category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/504	82/9376	3.85675571041425	B2M/HLA-A/HLA-DRA/TAP1/CANX/CD74/HLA-DMA/HLA-C/TAP2/HSP90AA1/HLA-F/KLRC1/CREB1/HSPA5/CTSL/PSME3/HSP90AB1	6.192540222466
NA	NA	hsa04518	Integrin signaling	24/504	154/9376	2.89919604205318	COL1A1/IGF1/COL6A1/COL1A2/COL6A3/PDGFRA/COL6A2/LAMA2/ACTB/FN1/COL4A1/AKT3/FBN1/LAMB1/C3/ITGA9/COL4A2/COL4A5/PDGFRB/ITGAE/IGF1R/PIK3R1/ITGB8/ITGB1	5.66379776616134
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/504	233/9376	2.47510048368417	COL3A1/COL1A1/CSRP2/COL6A1/DCN/COL1A2/COL6A3/NID1/VIM/COL6A2/LAMA2/ACTB/FN1/COL4A1/COL5A2/FBLN1/ELN/VCAN/COL5A1/FBN1/ITGA9/ANK3/COL4A2/TPM2/COL4A5/ENO1/TMOD1/MYL9/DMD/ITGB8/ITGB1	5.43432172210011
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	30/504	224/9376	2.49149659863946	B2M/HLA-A/HLA-DRA/NRP1/CANX/HLA-DMA/HLA-C/AKT3/SMAD4/IL15/MAP2K4/HLA-F/ADCY3/PPP3CA/PTEN/IL1R1/CREB1/BCL2L1/CREB3L1/ANAPC13/IL2RB/MAP3K1/PPP3CB/MYC/CDKN2A/GPS2/PIK3R1/CDC27/ETS1/IKBKG	5.38490952157452
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	28/504	203/9376	2.56595511767926	COL1A1/IGF1/COL6A1/COL1A2/COL6A3/PDGFRA/COL6A2/LAMA2/ACTB/FN1/COL4A1/BIRC3/PRKCA/PIP5K1B/AKT3/LAMB1/ITGA9/COL4A2/COL4A5/PDGFRB/PTEN/IGF1R/EMP1/PIK3R1/MYL9/VASP/ITGB8/ITGB1	5.37603110109512
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	30/504	227/9376	2.45856933081603	B2M/HLA-A/TAP1/CCL4/PDGFRA/GNG11/CCL3/GNB2/CXCL8/PRKCA/HLA-C/TAP2/AKT3/IL1B/CALM2/PTGER2/HLA-F/GNAI2/ADCY3/PPP3CA/IL1R1/CREB1/CREB3L1/PPP3CB/MYC/CDKN2A/PIK3R1/ITPR2/IKBKG/ITPR3	5.30204405645313
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	25/504	180/9376	2.58377425044092	B2M/HLA-A/BST2/HLA-DRA/TAP1/BIRC3/CD74/HLA-DMA/HLA-C/TAP2/IFNGR1/AKT3/IRF9/C3/IL1B/OAS2/PTPN11/HLA-F/BCL2L1/MAP3K7/PIK3R1/SRSF9/STAT1/IKBKG/EIF2B4	5.11352270784587
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	37/504	333/9376	2.06701940035273	COL1A1/HLA-A/COL6A1/ISG15/COL1A2/COL6A3/COL6A2/LAMA2/FN1/COL4A1/ATP6V0E1/MX1/ATP6V0B/HLA-C/AKT3/IRF9/LAMB1/ITGA9/COL4A2/TCF7L2/COL4A5/PDGFRB/RBPJ/HLA-F/PTEN/PPP2CB/CREB1/CREB3L1/FZD5/MAML2/PPP2R5E/PIK3R1/ITGB8/HEY1/ITGB1/STAT1/IKBKG	4.72528825702648
Organismal Systems	Digestive system	hsa04978	Mineral absorption	12/504	61/9376	3.65964090554254	MT2A/MT1X/MT1F/MT1E/SLC40A1/TRPM6/MT1H/MT1A/MT1G/MT1M/SLC8A1/HMOX2	4.966913898535
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/504	103/9376	2.88981353059023	COL3A1/COL1A1/COL6A1/MME/COL1A2/COL6A3/COL6A2/COL4A1/COL5A2/ELN/COL5A1/COL15A1/COL4A2/SLC8A1/COL4A5/SLC3A1	4.59639746459938
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	16/504	103/9376	2.88981353059023	COL3A1/COL1A1/COL1A2/LAMA2/FN1/COL4A1/CXCL8/PRKCA/LAMB1/IL1B/PRDX1/COL4A2/COL4A5/CXCL3/IL1R1/PIK3R1	4.59639746459938
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	37/504	362/9376	1.90142944839077	COL1A1/IGF1/COL6A1/COL1A2/COL6A3/PDGFRA/GNG11/COL6A2/GNB2/LAMA2/FN1/COL4A1/PRKCA/HSP90AA1/AKT3/FGF10/LAMB1/ITGA9/COL4A2/COL4A5/PDGFRB/PHLPP1/PTEN/PPP2CB/CREB1/BCL2L1/CREB3L1/IL2RB/IGF1R/MYC/PPP2R5E/PIK3R1/YWHAZ/ITGB8/HSP90AB1/ITGB1/IKBKG	4.16886076057845
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/504	196/9376	2.2779397473275	HLA-A/GNG11/GNB2/CXCL8/HLA-C/IFNGR1/AKT3/IRF9/C3/CALM2/TCF7L2/MAP2K4/CXCL3/HLA-F/PPP3CA/CREB1/PPP3CB/MYC/CLEC2B/PIK3R1/ITPR2/STAT1/IKBKG/ITPR3	4.30930479881112
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/504	85/9376	3.0640522875817	UCK2/CDA/NME1/RRM1/GMPR/NME7/DCTPP1/NT5C3B/TYMP/AK2/HPRT1/UCK1/AK6/TK2	4.55605614716217
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/504	130/9376	2.57582417582418	COL3A1/COL1A1/COL1A2/GNG11/GNB2/COL4A1/PRKCA/AKT3/COL4A2/COL4A5/MAP2K4/GNAI2/ADCY3/CREB1/CREB3L1/MMP2/PIK3R1/ACTA2	4.31213779619586
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/504	204/9376	2.18860877684407	COL1A1/IGF1/HPSE2/DCN/COL1A2/ACTB/TIMP3/FN1/PRKCA/AKT3/ANK3/TWIST2/PTPN11/CD63/FZD5/MMP2/IGF1R/MYC/CTSL/PIK3R1/ITPR2/LUM/ITGB1/ITPR3	4.09083660477731
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/504	89/9376	2.92634207240949	COL1A1/COL6A1/COL1A2/COL6A3/COL6A2/LAMA2/FN1/COL4A1/LAMB1/ITGA9/COL4A2/COL4A5/ITGB8/ITGB1	4.35191926966526
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/504	101/9376	2.76284771334276	COL3A1/COL1A1/COL1A2/FN1/COL4A1/CXCL8/PRKCA/AKT3/SMAD4/IL1B/COL4A2/COL4A5/MMP2/PIK3R1/STAT1	4.24530272289738
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/504	71/9376	3.14419852448021	LDHB/PDGFRA/LDHA/AKT3/IDH2/IDH1/PDGFRB/PTEN/PDHB/MYC/NTRK3/PIK3R1	4.32241158262007
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/504	93/9376	2.80047789725209	LAMA2/FN1/COL4A1/BIRC3/AKT3/LAMB1/COL4A2/COL4A5/PTEN/BCL2L1/MYC/PIK3R1/ITGB1/IKBKG	4.15886892782327
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/504	106/9376	2.63252470799641	IGF1/ZEB1/PDGFRA/HSP90AA1/AKT3/TCF7L2/PDGFRB/PTEN/CREB1/CREB3L1/ETV5/IGF1R/PIK3R1/HSP90AB1/IKBKG	4.02868181675939
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	19/504	155/9376	2.28038914490527	HLA-A/HLA-DRA/TAP1/ACTB/C1R/CANX/ATP6V0E1/ATP6V0B/HLA-DMA/HLA-C/TAP2/C3/LAMP2/SEC61G/HLA-F/DYNC1LI1/VAMP3/CTSL/ITGB1	3.83097185602831
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/504	134/9376	2.36010424070126	CALCRL/PLA2G10/RAMP1/EDNRA/PRKCA/PRKG1/CACNA1D/KCNMB4/CALM2/PLA2G4D/CALD1/ADCY3/MYL9/ITPR2/PLA2G12A/ACTA2/ITPR3	3.77947739047608
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/504	78/9376	2.86202686202686	SERPING1/C1S/C1R/CXCL8/C3/IL1B/CALM2/C1QA/C4BPA/C1QB/GNAI2/ITGB1	3.93576004182414
Organismal Systems	Endocrine system	hsa04924	Renin secretion	11/504	69/9376	2.96572348746262	EDNRA/CACNA1D/CALM2/PTGER2/GNAI2/PPP3CA/CREB1/PPP3CB/ITPR2/KCNJ2/ITPR3	3.90600014550661
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/504	59/9376	3.15308044121603	UCK2/CDA/NME1/RRM1/NME7/DCTPP1/NT5C3B/TYMP/UCK1/TK2	3.95401537511502
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/504	105/9376	2.48042328042328	AKT3/IRF9/IL1B/CALM2/PTPN11/FCER1G/PPP3CA/CLEC4E/PPP3CB/PIK3R1/ITPR2/STAT1/IKBKG/ITPR3	3.6358621148471
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/504	205/9376	1.99643825009679	B2M/HLA-A/HLA-DRA/TAP1/ISG15/VIM/HLA-DMA/HLA-C/TAP2/AKT3/IRF9/OAS2/MAP2K4/RBPJ/HLA-F/MAP3K7/TNFAIP3/MYC/PIK3R1/PSMD11/STAT1/IKBKG	3.43802566212775
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	17/504	142/9376	2.22714062150682	ACTB/NQO1/HSP90AA1/AKT3/IL1B/CALM2/SUMO2/KEAP1/MAP2K4/IL1R1/MAP3K7/MMP2/MAP2K5/CTSL/PIK3R1/HSP90AB1/IKBKG	3.51183181979487
