category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/7	60/9376	44.647619047619	PLCB1/BRAF	9.27063499222027
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/7	67/9376	39.9829424307036	PLCB1/BRAF	8.75283096580155
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/7	101/9376	26.5233380480905	PLCB1/COL3A1	7.04902805537723
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/7	103/9376	26.0083217753121	PLCB1/COL3A1	6.97559198269867
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/7	106/9376	25.2722371967655	ZEB1/BRAF	6.86927513999666
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/7	115/9376	23.2944099378882	PLCB1/BRAF	6.5751247822885
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/7	115/9376	23.2944099378882	PLCB1/BRAF	6.5751247822885
Organismal Systems	Immune system	hsa04611	Platelet activation	2/7	126/9376	21.2607709750567	PLCB1/COL3A1	6.25832931772802
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/7	130/9376	20.6065934065934	PLCB1/COL3A1	6.15297163553252
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/7	134/9376	19.9914712153518	PLCB1/BRAF	6.052238939439
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/7	155/9376	17.2829493087558	PLCB1/BRAF	5.58724798630041
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/7	193/9376	13.880088823094	PLCB1/BRAF	4.94189210202739
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	2/7	205/9376	13.0675958188153	PLCB1/COL3A1	4.77504400701743
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/7	212/9376	12.6361185983827	PLCB1/BRAF	4.6840504925427
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/7	37/9376	36.2007722007722	PLCB1	5.86395871195378
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/7	37/9376	36.2007722007722	BRAF	5.86395871195378
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/7	41/9376	32.6689895470383	BRAF	5.55465400984094
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/7	388/9376	6.90427098674521	PLCB1/BRAF	3.24667376462758
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/7	48/9376	27.9047619047619	PLCB1	5.10791359065074
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/7	53/9376	25.2722371967655	PLCB1	4.84348477553466
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/7	59/9376	22.7021791767554	BRAF	4.57066447461216
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/7	63/9376	21.2607709750567	PTGDS	4.41031367943591
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/7	480/9376	5.58095238095238	PLCB1/BRAF	2.81622304259277
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/7	65/9376	20.6065934065934	PLCB1	4.33559489690771
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/7	65/9376	20.6065934065934	PLCB1	4.33559489690771
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/7	68/9376	19.6974789915966	BRAF	4.22958114828355
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/7	69/9376	19.4120082815735	PLCB1	4.19574309681397
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/7	70/9376	19.134693877551	BRAF	4.16261038629487
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/7	73/9376	18.3483365949119	BRAF	4.06720252147318
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/7	73/9376	18.3483365949119	BRAF	4.06720252147318
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/7	75/9376	17.8590476190476	PLCB1	4.00670054941334
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/7	76/9376	17.6240601503759	PLCB1	3.97731934187549
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/7	76/9376	17.6240601503759	BRAF	3.97731934187549
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/7	77/9376	17.3951762523191	BRAF	3.94849295316817
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/7	77/9376	17.3951762523191	BRAF	3.94849295316817
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/7	78/9376	17.1721611721612	PLCB1	3.92020366199759
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/7	80/9376	16.7428571428571	BRAF	3.86516936950502
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/7	86/9376	15.5747508305648	BRAF	3.71133832329232
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/7	86/9376	15.5747508305648	PLCB1	3.71133832329232
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/7	86/9376	15.5747508305648	PLCB1	3.71133832329232
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/7	87/9376	15.3957307060755	BRAF	3.68720171845472
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/7	89/9376	15.0497592295345	PLCB1	3.64010742979989
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/7	93/9376	14.4024577572965	PLCB1	3.55033868694596
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/7	93/9376	14.4024577572965	PLCB1	3.55033868694596
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/7	97/9376	13.8085419734904	PLCB1	3.46595575431119
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/7	98/9376	13.667638483965	PLCB1	3.44563724516159
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/7	98/9376	13.667638483965	PLCB1	3.44563724516159
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/7	99/9376	13.5295815295815	BRAF	3.42561399439072
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/7	99/9376	13.5295815295815	PLCB1	3.42561399439072
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/7	101/9376	13.2616690240453	PLCB1	3.3864241735697
