ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0030695 GTPase regulator activity 35/460 489/18639 0.0715746421267894 2.90017337956788 1.90504834297808e-08 8.20227303163084e-06 GO:0060589 nucleoside-triphosphatase regulator activity 35/460 490/18639 0.0714285714285714 2.89425465838509 2.00544572900509e-08 8.20227303163084e-06 GO:0005096 GTPase activator activity 21/460 271/18639 0.0774907749077491 3.13989250762073 4.08792092082285e-06 0.0011146397710777 GO:0031267 small GTPase binding 21/460 283/18639 0.0742049469964664 3.00675218927639 8.00594936724041e-06 0.00163721664560066 GO:0051020 GTPase binding 21/460 315/18639 0.0666666666666667 2.70130434782609 3.97751956955311e-05 0.00650722201578889 GO:0050786 RAGE receptor binding 4/460 11/18639 0.363636363636364 14.7343873517787 0.000105282786008799 0.0143535531591997 GO:0017124 SH3 domain binding 10/460 115/18639 0.0869565217391304 3.5234404536862 0.000562442698461163 0.0633900233310249 GO:0005085 guanyl-nucleotide exchange factor activity 15/460 230/18639 0.0652173913043478 2.64258034026465 0.000619951328420782 0.0633900233310249 GO:0051015 actin filament binding 14/460 209/18639 0.0669856459330144 2.71422924901186 0.000717627060805667 0.0648954668716316 GO:0048306 calcium-dependent protein binding 8/460 80/18639 0.1 4.05195652173913 0.000793343115790118 0.0648954668716316 GO:0015173 aromatic amino acid transmembrane transporter activity 3/460 11/18639 0.272727272727273 11.050790513834 0.00212571327480497 0.0662375664230802 GO:0019864 IgG binding 3/460 11/18639 0.272727272727273 11.050790513834 0.00212571327480497 0.0662375664230802 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/460 23/18639 0.173913043478261 7.0468809073724 0.00223384728819746 0.0662375664230802 GO:0140313 molecular sequestering activity 6/460 55/18639 0.109090909090909 4.4203162055336 0.00227985743503549 0.0662375664230802 GO:0140297 DNA-binding transcription factor binding 23/460 488/18639 0.0471311475409836 1.90973360655738 0.00245198191496186 0.0662375664230802 GO:0003725 double-stranded RNA binding 7/460 75/18639 0.0933333333333333 3.78182608695652 0.00249278687854104 0.0662375664230802 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/460 24/18639 0.166666666666667 6.75326086956522 0.00262895984746978 0.0662375664230802 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/460 24/18639 0.166666666666667 6.75326086956522 0.00262895984746978 0.0662375664230802 GO:0035259 nuclear glucocorticoid receptor binding 3/460 12/18639 0.25 10.1298913043478 0.00278266772351865 0.0662375664230802 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 14/460 243/18639 0.0576131687242798 2.33446054750403 0.00296868349236652 0.0662375664230802 GO:0004676 3-phosphoinositide-dependent protein kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0004711 ribosomal protein S6 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0035175 histone H3S10 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0035979 histone H2AXS139 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0044022 histone H3S28 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0044023 histone H4S1 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0044024 histone H2AS1 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0044025 histone H2BS14 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0072354 histone H3T3 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0072371 histone H2AS121 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0072518 Rho-dependent protein serine/threonine kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0140823 histone H2BS36 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0140855 histone H3S57 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0140995 histone H2A kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0140997 histone H4 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0140998 histone H2B kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:1990244 histone H2AT120 kinase activity 14/460 245/18639 0.0571428571428571 2.31540372670807 0.00319576936622317 0.0662375664230802 GO:0004677 DNA-dependent protein kinase activity 14/460 246/18639 0.0569105691056911 2.3059915164369 0.00331453416248819 0.0662375664230802 GO:0140857 histone H3T45 kinase activity 14/460 246/18639 0.0569105691056911 2.3059915164369 0.00331453416248819 0.0662375664230802 GO:0035402 histone H3T11 kinase activity 14/460 247/18639 0.0566801619433198 2.29665551839465 0.00343688479141232 0.0662375664230802 GO:0035403 histone H3T6 kinase activity 14/460 247/18639 0.0566801619433198 2.29665551839465 0.00343688479141232 0.0662375664230802 GO:0003779 actin binding 21/460 443/18639 0.0474040632054176 1.92079203062126 0.00347496383432562 0.0662375664230802 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/460 26/18639 0.153846153846154 6.23377926421405 0.00355775619079857 0.0662375664230802 GO:0004679 AMP-activated protein kinase activity 14/460 248/18639 0.0564516129032258 2.28739481065919 0.00356290088339307 0.0662375664230802 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/460 89/18639 0.0786516853932584 3.18693209574988 0.00645549948178712 0.114795621219606 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/460 89/18639 0.0786516853932584 3.18693209574988 0.00645549948178712 0.114795621219606 GO:0140793 histone H2AXY142 phosphatase activity 7/460 90/18639 0.0777777777777778 3.15152173913043 0.00685540891834975 0.11931328713213 GO:0030515 snoRNA binding 4/460 32/18639 0.125 5.06494565217391 0.00761901478703574 0.125884931895231 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/460 17/18639 0.176470588235294 7.15051150895141 0.0078485715484802 0.125884931895231 GO:0008484 sulfuric ester hydrolase activity 3/460 17/18639 0.176470588235294 7.15051150895141 0.0078485715484802 0.125884931895231 GO:0019198 transmembrane receptor protein phosphatase activity 3/460 17/18639 0.176470588235294 7.15051150895141 0.0078485715484802 0.125884931895231 GO:0019239 deaminase activity 4/460 33/18639 0.121212121212121 4.91146245059289 0.00850417695774632 0.133110442087411 GO:0106310 protein serine kinase activity 17/460 361/18639 0.0470914127423823 1.90812356979405 0.00862451519637257 0.133110442087411 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/460 34/18639 0.117647058823529 4.76700767263427 0.00945399221832016 0.143210474714554 GO:0004725 protein tyrosine phosphatase activity 7/460 98/18639 0.0714285714285714 2.89425465838509 0.0107461670333871 0.159824811514739 GO:0035091 phosphatidylinositol binding 14/460 284/18639 0.0492957746478873 1.9974433557869 0.0112826336416196 0.164807041407943 GO:0004674 protein serine/threonine kinase activity 19/460 433/18639 0.0438799076212471 1.77799477859223 0.0115811470100437 0.166199618495014 GO:0042288 MHC class I protein binding 3/460 20/18639 0.15 6.0779347826087 0.0124582395708348 0.175704137395567 GO:0003714 transcription corepressor activity 11/460 204/18639 0.053921568627451 2.18487851662404 0.0127141954581402 0.176274777707774 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 16/460 349/18639 0.0458452722063037 1.85763049707238 0.0134491643771775 0.183356941008853 GO:0061980 regulatory RNA binding 5/460 58/18639 0.0862068965517241 3.49306596701649 0.0140502988218085 0.186578320931773 GO:0031490 chromatin DNA binding 8/460 128/18639 0.0625 2.53247282608696 0.0141416331268581 0.186578320931773 GO:0004879 nuclear receptor activity 5/460 59/18639 0.0847457627118644 3.43386145910096 0.0150491332052842 0.195231340998608 GO:0140375 immune receptor activity 9/460 156/18639 0.0576923076923077 2.33766722408027 0.0155073811841959 0.195231340998608 GO:0004857 enzyme inhibitor activity 18/460 416/18639 0.0432692307692308 1.7532504180602 0.0156624513164115 0.195231340998608 GO:0098531 ligand-modulated transcription factor activity 5/460 60/18639 0.0833333333333333 3.37663043478261 0.0160943710160577 0.195231340998608 GO:0031683 G-protein beta/gamma-subunit complex binding 3/460 22/18639 0.136363636363636 5.525395256917 0.0162295002297131 0.195231340998608 GO:0061133 endopeptidase activator activity 3/460 22/18639 0.136363636363636 5.525395256917 0.0162295002297131 0.195231340998608 GO:1901981 phosphatidylinositol phosphate binding 10/460 185/18639 0.0540540540540541 2.19024676850764 0.0168025539812031 0.199195495023538 GO:0004860 protein kinase inhibitor activity 6/460 84/18639 0.0714285714285714 2.89425465838509 0.0176477726976721 0.206226829524225 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/460 41/18639 0.0975609756097561 3.95312831389183 0.0180467890837117 0.207919344654594 GO:0042578 phosphoric ester hydrolase activity 16/460 363/18639 0.0440771349862259 1.78598634567014 0.0187806454826846 0.21183193765967 GO:0019894 kinesin binding 4/460 42/18639 0.0952380952380952 3.85900621118012 0.0195683514916844 0.21183193765967 GO:0035198 miRNA binding 4/460 42/18639 0.0952380952380952 3.85900621118012 0.0195683514916844 0.21183193765967 GO:0048487 beta-tubulin binding 4/460 42/18639 0.0952380952380952 3.85900621118012 0.0195683514916844 0.21183193765967 GO:0140789 histone phosphatase activity 8/460 136/18639 0.0588235294117647 2.38350383631714 0.0196812069219253 0.21183193765967 GO:0016922 nuclear receptor binding 8/460 137/18639 0.0583941605839416 2.36610599809584 0.0204686100004367 0.217445752991652 GO:0005200 structural constituent of cytoskeleton 7/460 112/18639 0.0625 2.53247282608696 0.0210567876462747 0.220826311469906 GO:0019210 kinase inhibitor activity 6/460 90/18639 0.0666666666666667 2.70130434782609 0.0239339830940194 0.228160260725985 GO:0001221 transcription coregulator binding 7/460 115/18639 0.0608695652173913 2.46640831758034 0.0239377655336483 0.228160260725985 GO:0005031 tumor necrosis factor receptor activity 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0030957 Tat protein binding 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0031434 mitogen-activated protein kinase kinase binding 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0043422 protein kinase B binding 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/460 10/18639 0.2 8.10391304347826 0.0239875090738811 0.228160260725985 GO:0042605 peptide antigen binding 4/460 45/18639 0.0888888888888889 3.60173913043478 0.0245976604809945 0.231274554867282 GO:0019865 immunoglobulin binding 3/460 26/18639 0.115384615384615 4.67533444816053 0.02548887083596 0.236930640270628 GO:1990841 promoter-specific chromatin binding 5/460 68/18639 0.0735294117647059 2.97937979539642 0.0262193678143057 0.240982504180922 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/460 11/18639 0.181818181818182 7.36719367588933 0.0288456859181203 0.253717968613144 GO:0034511 U3 snoRNA binding 2/460 11/18639 0.181818181818182 7.36719367588933 0.0288456859181203 0.253717968613144 GO:0070990 snRNP binding 2/460 11/18639 0.181818181818182 7.36719367588933 0.0288456859181203 0.253717968613144 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/460 11/18639 0.181818181818182 7.36719367588933 0.0288456859181203 0.253717968613144 GO:0044389 ubiquitin-like protein ligase binding 14/460 322/18639 0.0434782608695652 1.7617202268431 0.0296313205350178 0.256263383599701 GO:0004721 phosphoprotein phosphatase activity 9/460 175/18639 0.0514285714285714 2.08386335403727 0.0299573151518879 0.256263383599701 GO:0140693 