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/504	109/9376	2.38939857288481	HLA-DRA/HLA-DMA/IFNGR1/HSP90AA1/SMAD4/RORA/IL1B/PPP3CA/IL1R1/IL2RB/PPP3CB/HSP90AB1/STAT1/IKBKG	3.47744809027334
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/504	86/9376	2.59579180509413	CTNNA2/LAMA2/ACTB/CACNA2D1/CACNA1D/ITGA9/SLC8A1/TCF7L2/GJA1/DMD/ITGB8/ITGB1	3.54329848857546
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/504	75/9376	2.72846560846561	CANX/PRKCA/GPX3/ADCY3/CREB1/CREB3L1/GPX2/HSPA5/ITPR2/DUOX1/ITPR3	3.58192668214895
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/504	54/9376	3.1005291005291	LDHB/SMS/BCAT1/LDHA/ADI1/MAT2A/GCLM/KYAT3/SDSL	3.68944612582344
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	13/504	98/9376	2.46776805960479	MARCKSL1/PLPP1/PRKCA/PIP5K1B/AKT3/PLPP3/PLA2G4D/ARF6/GSN/PTPRC/PIK3R1/VASP/MYO10	3.48123568196447
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/504	45/9376	3.30723104056437	HLA-A/HLA-DRA/GZMB/HLA-DMA/HLA-C/IL1B/HLA-F/KLRC1	3.69762945693466
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/504	214/9376	1.9124758937843	B2M/HLA-A/BST2/TAP1/GNG11/GNB2/PRKCA/HLA-C/TAP2/AKT3/CALM2/HLA-F/GNAI2/PPP3CA/BCL2L1/MAP3K7/AP1S2/PPP3CB/PIK3R1/ITPR2/IKBKG/ITPR3	3.21827597146209
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/504	112/9376	2.32539682539683	HLA-DRA/LAMA2/BIRC3/HLA-DMA/IFNGR1/AKT3/LAMB1/GNAI2/BCL2L1/MAP3K7/ITGB1/ALOX5/STAT1/IKBKG	3.3631466413915
Organismal Systems	Immune system	hsa04611	Platelet activation	15/504	126/9376	2.21466364323507	COL3A1/COL1A1/COL1A2/ACTB/PRKG1/AKT3/PLA2G4D/GNAI2/ADCY3/FCER1G/PIK3R1/VASP/ITPR2/ITGB1/ITPR3	3.27160285580139
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/504	103/9376	2.34797349360456	CCL3/CXCL8/IFNGR1/AKT3/C3/IL1B/C1QA/MAP2K4/C1QB/GNAI2/PPP2CB/PIK3R1/IKBKG	3.27853613494665
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/504	166/9376	2.01721170395869	EDNRA/PRKG1/AKT3/CACNA1D/KCNMB4/CALM2/SLC8A1/GNAI2/ADCY3/PPP3CA/CREB1/CREB3L1/PPP3CB/MYL9/VASP/ITPR2/ADRA2C/ITPR3	3.15156099811435
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/504	80/9376	2.55793650793651	IGF1/PDGFRA/PRKCA/AKT3/PDGFRB/PTEN/BCL2L1/IGF1R/NF1/PIK3R1/AXL	3.33531479781689
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/504	60/9376	2.79047619047619	IGF1/PRKCA/PRKG1/PLA2G4D/GNAI2/PPP2CB/IGF1R/ITPR2/ITPR3	3.31603858502872
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/504	157/9376	2.01435648569407	HLA-A/CXCL8/HLA-C/AKT3/CACNA1D/CALM2/ZFP36L2/HLA-F/PPP3CA/PTEN/PPP3CB/MYC/CDKN2A/PIK3R1/ITPR2/ETS1/ITPR3	3.05484140922012
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	23/504	238/9376	1.79778578097906	ISG15/RPLP0/C1S/RPLP1/NRP1/C1R/MX1/CXCL8/PRKCA/IRF9/C3/IL1B/RPL39/OAS2/C1QA/CFD/RPL3/C1QB/MAP3K7/RPL22L1/PIK3R1/STAT1/IKBKG	2.9712509465312
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/504	30/9376	3.72063492063492	IDH2/IDH1/SUCLG2/SDHA/PDHB/SDHD	3.55719888079684
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/504	133/9376	2.09810239885428	GNG11/GNB2/PRKCA/AKT3/CACNA1D/CALM2/GNAI2/PPP3CA/PPP2CB/CREB1/CREB3L1/PPP3CB/PPP2R5E/ITPR2/ITPR3	3.03985119007703
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/504	73/9376	2.54838008262666	IGF1/PDGFRA/AKT3/FGF10/MITF/PDGFRB/PTEN/IGF1R/CDKN2A/PIK3R1	3.16532010047212
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/504	51/9376	2.91814503579209	ACTB/ATP6V0E1/KDELR2/PRKCA/ATP6V0B/SEC61G/ADCY3/KDELR1	3.27365003446862
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/504	122/9376	2.13479052823315	IGF1/PRKCA/AKT3/CACNA1D/MAP2K4/GNAI2/ADCY3/CREB1/CREB3L1/MAP3K1/PIK3R1/ITPR2/STAT1/ITPR3	3.00691401860393
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/504	75/9376	2.48042328042328	BCAT1/IDH2/IDH1/ENO1/MAT2A/PYCR1/PRPS2/RPE/SDSL/GLUL	3.06790463348009
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	25/504	275/9376	1.69119769119769	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/CACNA1D/IL1B/PSMA7/C1QA/C1QB/COX7A2L/PPP3CA/CREB1/SDHA/CREB3L1/NDUFA9/HSPA5/PPP3CB/NDUFC2/PRNP/PIK3R1/ITPR2/PSMD11/SDHD/ITPR3	2.77277231019855
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/504	76/9376	2.44778613199666	IGF1/PDGFRA/PRKCA/AKT3/CALM2/PDGFRB/PTEN/IGF1R/CDKN2A/PIK3R1	3.0203680948463
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/504	88/9376	2.32539682539683	SERPING1/C1S/C1R/C3/C1QA/TFPI/C4BPA/CFD/C1QB/SERPINA1/SERPINA5	2.97725681877203
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/504	44/9376	2.95959595959596	HLA-A/HLA-DRA/GZMB/HLA-DMA/HLA-C/IL1B/HLA-F	3.10524340698656
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/504	154/9376	1.93279736136879	BCAT1/NQO1/KYNU/MTHFD1L/NME1/DHRS3/NME7/MAT2A/GCLM/AK2/MTHFD2/UROS/GMPPB/NFS1/UGDH/AK6	2.78179582024097
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/504	90/9376	2.27372134038801	IGF1/SOD2/EHMT1/AKT3/ADCY3/CREB1/CREB3L1/IGF1R/AKT1S1/ATG101/PIK3R1	2.89381977516775
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/504	115/9376	2.10296756383713	GNG11/GNB2/PRKCA/AKT3/CACNA1D/GNAI2/ADCY3/CREB1/CREB3L1/PIK3R1/ITPR2/KCNJ2/ITPR3	2.83643515089578
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/504	142/9376	1.96512407780013	IFNGR1/AKT3/IRF9/IL1B/MITF/PPP3CA/IL1R1/CREB1/MAP3K7/PPP3CB/PIK3R1/ITPR2/STAT1/IKBKG/ITPR3	2.76199270651384
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/504	169/9376	1.87132525594064	AKT3/LAMP2/ATG12/ATG4B/VMP1/UVRAG/PTEN/PPP2CB/MTMR14/BCL2L1/SUPT20H/MAP3K7/IGF1R/AKT1S1/CTSL/ATG101/PIK3R1	2.72429869973118
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/504	157/9376	1.89586492771206	CTNNA2/ACTB/BIRC3/WWTR1/SNAI2/TEAD1/SMAD4/GDF7/TCF7L2/CSNK1E/PPP2CB/SMAD1/FZD5/MYC/TP53BP2/YWHAZ	2.69799160042854
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/504	105/9376	2.12607709750567	IGF1/LAMA2/ACTB/CACNA2D1/CACNA1D/ITGA9/SLC8A1/TPM2/ADCY3/DMD/ITGB8/ITGB1	2.7656016433673
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/504	119/9376	2.03227957849807	BIRC3/AKT3/IL1B/IL15/MAP2K4/CXCL3/DAB2IP/CREB1/CREB3L1/MAP3K7/TNFAIP3/PIK3R1/IKBKG	2.70100771384814
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/504	187/9376	1.79067990832697	BIRC3/CXCL8/HSP90AA1/IRF9/IL1B/OAS2/GBP1/GBP4/ATG12/CXCL3/BCL2L1/MAP3K7/TNFAIP3/ITPR2/HSP90AB1/STAT1/IKBKG/ITPR3	2.60302009365983
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/504	201/9376	1.75850904209113	IGF1/ZEB1/GZMB/BIRC3/HOXA10/CXCL8/PBX1/RUNX1T1/WT1/MITF/ETV1/SMAD1/BCL2L1/ETV5/IL2RB/IGF1R/BMI1/MYC/CDK9	2.59087162348363
