1/RPS28/RPL36/RPL23/IRF9/RPS14/RPL34/OAS3/RPL37A/RPL37/RPLP1/RPLP0/MX2/RPL18/RPS2/FAU/RPL29/RPL30/RPS20/RPL23A/RPL35A/RPS23/RPLP2/RPL27/RPS18/RPL9/RPS27L/RPL24/RPS15A/ADAR/RPL21/RPL7/IFIH1/RPL31/RPL28/RPS9/RPL32/RPL18A/NRP1/RPS13/RPL35/RPS16/CFD/C1S/RPS7/RPS19/C3/UBA52/RPS25	21.6991068041332
Genetic Information Processing	Translation	hsa03010	Ribosome	46/269	222/9376	7.22221105864228	RPS27/RPL38/RPS21/RPS29/RPL39/RPS11/RPS17/RPS28/RPL36/RPL23/RPS14/RPL34/RPL37A/RPL37/RPLP1/RPLP0/RPL18/RPS2/FAU/RPL29/RPL30/RPS20/RPL23A/RPL35A/RPS23/RPLP2/RPL27/RPS18/RPL9/RPS27L/RPL24/RPS15A/RPL21/RPL7/RPL31/RPL28/RPS9/RPL32/RPL18A/RPS13/RPL35/RPS16/RPS7/RPS19/UBA52/RPS25	16.1246345847822
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	22/269	180/9376	4.26005782734407	BST2/B2M/PIK3R1/STAT1/OAS2/EIF2AK2/OAS1/HLA-A/HLA-B/IRF9/OAS3/PPP1CB/SRSF7/HLA-C/IFIH1/CCL5/SP100/HLA-F/BIRC3/CD74/C3/HLA-DMB	7.58990228850776
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/269	173/9376	3.62653372585255	PIK3R1/STAT1/OAS2/MX1/EIF2AK2/OAS1/IRF9/OAS3/MX2/RSAD2/ACTG1/ACTB/ADAR/IFIH1/CCL5/RAB11A/HLA-DMB/CDK6	5.99260196250679
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/269	156/9376	3.79830330759699	PIK3R1/STAT1/OAS2/MX1/EIF2AK2/IFIT1/OAS1/IRF9/YWHAZ/OAS3/MX2/RSAD2/PIAS1/PPP2R1A/CDK6/SOS1/CTNNB1	6.05711381650093
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/269	82/9376	4.25061202284885	B2M/HLA-A/HLA-B/PSME1/HLA-C/CTSL/HLA-F/CD74/HLA-DMB/HSP90AA1	5.0809490427529
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	13/269	138/9376	3.28344377996875	ATP5F1E/ATP6V1G1/MT-ND3/PPA1/COX7C/ATP5MG/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/UQCRQ	4.64424366736368
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/269	157/9376	3.10809082944617	SNAI2/CTNNA2/YWHAZ/PPP1CB/ACTG1/CTNNA3/ACTB/MOB1A/BIRC3/ID1/BMP8A/PPP2R1A/LIMD1/CTNNB1	4.57795318975084
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/269	205/9376	2.72039169462327	ISG15/B2M/PIK3R1/STAT1/OAS2/EIF2AK2/OAS1/HLA-A/HLA-B/IRF9/OAS3/HLA-C/HLA-F/HLA-DMB/CDK6/CD247	4.2802588214089
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/269	227/9376	2.61028773561731	B2M/PIK3R1/CCL4/HLA-A/HLA-B/GNB2/CALM2/HLA-C/GNAS/PLCB1/CCL3/CCL5/HLA-F/CCL4L2/CDK6/SOS1/CTNNB1	4.22088684849373
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/269	93/9376	3.74785146100652	SNAI2/CTNNA2/CDC42/ACTG1/CTNNA3/ACTB/MYL12B/HEG1/BAIAP2/CTNNB1	4.57682873666808
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/269	78/9376	4.02173291392622	PIK3R1/CTNNA2/CDC42/ACTG1/CTNNA3/ACTB/SEPTIN2/ARHGAP10/CTNNB1	4.60556287281469
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	15/269	196/9376	2.667475912298	PIK3R1/STAT1/EIF2AK2/HLA-A/HLA-B/IRF9/UBB/GNB2/CALM2/HLA-C/HLA-F/C3/UBA52/CDK6/CTNNB1	4.0545286538473
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/269	136/9376	3.07544281653182	PIK3R1/STAT1/OAS2/MX1/EIF2AK2/OAS1/IRF9/OAS3/MX2/ADAR/IFIH1/CDK6	4.19004175156721
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/269	51/9376	4.78402215904949	ACTG1/ATP6V1G1/ACTB/GNAS/SEC61B/SLC12A2/KDELR2	4.65680924713412
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/269	333/9376	2.19806423523896	ISG15/PIK3R1/STAT1/MX1/EIF2AK2/HLA-A/COL1A2/HLA-B/IRF9/CDC42/MX2/ATP6V1G1/HLA-C/GNAS/COL6A1/HLA-F/COL6A3/PPP2R1A/CDK6/SOS1/CTNNB1	3.82578063884609
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/269	39/9376	5.36231055190163	HLA-A/HLA-B/HLA-C/HLA-F/GZMB/HLA-DMB	4.69158202501989
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	15/269	205/9376	2.55036721370931	PIK3R1/COL1A2/ATP5F1E/PPP1CB/COL3A1/MT-ND3/PLCB1/COX7C/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/UQCRQ	3.85724539570948
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/269	70/9376	3.98343069569835	HLA-A/HLA-B/ACTG1/ACTB/HLA-C/HLA-F/HLA-DMB/EIF4G2	4.30583674468863
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/269	235/9376	2.37310764850115	ATP5F1E/ACTG1/MT-ND3/ACTB/GNAS/COX7C/ATP5MG/COX7B/UQCRB/COX7A2/BMP8A/ATP5PF/COX6C/NDUFB1/UQCRQ/SOS1	3.66366514564535
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/269	214/9376	2.44310877948789	BST2/B2M/PIK3R1/HLA-A/HLA-B/GNB2/CALM2/HLA-C/SKP1/RBX1/HLA-F/ELOB/PAK3/CD247/CFL1	3.67015935804672
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/269	44/9376	4.75295708009463	HLA-A/HLA-B/HLA-C/HLA-F/GZMB/HLA-DMB	4.28831501656071
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/269	155/9376	2.69845305192469	TUBB/HLA-A/HLA-B/ACTG1/ATP6V1G1/ACTB/HLA-C/CTSL/SEC61B/HLA-F/C3/HLA-DMB	3.66441367116908
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/269	45/9376	4.64733581164808	HLA-A/HLA-B/HLA-C/HLA-F/GZMB/HLA-DMB	4.21494607663057
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/269	248/9376	2.24871087660391	TUBB/DYNLL1/CDC42/ACTG1/ACTB/SKP1/RHOB/PFN1/MYL12B/PTPRC/TXN/BIRC3/PAK3/HSP90AA1/RHOH/CTNNB1	3.4251060995006
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/269	203/9376	2.40379438533521	PIK3R1/COL1A2/PPP1CB/CDC42/ACTG1/ACTB/MYL12B/COL6A1/BIRC3/PIP5K1B/COL6A3/PAK3/SOS1/CTNNB1	3.47512101854114