molecular condensate scaffold activity 4/460 48/18639 0.0833333333333333 3.37663043478261 0.0303394879907204 0.256263383599701 GO:0141003 histone H2AX kinase activity 15/460 354/18639 0.0423728813559322 1.71693072955048 0.0303882007447078 0.256263383599701 GO:0051019 mitogen-activated protein kinase binding 3/460 28/18639 0.107142857142857 4.34138198757764 0.0309800464847219 0.258588551270434 GO:0140996 histone H3 kinase activity 15/460 357/18639 0.0420168067226891 1.70250274022653 0.0323808430600206 0.265149579134414 GO:0016763 pentosyltransferase activity 4/460 49/18639 0.0816326530612245 3.30771960958296 0.0324143739773123 0.265149579134414 GO:0035250 UDP-galactosyltransferase activity 3/460 29/18639 0.103448275862069 4.19167916041979 0.0339393450606575 0.266778845214995 GO:0004126 cytidine deaminase activity 2/460 12/18639 0.166666666666667 6.75326086956522 0.0340582895570406 0.266778845214995 GO:0004875 complement receptor activity 2/460 12/18639 0.166666666666667 6.75326086956522 0.0340582895570406 0.266778845214995 GO:0035197 siRNA binding 2/460 12/18639 0.166666666666667 6.75326086956522 0.0340582895570406 0.266778845214995 GO:0035173 histone kinase activity 15/460 360/18639 0.0416666666666667 1.6883152173913 0.0344674708335813 0.266778845214995 GO:0032813 tumor necrosis factor receptor superfamily binding 4/460 50/18639 0.08 3.2415652173913 0.0345703638053661 0.266778845214995 GO:0070566 adenylyltransferase activity 3/460 30/18639 0.1 4.05195652173913 0.0370397973551624 0.282395904442516 GO:0043130 ubiquitin binding 6/460 100/18639 0.06 2.43117391304348 0.0374482720784117 0.282395904442516 GO:0031625 ubiquitin protein ligase binding 13/460 302/18639 0.043046357615894 1.74421969478837 0.0376951887179216 0.282395904442516 GO:0003712 transcription coregulator activity 19/460 495/18639 0.0383838383838384 1.55529644268775 0.0390800665503398 0.282395904442516 GO:0016791 phosphatase activity 12/460 273/18639 0.043956043956044 1.78107978977544 0.0391496713504848 0.282395904442516 GO:0005035 death receptor activity 2/460 13/18639 0.153846153846154 6.23377926421405 0.0396049473713889 0.282395904442516 GO:0035325 Toll-like receptor binding 2/460 13/18639 0.153846153846154 6.23377926421405 0.0396049473713889 0.282395904442516 GO:0070700 BMP receptor binding 2/460 13/18639 0.153846153846154 6.23377926421405 0.0396049473713889 0.282395904442516 GO:0017022 myosin binding 5/460 76/18639 0.0657894736842105 2.66576086956522 0.0397011357101337 0.282395904442516 GO:0005543 phospholipid binding 19/460 497/18639 0.0382293762575453 1.5490377044878 0.040423891886437 0.285058134164703 GO:0008378 galactosyltransferase activity 3/460 32/18639 0.09375 3.79870923913043 0.0436588671074116 0.300745935863003 GO:0140463 chromatin-protein adaptor activity 4/460 54/18639 0.0740740740740741 3.00144927536232 0.0440090825920925 0.300745935863003 GO:0008191 metalloendopeptidase inhibitor activity 2/460 14/18639 0.142857142857143 5.78850931677019 0.0454660726318851 0.300745935863003 GO:0019763 immunoglobulin receptor activity 2/460 14/18639 0.142857142857143 5.78850931677019 0.0454660726318851 0.300745935863003 GO:0044548 S100 protein binding 2/460 14/18639 0.142857142857143 5.78850931677019 0.0454660726318851 0.300745935863003 GO:0046030 inositol trisphosphate phosphatase activity 2/460 14/18639 0.142857142857143 5.78850931677019 0.0454660726318851 0.300745935863003 GO:0071933 Arp2/3 complex binding 2/460 14/18639 0.142857142857143 5.78850931677019 0.0454660726318851 0.300745935863003 GO:0042277 peptide binding 11/460 249/18639 0.0441767068273092 1.79002095337873 0.0455898484682302 0.300745935863003 GO:0071889 14-3-3 protein binding 3/460 33/18639 0.0909090909090909 3.68359683794466 0.0471743361223781 0.306258785302423 GO:0140311 protein sequestering activity 3/460 33/18639 0.0909090909090909 3.68359683794466 0.0471743361223781 0.306258785302423 GO:0015101 organic cation transmembrane transporter activity 5/460 81/18639 0.0617283950617284 2.5012077294686 0.0499254685705786 0.321567191265616 GO:0005523 tropomyosin binding 2/460 15/18639 0.133333333333333 5.40260869565217 0.0516228382550306 0.322347188493244 GO:0031386 protein tag activity 2/460 15/18639 0.133333333333333 5.40260869565217 0.0516228382550306 0.322347188493244 GO:0047372 monoacylglycerol lipase activity 2/460 15/18639 0.133333333333333 5.40260869565217 0.0516228382550306 0.322347188493244 GO:0141047 molecular tag activity 2/460 15/18639 0.133333333333333 5.40260869565217 0.0516228382550306 0.322347188493244 GO:0005154 epidermal growth factor receptor binding 3/460 35/18639 0.0857142857142857 3.47310559006211 0.054607926292792 0.33585927599627 GO:0140566 histone reader activity 3/460 35/18639 0.0857142857142857 3.47310559006211 0.054607926292792 0.33585927599627 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 18/460 484/18639 0.0371900826446281 1.50692597915918 0.0560859825717224 0.342375624952753 GO:0004708 MAP kinase kinase activity 2/460 16/18639 0.125 5.06494565217391 0.0580571513711745 0.351783332012005 GO:0001098 basal transcription machinery binding 4/460 60/18639 0.0666666666666667 2.70130434782609 0.0606053909466451 0.361862845214275 GO:0001099 basal RNA polymerase II transcription machinery binding 4/460 60/18639 0.0666666666666667 2.70130434782609 0.0606053909466451 0.361862845214275 GO:0001216 DNA-binding transcription activator activity 18/460 491/18639 0.0366598778004073 1.4854423093952 0.062565877383502 0.370861505070323 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/460 17/18639 0.117647058823529 4.76700767263427 0.0647516286808671 0.3730058609926 GO:0005092 GDP-dissociation inhibitor activity 2/460 17/18639 0.117647058823529 4.76700767263427 0.0647516286808671 0.3730058609926 GO:0036041 long-chain fatty acid binding 2/460 17/18639 0.117647058823529 4.76700767263427 0.0647516286808671 0.3730058609926 GO:0046965 nuclear retinoid X receptor binding 2/460 17/18639 0.117647058823529 4.76700767263427 0.0647516286808671 0.3730058609926 GO:0015179 L-amino acid transmembrane transporter activity 4/460 62/18639 0.0645161290322581 2.61416549789621 0.0667781660837744 0.381989789206486 GO:0003924 GTPase activity 13/460 331/18639 0.0392749244712991 1.59140286352292 0.0680059637611791 0.386311655254476 GO:1990782 protein tyrosine kinase binding 6/460 117/18639 0.0512820512820513 2.07792642140468 0.0699226339740671 0.394134237051717 GO:0000900 mRNA regulatory element binding translation repressor activity 2/460 18/18639 0.111111111111111 4.50217391304348 0.0716895725762105 0.394134237051717 GO:0017128 phospholipid scramblase activity 2/460 18/18639 0.111111111111111 4.50217391304348 0.0716895725762105 0.394134237051717 GO:0035615 clathrin adaptor activity 2/460 18/18639 0.111111111111111 4.50217391304348 0.0716895725762105 0.394134237051717 GO:0005516 calmodulin binding 9/460 207/18639 0.0434782608695652 1.7617202268431 0.0717921776536747 0.394134237051717 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/460 40/18639 0.075 3.03896739130435 0.0754372289199761 0.403317995140787 GO:0050997 quaternary ammonium group binding 3/460 40/18639 0.075 3.03896739130435 0.0754372289199761 0.403317995140787 GO:0061791 GTPase motor activity 3/460 40/18639 0.075 3.03896739130435 0.0754372289199761 0.403317995140787 GO:1990606 membrane scission GTPase motor activity 3/460 40/18639 0.075 3.03896739130435 0.0754372289199761 0.403317995140787 GO:0032182 ubiquitin-like protein binding 6/460 120/18639 0.05 2.02597826086957 0.0769365574377934 0.408663012883863 GO:0034987 immunoglobulin receptor binding 2/460 19/18639 0.105263157894737 4.26521739130435 0.0788549480045858 0.413482996588148 GO:0070003 threonine-type peptidase activity 2/460 19/18639 0.105263157894737 4.26521739130435 0.0788549480045858 0.413482996588148 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/460 41/18639 0.0731707317073171 2.96484623541888 0.0799680531175758 0.414011819304918 GO:0042287 MHC protein binding 3/460 41/18639 0.0731707317073171 2.96484623541888 0.0799680531175758 0.414011819304918 GO:0052745 inositol phosphate phosphatase activity 2/460 20/18639 0.1 4.05195652173913 0.0862323600527802 0.441640629951428 GO:0061135 endopeptidase regulator activity 8/460 184/18639 0.0434782608695652 1.7617202268431 0.0863844752961228 0.441640629951428 GO:0005548 phospholipid transporter activity 4/460 68/18639 0.0588235294117647 2.38350383631714 0.087151730007005 0.442795746246771 GO:0010314 phosphatidylinositol-5-phosphate binding 2/460 21/18639 0.0952380952380952 3.85900621118012 0.093807032230169 0.470054585573769 GO:0140312 cargo adaptor activity 2/460 21/18639 0.0952380952380952 3.85900621118012 0.093807032230169 0.470054585573769 GO:0001046 core promoter sequence-specific DNA binding 3/460 44/18639 0.0681818181818182 2.7626976284585 0.0942407726578217 0.470054585573769 GO:0140303 intramembrane lipid transporter activity 3/460 45/18639 0.0666666666666667 2.70130434782609 0.0992152806704523 0.490351948341658 GO:0061630 ubiquitin protein ligase activity 13/460 353/18639 0.0368271954674221 1.49222194851583 0.0995090750913388 0.490351948341658 GO:0140517 protein-RNA adaptor activity 2/460 22/18639 0.0909090909090909 3.68359683794466 0.101564785430215 0.497484996897698 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6/460 130/18639 0.0461538461538462 1.87013377926421 0.10306042886197 0.501806135768403 GO:0030276 clathrin binding 3/460 46/18639 0.0652173913043478 2.64258034026465 0.104293211951271 0.504803830628047 GO:0015171 amino acid transmembrane transporter activity 5/460 102/18639 0.0490196078431373 1.98625319693095 0.108073309710359 0.514738335379419 GO:0140359 ABC-type transporter activity 3/460 47/18639 0.0638297872340425 2.586355226642 0.109471473856547 0.514738335379419 GO:0043274 phospholipase binding 2/460 23/18639 0.0869565217391304 3.5234404536862 0.109492017550145 0.514738335379419 GO:0099186 structural constituent of postsynapse 2/460 23/18639 0.0869565217391304 3.5234404536862 0.109492017550145 0.514738335379419 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/460 23/18639 0.0869565217391304 3.5234404536862 0.109492017550145 0.514738335379419 GO:0003684 damaged DNA binding 4/460 74/18639 0.0540540540540541 2.19024676850764 0.110161316501389 0.514925467989352 GO:0032266 phosphatidylinositol-3-phosphate binding 3/460 48/18639 0.0625 2.53247282608696 0.114746939580936 0.531364139817047 GO:0000287 magnesium ion binding 9/460 230/18639 0.0391304347826087 1.58554820415879 0.117198357332029 0.531364139817047 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/460 24/18639 0.0833333333333333 3.37663043478261 0.117575683749249 0.531364139817047 GO:0004806 triacylglycerol lipase activity 2/460 24/18639 0.0833333333333333 3.37663043478261 0.117575683749249 0.531364139817047 GO:0030552 cAMP binding 2/460 24/18639 0.0833333333333333 3.37663043478261 0.117575683749249 0.531364139817047 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/460 24/18639 0.0833333333333333 3.37663043478261 0.117575683749249 0.531364139817047 GO:0045296 cadherin binding 12/460 334/18639 0.0359281437125748 1.45579276230148 0.125558733190077 0.553263875555397 GO:0003707 nuclear steroid receptor activity 2/460 25/18639 0.08 3.2415652173913 0.125803277326777 0.553263875555397 GO:0004709 MAP kinase kinase kinase activity 2/460 25/18639 