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/504	59/9376	2.52246435297283	SMS/IDH2/IDH1/GPX3/RRM1/GCLM/ODC1/GPX2	2.79592315478894
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/504	10/9376	5.58095238095238	PAPSS1/SELENBP1/BPNT1	3.45436989757414
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/504	149/9376	1.87280281240013	PDGFRA/DGKB/CXCL8/PLPP1/PRKCA/PIP5K1B/AKT3/PLPP3/PTPN11/PDGFRB/PLA2G4D/ADCY3/FCER1G/ARF6/PIK3R1	2.55958260922801
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/504	205/9376	1.72419667053813	COL3A1/MT-CO2/COL1A1/MT-ND3/MT-CO3/MT-ND5/COL1A2/ATP5MC3/PRKCA/AKT3/COX7A2L/PTEN/SDHA/MMP2/NDUFA9/PDHB/NDUFC2/PIK3R1/SDHD	2.49870650539132
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/504	97/9376	2.10963835706104	GNG11/GNB2/RASD1/PRKCA/PRKG1/CACNA1D/CALM2/GNAI2/ADCY3/CREB1/ITPR3	2.61822448693488
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	21/504	235/9376	1.66241134751773	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/ACTB/ACSL4/COX16/PRKG1/COX11/COX7A2L/ADCY3/CREB1/SDHA/CREB3L1/ARID1A/NDUFA9/AKT1S1/NDUFC2/COA1/SDHD	2.45106585556771
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	22/504	250/9376	1.63707936507936	HLA-A/PDGFRA/ARF5/DAB2/HLA-C/PIP5K1B/WASL/PSD3/ZFYVE16/WWP1/HLA-F/ARF6/EHD2/IL2RB/IGF1R/EPS15L1/SH3KBP1/ACAP2/SNX5/STAMBP/WASHC4/VPS4A	2.43339970202178
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/504	98/9376	2.08811143505021	INPP4B/DGKB/PRKCA/PIP5K1B/CALM2/IMPA2/PTEN/MTMR14/PIK3R1/ITPR2/ITPR3	2.58077039411138
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/504	138/9376	1.88727858293076	MT-CO2/PPA1/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/ATP6V0E1/ATP6V0B/COX11/COX7A2L/SDHA/NDUFA9/NDUFC2/SDHD	2.50265337550604
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/504	39/9376	2.86202686202686	HLA-A/HLA-DRA/GZMB/HLA-DMA/HLA-C/HLA-F	2.77718432845517
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/504	99/9376	2.06701940035273	IGF1/PRKCA/IL1B/CALM2/PTGER2/PLA2G4D/ADCY3/IL1R1/PIK3R1/ITPR2/ITPR3	2.54376082437848
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/504	99/9376	2.06701940035273	PDGFRA/DGKB/PLPP1/PRKCA/PIP5K1B/AKT3/PLPP3/PDGFRB/PLA2G4D/CHPT1/PIK3R1	2.54376082437848
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/504	99/9376	2.06701940035273	IGF1/LAMA2/ACTB/CACNA2D1/CACNA1D/ITGA9/SLC8A1/TPM2/DMD/ITGB8/ITGB1	2.54376082437848
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	31/504	388/9376	1.48633611520209	MT-CO2/MT-ND3/MT-CO3/MT-ND5/MME/ATP5MC3/APOE/SLC39A14/AKT3/CACNA1D/IL1B/PSMA7/CALM2/APP/DKK1/CSNK1E/COX7A2L/PPP3CA/SDHA/FZD5/NDUFA9/PPP3CB/NDUFC2/ATG101/PIK3R1/ITPR2/PSMD11/IKBKG/HSD17B10/SDHD/ITPR3	2.33190574375544
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/504	238/9376	1.64145658263305	IGF1/PDGFRA/GNG11/GNB2/PLA2G10/PRKCA/AKT3/FGF10/CALM2/PTPN11/PDGFRB/PLA2G4D/ARF6/BCL2L1/IGF1R/NF1/PIK3R1/PLA2G12A/RGL2/ETS1/IKBKG	2.38902287274177
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/504	154/9376	1.81199752628324	ACTB/PRKCA/CACNA2D1/CACNA1D/CALM2/PLA2G4D/GNAI2/ADCY3/PPP3CA/PPP3CB/MAP2K5/MYL9/ITPR2/KCNJ2/ITPR3	2.42154557700092
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/504	51/9376	2.55337690631808	PLA2G10/PLPP1/PLPP3/PLA2G4D/CHPT1/LPCAT4/PLA2G12A	2.65110941457616
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	20/504	227/9376	1.63904622054402	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/SOD2/NQO1/AKT3/PTPN11/KEAP1/MAP2K4/COX7A2L/PTEN/SDHA/NDUFA9/NDUFC2/PIK3R1/AKR1C3/IKBKG/SDHD	2.32299633884295
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/504	76/9376	2.20300751879699	ACTB/GAST/PRKCA/CALM2/GNAI2/ADCY3/ITPR2/KCNJ2/ITPR3	2.50971151562531
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/504	89/9376	2.09024433743535	PDGFRA/PRKCA/PRKG1/GJA1/PDGFRB/GNAI2/ADCY3/MAP2K5/ITPR2/ITPR3	2.4630388385764
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/504	116/9376	1.92446633825944	ECHS1/IDH2/IDH1/ENO1/SUCLG2/SDHA/PDHB/PRPS2/GLYCTK/RPE/SDSL/SDHD	2.38783736261343
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/504	116/9376	1.92446633825944	GNG11/GNB2/PRKCA/CACNA1D/PLA2G4D/GNAI2/ADCY3/PPP3CA/PPP3CB/ITPR2/GLUL/ITPR3	2.38783736261343
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/504	31/9376	3.0005120327701	SRP14/SEC61G/HSPA5/SRP68/SPCS3	2.65902549768577
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/504	78/9376	2.14652014652015	HLA-DRA/MARCKSL1/HLA-DMA/IFNGR1/C3/IL1B/MAP3K7/ITGB1/STAT1	2.4233958552609
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/504	42/9376	2.65759637188209	ACSL4/SLC39A14/SLC40A1/GCLM/CP/PRNP	2.56601785669237
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/504	93/9376	2.00034135518007	CTNNA2/ACTB/SNAI2/SMAD4/WASL/TCF7L2/MAP3K7/IGF1R/YES1/MYL9	2.31065795677052
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/504	93/9376	2.00034135518007	HLA-DRA/HLA-DMA/IFNGR1/RBPJ/PPP3CA/IL2RB/PPP3CB/MAML2/STAT1/IKBKG	2.31065795677052
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/504	93/9376	2.00034135518007	PRKCA/CACNA1D/CALM2/MAP2K4/PLA2G4D/ADCY3/MMP2/MAP3K1/ITPR2/ITPR3	2.31065795677052
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/504	107/9376	1.9124758937843	LDHB/LDHA/AKT3/CALM2/PPP3CA/CREB1/CREB3L1/PDHB/PPP3CB/ITPR2/ITPR3	2.26249166269361
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	16/504	178/9376	1.67219546994828	APCDD1/SFRP4/PRKCA/MCC/SMAD4/ROR1/TCF7L2/DKK1/SOX17/CSNK1E/PPP3CA/MAP3K7/FZD5/PPP3CB/MYC/CCAR2	2.15798797208283
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/504	33/9376	2.81866281866282	BCAT1/IDH2/IDH1/AADAT/PDHB	2.49434271174363
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/504	69/9376	2.15688980906372	PRKCA/AKT3/ALOX5AP/MAP2K4/PLA2G4D/FCER1G/PIK3R1/ALOX5	2.29880336240523
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/504	95/9376	1.95822890559733	HLA-DRA/CCL3/ATP6V0E1/CXCL8/ATP6V0B/HLA-DMA/IL1B/IL15/CXCL3/CTSL	2.23729794463139
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/504	82/9376	2.0418118466899	UCK2/CDA/NME1/RRM1/NME7/TYMP/HPRT1/UCK1/TK2	2.25831762280201
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/504	109/9376	1.87738459298092	CCL4/CCL3/CXCL8/AKT3/IRF9/IL1B/MAP2K4/MAP3K7/PIK3R1/STAT1/IKBKG	2.19595689591205
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/504	137/9376	1.76526474336693	ACTB/GZMB/BIRC3/AKT3/PTPN13/DAB2IP/BCL2L1/CTSW/CTSL/PIK3R1/ITPR2/IKBKG/ITPR3	2.15055049973862
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/504	70/9376	2.12607709750567	HLA-A/HLA-DRA/LAMA2/ACTB/HLA-DMA/HLA-C/HLA-F/DMD	2.25385390444876