Organismal Systems	Immune system	hsa04611	Platelet activation	10/269	126/9376	2.76627131645719	PIK3R1/COL1A2/PPP1CB/APBB1IP/ACTG1/COL3A1/ACTB/GNAS/PLCB1/MYL12B	3.43040923092337
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/269	193/9376	2.34774736598802	PIK3R1/STAT1/CCL4/CDC42/GNB2/PLCB1/CCL3/CCL5/CXCL13/XCL1/XCL2/CCL4L2/SOS1	3.25138923864614
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/269	54/9376	3.87277984304007	HLA-A/HLA-B/HLA-C/HLA-F/GZMB/HLA-DMB	3.63846989105167
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/269	268/9376	2.08089663208123	TUBB/ATP5F1E/UBB/CALM2/MT-ND3/GNAS/TXN/COX7C/COX7B/UQCRB/COX7A2/UBA52/ATP5PF/COX6C/NDUFB1/UQCRQ	3.08541907120213
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/269	116/9376	2.70426868350212	PIK3R1/CTNNA2/CDC42/ACTG1/CTNNA3/ACTB/MYL12B/RHOH/CTNNB1	3.17421014211489
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/269	205/9376	2.2103182518814	PIK3R1/EIF2AK2/HLA-A/HLA-B/IRF9/YWHAZ/CDC42/HNRNPK/HLA-C/SP100/HLA-F/C3/CDK6	3.01121854431064
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/269	139/9376	2.50755529405472	PIK3R1/FKBP5/CALM2/NCOA2/GREB1/GNAS/PLCB1/KRT18/HSP90AA1/SOS1	3.07743783168739
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/269	232/9376	2.10332008716831	PIK3R1/TMSB4X/PPP1CB/CDC42/ACTG1/FGF7/ACTB/PFN1/MYL12B/PIP5K1B/PAK3/BAIAP2/CFL1/SOS1	2.92449927967341
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/269	98/9376	2.84530763978454	PIK3R1/MARCKS/CDC42/PTPRC/PLPP3/PIP5K1B/MARCKSL1/CFL1	3.15594004021568
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/269	187/9376	2.23668568475041	STAT1/OAS2/OAS1/TXNIP/IRF9/OAS3/GABARAP/PLCB1/TXN/CCL5/BIRC3/HSP90AA1	2.93575710800974
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/269	142/9376	2.45457877375779	PIK3R1/CALM2/SUMO2/ACTG1/GSTT2B/ACTB/TXN/CTSL/HSP90AA1/CTNNB1	3.00165374416288
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/269	61/9376	3.42836248400268	FTL/MT1G/FTH1/MT1E/MT1F/MT2A	3.27010059458435
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/269	212/9376	2.13733604545136	PIK3R1/CDC42/APBB1IP/CALM2/ACTG1/FGF7/ACTB/GNAS/PFN1/PLCB1/ID1/FYB1/CTNNB1	2.878646281716
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/269	103/9376	2.70718590969791	PIK3R1/GNAS/PLCB1/CCL3/CCL5/C3/PPP2R1A/CD247	2.99408006730032
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/269	17/9376	6.15088563306364	PCDH9/PCDH7/PCDH20	3.65313527327261
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/269	68/9376	3.07544281653182	ADH5/ALDH1A3/ALDH1A2/CYP26A1/UGT2B7/ADH4	2.95196463981997
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/269	227/9376	1.9961023860603	PIK3R1/ATP5F1E/MT-ND3/GSTT2B/COX7C/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/UQCRQ/SOS1	2.61098396769652
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/269	253/9376	1.92873620641521	PIK3R1/UBB/CDC42/ACTG1/ACTB/SKP1/PFN1/PLCB1/MYL12B/RBX1/CCL5/SEPTIN2/C3/UBA52	2.57369992414876
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	12/269	204/9376	2.05029521102121	PIK3R1/COL1A2/PPP1CB/CDC42/ACTG1/ACTB/CTSL/HOXD10/ERBB4/LUM/SOS1/CTNNB1	2.60656497864011
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/269	157/9376	2.22006487817583	PIK3R1/ZFP36L1/HLA-A/HLA-B/PPP1CB/CALM2/HLA-C/HLA-F/CDK6/IGFBP3	2.64950628442106
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/269	70/9376	2.98757302177377	PIK3R1/CDC42/RBX1/ELOB/PAK3/SOS1	2.86856502557437
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	18/269	368/9376	1.70486503959916	TUBB/ATP5F1E/SRSF7/ACTG1/MT-ND3/ACTB/PFN1/COX7C/OPTN/COX7B/UQCRB/COX7A2/ERBB4/ATP5PF/COX6C/NDUFB1/GRIA1/UQCRQ	2.37077206434368
NA	NA	hsa04519	Cadherin signaling	19/269	404/9376	1.63922117118775	CTNNA2/LHFPL3/YWHAZ/PPP1CB/CDC42/ACTG1/GJA1/GABRA2/KRT8/CTNNA3/PCDH9/ACTB/PCDH7/MOB1A/PCDH20/KRT18/GABRP/LIMD1/CTNNB1	2.25720659506953
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/269	100/9376	2.43985130111524	CCL4/CCL3/CCL5/CXCL13/XCL1/XCL2/CCL4L2	2.48777662620984
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/269	59/9376	2.95381513452208	PIK3R1/CTNNA2/CTNNA3/SOS1/CTNNB1	2.58729254638955
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/269	103/9376	2.36878767098567	PIK3R1/COL1A2/COL3A1/HSPB1/GNAS/PLCB1/PRDX1	2.40059378347952
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/269	42/9376	3.31952557974863	PCBP1/FTL/FTH1/PCBP2	2.58919060876395
NA	NA	hsa04518	Integrin signaling	9/269	154/9376	2.03698160575484	PIK3R1/COL1A2/CDC42/ACTG1/ACTB/COL6A1/C3/COL6A3/CTNNB1	2.22993890315541
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/269	86/9376	2.43174548283911	CTNNA2/ACTG1/GJA1/CTNNA3/ACTB/CTNNB1	2.29235196843691
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/269	157/9376	1.99805839035825	PIK3R1/CDC42/COX7C/COX7B/UQCRB/COX7A2/COX6C/NDUFB1/UQCRQ	2.16739455808861
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/269	109/9376	2.23839568909655	PIK3R1/STAT1/CCL4/IRF9/CCL3/CCL5/CCL4L2	2.23499836065624
