category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/456	109/9376	4.33864477708032	HLA-DRB5/HLA-DRA/HLA-DQA1/STAT1/NFKB1/NFATC2/IL21R/RUNX1/JAK1/HLA-DQA2/IRF4/RORA/HLA-DRB1/HIF1A/IL2RB/STAT5B/MAPK8/MAPK1/TGFB1/IL27RA/TGFBR2/PRKCQ/STAT5A	7.92682943767095
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/456	173/9376	3.44670925869587	HLA-DRB5/PIK3R1/HLA-DRA/MX1/HLA-DQA1/EIF2AK2/STAT1/NFKB1/NUP98/JAK1/MX2/KPNA2/HLA-DQA2/HLA-DRB1/BAX/IFIH1/RSAD2/PABPN1/CDK6/CREBBP/OAS1/RAB11A/IRF9/ADAR/MAPK1/KPNA6/TRAF3/OAS2/PRKCB	7.34389296120057
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	20/456	93/9376	4.42180720618751	HLA-DRB5/HLA-DRA/STAT4/HLA-DQA1/STAT1/NFKB1/NFATC2/JAK1/HLA-DQA2/IL12RB2/HLA-DRB1/RUNX3/IL2RB/RBPJ/STAT5B/MAPK8/MAPK1/MAML1/PRKCQ/STAT5A	7.49787969797378
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	28/456	203/9376	2.83605565638234	FYN/PIK3R1/COL1A1/IGF1/PPP1CB/BRAF/COL6A1/ITGA4/PDGFRA/ITGA1/COL6A3/CTNNB1/PDGFD/LAMA2/MAPK8/MAPK1/ACTN4/SOS1/FN1/DIAPH1/RAP1B/BIRC3/LAMB1/PARVB/PIP5K1A/COL4A2/PRKCB/FLNA	5.97948521511487
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/456	205/9376	2.80838682071031	HLA-DRB5/PIK3R1/CD44/ISG15/HLA-DRA/HLA-DQA1/TNFAIP3/EIF2AK2/STAT1/NFKB1/JAK1/HLA-DQA2/PLCG2/HLA-DRB1/RUNX3/RELB/BAX/CDK6/RBPJ/OAS1/IRF9/MAPK8/LYN/BCL2L11/TRAF3/MAP3K14/OAS2/HLA-G	5.91896196796996
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/456	101/9376	3.66440854611777	COL3A1/PIK3R1/COL1A1/STAT1/NFKB1/PLCG2/BAX/FOXO1/STAT5B/MAPK8/MAPK1/TGFB1/FN1/DIAPH1/TGFBR2/STAT5A/COL4A2/PRKCB	6.08681606357797
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/456	156/9376	3.0314889788574	PIK3R1/MX1/EIF2AK2/STAT1/NFKB1/JAK1/BRAF/MX2/BAX/RSAD2/CDK6/OAS1/PPP2R2D/YWHAZ/CTNNB1/PIAS1/PPP2CA/IRF9/IFIT1/MAPK1/SOS1/TRAF3/OAS2	5.78491446014353
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/456	333/9376	2.28460038986355	PIK3R1/COL1A1/ISG15/MX1/EIF2AK2/STAT1/NFKB1/JAK1/MX2/COL6A1/ITGA4/UBR4/BAX/FOXO1/ITGA1/CDK6/RBPJ/CREBBP/PPP2R2D/COL6A3/CTNNB1/LAMA2/OASL/PPP2CA/IRF9/MAPK1/SOS1/FN1/PARD6G/TRAF3/LAMB1/PPP2R5A/MAML1/COL4A2/PTGER4/HLA-G/RPS6KB1	5.39659135303781
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/456	136/9376	3.17492260061919	CBLB/PIK3R1/MX1/TNFAIP3/EIF2AK2/STAT1/NFKB1/JAK1/MX2/BAX/IFIH1/IL2RB/CDK6/OAS1/STAT5B/IRF9/ADAR/MAPK8/TRAF3/OAS2/STAT5A	5.77647512057531
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	26/456	196/9376	2.72753311851056	PIK3R1/EIF2AK2/GNG2/STAT1/NFKB1/NFATC2/JAK1/PLCG2/CLEC2B/BAX/ZFP36/HIF1A/CDK6/CREBBP/PIK3R6/UBC/CTNNB1/GNB1/IRF9/MAPK8/LYN/MAPK1/TRAF3/ITPR1/HLA-G/GNG4	5.52609961547029
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/456	224/9376	2.57017543859649	HLA-DRB5/PIK3R1/HLA-DRA/HLA-DQA1/NFKB1/NFATC2/KAT2B/JAK1/HLA-DQA2/HLA-DRB1/ITGB2/RELB/BAX/EGR2/ZFP36/IL2RB/CREBBP/STAT5B/ETS1/MAPK8/BUB1B/MAPK1/TGFB1/TGFBR2/MAP3K14/STAT5A/HLA-G/ADCY3	5.37774017415896
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/456	66/9376	4.04997341839447	HLA-DRB5/HLA-DRA/STAT4/HLA-DQA1/STAT1/NFKB1/IL21R/HLA-DQA2/IL12RB2/RORA/HLA-DRB1/TGFB1/NOD2	5.62184430695804
NA	NA	hsa04518	Integrin signaling	21/456	154/9376	2.80382775119617	PIK3R1/COL1A1/IGF1/COL6A1/ITGB2/ITGA4/PDGFRA/ITGA1/COL6A3/CTNNB1/PDGFD/LAMA2/ACTN4/TGFB1/FN1/LAMB1/PARVB/COL4A2/ITGAM/FBN1/FLNA	5.10303442298601
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/456	98/9376	3.35696383816685	PIK3R1/SACM1L/PLCG2/IP6K1/SYNJ1/PI4K2B/DGKB/PIK3C2B/INPP5D/PIP5K1A/ITPR1/CDS2/IPPK/PI4K2A/PIKFYVE/PRKCB	5.30303392571491
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/456	205/9376	2.50748823277706	PIK3R1/REL/EIF2AK2/NFKB1/KAT2B/JAK1/RASA2/UBR4/BAX/EGR2/CDK6/RBPJ/CREBBP/HDAC9/YWHAZ/SP100/STAT5B/IRF9/LYN/MAPK1/ACTN4/TRAF3/STAT5A/HLA-G/CDK1	4.93410226992527
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/456	180/9376	2.62729044834308	HLA-DRB5/PIK3R1/HLA-DRA/HLA-DQA1/EIF2AK2/PPP1CB/CD74/STAT1/NFKB1/JAK1/HLA-DQA2/HLA-DRB1/BAX/IFIH1/OAS1/SP100/IRF9/BIRC3/TRAF3/PILRB/OAS2/HLA-G/SRSF7	4.98410839540449
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/456	78/9376	3.69050832208727	HLA-DRB5/HLA-DRA/HLA-DQA1/STAT1/NFKB1/JAK1/HLA-DQA2/HLA-DRB1/ITGB2/ITGA4/MAPK1/TGFB1/ITGAM/PRKCB	5.39476464275202
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/456	163/9376	2.64901517597675	PIK3R1/STAT4/STAT1/NFKB1/NFATC2/JAK1/BRAF/BAX/EGR2/IFIH1/CREBBP/YWHAZ/STAT5B/MAPK8/MAPK1/TGFB1/SOS1/TGFBR2/TRAF3/STAT5A/PRKCB	4.80179429687628
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/456	142/9376	2.75117370892019	FYN/PIK3R1/FOSL2/JUND/STAT1/NFKB1/NFATC2/JAK1/PLCG2/CAMK4/RELB/TYROBP/IRF9/MAPK8/MAPK1/TGFB1/TGFBR2/MAP3K14/ITPR1	4.75405386147559
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	23/456	193/9376	2.45032269793655	PIK3R1/GNG2/CCL4/STAT1/NFKB1/CXCR4/BRAF/XCL2/PLCG2/CCL3/XCL1/ITK/PIK3R6/STAT5B/GNB1/ELMO1/LYN/MAPK1/SOS1/RAP1B/GNG4/ADCY3/PRKCB	4.60295404007057
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/456	133/9376	2.78274633953304	FYN/PIK3R1/FCER1G/NFATC2/BRAF/PLCG2/ITGB2/SH2D1B/KLRC1/KLRK1/TYROBP/NCR3/MAPK1/SH2D1A/SOS1/KIR2DL4/HLA-G/PRKCB	4.68160242824606
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/456	77/9376	3.47140578719526	PIK3R1/NFKB1/RUNX1/BRAF/BAX/CDK6/STAT5B/MAPK1/TGFB1/SOS1/ABL1/TGFBR2/STAT5A	4.92330714399728
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	17/456	122/9376	2.86511360368133	FYN/CBLB/PIK3R1/PTPRC/NFKB1/NFATC2/MAP3K8/ITK/PPP2R2D/PPP2CA/MAPK8/RASGRP1/MAPK1/SOS1/PPP2R5A/MAP3K14/PRKCQ	4.68819956064329
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/456	68/9376	3.62848297213622	PIK3R1/NFKB1/RUNX1/BRAF/ZBTB16/STAT5B/MAPK1/SOS1/RUNX1T1/STAT5A/ITGAM/RPS6KB1	4.91832325630983
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/456	227/9376	2.26447175206739	PIK3R1/GNA13/GNG2/CCL4/NFKB1/NFATC2/CXCR4/AKAP13/JAK1/CCL3/BAX/PDGFRA/CDK6/CTNNB1/GNB1/MAPK1/SOS1/GNA12/ITPR1/PTGER4/HLA-G/GNG4/ADCY3/RPS6KB1/PRKCB	4.36034526069068
