category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	40/478	205/9376	3.8273293193183	CD44/PIK3R1/ISG15/TNFAIP3/HLA-DRB5/HLA-DRB1/PLCG2/HLA-DRA/VIM/HLA-C/CYCS/CD247/BAX/CALR/LYN/NFKB1/TAB2/PSMD8/MAP2K3/CDK6/RELB/HLA-DPB1/PDIA3/HLA-DPA1/JAK1/CD58/STAT3/HLA-A/PSMC4/EIF2AK2/PSMD7/HLA-DQA2/PSMD14/CCND2/MYC/MAPK8/IRF9/FAS/HLA-DQA1/HLA-G	9.4863330164477
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	42/478	232/9376	3.55100274130717	CXCR4/PIK3R1/TMSB4X/MYH9/ITGB2/ARPC3/EZR/ITGAE/GNA13/PPP1CB/MSN/PFN1/MYL12B/ITGA4/ACTB/CDC42/CFL1/F2R/IQGAP2/BRAF/ROCK1/ARPC2/SSH1/ARHGEF7/TIAM1/PAK1/PAK2/SOS2/DIAPH1/BRK1/RGCC/GIT1/ACTN1/ARPC5/PDGFRA/RHOA/ACTR2/ITGB7/ACTR3/NCKAP1L/GNA12/ITGAV	9.11885258240211
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/478	268/9376	3.14719290576407	PSMA7/ATP5F1E/TUBA4A/UBC/NFE2L2/NDUFB2/MT-CO3/NDUFA13/CYCS/BAX/COX6C/CALM1/COX7A2/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/PSMB1/PSMB6/PARK7/EIF2AK3/MAP3K5/MT-ND6/CALM3/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/ITPR3/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/UQCRFS1/ADORA2A/PSMA1/TXN/COX6A1/NDUFA11/PSMB7	8.26571326072701
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/478	200/9376	3.53071129707113	WIPF3/FYN/MYH9/MYO5B/ARPC3/TUBA4A/EZR/GNA13/CYTH3/ACTB/CDC42/ARF6/F2R/CYCS/BAX/SEC24B/NFKB1/ROCK1/ARPC2/TAB2/SEC24A/PAK1/PAK2/CYTH1/RAB1A/BRK1/ARPC5/MAPK8/RHOA/FAS/ACTR2/TMBIM6/ACTR3/NCKAP1L/GNA12/ABL1	8.38463738081746
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	17/478	46/9376	7.24904493360015	PSME2/PSMA7/PSME4/POMP/PSME1/PSMA6/PSMD8/PSMB1/PSMB6/PSMC4/PSMB9/PSMD7/PSMB3/PSMA2/PSMD14/PSMA1/PSMB7	9.84702696592657
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	51/478	368/9376	2.71839185010005	TNFRSF1B/PSMA7/ATP5F1E/TUBA4A/PFN1/NDUFB2/HNRNPA3/ACTB/NUP98/MT-CO3/DCTN6/NDUFA13/CYCS/BAX/COX6C/SRSF7/COX7A2/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/MAP2K3/PSMB1/PSMB6/RAB1A/VCP/EIF2AK3/ATG2A/MAP3K5/MT-ND6/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/MAP1LC3A/ANXA11/ITPR3/NDUFB6/UQCRQ/NDUFA6/NDUFC2/DCTN5/UQCRFS1/PSMA1/COX6A1/NDUFA11/NUP58/ALYREF/PSMB7	7.79444704202082
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	39/478	248/9376	3.08462680523687	ARPC3/FLNA/TUBA4A/CYTH3/CTNNB1/PFN1/MYL12B/SNX9/ACTB/CDC42/DCTN6/ARF6/CYCS/HSP90B1/BAX/PTPRC/NFKB1/ARPC2/TAB2/PAK1/MAP2K3/CYTH1/RALA/KPNA1/BRK1/BIRC2/MYC/ARPC5/MAPK8/RHOA/SKP1/DCTN5/DYNLT1/ACTR2/TXN/PLEKHM2/S100A10/ACTR3/NCKAP1L	7.71116024687682
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	34/478	214/9376	3.11641184061315	CXCR4/PIK3R1/GNG2/TNFRSF1B/PLCG2/CFL1/APOBEC3G/HLA-C/CYCS/CD247/BAX/CALR/CALM1/NFKB1/TAB2/AP1S1/PAK1/PAK2/MAP2K3/PDIA3/CCR5/BST2/HLA-A/PTK2B/CALM3/GNG4/RNF7/PRKCA/ITPR3/MAPK8/SKP1/FAS/HLA-G/RBX1	7.25880803606504
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/478	109/9376	4.13895819738206	IRF4/HLA-DRB5/HLA-DRB1/SMAD3/IFNGR1/HLA-DRA/TGFBR2/CD247/NFKB1/IL21R/PRKCQ/TGFB1/HLA-DPB1/HIF1A/HLA-DPA1/AHR/JAK1/STAT3/HLA-DQA2/IL4R/MAPK8/HLA-DQA1/SMAD4	7.63981048236524
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	30/478	180/9376	3.26917712691771	PIK3R1/PPP1CB/HLA-DRB5/SRSF2/HLA-DRB1/IFNGR1/HLA-DRA/HLA-C/CYCS/BAX/CALR/SRSF7/CD74/NFKB1/TAB2/SRSF5/HLA-DPB1/PDIA3/HLA-DPA1/JAK1/BST2/BIRC2/HLA-A/EIF2AK2/HLA-DQA2/IRF9/FAS/HLA-DQA1/HLA-G/ALYREF	7.12456830184963
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/478	227/9376	2.93793891582032	CXCR4/PIK3R1/GNG2/AKAP13/GNA13/CTNNB1/PTGER4/HLA-C/CYCS/BAX/CALR/ADCY3/CALM1/NFKB1/ROCK1/CDK6/SOS2/PDIA3/CCR5/JAK1/STAT3/HLA-A/PTK2B/CALM3/GNG4/PRKCA/ITPR3/MYC/PDGFRA/RHOA/FAS/HLA-G/GNA12/ITGAV	6.85045762882414
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	36/478	250/9376	2.8245690376569	CXCR4/WIPF3/ARPC3/CBLB/CYTH3/VPS37B/ASAP1/ARF5/SMAD3/CDC42/GRK5/ARF6/BIN1/CAPZA1/TGFBR2/HLA-C/EPS15/ARPC2/ITCH/CYTH1/CCR5/HLA-A/STAM/GIT1/CHMP4A/SPART/CHMP4B/ARPC5/PDGFRA/RHOA/PARD6G/SNF8/ACTR2/HLA-G/ACTR3/SH3KBP1	6.77709320752765
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/478	196/9376	3.10238237554436	PIK3R1/GNG2/CLEC2B/UBC/CTNNB1/PLCG2/IFNGR1/HLA-C/CYCS/BAX/CALM1/LYN/NFKB1/CDK6/CREBBP/HIF1A/CCR5/JAK1/STAT3/HLA-A/CALM3/GNG4/EIF2AK2/MAP1LC3A/ITPR3/MYC/MAPK8/IRF9/FAS/PREX1/HLA-G	6.89400807943521
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	38/478	275/9376	2.71044503613541	PIK3R1/PSMA7/FYN/ATP5F1E/TUBA4A/CYBA/NDUFB2/MT-CO3/NDUFA13/CYCS/BAX/COX6C/COX7A2/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/PSMB1/PSMB6/EIF2AK3/MT-ND6/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/ITPR3/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/UQCRFS1/PSMA1/COX6A1/NDUFA11/PSMB7	6.67243418234525
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	54/478	480/9376	2.20669456066946	TNFRSF1B/PSMA7/ATP5F1E/TUBA4A/UBC/CTNNB1/NDUFB2/ATXN1/MT-CO3/DCTN6/NDUFA13/CYCS/BAX/COX6C/CALM1/COX7A2/BRAF/NFKB1/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/MAP2K3/PSMB1/PSMB6/RAB1A/VCP/PARK7/EIF2AK3/ATG2A/MAP3K5/MT-ND6/CALM3/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/MAP1LC3A/PRKCA/ITPR3/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/DCTN5/UQCRFS1/FAS/PSMA1/COX6A1/NDUFA11/PSMB7	6.29033786041402
NA	NA	hsa04517	IgSF CAM signaling	39/478	299/9376	2.55848644715299	PIK3R1/MYL6/FYN/MYH9/ITGB2/ARPC3/TUBA4A/EZR/MSN/CTNNB1/FOXO1/MYL12B/ITGA4/ACTB/PLCG2/SH2D1A/CDC42/ARF6/SPTBN1/TIGIT/LYN/ARPC2/PRKCQ/PAK1/PAK2/EPB41L3/RASA1/GIT1/ACTN1/PRKCA/ARPC5/MAPK8/RHOA/PARD6G/ACTR2/CRTAM/SH2D1B/ACTR3/ABL1	6.34776502584964
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/478	157/9376	3.24835434266983	PIK3R1/NDUFB2/CDC42/MT-CO3/NDUFA13/CYCS/BAX/COX6C/COX7A2/NFKB1/UQCRB/NDUFA4/ITCH/NDUFS6/TGFB1/EIF2AK3/MAP3K5/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/UQCRFS1/FAS/COX6A1/NDUFA11	6.58454942634876
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	39/478	308/9376	2.48372547954138	PSMA7/ATP5F1E/TUBA4A/NDUFB2/MT-CO3/DCTN6/NDUFA13/CYCS/BAX/COX6C/COX7A2/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/PSMB1/PSMB6/CREBBP/ATG2A/MAP3K5/MT-ND6/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/NDUFB6/POLR2K/UQCRQ/NDUFA6/NDUFC2/MAPK8/DCTN5/UQCRFS1/PSMA1/COX6A1/NDUFA11/PSMB7	6.13658201732981
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	45/478	388/9376	2.27494284605099	PIK3R1/PSMA7/ATP5F1E/TUBA4A/CTNNB1/NDUFB2/MT-CO3/NDUFA13/CYCS/COX6C/CALM1/COX7A2/BRAF/NFKB1/UQCRB/PSMA6/NDUFA4/NDUFS6/PSMD8/PSMB1/PSMB6/EIF2AK3/ATG2A/MAP3K5/MT-ND6/CALM3/PSMC4/EIF2AK2/PSMD7/PSMB3/PSMA2/PSMD14/ITPR3/NDUFB6/UQCRQ/NDUFA6/MME/NDUFC2/MAPK8/UQCRFS1/FAS/PSMA1/COX6A1/NDUFA11/PSMB7	5.9446793352134