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/269	133/9376	2.09654247142019	PIK3R1/HLA-A/HLA-B/HLA-C/HCST/GZMB/CD247/SOS1	2.18886466953228
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/269	87/9376	2.40379438533521	COX7C/COX7B/UQCRB/COX7A2/COX6C/UQCRQ	2.26075112612245
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/269	89/9376	2.34977653397937	PLCL1/GNB2/GABRA2/GABARAP/GLUL/GABRP	2.19883815340955
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/269	275/9376	1.64769178776614	PIK3R1/TUBB/ATP5F1E/MT-ND3/CCL5/COX7C/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/UQCRQ	1.8735456966936
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/269	388/9376	1.52715287625034	APOE/PIK3R1/EIF2AK2/TUBB/ATP5F1E/CALM2/MT-ND3/PLCB1/COX7C/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/UQCRQ/CTNNB1	1.82261534046757
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/269	97/9376	2.15598053117694	GNB2/CALM2/GNAS/PLCB1/RASD1/GRIA1	1.96679868622072
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/269	308/9376	1.58431902669821	TUBB/ATP5F1E/TGM2/MT-ND3/PLCB1/COX7C/COX7B/UQCRB/COX7A2/ATP5PF/COX6C/NDUFB1/GRIA1/UQCRQ	1.79202366502106
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/269	122/9376	1.99987811566823	PIK3R1/CDC42/PTPRC/PAK3/PPP2R1A/CD247/SOS1	1.91045292472206
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/269	122/9376	1.99987811566823	PIK3R1/STAT1/NCOA2/ACTG1/ACTB/PLCB1/CTNNB1	1.91045292472206
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/269	52/9376	2.68115527595082	APOE/LIPG/APOC1/ABCA1	2.08921183411487
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/269	76/9376	2.29309332811583	CALM2/ACTG1/ACTB/GNAS/PLCB1	1.9452225822759
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/269	101/9376	2.07059516360558	PIK3R1/STAT1/COL1A2/CDC42/COL3A1/PLCB1	1.85910155787143
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/269	102/9376	2.05029521102121	SCTR/GNAS/PLCB1/PLA2G2A/SLC12A2/RAB11A	1.83295598057889
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/269	78/9376	2.23429606329235	SERPING1/CALM2/C1S/C3/CFL1	1.88124770953842
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/269	78/9376	2.23429606329235	STAT1/EEF1A1/C3/MARCKSL1/HLA-DMB	1.88124770953842
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/269	130/9376	1.87680869316557	PIK3R1/COL1A2/GNB2/COL3A1/GNAS/PLCB1/SOS1	1.73010988909934
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/269	133/9376	1.83447466249266	PPP1CB/GNB2/CALM2/GNAS/PLCB1/PPP2R1A/GRIA1	1.6657376745147
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/269	37/9376	2.82608258816437	MIF/ADH5/ADH4	1.9126926972199
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/269	83/9376	2.09969991490124	PCBP1/CCL4/ADAR/CCL5/CCL4L2	1.72945544884751
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/269	134/9376	1.82078455307108	PPP1CB/EDNRA/CALCRL/CALM2/GNAS/PLCB1/PLA2G2A	1.644647016565
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/269	60/9376	2.32366790582404	GNAS/PLCB1/PPP2R1A/GRIA1	1.76772227337469
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/269	138/9376	1.76800818921394	PIK3R1/CDC42/ACTG1/ACTB/PIP5K1B/FYB1/BAIAP2	1.56203415233158
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/269	88/9376	1.98039878337276	SERPING1/CFD/C1S/C3/SERPINA5	1.58802416300573
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/269	168/9376	1.65976278987431	STAT1/EIF2AK2/FTL/IRF9/FTH1/GLUL/BIRC3/HSP90AA1	1.48297528591496
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/269	89/9376	1.95814711164947	TUBB/GJA1/GNAS/PLCB1/SOS1	1.56085868485415
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/269	41/9376	2.55036721370931	GABRA2/GABRP/GRIA1	1.7097926771697
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/269	142/9376	1.71820514163045	UBB/PIAS1/SKP1/RBX1/BIRC3/ELOB/UBA52	1.48208071734935
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/269	21/9376	3.31952557974863	ENPP3/BCAT1	1.82877816455983
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/269	43/9376	2.43174548283911	PLA2G2A/ABCA1/PLPP3	1.61719923184609
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/269	67/9376	2.08089663208123	PPP1CB/CALM2/PLCB1/GRIA1	1.52596354933067
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/269	93/9376	1.87392573050326	CDC42/CALM2/GNAS/PLCB1/SOS1	1.45561303215999
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/269	44/9376	2.37647854004731	DYNLL1/GNAS/RAB11A	1.57283269360214
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/269	69/9376	2.02058078767308	EDNRA/CALM2/GNAS/PLCB1	1.46231584839907
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/269	69/9376	2.02058078767308	PPP1CB/CALM2/GNAS/GRIA1	1.46231584839907
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/269	149/9376	1.63748409470822	PIK3R1/GNAS/PLCB1/DGKB/PLPP3/PIP5K1B/SOS1	1.34805104486224
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/269	149/9376	1.63748409470822	GNB2/GABRA2/MT-ND3/PLCB1/GABRP/NDUFB1/GRIA1	1.34805104486224