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/7	102/9376	13.1316526610644	PLCB1	3.3672436799336
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/7	103/9376	13.004160887656	COL3A1	3.34833057568948
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/7	103/9376	13.004160887656	PLCB1	3.34833057568948
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/7	107/9376	12.5180240320427	PLCB1	3.27522746233593
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/7	110/9376	12.1766233766234	BRAF	3.22291498675069
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/7	115/9376	11.6472049689441	PLCB1	3.14010110374964
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/7	116/9376	11.5467980295567	PLCB1	3.12415209962532
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/7	120/9376	11.1619047619048	BRAF	3.06226033567528
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/7	122/9376	10.9789227166276	PLCB1	3.03240263720604
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/7	122/9376	10.9789227166276	PLCB1	3.03240263720604
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/7	125/9376	10.7154285714286	PLCB1	2.9888950646123
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/7	133/9376	10.0708915145005	BRAF	2.87976703259153
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/7	133/9376	10.0708915145005	BRAF	2.87976703259153
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/7	133/9376	10.0708915145005	PLCB1	2.87976703259153
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/7	138/9376	9.70600414078675	BRAF	2.81616095170918
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/7	139/9376	9.63617677286742	PLCB1	2.8038287868474
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/7	140/9376	9.56734693877551	PLCB1	2.79162094867456
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/7	144/9376	9.3015873015873	PLCB1	2.74399001239375
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/7	148/9376	9.05019305019305	BRAF	2.69818298174373
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/7	149/9376	8.98945349952061	PLCB1	2.68700197737182
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/7	149/9376	8.98945349952061	PLCB1	2.68700197737182
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/7	150/9376	8.92952380952381	BRAF	2.6759257000129
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/7	154/9376	8.69758812615956	PLCB1	2.63263414559512
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/7	154/9376	8.69758812615956	PLCB1	2.63263414559512
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/7	156/9376	8.58608058608059	BRAF	2.61157395777984
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/7	158/9376	8.47739602169982	BRAF	2.59088784114711
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/7	163/9376	8.21735319894829	BRAF	2.5407343808743
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/7	166/9376	8.06884681583477	PLCB1	2.51165993595973
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/7	170/9376	7.87899159663866	BRAF	2.47401195015242
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/7	178/9376	7.52487961476726	PLCB1	2.40228118882247
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/7	187/9376	7.16271963330787	PLCB1	2.3267360921066
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/7	191/9376	7.01271503365744	BRAF	2.29475203378969
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/7	195/9376	6.86886446886447	PLCB1	2.26367685842752
NA	NA	hsa04082	Neuroactive ligand signaling	1/7	199/9376	6.73079684134961	PLCB1	2.23346537427338
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/7	201/9376	6.6638237384506	ZEB1	2.21867025197296
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/7	203/9376	6.5981703026038	BRAF	2.20407549958102
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	1/7	204/9376	6.56582633053221	BRAF	2.19685174984767
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	1/7	216/9376	6.2010582010582	PLCB1	2.1137756522795
NA	NA	hsa04081	Hormone signaling	1/7	219/9376	6.11611219830398	PLCB1	2.09398491742935
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/7	226/9376	5.92667509481669	BRAF	2.04920606965921
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	1/7	227/9376	5.90056639395846	PLCB1	2.04296266978105
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/7	227/9376	5.90056639395846	BRAF	2.04296266978105
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/7	232/9376	5.77339901477833	BRAF	2.01229506267908
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/7	233/9376	5.74862047823421	COL3A1	2.00626871239259
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/7	238/9376	5.62785114045618	RASAL2	1.9766524786679
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/7	253/9376	5.29418407679277	PLCB1	1.89260559260522
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/7	254/9376	5.27334083239595	PLCB1	1.88724114217694
NA	NA	hsa04517	IgSF CAM signaling	1/7	299/9376	4.47969421882465	TRIO	1.67145060505879
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	1/7	300/9376	4.4647619047619	BRAF	1.66715054274408
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/7	308/9376	4.34879406307978	PLCB1	1.63341328051133
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/7	323/9376	4.1468376824414	ZEB1	1.5731400284236