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/504	110/9376	1.86031746031746	IGF1/LDHB/LDHA/PRKCA/IFNGR1/AKT3/ENO1/IGF1R/PDHB/PIK3R1/EGLN1	2.16321194097345
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/504	181/9376	1.64447952293256	HLA-DRA/CD74/ATP6V0B/HLA-DMA/IFNGR1/AKT3/C3/IL1B/LAMP2/CALM2/FCER1G/PPP3CA/CREB1/CLEC4E/PPP3CB/STAT1	2.08671281690112
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/504	138/9376	1.75247296986427	IGF1/CALM2/ADCY3/PPP3CA/PPP2CB/ANAPC13/IGF1R/PPP3CB/PPP2R5E/ITPR2/YWHAZ/CDC27/ITPR3	2.12242136149345
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/504	138/9376	1.75247296986427	ACTB/FN1/CXCL8/PIP5K1B/AKT3/WASL/IL1B/MAP2K4/ARF6/MAP3K7/PIK3R1/ITGB1/IKBKG	2.12242136149345
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/504	170/9376	1.64145658263305	ACTB/NQO1/PRKCA/AKT3/SMAD4/TCF7L2/KEAP1/PTEN/BCL2L1/FZD5/ARID1A/IGF1R/MYC/CDKN2A/PIK3R1	2.01162202258499
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/504	60/9376	2.17037037037037	PRKCA/AKT3/PLA2G4D/PPP3CA/SH2D2A/PPP3CB/PIK3R1	2.16757604907906
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/504	142/9376	1.70310753409345	BIRC3/UBE2E3/KEAP1/WWP1/UBE2Q2/ANAPC13/MAP3K1/UBE2W/HERC2/UBA6/CDC27/UBE2A/PPIL2	2.01215359323281
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/504	216/9376	1.55026455026455	CCL3/SOD2/CXCL8/PRKCA/HSP90AA1/AKT3/IL1B/CALM2/MAP2K4/CXCL3/PPP3CA/BCL2L1/MAP3K7/HSPA5/PPP3CB/PIK3R1/HSP90AB1/IKBKG	1.95002784903408
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/504	248/9376	1.50025601638505	ACTB/BIRC3/CXCL8/EXOC4/HSP90AA1/AKT3/WASL/IL1B/TCF7L2/MAP2K4/S100A10/ARF6/MAP3K7/DYNC1LI1/MYC/PTPRC/PLEKHM2/MYL9/HSP90AB1/IKBKG	1.90291979995201
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/504	116/9376	1.76409414340449	CTNNA2/ACTB/PRKCA/PTPN11/GNAI2/MMP2/PIK3R1/MYL9/VASP/ITGB1/CLDN10	1.97360625115947
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/504	62/9376	2.10035842293907	IGF1/SOD2/AKT3/ADCY3/IGF1R/AKT1S1/PIK3R1	2.07182008995922
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/504	50/9376	2.23238095238095	SMS/CNDP2/P4HA1/PYCR1/ODC1/SMOX	2.08243959967159
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/504	63/9376	2.06701940035273	PTGDS/PLA2G10/PLA2G4D/PLA2G12A/ALOX5/LTC4S/AKR1C3	2.02529331336991
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/504	90/9376	1.86031746031746	IFNGR1/AKT3/PTPN11/PPP3CA/PTEN/PPP3CB/PIK3R1/STAT1/IKBKG	1.95459053769984
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/504	104/9376	1.78876678876679	PLA2G10/DGKB/PLPP1/LYPLA2/PLPP3/PLA2G4D/CHPT1/LPCAT4/PLA2G12A/MBOAT2	1.92782991113359
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/504	268/9376	1.45771144278607	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/SLC39A14/SNCAIP/PSMA7/CALM2/KEAP1/GNAI2/COX7A2L/SDHA/BCL2L1/NDUFA9/HSPA5/NDUFC2/ITPR2/PSMD11/SDHD/ITPR3	1.81191489774501
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/504	77/9376	1.93279736136879	AKT3/SMAD4/PTPN11/BCL2L1/MYC/CDKN2A/PIK3R1/IKBKG	1.95886581614011
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/504	105/9376	1.77173091458806	CCL4/BIRC3/CXCL8/IL1B/CXCL3/IL1R1/BCL2L1/MAP3K7/TNFAIP3/IKBKG	1.89534117188751
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/504	163/9376	1.59781867757328	CXCL8/PRKCA/AKT3/SMAD4/MAP2K4/CREB1/CREB3L1/MAP3K7/MAP3K1/MYC/PIK3R1/YWHAZ/STAT1/IKBKG	1.83507105901937
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	13/504	149/9376	1.62309577074678	MT-ND3/MT-ND5/GNG11/GNB2/PRKCA/CACNA1D/NAPEPLD/GNAI2/ADCY3/NDUFA9/NDUFC2/ITPR2/ITPR3	1.82729142943667
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/504	65/9376	2.0034188034188	PBX1/CACNA1D/ADCY3/CREB1/CREB3L1/ITPR2/ITPR3	1.93477688425631
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/504	52/9376	2.14652014652015	IGF1/PLA2G4D/ADCY3/IGF1R/ALOX5/AKR1C3	1.97593370667229
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/504	136/9376	1.64145658263305	MX1/AKT3/IRF9/IL1B/OAS2/BCL2L1/MAP3K7/TNFAIP3/IL2RB/PIK3R1/STAT1/IKBKG	1.79593607680042
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/504	122/9376	1.67733541504033	IGF1/AKT3/TBC1D1/PPP2CB/CREB1/CREB3L1/MAP3K7/IGF1R/AKT1S1/PPP2R5E/PIK3R1	1.79477119707086
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/504	94/9376	1.78115501519757	CXCL8/HSP90AA1/IL1B/CXCL3/MAPK6/MAP3K7/TNFAIP3/HSP90AB1/IKBKG	1.8141387919301
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/504	41/9376	2.26867982965544	CXCL8/TYMP/MMP2/MYC/CDKN2A	1.94033600378803
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/504	29/9376	2.56595511767926	WWTR1/TEAD1/CSNK1E/RASSF4	2.01294694276243
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/504	54/9376	2.06701940035273	HLA-A/HLA-DRA/GZMB/HLA-DMA/HLA-C/HLA-F	1.87415189430997
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/504	139/9376	1.60602946214457	HSP90AA1/AKT3/CALM2/GNAI2/ADCY3/CREB1/CREB3L1/MMP2/PIK3R1/ITPR2/HSP90AB1/ITPR3	1.71563858917433
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/504	154/9376	1.57039785611214	PRKCA/AKT3/CACNA2D1/CACNA1D/CALM2/SLC8A1/TPM2/GNAI2/ADCY3/PPP2CB/CREB1/CREB3L1/PPP2R5E	1.70104509052083
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/504	110/9376	1.69119769119769	IGF1/HSP90AA1/AKT3/GNAI2/ADCY3/ANAPC13/IGF1R/PIK3R1/HSP90AB1/CDC27	1.73797135143623
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/504	155/9376	1.56026625704045	RASD1/PBX1/CACNA1D/TCF7L2/GNAI2/ADCY3/CREB1/CREB3L1/FZD5/CDKN2A/ITPR2/ITPR3/WDR5	1.67633744096064
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/504	69/9376	1.88727858293076	PRKCA/CACNA1D/CALM2/PPP3CA/CREB1/CREB3L1/PPP3CB	1.76307110137144
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/504	156/9376	1.55026455026455	MX1/AKT3/IRF9/OAS2/IFIT1/PPP2CB/MYC/PIK3R1/YWHAZ/PSME3/STAT1/IKBKG/CLDN10	1.65180400062577
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/504	83/9376	1.7930770701855	ECI2/ACSL4/SOD2/IDH2/IDH1/PRDX1/PEX11B/PEX1	1.72968337429004
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	14/504	173/9376	1.50545921644188	HLA-DRA/ACTB/MX1/CXCL8/PRKCA/HLA-DMA/IFNGR1/AKT3/IRF9/IL1B/OAS2/PIK3R1/STAT1/IKBKG	1.5993171715173
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/504	128/9376	1.59871031746032	PAPSS1/NME1/RRM1/GMPR/NME7/ATIC/ADCY3/AK2/PRPS2/HPRT1/AK6	1.62550367784106
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	22/504	300/9376	1.3642328042328	IGF1/PDGFRA/PRKCA/AKT3/CACNA2D1/FGF10/CACNA1D/IL1B/PTPRR/PDGFRB/MAP2K4/PLA2G4D/PPP3CA/IL1R1/MAP3K7/IGF1R/MAP3K1/PPP3CB/MYC/MAP2K5/NF1/IKBKG	1.52820839499184