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/478	173/9376	3.06131037318306	PIK3R1/HLA-DRB5/ACTB/HLA-DRB1/NUP98/IFNGR1/HLA-DRA/CYCS/BAX/NFKB1/KPNA2/KPNA6/CDK6/HLA-DPB1/CREBBP/KPNA1/MX1/HLA-DPA1/JAK1/EIF2AK2/HLA-DQA2/PRKCA/PABPN1/IRF9/FAS/HLA-DQA1/HNRNPUL1	6.34242171107679
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/478	253/9376	2.63601633949096	CD44/PIK3R1/FNBP1/ARPC3/UBC/CYTH3/PFN1/FOXO1/MYL12B/ACTB/PLCG2/CDC42/ARF6/FOXO3/CYCS/BAX/NFKB1/ROCK1/ARPC2/TAB2/PRKCQ/CYTH1/DIAPH1/GLMN/ACTN1/MAP1LC3A/ITPR3/ARPC5/MAPK8/RHOA/SKP1/ACTR2/ACTR3/RBX1	6.11409870704095
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/478	203/9376	2.80215182307232	PIK3R1/FYN/FLNA/PPP1CB/CTNNB1/MYL12B/ITGA4/ACTB/CDC42/IGF1/BRAF/ROCK1/COL1A1/PAK1/PAK2/SOS2/DIAPH1/BIRC2/COL6A1/ACTN1/PRKCA/CCND2/PARVB/PDGFRA/MAPK8/RHOA/COL6A3/ITGB7/ITGAV	6.01640527712902
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	31/478	227/9376	2.67870901148324	PIK3R1/ATP5F1E/CYBA/NFE2L2/NDUFB2/PTPRJ/MT-CO3/FOXO3/NDUFA13/COX6C/COX7A2/BRAF/NFKB1/UQCRB/NDUFA4/NDUFS6/SOS2/HIF1A/AHR/MAP3K5/MT-ND6/PRKD3/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/UQCRFS1/COX6A1/NDUFA11/ABL1	5.93410084312347
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/478	66/9376	4.45796880943325	IL12RB2/HLA-DRB5/HLA-DRB1/SMAD3/IFNGR1/HLA-DRA/NFKB1/IL21R/TGFB1/HLA-DPB1/HLA-DPA1/STAT3/HLA-DQA2/IL4R/HLA-DQA1	6.53388647974579
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/478	204/9376	2.69226351628518	CD44/PIK3R1/FLNA/EZR/PPP1CB/MSN/CTNNB1/ACTB/PLCG2/CDC42/CD63/IGF1/BRAF/ROCK1/COL1A1/TIAM1/PAK1/TGFB1/DDX5/SOS2/HIF1A/STAT3/PRKCA/ITPR3/MYC/RHOA/FAS/ITGAV	5.66375473183174
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	28/478	205/9376	2.67913052352281	PIK3R1/ATP5F1E/COL3A1/PPP1CB/CYBA/NDUFB2/SMAD3/MT-CO3/TGFBR2/NDUFA13/COX6C/COX7A2/NFKB1/UQCRB/COL1A1/NDUFA4/NDUFS6/TGFB1/MT-ND6/PRKCA/NDUFB6/UQCRQ/NDUFA6/NDUFC2/MAPK8/UQCRFS1/COX6A1/NDUFA11	5.63386486865285
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/478	70/9376	4.20322773460849	FYN/ITGB2/HLA-DRB5/ACTB/HLA-DRB1/HLA-DRA/HLA-C/CYCS/HLA-DPB1/HLA-DPA1/HLA-A/HLA-DQA2/HLA-DQA1/HLA-G/ABL1	6.23460147266213
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/478	39/9376	5.53245359939921	HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-C/HLA-DPB1/HLA-DPA1/HLA-A/HLA-DQA2/FAS/HLA-DQA1/HLA-G	6.57378319206145
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/478	50/9376	4.70761506276151	CXCR4/CCR9/HLA-DRB5/ITGA4/HLA-DRB1/HLA-DRA/TGFB1/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DQA1/ITGB7	6.09235666452138
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/478	78/9376	3.77212745413582	ITGB2/CYBA/HLA-DRB5/ITGA4/HLA-DRB1/IFNGR1/HLA-DRA/NFKB1/TAB2/TGFB1/HLA-DPB1/HLA-DPA1/JAK1/HLA-DQA2/HLA-DQA1	5.69795624820022
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/478	98/9376	3.40261292801639	PIK3R1/ARPC3/ASAP1/GAB2/PLCG2/CDC42/CFL1/ARF6/BIN1/PTPRC/LYN/ARPC2/PAK1/PRKCA/ARPC5/ACTR2/ACTR3	5.54144528107654
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/478	44/9376	4.90376569037657	HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-C/HLA-DPB1/HLA-DPA1/HLA-A/HLA-DQA2/FAS/HLA-DQA1/HLA-G	6.01556053906286
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/478	224/9376	2.45188284518828	PIK3R1/ITGB2/HLA-DRB5/ETS1/HLA-DRB1/SMAD3/HLA-DRA/TGFBR2/HLA-C/BAX/CALR/ADCY3/NFKB1/TSPO/TGFB1/RELB/HLA-DPB1/CREBBP/HLA-DPA1/JAK1/HLA-A/HLA-DQA2/CCND2/MYC/MAPK8/HLA-DQA1/SMAD4/HLA-G	5.09742639084044
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/478	45/9376	4.79479311947931	HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-C/HLA-DPB1/HLA-DPA1/HLA-A/HLA-DQA2/FAS/HLA-DQA1/HLA-G	5.91403175950935
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	21/478	144/9376	2.860529986053	PIK3R1/PSMA7/ATXN1/CYCS/PSMA6/PSMD8/PUM1/PSMB1/PSMB6/ATG2A/MAP3K5/PSMC4/PSMD7/PSMB3/PSMA2/PSMD14/PRKCA/ITPR3/MAPK8/PSMA1/PSMB7	5.21462890764656
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/478	112/9376	3.15242080095637	HLA-DRB5/HLA-DRB1/IFNGR1/HLA-DRA/CYCS/NFKB1/TAB2/TGFB1/MAP2K3/HLA-DPB1/HLA-DPA1/CCR5/JAK1/STAT3/BIRC2/HLA-DQA2/MAPK8/HLA-DQA1	5.31117124504154
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	12/478	54/9376	4.35890283589028	HLA-DRB5/HLA-DRB1/HLA-DRA/TG/HLA-C/HLA-DPB1/HLA-DPA1/HLA-A/HLA-DQA2/FAS/HLA-DQA1/HLA-G	5.73710974349732
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/478	82/9376	3.5881212368609	PSME2/HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-C/CALR/PSME1/CD74/HLA-DPB1/PDIA3/HLA-DPA1/HLA-A/HLA-DQA2/HLA-DQA1/HLA-G	5.4556134864546
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/478	138/9376	2.84276271905888	PIK3R1/WIPF3/ARPC3/ITGA4/RPS6KA3/ACTB/CDC42/ARF6/NFKB1/ROCK1/ARPC2/TAB2/ARHGEF7/MAP2K3/PTK2B/ARPC5/MAPK8/RHOA/ACTR2/ACTR3	5.05444374743308
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/478	116/9376	3.04371663540615	CXCR4/PIK3R1/ITGB2/EZR/MSN/CTNNB1/CYBA/MYL12B/ITGA4/ACTB/PLCG2/CDC42/ROCK1/PTK2B/ACTN1/PRKCA/RHOA/ITK	5.13331088690845
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/478	163/9376	2.64743178376158	PIK3R1/YWHAZ/SMAD3/TGFBR2/CYCS/BAX/BRAF/NFKB1/TAB2/TGFB1/MAP2K3/CREBBP/SOS2/JAK1/STAT3/PTK2B/YWHAB/PRKCA/MYC/MAPK8/FAS/SMAD4	4.91761010984135
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/478	77/9376	3.5663750475466	PIK3R1/SMAD3/CDC42/TGFBR2/BAX/BRAF/NFKB1/TGFB1/CDK6/RALA/JAK1/STAT3/MAPK8/SMAD4	5.24083815909445
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	24/478	193/9376	2.4391787889956	CXCR4/PIK3R1/GNG2/CCR9/PLCG2/CDC42/GRK5/FOXO3/ADCY3/LYN/BRAF/NFKB1/ROCK1/TIAM1/PAK1/CXCR6/SOS2/CCR5/STAT3/PTK2B/GNG4/RHOA/PREX1/ITK	4.68224891602882
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	16/478	101/9376	3.1073366750901	PIK3R1/COL3A1/FOXO1/SMAD3/PLCG2/CDC42/TGFBR2/BAX/NFKB1/COL1A1/TGFB1/DIAPH1/STAT3/PRKCA/MAPK8/SMAD4	4.93504411257598
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/478	170/9376	2.53841988678317	MYL6/MYH9/ARPC3/TUBA4A/EZR/MSN/MYL12B/ACTB/CDC42/ROCK1/ARPC2/RAB8B/TIAM1/MAP3K5/PPP2CA/ACTN1/ARPC5/MAPK8/RHOA/PARD6G/ACTR2/ACTR3	4.69155969364471
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/478	235/9376	2.25364550876881	ATP5F1E/BMP8A/NDUFB2/RPS6KA3/ACTB/MT-CO3/NDUFA13/ADCY3/COX6C/COX7A2/UQCRB/NDUFA4/NDUFS6/MAP2K3/SOS2/MAP3K5/MT-ND6/NDUFAF8/NDUFB6/COX20/UQCRQ/NDUFA6/NDUFC2/UQCRFS1/SMARCC1/COX6A1/NDUFA11	4.51092089880031
