category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	61/481	268/9376	4.43677661588109	PSMA7/ATP5F1E/TUBA4A/CALM1/UBC/COX6A2/NDUFB2/TXN/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/UBB/NDUFA13/NDUFA12/NFE2L2/PSMA6/UQCRQ/ADORA2A/ATP5MC1/PSMB1/NDUFA6/PARK7/CYCS/ATP5PF/PSMB6/COX7B/PSMA2/CALM3/UQCR11/PSMB3/NDUFA11/NDUFAB1/BAX/COX6C/PSMD8/NDUFB8/PSMD7/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/PSMC5/COX5B/PSMA1/PSMB2/COX6A1/UQCRB/ATP5PB/UBE2L6/PSMC4/TUBA1A/PSMD1/PSMA5/NDUFB3/EIF2AK3/UQCR10/COX8A/NDUFB1/NDUFA5	13.2737120129817
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	42/481	138/9376	5.93256801952454	ATP5F1E/COX6A2/NDUFB2/ATP6V0E1/MT-CO3/COX7A2/NDUFA4/PPA1/MT-ND5/NDUFS6/NDUFA13/NDUFA12/UQCRQ/ATP5MC1/ATP6V1G1/NDUFA6/CYCS/ATP5PF/COX7B/COX17/ATP5MG/UQCR11/NDUFA11/NDUFAB1/COX6C/NDUFB8/NDUFC2/ATP5F1C/ATP6V0E2/MT-ND6/NDUFB6/COX5B/ATP6V0B/ATP6V1F/COX6A1/UQCRB/ATP5PB/NDUFB3/UQCR10/COX8A/NDUFB1/NDUFA5	13.574031330381
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	58/481	275/9376	4.11119259119259	PSMA7/ATP5F1E/TUBA4A/PIK3R1/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/PSMA6/UQCRQ/ATP5MC1/PSMB1/NDUFA6/CYCS/RAC2/ATP5PF/PSMB6/COX7B/PSMA2/UQCR11/HSPA8/PSMB3/NDUFA11/NDUFAB1/BAX/COX6C/PSMD8/NDUFB8/PSMD7/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/PSMC5/COX5B/CYBA/PSMA1/PSMB2/CSNK2B/COX6A1/UQCRB/ATP5PB/PRNP/PSMC4/TUBA1A/PSMD1/PSMA5/NDUFB3/EIF2AK3/UQCR10/COX8A/NDUFB1/NDUFA5	12.1768199883034
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	64/481	368/9376	3.39003886829974	PFN1/PSMA7/ATP5F1E/TUBA4A/ACTB/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/SRSF7/NDUFS6/NDUFA13/NDUFA12/PSMA6/UQCRQ/HNRNPA3/ATP5MC1/PSMB1/NDUFA6/CYCS/ATP5PF/PSMB6/COX7B/PSMA2/TNFRSF1B/ANXA11/UQCR11/PSMB3/NDUFA11/NDUFAB1/BAX/COX6C/PSMD8/NDUFB8/PSMD7/NDUFC2/ALYREF/ATP5F1C/MT-ND6/NDUFB6/MAP2K3/PSMC5/COX5B/PSMA1/PSMB2/COX6A1/UQCRB/ATP5PB/PSMC4/TUBA1A/PSMD1/PSMA5/NDUFB3/ANXA7/EIF2AK3/UQCR10/CCS/COX8A/RAB1A/NDUFB1/NDUFA5/VCP	10.8767684844675
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/481	308/9376	3.48084348084348	PSMA7/ATP5F1E/TUBA4A/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/PSMA6/UQCRQ/ATP5MC1/PSMB1/NDUFA6/CYCS/ATP5PF/PSMB6/COX7B/PSMA2/UQCR11/PSMB3/NDUFA11/NDUFAB1/BAX/POLR2K/COX6C/PSMD8/NDUFB8/PSMD7/NDUFC2/POLR2L/ATP5F1C/MT-ND6/NDUFB6/PSMC5/COX5B/PSMA1/PSMB2/COX6A1/UQCRB/ATP5PB/PSMC4/TUBA1A/PSMD1/TGM2/PSMA5/NDUFB3/UQCR10/COX8A/POLR2E/NDUFB1/NDUFA5	10.2944741572906
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	21/481	46/9376	8.89885202928681	PSME2/PSMA7/PSME1/PSMB9/POMP/PSMA6/PSMB1/PSMB6/PSMA2/PSME4/PSMB3/PSMD8/PSMD7/PSMB10/PSMC5/PSMA1/IFNG/PSMB2/PSMC4/PSMD1/PSMA5	12.4878384649995
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/481	205/9376	3.99363115460676	COL3A1/ATP5F1E/PIK3R1/COX6A2/NDUFB2/CTSD/MT-CO3/PPP1CB/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/UQCRQ/ATP5MC1/NDUFA6/RAC2/ATP5PF/COX7B/COL1A1/UQCR11/NDUFA11/PPP1CA/NDUFAB1/COX6C/NDUFB8/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/COX5B/CYBA/COX6A1/UQCRB/ATP5PB/NDUFB3/UQCR10/COX8A/SMAD3/NDUFB1/NDUFA5	10.077482991784
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	59/481	388/9376	2.96409970636775	CTNNB1/PSMA7/ATP5F1E/TUBA4A/CALM1/PIK3R1/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/PSMA6/UQCRQ/EIF2AK2/ATP5MC1/PSMB1/NDUFA6/CYCS/ATP5PF/PSMB6/COX7B/PSMA2/CALM3/UQCR11/PSMB3/NDUFA11/NDUFAB1/COX6C/PSMD8/CSF1/NDUFB8/PSMD7/MME/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/PSMC5/COX5B/PSMA1/PSMB2/CSNK2B/COX6A1/UQCRB/ATP5PB/PSMC4/TUBA1A/PSMD1/PSMA5/NDUFB3/EIF2AK3/UQCR10/COX8A/NDUFB1/NDUFA5	9.18825547026628
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	67/481	480/9376	2.72085932085932	CTNNB1/PSMA7/ATP5F1E/TUBA4A/CALM1/UBC/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/UBB/NDUFA13/NDUFA12/PSMA6/UQCRQ/ATP5MC1/PSMB1/NDUFA6/PARK7/CYCS/ATP5PF/PSMB6/COX7B/PSMA2/TNFRSF1B/CALM3/UQCR11/PSMB3/NDUFA11/NDUFAB1/BAX/COX6C/PSMD8/CSF1/NDUFB8/PSMD7/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/MAP2K3/PSMC5/COX5B/PSMA1/PSMB2/CSNK2B/COX6A1/UQCRB/ATP5PB/PRNP/UBE2L6/PSMC4/TUBA1A/PSMD1/PSMA5/NDUFB3/EIF2AK3/UQCR10/CCS/COX8A/RAB1A/NDUFB1/NDUFA5/VCP	9.00023398510289
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/481	235/9376	3.40085814128367	ATP5F1E/ACTB/COX6A2/NDUFB2/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFAF8/NDUFA12/UQCRQ/ATP5MC1/NDUFA6/ATP5PF/COX7B/COX17/ATP5MG/UQCR11/NDUFA11/NDUFAB1/COX6C/COX20/NDUFB8/NDUFC2/BMP8A/ATP5F1C/MT-ND6/NDUFB6/MAP2K3/COX5B/COX6A1/UQCRB/ATP5PB/RPS6KA2/NDUFB3/UQCR10/COX8A/NDUFB1/NDUFA5	8.66739874168637
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/481	205/9376	3.51819887429644	CD44/ISG15/HLA-C/B2M/PIK3R1/CALR/HLA-A/HLA-DRB5/STAT3/PDIA3/HLA-DRB1/EIF2AK2/CYCS/CDK6/TNFAIP3/HLA-DPB1/HLA-DQA1/HLA-DRA/BAX/PSMD8/PSMD7/ENTPD1/VIM/HLA-G/MAP2K3/RUNX3/PSMC5/IRF9/MYC/HLA-DQB1/OAS1/HLA-DPA1/PSMC4/PSMD1/LYN/OAS3/CD58	8.47703174340642
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	31/481	157/9376	3.84888170875432	PIK3R1/COX6A2/NDUFB2/CDC42/MT-CO3/COX7A2/NDUFA4/NDUFS6/NDUFA13/NDUFA12/UQCRQ/NDUFA6/CYCS/COX7B/UQCR11/NDUFA11/NDUFAB1/BAX/COX6C/NDUFB8/NDUFC2/NDUFB6/COX5B/COX6A1/UQCRB/NDUFB3/EIF2AK3/UQCR10/COX8A/NDUFB1/NDUFA5	8.37081098833733
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	38/481	227/9376	3.26309908688763	ATP5F1E/PIK3R1/COX6A2/NDUFB2/HIF1A/MT-CO3/COX7A2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/NFE2L2/UQCRQ/ATP5MC1/NDUFA6/ATP5PF/COX7B/UQCR11/NDUFA11/NDUFAB1/COX6C/NDUFB8/NDUFC2/ATP5F1C/MT-ND6/NDUFB6/COX5B/CYBA/PRKD3/COX6A1/UQCRB/ATP5PB/NDUFB3/UQCR10/COX8A/NDUFB1/NDUFA5	8.02629068534846
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/481	180/9376	3.35708015708016	BST2/HLA-C/B2M/PIK3R1/CALR/SRSF2/PPP1CB/HLA-A/HLA-DRB5/SRSF7/PDIA3/HLA-DRB1/EIF2AK2/CYCS/HLA-DPB1/CD74/IFNGR1/HLA-DQA1/PPP1CA/HLA-DRA/BAX/SRSF5/ALYREF/HLA-G/IRF9/IFNG/HLA-DQB1/OAS1/HLA-DPA1/OAS3/IFIH1	7.42499769608121
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/481	174/9376	3.36081439529715	CALR/SSR4/HSP90B1/SEC61B/DAD1/SEC61G/SELENOS/PDIA3/NFE2L2/BCAP31/KRTCAP2/PDIA6/SKP1/HSPA8/BAX/LMAN1/MAN1A1/OSTC/RBX1/RPN2/BAG1/SAR1B/UFD1/SEC24B/EIF2AK3/SEC23A/SSR3/LMAN2/VCP/STT3B	7.30938023457102