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/456	80/9376	3.34122807017544	PIK3R1/IGF1/JAK1/BRAF/PLCG2/BAX/PDGFRA/PDGFD/MAPK1/SOS1/BCL2L11/RPS6KB1/PRKCB	4.7547347126328
NA	NA	hsa04517	IgSF CAM signaling	30/456	299/9376	2.06301707445872	FYN/PIK3R1/PLCG2/ITGB2/ITGA4/CASK/FOXO1/SH2D1B/CRTAM/MYH9/NLGN1/CTNNB1/SPTBN1/TUBA4A/MAPK8/SLIT3/LYN/MAPK1/ACTN4/SH2D1A/LRFN4/ABL1/RAP1B/RAPGEF2/PARD6G/RASA1/INPP5D/PRKCQ/ITGAM/PRKCB	4.22367311377612
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/456	115/9376	2.86071700991609	JUND/GNA13/PDE4B/AKAP13/NR4A2/BRAF/PDE4D/MEF2D/STK39/MAPK1/GNA12/ITPR1/WNK1/ADCY3/PRKCB/OXSR1	4.5392691895509
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	30/456	300/9376	2.05614035087719	IGF1/JUND/NFKB1/DUSP2/RASA2/BRAF/RPS6KA3/PPM1B/STK4/MAP3K8/RELB/PDGFRA/DUSP4/DUSP5/PDGFD/MAPK8/RASGRP1/MAP4K4/MAPK1/TGFB1/SOS1/TGFBR2/RAP1B/RAPGEF2/RASA1/MAP3K14/GNA12/CACNA2D1/PRKCB/FLNA	4.20359291794306
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/456	232/9376	2.2156684815487	PIK3R1/GNA13/PPP1CB/CXCR4/BRAF/ITGB2/IQGAP2/ITGA4/PDGFRA/ITGA1/MYH9/SSH1/RGCC/PDGFD/NCKAP1L/MAPK1/ACTN4/SOS1/FN1/DIAPH1/GNA12/PIP5K1A/ITGAM/SSH2/PIKFYVE	4.2391293939867
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/456	105/9376	2.93734335839599	CBLB/PIK3R1/FCER1G/STAT1/NFKB1/NFATC2/PLCG2/RELB/EGR2/IRF9/MAPK8/MAPK1/BCL3/MAP3K14/ITPR1	4.51360541224614
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/456	73/9376	3.37995674116799	EML4/PIK3R1/BRAF/PLCG2/STK4/BAX/CDK6/STAT5B/MAPK1/SOS1/STAT5A/PRKCB	4.61534972716502
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/456	99/9376	2.9076732234627	PIK3R1/GPCPD1/PDGFRA/HIF1A/PLPP3/PDGFD/MAPK8/MAPK1/SOS1/DGKB/CHKA/PIP5K1A/RPS6KB1/PRKCB	4.31423139834836
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/456	77/9376	3.20437457279563	PIK3R1/STAT1/NFKB1/JAK1/BRAF/BAX/CDK6/MAPK8/MAPK1/TGFB1/TGFBR2/RPS6KB1	4.39135213590612
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/456	112/9376	2.75375939849624	HLA-DRB5/HLA-DRA/HLA-DQA1/STAT1/NFKB1/JAK1/HLA-DQA2/HLA-DRB1/PIK3R6/LAMA2/MAPK8/MAPK1/TGFB1/BIRC3/LAMB1	4.22148627807417
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	16/456	125/9376	2.63185964912281	FYN/PIK3R1/GNA13/FCER1G/NFKB1/BAX/CERS6/SGMS1/PPP2R2D/PPP2CA/MAPK8/MAPK1/PPP2R5A/S1PR5/GNA12/PRKCB	4.15268608052371
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/456	204/9376	2.21740626074991	PIK3R1/COL1A1/IGF1/CD44/PPP1CB/BRAF/PLCG2/HPSE2/DCN/HIF1A/CTNNB1/TIMP3/TWIST2/MAPK1/TGFB1/SOS1/FN1/PDCD4/ITPR1/RPS6KB1/PRKCB/FLNA	3.97469880182376
Organismal Systems	Immune system	hsa04611	Platelet activation	16/456	126/9376	2.61097187412977	COL3A1/FYN/PIK3R1/COL1A1/GNA13/PPP1CB/FCER1G/PLCG2/PIK3R6/RASGRP1/LYN/MAPK1/RAP1B/PRKG1/ITPR1/ADCY3	4.11611970754104
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/456	233/9376	2.1179128077705	COL3A1/COL1A1/ATP1B3/LMNB1/EMD/COL6A1/ITGA4/CAPZA1/NID1/DCN/FMNL1/ITGA1/MYH9/COL6A3/SPTBN1/LAMA2/ELN/FN1/DIAPH1/COL5A2/FBLN1/COL4A2/FBLN2/FBN1	3.90685384669637
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/456	60/9376	3.42690058479532	IGF1/GNA13/BRAF/PPP2CA/LYN/MAPK1/PRKG1/GNA12/ITPR1/PRKCB	4.26381648080478
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/456	50/9376	3.70105263157895	HLA-DRB5/HLA-DRA/HLA-DQA1/CXCR4/HLA-DQA2/HLA-DRB1/ITGA4/TGFB1/MAP3K14	4.329681756635
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/456	362/9376	1.81758263060967	PIK3R1/COL1A1/IGF1/PIK3AP1/MCL1/GNG2/NFKB1/JAK1/COL6A1/ITGA4/PDGFRA/IL2RB/ITGA1/CDK6/PPP2R2D/COL6A3/YWHAZ/PIK3R6/GNB1/PDGFD/LAMA2/PPP2CA/MAPK1/SOS1/FN1/BCL2L11/LAMB1/PHLPP2/PPP2R5A/COL4A2/GNG4/RPS6KB1	3.58684654785914
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/456	86/9376	2.86903304773562	CBLB/PIK3R1/BRAF/PLCG2/STAT5B/MAPK8/MAPK1/SOS1/ABL1/STAT5A/RPS6KB1/PRKCB	3.9368057060071
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/456	76/9376	2.97599261311173	PIK3R1/IGF1/BRAF/PLCG2/CAMK4/BAX/PDGFRA/CDK6/MAPK1/SOS1/PRKCB	3.91053584348403
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/456	238/9376	1.98702638950317	PIK3R1/IGF1/REL/RALGAPA1/PLAAT2/GNG2/NFKB1/RASA2/PLCG2/STK4/PDGFRA/GNB1/PDGFD/ETS1/MAPK8/RASGRP1/MAPK1/SOS1/ABL1/RAP1B/RASA1/GNG4/PRKCB	3.4872035513689
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	11/456	78/9376	2.89968511021143	SACM1L/PLCG2/IP6K1/SYNJ1/PI4K2B/PIK3C2B/INPP5D/PIP5K1A/IPPK/PI4K2A/PIKFYVE	3.80907725904394
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	13/456	103/9376	2.59512859819452	COL3A1/PIK3R1/COL1A1/NFKB1/ITGB2/LAMA2/ACTN4/TGFB1/FN1/LAMB1/COL4A2/ITGAM/PRKCB	3.68035588328058
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/456	157/9376	2.22639401050397	PIK3R1/ZFP36L2/PPP1CB/NFKB1/NFATC2/HIPK1/FOXO1/CDK6/TRPM7/ETS1/MAPK1/TGFB1/TGFBR2/KIR2DL4/ITPR1/HLA-G/CDK1	3.5036730442278
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/456	158/9376	2.21230290917166	MCM6/STAG2/CDK6/CREBBP/CCNH/YWHAZ/PPP2CA/BUB1B/NIPBL/TGFB1/ABL1/DBF4/PDS5A/DDX11/PPP2R5A/ATRX/CDK1	3.47461724887886
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/456	69/9376	2.97991355199593	FYN/PIK3R1/FCER1G/PLCG2/ALOX5AP/MAPK8/LYN/MAPK1/SOS1/INPP5D	3.73208519415527
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/456	70/9376	2.93734335839599	FYN/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/ITGB2/LAMA2/ABL1/HLA-G	3.6784065434477
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/456	134/9376	2.30164964650432	PRKCH/GNA13/PPP1CB/BRAF/RAMP1/MYH9/CALCRL/EDNRA/MAPK1/PRKG1/GNA12/PRKCQ/ITPR1/ADCY3/PRKCB	3.43122465771582
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/456	109/9376	2.45227748269757	PIK3R1/PPP1CB/OGT/NFKB1/RPS6KA3/GFPT1/FOXO1/OGA/MAPK8/PTPN1/PRKCQ/RPS6KB1/PRKCB	3.44809246570433
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/456	149/9376	2.20793594725068	FYN/PIK3R1/CYTH1/GNA13/FCER1G/PLCG2/PDGFRA/PLPP3/PIK3R6/PDGFD/MAPK1/SOS1/DGKB/GNA12/PIP5K1A/ADCY3	3.36041111075108