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	7/504	71/9376	1.83411580594679	ATP6V0E1/CXCL8/ATP6V0B/PTPN11/MAP2K4/CXCL3/IKBKG	1.68146362368423
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/504	144/9376	1.55026455026455	IGF1/AKT3/SMAD4/SMAD1/FZD5/IGF1R/TBX3/BMI1/MYC/SMARCAD1/PIK3R1/PCGF5	1.58597020127966
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	12/504	144/9376	1.55026455026455	PRKCA/AKT3/RORA/PSMA7/RBPJ/ATG101/NOP56/PIK3R1/ITPR2/PSMD11/PUM2/ITPR3	1.58597020127966
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/504	115/9376	1.61766735679779	GNG11/GNB2/PRKCA/CACNA1D/APP/PLA2G4D/GNAI2/ITPR2/ALOX5/ITPR3	1.58841788265031
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/504	32/9376	2.32539682539683	LDHB/ECHS1/LDHA/SUCLG2	1.78996541649295
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/504	32/9376	2.32539682539683	ATG12/ATG4B/PPP2CB/ATG101	1.78996541649295
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/504	72/9376	1.80864197530864	ISG15/CXCL8/ATG12/MAP3K7/AZI2/MAP3K1/IKBKG	1.64163959475833
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	9/504	101/9376	1.65770862800566	PRKCA/CALM2/MITF/TCF7L2/GNAI2/ADCY3/CREB1/CREB3L1/FZD5	1.58389871581756
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/504	59/9376	1.89184826472962	CTNNA2/AKT3/TCF7L2/PTEN/MYC/PIK3R1	1.63783093446286
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/504	46/9376	2.02208419599724	PSMB9/PSMB8/PSMA7/PSMD11/PSME3	1.65620810975784
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/504	21/9376	2.65759637188209	CHSY3/XYLT1/UST	1.81241095588163
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/504	133/9376	1.53860842582647	HLA-A/GZMB/PRKCA/HLA-C/IFNGR1/PTPN11/KLRC1/FCER1G/PPP3CA/PPP3CB/PIK3R1	1.49101710909875
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/504	89/9376	1.67219546994828	PLCL1/GNG11/GNB2/PRKCA/CACNA1D/GNAI2/ADCY3/GLUL	1.51859862303197
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/504	34/9376	2.18860877684407	RORB/RORA/CSNK1E/CREB1	1.65481176438152
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/504	77/9376	1.69119769119769	AKT3/SMAD4/BCL2L1/CDKN2A/PIK3R1/STAT1/IKBKG	1.45150874729675
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/504	184/9376	1.41545893719807	NRP1/ABLIM1/PRKCA/SEMA5A/GDF7/SLIT3/PTPN11/GNAI2/PPP3CA/ROBO1/PPP3CB/PIK3R1/MYL9/ITGB1	1.35650734390927
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	32/504	480/9376	1.24021164021164	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/PRKCA/CACNA1D/SNCAIP/GPX3/IL1B/PSMA7/CALM2/APP/DKK1/CSNK1E/COX7A2L/PPP3CA/SDHA/BCL2L1/FZD5/NDUFA9/GPX2/HSPA5/PPP3CB/NDUFC2/ATG101/PRNP/ITPR2/PSMD11/HSD17B10/SDHD/ITPR3	1.28767842777492
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/504	122/9376	1.52485037730939	AKT3/PTPN11/PPP3CA/PPP2CB/MAP3K7/PPP3CB/PTPRC/PPP2R5E/PIK3R1/IKBKG	1.39072358989317
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	11/504	140/9376	1.46167800453515	GNG11/GNB2/AKT3/SMAD4/CALM2/SLC8A1/GNAI2/ADCY3/ITPR2/ACTA2/ITPR3	1.31175092695133
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/504	65/9376	1.71721611721612	PRKCA/AKT3/CACNA1D/PIK3R1/ITPR2/ITPR3	1.3829252151523
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/504	253/9376	1.32354601919819	ACTB/CXCL8/AKT3/WASL/C3/IL1B/ATG12/IL1R1/ARF6/BCL2L1/MAP3K7/AKT1S1/PIK3R1/MYL9/ITPR2/ITGB1/IKBKG/ITPR3	1.24341935641922
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/504	66/9376	1.69119769119769	HLA-DRA/HLA-DMA/IFNGR1/RORA/IL1B/STAT1	1.34304185054314
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/504	158/9376	1.41289933694997	STAG1/SMAD4/SFN/PDS5A/PPP2CB/ANAPC13/MYC/CDKN2A/PPP2R5E/YWHAZ/CDC27/ORC2	1.24751138254306
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/504	38/9376	1.95822890559733	IGF1/PRKCA/SFN/PIK3R1	1.4106662331987
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/504	38/9376	1.95822890559733	TAP1/TAP2/PTPRC/IKBKG	1.4106662331987
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/504	67/9376	1.66595593461265	PRKCA/CALM2/PPP3CA/PPP3CB/ITPR2/ITPR3	1.30383165103252
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/504	144/9376	1.4210758377425	CXCL8/AKT3/C3/IL1B/C1QA/TCF7L2/MAP2K4/CXCL3/C1QB/MAP3K7/IKBKG	1.21362303062666
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/504	160/9376	1.3952380952381	HLA-A/HLA-DRA/NLGN1/HLA-DMA/HLA-C/VCAN/ITGA9/HLA-F/PTPRC/ITGB8/ITGB1/CLDN10	1.20181520917617
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/504	39/9376	1.90801790801791	MTHFD1L/ATIC/MAT2A/MTHFD2	1.3542946965647
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/504	98/9376	1.51862649821833	PRKCA/CACNA1D/CALM2/ADCY3/CREB1/CREB3L1/ITPR2/ITPR3	1.23007246233174
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	14/504	193/9376	1.34945308002303	CCL4/GNG11/CCL3/GNB2/XCL1/CXCL8/XCL2/AKT3/CXCL3/GNAI2/ADCY3/PIK3R1/STAT1/IKBKG	1.16913691885917
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/504	68/9376	1.64145658263305	RUNX1T1/AKT3/TCF7L2/MYC/PIK3R1/IKBKG	1.26527135251311
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/504	83/9376	1.56894243641232	AUTS2/BMI1/AEBP2/LCOR/SFMBT2/PCGF5/WDR5	1.24085074475835
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/504	26/9376	2.14652014652015	PLA2G10/PLA2G4D/PLA2G12A	1.3952521451679
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/504	99/9376	1.50328683662017	HLA-DRA/C1S/C1R/HLA-DMA/C3/C1QA/CFD/C1QB	1.19982948575868
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/504	115/9376	1.45590062111801	PRKCA/MMP16/GNAI2/ADCY3/CREB1/CREB3L1/ITPR2/WNK4/ITPR3	1.17241212656849
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/504	212/9376	1.3162623539982	IGF1/PDGFRA/ACTB/PRKCA/AKT3/FGF10/CALM2/PDGFRB/GNAI2/ADCY3/DOCK4/IGF1R/PIK3R1/VASP/ITGB1	1.11010236835124
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/504	86/9376	1.51421188630491	PRKCA/CACNA1D/KCNMB4/ADCY3/CREB1/CREB3L1/ITPR3	1.14175683427842
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/504	87/9376	1.49680715197957	MT-CO2/MT-CO3/CACNA2D1/CACNA1D/SLC8A1/TPM2/COX7A2L	1.10956595819679
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/504	42/9376	1.77173091458806	ECHS1/KYNU/AADAT/KYAT3	1.19466677231323
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	24/504	368/9376	1.21325051759834	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/ACTB/GPX3/PSMA7/NUP54/COX7A2L/PPP3CA/SDHA/BCL2L1/NUP153/NDUFA9/GPX2/HSPA5/PPP3CB/NDUFC2/ATG101/PSMD11/SDHD/ITPR3/NUP58	0.994695044651145