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/269	95/9376	1.83447466249266	ATP6V1G1/CCL3/CCL5/CTSL/HLA-DMB	1.40492027737841
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/269	122/9376	1.71418124200134	PIK3R1/STAT1/GNAS/PLCB1/IGFBP3/SOS1	1.3645759629925
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/269	46/9376	2.27315338613221	FTL/FTH1/UGT2B7	1.48762316786009
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/269	71/9376	1.96366301900623	PIK3R1/STAT1/PRLR/SOS1	1.40078114899989
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	18/269	480/9376	1.30706319702602	TUBB/ATP5F1E/UBB/CALM2/MT-ND3/PLCB1/COX7C/OPTN/COX7B/UQCRB/COX7A2/UBA52/ATP5PF/COX6C/NDUFB1/GRIA1/UQCRQ/CTNNB1	1.18693000519568
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/269	98/9376	1.77831727486534	PIK3R1/CALM2/PLCB1/DGKB/PIP5K1B	1.33111823675421
NA	NA	hsa04517	IgSF CAM signaling	12/269	299/9376	1.39886362223521	PIK3R1/TUBB/DYNLL1/CDC42/ACTG1/ACTB/MYL12B/NRP1/PMP22/PAK3/BAIAP2/CTNNB1	1.20465577043165
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/269	99/9376	1.76035447410912	PIK3R1/PPP1CB/CALM2/GNAS/PLCB1	1.30708561378424
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/269	99/9376	1.76035447410912	KRT18/CFD/C1S/C3/HLA-DMB	1.30708561378424
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/269	99/9376	1.76035447410912	PIK3R1/DGKB/PLPP3/PIP5K1B/SOS1	1.30708561378424
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/269	73/9376	1.90986403218414	GSTT2B/ADH5/UGT2B7/ADH4	1.34122156224234
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/269	73/9376	1.90986403218414	BST2/MX1/MX2/MLLT3	1.34122156224234
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/269	362/9376	1.34798414426256	PIK3R1/COL1A2/YWHAZ/PRLR/GNB2/FGF7/COL6A1/COL6A3/PPP2R1A/DDIT4/ERBB4/CDK6/HSP90AA1/SOS1	1.16045705797976
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/269	103/9376	1.69199119356119	COL1A2/COL3A1/COL6A1/COL6A3/ELN	1.21362121583791
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/269	76/9376	1.83447466249266	PIK3R1/CALM2/CDK6/SOS1	1.25531461846069
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/269	77/9376	1.81065031622652	PIK3R1/STAT1/CDC42/CDK6	1.22753788680933
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/269	27/9376	2.58185322869338	ELOVL5/HACD3	1.41461935995237
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/269	105/9376	1.65976278987431	UBB/GABARAP/TOMM7/OPTN/UBA52	1.16840467750497
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/269	79/9376	1.76481106771446	GSTT2B/ADH5/UGT2B7/ADH4	1.17319554226502
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/269	28/9376	2.48964418481147	ELOVL5/HACD3	1.3566765530146
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/269	53/9376	1.97292558041664	GNAS/PLCB1/RAB11A	1.22071371705824
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/269	224/9376	1.40042485395645	B2M/PIK3R1/HLA-A/HLA-B/HLA-C/MSX1/HLA-F/NRP1/HLA-DMB	1.04246417532618
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/269	137/9376	1.52649716440995	PIK3R1/ACTG1/ACTB/CTSL/BIRC3/GZMB	1.06688582861189
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/269	29/9376	2.40379438533521	MOB1A/LIMD1	1.3011893157718
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/269	138/9376	1.51543559075481	YWHAZ/PPP1CB/CALM2/SKP1/RBX1/PPP2R1A	1.04833256649289
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/269	110/9376	1.58431902669821	SKP1/RBX1/ID1/BMP8A/PPP2R1A	1.05943503970372
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/269	169/9376	1.44369899474275	PIK3R1/UBB/GABARAP/CTSL/OPTN/UBA52/DDIT4	1.00033815819295
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/269	170/9376	1.43520664771485	PIK3R1/ACTG1/GSTT2B/ACTB/CDK6/SOS1/CTNNB1	0.984143902047362
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/269	31/9376	2.24871087660391	SRP14/SEC61B	1.1968154818318
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/269	86/9376	1.62116365522607	PIK3R1/PAK3/ERBB4/SOS1	0.994538306456085
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/269	116/9376	1.50237149083451	GNB2/GLUL/GNAS/PLCB1/GRIA1	0.935669766600094
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/269	33/9376	2.11242536893095	BCAT1/IDH1	1.10016744557999
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/269	60/9376	1.74275092936803	PIK3R1/CDC42/HSPB1	0.991923544898701
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/269	34/9376	2.05029521102121	SKP1/RBX1	1.05439908947753
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/269	150/9376	1.39420074349442	PIK3R1/CTNNA2/CTNNA3/FGF7/SOS1/CTNNB1	0.836431641336319
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/269	62/9376	1.68653315745293	PIK3R1/EIF4EBP2/CRYAB	0.932101818005202
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/269	243/9376	1.29092661434669	PCBP1/HNRNPK/SRSF7/SNRPD2/SNRPE/SF3B6/SNRPB2/SF3B5/SNRPF	0.789685149238266
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/269	91/9376	1.53208872911475	GNB2/GABRA2/GNAS/GABRP	0.876572641128769