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	19/481	82/9376	4.51660666294813	PSME2/HLA-C/B2M/PSME1/CALR/HLA-A/HLA-DRB5/PDIA3/HLA-DRB1/HLA-DPB1/CD74/HLA-DQA1/HSPA8/KLRC2/HLA-DRA/HLA-G/IFNG/HLA-DQB1/HLA-DPA1	7.43728778735073
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/481	155/9376	3.14398766011669	HLA-C/ITGB2/TUBA4A/ACTB/CALR/ATP6V0E1/SEC61B/HLA-A/HLA-DRB5/SEC61G/HLA-DRB1/ATP6V1G1/HLA-DPB1/ITGAM/HLA-DQA1/HLA-DRA/ATP6V0E2/HLA-G/CYBA/ATP6V0B/ATP6V1F/HLA-DQB1/HLA-DPA1/TUBA1A/FCGR3A	6.25870266274713
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/481	39/9376	5.99776107468415	HLA-C/GZMB/HLA-A/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-G/IFNG/HLA-DQB1/HLA-DPA1	7.2725935172651
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	26/481	173/9376	2.92954225902203	ACTB/PIK3R1/HLA-DRB5/MX1/HLA-DRB1/EIF2AK2/CYCS/CDK6/HLA-DPB1/IFNGR1/HLA-DQA1/HLA-DRA/BAX/ADAR/RSAD2/IRF9/IFNG/MX2/PABPN1/HLA-DQB1/OAS1/KPNA6/HLA-DPA1/OAS3/IFIH1/KPNA2	5.95659174444937
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	12/481	44/9376	5.31619731619732	HLA-C/GZMB/HLA-A/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-G/IFNG/HLA-DQB1/HLA-DPA1	6.67306666771813
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	12/481	45/9376	5.1980595980596	HLA-C/GZMB/HLA-A/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-G/IFNG/HLA-DQB1/HLA-DPA1	6.56411169092034
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/481	66/9376	4.13482013482013	HLA-DRB5/STAT3/HLA-DRB1/HLA-DPB1/IFNGR1/HLA-DQA1/GATA3/HLA-DRA/IFNG/HLA-DQB1/HLA-DPA1/IL4R/SMAD3/IL21R	5.94285255059826
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/481	70/9376	3.8985446985447	HLA-C/ITGB2/ACTB/HLA-A/HLA-DRB5/HLA-DRB1/CYCS/RAC2/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-G/HLA-DQB1/HLA-DPA1	5.66021200479482
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	27/481	214/9376	2.4593623098296	BST2/CFL1/HLA-C/B2M/CALM1/PIK3R1/CALR/HLA-A/AP1S1/PDIA3/CXCR4/GNG2/CYCS/RAC2/APOBEC3G/SKP1/TNFRSF1B/CALM3/BAX/RBX1/HLA-G/MAP2K3/GNB2/RNF7/GNB1/GNG5/ELOB	5.02180759174094
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/481	232/9376	2.35257007670801	TMSB4X/PFN1/CFL1/ITGB2/ARPC3/ACTB/PIK3R1/CDC42/PPP1CB/BRK1/TIAM1/CXCR4/MYL12B/ARPC5/GNA13/ITGB7/F2R/MSN/RAC2/RHOA/ITGAM/PDGFRA/PPP1CA/MYL12A/ACTN1/MYH9/ACTR3/ACTN4	4.85088366167802
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/481	196/9376	2.48631677203106	CTNNB1/HLA-C/CALM1/UBC/PIK3R1/HIF1A/HLA-A/STAT3/UBB/EIF2AK2/GNG2/CYCS/CSF2/CDK6/IFNGR1/CALM3/ZFP36/BAX/HLA-G/GNB2/IRF9/GNB1/MYC/GNG5/LYN	4.88993711143893
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/481	95/9376	3.2829850093008	ITGB2/ATP6V0E1/HLA-DRB5/HLA-DRB1/ATP6V1G1/CSF2/HLA-DPB1/HLA-DQA1/HLA-DRA/CSF1/ATP6V0E2/ATP6V0B/IFNG/ATP6V1F/HLA-DQB1/HLA-DPA1	5.20059071525293
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/481	149/9376	2.61647295204342	NDUFB2/NDUFA4/MT-ND5/NDUFS6/NDUFA13/NDUFA12/GNG2/NDUFA6/NDUFA11/NDUFAB1/NDUFB8/NDUFC2/MT-ND6/NDUFB6/GNB2/GNB1/GNG5/NDUFB3/NDUFB1/NDUFA5	4.62505089500502
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/481	54/9376	3.97073997073997	HLA-C/GZMB/HLA-A/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-G/HLA-DQB1/HLA-DPA1	5.09087191458361
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	25/481	212/9376	2.29867022319853	CTNNB1/PFN1/ITGB2/ACTB/CALM1/PIK3R1/CDC42/TIAM1/IGF1/SIPA1L1/ADORA2A/F2R/RAC2/RHOA/ITGAM/CALM3/PDGFRA/PARD6G/CSF1/MAP2K3/TLN1/PRKD3/RALA/PRKCI/RASGRP3	4.44743360432257
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	26/481	227/9376	2.23264674365996	CTNNB1/HLA-C/B2M/CALM1/PIK3R1/CALR/HLA-A/STAT3/PDIA3/CXCR4/GNA13/GNG2/CYCS/RAC2/RHOA/CDK6/CALM3/CCL4/PDGFRA/BAX/AKAP13/HLA-G/GNB2/GNB1/MYC/GNG5	4.37169593425508
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/481	87/9376	3.13676010227734	COX6A2/MT-CO3/COX7A2/TPM3/UQCRQ/COX7B/UQCR11/COX6C/COX5B/COX6A1/UQCRB/UQCR10/TPM4/COX8A	4.65603365625022
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/481	31/9376	5.03038025618671	SPCS2/SEC61B/SEC61G/SPCS1/SRP14/SEC11C/SPCS3/TMEM208	5.2266379427992
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	16/481	109/9376	2.86131720994106	HIF1A/HLA-DRB5/STAT3/IRF4/HLA-DRB1/HLA-DPB1/IFNGR1/HLA-DQA1/GATA3/HLA-DRA/IFNG/HLA-DQB1/HLA-DPA1/IL4R/SMAD3/IL21R	4.54516088488263
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	22/481	181/9376	2.36928130850783	ITGB2/CALM1/CTSD/HLA-DRB5/HLA-DRB1/FCER1G/CYCS/RHOA/HLA-DPB1/CD74/IFNGR1/ITGAM/HLA-DQA1/CALM3/HLA-DRA/BAX/KSR1/ATP6V0B/IFNG/HLA-DQB1/HLA-DPA1/FCGR3A	4.3255496430142
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/481	78/9376	3.24878724878725	ITGB2/HLA-DRB5/HLA-DRB1/HLA-DPB1/IFNGR1/ITGAM/HLA-DQA1/HLA-DRA/CYBA/IFNG/HLA-DQB1/HLA-DPA1/FCGR3A	4.63752325745711
Human Diseases	Immune disease	hsa05310	Asthma	8/481	32/9376	4.87318087318087	HLA-DRB5/HLA-DRB1/FCER1G/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-DQB1/HLA-DPA1	5.10342284037122
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/481	248/9376	2.12219167057877	CTNNB1/PFN1/ARPC3/TUBA4A/ACTB/ARF6/CDC42/TXN/HSP90B1/CYTH1/BRK1/MYL12B/ARPC5/FLNA/CYCS/RHOA/SKP1/BAX/RHOB/MYL12A/ACTR3/MAP2K3/ARL8A/SNX9/MYC/RALA/TUBA1A	4.16476274344537
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	10/481	50/9376	3.8985446985447	HLA-DRB5/CXCR4/CCR9/HLA-DRB1/ITGB7/HLA-DPB1/HLA-DQA1/HLA-DRA/HLA-DQB1/HLA-DPA1	4.77862002631545
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/481	136/9376	2.57991928580164	PIK3R1/MX1/STAT3/EIF2AK2/MSN/CYCS/CDK6/TNFAIP3/HSPA8/BAX/CBLB/ADAR/IRF9/MX2/CSNK2B/OAS1/OAS3/IFIH1	4.31572307004649
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/481	224/9376	2.17552717552718	HLA-C/ITGB2/B2M/PIK3R1/CALR/HLA-A/TSPO/HLA-DRB5/RANBP1/HLA-DRB1/CSF2/HLA-DPB1/HLA-DQA1/ZFP36/HLA-DRA/BAX/ANAPC11/RAN/HLA-G/TLN1/MYC/HLA-DQB1/HLA-DPA1/SMAD3/ANAPC16	4.14079640022605
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	23/481	200/9376	2.2416632016632	ARPC3/TUBA4A/ACTB/ARF6/CDC42/CYTH1/BRK1/ARPC5/GNA13/F2R/CYCS/WIPF3/TMED10/RHOA/MYO5B/TMBIM6/BAX/MYH9/ACTR3/TUBA1A/SEC24B/RAB1A/NCL	4.12740709115355