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/504	15/9376	2.48042328042328	AK2/NFS1	1.36760459951164
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/504	168/9376	1.32879818594104	PDGFRA/IFNGR1/AKT3/IRF9/IL15/PTPN11/PDGFRB/BCL2L1/IL2RB/MYC/PIK3R1/STAT1	1.02492370575918
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/504	73/9376	1.52902804957599	BST2/MX1/CPSF6/NUP153/CDK9/VPS4A	1.08148066345298
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/504	43/9376	1.73052787006275	PLA2G10/PLPP1/PLPP3/PLA2G12A	1.14432799813629
NA	NA	hsa04081	Hormone signaling	15/504	219/9376	1.27419004131333	IGF1/GNG11/GNB2/GAST/RAMP1/OPRK1/SLC40A1/PRKG1/SMAD4/GNAI2/ADCY3/SMAD1/IGF1R/PIK3R1/ADRA2C	0.978559566890186
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/504	59/9376	1.57654022060802	PRKG1/AKT3/GNAI2/ADCY3/PIK3R1	1.05878482429982
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/504	44/9376	1.69119769119769	ADCY3/CREB1/CREB3L1/DYNC1LI1	1.09529572308289
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/504	75/9376	1.48825396825397	BIRC3/AKT3/BCL2L1/REV3L/CDKN2A/PIK3R1	1.01181643880465
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/504	30/9376	1.86031746031746	PLA2G10/PLA2G4D/PLA2G12A	1.12485518867672
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/504	30/9376	1.86031746031746	IL1B/ATIC/IKBKG	1.12485518867672
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/504	157/9376	1.30340713780204	PBX1/SLC16A1/C1QA/MEGF10/PTPN11/PTGER2/C1QB/CREB1/ODC1/ALOX5/AXL	0.913742556470606
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	11/504	157/9376	1.30340713780204	MT-CO2/MT-CO3/CXCL8/AKT3/IL1B/COX7A2L/SDHA/NDUFA9/NDUFC2/PIK3R1/SDHD	0.913742556470606
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/504	108/9376	1.37801293356849	SUMO2/NUP54/KPNB1/NUP153/IPO5/THOC3/RNPS1/NUP58	0.941706708726471
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/504	174/9376	1.28297755883963	CANX/HSP90AA1/MAN1A1/SEC61G/ERLEC1/HERPUD1/HSPA5/SELENOS/P4HB/KRTCAP2/PDIA6/HSP90AB1	0.897998570384964
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/504	31/9376	1.80030721966206	PRPS2/GLYCTK/RPE	1.06374631504552
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/504	31/9376	1.80030721966206	ECHS1/CNDP2/SMOX	1.06374631504552
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/504	17/9376	2.18860877684407	PAPSS1/KYAT3	1.16906540680585
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/504	17/9376	2.18860877684407	LAMP2/PCDH7	1.16906540680585
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/504	93/9376	1.40023894862605	CST3/PRKCA/PRKG1/CALM2/ADCY3/ITPR2/ITPR3	0.924499728480953
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/504	110/9376	1.35295815295815	DCN/SMAD4/FBN1/GDF7/ZFYVE16/PPP2CB/SMAD1/MYC	0.8874901723618
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/504	78/9376	1.43101343101343	CTNNA2/ACTB/FN1/WASL/PIK3R1/ITGB1	0.911031668697653
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/504	47/9376	1.58324890239784	LDHB/LDHA/ACYP2/PDHB	0.955378475449065
Human Diseases	Immune disease	hsa05310	Asthma	3/504	32/9376	1.74404761904762	HLA-DRA/HLA-DMA/FCER1G	1.00484585506715
NA	NA	hsa03272	Virion - Hepatitis viruses	4/504	48/9376	1.55026455026455	LAMP2/CD63/VPS4A/CLDN10	0.910936334168042
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	15/504	232/9376	1.20279146141215	PDGFRA/ACTB/FN1/PIP5K1B/AKT3/FGF10/WASL/ITGA9/PDGFRB/ITGAE/GSN/PIK3R1/MYL9/ITGB8/ITGB1	0.745445141546638
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/504	65/9376	1.43101343101343	DGKB/PLPP1/PLPP3/GLYCTK/MBOAT2	0.831073546048281
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/504	148/9376	1.25697125697126	IGF1/AKT3/FGF10/TCF7L2/PTEN/FZD5/IGF1R/MYC/PIK3R1/HEY1	0.751020433841072
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/504	50/9376	1.48825396825397	HLA-DRA/HLA-DMA/IL15/PIGR	0.825036605949231
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/504	99/9376	1.31537598204265	IGF1/AKT3/ADCY3/MMP2/IGF1R/CDKN2A/PIK3R1	0.75185237288542
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/504	133/9376	1.25886143931257	IGF1/SOD2/AKT3/SMAD4/ATG12/CSNK1E/PTEN/IGF1R/PIK3R1	0.716600068609615
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/504	100/9376	1.30222222222222	CCL4/CCL3/XCL1/CXCL8/XCL2/CXCL3/IL2RB	0.724162721582964
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/504	20/9376	1.86031746031746	GMPPB/UGDH	0.917949454733125
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/504	168/9376	1.21806500377929	BIRC3/IFNGR1/HSP90AA1/IRF9/IL1B/PLA2G4D/TNFAIP3/VPS4A/HSP90AB1/GLUL/STAT1	0.679748250831086
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/504	308/9376	1.14759843331272	MT-CO2/MT-ND3/MT-CO3/MT-ND5/ATP5MC3/SOD2/TGM2/GPX3/PSMA7/COX7A2L/CREB1/SDHA/CREB3L1/NDUFA9/GPX2/NDUFC2/ATG101/PSMD11/SDHD	0.627756892904117
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/504	68/9376	1.36788048552754	CYP26A1/ALDH1A3/ALDH1A2/DHRS3/ALDH1A1	0.725643250204025
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	13/504	205/9376	1.17971351142083	HLA-A/HLA-C/IRF9/C3/RBPJ/HLA-F/CREB1/CREB3L1/GSN/CDKN2A/PIK3R1/YWHAZ/IKBKG	0.620068191918448
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/504	103/9376	1.26429341963323	SMG7/CPSF6/PPP2CB/CPSF3/PPP2R5E/RNPS1/NUDT21	0.642813475641193
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/504	37/9376	1.50836550836551	PRKCA/HBB/IL1B	0.738442852097373
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/504	70/9376	1.32879818594104	AKT3/PTPN11/PIK3R1/EGLN1/ETS1	0.658092662394421
NA	NA	hsa04517	IgSF CAM signaling	18/504	299/9376	1.11992355470616	NLGN1/ACTB/NRP1/PRKCA/AKT3/WASL/SLIT3/ANK3/APP/PTPN11/PMP22/ARF6/ROBO1/NTRK3/PIK3R1/MYL9/CLMP/ITGB1	0.502295236351962
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/504	56/9376	1.32879818594104	CXCL8/C3/IL1B/CXCL3	0.58817371175525
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/504	125/9376	1.19060317460317	PRKCA/AKT3/GNAI2/FCER1G/PTEN/PPP2CB/PPP2R5E/PIK3R1	0.511306054871512
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/504	91/9376	1.22658294086866	AKT3/IFITM1/PPP3CA/PPP3CB/PIK3R1/IKBKG	0.517662959963328
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/504	24/9376	1.55026455026455	HS6ST1/XYLT1	0.643302215004609
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/504	75/9376	1.24021164021164	IGF1/SFN/PTEN/BCL2L1/CDKN2A	0.497794390135797