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/478	93/9376	3.16371980024295	IL12RB2/HLA-DRB5/HLA-DRB1/IFNGR1/HLA-DRA/CD247/NFKB1/PRKCQ/HLA-DPB1/HLA-DPA1/JAK1/HLA-DQA2/IL4R/MAPK8/HLA-DQA1	4.86017272853526
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	19/478	138/9376	2.70062458310594	ATP5F1E/NDUFB2/MT-CO3/NDUFA13/CYCS/COX6C/COX7A2/UQCRB/NDUFA4/NDUFS6/MT-ND6/PPA1/NDUFB6/UQCRQ/NDUFA6/NDUFC2/UQCRFS1/COX6A1/NDUFA11	4.66457846249501
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/478	174/9376	2.48006540662723	NFE2L2/STT3B/HSP90B1/BAX/CALR/MAN1A1/SEC24B/SEC24A/PDIA3/PLAA/SEC61B/VCP/EIF2AK3/MAP3K5/SEC61G/SELENOS/MAPK8/SKP1/RPN2/BCAP31/RAD23B/RBX1	4.56738691662289
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	27/478	238/9376	2.22523821243979	PIK3R1/GNG2/ETS1/GAB2/PLCG2/STK4/CDC42/ARF6/PLAAT2/CALM1/RALGAPA1/IGF1/NFKB1/TIAM1/PAK1/PAK2/RALA/SOS2/REL/CALM3/GNG4/RASA1/PRKCA/PDGFRA/MAPK8/RHOA/ABL1	4.43748420776932
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/478	87/9376	3.15644688116193	PIK3R1/CTNNB1/SMAD3/TGFBR2/CYCS/BAX/BRAF/TGFB1/RALA/SOS2/MYC/MAPK8/RHOA/SMAD4	4.68346517729223
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/478	77/9376	3.31163397272184	PIK3R1/SMAD3/GAB2/TGFBR2/BAX/BRAF/NFKB1/TGFB1/CDK6/SOS2/MYC/SMAD4/ABL1	4.72062707501825
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/478	110/9376	2.85310003803728	BMP8A/SMAD3/TGFBR2/ROCK1/ACVR1B/NBL1/TGFB1/CREBBP/SKI/PPP2CA/TGIF1/MYC/RHOA/SKP1/SMAD4/RBX1	4.53108746327666
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/478	133/9376	2.65467014817378	PIK3R1/FYN/ITGB2/PLCG2/SH2D1A/IFNGR1/HLA-C/CD247/BRAF/PAK1/SOS2/HLA-A/PTK2B/HCST/PRKCA/FAS/SH2D1B/HLA-G	4.45434818435133
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/478	157/9376	2.49873410974602	PIK3R1/PPP1CB/FOXO1/ETS1/SMAD3/FOXO3/ZFP36L2/TGFBR2/HLA-C/CALM1/NFKB1/TGFB1/MAP2K3/CDK6/HLA-A/CALM3/CCND2/ITPR3/MYC/HLA-G	4.38920531132075
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/478	73/9376	3.22439387860377	CXCR4/ELL2/APOBEC3G/FEZ1/CREBBP/MX1/CCR5/BST2/CHMP4A/CPSF6/CHMP4B/CCNT2	4.42196190301025
NA	NA	hsa04518	Integrin signaling	19/478	154/9376	2.42004021083519	PIK3R1/ITGB2/FLNA/ITGAE/CTNNB1/ITGA4/ACTB/CDC42/IGF1/COL1A1/TGFB1/COL6A1/ACTN1/CCND2/PARVB/PDGFRA/COL6A3/ITGB7/ITGAV	4.11814685421182
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/478	300/9376	1.96150627615063	JUND/DUSP4/FLNA/RPS6KA3/STK4/CDC42/DUSP16/TGFBR2/PPM1B/IGF1/BRAF/NFKB1/TAB2/PAK1/PAK2/TGFB1/MAP2K3/RELB/SOS2/MAP3K5/DUSP8/RASA1/MAP3K13/PRKCA/MYC/PDGFRA/MAP4K4/MAPK8/FAS/GNA12	3.92300528277814
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	16/478	120/9376	2.61534170153417	PIK3R1/ARHGDIB/RPS6KA3/PLCG2/CDC42/FOXO3/BAX/CALM1/BRAF/NFKB1/SOS2/MAP3K5/CALM3/MAPK8/RHOA/ABL1	4.12759179792604
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/478	333/9376	1.88493095606066	PIK3R1/ISG15/CTNNB1/FOXO1/ITGA4/HES4/CDC42/PTGER4/HLA-C/BAX/NFKB1/COL1A1/CDK6/UBR4/CREBBP/SOS2/MX1/LFNG/JAK1/HLA-A/COL6A1/EIF2AK2/PPP2CA/CCND2/PARD6G/IRF9/FAS/COL6A3/BCAP31/ITGB7/HLA-G/ITGAV	3.81090940576393
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/478	133/9376	2.50718847327524	PIK3R1/FOXO1/SMAD3/STK4/GABARAPL1/FOXO3/TGFBR2/IGF1/BRAF/TGFB1/CREBBP/SOS2/STAT3/CCND2/MAPK8/PRMT1/SMAD4	4.05732964169226
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/478	99/9376	2.77384725920291	PRKCH/PIK3R1/PPP1CB/PLCG2/PTGER4/ADCY3/CALM1/IGF1/PRKCQ/MAP2K3/CALM3/PRKCA/ITPR3/MAPK8	4.11228708761662
Human Diseases	Infectious disease: viral	hsa05162	Measles	17/478	136/9376	2.45188284518828	PIK3R1/CBLB/MSN/TNFAIP3/CYCS/BAX/NFKB1/TAB2/CDK6/MX1/JAK1/STAT3/EIF2AK2/CCND2/MAPK8/IRF9/FAS	3.95292366922802
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/478	149/9376	2.36960489736317	PIK3R1/FYN/GNA13/CYTH3/GAB2/PLCG2/ARF6/F2R/ADCY3/CYTH1/RALA/SOS2/AGPAT4/PTK2B/PRKCA/PDGFRA/RHOA/GNA12	3.9058140197363
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/478	137/9376	2.43398589011392	PIK3R1/MCL1/TUBA4A/ACTB/CYCS/BAX/LMNA/NFKB1/CTSW/LMNB1/BCL2A1/EIF2AK3/BIRC2/MAP3K5/ITPR3/MAPK8/FAS	3.91873651662572
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/478	80/9376	2.94225941422594	PIK3R1/PLCG2/FOXO3/BAX/IGF1/BRAF/SOS2/JAK1/STAT3/PRKCA/EIF4E/PDGFRA	4.04350101948059
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	22/478	205/9376	2.10503112562506	PIK3R1/YWHAZ/CDC42/HLA-C/BAX/LYN/NFKB1/CDK6/UBR4/CREBBP/REL/CCR5/JAK1/STAT3/HLA-A/YWHAB/EIF2AK2/ACTN1/CCND2/RHOA/IRF9/HLA-G	3.70763079475542
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/478	70/9376	3.08236700537956	PIK3R1/ETS1/CDC42/BRAF/PAK1/PAK2/TGFB1/CREBBP/SOS2/HIF1A/RBX1	4.05301448226541
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/478	93/9376	2.74189049354389	FYN/CTNNB1/MYL12B/PTPRJ/ACTB/SMAD3/CDC42/TGFBR2/ROCK1/CREBBP/ACTN1/RHOA/SMAD4	3.91265480487181
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/478	142/9376	2.34828216158878	JUND/FOSL2/PIK3R1/FYN/CYBA/GAB2/PLCG2/IFNGR1/TGFBR2/NFKB1/TAB2/TGFB1/RELB/JAK1/ITPR3/MAPK8/IRF9	3.75217781666101
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/478	181/9376	2.1674102498902	ITGB2/HLA-DRB5/HLA-DRB1/IFNGR1/HLA-DRA/CYCS/BAX/CALM1/CD74/NFKB1/TGFB1/HLA-DPB1/CREBBP/HLA-DPA1/JAK1/CALM3/HLA-DQA2/MAPK8/RHOA/HLA-DQA1	3.67570211804558
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/478	155/9376	2.27787825617492	ITGB2/TUBA4A/CYBA/HLA-DRB5/ACTB/HLA-DRB1/HLA-DRA/HLA-C/CALR/HLA-DPB1/SEC61B/HLA-DPA1/HLA-A/SEC61G/HLA-DQA2/HLA-DQA1/HLA-G/ITGAV	3.71808834103275
Human Diseases	Immune disease	hsa05310	Asthma	7/478	32/9376	4.2907949790795	HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DQA1	4.32178130079381
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/478	156/9376	2.26327647248149	PIK3R1/CTNNB1/YWHAZ/CYCS/BAX/BRAF/NFKB1/CDK6/SOS2/MX1/JAK1/STAT3/YWHAB/EIF2AK2/PPP2CA/MYC/IRF9/FAS	3.68764097762304
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/478	73/9376	2.95569438872012	EML4/PIK3R1/PLCG2/STK4/FOXO3/BAX/BRAF/CDK6/SOS2/STAT3/PRKCA	3.88780339850583
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/478	158/9376	2.23462740320958	YWHAZ/SMAD3/CCNH/RAD21/NIPBL/TGFB1/CDK6/CREBBP/MCM6/YWHAB/STAG2/PPP2CA/CCND2/MYC/SKP1/SMAD4/ABL1/RBX1	3.62743375096696
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	22/478	212/9376	2.03552538091103	PIK3R1/ITGB2/CTNNB1/SIPA1L1/PFN1/ACTB/CDC42/F2R/ADCY3/CALM1/IGF1/BRAF/TIAM1/MAP2K3/RALA/CALM3/PRKD3/PRKCA/PDGFRA/RHOA/PARD6G/ADORA2A	3.53459390313592