NA	NA	hsa04517	IgSF CAM signaling	30/481	299/9376	1.95579165478831	MYL6/CTNNB1/ITGB2/ARPC3/TUBA4A/ACTB/PIK3R1/ARF6/CDC42/PPFIA2/MYL12B/ARPC5/MSN/RHOA/ITGAM/EPB41L3/SH2D1B/SLIT3/PARD6G/MYL12A/ACTN1/MYH9/ACTR3/FOXO1/LRFN4/TUBA1A/PRKCI/LYN/NLGN1/ACTN4	3.90582571971512
NA	NA	hsa04518	Integrin signaling	19/481	154/9376	2.40494640494641	CTNNB1/ITGB2/ACTB/PIK3R1/CDC42/IGF1/ITGB7/FLNA/RAC2/ITGAM/COL1A1/PDGFRA/COL6A1/ACTN1/TLN1/PARVG/LAMA4/COL4A2/ACTN4	4.0878293641328
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/481	156/9376	2.37411375872914	CTNNB1/PIK3R1/YWHAZ/PPP2R2B/MX1/STAT3/EIF2AK2/CD81/CYCS/CDK6/BAX/RSAD2/YWHAB/IRF9/IFNG/MX2/MYC/OAS1/OAS3	4.02443323582066
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/481	333/9376	1.87317462993139	CTNNB1/ISG15/HLA-C/PIK3R1/ATP6V0E1/CDC42/HLA-A/PPP2R2B/MX1/BCAP31/ITGB7/EIF2AK2/ATP6V1G1/HES4/CDK6/COL1A1/COL6A1/BAX/OASL/PARD6G/ATP6V0E2/FOXO1/HLA-G/IRF9/ATP6V0B/MX2/ATP6V1F/LFNG/PRKCI/LAMA4/COL4A2/JAG1	3.77269902922651
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/481	98/9376	2.78467478467478	BIN1/CFL1/ARPC3/PIK3R1/ARF6/CDC42/GAB2/ARPC5/RAC2/ACTR3/PLPP1/LYN/PLPP3/FCGR3A	4.12981066573551
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	26/481	250/9376	2.02724324324324	BIN1/HLA-C/ARPC3/ARF6/ARF5/CDC42/HLA-A/CYTH1/CXCR4/ARPC5/WIPF3/RHOA/CAPZA1/PDGFRA/HSPA8/PARD6G/CBLB/ACTR3/HLA-G/ARFGAP3/MVB12B/SNF8/PRKCI/GRK5/SMAD3/STAM	3.82814399774913
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/481	253/9376	2.00320478581348	CD44/PFN1/ARPC3/ACTB/UBC/PIK3R1/ARF6/CDC42/CYTH1/UBB/MYL12B/ARPC5/CYCS/CSF2/RHOA/SKP1/FNBP1/BAX/MYL12A/ACTN1/RBX1/ACTR3/FOXO1/TLN1/UBE2N/ACTN4	3.76154462680594
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/481	243/9376	2.00542422764645	DDX5/SRSF2/SRSF7/SNRPB/TRA2A/HNRNPA3/LSM7/HNRNPM/HSPA8/SF1/SRSF5/SF3B5/SNRPD2/ALYREF/TXNL4A/RBM8A/SNRPE/LSM4/LSM3/SNRPF/SF3B6/SNRPA1/SNU13/SNRPG/SRSF10	3.69258885306546
Organismal Systems	Immune system	hsa04611	Platelet activation	16/481	126/9376	2.47526647526648	COL3A1/ACTB/PIK3R1/PPP1CB/MYL12B/GNA13/FCER1G/F2R/RHOA/COL1A1/PPP1CA/VAMP8/MYL12A/TLN1/PRKCI/LYN	3.8767703900324
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	22/481	203/9376	2.11251190561535	CTNNB1/ACTB/PIK3R1/CDC42/PPP1CB/IGF1/MYL12B/ITGB7/FLNA/RAC2/RHOA/COL1A1/PDGFRA/COL6A1/PPP1CA/MYL12A/ACTN1/TLN1/PARVG/LAMA4/COL4A2/ACTN4	3.72633752265075
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/481	116/9376	2.52061079647287	CTNNB1/ITGB2/ACTB/PIK3R1/CDC42/CXCR4/MYL12B/MSN/RAC2/RHOA/ITGAM/MYL12A/ACTN1/CYBA/ACTN4	3.83201121234745
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/481	93/9376	2.72478930543447	HLA-DRB5/HLA-DRB1/HLA-DPB1/IFNGR1/HLA-DQA1/GATA3/HLA-DRA/RUNX3/IFNG/HLA-DQB1/HLA-DPA1/IL4R/JAG1	3.88703588368668
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/481	51/9376	3.43989238106885	ACTB/ATP6V0E1/SEC61B/SEC61G/KDELR2/ATP6V1G1/ATP6V0E2/ATP6V0B/ATP6V1F	4.06271669581438
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/481	170/9376	2.17859850801027	MYL6/ARPC3/TUBA4A/ACTB/CDC42/PPP2R2B/TIAM1/MYL12B/ARPC5/MSN/RHOA/PARD6G/MYL12A/ACTN1/MYH9/ACTR3/TUBA1A/PRKCI/ACTN4	3.60611907027746
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/481	112/9376	2.43659043659044	HLA-DRB5/STAT3/HLA-DRB1/CYCS/HLA-DPB1/IFNGR1/HLA-DQA1/HSPA8/HLA-DRA/MAP2K3/IFNG/HLA-DQB1/HLA-DPA1/LAMA4	3.55654173447017
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/481	100/9376	2.53405405405405	CD44/HLA-DRB5/HLA-DRB1/CSF2/HLA-DPB1/ITGAM/HLA-DQA1/HLA-DRA/CSF1/MME/HLA-DQB1/HLA-DPA1/IL4R	3.58629072411807
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/481	20/9376	4.87318087318087	DHCR7/CYP51A1/SQLE/EBP/MSMO1	4.03202178525298
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/481	144/9376	2.16585816585817	PSMA7/PIK3R1/PSMA6/PSMB1/CYCS/PSMB6/PSMA2/PSMB3/PSMD8/PSMD7/PSMC5/PSMA1/PSMB2/PSMC4/PSMD1/PSMA5	3.27841755991822
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	15/481	133/9376	2.19842746158536	HLA-C/ITGB2/GZMB/PIK3R1/HLA-A/HCST/FCER1G/CSF2/RAC2/IFNGR1/SH2D1B/KLRC2/HLA-G/IFNG/FCGR3A	3.23680321154065
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	20/481	204/9376	1.91105132281603	CD44/CTNNB1/ACTB/CD63/PIK3R1/DDX5/CDC42/HIF1A/PPP1CB/TIAM1/STAT3/IGF1/FLNA/MSN/RHOA/COL1A1/PPP1CA/DCN/HPSE2/MYC	3.05922277571198
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	22/481	238/9376	1.80184839008368	ISG15/PIK3R1/RPS3A/RPL12/MX1/STAT3/EIF2AK2/RPL21/RPL27/CSF2/RPS27L/RPL36AL/RPL22/ADAR/RPS29/IRF9/MX2/OAS1/RPL23A/OAS3/IFIH1/RPS17	2.91367000714168
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/481	142/9376	2.05909050979474	CTNNB1/ACTB/CALM1/PIK3R1/TXN/HSP90B1/SUMO2/NFE2L2/GSTP1/RAC2/RHOA/CALM3/SUMO1/CYBA/IFNG	2.95711023018628
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/481	103/9376	2.27099691177361	COL3A1/ITGB2/PIK3R1/SERPINB9/CSF2/ITGAM/COL1A1/ACTN1/IFNG/LAMA4/COL4A2/ACTN4	3.01604750670046
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/481	44/9376	3.1011151011151	DAD1/KRTCAP2/B4GALT1/MAN1A1/OSTC/RPN2/STT3B	3.24843377610993
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/481	93/9376	2.30559095075224	CTNNB1/ACTB/CDC42/MYL12B/RAC2/RHOA/MYL12A/ACTN1/CSNK2B/SMAD3/ACTN4	2.94231814807793
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/481	160/9376	1.94927234927235	HLA-C/ITGB2/HLA-A/HLA-DRB5/HLA-DRB1/ITGB7/HLA-DPB1/ITGAM/HLA-DQA1/SELL/HLA-DRA/HLA-G/HLA-DQB1/HLA-DPA1/NLGN1/CD58	2.81620839809033
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/481	193/9376	1.8179742117566	XCL1/XCL2/PIK3R1/CDC42/TIAM1/STAT3/CXCR4/CCR9/GNG2/RAC2/RHOA/CCL4/CXCR6/GNB2/GNB1/GNG5/GRK5/LYN	2.66999946549133
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/481	110/9376	2.12647892647893	PIK3R1/HIF1A/STAT3/IGF1/LDHA/IFNGR1/ENO1/RBX1/PGK1/TIMP1/IFNG/ELOB	2.76349362095998
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/481	238/9376	1.71994619053443	CALM1/PIK3R1/ARF6/CDC42/TIAM1/IGF1/GAB2/GNG2/PLAAT2/RAC2/RHOA/CALM3/PDGFRA/RASA3/CSF1/KSR1/GNB2/GNB1/GNG5/RALA/RASGRP3	2.61606264732557
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/481	99/9376	2.16585816585817	ITGB2/HLA-DRB5/HLA-DRB1/HLA-DPB1/ITGAM/HLA-DQA1/HLA-DRA/HLA-DQB1/KRT10/HLA-DPA1/FCGR3A	2.7117193373937