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/504	217/9376	1.11447589788604	PRKCA/HSP90AA1/AKT3/FGF10/CACNA1D/KPNB1/GNAI2/ADCY3/CREB1/CREB3L1/MYC/PIK3R1/HSP90AB1	0.406639943027453
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/504	200/9376	1.11619047619048	ACTB/CXCL8/WASL/IL1B/PTPN11/IL1R1/ARF6/MAP3K7/ITGB1/IKBKG/MYO10/CLDN10	0.395866696416694
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/504	254/9376	1.09861267341582	PDGFRA/EDNRA/PRKCA/FGF10/CACNA1D/CALM2/SLC8A1/PDGFRB/ADCY3/PPP3CA/ORAI3/PPP3CB/NTRK3/ITPR2/ITPR3	0.379747302005584
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/504	43/9376	1.29789590254707	ECI2/ECHS1/ACSL4	0.466636025515909
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/504	78/9376	1.19251119251119	INPP4B/PIP5K1B/IMPA2/PTEN/MTMR14	0.406910273176572
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/504	44/9376	1.26839826839827	MNAT1/GTF2F2/TAF12	0.425313161781665
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/504	62/9376	1.20020481310804	RBPJ/NUMB/MAML2/HEY1	0.376957494264334
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/504	28/9376	1.32879818594104	ECHS1/HACD3	0.415278279346951
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/504	100/9376	1.11619047619048	HLA-DRA/MME/HLA-DMA/IL1B/IL1R1/CD7	0.27840709674303
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/504	46/9376	1.21325051759834	CP/UROS/HMOX2	0.345555912164194
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/504	120/9376	1.08518518518519	AKT3/CALM2/PTPN11/MAP3K1/NTRK3/MAP2K5/PIK3R1	0.22383766242644
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/504	102/9376	1.09430438842204	PLA2G10/PRKCA/ADCY3/ITPR2/PLA2G12A/ITPR3	0.228238331018614
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/504	158/9376	1.05967450271248	IGF1/PRKCA/AKT3/CASTOR1/PTEN/FZD5/IGF1R/AKT1S1/PIK3R1	0.180297265506224
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/504	48/9376	1.16269841269841	ECHS1/BCAT1/HSD17B10	0.269339348804493
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/504	48/9376	1.16269841269841	AKT3/CACNA1D/PIK3R1	0.269339348804493
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/504	12/9376	1.55026455026455	NQO1	0.454591797805256
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/504	67/9376	1.11063728974177	LDHB/LDHA/ENO1/PDHB	0.216609527225965
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/504	86/9376	1.08157991878922	PRKCA/AKT3/MAP2K4/MYC/PIK3R1	0.181140172559606
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/504	49/9376	1.13896987366375	GALNT13/GALNT17/GXYLT2	0.232454444463981
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/504	49/9376	1.13896987366375	GNAI2/CREB1/CREB3L1	0.232454444463981
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/504	31/9376	1.20020481310804	GLYCTK/GLUL	0.266106723725399
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/504	87/9376	1.06914796569969	AKT3/SMAD4/TCF7L2/MYC/PIK3R1	0.154434630244797
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/504	50/9376	1.11619047619048	CXCL8/HBB/IL1B	0.196335109088048
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/504	32/9376	1.16269841269841	BIRC3/BCL2L1	0.219726293641351
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/504	70/9376	1.06303854875283	ACSL4/AKT3/PTPN11/IKBKG	0.12617224837631
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/504	109/9376	1.02402795980778	AKT3/PTPN11/PTEN/CREB1/CREB3L1/PIK3R1	0.0601382386432347
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/504	91/9376	1.02215245072388	GNG11/GNB2/PRKCA/GNAI2/ADCY3	0.0506106204121191
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/504	73/9376	1.01935203305066	PRKCA/AKT3/CDKN2A/PIK3R1	0.0395609449434094
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/504	150/9376	0.992169312169312	CTNNA2/AKT3/FGF10/SMAD4/TCF7L2/FZD5/MYC/PIK3R1	-0.0230424660063921
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/504	36/9376	1.03350970017637	RPE/UGDH	0.0480107504230239
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/504	36/9376	1.03350970017637	GALNT13/GALNT17	0.0480107504230239
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/504	36/9376	1.03350970017637	RNASEH1/POLE4	0.0480107504230239
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/504	56/9376	0.996598639455782	MAN1A1/KRTCAP2/DPM2	-0.00608455563884738
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/504	56/9376	0.996598639455782	CSNK1G2/CSNK1E/CSNK1G3	-0.00608455563884738
NA	NA	hsa04519	Cadherin signaling	21/504	404/9376	0.966996699669967	LHFPL3/PDGFRA/VIM/CTNNA2/ACTB/LHFPL6/WWTR1/CDH11/TEAD1/RERE/TCF7L2/GJA1/PDGFRB/PCDH7/FZD5/IGF1R/KRT81/VASP/PCDH18/YWHAZ/IKBKG	-0.16161942653478
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/504	57/9376	0.979114452798663	ECHS1/ACSL4/HACD3	-0.037695435929855
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/504	37/9376	1.00557700557701	GMPPB/UGDH	0.00810106082469692
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/504	37/9376	1.00557700557701	TCF7L2/MYC	0.00810106082469692
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/504	117/9376	0.954008954008954	ACTB/ACTR6/RSF1/ARID1A/BCL7A/INO80E	-0.119309304949728
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/504	17/9376	1.09430438842204	GLUL	0.0927538146798046
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/504	38/9376	0.979114452798663	GMPPB/UGDH	-0.0307468664603029
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/504	18/9376	1.03350970017637	ACSL4	0.0339160614949855
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/504	18/9376	1.03350970017637	PRDX1	0.0339160614949855
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/504	122/9376	0.914910226385636	ACTB/PRKCA/AKT3/MYC/PIK3R1/STAT1	-0.225466838817584
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/504	19/9376	0.979114452798663	HPSE2	-0.0217192329741716
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/504	19/9376	0.979114452798663	PDHB	-0.0217192329741716
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/504	143/9376	0.910644910644911	HLA-DRA/C1S/C1R/HLA-DMA/C3/C1QA/C1QB	-0.256629178811254
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/504	41/9376	0.907471931862176	GLYCTK/SDSL	-0.141513672537485
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/504	41/9376	0.907471931862176	UIMC1/RAD51B	-0.141513672537485
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/504	63/9376	0.885865457294029	ECHS1/EHMT1/AADAT	-0.216637041548186