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/478	134/9376	2.34209704615	PRKCH/MYL6/MYH9/GNA13/PPP1CB/ADCY3/CALM1/BRAF/ROCK1/PRKCQ/CALM3/PRKCA/ITPR3/RHOA/ADORA2A/GNA12	3.62665900710192
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	15/478	122/9376	2.41168804444749	PIK3R1/FYN/CBLB/CDC42/CD247/PTPRC/NFKB1/PRKCQ/PAK1/PAK2/SOS2/PPP2CA/MAPK8/RHOA/ITK	3.63753591716232
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/478	76/9376	2.83902224179696	PIK3R1/PLCG2/BAX/CALM1/IGF1/BRAF/CDK6/SOS2/CALM3/PRKCA/PDGFRA	3.73083196838932
Organismal Systems	Immune system	hsa04611	Platelet activation	15/478	126/9376	2.33512651922694	PIK3R1/FYN/COL3A1/GNA13/PPP1CB/MYL12B/ACTB/PLCG2/F2R/ADCY3/LYN/ROCK1/COL1A1/ITPR3/RHOA	3.49695637324421
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/478	69/9376	2.84276271905888	ALOX5AP/PIK3R1/FYN/GAB2/PLCG2/LYN/MAP2K3/SOS2/PRKCA/MAPK8	3.56075827033177
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/478	157/9376	2.12392399328412	ITGB2/PPP1CB/CTNNB1/BMP8A/YWHAZ/ACTB/SMAD3/TGFBR2/TGFB1/BIRC2/YWHAB/PPP2CA/CCND2/MYC/PARD6G/CSNK1D/SMAD4	3.29153325380675
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/478	160/9376	2.08410041841004	ITGB2/HLA-DRB5/ITGA4/HLA-DRB1/HLA-DRA/HLA-C/TIGIT/PTPRC/HLA-DPB1/HLA-DPA1/CD58/HLA-A/HLA-DQA2/HLA-DQA1/ITGB7/HLA-G/ITGAV	3.20561717381679
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/478	110/9376	2.31814378090529	PIK3R1/PFKFB3/PLCG2/IFNGR1/LDHA/IGF1/NFKB1/CREBBP/HIF1A/STAT3/PRKCA/EIF4E/RBX1	3.22304497213329
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/478	86/9376	2.50890337647173	PIK3R1/CBLB/PLCG2/BRAF/PAK1/PAK2/SOS2/PRKCA/MYC/MAPK8/ABL1	3.25803829561742
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/478	100/9376	2.35380753138075	CD44/HLA-DRB5/ITGA4/HLA-DRB1/HLA-DRA/IL9R/HLA-DPB1/HLA-DPA1/HLA-DQA2/IL4R/MME/HLA-DQA1	3.15449571359856
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/478	226/9376	1.82263857518421	PDE4D/PIK3R1/ATP1B3/PDE4B/PPP1CB/F2R/ADCY3/CALM1/BRAF/NFKB1/ROCK1/TIAM1/PAK1/PDE3B/CREBBP/CALM3/VIPR2/ADRB1/MAPK8/RHOA/ADORA2A	2.90139012740564
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	17/478	170/9376	1.96150627615063	PIK3R1/CTNNB1/NFE2L2/ACTB/SMAD3/PLCG2/TGFBR2/BAX/BRAF/TGFB1/CDK6/SOS2/BRD7/PRKCA/MYC/SMARCC1/SMAD4	2.93220604409055
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/478	78/9376	2.51475163609055	PIK3R1/ARPC3/CTNNB1/ACTB/CDC42/ARPC2/ARPC5/RHOA/ACTR2/ACTR3	3.11348907729939
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/478	91/9376	2.37105154259966	PDE4D/GNG2/PDE4B/PDE7A/GRK5/ADCY3/PDE3B/GNG4/PRKCA/PDE1C/PDE8A	3.04604917088315
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/478	105/9376	2.24172145845786	UBC/GABARAPL1/FOXO3/USP15/HIF1A/VCP/EIF2AK3/TBC1D15/ATG9A/MAP1LC3A/CCZ1/MAPK8	2.96557513120489
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/478	105/9376	2.24172145845786	PIK3R1/CBLB/PLCG2/CALM1/NFKB1/PAK1/RELB/CALM3/ITPR3/MAPK8/RHOA/IRF9	2.96557513120489
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	20/478	216/9376	1.81620951495428	PIK3R1/CYBA/NFE2L2/CDC42/CYCS/HSP90B1/BAX/CALM1/LYN/NFKB1/TAB2/MAP2K3/EIF2AK3/STAT3/MAP3K5/CALM3/PRKCA/MAPK8/RHOA/FAS	2.8127697176394
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	21/478	233/9376	1.76788119309713	ATP1B3/EMD/MYH9/COL3A1/ITGA4/ACTB/LBR/VIM/CAPZA1/SPTBN1/TPM3/LMNA/FMNL1/COL1A1/LMNB1/DIAPH1/COL6A1/COL6A3/TMOD3/ITGB7/ITGAV	2.75093936161582
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/478	149/9376	1.97467074780265	GNG2/NDUFB2/NDUFA13/ADCY3/NDUFA4/NDUFS6/MT-ND6/GNG4/PRKCA/ITPR3/NDUFB6/NDUFA6/NDUFC2/MAPK8/NDUFA11	2.7795480862573
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/478	60/9376	2.61534170153417	GNA13/LYN/IGF1/BRAF/PPP2CA/PRKCA/ITPR3/GNA12	2.90923414398193
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/478	98/9376	2.20169071812826	PIK3R1/PLCG2/SACM1L/IP6K1/CALM1/MTMR3/MTMR6/CALM3/PRKCA/ITPR3/CDS2	2.77160889364858
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/478	125/9376	2.03996652719665	PIK3R1/FYN/GNA13/GAB2/BAX/NFKB1/ROCK1/MAP3K5/PPP2CA/PRKCA/MAPK8/RHOA/GNA12	2.71289767250266
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/478	168/9376	1.86810121538155	PIK3R1/MCL1/IL12RB2/IFNGR1/IL21R/IL9R/CREBBP/SOS2/JAK1/STAT3/STAM/CCND2/IL4R/MYC/PDGFRA/IRF9	2.63145371530518
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/478	184/9376	1.81226123340004	CXCR4/PIK3R1/FYN/MYL12B/PLCG2/CDC42/CFL1/ROCK1/SSH1/EPHA4/PAK1/PAK2/RASA1/PRKCA/RHOA/PARD6G/ABL1	2.57900993838384
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/478	142/9376	1.93387942719076	PIK3R1/CTNNB1/CYBA/NFE2L2/ACTB/HSP90B1/CALM1/NFKB1/MAP3K5/CALM3/MAPK8/RHOA/TXN/ITGAV	2.59892311117737
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/478	51/9376	2.69226351628518	ACTB/PLCG2/ADCY3/KDELR2/SEC61B/SEC61G/PRKCA	2.80854925770409
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/478	90/9376	2.17945141794514	EML4/PIK3R1/IFNGR1/CD247/NFKB1/PRKCQ/MAP2K3/HIF1A/JAK1/STAT3	2.60579566760599
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/478	20/9376	3.92301255230126	LBR/SC5D/EBP/CYP51A1	3.03287113251428
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/478	78/9376	2.26327647248149	CNOT6L/BTG1/TENT4B/DDX6/LSM7/DHX36/PABPC4/XRN1/BTG3	2.59659564311922
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/478	105/9376	2.05491133691971	EMD/ITGA4/ACTB/TPM3/ADCY3/LMNA/IGF1/TGFB1/ADRB1/ITGB7/ITGAV	2.51942076468621
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/478	31/9376	3.16371980024295	SRP14/SPCS2/SEC61B/SEC61G/SPCS3	2.79669817616539
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/478	93/9376	2.1091465334953	CDC42/ADCY3/CALM1/MAP2K3/SOS2/PTK2B/CALM3/PRKCA/ITPR3/MAPK8	2.49137791937662
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/478	67/9376	2.34209704615	PPP1CB/RPS6KA3/CALM1/BRAF/CREBBP/CALM3/PRKCA/ITPR3	2.55518996100533
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/478	21/9376	3.7362024307631	CHST12/CHST7/XYLT1/CSGALNACT2	2.90930572535248
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/478	122/9376	1.92935043555799	PIK3R1/ATP1B3/CTNNB1/FOXO1/ACTB/PLCG2/CREBBP/HIF1A/PRKCA/MYC/ITGAV/MED14	2.39468316124738
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/478	68/9376	2.30765444253015	PIK3R1/ZBTB16/BRAF/NFKB1/SOS2/BCL2A1/STAT3/MYC	2.50826055473478
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/478	34/9376	2.88456805316269	CRY1/SKP1/CSNK1D/RORB/RBX1	2.55143634434574