0.08 3.2415652173913 0.125803277326777 0.553263875555397 GO:0008139 nuclear localization sequence binding 2/460 25/18639 0.08 3.2415652173913 0.125803277326777 0.553263875555397 GO:0042974 nuclear retinoic acid receptor binding 2/460 25/18639 0.08 3.2415652173913 0.125803277326777 0.553263875555397 GO:0005048 signal sequence binding 3/460 51/18639 0.0588235294117647 2.38350383631714 0.131124914581712 0.568627873380455 GO:0033293 monocarboxylic acid binding 4/460 79/18639 0.0506329113924051 2.05162355531095 0.131180556287974 0.568627873380455 GO:0061659 ubiquitin-like protein ligase activity 13/460 372/18639 0.0349462365591398 1.41600631136045 0.132836991583534 0.568627873380455 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/460 26/18639 0.0769230769230769 3.11688963210702 0.134162811201012 0.568627873380455 GO:0008198 ferrous iron binding 2/460 26/18639 0.0769230769230769 3.11688963210702 0.134162811201012 0.568627873380455 GO:0030507 spectrin binding 2/460 26/18639 0.0769230769230769 3.11688963210702 0.134162811201012 0.568627873380455 GO:0051139 metal cation:proton antiporter activity 2/460 26/18639 0.0769230769230769 3.11688963210702 0.134162811201012 0.568627873380455 GO:0030159 signaling receptor complex adaptor activity 3/460 52/18639 0.0576923076923077 2.33766722408027 0.136757466530309 0.576637152689655 GO:0004864 protein phosphatase inhibitor activity 3/460 53/18639 0.0566037735849057 2.29356029532404 0.142471293048908 0.586340755661989 GO:0008146 sulfotransferase activity 3/460 53/18639 0.0566037735849057 2.29356029532404 0.142471293048908 0.586340755661989 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/460 27/18639 0.0740740740740741 3.00144927536232 0.14264279997156 0.586340755661989 GO:0008320 protein transmembrane transporter activity 2/460 27/18639 0.0740740740740741 3.00144927536232 0.14264279997156 0.586340755661989 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/460 27/18639 0.0740740740740741 3.00144927536232 0.14264279997156 0.586340755661989 GO:0019955 cytokine binding 6/460 144/18639 0.0416666666666667 1.6883152173913 0.146350359394453 0.598572969923311 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/460 54/18639 0.0555555555555556 2.25108695652174 0.148263187781662 0.603379540325372 GO:0046966 nuclear thyroid hormone receptor binding 2/460 28/18639 0.0714285714285714 2.89425465838509 0.15123224254747 0.609398888688821 GO:0141052 histone H3 demethylase activity 2/460 28/18639 0.0714285714285714 2.89425465838509 0.15123224254747 0.609398888688821 GO:0015631 tubulin binding 13/460 385/18639 0.0337662337662338 1.36819311123659 0.158820032273691 0.632540760845346 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/460 29/18639 0.0689655172413793 2.79445277361319 0.159920605324271 0.632540760845346 GO:0051861 glycolipid binding 2/460 29/18639 0.0689655172413793 2.79445277361319 0.159920605324271 0.632540760845346 GO:0019212 phosphatase inhibitor activity 3/460 56/18639 0.0535714285714286 2.17069099378882 0.160068383245705 0.632540760845346 GO:0016504 peptidase activator activity 3/460 57/18639 0.0526315789473684 2.13260869565217 0.166075310562531 0.642212737070071 GO:0008081 phosphoric diester hydrolase activity 4/460 87/18639 0.0459770114942529 1.86296851574213 0.16787424579519 0.642212737070071 GO:0031624 ubiquitin conjugating enzyme binding 2/460 30/18639 0.0666666666666667 2.70130434782609 0.168697805893493 0.642212737070071 GO:0032452 histone demethylase activity 2/460 30/18639 0.0666666666666667 2.70130434782609 0.168697805893493 0.642212737070071 GO:0033612 receptor serine/threonine kinase binding 2/460 30/18639 0.0666666666666667 2.70130434782609 0.168697805893493 0.642212737070071 GO:0098918 structural constituent of synapse 2/460 30/18639 0.0666666666666667 2.70130434782609 0.168697805893493 0.642212737070071 GO:0000510 H3-H4 histone complex chaperone activity 6/460 151/18639 0.0397350993377483 1.61004894903542 0.170649699674045 0.642212737070071 GO:0140584 chromatin extrusion motor activity 6/460 151/18639 0.0397350993377483 1.61004894903542 0.170649699674045 0.642212737070071 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 6/460 151/18639 0.0397350993377483 1.61004894903542 0.170649699674045 0.642212737070071 GO:0140849 ATP-dependent H2AZ histone chaperone activity 6/460 151/18639 0.0397350993377483 1.61004894903542 0.170649699674045 0.642212737070071 GO:0015616 DNA translocase activity 6/460 152/18639 0.0394736842105263 1.59945652173913 0.174251607364298 0.642212737070071 GO:0140674 ATP-dependent histone chaperone activity 6/460 152/18639 0.0394736842105263 1.59945652173913 0.174251607364298 0.642212737070071 GO:0005164 tumor necrosis factor receptor binding 2/460 31/18639 0.0645161290322581 2.61416549789621 0.177554197268743 0.642212737070071 GO:0008327 methyl-CpG binding 2/460 31/18639 0.0645161290322581 2.61416549789621 0.177554197268743 0.642212737070071 GO:0016411 acylglycerol O-acyltransferase activity 2/460 31/18639 0.0645161290322581 2.61416549789621 0.177554197268743 0.642212737070071 GO:0140457 protein demethylase activity 2/460 31/18639 0.0645161290322581 2.61416549789621 0.177554197268743 0.642212737070071 GO:0003774 cytoskeletal motor activity 6/460 153/18639 0.0392156862745098 1.58900255754476 0.177884565331638 0.642212737070071 GO:0061775 cohesin loader activity 6/460 153/18639 0.0392156862745098 1.58900255754476 0.177884565331638 0.642212737070071 GO:0045309 protein phosphorylated amino acid binding 3/460 59/18639 0.0508474576271186 2.06031687546057 0.178282008627467 0.642212737070071 GO:0004540 RNA nuclease activity 5/460 121/18639 0.0413223140495868 1.67436219906576 0.179715628713899 0.642212737070071 GO:0004386 helicase activity 6/460 155/18639 0.0387096774193548 1.56849929873773 0.185241417615034 0.642212737070071 GO:0022884 macromolecule transmembrane transporter activity 2/460 32/18639 0.0625 2.53247282608696 0.186480552612831 0.642212737070071 GO:0043177 organic acid binding 7/460 189/18639 0.037037037037037 1.50072463768116 0.18736330709188 0.642212737070071 GO:0019001 guanyl nucleotide binding 13/460 400/18639 0.0325 1.31688586956522 0.191804719751239 0.642212737070071 GO:0032561 guanyl ribonucleotide binding 13/460 400/18639 0.0325 1.31688586956522 0.191804719751239 0.642212737070071 GO:0140658 ATP-dependent chromatin remodeler activity 6/460 158/18639 0.0379746835443038 1.53871766648321 0.196495543603335 0.642212737070071 GO:0061134 peptidase regulator activity 8/460 226/18639 0.0353982300884956 1.43432089265102 0.196808900981052 0.642212737070071 GO:0051213 dioxygenase activity 4/460 93/18639 0.043010752688172 1.74277699859748 0.197490261739519 0.642212737070071 GO:0051219 phosphoprotein binding 4/460 93/18639 0.043010752688172 1.74277699859748 0.197490261739519 0.642212737070071 GO:0046982 protein heterodimerization activity 12/460 369/18639 0.032520325203252 1.31770943796395 0.203178444095363 0.642212737070071 GO:0003689 DNA clamp loader activity 6/460 160/18639 0.0375 1.51948369565217 0.204137433819838 0.642212737070071 GO:0052866 phosphatidylinositol phosphate phosphatase activity 2/460 34/18639 0.0588235294117647 2.38350383631714 0.204508260355104 0.642212737070071 GO:0042826 histone deacetylase binding 5/460 127/18639 0.0393700787401575 1.59525847312564 0.205330940425095 0.642212737070071 GO:0005178 integrin binding 6/460 161/18639 0.0372670807453416 1.51004590872266 0.207998347333329 0.642212737070071 GO:0004896 cytokine receptor activity 4/460 96/18639 0.0416666666666667 1.6883152173913 0.212858348143617 0.642212737070071 GO:0000175 3'-5'-RNA exonuclease activity 2/460 35/18639 0.0571428571428571 2.31540372670807 0.213593129086153 0.642212737070071 GO:0043015 gamma-tubulin binding 2/460 35/18639 0.0571428571428571 2.31540372670807 0.213593129086153 0.642212737070071 GO:0038024 cargo receptor activity 3/460 65/18639 0.0461538461538462 1.87013377926421 0.216221776514013 0.642212737070071 GO:0120013 lipid transfer activity 3/460 65/18639 0.0461538461538462 1.87013377926421 0.216221776514013 0.642212737070071 GO:0016298 lipase activity 5/460 130/18639 0.0384615384615385 1.55844481605351 0.218570280484251 0.642212737070071 GO:0140713 histone chaperone activity 6/460 164/18639 0.0365853658536585 1.48242311770944 0.219733728788997 0.642212737070071 GO:0001094 TFIID-class transcription factor complex binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0003796 lysozyme activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0004382 GDP phosphatase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0005345 purine nucleobase transmembrane transporter activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0005381 iron ion transmembrane transporter activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0005522 profilin binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0008140 cAMP response element binding protein binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0032052 bile acid binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0043208 glycosphingolipid binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0045322 unmethylated CpG binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0050308 sugar-phosphatase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0050815 phosphoserine residue binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0070513 death domain binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0098505 G-rich strand telomeric DNA binding 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0140940 histone H2A methyltransferase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:1990259 histone H2AQ104 methyltransferase activity 1/460 10/18639 0.1 4.05195652173913 0.221161749665016 0.642212737070071 GO:0004842 ubiquitin-protein transferase activity 14/460 449/18639 0.0311804008908686 1.26341628740196 0.221747300675399 0.642212737070071 GO:0000993 RNA polymerase II complex binding 2/460 36/18639 0.0555555555555556 2.25108695652174 0.22271496717881 0.642212737070071 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/460 36/18639 0.0555555555555556 2.25108695652174 0.22271496717881 0.642212737070071 GO:0042626 ATPase-coupled transmembrane transporter activity 4/460 98/18639 0.0408163265306122 1.65385980479148 0.223283588086459 0.642212737070071 GO:0005525 GTP binding 12/460 378/18639 0.0317460317460317 1.28633540372671 0.226004747662033 0.642212737070071 GO:0023023 MHC protein complex binding 2/460 37/18639 0.0540540540540541 2.19024676850764 0.231866435957095 0.642212737070071 GO:0030551 cyclic nucleotide binding 2/460 37/18639 0.0540540540540541 2.19024676850764 0.231866435957095 0.642212737070071 GO:0043394 proteoglycan binding 2/460 37/18639 0.0540540540540541 2.19024676850764 0.231866435957095 0.642212737070071 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0000099 sulfur amino acid transmembrane transporter activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0001851 complement component C3b binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0008199 ferric iron binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0008432 JUN kinase binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0008526 phosphatidylinositol transfer activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0010854 adenylate cyclase regulator activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0015205 