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	23/456	250/9376	1.89164912280702	VPS37B/CBLB/CYTH1/ASAP1/CXCR4/WIPF1/CAPZA1/PDGFRA/IL2RB/ITCH/EPS15/RAB11A/WIPF3/BIN1/ARAP1/TGFBR2/PARD6G/AP2B1/PIP5K1A/RAB11FIP1/HLA-G/RABEP1/GBF1	3.23079491834523
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/456	98/9376	2.51772287862513	PIK3R1/PTPRC/ASAP1/PLCG2/PLPP3/BIN1/LYN/MAPK1/INPP5D/PIP5K1A/RPS6KB1/PRKCB	3.41478973281263
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	22/456	238/9376	1.90063393778564	PIK3R1/ISG15/MX1/EIF2AK2/STAT1/NFKB1/JAK1/MX2/PLCG2/RPS29/IFIH1/OAS1/C1R/CFD/IRF9/ADAR/MAPK8/MAPK1/C1S/TRAF3/OAS2/PRKCB	3.18197557809001
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/456	181/9376	2.04478045943588	HLA-DRB5/HLA-DRA/HLA-DQA1/CD74/FCER1G/STAT1/NFKB1/JAK1/HLA-DQA2/HLA-DRB1/ITGB2/BAX/CREBBP/MAPK8/MAPK1/TGFB1/NOD2/ITGAM	3.20903234385597
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	11/456	87/9376	2.59971768501714	PIK3R1/BRAF/BAX/CTNNB1/MAPK8/MAPK1/TGFB1/SOS1/BCL2L11/TGFBR2/RPS6KB1	3.38925404628737
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/456	89/9376	2.54129706288192	PDGFRA/PDGFD/TUBA4A/MAPK1/SOS1/PRKG1/ITPR1/CSNK1D/ADCY3/PRKCB/CDK1	3.30315736037502
Human Diseases	Immune disease	hsa05310	Asthma	6/456	32/9376	3.85526315789474	HLA-DRB5/HLA-DRA/HLA-DQA1/FCER1G/HLA-DQA2/HLA-DRB1	3.65797175866921
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/456	116/9376	2.30429522081065	PIK3R1/RHOH/CXCR4/PLCG2/ITGB2/ITGA4/ITK/CTNNB1/ACTN4/RAP1B/PECAM1/ITGAM/PRKCB	3.19584006154476
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/456	90/9376	2.5130604288499	EML4/PIK3R1/STAT1/NFKB1/NFATC2/JAK1/HIF1A/RASGRP1/MAPK1/PRKCQ/RPS6KB1	3.26098514690122
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/456	201/9376	1.94361525704809	IGF1/REL/NFKB1/RUNX1/ZBTB16/KDM6A/BAX/FOXO1/IL2RB/ZEB1/JMJD1C/TGFBR2/BIRC3/BCL11B/RUNX1T1/NFKBIZ/ITGAM/WT1/NR4A3	3.05756415857309
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	14/456	130/9376	2.21430499325236	COL3A1/PIK3R1/COL1A1/GNG2/NFKB1/GNB1/MAPK8/MAPK1/TGFB1/SOS1/TGFBR2/COL4A2/GNG4/ADCY3	3.15215920983405
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/456	187/9376	1.97917253025612	TNFAIP3/STAT1/NFKB1/NAMPT/JAK1/GABARAPL1/OAS1/TRPM7/NLRP1/IRF9/MAPK8/IFI16/MAPK1/BIRC3/NOD2/TRAF3/OAS2/ITPR1	3.05795810474013
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/456	78/9376	2.63607737291948	TENT4B/CNOT6L/CNOT2/BTG1/DHX36/PAN3/DDX6/BTG3/PABPC1/XRN1	3.28051479780791
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	9/456	67/9376	2.76197957580518	PPP1CB/BRAF/RPS6KA3/CAMK4/CREBBP/MAPK1/RAP1B/ITPR1/PRKCB	3.27244524396575
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/456	119/9376	2.24620374465576	PIK3R1/TNFAIP3/TNFRSF1B/NFKB1/MAP3K8/ITCH/MAPK8/MAPK1/BCL3/BIRC3/NOD2/TRAF3/MAP3K14	3.09323583691461
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/456	106/9376	2.32770605759682	PIK3R1/IGF1/NFKB1/BRAF/PDGFRA/FOXO1/CREBBP/ZEB1/CTNNB1/PDGFD/MAPK1/SOS1	3.10814044450442
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/456	93/9376	2.43199396340313	FYN/PTPRJ/CREBBP/CTNNB1/SNAI2/MAPK1/ACTN4/TGFBR2/RAP1B/PTPN1/HEG1	3.13779176290418
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/456	93/9376	2.43199396340313	PIK3R1/NFKB1/BAX/CDK6/TRAF4/LAMA2/FN1/BIRC3/TRAF3/LAMB1/COL4A2	3.13779176290418
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/456	45/9376	3.19844054580897	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/KLRC1/HLA-G	3.34227761037056
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/456	82/9376	2.50748823277706	HLA-DRB5/HLA-DRA/HLA-DQA1/CD74/HLA-DQA2/HLA-DRB1/PSME2/KLRC1/KIR2DL4/HLA-G	3.09988194963007
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/456	122/9376	2.19096922634455	PIK3R1/ATP1B3/STAT1/KAT2B/PLCG2/HIF1A/FOXO1/CREBBP/MED13/CTNNB1/NCOA2/MAPK1/PRKCB	2.99365217897053
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/456	122/9376	2.19096922634455	PIK3R1/IGF1/STAT1/PLCG2/CREBBP/STAT5B/MAPK8/MAPK1/SOS1/ITPR1/STAT5A/ADCY3/PRKCB	2.99365217897053
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/456	70/9376	2.64360902255639	PIK3R1/BRAF/HIF1A/CREBBP/ETS1/MAPK1/TGFB1/SOS1/RAP1B	3.12069729779172
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/456	137/9376	2.10116532206428	PIK3R1/MCL1/LMNB1/NFKB1/CTSW/BAX/TUBA4A/MAPK8/MAPK1/EIF2AK3/BCL2L11/BIRC3/MAP3K14/ITPR1	2.93552618387933
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/456	83/9376	2.47727753117734	SFMBT2/OGT/JARID2/KDM2B/AUTS2/CREBBP/ASXL2/FOXK2/LCOR/KDM2A	3.05639022737164
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	16/456	168/9376	1.95822890559733	PIK3R1/STAT4/MCL1/STAT1/IL21R/JAK1/IL12RB2/PDGFRA/IL2RB/CREBBP/PIAS1/STAT5B/IRF9/SOS1/IL27RA/STAT5A	2.83352393420551
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/456	99/9376	2.28460038986355	PIK3R1/PRKCH/IGF1/PPP1CB/PLCG2/MAPK8/PRKCQ/ITPR1/PTGER4/ADCY3/PRKCB	2.90514290818646
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/456	73/9376	2.53496755587599	MX1/CXCR4/KAT2B/MX2/CREBBP/ELL2/SERINC3/NUP153/RANBP2	2.97669783978623
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/456	100/9376	2.26175438596491	HLA-DRB5/CD44/HLA-DRA/CD38/HLA-DQA1/HLA-DQA2/HLA-DRB1/MME/ITGA4/ITGA1/ITGAM	2.86800619714452
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	14/456	142/9376	2.0271806276254	CBLB/HERC1/FBXW7/UBA6/ITCH/UBE2K/BIRC6/UBC/PIAS1/UBE2O/UBR5/BIRC3/HERC2/UBE2F	2.78857089066657
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	15/456	157/9376	1.96446530338585	NFATC2/DUSP2/ATP11B/HIF1A/DUSP4/DUSP5/ELMO1/MAPK1/TGFB1/ADAM9/PECAM1/HAVCR2/PTGER4/ATP11C/LRP1	2.75537148471345
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/456	115/9376	2.14553775743707	FYN/PIK3R1/GNG2/CAMK4/PIK3R6/GNB1/MAPK1/KCNQ5/ITPR1/GNG4/ADCY3/PRKCB	2.79457016842975
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/456	39/9376	3.16329284750337	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/HLA-G	3.06076207025643