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/478	142/9376	1.79574518239142	CBLB/UBC/UBE2B/ITCH/UBA6/FBXW7/BIRC2/RNF7/UBA2/CUL3/SKP1/UBE2M/RBX1	2.21450487601615
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/478	59/9376	2.32721083611091	PIK3R1/CTNNB1/FOXO3/BAX/BRAF/SOS2/MYC	2.37017963755415
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	27/478	362/9376	1.46300191867588	PIK3R1/GNG2/MCL1/YWHAZ/ITGA4/FOXO3/F2R/HSP90B1/IGF1/NFKB1/COL1A1/CDK6/SOS2/JAK1/COL6A1/GNG4/YWHAB/PPP2CA/PRKCA/CCND2/EIF4E/IL4R/MYC/PDGFRA/COL6A3/ITGB7/ITGAV	2.08224431450787
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	11/478	115/9376	1.87622339457886	JUND/PDE4D/PDE4B/AKAP13/GNA13/ADCY3/BRAF/PRKCA/ITPR3/RHOA/GNA12	2.19123122635058
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/478	87/9376	2.0291444236041	ATP1B3/MT-CO3/TPM3/COX6C/COX7A2/UQCRB/UQCRQ/UQCRFS1/COX6A1	2.23514064383408
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/478	130/9376	1.81062117798519	PIK3R1/GNG2/COL3A1/TGFBR2/ADCY3/NFKB1/COL1A1/TGFB1/SOS2/GNG4/PRKCA/MAPK8	2.15707906133881
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/478	75/9376	2.09227336122734	CYCS/BAX/IGF1/CDK6/CCND2/SESN1/FAS/EI24	2.20115455276591
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/478	103/9376	1.90437502538896	PIK3R1/IFNGR1/TGFBR2/CD247/CALR/NFKB1/TGFB1/PPP2CA/MAPK8/FAS	2.13899824831709
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/478	49/9376	2.40184441977628	GALNT11/B4GALT1/OGT/GALNT2/LFNG/GALNT3	2.28023839777131
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/478	37/9376	2.65068415696031	CTNNB1/TPM3/BAX/BRAF/MYC	2.33167514428352
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/478	76/9376	2.06474344857961	ATP1B3/EZR/ACTB/ADCY3/CALM1/CALM3/PRKCA/ITPR3	2.16004940332443
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/478	90/9376	1.96150627615063	PIK3R1/FOXO1/FOXO3/BAX/ADCY3/IGF1/NFKB1/EIF4E/SESN1	2.12428324782921
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/478	119/9376	1.81315706198798	PIK3R1/TNFRSF1B/TNFAIP3/NFKB1/TAB2/ITCH/MAP2K3/BIRC2/MAP3K5/MAPK8/FAS	2.06902706957676
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/478	106/9376	1.85047761901003	PIK3R1/CTNNB1/FOXO1/HSP90B1/IGF1/BRAF/NFKB1/CREBBP/SOS2/PDGFRA	2.04093578572311
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/478	122/9376	1.76857123259483	PIK3R1/PLCG2/ADCY3/IGF1/MAP2K3/CREBBP/SOS2/STAT3/PRKCA/ITPR3/MAPK8	1.98039890927573
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	9/478	93/9376	1.89823188014577	PIK3R1/CYCS/BAX/NFKB1/TRAF4/CDK6/BIRC2/MYC/ITGAV	2.01761895754489
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/478	138/9376	1.70565763143533	PPP1CB/YWHAZ/RPS6KA3/ADCY3/CALM1/IGF1/CALM3/YWHAB/PPP2CA/ITPR3/SKP1/RBX1	1.93552146792849
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	12/478	138/9376	1.70565763143533	PIK3R1/CBLB/PPP1CB/FOXO1/CALM1/BRAF/PDE3B/SOS2/PRKAR2A/CALM3/EIF4E/MAPK8	1.93552146792849
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/478	169/9376	1.62491644178159	PIK3R1/UBC/GABARAPL1/MTMR3/PRKCQ/HIF1A/RAB1A/EIF2AK3/ATG2A/PPP2CA/ATG9A/MAP1LC3A/RUBCN/MAPK8	1.90002632334158
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	10/478	109/9376	1.79954704234003	PIK3R1/PPP1CB/FOXO1/RPS6KA3/OGT/NFKB1/PRKCQ/STAT3/MAPK8/OGA	1.94599210665116
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/478	201/9376	1.56139803076667	ZBTB16/FOXO1/TGFBR2/BAX/IGF1/NFKB1/DDX5/REL/BCL2A1/BIRC2/KDM6A/CCND2/MYC/JMJD1C/ITGB7/CCNT2	1.86474419115943
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/478	95/9376	1.85826910372165	ITGB2/HLA-DRB5/HLA-DRB1/HLA-DRA/TGFB1/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DQA1	1.94868337946973
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/478	69/9376	1.98993390334122	PTGER4/CALM1/PDE3B/CALM3/ITPR3/ADRB1/PDE1C	1.91284276426227
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/478	144/9376	1.63458856345886	PIK3R1/CTNNB1/SMAD3/IGF1/KAT6A/ACVR1B/JAK1/STAT3/RIF1/PCGF5/MYC/SMAD4	1.77860281332772
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	9/478	99/9376	1.7831875237733	EMD/ITGA4/ACTB/TPM3/LMNA/IGF1/TGFB1/ITGB7/ITGAV	1.81565347550984
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/478	71/9376	1.93387942719076	PIK3R1/FOXO3/NFKB1/SOS2/STAT3/CCND2/MAPK8	1.83069156151704
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/478	71/9376	1.93387942719076	PLCG2/CDC42/LYN/NFKB1/PAK1/GIT1/MAPK8	1.83069156151704
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/478	243/9376	1.45296761196343	SRSF2/HNRNPA3/TRA2A/SRSF7/SRSF10/SRSF5/HNRNPM/LSM7/DDX5/RBM8A/SNRPB/WBP11/BCAS2/ALYREF/SNRPA1/SF3B2/SNRPG/SNU13	1.65812376564581
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/478	44/9376	2.22898440471662	B4GALT1/STT3B/MAN1A1/ALG13/RPN2	1.89382014047667
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/478	32/9376	2.45188284518828	GABARAPL1/ATG2A/PPP2CA/ATG9A	1.90674902908512
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/478	32/9376	2.45188284518828	CYCS/BAX/BIRC2/MAPK8	1.90674902908512
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/478	103/9376	1.71393752285006	PPP1CB/GSPT1/RBM8A/PABPC4/PPP2CA/CPSF6/SRRM1/PABPN1/ALYREF	1.68858169223253
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/478	89/9376	1.76315170889944	TUBA4A/ADCY3/SOS2/PRKCA/ITPR3/ADRB1/PDGFRA/CSNK1D	1.67656944656663
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/478	105/9376	1.6812910938434	TNFAIP3/PLCG2/LYN/NFKB1/TAB2/PRKCQ/RELB/BCL2A1/BIRC2	1.62711203164886
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	14/478	187/9376	1.46850737251919	TNFAIP3/CYBA/GABARAPL1/NAMPT/NFKB1/TAB2/JAK1/BIRC2/MAP1LC3A/ITPR3/MAPK8/RHOA/IRF9/TXN	1.49987992614159
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	6/478	63/9376	1.86810121538155	RPA1/CCNH/POLR2K/POLE4/RAD23B/RBX1	1.60231988842829
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/478	140/9376	1.54118350268978	GNG2/GNA13/SMAD3/ADCY3/CALM1/PDE3B/CALM3/GNG4/MAP1LC3A/ITPR3/SMAD4	1.49527127624605
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/478	78/9376	1.76032614526338	ITGB2/CFL1/CALM1/NFKB1/CALM3/MAPK8/RHOA	1.56280877475889
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/478	157/9376	1.49924046584761	DUSP4/ATP11B/DUSP16/PTGER4/CALR/ATP8A1/TGFB1/DNMT3A/HIF1A/DUSP8/UQCRFS1/ITGAV	1.46207982461674