nucleobase transmembrane transporter activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0019203 carbohydrate phosphatase activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0032050 clathrin heavy chain binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0032794 GTPase activating protein binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0045294 alpha-catenin binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0050998 nitric-oxide synthase binding 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:0180030 inositol phosphate kinase activity 1/460 11/18639 0.0909090909090909 3.68359683794466 0.240393356039706 0.642212737070071 GO:1901681 sulfur compound binding 9/460 275/18639 0.0327272727272727 1.32609486166008 0.240469578942444 0.642212737070071 GO:0000146 microfilament motor activity 2/460 38/18639 0.0526315789473684 2.13260869565217 0.241040534966742 0.642212737070071 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/460 38/18639 0.0526315789473684 2.13260869565217 0.241040534966742 0.642212737070071 GO:0043531 ADP binding 2/460 38/18639 0.0526315789473684 2.13260869565217 0.241040534966742 0.642212737070071 GO:0008080 N-acetyltransferase activity 3/460 69/18639 0.0434782608695652 1.7617202268431 0.242375072882443 0.642212737070071 GO:0002020 protease binding 5/460 136/18639 0.0367647058823529 1.48968989769821 0.245789812532578 0.642212737070071 GO:0016782 transferase activity, transferring sulphur-containing groups 3/460 70/18639 0.0428571428571429 1.73655279503106 0.24899458454911 0.642212737070071 GO:0004722 protein serine/threonine phosphatase activity 4/460 103/18639 0.0388349514563107 1.57357534824821 0.249888804702363 0.642212737070071 GO:0000217 DNA secondary structure binding 2/460 39/18639 0.0512820512820513 2.07792642140468 0.250230589812118 0.642212737070071 GO:0004518 nuclease activity 7/460 209/18639 0.0334928229665072 1.35711462450593 0.258919092094387 0.642212737070071 GO:0000340 RNA 7-methylguanosine cap binding 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0004000 adenosine deaminase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0005078 MAP-kinase scaffold activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0005095 GTPase inhibitor activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0015132 prostaglandin transmembrane transporter activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0015166 polyol transmembrane transporter activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0016273 arginine N-methyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0016274 protein-arginine N-methyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0034452 dynactin binding 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0035497 cAMP response element binding 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0036009 protein-glutamine N-methyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0042301 phosphate ion binding 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0043047 single-stranded telomeric DNA binding 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/460 12/18639 0.0833333333333333 3.37663043478261 0.259151089356312 0.642212737070071 GO:0004532 RNA exonuclease activity 2/460 40/18639 0.05 2.02597826086957 0.259430240385389 0.642212737070071 GO:0015036 disulfide oxidoreductase activity 2/460 40/18639 0.05 2.02597826086957 0.259430240385389 0.642212737070071 GO:0032451 demethylase activity 2/460 40/18639 0.05 2.02597826086957 0.259430240385389 0.642212737070071 GO:0005518 collagen binding 3/460 72/18639 0.0416666666666667 1.6883152173913 0.262311908773823 0.642212737070071 GO:0008013 beta-catenin binding 4/460 106/18639 0.0377358490566038 1.52904019688269 0.266164540617398 0.642212737070071 GO:0001530 lipopolysaccharide binding 2/460 41/18639 0.0487804878048781 1.97656415694592 0.268633429476046 0.642212737070071 GO:0017080 sodium channel regulator activity 2/460 41/18639 0.0487804878048781 1.97656415694592 0.268633429476046 0.642212737070071 GO:0140318 protein transporter activity 2/460 41/18639 0.0487804878048781 1.97656415694592 0.268633429476046 0.642212737070071 GO:0140828 metal cation:monoatomic cation antiporter activity 2/460 41/18639 0.0487804878048781 1.97656415694592 0.268633429476046 0.642212737070071 GO:0004521 RNA endonuclease activity 3/460 73/18639 0.0410958904109589 1.66518761167362 0.269004444572889 0.642212737070071 GO:0019888 protein phosphatase regulator activity 4/460 107/18639 0.0373831775700935 1.51475010158472 0.271633158387613 0.642212737070071 GO:0043021 ribonucleoprotein complex binding 6/460 177/18639 0.0338983050847458 1.37354458364038 0.272867370358941 0.642212737070071 GO:0005319 lipid transporter activity 6/460 178/18639 0.0337078651685393 1.36582804103566 0.277083035154307 0.642212737070071 GO:0004465 lipoprotein lipase activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0004535 poly(A)-specific ribonuclease activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0008035 high-density lipoprotein particle binding 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0032396 inhibitory MHC class I receptor activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0071714 icosanoid transmembrane transporter activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0089720 caspase binding 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/460 13/18639 0.0769230769230769 3.11688963210702 0.277446601188389 0.642212737070071 GO:0008307 structural constituent of muscle 2/460 42/18639 0.0476190476190476 1.92950310559006 0.277834391749255 0.642212737070071 GO:0043175 RNA polymerase core enzyme binding 2/460 42/18639 0.0476190476190476 1.92950310559006 0.277834391749255 0.642212737070071 GO:0019003 GDP binding 3/460 75/18639 0.04 1.62078260869565 0.282444437583786 0.642212737070071 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/460 43/18639 0.0465116279069767 1.88463094034378 0.287027643081815 0.642212737070071 GO:0140034 methylation-dependent protein binding 3/460 76/18639 0.0394736842105263 1.59945652173913 0.289186914024637 0.642212737070071 GO:0004065 arylsulfatase activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0008474 palmitoyl-(protein) hydrolase activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0008559 ABC-type xenobiotic transporter activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0015386 potassium:proton antiporter activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0032036 myosin heavy chain binding 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0032454 histone H3K9 demethylase activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0042043 neurexin family protein binding 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0043176 amine binding 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0061783 peptidoglycan muralytic activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0098599 palmitoyl hydrolase activity 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0098847 sequence-specific single stranded DNA binding 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:1990825 sequence-specific mRNA binding 1/460 14/18639 0.0714285714285714 2.89425465838509 0.295291257231197 0.642212737070071 GO:0003724 RNA helicase activity 3/460 77/18639 0.038961038961039 1.57868435911914 0.295941141164422 0.642212737070071 GO:0001223 transcription coactivator binding 2/460 44/18639 0.0454545454545455 1.84179841897233 0.296207970244862 0.642212737070071 GO:0016790 thiolester hydrolase activity 2/460 44/18639 0.0454545454545455 1.84179841897233 0.296207970244862 0.642212737070071 GO:0043014 alpha-tubulin binding 2/460 44/18639 0.0454545454545455 1.84179841897233 0.296207970244862 0.642212737070071 GO:0019787 ubiquitin-like protein transferase activity 14/460 479/18639 0.0292275574112735 1.18428791867114 0.296560615395166 0.642212737070071 GO:0008186 ATP-dependent activity, acting on RNA 3/460 79/18639 0.0379746835443038 1.53871766648321 0.309475448354346 0.642212737070071 GO:0046332 SMAD binding 3/460 79/18639 0.0379746835443038 1.53871766648321 0.309475448354346 0.642212737070071 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0004953 icosanoid receptor activity 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0005041 low-density lipoprotein particle receptor activity 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0010181 FMN binding 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0015250 water channel activity 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0030553 cGMP binding 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0033130 acetylcholine receptor binding 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0048531 beta-1,3-galactosyltransferase activity 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0050700 CARD domain binding 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0050780 dopamine receptor binding 1/460 15/18639 0.0666666666666667 2.70130434782609 0.312696144300923 0.642212737070071 GO:0031406 carboxylic acid binding 6/460 187/18639 0.0320855614973262 1.30009300162753 0.315630523487521 0.642212737070071 GO:0046943 carboxylic acid transmembrane transporter activity 6/460 188/18639 0.0319148936170213 1.293177613321 0.319969393622942 0.642212737070071 GO:0140597 protein carrier chaperone 6/460 188/18639 0.0319148936170213 1.293177613321 0.319969393622942 0.642212737070071 GO:0001618 virus receptor activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0030971 receptor tyrosine kinase binding 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0033192 calmodulin-dependent protein phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0140791 histone H2AXS140 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/460 81/18639 0.037037037037037 1.50072463768116 0.323029080695481 0.642212737070071 GO:0001784 phosphotyrosine residue binding 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:0005504 fatty acid binding 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:0043495 protein-membrane adaptor activity 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:0061749 forked DNA-dependent helicase activity 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:0140938 histone H3 methyltransferase activity 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/460 47/18639 0.0425531914893617 1.72423681776133 0.323623130511198 0.642212737070071 GO:0005342 organic acid transmembrane transporter activity 6/460 189/18639 0.0317460317460317 1.28633540372671 0.324317134164944 0.642212737070071 GO:0019208 phosphatase regulator activity 4/460 117/18639 0.0341880341880342 1.38528428093645 0.327153160419013 0.642212737070071 GO:0005521 lamin binding 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0008296 3'-5'-DNA exonuclease activity 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0015385 sodium:proton antiporter activity 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0016722 oxidoreductase activity, acting on metal ions 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0022858 alanine transmembrane transporter activity 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0140328 floppase activity 1/460 16/18639 0.0625 2.53247282608696 0.329672077162906 0.642212737070071 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/460 82/18639 0.0365853658536585 