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/456	89/9376	2.31027005716539	COL1A1/CD44/COL6A1/ITGA4/ITGA1/COL6A3/LAMA2/FN1/LAMB1/COL4A2	2.80804284108106
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/456	133/9376	2.00976124521831	PIK3R1/IGF1/BRAF/GABARAPL1/STK4/FOXO1/CREBBP/MAPK8/MAPK1/TGFB1/SOS1/BCL2L11/TGFBR2	2.65169564100804
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/456	91/9376	2.25949489107384	PIK3R1/PIK3AP1/NFKB1/NFATC2/PLCG2/LYN/MAPK1/SOS1/INPP5D/PRKCB	2.72968029489973
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/456	105/9376	2.15405179615706	TNFAIP3/CCL4/NFKB1/PLCG2/RELB/LYN/BIRC3/TRAF3/MAP3K14/PRKCQ/PRKCB	2.68869966212885
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	12/456	120/9376	2.05614035087719	PIK3R1/NFKB1/BRAF/RPS6KA3/PLCG2/CAMK4/BAX/MAPK8/MAPK1/SOS1/ABL1/RAP1B	2.63260812899377
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	7/456	54/9376	2.66536712150747	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/TG/HLA-G	2.77484001901316
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/456	138/9376	1.93694380879736	PIK3R1/NFKB1/NFATC2/RPS6KA3/ITGA4/WIPF1/WIPF3/ELMO1/MAPK8/MAPK1/FN1/PIP5K1A/FYB1	2.5069734948532
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/456	109/9376	2.07500402382102	PIK3R1/CCL4/STAT1/NFKB1/JAK1/CCL3/MAP3K8/IRF9/MAPK8/MAPK1/TRAF3	2.55234507131101
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/456	169/9376	1.82497664279041	PIK3R1/GABARAPL1/RAB1A/HIF1A/ATG2A/BIRC6/UBC/AMBRA1/PPP2CA/MAPK8/MAPK1/EIF2AK3/PRKCQ/ITPR1/RPS6KB1	2.44687377214035
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/456	200/9376	1.74771929824561	FYN/CYTH1/GNA13/NFKB1/BAX/WIPF1/RAB1A/MYO5B/MYH9/SEC24B/TUBA4A/WIPF3/NCKAP1L/MAPK8/MAPK1/ABL1/GNA12	2.41664310403101
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/456	32/9376	3.21271929824561	BAX/BIRC6/MAPK8/BCL2L11/BIRC3	2.8347876378627
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/456	170/9376	1.81424148606811	PIK3R1/NFE2L2/BRAF/PLCG2/BAX/ARID1B/CDK6/CTNNB1/DPF3/MAPK1/TGFB1/SOS1/TGFBR2/RPS6KB1/PRKCB	2.42229946865903
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/456	44/9376	2.80382775119617	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/HLA-G	2.71156281523399
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/456	71/9376	2.31677786014332	PIK3R1/STAT1/NFKB1/STAT5B/MAPK8/MAPK1/SOS1/STAT5A	2.51807773984389
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/456	99/9376	2.0769094453305	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/ITGB2/C1R/CFD/C1S/ITGAM	2.43544674479916
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/456	73/9376	2.25330449411199	PIK3R1/IGF1/BRAF/BAX/PDGFRA/CDK6/PDGFD/MAPK1	2.4304805439933
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/456	14/9376	4.40601503759398	B4GALT1/B3GNT7/CHST2	2.88344646674805
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/456	36/9376	2.85575048732943	GALNT11/B4GALT5/GALNT3/GALNT13/ST6GALNAC3	2.52222036454455
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/456	212/9376	1.64879179079775	PIK3R1/IGF1/BRAF/SIPA1L1/ITGB2/PDGFRA/CTNNB1/SKAP1/PDGFD/MAPK1/RAP1B/RAPGEF2/PARD6G/ITGAM/ADCY3/PRKCB/FYB1	2.16031145574673
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/456	104/9376	1.97705802968961	PLAAT2/GPCPD1/PLPP3/SGMS1/SELENOI/ETNK1/DGKB/CHKA/CDS2/PTDSS1	2.26535332815612
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/456	62/9376	2.32144878324844	ATXN1/KAT2B/RBPJ/TLE1/ITCH/CREBBP/MAML1	2.36028092017066
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/456	49/9376	2.51772287862513	B4GALT1/GALNT11/OGT/GALNT3/GXYLT1/GALNT13	2.4082699399909
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/456	214/9376	1.63338252172487	PIK3R1/GNG2/TNFRSF1B/NFKB1/NFATC2/CXCR4/PLCG2/BAX/GNB1/MAPK8/MAPK1/ITPR1/HLA-G/GNG4/RPS6KB1/PRKCB/CDK1	2.11915854688502
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/456	50/9376	2.46736842105263	ITGB2/KLRK1/GYPC/TGFB1/PECAM1/LRP1	2.35213420450086
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/456	184/9376	1.67620137299771	FYN/PIK3R1/NFATC2/CXCR4/PLCG2/EPHA4/PLXNC1/SSH1/SEMA5A/SLIT3/MAPK1/ABL1/PARD6G/RASA1/SSH2	2.0944287186238
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/456	122/9376	1.85389703767616	PIK3R1/IGF1/PFKFB3/FOXO1/PPP2R2D/PPP2CA/CAB39/SCD/PPP2R5A/FASN/RPS6KB1	2.14637848813415
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/456	78/9376	2.10886189833558	NFKB1/ITGB2/C1R/MAPK8/MAPK1/C1S/SERPING1/ITGAM	2.22338987533585
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/456	38/9376	2.70544783010157	PIK3R1/IGF1/ATP1B3/MAPK1/PRKCB	2.38171029913239
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	12/456	138/9376	1.78794813119756	CBLB/PIK3R1/PPP1CB/BRAF/PRKAR2A/FOXO1/MAPK8/MAPK1/SOS1/PTPN1/FASN/RPS6KB1	2.10830688210314
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/456	140/9376	1.76240601503759	GNA13/GNG2/RYR2/CAMK4/PIK3R6/GNB1/MEF2D/MAPK1/ITPR1/GNG4/ADCY3/RPS6KB1	2.05491566133325
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/456	110/9376	1.86921850079745	PIK3R1/IGF1/NFKB1/PLCG2/PFKFB3/HIF1A/CREBBP/MAPK1/RPS6KB1/PRKCB	2.073312606831
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/456	157/9376	1.70253659626774	PPP1CB/ITGB2/PPP2R2D/YWHAZ/CTNNB1/PPP2CA/SNAI2/TGFB1/TGFBR2/BIRC3/PARD6G/CSNK1D/LATS2	2.0070699251991
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/456	97/9376	1.90775908844276	GNG2/RYR2/GNB1/MAPK1/PRKG1/ITPR1/GNG4/ADCY3/PRKCB	2.03184941317686
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/456	160/9376	1.67061403508772	HLA-DRB5/PTPRC/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/ITGB2/ITGA4/NLGN1/PECAM1/HLA-G/ITGAM/GLG1	1.93440332067268
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/456	226/9376	1.54665424623506	PIK3R1/ATP1B3/PPP1CB/PDE4B/NFKB1/BRAF/RYR2/CAMK4/CREBBP/PDE4D/EDNRA/ATP2B1/MAPK8/VIPR2/MAPK1/RAP1B/ADCY3	1.88079746516342