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/504	63/9376	0.885865457294029	MNAT1/POLE4/ERCC6	-0.216637041548186
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/504	226/9376	0.905464250596994	EDNRA/AKT3/CACNA1D/CALM2/PTGER2/GNAI2/ADCY3/CREB1/CREB3L1/PIK3R1/MYL9	-0.342870312830144
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/504	21/9376	0.885865457294029	BCAT1	-0.124794370423222
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/504	44/9376	0.845598845598846	MAN1A1/KRTCAP2	-0.24466939951956
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/504	170/9376	0.875443510737628	ACTB/CACNA1D/PPP2CB/MAP3K1/MYL9/VASP/ITGB1/CLDN10	-0.390611903657696
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/504	22/9376	0.845598845598846	CNDP2	-0.172803820712501
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/504	45/9376	0.826807760141093	TAP1/TAP2	-0.277562461910246
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/504	23/9376	0.808833678398896	GLUL	-0.218771111990208
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/504	23/9376	0.808833678398896	IDI1	-0.218771111990208
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/504	23/9376	0.808833678398896	MME	-0.218771111990208
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/504	47/9376	0.791624451198919	CACNA1D/PIK3R1	-0.34132514148933
NA	NA	hsa04382	Cornified envelope formation	10/504	217/9376	0.857289152220028	COL4A1/COL4A2/COL4A5/S100A10/S100A6/PPP2CB/PPP2R5E/KRT81/PCSK6/CLDN10	-0.506935801179911
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/504	71/9376	0.786049631120054	AKT3/PIK3R1/STAT1	-0.431294743464436
Genetic Information Processing	Translation	hsa03010	Ribosome	10/504	222/9376	0.837980837980838	RPLP0/RPLP1/RPL39/RPL3/MRPS5/MRPL49/MRPL42/MRPL47/RPL22L1/MRPS25	-0.582274209766043
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/504	27/9376	0.689006466784244	ECHS1	-0.385692150632364
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/504	27/9376	0.689006466784244	HACD3	-0.385692150632364
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/504	53/9376	0.702006588799042	PRKCA/SLC8A1	-0.518509710608238
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/504	28/9376	0.664399092970521	ST3GAL4	-0.423870243747233
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/504	28/9376	0.664399092970521	AKR1C3	-0.423870243747233
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/504	28/9376	0.664399092970521	ATP6V0E1	-0.423870243747233
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/504	250/9376	0.818539682539682	ATP6V0E1/ATP6V0B/LAMP2/MITF/CD63/LITAF/AP1S2/CTSW/AKT1S1/CTSL/OSBPL1A	-0.693109064020157
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/504	78/9376	0.715506715506716	DCPS/CNOT2/ENO1	-0.60133251786559
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/504	29/9376	0.641488779419814	CALM2	-0.460845944603074
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/504	55/9376	0.676479076479076	PLPP1/PLPP3	-0.573512125286787
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/504	30/9376	0.62010582010582	DPM2	-0.496707272736704
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/504	298/9376	0.811547885373389	CCL4/CCL3/XCL1/CXCL8/XCL2/IFNGR1/GDF7/IL1B/GDF11/IL15/CXCL3/IL1R1/IL2RB	-0.787960047546423
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/504	31/9376	0.600102406554019	UGDH	-0.531532867594723
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/504	105/9376	0.708692365835223	MITF/TOMM70/CCZ1/BCL2L1	-0.715440242551859
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/504	194/9376	0.767141220749468	ACTB/TPM2/KIF26B/DYNC1LI1/KIF13A/MYL9/ACTA2/MYO10	-0.781114998535465
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/504	83/9376	0.672403901319564	CCL4/IL1B/IKBKG	-0.714479773368419
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/504	323/9376	0.806329549363605	ZEB1/PDGFRA/VIM/TIMP3/ZFPM2/PRKCA/ZEB2/MMP16/PDGFRB/PTEN/BMI1/MYC/CDKN2A/PIK3R1	-0.844225573761631
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/504	33/9376	0.563732563732564	VAMP3	-0.598351980838791
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/504	35/9376	0.531519274376417	GMPPB	-0.661788481128095
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/504	63/9376	0.590576971529352	TCF7L2/FZD5	-0.777119630277711
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/504	37/9376	0.502788502788503	GLUL	-0.722240730447979
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/504	38/9376	0.489557226399332	NNMT	-0.751453416289805
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/504	44/9376	0.422799422799423	POLE4	-0.914651960820784
NA	NA	hsa04082	Neuroactive ligand signaling	7/504	199/9376	0.654383026242323	GNG11/GNB2/OPRK1/PRKCA/GNAI2/ADCY3/ADRA2C	-1.17452259336873
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/504	76/9376	0.489557226399332	FABP5/ACSL4	-1.06488453892157
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/504	79/9376	0.47096644564999	ATP6V0E1/ATP6V0B	-1.12542222750669
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/504	183/9376	0.609940150923758	UTP15/RIOK2/NOP56/GNL3/WDR75/AK6	-1.27004264286578
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/504	52/9376	0.357753357753358	APOE	-1.10685956305604
Human Diseases	Substance dependence	hsa05034	Alcoholism	6/504	191/9376	0.584392919471453	GNG11/GNB2/CALM2/GNAI2/CREB1/CREB3L1	-1.38308917102057
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/504	54/9376	0.344503233392122	REV3L	-1.1513384915458
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/504	243/9376	0.612450192697106	DHX15/PLRG1/PRPF38A/RBMX/THOC3/SF3B3/SRSF9/PRPF18	-1.45886153324612
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/504	195/9376	0.572405372405372	ACTB/PRKCA/AKT3/C3/MAP3K7/PIK3R1	-1.43811856201933
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/504	66/9376	0.281866281866282	AKR1C3	-1.39538029426647
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/504	138/9376	0.404416839199448	AKT3/CALM2/PIK3R1	-1.67989877863239
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/504	86/9376	0.216315983757844	ITPR3	-1.74009315087802
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/504	90/9376	0.206701940035273	ADCY3	-1.80232641217177
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/504	370/9376	0.402230802230802	CALCRL/OPRK1/EDNRA/GZMA/C3/PTGER2/PGRMC1/ADRA2C	-2.79613775257469
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/504	449/9376	0.165729840562803	PRKG1/CALM2/SLC8A1/ADCY3	-4.31784703423256