1.48242311770944 0.329807660433006 0.642212737070071 GO:0033549 MAP kinase phosphatase activity 3/460 82/18639 0.0365853658536585 1.48242311770944 0.329807660433006 0.642212737070071 GO:0140272 exogenous protein binding 3/460 82/18639 0.0365853658536585 1.48242311770944 0.329807660433006 0.642212737070071 GO:0009378 four-way junction helicase activity 2/460 48/18639 0.0416666666666667 1.6883152173913 0.332704704029905 0.642212737070071 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/460 48/18639 0.0416666666666667 1.6883152173913 0.332704704029905 0.642212737070071 GO:0036121 double-stranded DNA helicase activity 2/460 48/18639 0.0416666666666667 1.6883152173913 0.332704704029905 0.642212737070071 GO:0038187 pattern recognition receptor activity 2/460 48/18639 0.0416666666666667 1.6883152173913 0.332704704029905 0.642212737070071 GO:0043138 3'-5' DNA helicase activity 2/460 48/18639 0.0416666666666667 1.6883152173913 0.332704704029905 0.642212737070071 GO:0001540 amyloid-beta binding 3/460 83/18639 0.036144578313253 1.46456259821896 0.336584596391429 0.642212737070071 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/460 83/18639 0.036144578313253 1.46456259821896 0.336584596391429 0.642212737070071 GO:0008135 translation factor activity, RNA binding 3/460 83/18639 0.036144578313253 1.46456259821896 0.336584596391429 0.642212737070071 GO:0016757 glycosyltransferase activity 8/460 267/18639 0.0299625468164794 1.21406936980948 0.339119744444433 0.642212737070071 GO:0001222 transcription corepressor binding 2/460 49/18639 0.0408163265306122 1.65385980479148 0.341751012510795 0.642212737070071 GO:0016755 aminoacyltransferase activity 14/460 496/18639 0.0282258064516129 1.14369740532959 0.341948466295807 0.642212737070071 GO:0017018 myosin phosphatase activity 3/460 84/18639 0.0357142857142857 1.44712732919255 0.34335783961691 0.642212737070071 GO:0051117 ATPase binding 3/460 84/18639 0.0357142857142857 1.44712732919255 0.34335783961691 0.642212737070071 GO:0180051 translation factor activity 3/460 84/18639 0.0357142857142857 1.44712732919255 0.34335783961691 0.642212737070071 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0004549 tRNA-specific ribonuclease activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0004550 nucleoside diphosphate kinase activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0008429 phosphatidylethanolamine binding 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0016018 cyclosporin A binding 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0016805 dipeptidase activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0017110 nucleoside diphosphate phosphatase activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0030548 acetylcholine receptor regulator activity 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0031489 myosin V binding 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0051787 misfolded protein binding 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0070492 oligosaccharide binding 1/460 17/18639 0.0588235294117647 2.38350383631714 0.346229605193034 0.642212737070071 GO:0003697 single-stranded DNA binding 4/460 121/18639 0.0330578512396694 1.3394897592526 0.349599211216927 0.645808360437638 GO:0016209 antioxidant activity 3/460 86/18639 0.0348837209302326 1.41347320525784 0.356885314265442 0.645808360437638 GO:0005125 cytokine activity 7/460 234/18639 0.0299145299145299 1.2121237458194 0.35688749890258 0.645808360437638 GO:0099106 ion channel regulator activity 5/460 160/18639 0.03125 1.26623641304348 0.360941435612802 0.645808360437638 GO:0000400 four-way junction DNA binding 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0003746 translation elongation factor activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0004706 JUN kinase kinase kinase activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0005372 water transmembrane transporter activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0008525 phosphatidylcholine transporter activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0030228 lipoprotein particle receptor activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0032393 MHC class I receptor activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0034185 apolipoprotein binding 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0050811 GABA receptor binding 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0098641 cadherin binding involved in cell-cell adhesion 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0099602 neurotransmitter receptor regulator activity 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:1901611 phosphatidylglycerol binding 1/460 18/18639 0.0555555555555556 2.25108695652174 0.362379018876376 0.645808360437638 GO:0004866 endopeptidase inhibitor activity 5/460 161/18639 0.031055900621118 1.25837159060221 0.365843457673042 0.647093370979647 GO:0005080 protein kinase C binding 2/460 52/18639 0.0384615384615385 1.55844481605351 0.368641513476162 0.647093370979647 GO:0004197 cysteine-type endopeptidase activity 3/460 88/18639 0.0340909090909091 1.38134881422925 0.370374739487607 0.647093370979647 GO:0008017 microtubule binding 8/460 276/18639 0.0289855072463768 1.17448015122873 0.372623884948922 0.647093370979647 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/460 53/18639 0.0377358490566038 1.52904019688269 0.377510933885074 0.647093370979647 GO:0140296 general transcription initiation factor binding 2/460 53/18639 0.0377358490566038 1.52904019688269 0.377510933885074 0.647093370979647 GO:0003756 protein disulfide isomerase activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0008301 DNA binding, bending 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0008574 plus-end-directed microtubule motor activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0022821 solute:potassium antiporter activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0030506 ankyrin binding 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0043395 heparan sulfate proteoglycan binding 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0046624 sphingolipid transporter activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0050145 nucleoside monophosphate kinase activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0140036 ubiquitin-modified protein reader activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:1990380 K48-linked deubiquitinase activity 1/460 19/18639 0.0526315789473684 2.13260869565217 0.378130356147031 0.647093370979647 GO:0001217 DNA-binding transcription repressor activity 8/460 278/18639 0.0287769784172662 1.16603065373788 0.380110022373631 0.647785511556959 GO:0004519 endonuclease activity 4/460 127/18639 0.031496062992126 1.27620677850051 0.383274984296465 0.647785511556959 GO:0003925 G protein activity 2/460 54/18639 0.037037037037037 1.50072463768116 0.386328154889051 0.647785511556959 GO:0017069 snRNA binding 2/460 54/18639 0.037037037037037 1.50072463768116 0.386328154889051 0.647785511556959 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 4/460 128/18639 0.03125 1.26623641304348 0.388873720000841 0.647785511556959 GO:0015399 primary active transmembrane transporter activity 5/460 166/18639 0.0301204819277108 1.22046883184914 0.390354810464367 0.647785511556959 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3/460 91/18639 0.032967032967033 1.33580984233158 0.39050600937983 0.647785511556959 GO:0000339 RNA cap binding 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0001614 purinergic nucleotide receptor activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0001972 retinoic acid binding 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0005326 neurotransmitter transmembrane transporter activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0010851 cyclase regulator activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0016004 phospholipase activator activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0016502 nucleotide receptor activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0016505 peptidase activator activity involved in apoptotic process 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0030742 GTP-dependent protein binding 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0061608 nuclear import signal receptor activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0140939 histone H4 methyltransferase activity 1/460 20/18639 0.05 2.02597826086957 0.393493408573044 0.647785511556959 GO:0035591 signaling adaptor activity 4/460 129/18639 0.0310077519379845 1.25642062689585 0.394465596036599 0.647785511556959 GO:0008374 O-acyltransferase activity 2/460 55/18639 0.0363636363636364 1.47343873517787 0.39509035134238 0.647785511556959 GO:0052689 carboxylic ester hydrolase activity 3/460 92/18639 0.0326086956521739 1.32129017013232 0.397182205353231 0.647785511556959 GO:0016247 channel regulator activity 5/460 168/18639 0.0297619047619048 1.20593944099379 0.400145819512315 0.647785511556959 GO:0030414 peptidase inhibitor activity 5/460 169/18639 0.029585798816568 1.19880370465655 0.405035489413219 0.647785511556959 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0001846 opsonin binding 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0005123 death receptor binding 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0019200 carbohydrate kinase activity 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0051010 microtubule plus-end binding 1/460 21/18639 0.0476190476190476 1.92950310559006 0.408477727390188 0.647785511556959 GO:0141108 transporter regulator activity 5/460 170/18639 0.0294117647058824 1.19175191815857 0.409920321869372 0.647785511556959 GO:0016410 N-acyltransferase activity 3/460 94/18639 0.0319148936170213 1.293177613321 0.410473667970808 0.647785511556959 GO:0004601 peroxidase activity 2/460 57/18639 0.0350877192982456 1.42173913043478 0.412439216247176 0.647785511556959 GO:0019207 kinase regulator activity 8/460 287/18639 0.0278745644599303 1.12946523254052 0.413864497293583 0.647785511556959 GO:0008094 ATP-dependent activity, acting on DNA 6/460 210/18639 0.0285714285714286 1.15770186335404 0.416609166007395 0.647785511556959 GO:0140104 molecular carrier activity 7/460 249/18639 0.0281124497991968 1.13910424305919 0.417417195254773 0.647785511556959 GO:0008408 3'-5' exonuclease activity 2/460 58/18639 0.0344827586206897 1.3972263868066 0.421021060863757 0.647785511556959 GO:0017116 single-stranded DNA helicase activity 2/460 58/18639 0.0344827586206897 1.3972263868066 0.421021060863757 0.647785511556959 GO:0008970 phospholipase A1 activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0032931 histone H3K56 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0033691 sialic acid binding 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0043992 histone H3K9 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0043993 histone H3K18 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0043994 histone H3K23 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0043999 histone H2AK5 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044012 histone H2AK9 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044014 histone H2BK5 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044015 histone H2BK12 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044016 histone H3K4 