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/481	142/9376	1.92181780914175	UBC/UBB/SKP1/UBE2M/CBLB/UBE2F/RBX1/ANAPC11/RNF7/UBE2L6/UBE2N/UBA6/ELOB/ANAPC16	2.57382806150279
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/481	105/9376	2.04209484209484	UBC/HIF1A/UBB/TOMM7/GABARAP/CSNK2B/USP15/CCZ1/GABARAPL1/EIF2AK3/VCP	2.4970302610115
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/481	21/9376	3.71289971289971	CHST12/CHST7/CHSY3/CHPF	2.89405440575831
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/481	137/9376	1.84967449201026	CTSW/GZMB/TUBA4A/ACTB/PIK3R1/MCL1/CTSD/CYCS/BAX/LMNA/TUBA1A/EIF2AK3/CTSC	2.329622653286
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/481	56/9376	2.43659043659044	DAD1/KRTCAP2/B4GALT1/MAN1A1/OSTC/RPN2/STT3B	2.50728803683981
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/481	56/9376	2.43659043659044	ITGB2/CYCS/ITGAM/HSPA8/SAR1B/RAB1A/VCP	2.50728803683981
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/481	69/9376	2.26002591219983	PIK3R1/ALOX5AP/GAB2/FCER1G/CSF2/RAC2/MAP2K3/LYN	2.44278005278986
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/481	110/9376	1.94927234927235	ID2/EMP3/RHOA/SKP1/BMP8A/RBX1/DCN/IFNG/MYC/TFDP1/SMAD3	2.32876800453569
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/481	157/9376	1.73820464266324	HLA-C/CALM1/PIK3R1/PPP1CB/HLA-A/ZFP36L2/CDK6/CALM3/PPP1CA/FOXO1/HLA-G/MAP2K3/MYC/SMAD3	2.16905163715942
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/481	157/9376	1.73820464266324	CTNNB1/ID2/ITGB2/ACTB/YWHAZ/PPP1CB/PPP2R2B/PPP1CA/PARD6G/BMP8A/YWHAB/MYC/PRKCI/SMAD3	2.16905163715942
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/481	143/9376	1.77206577206577	HLA-DRB5/SSB/SNRPB/HLA-DRB1/HLA-DPB1/HLA-DQA1/HLA-DRA/ACTN1/IFNG/HLA-DQB1/HLA-DPA1/ACTN4/FCGR3A	2.16339638894612
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/481	14/9376	4.17701217701218	CHST2/B4GALT1/ST3GAL1	2.7662012869373
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/481	87/9376	2.01648863717829	CTNNB1/PIK3R1/CYCS/RAC2/RHOA/BAX/MYC/RALA/SMAD3	2.21494462614397
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	17/481	205/9376	1.61646975305512	HLA-C/PIK3R1/CDC42/YWHAZ/HLA-A/STAT3/RANBP1/EIF2AK2/RHOA/CDK6/BAX/ACTN1/HLA-G/YWHAB/IRF9/LYN/ACTN4	2.07522674989608
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	8/481	77/9376	2.02521802521803	PIK3R1/CDC42/STAT3/RAC2/CDK6/BAX/RALA/SMAD3	2.10052895345747
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/481	91/9376	1.92785177400562	PDE4D/GNG2/PDE8A/PDE4B/GNB2/GNB1/GNG5/PDE3B/GRK5	2.06820481431589
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/481	78/9376	1.99925369156138	CTNNB1/ARPC3/ACTB/PIK3R1/CDC42/ARPC5/RHOA/ACTR3	2.06069393056853
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/481	138/9376	1.69501943414987	CALM1/YWHAZ/PPP1CB/IGF1/SKP1/CALM3/PPP1CA/RBX1/ANAPC11/YWHAB/RPS6KA2/ANAPC16	1.91263770454469
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/481	138/9376	1.69501943414987	ARPC3/ACTB/PIK3R1/ARF6/CDC42/ARPC5/WIPF3/RAC2/RHOA/ACTR3/MAP2K3/RPS6KA2	1.91263770454469
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/481	28/9376	2.78467478467478	ATP6V0E1/ATP6V1G1/ATP6V0E2/ATP6V1F	2.1991960743972
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/481	233/9376	1.505875634631	COL3A1/ACTB/EMD/TPM3/ITGB7/COL1A1/CAPZA1/COL6A1/ENO1/VIM/MYH9/LMNA/FMNL1/TLN1/DCN/TPM4/COL4A2/NID1	1.81828754144042
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/481	250/9376	1.48144698544699	CTSW/CD63/LAPTM4A/ATP6V0E1/CTSD/AP1S1/ATP6V1G1/MCOLN2/LAMTOR5/LITAF/CTSA/VAMP8/NPC2/ATP6V0E2/ARL8A/ATP6V0B/ATP6V1F/CD164/CTSC	1.7941693943436
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	9/481	99/9376	1.77206577206577	CALM1/PIK3R1/PPP1CB/PRKCH/IGF1/CALM3/PPP1CA/TRPV2/MAP2K3	1.7957807777668
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/481	85/9376	1.83460926990339	APRT/GUK1/NME2/NME1/ENTPD1/CTPS1/CMPK2/DUT	1.79740786223958
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/481	71/9376	1.92181780914175	ATP6V0E1/CDC42/ATP6V1G1/ATP6V0E2/ATP6V0B/ATP6V1F/LYN	1.81301451078879
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/481	101/9376	1.73697536073774	COL3A1/PIK3R1/CDC42/STAT3/COL1A1/BAX/FOXO1/SMAD3/COL4A2	1.73157734966493
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/481	73/9376	1.86916526642554	BST2/MX1/CXCR4/APOBEC3G/RAN/MX2/NELFA	1.7335544313277
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/481	59/9376	1.9823108636668	NME2/NME1/ENTPD1/CTPS1/CMPK2/DUT	1.76003824636984
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/481	149/9376	1.56988377122605	PIK3R1/ARF6/CYTH1/GAB2/GNA13/FCER1G/F2R/RHOA/PDGFRA/PLPP1/RALA/PLPP3	1.63055091198772
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	11/481	134/9376	1.60014894343253	MYL6/CALM1/PPP1CB/PRKCH/GNA13/ADORA2A/RHOA/CALM3/PPP1CA/MYH9/CALCRL	1.6270978196898
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/481	90/9376	1.73268653268653	EML4/PIK3R1/HIF1A/STAT3/IFNGR1/MAP2K3/IFNG/CSNK2B	1.62409086725909
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/481	76/9376	1.79538242696137	CALM1/PIK3R1/IGF1/CDK6/CALM3/PDGFRA/BAX	1.61892419454711
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/481	93/9376	1.6767934187289	PIK3R1/CYCS/CDK6/BAX/MYC/TRAF4/LAMA4/COL4A2	1.52524154466482
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/481	49/9376	1.98905341762485	B4GALT1/COLGALT2/GALNT11/LFNG/GALNT3	1.61410580633673
Genetic Information Processing	Translation	hsa03010	Ribosome	16/481	222/9376	1.40488097244854	RPS3A/RPL12/RPL21/RPL27/RPS27L/RPL36AL/RPL22/RPS29/MRPL47/MRPL20/MRPL23/MRPL33/MRPL24/RPL23A/RPS17/MRPL51	1.41965756410346
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/481	36/9376	2.16585816585817	B4GALT5/GALNT11/GALNT3/ST3GAL1	1.62970399951247
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/481	23/9376	2.5425291512248	CTSA/MME/ATP6AP2	1.72229297925789
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/481	37/9376	2.10732145867281	CTNNB1/TPM3/BAX/MYC	1.56931306594816
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/481	128/9376	1.52286902286902	PDE4D/APRT/GUK1/NME2/PDE8A/NME1/ENTPD1/PDE4B/PDE9A/PDE3B	1.38503002258353