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/456	99/9376	1.86921850079745	PIK3R1/IGF1/BRAF/BAX/MAPK8/MAPK1/SOS1/ADCY3/RPS6KB1	1.96575058141186
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/456	102/9376	1.81424148606811	CD38/ATP1B3/RYR2/ATP2B1/RAB11A/RAP1B/ITPR1/ADCY3/PRKCB	1.86941360319597
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/456	72/9376	1.9990253411306	ISG15/RNF125/NFKB1/IFIH1/ADAR/MAPK8/TRAF3	1.92394890577337
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/456	166/9376	1.61023039526527	ATP1B3/GNA13/PPP1CB/NFATC2/PIK3R6/EDNRA/ATP2B1/MEF2D/MAPK1/PRKG1/GNA12/ITPR1/ADCY3	1.79350956473348
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/456	103/9376	1.79662749105774	PPP1CB/GSPT1/PABPN1/PPP2R2D/SMG1/PPP2CA/PAPOLG/PABPC1/PPP2R5A	1.83801649397792
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/456	103/9376	1.79662749105774	COL3A1/COL1A1/ATP1B3/COL6A1/MME/COL6A3/ELN/COL5A2/COL4A2	1.83801649397792
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/456	103/9376	1.79662749105774	PIK3R1/NFKB1/CCL3/PPP2R2D/PPP2CA/MAPK8/MAPK1/TGFB1/TGFBR2	1.83801649397792
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/456	59/9376	2.09099018733274	PIK3R1/BRAF/BAX/CTNNB1/MAPK1/SOS1	1.90061623582521
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/456	253/9376	1.462866652798	PIK3R1/FNBP1/CD44/CYTH1/NFKB1/PLCG2/BAX/FOXO1/UBC/ELMO1/MAPK8/MAPK1/ACTN4/DIAPH1/GLMN/PRKCQ/ITPR1/RPS6KB1	1.68745790840638
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/456	105/9376	1.76240601503759	IGF1/EMD/RYR2/ITGA4/ITGA1/LAMA2/TGFB1/CACNA2D1/ADCY3	1.77624678707021
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/456	90/9376	1.82768031189084	PIK3R1/IGF1/NFKB1/CAMK4/BAX/FOXO1/ADCY3/RPS6KB1	1.78383701800342
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/456	154/9376	1.60218728639781	ATP1B3/CREM/PPP1CB/RYR2/PPP2R2D/PIK3R6/ATP2B1/PPP2CA/MAPK1/PPP2R5A/CACNA2D1/ADCY3	1.70358974105747
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/456	138/9376	1.63895245359776	IGF1/PPP1CB/RPS6KA3/YWHAZ/PPP2CA/MAPK1/PPP2R5A/ITPR1/ADCY3/PGR/CDK1	1.70964026935308
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/456	91/9376	1.80759591285907	PDE7A/GNG2/PDE4B/PDE4D/GNB1/GNG4/ADCY3/PRKCB	1.75028788540257
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/456	21/9376	2.93734335839599	CHST11/CHST12/CHSY1	2.00946285209845
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/456	34/9376	2.41898864809082	RORA/RORB/BHLHE40/CSNK1D	1.87406254309545
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/456	110/9376	1.6822966507177	PIK3R1/IGF1/BRAF/RPS6KA3/MAPK8/MAPK1/ADCY3/PGR/CDK1	1.62745529027945
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/456	95/9376	1.731486611265	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/ITGB2/CCL3/TGFB1	1.62015449515845
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/456	144/9376	1.57066276803119	PIK3R1/ATXN1/RORA/ATG2A/RBPJ/PUM2/AMBRA1/PUM1/MAPK8/ITPR1/PRKCB	1.56026554840337
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/456	37/9376	2.22285443338075	BRAF/BAX/CTNNB1/MAPK1	1.68504331475384
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/456	99/9376	1.6615275562644	IGF1/EMD/RYR2/ITGA4/ITGA1/LAMA2/TGFB1/CACNA2D1	1.49605441802456
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/456	133/9376	1.54597018862947	PPP1CB/GNG2/PPP2R2D/GNB1/PPP2CA/MAPK8/PPP2R5A/ITPR1/GNG4/PRKCB	1.43375156866522
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/456	53/9376	1.93975504799735	ATP1B3/ATP2B1/RAB11A/AP2B1/PRKCB	1.55117355561163
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/456	168/9376	1.46867167919799	STAT4/TNFAIP3/EIF2AK2/STAT1/JAK1/BAX/TRPM7/STAT5B/IRF9/MAPK8/BIRC3/STAT5A	1.38588223809005
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/456	86/9376	1.67360261117911	EMD/RYR2/ITGA4/ITGA1/CTNNB1/LAMA2/CACNA2D1	1.41883130770961
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/456	170/9376	1.45139318885449	RUNX1/RAB8B/MYH9/PPP2R2D/TUBA4A/PPP2CA/MAPK8/ACTN4/RAPGEF2/PARD6G/ARHGAP17/YBX3	1.34285651152276
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/456	154/9376	1.46867167919799	CD38/PPP1CB/NFATC2/RYR2/CAMK4/PIK3R6/MAPK1/CACNA2D1/ITPR1/ADCY3/PRKCB	1.32587366528764
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/456	155/9376	1.45919637804188	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/ITGB2/C1R/TUBA4A/HLA-G/ITGAM/PIKFYVE	1.30334960386115
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/456	88/9376	1.63556618819777	A2M/ITGB2/C1R/CFD/C1S/SERPING1/ITGAM	1.3543367086065
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/456	105/9376	1.56658312447786	USP15/GABARAPL1/HIF1A/UBC/AMBRA1/CCZ1/MAPK8/EIF2AK3	1.32002034954089
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/456	89/9376	1.61718904001577	GNG2/SLC38A1/GABARAPL1/GNB1/GNG4/ADCY3/PRKCB	1.32269928319916
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	16/456	248/9376	1.32654216185625	CYTH1/RHOH/PTPRC/NFKB1/BAX/CTNNB1/TUBA4A/NCKAP1L/ELMO1/MAPK8/MAPK1/PIK3C2B/BIRC3/EXOC4/KLC1/FLNA	1.17831910882544
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/456	75/9376	1.64491228070175	PIK3R1/BAX/REV3L/MAPK1/BIRC3/TOP2A	1.26780391601382
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/456	15/9376	2.74152046783626	ST3GAL5/ST6GALNAC3	1.52615527556053
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/456	60/9376	1.71345029239766	PIK3R1/NFATC2/PLCG2/MAPK1/PRKCB	1.2534593027908
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/456	93/9376	1.54763252216563	CD38/ATP1B3/ATP2B1/PRKG1/ITPR1/ADCY3/PRKCB	1.19997490287325
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/456	110/9376	1.49537480063796	DCN/CREBBP/PPP2CA/MAPK1/TGFB1/TGFBR2/RPS6KB1/FBN1	1.18159797372791
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/456	216/9376	1.33268356075374	PIK3R1/NFE2L2/NFKB1/NFATC2/CCL3/BAX/ABCG1/MAPK8/LYN/MAPK1/EIF2AK3/RAP1B/TRAF3/ITPR1	1.11839730589025