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044017 histone H3K27 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0044018 histone H3K36 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0046972 histone H4K16 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0050321 tau-protein kinase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0140035 ubiquitin-like protein reader activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0140908 histone H3K122 acetyltransferase activity 1/460 22/18639 0.0454545454545455 1.84179841897233 0.423092629388282 0.647785511556959 GO:0016407 acetyltransferase activity 3/460 96/18639 0.03125 1.26623641304348 0.423673898145444 0.647785511556959 GO:0015459 potassium channel regulator activity 2/460 59/18639 0.0338983050847458 1.37354458364038 0.429538220591346 0.653089710861935 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/460 59/18639 0.0338983050847458 1.37354458364038 0.429538220591346 0.653089710861935 GO:0070063 RNA polymerase binding 2/460 59/18639 0.0338983050847458 1.37354458364038 0.429538220591346 0.653089710861935 GO:0016779 nucleotidyltransferase activity 4/460 136/18639 0.0294117647058824 1.19175191815857 0.433332058231591 0.653785990573112 GO:0044325 transmembrane transporter binding 4/460 136/18639 0.0294117647058824 1.19175191815857 0.433332058231591 0.653785990573112 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0016493 C-C chemokine receptor activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0016849 phosphorus-oxygen lyase activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0042171 lysophosphatidic acid acyltransferase activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0044013 histone H2B acetyltransferase activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0071617 lysophospholipid acyltransferase activity 1/460 23/18639 0.0434782608695652 1.7617202268431 0.437347202653652 0.653785990573112 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/460 60/18639 0.0333333333333333 1.35065217391304 0.437988658721351 0.653785990573112 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/460 60/18639 0.0333333333333333 1.35065217391304 0.437988658721351 0.653785990573112 GO:0019887 protein kinase regulator activity 7/460 255/18639 0.0274509803921569 1.11230179028133 0.441569017722658 0.656802055793719 GO:0003713 transcription coactivator activity 7/460 256/18639 0.02734375 1.10795686141304 0.445580571594186 0.656802055793719 GO:0140097 catalytic activity, acting on DNA 9/460 336/18639 0.0267857142857143 1.08534549689441 0.44902483573871 0.656802055793719 GO:0070851 growth factor receptor binding 4/460 139/18639 0.0287769784172662 1.16603065373788 0.449788925428118 0.656802055793719 GO:0004622 lysophospholipase activity 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0015295 solute:proton symporter activity 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0019957 C-C chemokine binding 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0035035 histone acetyltransferase binding 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0043998 histone H2A acetyltransferase activity 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0048027 mRNA 5'-UTR binding 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0060229 lipase activator activity 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0070300 phosphatidic acid binding 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0070840 dynein complex binding 1/460 24/18639 0.0416666666666667 1.6883152173913 0.451250312171235 0.656802055793719 GO:0016887 ATP hydrolysis activity 11/460 417/18639 0.026378896882494 1.06886143259306 0.454184944130549 0.65895160333972 GO:0022804 active transmembrane transporter activity 12/460 457/18639 0.0262582056892779 1.06397107791837 0.454728399313263 0.65895160333972 GO:0016853 isomerase activity 5/460 180/18639 0.0277777777777778 1.12554347826087 0.458354421705091 0.65895160333972 GO:1901682 sulfur compound transmembrane transporter activity 2/460 63/18639 0.0317460317460317 1.28633540372671 0.462921334205156 0.65895160333972 GO:0001848 complement binding 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0015662 P-type ion transporter activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0017025 TBP-class protein binding 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0017056 structural constituent of nuclear pore 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0019707 protein-cysteine S-acyltransferase activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0047617 fatty acyl-CoA hydrolase activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0120020 cholesterol transfer activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0140358 P-type transmembrane transporter activity 1/460 25/18639 0.04 1.62078260869565 0.464810605289754 0.65895160333972 GO:0004536 DNA nuclease activity 2/460 64/18639 0.03125 1.26623641304348 0.471087224131565 0.66389451774126 GO:0019903 protein phosphatase binding 4/460 144/18639 0.0277777777777778 1.12554347826087 0.476863933561094 0.66389451774126 GO:0001637 G protein-coupled chemoattractant receptor activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0004529 DNA exonuclease activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0004950 chemokine receptor activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0008157 protein phosphatase 1 binding 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0016289 acyl-CoA hydrolase activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0043548 phosphatidylinositol 3-kinase binding 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0050681 nuclear androgen receptor binding 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0070006 metalloaminopeptidase activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0070412 R-SMAD binding 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0120014 phospholipid transfer activity 1/460 26/18639 0.0384615384615385 1.55844481605351 0.478036517053303 0.66389451774126 GO:0019843 rRNA binding 2/460 65/18639 0.0307692307692308 1.24675585284281 0.479178190722598 0.664352135612009 GO:0008194 UDP-glycosyltransferase activity 4/460 145/18639 0.0275862068965517 1.11778110944528 0.482218956429466 0.66743672818833 GO:0140098 catalytic activity, acting on RNA 10/460 387/18639 0.0258397932816537 1.04701718907988 0.486402962734621 0.672046940630973 GO:0008235 metalloexopeptidase activity 2/460 66/18639 0.0303030303030303 1.22786561264822 0.487192953293602 0.672046940630973 GO:0001671 ATPase activator activity 1/460 27/18639 0.037037037037037 1.50072463768116 0.490936275402601 0.673566679180321 GO:0023026 MHC class II protein complex binding 1/460 27/18639 0.037037037037037 1.50072463768116 0.490936275402601 0.673566679180321 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/460 27/18639 0.037037037037037 1.50072463768116 0.490936275402601 0.673566679180321 GO:0008234 cysteine-type peptidase activity 5/460 187/18639 0.0267379679144385 1.08341083468961 0.491588395440894 0.673566679180321 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 7/460 268/18639 0.0261194029850746 1.05834685269306 0.493229712054254 0.674685458963846 GO:0042054 histone methyltransferase activity 2/460 67/18639 0.0298507462686567 1.20953926022064 0.495130339642079 0.676154620746613 GO:0008514 organic anion transmembrane transporter activity 7/460 269/18639 0.0260223048327138 1.05441247777598 0.497149127806629 0.677779977576371 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/460 229/18639 0.0262008733624454 1.06164799696222 0.498905852156672 0.67854637118905 GO:0140223 general transcription initiation factor activity 2/460 68/18639 0.0294117647058824 1.19175191815857 0.502989281494259 0.67854637118905 GO:0036408 histone H3K14 acetyltransferase activity 1/460 28/18639 0.0357142857142857 1.44712732919255 0.503517906249088 0.67854637118905 GO:0046625 sphingolipid binding 1/460 28/18639 0.0357142857142857 1.44712732919255 0.503517906249088 0.67854637118905 GO:0046875 ephrin receptor binding 1/460 28/18639 0.0357142857142857 1.44712732919255 0.503517906249088 0.67854637118905 GO:0051393 alpha-actinin binding 1/460 28/18639 0.0357142857142857 1.44712732919255 0.503517906249088 0.67854637118905 GO:0051959 dynein light intermediate chain binding 1/460 28/18639 0.0357142857142857 1.44712732919255 0.503517906249088 0.67854637118905 GO:0019902 phosphatase binding 5/460 190/18639 0.0263157894736842 1.06630434782609 0.505606412663796 0.680240206511488 GO:0016279 protein-lysine N-methyltransferase activity 2/460 69/18639 0.0289855072463768 1.17448015122873 0.510768810109537 0.686057285171759 GO:0003785 actin monomer binding 1/460 29/18639 0.0344827586206897 1.3972263868066 0.515789238424974 0.686625520438556 GO:0010484 histone H3 acetyltransferase activity 1/460 29/18639 0.0344827586206897 1.3972263868066 0.515789238424974 0.686625520438556 GO:0016417 S-acyltransferase activity 1/460 29/18639 0.0344827586206897 1.3972263868066 0.515789238424974 0.686625520438556 GO:0043236 laminin binding 1/460 29/18639 0.0344827586206897 1.3972263868066 0.515789238424974 0.686625520438556 GO:0099604 ligand-gated calcium channel activity 1/460 29/18639 0.0344827586206897 1.3972263868066 0.515789238424974 0.686625520438556 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/460 70/18639 0.0285714285714286 1.15770186335404 0.518468052037785 0.686625520438556 GO:0016278 lysine N-methyltransferase activity 2/460 70/18639 0.0285714285714286 1.15770186335404 0.518468052037785 0.686625520438556 GO:0097110 scaffold protein binding 2/460 70/18639 0.0285714285714286 1.15770186335404 0.518468052037785 0.686625520438556 GO:1902936 phosphatidylinositol bisphosphate binding 3/460 111/18639 0.027027027027027 1.09512338425382 0.518746420086831 0.686625520438556 GO:0005126 cytokine receptor binding 7/460 275/18639 0.0254545454545455 1.03140711462451 0.520456616458308 0.687776271830204 GO:0001965 G-protein alpha-subunit binding 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0001968 fibronectin binding 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0031210 phosphatidylcholine binding 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0043995 histone H4K5 acetyltransferase activity 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0043996 histone H4K8 acetyltransferase activity 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0043997 histone H4K12 acetyltransferase activity 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0051721 protein phosphatase 2A binding 1/460 30/18639 0.0333333333333333 1.35065217391304 0.527757908512266 0.68852626660771 GO:0016758 hexosyltransferase activity 5/460 197/18639 0.0253807106598985 1.0284153608475 0.537693464636099 0.699294543617972 GO:0047499 calcium-independent phospholipase A2 activity 1/460 31/18639 0.032258064516129 1.30708274894811 0.539431365553717 0.699294543617972 GO:0070273 phosphatidylinositol-4-phosphate binding 1/460 31/18639 0.032258064516129 1.30708274894811 0.539431365553717 0.699294543617972 GO:0072349 modified amino acid transmembrane transporter activity 1/460 31/18639 0.032258064516129 1.30708274894811 0.539431365553717 0.699294543617972 GO:0003678 DNA helicase activity 2/460 74/18639 0.027027027027027 1.09512338425382 0.548447793720632 0.701819632835735 GO:0031491 nucleosome binding 2/460 