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/481	68/9376	1.71994619053443	PIK3R1/STAT3/ZBTB16/CSF2/ITGAM/MYC	1.38551587839839
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/481	216/9376	1.35366135366135	CALM1/PIK3R1/CDC42/HSP90B1/STAT3/NFE2L2/CYCS/RHOA/CALM3/HSPA8/BAX/MAP2K3/CYBA/LYN/EIF2AK3	1.22279018414859
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/481	168/9376	1.39233739233739	PIK3R1/MCL1/STAT3/CSF2/IFNGR1/PDGFRA/IRF9/IFNG/MYC/IL4R/IL21R/STAM	1.19321000696385
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/481	103/9376	1.51399794118241	PPP1CB/PPP2R2B/SAP18/PPP1CA/ALYREF/RBM8A/GSPT1/PABPN1	1.21970572437433
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/481	120/9376	1.46195426195426	CALM1/PIK3R1/CDC42/RHOA/ARHGDIB/CALM3/BAX/RPS6KA2/ARHGDIA	1.1843038155021
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/481	105/9376	1.48515988515989	CALM1/PIK3R1/FCER1G/RHOA/CALM3/CBLB/KSR1/IRF9	1.16252270497548
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/481	138/9376	1.41251619512489	CALM1/PIK3R1/PPP1CB/CALM3/PPP1CA/CBLB/FOXO1/INPP5A/PRKCI/PDE3B	1.13521146282227
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/481	89/9376	1.53313555560747	PLCL1/GNG2/GABARAP/GNB2/GNB1/GNG5/GABARAPL1	1.17511434524831
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/481	15/9376	2.5990297990298	ST3GAL5/ST3GAL1	1.44120667293714
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	10/481	140/9376	1.39233739233739	CALM1/GNA13/GNG2/CALM3/GNB2/GNB1/GNG5/PDE3B/SMAD3/JAG1	1.08759438590459
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/481	29/9376	2.01648863717829	CALM1/CALM3/GNB1	1.2748251009424
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/481	75/9376	1.55941787941788	IGF1/CYCS/CDK6/SIVA1/BAX/SHISA5	1.13106444959432
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/481	108/9376	1.44390544390544	SUMO2/SAP18/SUMO1/ALYREF/RAN/RBM8A/KPNA6/KPNA2	1.07893314887678
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/481	125/9376	1.40347609147609	PIK3R1/CTSD/PPP2R2B/GAB2/GNA13/FCER1G/RAC2/RHOA/BAX	1.0559993996944
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/481	142/9376	1.37272700652982	JUND/PIK3R1/FOSL2/GAB2/IFNGR1/CSF1/IRF9/CYBA/IFNG/FCGR3A	1.04069938676881
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/481	194/9376	1.30621342992477	MYL6/TUBA4A/ACTB/MYL12B/TPM3/KIF26B/MYO5B/CAPZA1/MYL12A/MYH9/MYO7A/TUBA1A/TPM4	1.00217059313924
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/481	16/9376	2.43659043659044	A4GALT/ST3GAL1	1.33733508395279
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/481	77/9376	1.51891351891352	PIK3R1/GAB2/CDK6/BAX/MYC/SMAD3	1.06318153212976
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/481	78/9376	1.49944026867104	BTG1/LSM7/ENO1/LSM4/LSM3/BTG2	1.0299621998131
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/481	78/9376	1.49944026867104	CFL1/ITGB2/CALM1/RHOA/ITGAM/CALM3	1.0299621998131
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/481	63/9376	1.54704154704155	POLR2K/POLR2L/RBX1/POLE4/POLR2E	1.01305024302536
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	22/481	362/9376	1.18464065425391	PIK3R1/MCL1/HSP90B1/YWHAZ/PPP2R2B/IGF1/ITGB7/F2R/GNG2/CDK6/COL1A1/PDGFRA/COL6A1/CSF1/GNB2/YWHAB/GNB1/MYC/GNG5/LAMA4/IL4R/COL4A2	0.833120918108401
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/481	184/9376	1.2712645756124	CFL1/PIK3R1/CDC42/CXCR4/MYL12B/RAC2/RHOA/SEMA4D/SLIT3/PARD6G/MYL12A/EPHA4	0.86413617630605
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/481	115/9376	1.3560155473199	JUND/PDE4D/BGLAP/GNA13/RHOA/GATA3/AKAP13/PDE4B	0.89325229856791
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/481	133/9376	1.31905647695121	CALM1/PPP1CB/PPP2R2B/GNG2/CALM3/PPP1CA/GNB2/GNB1/GNG5	0.861731779654301
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/481	99/9376	1.37827337827338	ACTB/EMD/IGF1/TPM3/ITGB7/LMNA/TPM4	0.879842218139896
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/481	169/9376	1.26875715041396	UBC/PIK3R1/HIF1A/CTSD/UBB/HMGB1/VAMP8/GABARAP/GABARAPL1/EIF2AK3/RAB1A	0.819840764296945
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/481	34/9376	1.71994619053443	POLR2K/POLR2L/POLR2E	0.977923235893393
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/481	34/9376	1.71994619053443	SKP1/RBX1/BHLHE40	0.977923235893393
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/481	100/9376	1.36449064449064	XCL1/XCL2/CXCR4/CCR9/TNFRSF1B/CCL4/CSF1	0.852101276294764
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/481	67/9376	1.45468085766593	CALM1/PPP1CB/CALM3/PPP1CA/RPS6KA2	0.868515866772939
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/481	119/9376	1.31043519278813	PIK3R1/CSF2/TNFAIP3/TNFRSF1B/CSF1/MAP2K3/MAP3K8/JAG1	0.792491291584616
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/481	122/9376	1.27821137657203	PIK3R1/CDC42/PPP2R2B/CSF2/RHOA/CBLB/MAP3K8/IFNG	0.719242352815079
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/481	70/9376	1.39233739233739	PIK3R1/CDC42/HIF1A/RBX1/ELOB	0.766147515045388
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	10/481	158/9376	1.23371667675465	YWHAZ/CDK6/SKP1/RBX1/ANAPC11/YWHAB/MYC/TFDP1/SMAD3/ANAPC16	0.688945859094605
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/481	105/9376	1.2995148995149	ACTB/EMD/IGF1/TPM3/ITGB7/LMNA/TPM4	0.71768685296348
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/481	71/9376	1.37272700652982	PIK3R1/HIF1A/LDHA/PDGFRA/MYC	0.733072701242989
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/481	106/9376	1.28725532499117	CTNNB1/PIK3R1/HSP90B1/IGF1/GSTP1/PDGFRA/FOXO1	0.691618105477426
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/481	89/9376	1.31411619052068	CD44/ITGB7/COL1A1/COL6A1/LAMA4/COL4A2	0.692361328508699
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/481	73/9376	1.33511804744681	PIK3R1/IGF1/CDK6/PDGFRA/BAX	0.668394606423312
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/481	73/9376	1.33511804744681	EML4/PIK3R1/STAT3/CDK6/BAX	0.668394606423312
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/481	91/9376	1.28523451600375	IFITM1/PIK3R1/CD81/RAC2/LYN/RASGRP3	0.635794871266193