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/456	94/9376	1.53116834639791	JUND/TNFAIP3/NFKB1/TRAF4/MAPK8/MAPK1/TRAF3	1.17020234367558
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/456	62/9376	1.65817770232032	PIK3R1/IGF1/FOXO1/ADCY3/RPS6KB1	1.1755917388259
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/456	148/9376	1.38928402086297	PIK3R1/IGF1/BRAF/BAX/CDK6/CTNNB1/MAPK1/SOS1/PGR/RPS6KB1	1.07926793528192
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/456	63/9376	1.63185742133111	KMT2E/SETD2/KMT2C/NSD3/PHYKPL	1.13770638742369
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/456	98/9376	1.46867167919799	ATP1B3/NR4A2/CAMK4/ATP2B1/ITPR1/ADCY3/PRKCB	1.05448449168477
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/456	32/9376	1.92763157894737	GABARAPL1/ATG2A/PPP2CA	1.18841939624967
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/456	116/9376	1.41802782819117	GNG2/SLC38A1/GNB1/MAPK1/ITPR1/GNG4/ADCY3/PRKCB	1.02426970432627
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/456	100/9376	1.43929824561404	TNFRSF1B/CCL4/CXCR4/XCL2/CCL3/XCL1/IL2RB	0.998538308905711
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/456	83/9376	1.4863665187064	CCL4/NFKB1/POLR3E/ADAR/IFI16/GSDME	1.00626039679241
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/456	19/9376	2.16435826408126	HPSE2/HGSNAT	1.14863156838461
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	10/456	158/9376	1.30135465245392	PIK3R1/IGF1/BRAF/RPS6KA3/RICTOR/MAPK1/SOS1/CAB39/RPS6KB1/PRKCB	0.863721488684486
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/456	217/9376	1.23178915029509	PIK3R1/NFKB1/KPNA2/RPS6KA3/STAT5B/MAPK1/SOS1/KPNA6/STAT5A/ADCY3/PGR/RPS6KB1/PRKCB	0.781060316701156
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/456	71/9376	1.44798616258957	NFKB1/PLCG2/MAPK8/LYN/MAP3K14	0.856685108338708
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	5/456	71/9376	1.44798616258957	PIK3R1/PDGFRA/HIF1A/MAPK1/SLC16A3	0.856685108338708
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/456	144/9376	1.28508771929825	NFKB1/TRA2A/FOXO1/CTNNB1/MAPK8/SCD/TRAF3/MAP3K14/FASN	0.779466563463679
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/456	54/9376	1.5230669265757	FANCA/REV3L/RPA1/WDR48	0.871535784356454
NA	NA	hsa04081	Hormone signaling	13/456	219/9376	1.22053993431066	PIK3R1/IGF1/GNA13/GNG2/RAMP1/STAT5B/GNB1/VIPR2/PRKG1/GNA12/STAT5A/GNG4/ADCY3	0.746652156114974
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/456	55/9376	1.49537480063796	B4GALT5/PLPP3/CERS6/SGMS1	0.833047247327321
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/456	38/9376	1.62326869806094	CD38/NAMPT/NADSYN1	0.870413888421421
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/456	56/9376	1.46867167919799	NFKB1/ITGB2/RAB1A/ITGAM	0.795317246984071
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/456	205/9376	1.20359435173299	COL3A1/PIK3R1/COL1A1/PPP1CB/NFKB1/GFPT1/RYR2/UQCRB/MAPK8/TGFB1/TGFBR2/PRKCB	0.666376911731604
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/456	93/9376	1.32654216185625	MAPK8/MAPK1/SOS1/ITPR1/ADCY3/PRKCB	0.715520687865517
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/456	75/9376	1.37076023391813	ATP1B3/TG/ITPR1/ADCY3/PRKCB	0.728860793210701
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/456	150/9376	1.23368421052632	PIK3R1/BRAF/BAX/CTNNB1/MAPK1/TGFB1/SOS1/TGFBR2/RPS6KB1	0.652309804036023
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/456	323/9376	1.14583672804302	PIK3R1/CD44/ZEB2/MCL1/NFKB1/PLCG2/PDGFRA/CDK6/CREBBP/ZEB1/TIMP3/MAPK1/SOS1/ABL1/BCL2L11/PDCD4/KIF23/PRKCB	0.603055864751112
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/456	227/9376	1.17752531107504	PIK3R1/NFE2L2/PTPRJ/NFKB1/BRAF/HIF1A/UQCRB/MAPK8/MAPK1/SOS1/ABL1/PTPN1/MAP3K14	0.61216998128516
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/456	59/9376	1.39399345822183	PIK3R1/PLAAT2/PRKG1/ADCY3	0.686376809067431
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/456	115/9376	1.25156369183829	GNG2/BRAF/GNB1/MAPK1/ITPR1/GNG4/PRKCB	0.613696392028321
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	14/456	254/9376	1.1333057052079	CD38/NFATC2/CXCR4/PLCG2/RYR2/MCOLN2/CAMK4/PDGFRA/EDNRA/ATP2B1/PDGFD/ITPR1/ADCY3/PRKCB	0.48697446979566
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	9/456	157/9376	1.17867918203151	PIK3R1/NFKB1/BAX/ITCH/UQCRB/MAPK8/EIF2AK3/TGFB1/BCL2L11	0.51046680617041
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/456	178/9376	1.15513502858269	TBL1X/NFATC2/APCDD1/TLE1/CREBBP/CTNNB1/SFRP4/MAPK8/TBL1XR1/PRKCB	0.472453206571455
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/456	27/9376	1.5230669265757	ELOVL5/SCD	0.615378324590531
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/456	65/9376	1.26531713900135	PIK3R1/MAPK1/ITPR1/PRKCB	0.48529906307149
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/456	143/9376	1.15028830818304	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DQA2/HLA-DRB1/C1R/ACTN4/C1S	0.409456178558438
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/456	28/9376	1.46867167919799	B4GALT1/ST3GAL4	0.561531349092211
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/456	47/9376	1.31243001119821	PIK3R1/MAPK8/MAPK1	0.485478229192045
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/456	48/9376	1.28508771929825	PIK3R1/ATP1B3/PRKCB	0.447703502471396
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/456	108/9376	1.14230019493177	NUP98/KPNA2/IPO9/KPNA6/NUP153/RANBP2	0.336286933111878
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/456	149/9376	1.10396797362534	GNG2/GNB1/MAPK8/MAPK1/ITPR1/GNG4/ADCY3/PRKCB	0.289233162178887
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/456	70/9376	1.1749373433584	TNFRSF1B/NFKB1/MAPK8/PRKCQ	0.332151069511836
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/456	12/9376	1.71345029239766	NPC1	0.5591254659961