74/18639 0.027027027027027 1.09512338425382 0.548447793720632 0.701819632835735 GO:0035064 methylated histone binding 2/460 74/18639 0.027027027027027 1.09512338425382 0.548447793720632 0.701819632835735 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0042910 xenobiotic transmembrane transporter activity 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0043425 bHLH transcription factor binding 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0047498 calcium-dependent phospholipase A2 activity 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0071813 lipoprotein particle binding 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0071814 protein-lipid complex binding 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0120015 sterol transfer activity 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0140142 nucleocytoplasmic carrier activity 1/460 32/18639 0.03125 1.26623641304348 0.550816875648584 0.701819632835735 GO:0019956 chemokine binding 1/460 33/18639 0.0303030303030303 1.22786561264822 0.561921526436011 0.714855067845501 GO:0098631 cell adhesion mediator activity 2/460 76/18639 0.0263157894736842 1.06630434782609 0.56293957427754 0.715038154905322 GO:0015291 secondary active transmembrane transporter activity 7/460 287/18639 0.024390243902439 0.988282078472959 0.565800958465433 0.717558424844533 GO:0008083 growth factor activity 4/460 162/18639 0.0246913580246914 1.00048309178744 0.569433691836702 0.718755873916968 GO:0008376 acetylgalactosaminyltransferase activity 1/460 34/18639 0.0294117647058824 1.19175191815857 0.572752231468766 0.718755873916968 GO:0015020 glucuronosyltransferase activity 1/460 34/18639 0.0294117647058824 1.19175191815857 0.572752231468766 0.718755873916968 GO:0015035 protein-disulfide reductase activity 1/460 34/18639 0.0294117647058824 1.19175191815857 0.572752231468766 0.718755873916968 GO:0016831 carboxy-lyase activity 1/460 34/18639 0.0294117647058824 1.19175191815857 0.572752231468766 0.718755873916968 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/460 34/18639 0.0294117647058824 1.19175191815857 0.572752231468766 0.718755873916968 GO:0033218 amide binding 6/460 247/18639 0.0242914979757085 0.984280936454849 0.572895879943598 0.718755873916968 GO:0004623 phospholipase A2 activity 1/460 35/18639 0.0285714285714286 1.15770186335404 0.583315734480019 0.727366266470512 GO:0010485 histone H4 acetyltransferase activity 1/460 35/18639 0.0285714285714286 1.15770186335404 0.583315734480019 0.727366266470512 GO:0016229 steroid dehydrogenase activity 1/460 35/18639 0.0285714285714286 1.15770186335404 0.583315734480019 0.727366266470512 GO:0061631 ubiquitin conjugating enzyme activity 1/460 35/18639 0.0285714285714286 1.15770186335404 0.583315734480019 0.727366266470512 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0005484 SNAP receptor activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0016409 palmitoyltransferase activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0045505 dynein intermediate chain binding 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0055106 ubiquitin-protein transferase regulator activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/460 36/18639 0.0277777777777778 1.12554347826087 0.593618613545768 0.730195527639756 GO:0042805 actinin binding 1/460 37/18639 0.027027027027027 1.09512338425382 0.603667285145453 0.741441200073545 GO:0005501 retinoid binding 1/460 38/18639 0.0263157894736842 1.06630434782609 0.613468008123256 0.748980344246005 GO:0019840 isoprenoid binding 1/460 38/18639 0.0263157894736842 1.06630434782609 0.613468008123256 0.748980344246005 GO:0042162 telomeric DNA binding 1/460 38/18639 0.0263157894736842 1.06630434782609 0.613468008123256 0.748980344246005 GO:0042887 amide transmembrane transporter activity 1/460 38/18639 0.0263157894736842 1.06630434782609 0.613468008123256 0.748980344246005 GO:0004527 exonuclease activity 2/460 84/18639 0.0238095238095238 0.964751552795031 0.617532434759068 0.752818974117611 GO:0140030 modification-dependent protein binding 4/460 173/18639 0.023121387283237 0.936868559939683 0.62129136284856 0.756136489640864 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/460 39/18639 0.0256410256410256 1.03896321070234 0.623026887552497 0.756136489640864 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/460 39/18639 0.0256410256410256 1.03896321070234 0.623026887552497 0.756136489640864 GO:0003823 antigen binding 4/460 174/18639 0.0229885057471264 0.931484257871064 0.625806512957455 0.757310359032723 GO:0016798 hydrolase activity, acting on glycosyl bonds 3/460 130/18639 0.0230769230769231 0.935066889632107 0.625845724579609 0.757310359032723 GO:0003735 structural constituent of ribosome 4/460 175/18639 0.0228571428571429 0.92616149068323 0.630287416727075 0.758448974512461 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/460 86/18639 0.0232558139534884 0.942315470171891 0.630335279434544 0.758448974512461 GO:0004177 aminopeptidase activity 1/460 40/18639 0.025 1.01298913043478 0.6323498785055 0.758448974512461 GO:0015144 carbohydrate transmembrane transporter activity 1/460 40/18639 0.025 1.01298913043478 0.6323498785055 0.758448974512461 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/460 40/18639 0.025 1.01298913043478 0.6323498785055 0.758448974512461 GO:0071949 FAD binding 1/460 40/18639 0.025 1.01298913043478 0.6323498785055 0.758448974512461 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/460 41/18639 0.024390243902439 0.988282078472959 0.641442789731236 0.765985696350585 GO:0042169 SH2 domain binding 1/460 41/18639 0.024390243902439 0.988282078472959 0.641442789731236 0.765985696350585 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/460 41/18639 0.024390243902439 0.988282078472959 0.641442789731236 0.765985696350585 GO:0016651 oxidoreductase activity, acting on NAD(P)H 2/460 88/18639 0.0227272727272727 0.920899209486166 0.642802094220795 0.766489960747246 GO:0004402 histone acetyltransferase activity 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0004520 DNA endonuclease activity 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0016859 cis-trans isomerase activity 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0031492 nucleosomal DNA binding 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0042056 chemoattractant activity 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0051879 Hsp90 protein binding 1/460 42/18639 0.0238095238095238 0.964751552795031 0.650311287242991 0.768610394148612 GO:0015297 antiporter activity 3/460 135/18639 0.0222222222222222 0.900434782608696 0.65115770555622 0.768610394148612 GO:0008200 ion channel inhibitor activity 1/460 43/18639 0.0232558139534884 0.942315470171891 0.658960897818258 0.773357266019132 GO:0008375 acetylglucosaminyltransferase activity 1/460 43/18639 0.0232558139534884 0.942315470171891 0.658960897818258 0.773357266019132 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/460 43/18639 0.0232558139534884 0.942315470171891 0.658960897818258 0.773357266019132 GO:0048156 tau protein binding 1/460 43/18639 0.0232558139534884 0.942315470171891 0.658960897818258 0.773357266019132 GO:0003954 NADH dehydrogenase activity 1/460 44/18639 0.0227272727272727 0.920899209486166 0.667397012412988 0.778788525183772 GO:0016248 channel inhibitor activity 1/460 44/18639 0.0227272727272727 0.920899209486166 0.667397012412988 0.778788525183772 GO:0019205 nucleobase-containing compound kinase activity 1/460 44/18639 0.0227272727272727 0.920899209486166 0.667397012412988 0.778788525183772 GO:0030547 signaling receptor inhibitor activity 1/460 44/18639 0.0227272727272727 0.920899209486166 0.667397012412988 0.778788525183772 GO:0008237 metallopeptidase activity 4/460 184/18639 0.0217391304347826 0.88086011342155 0.669047110147872 0.779493878144867 GO:0140101 catalytic activity, acting on a tRNA 3/460 139/18639 0.0215827338129496 0.87452299030341 0.67051207701449 0.779493878144867 GO:0004175 endopeptidase activity 9/460 405/18639 0.0222222222222222 0.900434782608696 0.671918361308142 0.779493878144867 GO:0015078 proton transmembrane transporter activity 4/460 185/18639 0.0216216216216216 0.876098707403055 0.673177130704598 0.779493878144867 GO:0008009 chemokine activity 1/460 45/18639 0.0222222222222222 0.900434782608696 0.675624889492311 0.779493878144867 GO:0046915 transition metal ion transmembrane transporter activity 1/460 45/18639 0.0222222222222222 0.900434782608696 0.675624889492311 0.779493878144867 GO:0051539 4 iron, 4 sulfur cluster binding 1/460 45/18639 0.0222222222222222 0.900434782608696 0.675624889492311 0.779493878144867 GO:0141110 transporter inhibitor activity 1/460 45/18639 0.0222222222222222 0.900434782608696 0.675624889492311 0.779493878144867 GO:0042562 hormone binding 2/460 94/18639 0.0212765957446809 0.862118408880666 0.678211810714516 0.781376424175316 GO:0004180 carboxypeptidase activity 1/460 46/18639 0.0217391304347826 0.88086011342155 0.683649658279745 0.78343253604188 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/460 46/18639 0.0217391304347826 0.88086011342155 0.683649658279745 0.78343253604188 GO:0030291 protein serine/threonine kinase inhibitor activity 1/460 46/18639 0.0217391304347826 0.88086011342155 0.683649658279745 0.78343253604188 GO:0008276 protein methyltransferase activity 2/460 95/18639 0.0210526315789474 0.85304347826087 0.683827421435089 0.78343253604188 GO:0061733 protein-lysine-acetyltransferase activity 1/460 47/18639 0.0212765957446809 0.862118408880666 0.691476321926887 0.791087596274397 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/460 48/18639 0.0208333333333333 0.844157608695652 0.699109760605547 0.798703609183432 GO:0008170 N-methyltransferase activity 2/460 98/18639 0.0204081632653061 0.826929902395741 0.700193859555494 0.798826467386881 GO:0015293 symporter activity 3/460 146/18639 0.0205479452054795 0.832593805836808 0.702465660244369 0.80030210317534 GO:0060590 ATPase regulator activity 1/460 49/18639 0.0204081632653061 0.826929902395741 0.706554734524187 0.803841130515696 GO:0008236 serine-type peptidase activity 4/460 194/18639 0.0206185567010309 0.835454952935903 0.708738009018829 0.805205126913058 GO:0005539 glycosaminoglycan binding 5/460 242/18639 0.0206611570247934 0.837181099532878 0.716298452576807 0.812272194845425 GO:0019842 vitamin binding 3/460 150/18639 0.02 0.810391304347826 0.719638096180778 0.812272194845425 GO:0003743 translation initiation factor activity 1/460 51/18639 0.0196078431372549 0.794501278772378 0.720897746682242 0.812272194845425 GO:0016597 amino acid binding 1/460 51/18639 0.0196078431372549 0.794501278772378 0.720897746682242 0.812272194845425 GO:0016830 carbon-carbon lyase activity 1/460 51/18639 0.0196078431372549 0.794501278772378 0.720897746682242 0.812272194845425 GO:0008238 exopeptidase activity 2/460 102/18639 0.0196078431372549 0.794501278772378 0.720916397870145 0.812272194845425 GO:0017171 serine hydrolase activity 4/460 198/18639 0.0202020202020202 0.818577075098814 0.723611890184525 0.81418779390776 GO:0016829 lyase activity 4/460 200/18639 0.02 0.810391304347826 0.730834826808695 0.817489335214781 GO:0042393 histone binding 5/460 247/18639 0.0202429149797571 0.820234113712375 0.732760538062382 0.817489335214781 GO:0005246 calcium channel regulator activity 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0005544 