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/481	163/9376	1.19587260691555	PIK3R1/YWHAZ/STAT3/CYCS/BAX/MAP2K3/YWHAB/MYC/SMAD3/IFIH1	0.586613657921682
NA	NA	hsa04519	Cadherin signaling	23/481	404/9376	1.10973425824911	CTNNB1/ARPC3/ACTB/KRT81/KRT86/CDC42/YWHAZ/PPP1CB/BRK1/ARPC5/RAC2/RHOA/PDGFRA/PPP1CA/VIM/ACTN1/ACTR3/MYO7A/MAP2K3/YWHAB/LHFPL3/KRT10/ACTN4	0.524292303784505
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/481	130/9376	1.19955221493683	COL3A1/PIK3R1/GNG2/COL1A1/GNB2/GNB1/GNG5/COL4A2	0.532765979270753
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/481	94/9376	1.24421639315256	JUND/HSP90B1/CSF2/TNFAIP3/IFNG/TRAF4	0.553354132652485
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/481	59/9376	1.32154057577786	CTNNB1/PIK3R1/BAX/MYC	0.576114682287361
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/481	298/9376	1.11200100461845	XCL1/XCL2/CXCR4/CCR9/TNFRSF18/TNFRSF4/CSF2/IFNGR1/TNFRSF1B/RELL1/CCL4/CSF1/BMP8A/CXCR6/IFNG/IL4R/IL21R	0.45689895126035
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/481	187/9376	1.14663079368962	TXN/RHOA/TNFAIP3/NAMPT/TRPV2/GABARAP/IRF9/CYBA/OAS1/GABARAPL1/OAS3	0.470974141364049
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/481	60/9376	1.2995148995149	PIK3R1/CDC42/RAC2/SH2D2A	0.541208385426189
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/481	133/9376	1.17249464617886	PIK3R1/STAT3/IGF1/FOXO1/GABARAP/PRMT1/GABARAPL1/SMAD3	0.465886541006575
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/481	226/9376	1.12126285577613	CALM1/PIK3R1/PPP1CB/PDE4D/TIAM1/ADORA2A/F2R/RAC2/RHOA/CALM3/PPP1CA/PDE4B/PDE3B	0.429098172099192
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/481	97/9376	1.20573547377671	CALM1/GNG2/CALM3/GNB2/GNB1/GNG5	0.473619593788602
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/481	79/9376	1.23371667675465	ATP6V0E1/ATP6V1G1/ATP6V0E2/ATP6V0B/ATP6V1F	0.485084092301094
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/481	80/9376	1.21829521829522	PIK3R1/STAT3/IGF1/PDGFRA/BAX	0.455959594596402
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/481	62/9376	1.25759506404668	PIK3R1/IGF1/HSPA8/FOXO1	0.473206242404013
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/481	44/9376	1.32904932904933	MPG/HMGB1/POLE4	0.508727462823368
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/481	99/9376	1.18137718137718	PIK3R1/HIF1A/RAC2/PDGFRA/PLPP1/PLPP3	0.421872938326447
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/481	83/9376	1.17426045136889	SKP1/FOXK2/CSNK2B/TFDP1/SCML1	0.370804599377428
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/481	83/9376	1.17426045136889	CCL4/POLR2K/ADAR/POLR2L/POLR2E	0.370804599377428
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/481	28/9376	1.39233739233739	B4GALT1/A4GALT	0.483464472337943
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/481	86/9376	1.13329787748392	CTNNB1/ACTB/EMD/ITGB7/LMNA	0.288768490702785
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/481	201/9376	1.06676596228835	ID2/GZMB/DDX5/IGF1/ITGB7/ZBTB16/CSF2/ITGAM/BAX/FOXO1/MYC	0.222502710173777
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/481	107/9376	1.09304991547982	CALM1/LDHA/CALM3/FOXO1/PRMT1/PDE3B	0.225100588763247
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/481	69/9376	1.13001295609991	CALM1/PPP1CB/CALM3/PPP1CA	0.252052797240208
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/481	50/9376	1.16956340956341	ITGB2/CD81/IFNG	0.279546872289692
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/481	109/9376	1.0729939537279	PIK3R1/PPP1CB/STAT3/PPP1CA/FOXO1/RPS6KA2	0.178244343062558
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/481	51/9376	1.14663079368962	PLAAT2/PLPP1/PLPP3	0.244158053144276
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/481	32/9376	1.21829521829522	GABARAP/GABARAPL1	0.287632527235093
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/481	32/9376	1.21829521829522	CYCS/BAX	0.287632527235093
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/481	13/9376	1.49944026867104	XRCC5	0.419018232117115
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	9/481	168/9376	1.04425304425304	STAT3/FTH1/HMGB1/EIF2AK2/TNFAIP3/IFNGR1/BAX/IRF9/IFNG	0.134586140073894
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/481	110/9376	1.06323946323946	PIK3R1/IGF1/ANAPC11/RPS6KA2/PDE3B/ANAPC16	0.155139922414216
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/481	52/9376	1.12458020150328	TSPO/APOC2/NPC2	0.209476239346028
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/481	170/9376	1.03196771432066	CTNNB1/ACTB/PIK3R1/NFE2L2/GSTP1/CDK6/BAX/MYC/SMAD3	0.0978105635306753
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/481	191/9376	1.02056143940961	CALM1/PPP1CB/ADORA2A/GNG2/CALM3/PPP1CA/GNB2/PKIA/GNB1/GNG5	0.0667599215676302
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/481	154/9376	1.01260901260901	CALM1/PPP1CB/PPP2R2B/TPM3/CREM/CALM3/PPP1CA/TPM4	0.0366871588940139
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/481	55/9376	1.06323946323946	B4GALT5/PLPP1/PLPP3	0.10937635997292
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/481	75/9376	1.03961191961192	PIK3R1/GSTP1/CYCS/BAX	0.080089742751612
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/481	36/9376	1.08292908292908	POLE4/SSBP1	0.115923070304137
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/481	178/9376	0.985587142890514	CTNNB1/RAC2/RHOA/SKP1/RBX1/CSNK2B/MYC/TLE3/SMAD3	-0.0451438484925259
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/481	158/9376	0.986973341403721	PIK3R1/IGF1/ATP6V1G1/RHOA/LAMTOR5/CAB39/ATP6V1F/RPS6KA2	-0.0383997523085048
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/481	98/9376	0.994526708812423	CALM1/PIK3R1/CALM3/SACM1L/INPP5A	-0.0126654203428164
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/481	37/9376	1.05366072933641	IFNG/LAMA4	0.0760488140244833
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/481	139/9376	0.981647945676723	CALM1/PIK3R1/HSP90B1/CTSD/CALM3/HSPA8/KRT10	-0.0506887772028266
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/481	300/9376	0.974636174636175	JUND/DUSP4/CDC42/IGF1/FLNA/RAC2/PDGFRA/HSPA8/CSF1/MAP2K3/MAP3K8/DUSP5/MYC/RPS6KA2/RASGRP3	-0.103827725016247