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/478	36/9376	2.17945141794514	GALNT11/B4GALT5/GALNT2/GALNT3	1.64327880933138
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	10/478	128/9376	1.53242677824268	PDE4D/PDE4B/PDE7A/GUK1/ADCY3/PDE9A/PDE3B/APRT/PDE1C/PDE8A	1.40570551967365
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/478	178/9376	1.4325607634808	TBL1X/CTNNB1/SMAD3/CREBBP/PRKCA/CCND2/APCDD1/MYC/MAPK8/RHOA/SKP1/SMAD4/RBX1	1.35040428528149
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/478	38/9376	2.06474344857961	PIK3R1/ATP1B3/IGF1/PRKCA	1.52427464589421
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/478	83/9376	1.65428240157282	OGT/KDM2B/FOXK2/CREBBP/PCGF5/SKP1/ASXL1	1.38764924117493
NA	NA	hsa04519	Cadherin signaling	26/478	404/9376	1.26235552425535	KRT86/ARPC3/KRT81/PPP1CB/CTNNB1/YWHAZ/ACTB/CDC42/VIM/NFKB1/ROCK1/ARPC2/MAP2K3/CREBBP/BRK1/PTK2B/YWHAB/ACTN1/ARPC5/PDGFRA/MAPK8/RHOA/ACTR2/ACTR3/NCKAP1L/LHFPL3	1.24936590285111
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/478	99/9376	1.58505557668738	ITGB2/HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DQA1	1.35632675308849
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/478	99/9376	1.58505557668738	PIK3R1/GPCPD1/CHPT1/SOS2/HIF1A/PRKCA/PDGFRA/MAPK8	1.35632675308849
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/478	166/9376	1.41795634420527	ATP1B3/GNA13/PPP1CB/ADCY3/CALM1/ROCK1/PDE3B/CALM3/ITPR3/ADRB1/RHOA/GNA12	1.25924007498336
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/478	150/9376	1.43843793584379	PIK3R1/CTNNB1/SMAD3/TGFBR2/BAX/BRAF/ABCB1/TGFB1/SOS2/MYC/SMAD4	1.25458593562282
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/478	86/9376	1.59657487593656	EMD/CTNNB1/ITGA4/ACTB/LMNA/ITGB7/ITGAV	1.28813005677632
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/478	168/9376	1.40107591153616	TNFAIP3/IFNGR1/BAX/JAK1/STAT3/BIRC2/EIF2AK2/CHMP4A/CHMP4B/MAPK8/IRF9/FAS	1.21577147783092
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	21/478	323/9376	1.27528271824035	CD44/ZEB2/PIK3R1/MCL1/EZR/PLCG2/VIM/NFKB1/ROCK1/ABCB1/CDK6/CREBBP/SOS2/DNMT3A/STAT3/PRKCA/CCND2/MYC/PDGFRA/RHOA/ABL1	1.16690992795791
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/478	71/9376	1.65761093759208	PIK3R1/SLC7A5/LDHA/HIF1A/MYC/PDGFRA	1.28912015744107
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/478	103/9376	1.52350002031117	PIK3R1/ITGB2/COL3A1/NFKB1/COL1A1/TGFB1/ACTN1/PRKCA	1.23816513614797
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/478	56/9376	1.7513448894202	B4GALT1/STT3B/MAN1A1/ALG13/RPN2	1.30700960710108
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/478	56/9376	1.7513448894202	ITGB2/CYCS/NFKB1/RAB1A/VCP	1.30700960710108
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/478	14/9376	2.80215182307232	B4GALT1/B3GNT7	1.56395574867084
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/478	73/9376	1.61219693930189	PIK3R1/BAX/IGF1/BRAF/CDK6/PDGFRA	1.21701087598373
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/478	89/9376	1.54275774528701	CD44/ITGA4/COL1A1/COL6A1/COL6A3/ITGB7/ITGAV	1.19238552705056
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/478	107/9376	1.46654674852383	FOXO1/CALM1/LDHA/PDE3B/CREBBP/CALM3/ITPR3/PRMT1	1.12492611928976
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/478	59/9376	1.66229345436494	PIK3R1/PLAAT2/ADCY3/PDE3B/ADRB1	1.18274686802662
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/478	29/9376	2.0291444236041	CALM1/CALM3/SLC24A1	1.2864490440363
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/478	75/9376	1.5692050209205	PIK3R1/CYCS/BAX/BIRC2/MAP3K5/FAS	1.14706470717966
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/478	75/9376	1.5692050209205	ATP1B3/TG/HSP90B1/ADCY3/PRKCA/ITPR3	1.14706470717966
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/478	158/9376	1.36560563529474	PIK3R1/RPS6KA3/PRR5L/SLC7A5/IGF1/BRAF/CAB39/SOS2/PRKCA/EIF4E/RHOA	1.07417850726802
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/478	44/9376	1.7831875237733	ARHGDIB/DCTN6/ADCY3/DCTN5	1.20686340737898
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/478	108/9376	1.45296761196343	NUP98/KPNA2/KPNA6/KPNA1/RBM8A/SRRM1/NUP58/ALYREF	1.09733542901892
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/478	60/9376	1.63458856345886	PIK3R1/PLCG2/CDC42/SH2D2A/PRKCA	1.14289547186305
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/478	93/9376	1.47640257344671	ATP1B3/ADCY3/CALM1/CALM3/PRKCA/ITPR3/ADRB1	1.07010103388144
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/478	144/9376	1.36215713621571	CTNNB1/FOXO1/TRA2A/FOXO3/NFKB1/TAB2/MAP2K3/MAP3K5/MAPK8/FAS	1.01504145903465
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/478	94/9376	1.46069616309089	JUND/TNFAIP3/HSP90B1/NFKB1/TAB2/TRAF4/MAPK8	1.04042583045226
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/478	62/9376	1.58185990012147	PIK3R1/FOXO1/FOXO3/ADCY3/IGF1	1.065367739711
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/478	217/9376	1.26548792009718	PIK3R1/RPS6KA3/HSP90B1/ADCY3/NFKB1/KPNA2/KPNA6/SOS2/KPNA1/AHR/STAT3/PRKCA/ADRB1/MYC	0.917073171035843
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/478	97/9376	1.41551999309839	GNG2/ADCY3/CALM1/CALM3/GNG4/PRKCA/ITPR3	0.95341194912411
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/478	98/9376	1.40107591153616	ATP1B3/ADCY3/CALM1/CALM3/PRKD3/PRKCA/ITPR3	0.925051302029943
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/478	133/9376	1.32733507408689	GNG2/PPP1CB/CALM1/CALM3/GNG4/PPP2CA/PRKCA/ITPR3/MAPK8	0.881181300419712
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/478	99/9376	1.38692362960145	PIK3R1/BAX/ADCY3/IGF1/BRAF/SOS2/MAPK8	0.897000030667131
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/478	154/9376	1.27370537412378	CREM/ATP1B3/PPP1CB/TPM3/ADCY3/CALM1/CALM3/PPP2CA/PRKCA/ADRB1	0.793751414099604
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/478	154/9376	1.27370537412378	MYL6/PPP1CB/ACTB/ADCY3/CALM1/ROCK1/CALM3/PRKCA/ITPR3/RHOA	0.793751414099604
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/478	103/9376	1.33306251777227	ATP1B3/COL3A1/COL1A1/COL6A1/COL23A1/MME/COL6A3	0.787748580063416
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/478	36/9376	1.63458856345886	RPA1/MCM6/POLE4	0.884144885588228
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/478	122/9376	1.28623362370533	PIK3R1/PFKFB3/FOXO1/FOXO3/IGF1/CAB39/PPP2CA/RAB2A	0.737546153360788