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/269	93/9376	1.49914058440261	STAT1/MAF/HLA-DMB/CD247	0.831369891258372
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/269	93/9376	1.49914058440261	CALM2/GNAS/PLCB1/SLC12A2	0.831369891258372
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/269	216/9376	1.29092661434669	PIK3R1/CDC42/CALM2/PLCB1/CCL3/ABCA1/CCL5/HSP90AA1	0.743424212615
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/269	154/9376	1.35798773716989	PPP1CB/CALM2/ACTG1/ACTB/GNAS/PLCB1	0.769821545085774
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/269	65/9376	1.60869316557049	LIPG/DGKB/PLPP3	0.846313074834714
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/269	66/9376	1.58431902669821	STAT1/MAF/HLA-DMB	0.818693354800179
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/269	38/9376	1.83447466249266	ENPP3/NNMT	0.885833556674721
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/269	158/9376	1.32360830078585	YWHAZ/SKP1/RBX1/PPP2R1A/CDKN1C/CDK6	0.705024086546397
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/269	160/9376	1.30706319702602	HLA-A/HLA-B/HLA-C/PTPRC/HLA-F/HLA-DMB	0.673272127264079
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/269	101/9376	1.38039677573705	CALM2/GNAS/PLCB1/CTNNB1	0.660563640134811
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/269	71/9376	1.47274726425467	CDC42/ATP6V1G1/CCL5	0.687185710096168
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/269	72/9376	1.45229244114002	ISG15/ADAR/IFIH1	0.6621019043407
NA	NA	hsa04082	Neuroactive ligand signaling	7/269	199/9376	1.22605593020866	GNB2/GABRA2/GNAS/PLCB1/P2RY14/GABRP/GRIA1	0.55394441337386
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/269	73/9376	1.43239802413811	PIK3R1/FGF7/CDK6	0.637393646667021
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/269	73/9376	1.43239802413811	PIK3R1/CDK6/SOS1	0.637393646667021
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/269	200/9376	1.21992565055762	TUBB/CDC42/ACTG1/ACTB/PAK3/TMBIM6/BAIAP2	0.540304134217769
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/269	43/9376	1.62116365522607	ADH5/ADH4	0.7016228778947
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/269	168/9376	1.24482209240574	PIK3R1/STAT1/IRF9/PRLR/PIAS1/SOS1	0.550296436925246
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/269	233/9376	1.19673883561753	NID1/COL1A2/ACTG1/COL3A1/ACTB/COL6A1/COL6A3/ELN	0.522634177974177
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/269	15/9376	2.32366790582404	ST6GALNAC5	0.881734138168433
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/269	201/9376	1.21385636871405	BIRC3/GZMB/HOXA10/MAF/CEBPB/IGFBP3/MLLT3	0.526733924767829
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/269	105/9376	1.32781023189945	PIK3R1/STAT1/IRF9/CALM2	0.58053441958779
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/269	106/9376	1.31528372027776	PIK3R1/HSP90AA1/SOS1/CTNNB1	0.561033406538249
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/269	75/9376	1.39420074349442	GLUL/BCAT1/IDH1	0.589057050494878
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/269	75/9376	1.39420074349442	PIK3R1/GSTT2B/BIRC3	0.589057050494878
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/269	75/9376	1.39420074349442	SHISA5/CDK6/IGFBP3	0.589057050494878
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/269	45/9376	1.54911193721603	ABCA1/ABCC9	0.634566523325936
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/269	16/9376	2.17843866171004	MIF	0.810780246314934
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	8/269	238/9376	1.17159726344069	PIK3R1/CDC42/GNB2/CALM2/FGF7/PLA2G2A/PAK3/SOS1	0.460837030196228
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/269	77/9376	1.35798773716989	PIK3R1/CDK6/SOS1	0.542087632105959
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/269	109/9376	1.27908325091232	STAT1/HLA-DMB/CD247/HSP90AA1	0.503676340096666
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/269	46/9376	1.51543559075481	PSME1/PSMB9	0.602263587953004
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/269	174/9376	1.20189719266761	TMEM258/SKP1/RBX1/SEC61B/CRYAB/HSP90AA1	0.461995664269399
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/269	78/9376	1.34057763797541	PLCB1/ALDH6A1/PIP5K1B	0.519090127900284
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/269	17/9376	2.05029521102121	GLUL	0.744895296859619
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/269	47/9376	1.48319228031322	ADH5/ADH4	0.570723137553404
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/269	48/9376	1.45229244114002	BCAT1/ALDH6A1	0.539908033591206
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/269	48/9376	1.45229244114002	PIK3R1/PLCB1	0.539908033591206
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/269	18/9376	1.93638992152003	PRDX1	0.683400941412669
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	6/269	181/9376	1.15541498079648	STAT1/CALM2/CD74/C3/HLA-DMB/CEBPB	0.362852742298174