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/481	38/9376	1.0259328154065	PIK3R1/IGF1	0.0372477232951736
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/481	59/9376	0.991155431833398	PIK3R1/PLAAT2/PDE3B	-0.0158470997538771
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/481	17/9376	1.14663079368962	MYH9	0.140708431714066
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/481	60/9376	0.974636174636175	IGF1/GNA13/LYN	-0.0458311589694551
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/481	122/9376	0.958658532429024	CTNNB1/ACTB/PIK3R1/HIF1A/FOXO1/MYC	-0.106877492829191
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/481	82/9376	0.950864560620658	GSTP1/NME2/NME1/DUT	-0.103916769274313
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/481	144/9376	0.947562947562948	CTNNB1/ID2/PIK3R1/STAT3/IGF1/MYC/SMAD3	-0.147454088785702
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/481	103/9376	0.946248713239005	COL3A1/COL1A1/COL6A1/MME/COL4A2	-0.127550612370267
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/481	103/9376	0.946248713239005	PIK3R1/CALR/PPP2R2B/IFNGR1/IFNG	-0.127550612370267
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/481	62/9376	0.943196298035008	LFNG/TLE3/JAG1	-0.104349306773288
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/481	19/9376	1.0259328154065	HPSE2	0.0263113635026789
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/481	19/9376	1.0259328154065	DLST	0.0263113635026789
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/481	63/9376	0.928224928224928	COLGALT2/DLST/PHYKPL	-0.132918156396221
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/481	148/9376	0.921953138169354	CTNNB1/PIK3R1/IGF1/CDK6/BAX/MYC/JAG1	-0.22254493285726
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/481	42/9376	0.928224928224928	FTH1/PRNP	-0.108405067093349
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/481	43/9376	0.906638301987139	PLPP1/PLPP3	-0.1426847428486
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/481	65/9376	0.899664161202623	GPAT3/PLPP1/PLPP3	-0.188755580753347
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/481	109/9376	0.894161628106582	PIK3R1/CCL4/MAP2K3/MAP3K8/IRF9	-0.25844731111945
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/481	44/9376	0.886032886032886	ARHGDIB/ARHGDIA	-0.176199115498272
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/481	67/9376	0.872808514599559	LDHA/ENO1/PGK1	-0.242956837364518
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/481	154/9376	0.886032886032886	MYL6/ACTB/CALM1/PPP1CB/RHOA/CALM3/PPP1CA	-0.331598496127694
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/481	90/9376	0.866343266343266	PIK3R1/IGF1/BAX/FOXO1	-0.296266780943348
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/481	69/9376	0.847509717074934	CALM1/CALM3/PDE3B	-0.295629016647206
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/481	23/9376	0.847509717074934	B4GALT1	-0.170261251450809
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/481	23/9376	0.847509717074934	IDI1	-0.170261251450809
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/481	23/9376	0.847509717074934	SSBP1	-0.170261251450809
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/481	115/9376	0.847509717074934	PIK3R1/GNG2/GNB2/GNB1/GNG5	-0.382602099142859
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/481	93/9376	0.838396709364451	CALM1/CDC42/CALM3/MAP2K3	-0.364193926552667
NA	NA	hsa03272	Virion - Hepatitis viruses	2/481	48/9376	0.812196812196812	CD63/CD81	-0.30332940271275
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/481	116/9376	0.840203598824289	ENO1/PGK1/TALDO1/PGP/DLST	-0.402694497775799
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/481	72/9376	0.812196812196812	ISG15/ADAR/IFIH1	-0.371979971927408
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/481	26/9376	0.749720134335519	PLAAT2	-0.297161116847375
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/481	75/9376	0.77970893970894	ENO1/PGK1/TALDO1	-0.445397610669742
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/481	99/9376	0.787584787584788	PIK3R1/IGF1/BAX/JAG1	-0.494065621300453
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/481	166/9376	0.82198231595822	CALM1/PPP1CB/GNA13/RHOA/CALM3/PPP1CA/PDE3B	-0.538111874592025
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/481	76/9376	0.769449611554875	UBC/DBI/FABP5	-0.469263073037661
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/481	76/9376	0.769449611554875	ACTB/CALM1/CALM3	-0.469263073037661
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/481	122/9376	0.79888211035752	PIK3R1/PPP2R2B/IGF1/CAB39/FOXO1	-0.519937415651327
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/481	27/9376	0.721952721952722	FADS1	-0.336436534058054
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/481	104/9376	0.749720134335519	PLAAT2/GPAT3/PLPP1/PLPP3	-0.596816843713736
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/481	195/9376	0.799701476624554	ITGB2/ACTB/PIK3R1/HMGB1/RAC2/ITGAM/CYBA/FCGR3A	-0.65725705995595
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/481	105/9376	0.742579942579943	TNFAIP3/CCL4/CSNK2B/LYN	-0.616820703072533
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/481	30/9376	0.64975744975745	DLST	-0.446788355467145
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/481	30/9376	0.64975744975745	PLAAT2	-0.446788355467145
NA	NA	hsa04081	Hormone signaling	9/481	219/9376	0.801070828468089	PIK3R1/STAT3/IGF1/GNA13/GNG2/RHOA/GNB2/GNB1/GNG5	-0.692674379694654
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/481	31/9376	0.628797532023338	TALDO1	-0.48137912064485
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/481	31/9376	0.628797532023338	PGP	-0.48137912064485
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/481	32/9376	0.609147609147609	B4GALT1	-0.514999191620928
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/481	32/9376	0.609147609147609	LDHA	-0.514999191620928
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/481	33/9376	0.590688590688591	DLST	-0.547712744174122