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/456	51/9376	1.20949432404541	PLAAT2/PLPP3/SELENOI	0.339170882188629
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/456	52/9376	1.18623481781377	APOE/NPC1/LRP1	0.304471782773519
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/456	34/9376	1.20949432404541	POLR2J3/POLR3E	0.276679779089729
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/456	75/9376	1.0966081871345	IGF1/BAX/CDK6/CDK1	0.189917670407583
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/456	76/9376	1.08217913204063	ATP1B3/ITPR1/ADCY3/PRKCB	0.162634434612186
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/456	139/9376	1.0354663637511	PIK3R1/NCOA2/MAPK1/SOS1/ITPR1/ADCY3/PGR	0.0952454470637915
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/456	36/9376	1.14230019493177	MCM6/RPA1	0.193405553163605
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/456	57/9376	1.08217913204063	ELOVL5/SCD/FASN	0.14070189749396
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	4/456	78/9376	1.05443094916779	PIK3R1/CTNNB1/ELMO1/FN1	0.10914003039174
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/456	101/9376	1.01789126281049	CREBBP/CTNNB1/MAPK1/ADCY3/PRKCB	0.0408724202717604
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/456	144/9376	0.999512670565302	PIK3R1/IGF1/JARID2/KAT6A/JAK1/CTNNB1/MAPK1	-0.0013324214760064
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	12/456	250/9376	0.986947368421053	LITAF/CTSW/MCOLN2/BORCS5/OSBPL7/NPC1/GGA2/HGSNAT/LAMP3/AP2B1/CLN8/PIKFYVE	-0.0472948099175358
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/456	17/9376	1.20949432404541	MYH9	0.195464381785669
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/456	61/9376	1.01121656600518	ATP1B3/ATP2B1/TRPM7	0.019870968576791
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/456	191/9376	0.968861945439515	PPP1CB/GNG2/BRAF/CAMK4/HDAC9/GNB1/MAPK1/SOS1/GNG4	-0.0983001568787133
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/456	18/9376	1.14230019493177	FASN	0.136626788308287
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/456	63/9376	0.979114452798663	RPA1/POLR2J3/CCNH	-0.0376059845997252
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/456	41/9376	1.00299529311083	RPA1/RBBP8	0.00434569985134604
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/456	41/9376	1.00299529311083	BRAF/MAPK1	0.00434569985134604
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/456	86/9376	0.956344349245206	ATP1B3/RYR2/ADCY3/PRKCB	-0.0919533312688846
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/456	87/9376	0.945351885460778	ATP1B3/RYR2/UQCRB/CACNA2D1	-0.115780643709048
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/456	155/9376	0.928579513299377	BRAF/CDK6/CTNNB1/MAPK1/RAP1B/ITPR1/ADCY3	-0.202714715315845
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/456	44/9376	0.934609250398724	B4GALT1/ALG13	-0.0982971489165284
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/456	44/9376	0.934609250398724	RAB11A/ADCY3	-0.0982971489165284
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/456	69/9376	0.893974065598779	EDNRA/ITPR1/PTGER4	-0.199856109665179
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/456	69/9376	0.893974065598779	PPP1CB/CAMK4/PRKCB	-0.199856109665179
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/456	46/9376	0.893974065598779	PSME4/PSME2	-0.162980570947708
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/456	23/9376	0.893974065598779	B4GALT1	-0.115102880385693
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/456	23/9376	0.893974065598779	RPA1	-0.115102880385693
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/456	23/9376	0.893974065598779	MME	-0.115102880385693
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/456	23/9376	0.893974065598779	ATP1B3	-0.115102880385693
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/456	142/9376	0.868791697553743	PIK3R1/NFE2L2/NFKB1/CTNNB1/MAPK8/PECAM1	-0.356201862627845
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/456	298/9376	0.896973978570588	TNFRSF1B/CCL4/IL21R/CXCR4/XCL2/IL12RB2/RELL1/CCL3/XCL1/IL2RB/TGFB1/IL27RA/TGFBR2	-0.408644449235055
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/456	24/9376	0.85672514619883	EXT1	-0.158894541477532
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	17/456	388/9376	0.900886236209079	PIK3R1/EIF2AK2/NFKB1/BRAF/MME/APOE/ATG2A/CTNNB1/UQCRB/AMBRA1/TUBA4A/MAPK8/MAPK1/EIF2AK3/ITPR1/KLC1/LRP1	-0.450820785954369
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/456	51/9376	0.806329549363605	PLCG2/ADCY3	-0.313552063501147
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/456	76/9376	0.811634349030471	FABP5/UBC/SCD	-0.372780052369506
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/456	26/9376	0.790823211875843	PLAAT2	-0.241479346057571
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/456	52/9376	0.790823211875843	IGF1/ADCY3	-0.34197917630359
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/456	194/9376	0.847892928196781	BICDL1/CAPZA1/MYO5B/MYH9/TUBA4A/KIF23/KLC1/MYO9B	-0.48402440409709
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/456	195/9376	0.843544759334233	PIK3R1/NFKB1/PLCG2/ITGB2/HDAC9/MAPK1/ITGAM/PRKCB	-0.499169520518539
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/456	27/9376	0.761533463287849	OXCT1	-0.280551360403385
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/456	28/9376	0.734335839598997	ELOVL5	-0.318301192533553
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/456	56/9376	0.734335839598997	B4GALT1/ALG13	-0.450821541071185
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/456	29/9376	0.709013914095584	LATS2	-0.354830328047129
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/456	29/9376	0.709013914095584	GNB1	-0.354830328047129
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/456	107/9376	0.768650598458764	FOXO1/CREBBP/SIK2/ITPR1	-0.544163565871549