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/269	82/9376	1.27518360685466	GSTT2B/XDH/UGT2B7	0.430132502433825
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/269	148/9376	1.17753441173516	PIK3R1/FGF7/CDK6/SOS1/CTNNB1	0.374139636637864
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/269	83/9376	1.25981994894074	IDH1/XDH/PRDX1	0.40860876710644
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/269	217/9376	1.12435543830195	PIK3R1/FGF7/GSTT2B/GNAS/UGT2B7/HSP90AA1/SOS1	0.31852588415091
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/269	51/9376	1.36686347401414	PLA2G2A/PLPP3	0.451480764756921
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/269	184/9376	1.13657669306611	PIK3R1/CDC42/MYL12B/NRP1/PAK3/CFL1	0.321554510961401
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/269	119/9376	1.17159726344069	PIK3R1/CCL5/BIRC3/CEBPB	0.32375972043409
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/269	120/9376	1.16183395291202	PIK3R1/CDC42/CALM2/SOS1	0.306635690166084
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/269	154/9376	1.13165644764158	PPP1CB/CALM2/GNAS/PLCB1/PPP2R1A	0.283115759062563
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/269	87/9376	1.20189719266761	PIK3R1/SOS1/CTNNB1	0.325146838064365
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/269	155/9376	1.12435543830195	GNAS/PLCB1/RASD1/CDK6/CTNNB1	0.268296946849086
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/269	55/9376	1.26745522135857	PLPP3/PSAP	0.341881248636042
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/269	89/9376	1.17488826698968	COL1A2/COL6A1/COL6A3	0.284899747743333
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/269	90/9376	1.16183395291202	SCTR/GNAS/UGT2B7	0.265124991245888
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/269	90/9376	1.16183395291202	PIK3R1/STAT1/CD247	0.265124991245888
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/269	56/9376	1.24482209240574	EEF1A1/C3	0.315799016115316
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/269	298/9376	1.05266834659814	CCL4/PRLR/CCL3/CCL5/CXCL13/XCL1/XCL2/BMP8A/CCL4L2	0.158795005127924
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/269	23/9376	1.51543559075481	GLUL	0.425340722036462
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/269	57/9376	1.22298310832844	ELOVL5/HACD3	0.290200961490992
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/269	93/9376	1.12435543830195	PIK3R1/BIRC3/CDK6	0.207126750356755
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/269	163/9376	1.06917234930554	PIK3R1/STAT1/YWHAZ/IFIH1/SOS1	0.153108711773147
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/269	59/9376	1.18152605380883	GSTT2B/IDH1	0.240381496538047
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/269	59/9376	1.18152605380883	PIK3R1/GNAS	0.240381496538047
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/269	26/9376	1.34057763797541	PLA2G2A	0.298862281585597
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/269	98/9376	1.0669903649192	CALM2/GNAS/PLCB1	0.114570367779898
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/269	170/9376	1.02514760551061	CDC42/ACTG1/ACTB/MYL12B/PPP2R1A	0.0568669222869293
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/269	63/9376	1.10650852658288	PRDM6/AASS	0.145775305401683
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/269	99/9376	1.05621268446547	PIK3R1/GNAS/SOS1	0.0966322862282088
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/269	28/9376	1.24482209240574	ATP6V1G1	0.222968945076552
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/269	65/9376	1.07246211038033	GNAS/PLCB1	0.100749663235515
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/269	65/9376	1.07246211038033	PIK3R1/PLCB1	0.100749663235515
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/269	138/9376	1.01029039383654	PIK3R1/PPP1CB/CALM2/SOS1	0.0209293948155265
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/269	29/9376	1.20189719266761	CALM2	0.187140276900793
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/269	103/9376	1.01519471613672	PPP1CB/PPP2R1A/PABPC1	0.0266486481963054
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/269	67/9376	1.04044831604061	ADH5/ADH4	0.0571031993974671
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/269	104/9376	1.00543322848156	PLA2G2A/DGKB/PLPP3	0.00957551270246389
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/269	250/9376	0.975940520446097	HLA-A/HLA-B/CDC42/HLA-C/HLA-F/RAB11A/PIP5K1B	-0.066265901503528
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/269	178/9376	0.979073555824736	SFRP4/SKP1/PLCB1/RBX1/CTNNB1	-0.0484432026961534
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/269	30/9376	1.16183395291202	IDH1	0.15257785009118
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/269	30/9376	1.16183395291202	PLA2G2A	0.15257785009118
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/269	323/9376	0.971192468378469	PIK3R1/MARCKS/HNRNPK/HOXD10/DDIT4/ZFPM2/CDK6/SOX4/SOS1	-0.0905493126891645