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/478	70/9376	1.40107591153616	TNFRSF1B/NFKB1/PRKCQ/STAT3/MAPK8	0.780633996670329
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/478	194/9376	1.21330285122719	MYL6/MYH9/MYO5B/BICDL1/TUBA4A/MYL12B/ACTB/DCTN6/CAPZA1/TPM3/DCTN5/DYNLT1	0.695796543966737
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/478	89/9376	1.32236378167458	GNG2/GABARAPL1/ADCY3/PLCL1/GNG4/PRKCA	0.70820160753449
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/478	143/9376	1.23451443953536	HLA-DRB5/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/SNRPB/ACTN1/HLA-DQA2/HLA-DQA1	0.654967235377753
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/478	254/9376	1.15836984812045	CXCR4/PLCG2/F2R/ADCY3/CALM1/PTK2B/CALM3/PRKCA/P2RX5/ITPR3/ADRB1/PDGFRA/PDE1C/MCOLN2/ADORA2A	0.593058739762896
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/478	91/9376	1.293300841418	PIK3R1/IFITM1/PLCG2/LYN/NFKB1/SOS2	0.651623047756921
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/478	109/9376	1.25968292963802	PIK3R1/NFKB1/TAB2/MAP2K3/JAK1/MAPK8/IRF9	0.632034019947915
NA	NA	hsa04081	Hormone signaling	13/478	219/9376	1.16436445616247	PIK3R1/GNG2/GNA13/ADCY3/IGF1/STAT3/VIPR2/GNG4/ADRB1/RHOA/SMAD4/GNA12/ITGAV	0.570435760119679
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/478	110/9376	1.24823126664131	PIK3R1/RPS6KA3/ADCY3/IGF1/BRAF/PDE3B/MAPK8	0.606959989846535
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/478	24/9376	1.63458856345886	EXT1/XYLT1	0.721437974373013
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/478	298/9376	1.1189800904215	CXCR4/TNFRSF1B/CCR9/BMP8A/IL12RB2/IFNGR1/TGFBR2/ACVR1B/IL21R/IL9R/RELL1/TGFB1/CXCR6/RELT/CCR5/IL4R/FAS	0.483771994249011
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/478	78/9376	1.25737581804527	PLCG2/SACM1L/IP6K1/MTMR3/MTMR6	0.529021906398558
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/478	115/9376	1.19396034200473	PIK3R1/GNG2/FYN/ADCY3/GNG4/PRKCA/ITPR3	0.485049772357055
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/478	62/9376	1.26548792009718	ATXN1/ITCH/CREBBP/LFNG	0.486100288566814
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/478	101/9376	1.16525125315879	CTNNB1/ADCY3/CALM1/CREBBP/CALM3/PRKCA	0.386991900077957
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/478	28/9376	1.40107591153616	B3GNT5/B4GALT1	0.492605922329359
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	5/478	85/9376	1.15382722126508	GUK1/CTPS1/TYMS/APRT/NT5C3A	0.330190682267637
NA	NA	hsa03272	Virion - Hepatitis viruses	3/478	48/9376	1.22594142259414	CD63/CHMP4A/CHMP4B	0.363727045287547
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/478	30/9376	1.30767085076708	NFKB1/TYMS	0.391189759388141
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/478	12/9376	1.63458856345886	NPC1	0.509806710012433
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/478	69/9376	1.13710508762355	PPP1CB/CALM1/CALM3/PRKCA	0.264927258192772
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/478	50/9376	1.17690376569038	ITGB2/TGFB1/GYPC	0.29068843923618
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/478	148/9376	1.06027366278412	PIK3R1/CTNNB1/BAX/IGF1/BRAF/CDK6/SOS2/MYC	0.171300264908708
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/478	13/9376	1.50885098165433	XRCC6	0.4255084283996
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/478	72/9376	1.08972570897257	ISG15/RNF125/NFKB1/MAPK8	0.177133898806277
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	13/478	250/9376	1.01998326359833	LAPTM4A/LITAF/HGSNAT/CD63/AP1S1/CTSW/BORCS5/GGA2/OSBPL7/CLN8/SCARB2/MCOLN2/NPC1	0.0742248921259608
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/478	34/9376	1.15382722126508	POLR3E/POLR2K	0.20826011691473
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/478	54/9376	1.08972570897257	RPA1/WDR48/FANCA	0.153254281037368
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/478	35/9376	1.12086072922893	PFKFB3/ENOSF1	0.166025934050184
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/478	15/9376	1.30767085076708	ST3GAL5	0.276391221442037
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/478	56/9376	1.05080693365212	CCND2/CUL3/CSNK1D	0.0883817156750931
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/478	238/9376	0.98899476108435	PIK3R1/ISG15/PLCG2/NFKB1/TAB2/MX1/JAK1/STAT3/EIF2AK2/PRKCA/MAPK8/IRF9	-0.0398580238480154
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/478	139/9376	0.987808916047079	PIK3R1/HSP90B1/ADCY3/CALM1/SOS2/CALM3/ITPR3	-0.0335612119969369
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/478	37/9376	1.06027366278412	PRKCA/FAS	0.0851396075839638
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/478	59/9376	0.997376072618963	CTPS1/TYMS/NT5C3A	-0.0046859015009086
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/478	17/9376	1.15382722126508	MYH9	0.147128334196578
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/478	102/9376	0.961522684387563	ATP1B3/ADCY3/PRKCA/ITPR3/RHOA	-0.0905575556796853
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/478	18/9376	1.08972570897257	LMBRD1	0.0883110435085304
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/478	104/9376	0.943031863533956	GPCPD1/PLAAT2/CHPT1/AGPAT4/CDS2	-0.135398968896054
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/478	41/9376	0.956832329829574	BRAF/MYC	-0.0642017347101943
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/478	63/9376	0.934050607690775	PHYKPL/SETD2/KMT2C	-0.121727767516586
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/478	19/9376	1.0323717242898	HGSNAT	0.0327361577165685
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/478	42/9376	0.934050607690775	MAP1LC3A/PCBP2	-0.0992784369158934
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/478	86/9376	0.912328500535176	ATP1B3/ADCY3/PRKCA/ITPR3	-0.189301122354504
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/478	65/9376	0.905310588992597	ADCY3/ITPR3/PDE8A	-0.177546990793213
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/478	65/9376	0.905310588992597	PIK3R1/PRKCA/ITPR3	-0.177546990793213
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/478	155/9376	0.885841544068025	CTNNB1/ADCY3/BRAF/CDK6/AHR/ITPR3/PDE8A	-0.332153099859049
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/478	47/9376	0.834683521766225	PIK3R1/MAPK8	-0.263330348007907
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/478	23/9376	0.852828815717664	B4GALT1	-0.163781415895237