calcium-dependent phospholipid binding 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0016860 intramolecular oxidoreductase activity 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0017046 peptide hormone binding 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0034212 protein N-acetyltransferase activity 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0051018 protein kinase A binding 1/460 53/18639 0.0188679245283019 0.764520098441345 0.734541150834797 0.817489335214781 GO:0000149 SNARE binding 2/460 106/18639 0.0188679245283019 0.764520098441345 0.740419574780345 0.821448465612707 GO:0015485 cholesterol binding 1/460 54/18639 0.0185185185185185 0.75036231884058 0.741111207362076 0.821448465612707 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/460 54/18639 0.0185185185185185 0.75036231884058 0.741111207362076 0.821448465612707 GO:0001664 G protein-coupled receptor binding 6/460 297/18639 0.0202020202020202 0.818577075098814 0.744936989905158 0.824571661356453 GO:0098632 cell-cell adhesion mediator activity 1/460 55/18639 0.0181818181818182 0.736719367588933 0.74751900099207 0.826311544339883 GO:0004843 cysteine-type deubiquitinase activity 2/460 108/18639 0.0185185185185185 0.75036231884058 0.749727510107764 0.826519007099934 GO:0005496 steroid binding 2/460 108/18639 0.0185185185185185 0.75036231884058 0.749727510107764 0.826519007099934 GO:0170055 lipid transmembrane transporter activity 1/460 56/18639 0.0178571428571429 0.723563664596273 0.753768530670484 0.829294842643845 GO:0004620 phospholipase activity 2/460 109/18639 0.018348623853211 0.743478260869565 0.754273059812984 0.829294842643845 GO:0004222 metalloendopeptidase activity 2/460 110/18639 0.0181818181818182 0.736719367588933 0.758747306777729 0.833094358314339 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1/460 58/18639 0.0172413793103448 0.698613193403298 0.765808304650975 0.839720098129354 GO:0043022 ribosome binding 2/460 112/18639 0.0178571428571429 0.723563664596273 0.767484866445733 0.84043188855771 GO:0001786 phosphatidylserine binding 1/460 59/18639 0.0169491525423729 0.686772291820192 0.771606064720969 0.841565014589004 GO:0031593 polyubiquitin modification-dependent protein binding 1/460 59/18639 0.0169491525423729 0.686772291820192 0.771606064720969 0.841565014589004 GO:0036002 pre-mRNA binding 1/460 59/18639 0.0169491525423729 0.686772291820192 0.771606064720969 0.841565014589004 GO:0101005 deubiquitinase activity 2/460 115/18639 0.0173913043478261 0.70468809073724 0.780075186908632 0.849669111706074 GO:0019905 syntaxin binding 1/460 61/18639 0.0163934426229508 0.664255167498218 0.782775432343773 0.851476467629263 GO:0009055 electron transfer activity 2/460 116/18639 0.0172413793103448 0.698613193403298 0.784137408495471 0.851825232601986 GO:0022853 active monoatomic ion transmembrane transporter activity 2/460 118/18639 0.0169491525423729 0.686772291820192 0.792064649283411 0.859295600946725 GO:0008201 heparin binding 3/460 172/18639 0.0174418604651163 0.706736602628918 0.800571279935963 0.867373916539891 GO:0160215 deacylase activity 1/460 65/18639 0.0153846153846154 0.623377926421405 0.803505423824635 0.869401371281153 GO:0008528 G protein-coupled peptide receptor activity 2/460 122/18639 0.0163934426229508 0.664255167498218 0.807152067779405 0.872193383677085 GO:0004252 serine-type endopeptidase activity 3/460 176/18639 0.0170454545454545 0.690674407114624 0.812974483402244 0.875171582591031 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/460 67/18639 0.0149253731343284 0.604769630110318 0.813117851796068 0.875171582591031 GO:0050840 extracellular matrix binding 1/460 67/18639 0.0149253731343284 0.604769630110318 0.813117851796068 0.875171582591031 GO:0003777 microtubule motor activity 1/460 68/18639 0.0147058823529412 0.595875959079284 0.817746636427438 0.87554548245765 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/460 68/18639 0.0147058823529412 0.595875959079284 0.817746636427438 0.87554548245765 GO:0030145 manganese ion binding 1/460 68/18639 0.0147058823529412 0.595875959079284 0.817746636427438 0.87554548245765 GO:0032934 sterol binding 1/460 68/18639 0.0147058823529412 0.595875959079284 0.817746636427438 0.87554548245765 GO:0002039 p53 binding 1/460 69/18639 0.0144927536231884 0.587240075614367 0.822261016226231 0.879228119311185 GO:0019783 ubiquitin-like protein peptidase activity 2/460 127/18639 0.015748031496063 0.638103389250257 0.82463733262734 0.88061793484225 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3/460 181/18639 0.0165745856353591 0.671595003603171 0.827555535431014 0.881862529985731 GO:0001653 peptide receptor activity 2/460 128/18639 0.015625 0.633118206521739 0.827958952358241 0.881862529985731 GO:0042379 chemokine receptor binding 1/460 72/18639 0.0138888888888889 0.562771739130435 0.835145597282077 0.888360336250636 GO:0031072 heat shock protein binding 2/460 131/18639 0.0152671755725191 0.61861931629605 0.837586817678992 0.889800021897942 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/460 73/18639 0.0136986301369863 0.555062537224538 0.839229887972563 0.89038916778412 GO:0005179 hormone activity 2/460 132/18639 0.0151515151515152 0.613932806324111 0.840686319672022 0.890779027839008 GO:0048029 monosaccharide binding 1/460 74/18639 0.0135135135135135 0.54756169212691 0.843213204332178 0.892300648310119 GO:0051536 iron-sulfur cluster binding 1/460 76/18639 0.0131578947368421 0.533152173913043 0.850886816913926 0.899257643715235 GO:0051540 metal cluster binding 1/460 77/18639 0.012987012987013 0.526228119706381 0.854581912761558 0.901997425340586 GO:0004713 protein tyrosine kinase activity 2/460 140/18639 0.0142857142857143 0.578850931677019 0.863614255506118 0.910356264180418 GO:0000049 tRNA binding 1/460 80/18639 0.0125 0.506494565217391 0.865127930735762 0.910778181907147 GO:0005254 chloride channel activity 1/460 83/18639 0.0120481927710843 0.488187532739654 0.874910671520538 0.918712361108858 GO:0030165 PDZ domain binding 1/460 83/18639 0.0120481927710843 0.488187532739654 0.874910671520538 0.918712361108858 GO:0015085 calcium ion transmembrane transporter activity 2/460 147/18639 0.0136054421768707 0.551286601597161 0.881155525883736 0.924083615606277 GO:0050660 flavin adenine dinucleotide binding 1/460 86/18639 0.0116279069767442 0.471157735085945 0.883985266349059 0.925864209825263 GO:0003727 single-stranded RNA binding 1/460 89/18639 0.0112359550561798 0.455276013678554 0.892402872410072 0.93348535758496 GO:0005506 iron ion binding 2/460 154/18639 0.012987012987013 0.526228119706381 0.896593419760986 0.936602906307796 GO:0072341 modified amino acid binding 1/460 91/18639 0.010989010989011 0.445269947443861 0.897673201155639 0.936602906307796 GO:0043178 alcohol binding 1/460 92/18639 0.0108695652173913 0.440430056710775 0.900210958728876 0.938054221962064 GO:0030246 carbohydrate binding 4/460 280/18639 0.0142857142857143 0.578850931677019 0.917680228269866 0.955041255375001 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/460 167/18639 0.0119760479041916 0.485264254100495 0.920427280237332 0.956682992673618 GO:0005253 monoatomic anion channel activity 1/460 103/18639 0.00970873786407767 0.393393837062051 0.924304229079354 0.95949347637933 GO:0035401 histone H3Y41 kinase activity 1/460 115/18639 0.00869565217391304 0.35234404536862 0.944015475960043 0.977474252323184 GO:0140801 histone H2AXY142 kinase activity 1/460 115/18639 0.00869565217391304 0.35234404536862 0.944015475960043 0.977474252323184 GO:0015294 solute:monoatomic cation symporter activity 1/460 116/18639 0.00862068965517241 0.349306596701649 0.945405720024952 0.977676206043503 GO:0015108 chloride transmembrane transporter activity 1/460 121/18639 0.00826446280991736 0.334872439813151 0.951856911633355 0.983098620803089 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/460 122/18639 0.00819672131147541 0.332127583749109 0.953052819433801 0.983098620803089 GO:0003730 mRNA 3'-UTR binding 3/460 262/18639 0.0114503816793893 0.463964487222038 0.958655296971712 0.987632283278162 GO:0005262 calcium channel activity 1/460 131/18639 0.00763358778625954 0.309309658148025 0.962566301092954 0.988750446218876 GO:0008168 methyltransferase activity 2/460 204/18639 0.00980392156862745 0.397250639386189 0.963053108055234 0.988750446218876 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/460 132/18639 0.00757575757575758 0.306966403162055 0.963496682630518 0.988750446218876 GO:0051087 protein-folding chaperone binding 1/460 134/18639 0.00746268656716418 0.302384815055159 0.965288792409454 0.988750446218876 GO:0019838 growth factor binding 1/460 136/18639 0.00735294117647059 0.297937979539642 0.966993101436554 0.988750446218876 GO:0099094 ligand-gated monoatomic cation channel activity 1/460 136/18639 0.00735294117647059 0.297937979539642 0.966993101436554 0.988750446218876 GO:0016741 transferase activity, transferring one-carbon groups 2/460 215/18639 0.00930232558139535 0.376926188068756 0.970739993605422 0.991005076436213 GO:0020037 heme binding 1/460 142/18639 0.00704225352112676 0.285349050826699 0.971621114060932 0.991005076436213 GO:0008509 monoatomic anion transmembrane transporter activity 1/460 149/18639 0.00671140939597315 0.271943390720747 0.976208390341612 0.994443914445129 GO:0046906 tetrapyrrole binding 1/460 152/18639 0.00657894736842105 0.266576086956522 0.977940357260585 0.99496916945169 GO:0015079 potassium ion transmembrane transporter activity 1/460 160/18639 0.00625 0.253247282608696 0.981968252155035 0.996222879690575 GO:0015081 sodium ion transmembrane transporter activity 1/460 164/18639 0.00609756097560976 0.24707051961824 0.983697916827735 0.996222879690575 GO:0015103 inorganic anion transmembrane transporter activity 1/460 165/18639 0.00606060606060606 0.245573122529644 0.984103814433107 0.996222879690575 GO:0016874 ligase activity 1/460 167/18639 0.00598802395209581 0.242632127050247 0.98488560521037 0.996222879690575 GO:0005201 extracellular matrix structural constituent 1/460 168/18639 0.00595238095238095 0.241187888198758 0.985261992261216 0.996222879690575 GO:0022832 voltage-gated channel activity 1/460 175/18639 0.00571428571428571 0.231540372670807 0.987647408142869 0.997401950445515 GO:0015276 ligand-gated monoatomic ion channel activity 1/460 186/18639 0.00537634408602151 0.217847124824684 0.990641626652254 0.998425815012218 GO:0022834 ligand-gated channel activity 1/460 188/18639 0.00531914893617021 0.215529602220167 0.991102398276187 0.998425815012218 GO:0045182 translation regulator activity 3/460 356/18639 0.00842696629213483 0.341457010258915 0.993450022012997 0.999044297852697 GO:0046873 metal ion transmembrane transporter activity 4/460 450/18639 0.00888888888888889 0.360173913043478 0.996108672401117 0.999044297852697 GO:0022836 gated channel activity 2/460 318/18639 0.00628930817610063 0.254840032813782 0.996965454854452 0.999044297852697 GO:0030371 translation repressor activity 2/460 329/18639 0.0060790273556231 0.246319545394476 0.99763403869666 0.999044297852697 GO:0005261 monoatomic cation channel activity 2/460 341/18639 0.00586510263929619 0.237651408899656 0.998198762425777 0.999044297852697 GO:0005216 monoatomic ion channel activity 3/460 448/18639 0.00669642857142857 0.271336374223602 0.999044297852697 0.999044297852697