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/269	105/9376	0.995857673924588	CCL4/BIRC3/CCL4L2	-0.00733583832938444
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/269	105/9376	0.995857673924588	ACTG1/ACTB/GNAS	-0.00733583832938444
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/269	68/9376	1.02514760551061	PIK3R1/SOS1	0.035768194455726
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/269	69/9376	1.01029039383654	PIK3R1/SOS1	0.0147443555426396
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/269	31/9376	1.12435543830195	UGT2B7	0.119187328787053
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/269	31/9376	1.12435543830195	ALDH6A1	0.119187328787053
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/269	31/9376	1.12435543830195	GLUL	0.119187328787053
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/269	144/9376	0.968194960760017	C3/ADH5/ADH4/CTNNB1	-0.0661002944028174
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/269	107/9376	0.977243511795157	CALM2/GNAS/PLCB1	-0.0406869185925634
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/269	70/9376	0.995857673924588	GSTT2B/UGT2B7	-0.00597841265416549
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/269	32/9376	1.08921933085502	ALDH6A1	0.0868843679014303
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/269	32/9376	1.08921933085502	GABARAP	0.0868843679014303
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/269	32/9376	1.08921933085502	BIRC3	0.0868843679014303
Human Diseases	Immune disease	hsa05310	Asthma	1/269	32/9376	1.08921933085502	HLA-DMB	0.0868843679014303
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/269	71/9376	0.981831509503115	PIK3R1/IDH1	-0.0264097288075502
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/269	110/9376	0.950591416018925	PIK3R1/RBX1/ELOB	-0.0895832289211589
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/269	370/9376	0.942027529388124	SCTR/PRLR/EDNRA/CALCRL/GABRA2/GZMA/P2RY14/GABRP/C3/GRIA1	-0.195537838315555
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/269	112/9376	0.933616569304302	STAT1/BIRC3/HLA-DMB	-0.121462870660292
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/269	226/9376	0.925354475770635	PIK3R1/PPP1CB/EDNRA/CALM2/GNAS/GRIA1	-0.195218762238582
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/269	75/9376	0.929467162329616	GNAS/PLCB1	-0.105397734547242
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/269	191/9376	0.912435041553942	PPP1CB/GNB2/CALM2/GNAS/SOS1	-0.210126854378344
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/269	115/9376	0.909261354452885	PIK3R1/GNB2/PLCB1	-0.168262129224151
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/269	115/9376	0.909261354452885	GNB2/GNAS/PLCB1	-0.168262129224151
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/269	115/9376	0.909261354452885	GNAS/PLCB1/MAFB	-0.168262129224151
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/269	36/9376	0.968194960760017	UGT2B7	-0.032858509383994
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/269	36/9376	0.968194960760017	ENPP3	-0.032858509383994
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/269	116/9376	0.901422894500705	IDH1/ALDH6A1/ADH5	-0.183600421157303
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/269	194/9376	0.898325221323727	TUBB/DYNLL1/ACTG1/ACTB/MYL12B	-0.245934562285827
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/269	37/9376	0.942027529388124	GLUL	-0.060722073523845
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/269	37/9376	0.942027529388124	PLCB1	-0.060722073523845
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/269	37/9376	0.942027529388124	CTNNB1	-0.060722073523845
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/269	195/9376	0.893718425316938	PIK3R1/ACTG1/ACTB/PLCB1/C3	-0.257753399717636
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/269	158/9376	0.88240553385723	PIK3R1/ATP6V1G1/DDIT4/SOS1	-0.256195316603089
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/269	38/9376	0.917237331246331	PIK3R1	-0.0878564113653943
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/269	38/9376	0.917237331246331	PTPRC	-0.0878564113653943
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/269	80/9376	0.871375464684015	PIK3R1/SOS1	-0.198561417567609
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/269	39/9376	0.893718425316938	MTHFD2	-0.114303812037522
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/269	83/9376	0.839879965960496	SKP1/RYBP	-0.251814573764096
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/269	125/9376	0.836520446096654	PIK3R1/PLCB1/PPP2R1A	-0.316226469851008
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/269	85/9376	0.820118084408485	ENPP3/XDH	-0.286312195029897
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/269	166/9376	0.839879965960496	PPP1CB/EDNRA/CALM2/PLCB1	-0.357720651131028
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/269	86/9376	0.810581827613037	GABRA2/PLCB1	-0.303275355524744
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/269	86/9376	0.810581827613037	GNAS/PLCB1	-0.303275355524744