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/481	33/9376	0.590688590688591	VAMP8	-0.547712744174122
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/481	86/9376	0.679978726490354	PIK3R1/CBLB/MYC	-0.693274805934615
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/481	183/9376	0.745623303000352	SBDS/RAN/PWP2/NHP2/CSNK2B/NOP10/SNU13	-0.808089453634868
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/481	88/9376	0.664524664524665	ITGB2/F2R/ITGAM	-0.735234755871182
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/481	63/9376	0.618816618816619	PLAAT2/LTC4S	-0.705902356107012
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/481	63/9376	0.618816618816619	CTNNB1/BAX	-0.705902356107012
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/481	89/9376	0.657058095260342	TUBA4A/PDGFRA/TUBA1A	-0.755897721710137
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/481	115/9376	0.678007773659948	GNG2/GNB2/GNB1/GNG5	-0.807886898379782
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/481	116/9376	0.672162879059431	GNG2/GNB2/GNB1/GNG5	-0.826165068788124
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/481	37/9376	0.526830364668203	FAH	-0.670583311937355
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/481	93/9376	0.628797532023338	CALM1/CALM3/LYZ	-0.836552794357038
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/481	38/9376	0.51296640770325	NAMPT	-0.699534246357882
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/481	217/9376	0.718625750883815	PIK3R1/HSP90B1/STAT3/MYC/KPNA6/RPS6KA2/KPNA2/JAG1	-0.975158895137156
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/481	122/9376	0.639105688286016	PIK3R1/STAT3/IGF1/MAP2K3	-0.932997338473462
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/481	70/9376	0.556934956934957	STAT3/TNFRSF1B	-0.86520731487109
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/481	41/9376	0.475432280310329	SSBP1	-0.782747211795971
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/481	41/9376	0.475432280310329	MYC	-0.782747211795971
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/481	98/9376	0.596716025287454	CALM1/CALM3/PRKD3	-0.933215661693556
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/481	71/9376	0.549090802611929	PIK3R1/STAT3	-0.886840013075715
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/481	150/9376	0.64975744975745	CTNNB1/PIK3R1/BAX/MYC/SMAD3	-1.0055253201774
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/481	42/9376	0.464112464112464	DLST	-0.809374659553515
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/481	101/9376	0.578991786912579	CTNNB1/CALM1/CALM3	-0.989189496206932
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/481	157/9376	0.620787372379729	DUSP4/CALR/HIF1A/ATP11B/DUSP5	-1.11423272522888
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/481	46/9376	0.423754858537467	FTH1	-0.911025578925123
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/481	78/9376	0.499813422890346	SACM1L/INPP5A	-1.03150126169776
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/481	47/9376	0.414738797717521	LDHA	-0.935333130376497
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/481	47/9376	0.414738797717521	PIK3R1	-0.935333130376497
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/481	48/9376	0.406098406098406	PIK3R1	-0.959237262453235
NA	NA	hsa04382	Cornified envelope formation	7/481	217/9376	0.628797532023338	S100A4/S100A6/KRT81/KRT86/PPP2R2B/KRT10/COL4A2	-1.2864766043137
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/481	52/9376	0.374860067167759	IGF1	-1.05114585314971
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/481	54/9376	0.360976360976361	LDHA	-1.09507648892277
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/481	144/9376	0.541464541464541	CTNNB1/TRA2A/FOXO1/MAP2K3	-1.28941130502034
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/481	57/9376	0.3419776051355	FADS1	-1.15872038279946
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/481	59/9376	0.330385143944466	GSTP1	-1.19977066383635
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/481	154/9376	0.506304506304506	NME2/NME1/CTPS1/CMPK2	-1.43645546119282
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/481	61/9376	0.319552844143008	FTH1	-1.23980416564027
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/481	65/9376	0.299888053734208	PDE8A	-1.31707711415684
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/481	65/9376	0.299888053734208	PIK3R1	-1.31707711415684
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/481	68/9376	0.286657698422404	ALDH1A3	-1.37280688274126
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/481	323/9376	0.603489891415588	CD44/PIK3R1/MCL1/STAT3/RHOA/CDK6/PDGFRA/VIM/ZEB2/MYC	-1.68633737203932
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/481	70/9376	0.278467478467478	GSTP1	-1.40899225817658
NA	NA	hsa04082	Neuroactive ligand signaling	5/481	199/9376	0.489766921927726	ADORA2A/GNG2/GNB2/GNB1/GNG5	-1.69172583929105
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/481	254/9376	0.537201041138049	CALM1/CXCR4/ADORA2A/F2R/MCOLN2/CALM3/PDGFRA	-1.73879906426148
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/481	73/9376	0.267023609489363	GSTP1	-1.46192504338547
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/481	75/9376	0.25990297990298	HSP90B1	-1.49637231751245
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/481	79/9376	0.24674333535093	GSTP1	-1.56340074022455
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/481	117/9376	0.333208948593564	ACTB/CDK2AP2	-1.68766347676966
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/481	83/9376	0.234852090273777	PRDX5	-1.62813972936356
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/481	155/9376	0.377278519214003	CTNNB1/CDK6/PDE8A	-1.81784096170266
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/481	102/9376	0.191105132281603	RHOA	-1.91004597193312
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/481	370/9376	0.474147328201382	TSPO/GZMA/ADORA2A/F2R/GPR35/NR3C1/PGRMC2/P2RY8/CALCRL	-2.3998504326807
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/481	449/9376	0.130240914205279	CALM1/CALM3/GNB1	-4.39192158565024