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/456	30/9376	0.685380116959064	PGAP1	-0.390228996077859
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/456	30/9376	0.685380116959064	PLAAT2	-0.390228996077859
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/456	30/9376	0.685380116959064	NFKB1	-0.390228996077859
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/456	59/9376	0.696996729110913	CTPS1/NT5C3A	-0.527862617690348
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/456	275/9376	0.822456140350877	FYN/PIK3R1/RYR2/BAX/UQCRB/TUBA4A/MAPK8/MAPK1/EIF2AK3/ITPR1/KLC1	-0.675636461769635
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/456	32/9376	0.642543859649123	B4GALT1	-0.45794884536335
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/456	33/9376	0.623072833599149	VAMP1	-0.490407233609034
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/456	63/9376	0.652742968532442	PLAAT2/PTGDS	-0.625262170611433
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/456	63/9376	0.652742968532442	BAX/CTNNB1	-0.625262170611433
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/456	35/9376	0.587468671679198	PFKFB3	-0.552815108274422
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/456	117/9376	0.702953966111861	BAZ1A/ARID1B/DPF3/GATAD2B	-0.731004885189125
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/456	65/9376	0.632658569500675	PLPP3/DGKB	-0.671914572574056
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/456	65/9376	0.632658569500675	ITPR1/ADCY3	-0.671914572574056
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/456	36/9376	0.571150097465887	GYG1	-0.582866050630042
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/456	37/9376	0.555713608345187	GFPT1	-0.612208447430922
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/456	37/9376	0.555713608345187	GFPT1	-0.612208447430922
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/456	37/9376	0.555713608345187	PRKCB	-0.612208447430922
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/456	38/9376	0.541089566020314	GFPT1	-0.64088252228955
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/456	38/9376	0.541089566020314	PTPRC	-0.64088252228955
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	19/456	480/9376	0.813888888888889	ATXN1/TNFRSF1B/NFKB1/BRAF/RYR2/BAX/RAB1A/ATG2A/UBC/CTNNB1/UQCRB/AMBRA1/TUBA4A/MAPK8/MAPK1/EIF2AK3/ITPR1/KLC1/PRKCB	-0.946414021354918
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/456	174/9376	0.709013914095584	NFE2L2/BAX/DNAJC1/SEC24B/MAPK8/EIF2AK3	-0.875974300262284
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/456	128/9376	0.642543859649123	PDE7A/PDE4B/PDE4D/ADCY3	-0.920639211752541
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/456	42/9376	0.489557226399332	PCBP2	-0.749589404439772
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/456	43/9376	0.478172174622603	PLPP3	-0.775419039598749
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/456	44/9376	0.467304625199362	CCNH	-0.800762139954158
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	11/456	308/9376	0.734335839598997	BAX/ATG2A/CREBBP/POLR2J3/UQCRB/AMBRA1/TUBA4A/MAPK8/AP2B1/ITPR1/KLC1	-1.07186034640334
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/456	235/9376	0.699962672639044	RPS6KA3/ARID1B/UQCRB/DPF3/SOS1/PRKG1/ADCY3/RPS6KB1	-1.0531688304439
NA	NA	hsa04519	Cadherin signaling	15/456	404/9376	0.763418447107869	PPP1CB/NFKB1/LHFPL3/KRT86/KRT81/PDGFRA/CREBBP/YWHAZ/CTNNB1/NCKAP1L/MAPK8/CDH11/MAPK1/ACTN4/LATS2	-1.09903762508726
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/456	45/9376	0.45692007797271	ABCG1	-0.825641551914559
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/456	48/9376	0.428362573099415	OXCT1	-0.89770292034008
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	9/456	268/9376	0.690494893951296	NFE2L2/BAX/UBC/UQCRB/TUBA4A/MAPK8/EIF2AK3/ITPR1/KLC1	-1.16227617788988
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/456	49/9376	0.419620479770856	NFKB1	-0.920926061034499
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	13/456	368/9376	0.726353928299008	TNFRSF1B/NUP98/BAX/RAB1A/ATG2A/UQCRB/AMBRA1/TUBA4A/EIF2AK3/NUP153/RANBP2/SRSF7/KLC1	-1.21083389855064
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/456	85/9376	0.483797729618163	CTPS1/NT5C3A	-1.08089566606091
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/456	90/9376	0.45692007797271	ATP1B3/ADCY3	-1.17045923979217
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/456	56/9376	0.367167919799499	CSNK1D	-1.07389093509881
NA	NA	hsa04382	Cornified envelope formation	6/456	217/9376	0.568518069366966	KRT86/KRT81/PPP2R2D/PPP2CA/PPP2R5A/COL4A2	-1.45396543782144
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/456	68/9376	0.302373581011352	ALDH1A3	-1.30537358510618
NA	NA	hsa04082	Neuroactive ligand signaling	5/456	199/9376	0.51661817861236	GNG2/GNB1/GNG4/ADCY3/PRKCB	-1.55830375974266
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/456	79/9376	0.260270930490784	AP2B1	-1.49279595030215
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/456	138/9376	0.297991355199593	UQCRB/PPA1	-1.87835924539748
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/456	183/9376	0.337072188668392	XRN1/MDN1/TCOF1	-2.04761728120244
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/456	154/9376	0.267031214399635	CTPS1/NADSYN1	-2.0735710166409
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/456	370/9376	0.44457088667615	NR3C1/P2RY8/CALCRL/EDNRA/GPR35/VIPR2/S1PR5/PTGER4	-2.46461542951115
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/456	243/9376	0.253844487762616	TRA2A/SRSF10/SRSF7	-2.66447341881408
Genetic Information Processing	Translation	hsa03010	Ribosome	1/456	222/9376	0.0926189347241979	RPS29	-3.09347334265403
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/456	449/9376	0.183175086937835	GNB1/OR11G2/PRKG1/ADCY3	-4.01037524354684