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/269	44/9376	0.792159513349104	TMEM258	-0.237488855036906
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/269	133/9376	0.78620342678257	PIK3R1/GABARAP/SOS1	-0.426770305555616
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/269	91/9376	0.766044364557376	PIK3R1/SOS1	-0.385422765124335
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/269	254/9376	0.823346895764424	EDNRA/CALM2/FGF7/GNAS/PLCB1/ERBB4	-0.490531846136918
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/269	47/9376	0.741596140156608	PIK3R1	-0.305214026908982
NA	NA	hsa04382	Cornified envelope formation	5/269	217/9376	0.803111027358539	S100A6/KRT8/S100A4/KRT18/PPP2R1A	-0.504314366516931
NA	NA	hsa03272	Virion - Hepatitis viruses	1/269	48/9376	0.726146220570012	CD9	-0.326903220338785
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/269	94/9376	0.741596140156608	CEBPB/HSP90AA1	-0.432729249220083
NA	NA	hsa04081	Hormone signaling	5/269	219/9376	0.795776680076726	PIK3R1/PRLR/GNB2/GNAS/PLCB1	-0.525563132144278
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/269	49/9376	0.711326909946134	GNAS	-0.348182919593141
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/269	50/9376	0.697100371747212	OAT	-0.369071191455377
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/269	50/9376	0.697100371747212	HLA-DMB	-0.369071191455377
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/269	140/9376	0.746893255443441	GNB2/CALM2/PLCB1	-0.518561038728661
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/269	142/9376	0.736373632127336	PIK3R1/STAT1/IRF9	-0.544016651735363
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/269	52/9376	0.670288818987704	GNAS	-0.409739963383985
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/269	99/9376	0.704141789643648	ACTG1/ACTB	-0.508594377549805
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/269	143/9376	0.731224166168404	C1S/C3/HLA-DMB	-0.556622719370204
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/269	100/9376	0.697100371747212	HLA-DMB/CD9	-0.523350303375962
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/269	144/9376	0.726146220570012	PIK3R1/ID1/CTNNB1	-0.569149288169714
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/269	144/9376	0.726146220570012	PIK3R1/PLCB1/GRIA1	-0.569149288169714
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/269	54/9376	0.645463307173344	BCAT1	-0.449032349362955
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/269	56/9376	0.622411046202868	TMEM258	-0.48705661704553
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/269	108/9376	0.645463307173344	EEF1A1/SUMO2	-0.636874945686735
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/269	59/9376	0.590763026904417	ENPP3	-0.541922186745787
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/269	154/9376	0.678993868584947	MTHFD2/BCAT1/UGT2B7	-0.690295812983859
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/269	109/9376	0.639541625456158	PIK3R1/PPP1CB	-0.650538340276385
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/269	110/9376	0.633727610679284	PIK3R1/HSP90AA1	-0.664092363233597
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/269	63/9376	0.553254263291438	PLA2G2A	-0.611448663266559
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/269	63/9376	0.553254263291438	RBX1	-0.611448663266559
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/269	63/9376	0.553254263291438	CTNNB1	-0.611448663266559
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/269	117/9376	0.595812283544626	ACTG1/ACTB	-0.756080625779793
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/269	66/9376	0.528106342232736	UGT2B7	-0.661173407221506
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/269	300/9376	0.697100371747212	CDC42/FGF7/HSPB1/ERBB4/MAP3K20/SOS1	-0.91640243393791
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/269	122/9376	0.57139374733378	PIK3R1/PPP2R1A	-0.81893188392578
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/269	128/9376	0.544609665427509	ENPP3/XDH	-0.891536222382573
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/269	76/9376	0.458618665623166	DBI	-0.81440927298493
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/269	78/9376	0.446859212658469	PABPC1	-0.843067453737852
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/269	79/9376	0.441202766928615	ATP6V1G1	-0.857176955909499
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/269	90/9376	0.387277984304007	PIK3R1	-1.00379380299681
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	4/269	250/9376	0.557680297397769	ATP6V1G1/CTSL/PSAP/CD164	-1.2182605105834
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/269	157/9376	0.444012975635167	ABCA1/CEBPB	-1.20738752623849
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/269	183/9376	0.190464582444593	NOP10	-1.90067069544928
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/269	449/9376	0.0776281037580414	CALM2	-3.44231472799886