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/478	23/9376	0.852828815717664	IDI1	-0.163781415895237
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/478	23/9376	0.852828815717664	RPA1	-0.163781415895237
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/478	23/9376	0.852828815717664	MME	-0.163781415895237
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/478	23/9376	0.852828815717664	ATP1B3	-0.163781415895237
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/478	115/9376	0.852828815717664	GNG2/BRAF/GNG4/PRKCA/ITPR3	-0.368040954639709
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/478	48/9376	0.817294281729428	PIK3R1/ATP1B3	-0.294124956374498
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/478	116/9376	0.845476843168374	GNG2/ADCY3/GNG4/PRKCA/ITPR3	-0.388123964693184
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	5/478	117/9376	0.838250545363516	ACTB/BAZ1A/BRD7/SMARCA5/SMARCC1	-0.408044097180115
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/478	51/9376	0.76921814751005	PLAAT2/CHPT1	-0.383014934887361
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/478	26/9376	0.754425490827164	PLAAT2	-0.290614673807363
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/478	26/9376	0.754425490827164	LMBRD1	-0.290614673807363
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/478	52/9376	0.754425490827164	ADCY3/IGF1	-0.411563839280418
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/478	52/9376	0.754425490827164	TSPO/NPC1	-0.411563839280418
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/478	76/9376	0.774278793217353	UBC/DBI/FABP5	-0.457921538450371
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/478	27/9376	0.726483805981714	OXCT2	-0.329864616433637
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/478	100/9376	0.784602510460251	CXCR4/TNFRSF1B/CCR9/CCR5	-0.501895905971239
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/478	53/9376	0.74019104760401	ATP1B3/PRKCA	-0.439610027619897
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/478	191/9376	0.821573309382462	GNG2/PPP1CB/CALM1/BRAF/SOS2/CALM3/GNG4/ADORA2A	-0.577417988595216
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/478	54/9376	0.726483805981714	LDHA/DNMT3A	-0.467174103680404
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/478	29/9376	0.676381474534699	PAK1	-0.40452897879902
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/478	30/9376	0.653835425383542	PGAP1	-0.440132811786658
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/478	30/9376	0.653835425383542	PLAAT2	-0.440132811786658
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/478	83/9376	0.708978172102636	NFKB1/POLR3E/POLR2K	-0.617220053109091
NA	NA	hsa04981	Folate transport and metabolism	1/478	31/9376	0.63274396004859	TYMS	-0.474693764415571
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/478	32/9376	0.612970711297071	B4GALT1	-0.508283242623556
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/478	32/9376	0.612970711297071	LDHA	-0.508283242623556
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/478	63/9376	0.622700405127183	CTNNB1/BAX	-0.696410319498212
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/478	90/9376	0.653835425383542	ATP1B3/ADCY3/ABCB1	-0.764791270831461
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/478	67/9376	0.585524261537501	LDHA/BPGM	-0.789111524414516
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/478	38/9376	0.516185862144902	NAMPT	-0.692622832891329
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/478	38/9376	0.516185862144902	PTPRC	-0.692622832891329
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/478	39/9376	0.50295032721811	TYMS	-0.720911248818157
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/478	195/9376	0.704130458105353	PIK3R1/ITGB2/CYBA/ACTB/PLCG2/NFKB1/PRKCA	-0.967667058730602
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/478	41/9376	0.478416164914787	BPGM	-0.775733016793859
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/478	41/9376	0.478416164914787	RPA1	-0.775733016793859
NA	NA	hsa04082	Neuroactive ligand signaling	7/478	199/9376	0.689977082063035	GNG2/ADCY3/GNG4/PRKCA/P2RX5/ADRB1/ADORA2A	-1.02452688101085
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/478	44/9376	0.445796880943324	CCNH	-0.854006791914117
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/478	44/9376	0.445796880943324	POLE4	-0.854006791914117
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/478	45/9376	0.435890283589028	ABCB1	-0.879142201870562
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/478	47/9376	0.417341760883112	LDHA	-0.928108307868471
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/478	48/9376	0.408647140864714	OXCT2	-0.951976958036544
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/478	49/9376	0.400307403296046	NFKB1	-0.975459235399154
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/478	86/9376	0.456164250267588	ITPR3/PDE1C	-1.17425524177505
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/478	88/9376	0.445796880943324	ITGB2/F2R	-1.21060533696868
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/478	55/9376	0.35663750475466	B4GALT5	-1.10907066087485
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/478	59/9376	0.332458690872988	PRDX6	-1.19211867102844
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/478	61/9376	0.321558405926332	ATP1B3	-1.23208122483326
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/478	63/9376	0.311350202563592	PLAAT2	-1.27109287147984
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/478	65/9376	0.301770196330866	AGPAT4	-1.30921292259278
NA	NA	hsa04382	Cornified envelope formation	6/478	217/9376	0.542351965755934	KRT86/S100A4/KRT81/S100A6/PPP2CA/S100A10	-1.58085058570236
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/478	370/9376	0.636164197670474	NR3C1/PGRMC2/GPR35/PTGER4/F2R/P2RY8/TSPO/P2RY10/VIPR2/P2RX5/ADRB1/ADORA2A	-1.6549836551714
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/478	183/9376	0.214372270617555	XRN1/SNU13	-2.48752299687184
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/478	154/9376	0.127370537412378	CTPS1	-2.53064402601261
Genetic Information Processing	Translation	hsa03010	Ribosome	2/478	222/9376	0.176712277130687	MRPL47/MRPL23	-2.87723979313914
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/478	449/9376	0.174744434400947	ADCY3/CALM1/CALM3/PDE1C	-4.15348121721732